CN104906313A

CN104906313A - Medicine for treating Qi-stagnation and blood-stasis type occupational chronic lead poisoning and preparation method thereof

Info

Publication number: CN104906313A
Application number: CN201510336755.3A
Authority: CN
Inventors: 周镔
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-17
Filing date: 2015-06-17
Publication date: 2015-09-16

Abstract

The invention discloses a medicine for treating Qi-stagnation and blood-stasis type occupational chronic lead poisoning and a preparation method thereof. The medicine comprises the following raw materials: Dahongpao tea, rhizoma corydalis decumbentis, radix aconiti, oldenlandia diffusa, calamint, aconiteleaf syndeilesis herb, herba aristolochiae mollissimae, Chinese redbud bark, glabrous sarcandra herb, dioscorea esquirolii Prain et Burkill, metaplexis japonica, coffee senna seed, angelica, citrus trunk borer larva, branchy paliurus fruit, hygrophila salicifolia, chickweed, fortune firethorn root, climbing fig, myrtle, amorphallus virosus N.e.Brown, tsingling bergenia rhizome, forestry greenstar root, centella, Asiatic moonseed rhizome, ghostplant wormwood herb, agastache, polygalae japonicae herba, Siberian veronicastrum herb, turnip seed and liquorice. The medicine has the beneficial effects as follows: the medicine employs traditional Chinese medicines which have different properties and are combined scientifically, can promote the circulation of qi, disperse blood stasis, remove toxin, relieve pain, speed up the expelling of toxin and treat both symptoms and root causes, is safe and effective, and has few untoward effects and a relatively short treatment course; and the medicine has a simple and convenient preparation process, is low in cost, and avoids easy recurrence after recovery.

Description

The medicine for the treatment of qi stagnation and blood stasis type occupational chronic lead poisoning and preparation method

Technical field

The present invention relates to pharmaceutical technology, particularly treat medicine and the preparation method of qi stagnation and blood stasis type occupational chronic lead poisoning.

Background technology

Lead is one of the most ancient poisonous substance of human knowledge, and lead poisoning is also common occupation disease.Improving constantly and the fast development of economy in recent years along with social science and technology's level, professional lead poisoning case showed increased.Lead poisoning often causes human body multiple organ system damage, mainly lead enters blood circulation after being absorbed with ionic condition, mainly at first respectively to organize in whole body with lead salt and the formal distribution that is combined with plasma protein, 95% is about had to be deposited on skeletal system and hair with insoluble lead phosphate after several weeks, only there is the lead of about 5% to retain in the organs such as liver, kidney, brain and blood, cause anemia, haemolysis, lead encephalopathy and peripheral neuropathy and kidney injury.

Occupational Exposure is common in plumbous smelting, alloy manufacturing industry, accumulator industry, printing typeofounding, metal solder and fusion cutting, lead, radio component and sprays lead, bearing tile hanging, pottery, cloisonné technique, pigment industry and rubber plastic industry etc.These operations are after the flue dust sucking plumbous and compound mostly, enter human body and poisoning by pulmonary circulation.There is explicit stipulation in country to the maximum permissible concentration of harmful substance in workshop air, and as workshop lead fume content should lower than 0.03mg/m3, lead dust should lower than 0.05mg/m3.Some production station then often exceeds this normal concentration, even exceedes this concentration several times or decades of times.Most personal entity lead refinery and printing industry condition simple and crude, to occupational hazards protection aspect less investment, various occupational health management system and protective equipment unsound, production environment is poor, add that worker lacks self-protection consciousness, do not note Personal hygiene thus cause professional lead poisoning.

Angina abdominis is saturnine characteristic symptom.Often break out, how in umbilicus week, in persistence, paroxysm aggravates, hurt like hell, often bends over to bend knee, toss about in bed rolling, companion's pale complexion, whole body cold sweat.Abdomen examination is often without obvious sign, and pain relieved by pressing, has light tenderness, hypoactive bowel sounds sometimes.Show effect sustainable several minutes to a few hours, can automatically alleviate.Angina abdominis is that patient seeks medical advice or the main cause of emergency treatment.Now should note with various acute abdomen as discriminatings such as biliary diseases, pancreatitis, gastric perforation, peritonitis, appendicitis, ureteral calculus, hematoporphyria and gynecological diseases.Severe lead poisoning can cause obvious nervous system damage, and main manifestations is toxic encephalopthy and peripheral neuropathy.Be more common in liveliness proof lead poisoning.The former shows severe headache, and Nausea and vomiting, agitation, tic, drowsiness, mental disorder, epilepsy are so that stupor etc.This situation is extremely rare clinically at present, and lead peripheral neuropathy mostly is motor type and mixed type obstacle.Performance grip goes down, weakness of the lower extremities, and muscular paralysis forms hang down wrist or intersection point, is called " plumbous paralysis ".This kind of performance should note with general, comprise infectious peripheral neuropathy and differentiate mutually.

Different according to poisoning rear performance, the traditional Chinese medical science is divided into following a few type: qi stagnation and blood stasis type, incoordination between the spleen and stomach type, spleen-stomach deficiency-cold, qi and blood deficiency and liver-kidney yin deficiency.

1, qi stagnation and blood stasis type: have a headache with the fluctuation of feelings will and change.Have a headache and prolongedly not heal, sore spot is fixing, and as acupuncture, often with stomachache, pain spot is fixed, and tenderness, purplish tongue, pulse condition band is puckery.

2, incoordination between the spleen and stomach type: distension and fullness in the abdomen, belch, singultus, poor appetite, pale tongue with white fur band are greasy, stringy and hesitant pulse.

3, spleen-stomach deficiency-cold: lack of appetite singultus, vomiting clear water, stomachache indistinctly, likes hot aversion to cold, hands and feet being not warm, diarrhea with loose stool, pale complexion, pale tongue with white fur, and deficient pulse delays.

4, qi and blood deficiency: have a dizzy spell, palpitation and insomnia, spiritlessness and sparing of words, pale complexion, lip and nail are not magnificent, light red tongue white, thready and weak pulse without strength.

5, liver-kidney yin deficiency: dizziness and tinnitus, insomnia forgetfulness, being irritable and getting angry easily, soreness of the waist and knees, seminal emission, the few Tianjin of red tongue xerostomia, stringy and thready pulse.

Western medical treatment lead poisoning mainly drives plumbous method, is simultaneously easily discharged together by other trace element.

