CN104398841A

CN104398841A - Traditional Chinese medicine preparation for treating cataract and glaucoma and preparation method of traditional Chinese medicine preparation

Info

Publication number: CN104398841A
Application number: CN201410666517.4A
Authority: CN
Inventors: 王涛; 曹静
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-11-20
Filing date: 2014-11-20
Publication date: 2015-03-11

Abstract

The invention discloses a traditional Chinese medicine preparation for treating cataract and glaucoma and a preparation method of the traditional Chinese medicine preparation and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine preparation comprises the following principal raw materials: rhizoma alismatis, cassia seeds, Chinese yam, fructus lycii, caltrop, cuscuta chinensis, gardenia florida, radix scutellariae, rhizoma cimicifugae, rhubarb, chamomile, dendrobium nobile, poria cocos, radix paeoniae rubra, radix ophiopogonis, amoorcorn tree bark, mulberry bark and liquorice. The traditional Chinese medicine preparation prepared by the preparation method from the raw materials have a very significant curative effect on eye diseases such as the cataract and the glaucoma; a preparation technology of the traditional Chinese medicine preparation is simple and convenient; and the traditional Chinese medicine preparation has stable medicine efficacy, is small in individual variation and easy to popularize and apply and benefits more patients.

Description

A kind of Chinese medicine preparation for the treatment of cataract and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of cataract and preparation method thereof, belong to technical field of Chinese medicines.

Technical background

Cataract refers to that intraocular crystalline lens muddiness occurs, becomes opaque by transparent, hinders light to enter ophthalmic, thus affects one's power of vision.Not affecting one's power of vision when early stage muddiness is slight or scope is less, then increasing the weight of to obviously affecting one's power of vision even blind gradually.Cataractous cardinal symptom is visual deterioration, occurs blurred vision, at the moment stationarity shadow, diplopia etc. clinically during the initial stage.Even only light sensation is had when visual deterioration is obvious.Senile cataract, from just playing full maturity, the time is different in size, at least the several months, and elder can reach the several years, even many decades, also likely stops to some stages, static constant.

Glaucoma refers to that intraocular pressure is interrupted or continues a kind of oculopathy of raising, and lasting Bulbi hypertonia bring infringement can to eyeball each several part tissue and visual function, and as treated not in time, the visual field can total loss and arrive blind.

Current western medical treatment cataract, mainly through the treatment means such as laser, operation.

Without the name of cataract in Chinese medical book.The so-called cataract one of the present is sick, is included among this large class of cataracta ophthalmopathy, as cataract, cataract etc.Primary disease is called " mature cataract " by the Tang Dynasty " medical secrets of official ", meaning: " without institute because rising, suddenly misty, superficial ... in small bead, be have it to hinder, make Bluish white, though do not distinguish thing, still know light and shade three light." symptom describe rather careful.Because the degree of each one eyeball pearl muddiness, color, form, position and reason are different, title is respectively different to some extent.The period of the Song and Yuan Dynasties " secretly handing down ophthalmology dragon originally a to swing " book, 23 kinds more than are had to cataracta ophthalmopathy classification, often kind of disease, has all done concrete discussion, and the medical book such as Effective Formulas Tested by Physicians for Generations, " Precious Book of Ophthalmology ", " Standards of Diagnosis and Treatment ", " order is through great achievement " of later age also more touches upon.In pathogenesis, " Medulla Junci opinion " thinks that Yuan Dynasty's Ni Weide is then emphasized primarily of caused by liver-wind or pyretic accumulation of liver " cloudy weak can not join sun ", and deficiency of kidney yin is it.Ming Dynasty's " Compendium of Acupuncture and Moxibustion " thinks that its cause of disease is for " anger impairing the liver, blood is not just given up, exhaustion of kidney-YIN, and QI and blood dissipates ".