Chinese medicine lead poisoning utilizes Traditional Chinese medical theory, the ability of enhancing body defence pathogenic factor, and solid protection healthy energy, passes through determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, get rid of toxin, alleviate the toxic and side effects of western modern medicine, treating both the principal and secondary aspects of a disease, safe and effective, untoward reaction is less, and the course for the treatment of is shorter, convenient drug administration, and patient is easy to accept.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of medicine with promoting the circulation of QI dissipating blood stasis, removing toxic substances analgesic efficacy, is used for the treatment of qi stagnation and blood stasis type occupational chronic lead poisoning.The present invention utilizes Traditional Chinese medical theory, the ability of enhancing body defence pathogenic factor, and get rid of toxin, alleviate the toxic and side effects of western modern medicine, treating both the principal and secondary aspects of a disease, safe and effective, untoward reaction is less, and treatment time is shorter, convenient drug administration, and patient is easy to accept, and improves cure rate.

In order to realize foregoing invention object, the invention provides a kind of medicine for the treatment of qi stagnation and blood stasis type occupational chronic lead poisoning, it is characterized in that, comprise following raw medicinal material: Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani, Herba Hedyotidis Diffusae, Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae, to enrich blood potato, Herba seu radix metaplexis, Semen Cassiae Occidemtalis, Radix Angelicae Sinensis, Tinea Anoplophorae seu Aprionae, Fructus paliuri ramosissimi, Hygrophila salicifolia, Herba stellariae mediae, Radix Pyracanthae Fortuneanae, Caulis fici pumilae (Fructus Fici Pumilae), Fructus Rhodomyrti, Rhizoma Amorphophalli virosi, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C., Herba Centellae, Rhizoma Menispermi, Herba artemisiae lactiflorae, Herba Pogostemonis, Herba Polygalae Japonicae, Herba Veronicastri Sibirici, Semen Brassicae Rapae and Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 15-25 part, Rhizoma Corydalis Decumbentis 10-22 part, Radix aconiti szechenyiani 2-5 part, Herba Hedyotidis Diffusae 20-38 part, Herba Clinopodii Polycephali 12-24 part, Herba Syneilesis Aconitifoliae 3-7 part, Herba Aristolochiae Mollissimae 10-25 part, Cortex cercis chinensis 2-6 part, Herba Sarcandrae 6-12 part, to enrich blood potato 18-33 part, Herba seu radix metaplexis 13-27 part, Semen Cassiae Occidemtalis 4-7 part, Radix Angelicae Sinensis 28-40 part, Tinea Anoplophorae seu Aprionae 10-18 part, Fructus paliuri ramosissimi 22-29 part, Hygrophila salicifolia 14-22 part, Herba stellariae mediae 19-27 part, Radix Pyracanthae Fortuneanae 10-25 part, Caulis fici pumilae (Fructus Fici Pumilae) 12-25 part, Fructus Rhodomyrti 12-18 part, Rhizoma Amorphophalli virosi 10-25 part, Rhizoma Bergeniae scopulosae 12-17 part, Polyalthia nemoralis A. D C. 10-18 part, Herba Centellae 16-24 part, Rhizoma Menispermi 10-20 part, Herba artemisiae lactiflorae 21-26 part, Herba Pogostemonis 16-30 part, Herba Polygalae Japonicae 13-23 part, Herba Veronicastri Sibirici 12-22 part, Semen Brassicae Rapae 16-25 part and Radix Glycyrrhizae 11-19 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 16-23 part, Rhizoma Corydalis Decumbentis 11-20 part, Radix aconiti szechenyiani 2-4 part, Herba Hedyotidis Diffusae 22-35 part, Herba Clinopodii Polycephali 13-22 part, Herba Syneilesis Aconitifoliae 4-6 part, Herba Aristolochiae Mollissimae 11-24 part, Cortex cercis chinensis 3-5 part, Herba Sarcandrae 7-10 part, to enrich blood potato 19-31 part, Herba seu radix metaplexis 15-24 part, Semen Cassiae Occidemtalis 4-6 part, Radix Angelicae Sinensis 29-37 part, Tinea Anoplophorae seu Aprionae 12-16 part, Fructus paliuri ramosissimi 24-27 part, Hygrophila salicifolia 15-21 part, Herba stellariae mediae 20-25 part, Radix Pyracanthae Fortuneanae 12-22 part, Caulis fici pumilae (Fructus Fici Pumilae) 14-23 part, Fructus Rhodomyrti 13-16 part, Rhizoma Amorphophalli virosi 11-23 part, Rhizoma Bergeniae scopulosae 13-15 part, Polyalthia nemoralis A. D C. 12-16 part, Herba Centellae 18-21 part, Rhizoma Menispermi 13-18 part, Herba artemisiae lactiflorae 21-24 part, Herba Pogostemonis 18-26 part, Herba Polygalae Japonicae 15-21 part, Herba Veronicastri Sibirici 13-20 part, Semen Brassicae Rapae 17-24 part and Radix Glycyrrhizae 12-18 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 16 parts, Rhizoma Corydalis Decumbentis 20 parts, Radix aconiti szechenyiani 3 parts, Herba Hedyotidis Diffusae 28 parts, Herba Clinopodii Polycephali 13 parts, Herba Syneilesis Aconitifoliae 5 parts, Herba Aristolochiae Mollissimae 15 parts, Cortex cercis chinensis 5 parts, Herba Sarcandrae 9 parts, to enrich blood potato 31 parts, Herba seu radix metaplexis 20 parts, Semen Cassiae Occidemtalis 4 parts, Radix Angelicae Sinensis 32 parts, Tinea Anoplophorae seu Aprionae 14 parts, Fructus paliuri ramosissimi 27 parts, Hygrophila salicifolia 19 parts, Herba stellariae mediae 25 parts, Radix Pyracanthae Fortuneanae 14 parts, Caulis fici pumilae (Fructus Fici Pumilae) 23 parts, Fructus Rhodomyrti 13 parts, Rhizoma Amorphophalli virosi 23 parts, 15 parts, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C. 12 parts, Herba Centellae 21 parts, Rhizoma Menispermi 13 parts, Herba artemisiae lactiflorae 24 parts, Herba Pogostemonis 18 parts, Herba Polygalae Japonicae 17 parts, Herba Veronicastri Sibirici 13 parts, Semen Brassicae Rapae 24 parts and 12 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 23 parts, Rhizoma Corydalis Decumbentis 17 parts, Radix aconiti szechenyiani 2 parts, Herba Hedyotidis Diffusae 22 parts, Herba Clinopodii Polycephali 17 parts, Herba Syneilesis Aconitifoliae 6 parts, Herba Aristolochiae Mollissimae 11 parts, Cortex cercis chinensis 4 parts, Herba Sarcandrae 10 parts, to enrich blood potato 26 parts, Herba seu radix metaplexis 24 parts, Semen Cassiae Occidemtalis 5 parts, Radix Angelicae Sinensis 37 parts, Tinea Anoplophorae seu Aprionae 16 parts, Fructus paliuri ramosissimi 24 parts, Hygrophila salicifolia 21 parts, Herba stellariae mediae 23 parts, Radix Pyracanthae Fortuneanae 12 parts, Caulis fici pumilae (Fructus Fici Pumilae) 18 parts, Fructus Rhodomyrti 16 parts, Rhizoma Amorphophalli virosi 11 parts, 13 parts, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C. 14 parts, Herba Centellae 18 parts, Rhizoma Menispermi 18 parts, Herba artemisiae lactiflorae 23 parts, Herba Pogostemonis 26 parts, Herba Polygalae Japonicae 21 parts, Herba Veronicastri Sibirici 16 parts, Semen Brassicae Rapae 22 parts and 13 parts, Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 19 parts, Rhizoma Corydalis Decumbentis 11 parts, Radix aconiti szechenyiani 4 parts, Herba Hedyotidis Diffusae 35 parts, Herba Clinopodii Polycephali 22 parts, Herba Syneilesis Aconitifoliae 4 parts, Herba Aristolochiae Mollissimae 24 parts, Cortex cercis chinensis 3 parts, Herba Sarcandrae 7 parts, to enrich blood potato 19 parts, Herba seu radix metaplexis 15 parts, Semen Cassiae Occidemtalis 6 parts, Radix Angelicae Sinensis 29 parts, Tinea Anoplophorae seu Aprionae 12 parts, Fructus paliuri ramosissimi 26 parts, Hygrophila salicifolia 15 parts, Herba stellariae mediae 22 parts, Radix Pyracanthae Fortuneanae 22 parts, Caulis fici pumilae (Fructus Fici Pumilae) 14 parts, Fructus Rhodomyrti 15 parts, Rhizoma Amorphophalli virosi 15 parts, 14 parts, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C. 16 parts, Herba Centellae 20 parts, Rhizoma Menispermi 16 parts, Herba artemisiae lactiflorae 21 parts, Herba Pogostemonis 23 parts, Herba Polygalae Japonicae 15 parts, Herba Veronicastri Sibirici 20 parts, Semen Brassicae Rapae 17 parts and 18 parts, Radix Glycyrrhizae.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the medicine of qi stagnation and blood stasis type occupational chronic lead poisoning, and when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the medicine of qi stagnation and blood stasis type occupational chronic lead poisoning, and when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step: Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani and Herba Hedyotidis Diffusae are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stir 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step: Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae, potato of enriching blood, Herba seu radix metaplexis, Semen Cassiae Occidemtalis and Radix Angelicae Sinensis are mixed in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step: will remain described raw medicinal material and mix in described ratio, adds relative to mixture 8 ~ 10 times of water gagings, boils 6 ~ 8 hours, filters, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step: mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step: dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the medicine of qi stagnation and blood stasis type occupational chronic lead poisoning, and when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