Glaucoma belongs to it " tendencies " cataract of Chinese medicine, comprises bluish glaucoma, glaucoma, absolute glaucoma with cataract III glaucoma and black glaucoma, common with the former two.In " medical secrets of official " of the Tang Dynasty Wang Tao, namely there is describing of acute congestive glaucoma, and think to be " ophthalmic common hepatic duct lacks, caused by eyelet is obstructed also ".To Song dynasty Holy Benevolent Prescriptions, specifically describe treatment side's medicine of green grass or young crops, green, black, black glaucoma.About become book in the famous ophthalmography " Long Mu's Secret Treatise on Ophthalmology " of China of the period of the Song and Yuan Dynasties, propose the name that tendencies becomes cataract first, and all discussed with regard to etiology and pathogenesis, clinical disease, the side's for the treatment of medicine (comprising acupuncture) respectively, particularly liver-wind is this theory, on creating important impact later age.To the period of Ming and Qing, doctors are to the darker people of the understanding of primary disease.Ming Dynasty's Fu Renyu points out the primary disease cause of disease in " Precious Book of Ophthalmology ": " people of deficiency of YIN insufficiency of blood, and exhaust think of of working with one's mind, melancholy angryly to anger, too person diligently, often have this disease.”。

Summary of the invention

The technical problem to be solved in the present invention is a kind of Chinese medicine of exploitation, this treatment by Chinese herbs cataract has significant effect, and this Chinese medicine is after utilizing modern pharmaceutical technology to be processed into finished product preparation, and it is stable curative effect not only, and general applicability is strong, individual variation is little.

In order to solve the problems of the technologies described above, inventor sums up the Couple herbs of ancestor, according to the traditional Chinese medical science to the dialectical cognition of the ophthalmics such as cataract, in conjunction with the practice of taking up a job as a doctor of self, through repeatedly groping and adjusting, finally invented a Chinese prescription and preparation technology supporting with it, this Chinese prescription does not singly completely solve above-mentioned technical problem, and its preparation technology is easy, efficacy stability, be easy to apply.This Chinese prescription is (with parts by weight):

Rhizoma Alismatis 18-32 part, Semen Cassiae 21-35 part, Rhizoma Dioscoreae 11-23 part, Fructus Lycii 10-22 part, Fructus Tribuli 8-16 part, Semen Cuscutae 11-23 part, gardenia florida 8-16 part, Radix Scutellariae 11-25 part, Rhizoma Cimicifugae 12-28 part, Radix Et Rhizoma Rhei 9-19 part, Flos Chrysanthemi 7-17 part, Dendrobium nobile 10-22 part, Poria 7-17 part, Radix Paeoniae Rubra 8-18 part, Radix Ophiopogonis 10-22 part, Cortex Phellodendri 7-13 part, Cortex Mori 9-19 part, Radix Glycyrrhizae 9-15 part.

Preferably, the Chinese prescription of above-mentioned treatment cataract is (with parts by weight):

Rhizoma Alismatis 20-30 part, Semen Cassiae 25-30 part, Rhizoma Dioscoreae 12-20 part, Fructus Lycii 12-20 part, Fructus Tribuli 10-14 part, Semen Cuscutae 12-20 part, gardenia florida 9-15 part, Radix Scutellariae 13-23 part, Rhizoma Cimicifugae 15-26 part, Radix Et Rhizoma Rhei 9-17 part, Flos Chrysanthemi 8-14 part, Dendrobium nobile 12-21 part, Poria 9-14 part, Radix Paeoniae Rubra 10-17 part, Radix Ophiopogonis 11-21 part, Cortex Phellodendri 7-10 part, Cortex Mori 11-14 part, Radix Glycyrrhizae 10-15 part.

By above-mentioned prescription, two proportionings optimized further are in practice (with parts by weight):

1, Rhizoma Alismatis 25 parts, Semen Cassiae 28 parts, Rhizoma Dioscoreae 17 parts, Fructus Lycii 16 parts, Fructus Tribuli 12 parts, Semen Cuscutae 17 parts, gardenia florida 12 parts, Radix Scutellariae 18 parts, Rhizoma Cimicifugae 20 parts, Radix Et Rhizoma Rhei 14 parts, Flos Chrysanthemi 12 parts, Dendrobium nobile 16 parts, 12 parts, Poria, Radix Paeoniae Rubra 13 parts, Radix Ophiopogonis 16 parts, Cortex Phellodendri 10 parts, Cortex Mori 14 parts, 12 parts, Radix Glycyrrhizae.

2, Rhizoma Alismatis 27 parts, Semen Cassiae 30 parts, Rhizoma Dioscoreae 16 parts, Fructus Lycii 18 parts, Fructus Tribuli 10 parts, Semen Cuscutae 16 parts, gardenia florida 11 parts, Radix Scutellariae 17 parts, Rhizoma Cimicifugae 18 parts, Radix Et Rhizoma Rhei 15 parts, Flos Chrysanthemi 13 parts, Dendrobium nobile 17 parts, 13 parts, Poria, Radix Paeoniae Rubra 12 parts, Radix Ophiopogonis 15 parts, Cortex Phellodendri 9 parts, Cortex Mori 12 parts, 13 parts, Radix Glycyrrhizae.

Above-mentioned Chinese prescription is made and facilitates the preparation method of easy-to-use finished product preparation to be following steps:

Step 1, accurately to take by Chinese prescription of the present invention: Rhizoma Alismatis, Semen Cassiae, Rhizoma Dioscoreae, Fructus Lycii, Fructus Tribuli, Semen Cuscutae, gardenia florida, Radix Scutellariae, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Flos Chrysanthemi, Dendrobium nobile, Poria, Radix Paeoniae Rubra, Radix Ophiopogonis, Cortex Phellodendri, Cortex Mori, Radix Glycyrrhizae, pulverize respectively, mix;

Step 2, add the purified water of 7-10 doubly initial medical material weight, backflow decocts 2-4 hour, filters to get filtrate; In filtering residue, add the purified water of initial medical material 4-7 times weight, backflow decocts 1-3 hour, filters to get filtrate; By the mixing of twice filtrate, carry out concentrating under reduced pressure, until the relative density of mixed liquor is 1.15-1.23(70-75 DEG C of surveys) time stops concentrating, and is Chinese traditional medicine water extract;

Step 3, the medicinal residues of step 2 are added 4-7 times of weight concentration is the alcoholic solution of 55-75%, and backflow decocts 2-4 hour, filters, and once, by twice filtrate mixing, distillation removing ethanol, is Chinese medicine alcohol extract in repetitive operation;

Step 4, by Chinese traditional medicine water extract and Chinese medicine alcohol extract mixing, concentrating under reduced pressure becomes Chinese medical concrete;

Chinese medical concrete is made the finished product preparation of clinical needs by step 5, the modern general preparation technique of utilization, as dosage forms such as granule, tablet, pill, capsule, powder, syrups.

The relevant nature introduction of the present invention's Chinese crude drug used:

Rhizoma Alismatis: this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.Sweet in the mouth, cold in nature; Return kidney, urinary bladder channel; Diuresis, clearing away damp-heat.

Semen Cassiae: this product is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae.Sweet in the mouth, hardship, salty, cold nature; Return liver, large intestine channel; Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.

Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.

Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum.Sweet in the mouth, property is put down; Return liver, kidney channel; Nourishing the liver and kidney, replenishing vital essence to improve eyesight.

Fructus Tribuli: this product is the dry mature fruit of zygophyllaceae plant Fructus Tribuli.Acrid in the mouth, hardship, slightly warm in nature; Return Liver Channel; Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.

Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant.Sweet in the mouth, warm in nature; Return liver,kidney,spleen warp; Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.

Gardenia florida: this product is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.Bitter in the mouth, cold in nature; GUIXIN, lung, tri-jiao channel; Fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.

Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae.Bitter in the mouth, cold in nature; Return lung, gallbladder, spleen, large intestine, small intestine meridian; Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.

Rhizoma Cimicifugae: this product is the dry rhizome of ranunculaceae plant C.heracleifolia, Cimicifuga Dahurica or Rhizoma Cimicifugae.Acrid in the mouth, micro-sweet, cold nature; Return lung, spleen, stomach, large intestine channel; Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.

Radix Et Rhizoma Rhei: this product is the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Bitter in the mouth, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel; Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.

Flos Chrysanthemi: be the herb of the little Flos Chrysanthemi of feverfew.Bitter in the mouth; Pungent; Cold nature; Clearing heat and expelling damp.

Dendrobium nobile: the stem of orchid Dendrobium nobile.Cold in nature, sweet in the mouth, light, micro-salty; Nourishing YIN and clearing away heat, promoting the production of body fluid to quench thirst.

Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.

Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.