The first step, Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani and Herba Hedyotidis Diffusae are mixed in proportion to obtain mixture one, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 ~ 5 times of mixture one quality;

Second step, is mixed in proportion Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae, potato of enriching blood, trailing plants Mi, Semen Cassiae Occidemtalis and Radix Angelicae Sinensis, is ground into powder;

3rd step, adds the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

For solving the problems of the technologies described above, the present invention also provides a kind of medicine for the treatment of qi stagnation and blood stasis type occupational chronic lead poisoning, and pharmaceutical dosage form is: tablet, film coated tablet, enteric coated tablet, sugar coated tablet, capsule, soft capsule, oral liquid, hard capsule, suck agent, electuary, honey pill agent, granule, powder, sublimed preparation, solution, syrup, ointment, injection, liniment, ointment, fumigant, patch, suppository, tincture, plaster, gel and spray.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention, adopts the Chinese crude drug of different properties, carries out scientific compatibility, can promoting the circulation of QI dissipating blood stasis, removing toxic substances pain relieving, accelerates poisonous substance excretion, treating both the principal and secondary aspects of a disease, safe and effective, untoward reaction is less, and the course for the treatment of is shorter, and pharmaceutical production simple process, with low cost, not easily recur after healing.

Detailed description of the invention

Occupational chronic lead poisoning pathogenesis is mainly after lead is absorbed with ionic condition and enters blood circulation, mainly at first respectively to organize in whole body with lead salt and the formal distribution that is combined with plasma protein, 95% is about had to be deposited on skeletal system and hair with insoluble lead phosphate after several weeks, only there is the lead of about 5% to retain in the organs such as liver, kidney, brain and blood, cause anemia, haemolysis, lead encephalopathy and peripheral neuropathy and kidney injury.

Qi stagnation and blood stasis type is that evil poison hindered, and disorder of QI movement, the stagnation of QI and having a pain, with the passing of time the stagnation of QI does not heal, and can cause sluggishness or stagnation of blood circulation, ties in blood stasis.Therefore the present invention treats qi stagnation and blood stasis type occupational chronic lead poisoning, for primary treatment principle, therefore prescription is selected: Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani, Herba Hedyotidis Diffusae, Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae, potato of enriching blood, Herba seu radix metaplexis, Semen Cassiae Occidemtalis, Radix Angelicae Sinensis, Tinea Anoplophorae seu Aprionae, Fructus paliuri ramosissimi, Hygrophila salicifolia, Herba stellariae mediae, Radix Pyracanthae Fortuneanae, Caulis fici pumilae (Fructus Fici Pumilae), Fructus Rhodomyrti, Rhizoma Amorphophalli virosi, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C., Herba Centellae, Rhizoma Menispermi, Herba artemisiae lactiflorae, Herba Pogostemonis, Herba Polygalae Japonicae, Herba Veronicastri Sibirici, Semen Brassicae Rapae and Radix Glycyrrhizae with promoting the circulation of QI dissipating blood stasis, removing toxic substances pain relieving.

Wherein, Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani, Herba Hedyotidis Diffusae, Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae are invigorated blood circulation; To enrich blood potato, Herba seu radix metaplexis, Semen Cassiae Occidemtalis, Chinese angelica blood supplementing; Tinea Anoplophorae seu Aprionae, Fructus paliuri ramosissimi, Hygrophila salicifolia, Herba stellariae mediae, Radix Pyracanthae Fortuneanae blood-activating analgetic; Caulis fici pumilae (Fructus Fici Pumilae), Fructus Rhodomyrti promoting blood circulation and detoxication; Rhizoma Amorphophalli virosi, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C. strengthen the spleen and stomach double the kidney invigorating; Herba Centellae, Rhizoma Menispermi, Herba artemisiae lactiflorae regulating QI to expel dampness; Herba Pogostemonis, Herba Polygalae Japonicae, Herba Veronicastri Sibirici removing toxic substances pain relieving; Semen Brassicae Rapae nourishing the liver is detoxified; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Campylotropis Hirtella (Herba Myrsines Africanae): call large and red, Radix Campylotropis hirtellae, oily root, flat Fructus Gleditsia.For the Dou Ke Jing tip platymiscium Mao Jing tip, be used as medicine with root.Micro-hardship, puckery, warm.Regulating menstruation and activating blood, pain relieving, convergence.For amenorrhea, dysmenorrhea, leucorrhea, stomachache; External is harnessed the Yellow River chickenpox, burn and scald.Invigorate blood circulation, dispel the wind, reason is wet.Dispelling the wind and dampness pathogens arthralgia pain, has loose bowels, dysentery, stranguria with blood, impairment caused by overstrain hemoptysis.

Rhizoma Corydalis Decumbentis: this product is the dry tuber of bloodroot Hotseason grow.Bitter, micro-pungent, temperature.Return Liver Channel.Promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.For apoplectic hemiplegia, injury from falling down, rheumatic arthritis, sciatica.

Radix aconiti szechenyiani: another name 800 rods, Radix aconiti szechenyiani, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani).Ranunculaceae aconitum plant Radix aconiti szechenyiani and Aconitum flavum Hand-Mazz, be used as medicine with tuber.Bitter, pungent, temperature.Wind-expelling pain-stopping, dissipating blood stasis stops blooding, detumescence and drawing out poison.For rheumatic arthritis, lumbago and skelalgia, traumatic injury; Tuberculous lymphadenitis (not breaking) is controlled in external, carbuncle pyogenic infections from tumour or sore.

Herba Hedyotidis Diffusae: call Herba Hedyotidis Diffusae, tang Huang, Serpentis needle grass, Radix Picriae felterrae, two leaf humulus, spend cross grass in vain, sharp knife grass, JIAMENGCAO, Herba Otteliae Alismoidis, Serpentis Lei are careless, crane SHECAO.This product is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae.Lightly seasoned, cool.Enter stomach, large intestine, small intestine meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.

Herba Clinopodii Polycephali: it is careless that another name lands Flos Mume, nine tower grass, red nine tower flowers, bear gall grass, wild Herba mesonae chinensis, bitter cutter.Labiatae Clinopodium plant Herba Clinopodii Polycephali, with all herbal medicine.Pungent, bitter, cool.Wind and heat dispersing, removing toxic substances dysentery relieving, hemostasis.For flu, heatstroke, dysentery, hepatitis; Furuncle swelling toxin, skin pruritus, traumatic hemorrhage are controlled in external.

Herba Syneilesis Aconitifoliae: another name umbrella dish, Rhizoma Arisaematis, Shui Ezhang.Compositae Herba Syneilesis Aconitifoliae platymiscium Herba Syneilesis Aconitifoliae, with root or all herbal medicine.Toil, temperature.Wind-damp dispelling, relaxing muscles and tendons to promote blood circulation, pain relieving.For lumbago and skelalgia, traumatic injury.1. herbal for Relief of Famines: " bitter in the mouth is micro-pungent." 2. " Guizhou folk medicine ": " slightly warm in nature, acrid in the mouth is nontoxic." [function cures mainly] expelling wind and removing dampness, removing toxic substances is invigorated blood circulation, reducing swelling and alleviating pain.Dispelling the wind and dampness pathogens is numb, arthralgia, and carbuncle skin ulcer swells, traumatic injury.

Herba Aristolochiae Mollissimae: the ground part of Aristolochiaceae herbaceous plant Aristolochia mollissima.Pungent, bitter, flat.Return Liver Channel.Dispelling wind and removing obstruction in the collateral, pain relieving.For rheumatic arthralgia, stomachache, cover ball swells and ache, the diseases such as traumatic pain.

Cortex cercis chinensis: Magnoliaceae Kadsura Fructus Schisandrae Sphenantherae; The bark of lagerstroemia Lagerstroemia indica L. and pulse family redbud cercis etc.Hardship, flat.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter liver, spleen two warp." 2. " detailed outline ": " starts with, sufficient cloudy blood system of fainting." promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, removing toxic substances.For menoxenia, dysmenorrhea, amenorrhea is suffered from abdominal pain, rheumatic arthritis, traumatic injury, laryngopharynx swelling and pain; Swelling and pain of hemorrhoid is controlled in external, worm venom.Promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating.Control anemofrigid-damp arthralgia, women's amenorrhea, vim and vigour pain, sore throat, drench disease, carbuncle, tinea scabies, traumatic injury, snake bite and insect sting.

Herba Sarcandrae: another name synthetism chu lan tree, Herba Pileae Scriptae, Psychotria rubra (Lour.) Poir. flower, Herba Pileae Scriptae, ring tea, synthetism lotus.This product is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye.Bitter, pungent, flat.GUIXIN, Liver Channel.Clearing away heat and cooling blood, speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.For heat in blood purpura, purpura, rheumatic arthralgia, traumatic injury.

To enrich blood potato: call seven leaf potatos, Herba Wedeliae Wallichii, seven pawls gold dragons.Medical material Ji Yuan: be the tuber of Dioscoreaceae plant seven leaf Rhizoma Dioscoreae.Pungent; Micro-sweet; Cool.Removing stasis to stop bleeding; Reducing swelling and alleviating pain.Main impairment of the lung caused by overstrain hemoptysis; Hepatosplenomegaly; Dysmenorrhea; Puerperal abdonimal pain; Traumatic injury.