Radix Ophiopogonis: this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf).Sweet in the mouth, micro-hardship, cold nature; GUIXIN, lung, stomach warp; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.

Cortex Phellodendri: this product is the dry bark of rutaceae wampee or Cortex Phellodendri.Bitter in the mouth, cold in nature; Return kidney, urinary bladder channel; Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.

Cortex Mori: this product is the dry root bark of moraceae plants Mulberry.Sweet in the mouth, cold in nature; Return lung meridian; Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

The prescription analysis of Chinese medicine of the present invention:

Chinese prescription of the present invention is with Rhizoma Alismatis, Semen Cassiae, Rhizoma Cimicifugae, Rhizoma Dioscoreae, Fructus Lycii for monarch drug, clearing away heat to improve acuity of vision, delivers rash, nourishing liver and kidney, replenishing vital essence to improve eyesight; With Fructus Tribuli, Semen Cuscutae, Radix Scutellariae, Dendrobium nobile for ministerial drug, promoting blood circulation by removing wind, improving eyesight are antipruritic, dampness removing toxic substances, nourishing YIN and clearing away heat; With gardenia florida, Radix Et Rhizoma Rhei, Cortex Mori, Radix Paeoniae Rubra for adjuvant drug, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, inducing diuresis to remove edema, eliminating stasis to stop pain; With Flos Chrysanthemi, Poria, Radix Ophiopogonis, Cortex Phellodendri for making medicine, clearing heat and expelling damp, eliminating dampness and diuresis, YIN nourishing and the production of body fluid promoting, pathogenic fire purging are except steaming; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, make that all medicines are relied on for counsel each other, synergism, to complement each other, thus reach that promoting blood circulation by removing wind, improving eyesight are antipruritic, removing pathogenic heat from blood and toxic substance from the body, pathogenic fire purging except effects such as steamings, have very significant therapeutic effect to ophthalmics such as cataracts.

Compared with prior art, Chinese medicine preparation of the present invention has the advantages such as instant effect, easily radical cure, not easily recurrence in the ophthalmics such as treatment cataract, and its preparation technology is easy, efficacy stability, individual variation are little, be easy to apply, benefit more patients.

Detailed description of the invention

Embodiment 1

(1), accurately take by Chinese prescription of the present invention: Rhizoma Alismatis 1800g, Semen Cassiae 2100g, Rhizoma Dioscoreae 1100g, Fructus Lycii 1000g part, Fructus Tribuli 800g, Semen Cuscutae 1100g, gardenia florida 800g, Radix Scutellariae 1100g, Rhizoma Cimicifugae 1200g, Radix Et Rhizoma Rhei 900g, Flos Chrysanthemi 700g, Dendrobium nobile 1000g, Poria 700g, Radix Paeoniae Rubra 800g, Radix Ophiopogonis 1000g, Cortex Phellodendri 700g, Cortex Mori 900g, Radix Glycyrrhizae 900g, pulverize respectively, mix;

(2), add the purified water of 9 times of weight, backflow decoction 3 hours, filters to get filtrate; In filtering residue, add the purified water of initial medical material 6 times of weight, backflow decoction 2 hours, filters to get filtrate; By the mixing of twice filtrate, carry out concentrating under reduced pressure, until the relative density of mixed liquor is 1.19(70 DEG C of surveys) time stops concentrating, and is Chinese traditional medicine water extract;

(3), by the medicinal residues of step 2 adding 5 times of weight concentrations is the alcoholic solution of 65%, and backflow decoction 3 hours, filters, and once, by twice filtrate mixing, distillation removing ethanol, is Chinese medicine alcohol extract in repetitive operation;

(4), by Chinese traditional medicine water extract and the mixing of Chinese medicine alcohol extract, concentrating under reduced pressure becomes Chinese medical concrete;

(5), utilize modern general preparation technique that Chinese medical concrete is made capsule, amount to crude drug content and be about 0.78g crude drug/capsules.