Herba seu radix metaplexis: another name Bai Huanteng, Herba seu Radix Metaplexis hemsleyanae, Pericarpium Metaplexis, grandmother's sewing kit, Metaplexis japonica (Thunb.)Makino.Asclepiadaceae Herba seu radix metaplexis platymiscium Herba seu radix metaplexis, is used as medicine with tuber, herb and shell.Root: sweet, temperature.Shell: pungent, temperature.Herb: sweet, micro-pungent, temperature.Root: QI invigorating benefit essence.For having a delicate constitution, sexual impotence, leucorrhea, hypogalactia, infantile malnutrition; Furuncle is controlled in external, agkistrodon acutus bite.Shell: tonify deficiency is supporing yang, relieving cough and resolving phlegm.For having a delicate constitution, phlegm dyspnea is coughed, pertussis, sexual impotence, seminal emission; Wound hemorrhage (pasting affected part with kind of hair) is controlled in external.Herb: strong, promoting flow of QI and blood, subduing swelling and detoxicating.For emission due to deficiency of the kidney, hypogalactia; Furuncle toxic swelling is controlled in external, worm, venom.The present invention's herb.

Semen Cassiae Occidemtalis: another name Semen sophorae (herbal for Relief of Famines), the sub-bean of pheasant (" Fujian traditional herbal medicine "), gold silver coin, golden angle youngster (" medicine will is planted in Jiangsu "), south of the River bean (" illustrated handbook planted by middle traditional Chinese medicines "), water pawl bean (" register planted by Guangxi medicine "), wind and cold bean, yellow Semen vignae sinensis (" Jiangsu medical material will ").The pod that [source] is leguminous plant Herba cassiae occidentalis or seed.Sweetness and bitterness, cool.1. " modern Practical Chinese medicinal ": " bitter, flat, nontoxic." 2. " Fujian traditional herbal medicine ": " is bitter, is slightly cold, nontoxic." 3. " Guangxi Chinese medicinal herbal ": " micro-sweetness and bitterness of taste, property is put down." 4. " Fujian Chinese herbal medicine ": " Gan Xin is cool." [function cures mainly] liver heat removing and eyesight improving, stomach invigorating, relieving constipation, removing toxic substances.Control conjunctival congestion and swelling pain, dizzy feeling of fullness in the head, dyspepsia, stomachache, stomachache, dysentery, constipation.

Herba Pyrolae: another name Herba pyrolae japonicae, Herba Pyrolae, deer peace tea, Herba pyrolae japonicae, checkerberry, Pyrola rotundifolia ssp.chinensis, Herba Polygalae Telephioidis [Sichuan].This product is the dry herb of Pyrolaceae plant Herba pyrolae japonicae or ovum leaf Herba pyrolae japonicae.Sweet, bitter, temperature.[return through] returns liver, kidney channel.[function cures mainly] wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.

Radix Angelicae Sinensis: sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Tinea Anoplophorae seu Aprionae: another name Mulberry scorpion, longicorn's larva, cone drums worm, roundheaded borer, brown longicorn beetle, mulberry borer, Sang Niu, Kazakhstan cattle.Insecta coleoptera Cerambycidae Tinea Anoplophorae seu Aprionae, is used as medicine with larva in channel.Sweet, temperature.Strong blood circulation and promoting silt medicine, and have the merit of spasmolytic, analgesia.Cure mainly amenorrhea, metrorrhagia, leucorrhea with red and white discharge, agalactia, children's's variola does not go out, and infantile convulsion is twitched, and gets injured by a fall blood stasis, pain along the spinal column, the full pain of trusted subordinate's QI and blood heavily fortified point.

Fructus paliuri ramosissimi: be the fruit of Rhamnaceae plant waistcoat.Bitter in the mouth; Sweet; Warm in nature.Removing stasis to stop bleeding; Promoting blood circulation and stopping pain.Haematemesis caused by main blood stasis; Epistaxis; Have blood in stool; Dysmenorrhea; Amenorrhea; Trusted subordinate's pain; Swelling and pain of hemorrhoid.

Hygrophila salicifolia: another name punching Serpentis, fishbone grass, Psychotria rubra (Lour.) Poir. flower, black dish.Acanthaceae Hygrophila vegetation water straw rain cape is with all herbal medicine.Sweet, micro-hardship, cool.Heat-clearing and toxic substances removing, blood-activating analgetic.For pharyngolaryngitis, mastitis, spit blood, epistaxis, pertussis; Fracture is controlled in external, traumatic injury, venom.

Herba stellariae mediae: another name goose intestinal, Intestinum Gallus domesticus dish, conjunction muscle grass, Herba Cucubali, garden sauerkraut.Caryophyllaceae Stellaria plant Herba stellariae mediae, with all herbal medicine.Sweet, sour, cool.Heat-clearing and toxic substances removing, blood-activating analgetic, lactogenic.For enteritis, dysentery, hepatitis, appendicitis, postnatal blood stasis is suffered from abdominal pain, uterine contraction pain, toothache, early whitening of hair, agalactia, mastitis, traumatic injury, sore swollen toxin.

Radix Pyracanthae Fortuneanae: another name torch fruit root.For the root of rosaceous plant fire sour jujube.Acid; Puckery; Flat; Nontoxic.Return liver; Kidney channel.Clearing away heat and cooling blood, blood-activating analgetic.Main hectic fever night sweat, discharging fresh blood stool, metrorrhagia, furuncle carbuncle pain, conjunctival congestion and swelling pain, acute toothache, traumatic injury, impairment caused by overstrain lumbago, traumatic hemorrhage.

Caulis fici pumilae (Fructus Fici Pumilae): another name Fructus Fici Pumilae rattan (" Japan hanako materia medica "), ward off calyx (" interrogating book on Chinese herbal medicine "), cliff lotus (" plant name remittance "), common floweringqince vine, swollen bubble tree, cake bubble tree, wall stone tiger, Mu Bilian (" Chinese tree taxonomy "), Parthenocissus tricuspidata.For stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae).Acid, flat.1. " detailed outline ": " acid, flat, nontoxic." 2. " Guangdong Chinese medicine " II: " is lightly seasoned, micro-cool." 3. " Fujian Chinese herbal medicine ": " is bitter, flat." [function cures mainly] dispels the wind, and dampness removing is invigorated blood circulation, removing toxic substances.Control phoenix pain of dampness syndrome, dysentery, gonorrhea, traumatic injury, carbuncle furuncle.

Fructus Rhodomyrti: another name Rhodomyrtus tomentosa (Ait.) Hassk., mountain are harvested, Duo Lian, when Radix pyri, mountain dawn are young, harvest subtree, bean is harvested.Myrtle Fructus Rhodomyrti, is used as medicine with root, leaf and fruit.Autumn uproots, and cleans, and section, dries.Sweet, puckery, flat.[function cures mainly] root: dispelling, collateral-activating, astringing to arrest diarrhea.For acute and chronic gastroenteritis, stomachache, dyspepsia, hepatitis, dysentery, rheumatic arthritis, lumbar muscle strain, dysfunctional uterine hemorrhage, proctoptosis; Burn and scald is controlled in external.Leaf: astringing to arrest diarrhea, hemostasis.For acute gastroenteritis, dyspepsia, dysentery: traumatic hemorrhage is controlled in external.Really: enrich blood, nourish, antiabortive.For anemia, body is empty after being ill, neurasthenia, tinnitus, seminal emission.The present invention's root.

Rhizoma Amorphophalli virosi: another name Rhizoma Amorphophalli virosi, Rhizoma Arisaematis head, southern taro.Medical material Ji Yuan: be the tuber of aroid wart handle mill taro.Acrid in the mouth; Sweet; Slightly warm in nature.[function cures mainly] soothing liver and strengthening spleen; Detoxicating and resolving stagnation of pathogens.Main chronic persistent hepatitis.

Rhizoma Bergeniae scopulosae: another name stone Chinese cabbage, Rhizoma Bergeniae scopulosae.For the rhizome of saxifragaceae plant Qinling Mountains Rhizoma Seu Herba Bergeniae.The micro-hardship of puckery, property is put down.Spleen reinforcing stomach invigorating, the solid intestinal of astringent therapy, eliminating dampness and promoting diuresis, invigorates blood circulation.Treating acute and chronic gastroenteritis, edema, metrorrhagia, leucorrhea, stranguria, dysentery, impetigo, tinea alba, scabies.

Polyalthia nemoralis A. D C.: call Lingshui Polyalthia suberosa (Roxb.) Thw, fall bank potato.Annonaceae Polyalthia nemoralis A. D C., is used as medicine with root.Sweet, flat.[function cures mainly] spleen reinforcing stomach invigorating, tonifying the kidney to consolidate the essence.Cure mainly chronic gastritis, inappetence, myasthenia of limbs, seminal emission.Invigorating spleen and reinforcing stomach, tonifying the kidney to consolidate the essence.Control chronic gastritis, taste lose, inappetence, myasthenia of limbs, seminal emission.

Herba Centellae: another name collapses jorum, Herba Calthae Membranaceae, Gotu Kola, Carnis Arca inflata shell grass, Hydrocotyle vulgaris L., Herba sambuci chinensis.This product is the dry herb of samphire Herba Centellae.Bitter, acrid, cold.Return liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.

Rhizoma Menispermi: another name Canis familiaris L. Radix vitis viniferae, grinding stone Radix Sophorae Tonkinensis (" Jilin Chinese medicine handbook "), mountain flower daughter root, light light blade root (" Shandong Chinese medicine ").For the rhizome of menispermaceous plants Caulis menispermi.1. " Traditional Chinese Medicine in Sichuan will ": " bitter in the mouth is pungent, cold in nature, nontoxic." 2. " Zhejiang conventional medical herbs among the people ": " is bitter, cold." [function cures mainly] expelling wind and clearing away heat, regulating QI to expel dampness.Treating tonsillitis, pharyngolaryngitis, rheumatic arthralgia, numbness, edema, beriberi, dysentery enteritis, stomachache abdominal distention." Traditional Chinese Medicine in Sichuan will ": " dehumidifying is dispeled the wind, promoting the circulation of QI to induce diuresis.Control bladder edema, swelling due to wind, beriberi damp-edema, Fengshi Guanjie pain."

Herba artemisiae lactiflorae: another name four seasons dish, natural pearls dish, Cornmarigold, pulmonary tuberculosis grass, duck foot dish, Radix Betae, Herba Artemisiae Anomalae [Guangxi].[source] Compositae mugwort Artemisia lactiflora Wall., with all herbal medicine.Sweet, micro-hardship, flat.[function cures mainly] regulates the flow of vital energy, and invigorates blood circulation, regulating menstruation, dampness removing, removing toxic substances, detumescence.For menoxenia, amenorrhea, chronic hepatitis, liver cirrhosis, oedema due to nephritis, leucorrhea, urticaria, abdominal distention, hernia; Traumatic injury is controlled in external, traumatic hemorrhage, burn and scald, skin infection, eczema.

Herba Pogostemonis: another name herba agastachis rugosae, cat handle, blue or green stem Herba Menthae, Lysimachia capillipes Hemsl, great Ye Herba Menthae, green lotus lotus, river Herba Pogostemonis, revive Herba Pogostemonis, Herba microtoenae insuavis, cat tail perfume, cat Ba Hu, draw perfume (or spice), eight Artemisias, with sweet and sour flavor, Herba Stachydis Japonicae, Herba Pileae Notatae (Herba Oreocnides frutescentis).Medical material Ji Yuan: be the aerial parts of labiate Herba Pogostemonis.Acrid in the mouth; Slightly warm in nature.Return lung; Spleen; Stomach warp.Dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach.Main summertime flu; Cold and heat are had a headache; Breast gastral cavity painful abdominal mass is vexed; Vomiting is had loose bowels; Vomiting during pregnancy; Nasal sinusitis; Hands; Tinea pedis.

Herba Polygalae Japonicae: another name cinnabar grass, JINSUOSHI, Semen Benincasae grass, extension rice grass, polygala japonica houtt., Herba Polygalae Telephioidis.For the herb of Polygalaceae polygala Herba Polygalae Japonicae or ovum leaf Radix Polygalae.Micro-pungent, tepor.[function cures mainly] promoting blood circulation to remove blood stasis, eliminating phlegm and relieving cough, removing toxic substances pain relieving.For pharyngitis, tonsillitis, stomatitis, cough, infantile pneumonia, infantile malnutrition, urinary system calculus, mastitis, osteomyelitis; Venom is controlled in external, furuncle furuncle and phyma.