Embodiment 2

(1), accurately take by Chinese prescription of the present invention: Rhizoma Alismatis 3200g, Semen Cassiae 3500g, Rhizoma Dioscoreae 2300g, Fructus Lycii 2200g part, Fructus Tribuli 1600g, Semen Cuscutae 2300g, gardenia florida 1600g, Radix Scutellariae 2500g, Rhizoma Cimicifugae 2800g, Radix Et Rhizoma Rhei 1900g, Flos Chrysanthemi 1700g, Dendrobium nobile 2200g, Poria 1700g, Radix Paeoniae Rubra 1800g, Radix Ophiopogonis 2200g, Cortex Phellodendri 1300g, Cortex Mori 1900g, Radix Glycyrrhizae 1500g, pulverize respectively, mix;

Embodiment 3

(1), accurately take by Chinese prescription of the present invention: Rhizoma Alismatis 1800g, Semen Cassiae 3500g, Rhizoma Dioscoreae 1100g, Fructus Lycii 2200g part, Fructus Tribuli 800g, Semen Cuscutae 2300g, gardenia florida 800g, Radix Scutellariae 2500g, Rhizoma Cimicifugae 1200g, Radix Et Rhizoma Rhei 1900g, Flos Chrysanthemi 700g, Dendrobium nobile 2200g, Poria 700g, Radix Paeoniae Rubra 1800g, Radix Ophiopogonis 100g, Cortex Phellodendri 1300g, Cortex Mori 900g, Radix Glycyrrhizae 1500g, pulverize respectively, mix;

Embodiment 4

(1), accurately take by Chinese prescription of the present invention: Rhizoma Alismatis 2500g, Semen Cassiae 2800g, Rhizoma Dioscoreae 1700g, Fructus Lycii 1600g, Fructus Tribuli 1200g, Semen Cuscutae 1700g, gardenia florida 1200g, Radix Scutellariae 1800g, Rhizoma Cimicifugae 2000g, Radix Et Rhizoma Rhei 1400g, Flos Chrysanthemi 1200g, Dendrobium nobile 1600g, Poria 1200g, Radix Paeoniae Rubra 1300g, Radix Ophiopogonis 1600g, Cortex Phellodendri 1000g, Cortex Mori 1400g, Radix Glycyrrhizae 1200g, pulverize respectively, mix;

Embodiment 5

(1), accurately take by Chinese prescription of the present invention: Rhizoma Alismatis 2700g, Semen Cassiae 3000g, Rhizoma Dioscoreae 1600g, Fructus Lycii 1800g, Fructus Tribuli 1000g, Semen Cuscutae 1600g, gardenia florida 1100g, Radix Scutellariae 1700g, Rhizoma Cimicifugae 1800g, Radix Et Rhizoma Rhei 1500g, Flos Chrysanthemi 1300g, Dendrobium nobile 1700g, Poria 1300g, Radix Paeoniae Rubra 1200g, Radix Ophiopogonis 1500g, Cortex Phellodendri 900g, Cortex Mori 1200g, Radix Glycyrrhizae 1300g, pulverize respectively, mix;

Embodiment 6

The toxicity test of Chinese medicine capsules of the present invention

(1) test drug: Chinese medicine capsules obtained by embodiment of the present invention 1-5, abolishes capsule shells, and the purified water adding 2 times amount is modulated into scattered paste shape, for subsequent use.Test animal used: regular grade NIH mice, body weight 21g ± 4g, male and female half and half, female mice is all without pregnant; SD rat, original body mass 225 ± 9g, male and female half and half, female rats is all without pregnant.

(2) acute toxicity test

Application mice carries out acute toxicity testing and shows: common mouse stomach Chinese medicine of the present invention, under 733.7g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach Chinese medicine of the present invention is 733.7g crude drug/kg/d(LD ₅₀> 733.7g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.13g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 5643.8 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.

(3), long term toxicity test

Select SD rat, give the Chinese medicine magma of the present invention of Three doses: 23.4g crude drug/kg, 7.8g crude drug/kg, 2.6g crude drug/kg(per weight dosage is by 20 times of calculating of clinical application amount, and clinical application amount is according to Pharmacopoeia of the People's Republic of China version in 2010).Every day gavage once, continuous 90 days, after last administration 24 hours respectively group live and kill 1/2 animal (male and female half and half), all the other 1/2 animals continue that observations are alive after 2 weeks kills.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal; Within after administration 90 days, within 2 weeks, carry out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.

Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test: Chinese medicine preparation of the present invention has no significant effect rat in high, medium and low three dosage (23.4g crude drug/kg, 7.8g crude drug/kg, 2.6g crude drug/kg) administration in continuous 90 days, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention very high.

Embodiment 7

The clinical effectiveness test of Chinese medicine capsules of the present invention

1, physical data is tested

Clinical trial patient used provides by certain city's ophthalmologic hospital, from this institute in 384 the cataract patients accepted for medical treatment year January in May, 2011 to 2014, select and be applicable to and be ready to coordinate the patient 128 doing clinical trial, wherein cataract 64, men and women half and half, age 51-79 year, glaucoma patient 64, men and women half and half, age 26-66 year.128 patients are divided into 4 groups, and often organize 32, men and women half and half.Be respectively test 1 group (two: cataract group, glaucoma groups), test 2 groups (two: cataract group, glaucoma groups).

Test drug is the embodiment of the present invention 4, Chinese medicine capsules obtained by embodiment 5.

2, test method

Test 1 group of made capsule of the oral embodiment of the present invention 4, test 2 groups of made capsules of the oral embodiment of the present invention 5, be every day twice, each 5, amounting to crude drug amount is 3.9g/ time, within 2 weeks, is a course for the treatment of, treats 4 courses for the treatment of continuously; In process of the test record patient take medicine after changes of vital signs, after 6 months, return visit is followed the tracks of to healing person's drug withdrawal, record recurrent cases.

3, evaluation criterion

Cure: all feature diseases of cataract disappear completely, eyes recover normal, make a definite diagnosis rehabilitation through doctor.

Effective: cataract part disease disappears or alleviates, and still needs continual cure.

Invalid: the symptom of cataract does not obtain any improvement, even more serious.

Recurrence: the disease of healing person before drug withdrawal suffers from healing in 6 months again.

4, result of the test

(1), changes of vital signs after medication: after taking medicine, a routine untoward reaction does not all appear in all experimenters; Patient's eye after taking medicine three days starts to feel there is obvious comfort, and somatosensory is more pleasant; Cure patient and feel that the light body of body is good for, middle gas foot.

(2), test data statistical analysis:

After test all completes, data statistic analysis is as shown in table 1:

Table 1 test data statistical analysis table

5, conclusion

The many employing operations of current treatment cataract or laser, patient suffering is large, the treatments such as glaucoma many employings vitamin, poor effect.In this case, observe clinical test results of the present invention will find, capsule of the present invention is without any side effects, take into account conditioning patient body constitution, reach 48.5% to cataractous average cure rate, average total effective rate is 98.5%, and almost 100% is effective, in two groups 31 patients cured, only there is 1 routine Patients on Recurrence; For glaucomatous treatment, average cure rate reaches 57.4% especially, and total effective rate is 100%, without recurrent cases.Therefore, Chinese medicine preparation of the present invention has very significant technical advantage, obtains beyond thought therapeutic effect.

Claims

1. treat a Chinese medicine preparation for cataract, it is characterized in that the Chinese prescription of described Chinese medicine preparation is obtained by following weight portion Chinese crude drug: Rhizoma Alismatis 18-32 part, Semen Cassiae 21-35 part, Rhizoma Dioscoreae 11-23 part, Fructus Lycii 10-22 part, Fructus Tribuli 8-16 part, Semen Cuscutae 11-23 part, gardenia florida 8-16 part, Radix Scutellariae 11-25 part, Rhizoma Cimicifugae 12-28 part, Radix Et Rhizoma Rhei 9-19 part, Flos Chrysanthemi 7-17 part, Dendrobium nobile 10-22 part, Poria 7-17 part, Radix Paeoniae Rubra 8-18 part, Radix Ophiopogonis 10-22 part, Cortex Phellodendri 7-13 part, Cortex Mori 9-19 part, Radix Glycyrrhizae 9-15 part.