Herba Veronicastri Sibirici: another name Leptandra sibirica (Li Chenghu " medicobotany "), Herba lysimachiae, veronica, mountain whip grass, Herba Veronicastri Sibirici (" Liaoning economic plants will ").[source] is the herb of goatweed Veronica sibirica.》。" mildly bitter flavor, cold in nature." [function cures mainly] cures cold, rheumatic waist leg muscle pain, and cystitis, insect bite is hindered.1. " Chinese herbal medicine handbook is commonly used in northeast ": " heat-clearing and toxic substances removing." 2. " the conventional Chinese herbal medicine handbook in the north ": " expelling wind and removing dampness, removing toxic substances pain relieving.Treating rheumatic lumbago and skelalgia, myalgia, flu, cystitis, pulmonary tuberculosis, wound hemorrhage, venom, poisonous insect Eriocheir sinensis hinders."

Semen Brassicae Rapae: another name turnip seed (" prescriptions worth thousand gold ").[source] is the seed of crucifer Radix Brassicae rapae.Pungent; Bitter; Cold.Return liver; Spleen; Lung; Large intestine channel.[function cures mainly] nourishing the liver to improve visual acuity; Promoting the circulation of QI to induce diuresis; Heat-clearing and toxic substances removing.Main optic atrohic blindness; Order is dark; Jaundice constipation; Dysuria; Disease is amassed; Skin ulcer cellulitis.

Radix Glycyrrhizae: nature and flavor are sweet, flat; Return spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances "." property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 granule of the present invention

Get Radix Campylotropis Hirtella (Herba Myrsines Africanae) 16g, Rhizoma Corydalis Decumbentis 20g, Radix aconiti szechenyiani 3g, Herba Hedyotidis Diffusae 28g, Herba Clinopodii Polycephali 13g, Herba Syneilesis Aconitifoliae 5g, Herba Aristolochiae Mollissimae 15g, Cortex cercis chinensis 5g, Herba Sarcandrae 9g, enrich blood potato 31g, trailing plants Mi 20g, Semen Cassiae Occidemtalis 4g, Radix Angelicae Sinensis 32g, Tinea Anoplophorae seu Aprionae 14g, Fructus paliuri ramosissimi 27g, Hygrophila salicifolia 19g, Herba stellariae mediae 25g, Radix Pyracanthae Fortuneanae 14g, Caulis fici pumilae (Fructus Fici Pumilae) 23g, Fructus Rhodomyrti 13g, Rhizoma Amorphophalli virosi 23g, Rhizoma Bergeniae scopulosae 15g, Polyalthia nemoralis A. D C. 12g, Herba Centellae 21g, Rhizoma Menispermi 13g, Herba artemisiae lactiflorae 24g, Herba Pogostemonis 18g, Herba Polygalae Japonicae 17g, Herba Veronicastri Sibirici 13g, Semen Brassicae Rapae 24g and Radix Glycyrrhizae 12g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 7 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 2 capsule of the present invention

Get Radix Campylotropis Hirtella (Herba Myrsines Africanae) 23g, Rhizoma Corydalis Decumbentis 17g, Radix aconiti szechenyiani 2g, Herba Hedyotidis Diffusae 22g, Herba Clinopodii Polycephali 17g, Herba Syneilesis Aconitifoliae 6g, Herba Aristolochiae Mollissimae 11g, Cortex cercis chinensis 4g, Herba Sarcandrae 10g, enrich blood potato 26g, Herba seu radix metaplexis 24g, Semen Cassiae Occidemtalis 5g, Radix Angelicae Sinensis 37g, Tinea Anoplophorae seu Aprionae 16g, Fructus paliuri ramosissimi 24g, Hygrophila salicifolia 21g, Herba stellariae mediae 23g, Radix Pyracanthae Fortuneanae 12g, Caulis fici pumilae (Fructus Fici Pumilae) 18g, Fructus Rhodomyrti 16g, Rhizoma Amorphophalli virosi 11g, Rhizoma Bergeniae scopulosae 13g, Polyalthia nemoralis A. D C. 14g, Herba Centellae 18g, Rhizoma Menispermi 18g, Herba artemisiae lactiflorae 23g, Herba Pogostemonis 26g, Herba Polygalae Japonicae 21g, Herba Veronicastri Sibirici 16g, Semen Brassicae Rapae 22g and Radix Glycyrrhizae 13g.

Its preparation method comprises the following steps:

The first step: Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani and Herba Hedyotidis Diffusae are mixed in described ratio, add the water extraction volatile oil relative to 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3, stir 60 minutes, temperature 40 DEG C, obtains volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15;

Second step: Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae, potato of enriching blood, Herba seu radix metaplexis, Semen Cassiae Occidemtalis and Radix Angelicae Sinensis are mixed in described ratio, add relative to mixture 5 times amount determining alcohol be 90% alcohol reflux 4 times, each 2 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;

3rd step: will remain described raw medicinal material and mix in described ratio, adds relative to mixture 8 times of water gagings, boils 7 hours, filters, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.30;

4th step: mixed by the clear paste of the first step, second step, the 3rd step, 70 DEG C of reduced vacuum dryings, get dry extract powder;

5th step: dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 6 weight portion carboxymethyl starch sodium, 40 weight starch mix homogeneously, adding 200 weight portion determining alcohols is 90% alcohol granulation, drying, granulate, adds the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 4 weight portion magnesium stearate, then load in gelatine capsule.

Embodiment 3 oral liquid of the present invention

Get Radix Campylotropis Hirtella (Herba Myrsines Africanae) 19g, Rhizoma Corydalis Decumbentis 11g, Radix aconiti szechenyiani 4g, Herba Hedyotidis Diffusae 35g, Herba Clinopodii Polycephali 22g, Herba Syneilesis Aconitifoliae 4g, Herba Aristolochiae Mollissimae 24g, Cortex cercis chinensis 3g, Herba Sarcandrae 7g, enrich blood potato 19g, Herba seu radix metaplexis 15g, Semen Cassiae Occidemtalis 6g, Radix Angelicae Sinensis 29g, Tinea Anoplophorae seu Aprionae 12g, Fructus paliuri ramosissimi 26g, Hygrophila salicifolia 15g, Herba stellariae mediae 22g, Radix Pyracanthae Fortuneanae 22g, Caulis fici pumilae (Fructus Fici Pumilae) 14g, Fructus Rhodomyrti 15g, Rhizoma Amorphophalli virosi 15g, Rhizoma Bergeniae scopulosae 14g, Polyalthia nemoralis A. D C. 16g, Herba Centellae 20g, Rhizoma Menispermi 16g, Herba artemisiae lactiflorae 21g, Herba Pogostemonis 23g, Herba Polygalae Japonicae 15g, Herba Veronicastri Sibirici 20g, Semen Brassicae Rapae 17g and Radix Glycyrrhizae 18g.