2. one according to claim 1 treats cataract, glaucomatous Chinese medicine preparation, it is characterized in that the Chinese prescription of described Chinese medicine preparation is obtained by following weight portion Chinese crude drug: Rhizoma Alismatis 20-30 part, Semen Cassiae 25-30 part, Rhizoma Dioscoreae 12-20 part, Fructus Lycii 12-20 part, Fructus Tribuli 10-14 part, Semen Cuscutae 12-20 part, gardenia florida 9-15 part, Radix Scutellariae 13-23 part, Rhizoma Cimicifugae 15-26 part, Radix Et Rhizoma Rhei 9-17 part, Flos Chrysanthemi 8-14 part, Dendrobium nobile 12-21 part, Poria 9-14 part, Radix Paeoniae Rubra 10-17 part, Radix Ophiopogonis 11-21 part, Cortex Phellodendri 7-10 part, Cortex Mori 11-14 part, Radix Glycyrrhizae 10-15 part.

3. a kind of Chinese medicine preparation for the treatment of cataract according to claim 2, is characterized in that the Chinese prescription of described Chinese medicine preparation is obtained by following weight portion Chinese crude drug: Rhizoma Alismatis 25 parts, Semen Cassiae 28 parts, Rhizoma Dioscoreae 17 parts, Fructus Lycii 16 parts, Fructus Tribuli 12 parts, Semen Cuscutae 17 parts, gardenia florida 12 parts, Radix Scutellariae 18 parts, Rhizoma Cimicifugae 20 parts, Radix Et Rhizoma Rhei 14 parts, Flos Chrysanthemi 12 parts, Dendrobium nobile 16 parts, 12 parts, Poria, Radix Paeoniae Rubra 13 parts, Radix Ophiopogonis 16 parts, Cortex Phellodendri 10 parts, Cortex Mori 14 parts, 12 parts, Radix Glycyrrhizae.

4. a kind of Chinese medicine preparation for the treatment of cataract according to claim 2, is characterized in that the Chinese prescription of described Chinese medicine preparation is obtained by following weight portion Chinese crude drug: Rhizoma Alismatis 27 parts, Semen Cassiae 30 parts, Rhizoma Dioscoreae 16 parts, Fructus Lycii 18 parts, Fructus Tribuli 10 parts, Semen Cuscutae 16 parts, gardenia florida 11 parts, Radix Scutellariae 17 parts, Rhizoma Cimicifugae 18 parts, Radix Et Rhizoma Rhei 15 parts, Flos Chrysanthemi 13 parts, Dendrobium nobile 17 parts, 13 parts, Poria, Radix Paeoniae Rubra 12 parts, Radix Ophiopogonis 15 parts, Cortex Phellodendri 9 parts, Cortex Mori 12 parts, 13 parts, Radix Glycyrrhizae.

5. a kind of preparation method for the treatment of the Chinese medicine preparation of cataract as described in as arbitrary in claim 1-4, is characterized in that comprising the following steps:

(1) Rhizoma Alismatis, Semen Cassiae, Rhizoma Dioscoreae, Fructus Lycii, Fructus Tribuli, Semen Cuscutae, gardenia florida, Radix Scutellariae, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Flos Chrysanthemi, Dendrobium nobile, Poria, Radix Paeoniae Rubra, Radix Ophiopogonis, Cortex Phellodendri, Cortex Mori, Radix Glycyrrhizae is accurately taken by Chinese prescription of the present invention, pulverize respectively, mix;

(2) add the purified water of 7-10 times of initial medical material weight, backflow decocts 2-4 hour, filters to get filtrate; In filtering residue, add the purified water of initial medical material 4-7 times weight, backflow decocts 1-3 hour, filters to get filtrate; By twice filtrate mixing, carrying out concentrating under reduced pressure, until the relative density of mixed liquor is concentrated for stopping during 1.15-1.23 at 70-75 DEG C, being Chinese traditional medicine water extract;

(3) medicinal residues of step (2) being added 4-7 times of weight concentration is the alcoholic solution of 55-75%, and backflow decocts 2-4 hour, filters, and once, by twice filtrate mixing, distillation removing ethanol, is Chinese medicine alcohol extract in repetitive operation;

(4) by Chinese traditional medicine water extract and the mixing of Chinese medicine alcohol extract, concentrating under reduced pressure becomes Chinese medical concrete;

(5) modern general preparation technique is utilized Chinese medical concrete to be made the finished product preparation of clinical needs.

6. a kind of Chinese medicine preparation for the treatment of cataract as described in as arbitrary in claim 1-4, is characterized in that: described Chinese medicine preparation can make granule, tablet, pill, capsule, powder and syrup.