Its preparation method comprises the following steps:

The first step, Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani and Herba Hedyotidis Diffusae are mixed in proportion to obtain mixture one, be that the methanol of 75% is as solvent with determining alcohol, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 4 times of mixture one quality;

Second step, is mixed in proportion Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae, potato of enriching blood, Herba seu radix metaplexis, Semen Cassiae Occidemtalis and Radix Angelicae Sinensis, is ground into powder;

3rd step, adds the distilled water of the powder quality 3 times obtained relative to second step, decocts 2 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 4 times, decoct 1 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 3/4 volume, add the ethanol that determining alcohol is 95%, make determining alcohol reach 80%, leave standstill 20 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 4 times amount, the sucrose of 0.3 times, the sodium benzoate of 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Toxicity test:

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 30, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 28.7g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50 of the present invention > 28.7g crude drug/kg, every day, maximum dosage-feeding was 57.4g crude drug/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore the granule acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.

Long term toxicity test: the capsule of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 3 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Case selection: select patient 132 example meeting Occupational chronic lead poisoning diagnostic criteria, wherein man 108 example, female 24 example.25 ~ 62 years old age, average 38 years old.Be divided into four groups at random, between four groups, age, the course of disease etc. are without difference, have comparability:

Granules in Treating group: 33 people, male 27 people, female 6 people.

Capsule treatment group: 33 people, male 27 people, female 6 people.

Oral liquid treatment group: 33 people, male 27 people, female 6 people.

Matched group: 33 people, male 27 people, female 6 people.

Diagnostic criteria:

Carry out diagnosing and classification according to " diagnostic criteria in occupational chronic lead poisoning " GBZ37-2002.

1, calomel poisoning

Blood lead >=2.9 μm ol/L (0.6mg/L, 600 μ g/L) or lead in urine >=0.58 μm ol/L (0.12mg/L, 120 μ g/L); And there is a following shower, diagnosable is calomel poisoning:

A) 6-amino-r-ketoglutaric >=61.0 μm ol/L (8mg/L, 8000 μ g/L) is urinated;

B) erythrocyte dissociates protoporphyrin (EP) >=3.56 μm ol/L (2mg/L, 2000 μ g/L);

C) he matocrit (ZPP) >=2.91 μm ol/L (13.0 μ g/gHb).

D) symptom such as abdominal part dull pain, abdominal distention, constipation is had.

Diagnostic drives lead test, and lead in urine >=3.86 μm ol/L (0.8mg/L, 800 μ g/L) or 4.82 μm of ol/24h (1mg/24h, 1000 μ g/24h) persons, diagnosable is slight lead poisoning.

2, moderate intoxication

On the basis of calomel poisoning, there is a following shower:

A) angina abdominis;

B) anemia;

C) calomel poisoning peripheral neuropathy.

3, severe intoxication

There is a following shower:

A) plumbous paralysis;

B) toxic encephalopthy;

Qi stagnation and blood stasis type diagnostic criteria: have a headache with the fluctuation of feelings will and change.Have a headache and prolongedly not heal, sore spot is fixing, and as acupuncture, often with stomachache, pain spot is fixed, and tenderness, purplish tongue, pulse condition band is puckery.

Therapeutic Method:

Granules in Treating group: take granule prepared by the embodiment of the present invention 1, three times on the one, one time 2 bag 7 days is a course for the treatment of.

Capsule treatment group: take the embodiment of the present invention 2 prepare capsule, three times on the one, one time 4, within 7 days, be a course for the treatment of.

Oral liquid treatment group: take oral liquid prepared by the embodiment of the present invention 3, three times on the one, a 10ml 7 days is a course for the treatment of.

Matched group: add 5% Glucose Liquid 500ml intravenous drip with calcium disodium chelate (CaNa2-EDTA) 1.0g, 1 time/d, be used in conjunction 3d, stopping 4d is 1 course of therapy.As after 5 courses for the treatment of, PbB or PbU still reaches object of observation diagnostic criteria, then check after 3 months, again drive plumbous treatment if desired.

Outcome measure:

Cure: clinical symptoms, Signs disappear, blood lead, lead in urine recover normal, and other lab testings are normal.

Take a turn for the better: clinical symptoms, Signs disappear substantially, and blood lead, lead in urine inspection and other lab testings are clearly better.

Do not heal: clinical symptoms, Signs are unchanged, blood lead, lead in urine inspection and other lab testings are unchanged.

Therapeutic outcome:

See table 1-3, as can be seen from Table 1 and Table 2, adopt Drug therapy qi stagnation and blood stasis type occupational chronic lead poisoning of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 3, adopt Drug therapy qi stagnation and blood stasis type occupational chronic lead poisoning of the present invention, relative to matched group, treatment time significantly shortens.

After table 1 Four composition did not treat for 1 course for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Cure	Take a turn for the better	Do not heal	Total effective rate
						Granules in Treating group	33	7	26	0	100％
Capsule treatment group	33	9	24	0	100％
						Oral liquid treatment group	33	8	25	0	100％
Matched group	33	3	23	7	78.8％

After table 2 Four composition did not treat for 2 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Cure	Take a turn for the better	Do not heal	Total effective rate
						Granules in Treating group	33	29	4	0	100％
Capsule treatment group	33	30	3	0	100％
						Oral liquid treatment group	33	28	5	0	100％
Matched group	33	20	7	6	81.8％

Four groups, table 3 is cured the case time used and is compared after treating two courses for the treatment of

Group	Number of cases	Average cure time sky
			Granules in Treating group	29	9±3
Capsule treatment group	30	8.7±2
			Oral liquid treatment group	28	10.8±4
Matched group	20	12.5±5

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

Model case: Chen, plumbous smeltery workman, man 35 years old, has a headache and prolongedly not to heal, and sore spot is fixing as acupuncture, normal with stomachache, pain spot is fixed, and touches a tender spot, purplish tongue, pulse condition band is puckery, doubtful occupational chronic lead poisoning, being diagnosed as occupational chronic lead poisoning through checking after being in hospital, giving the granule of the embodiment of the present invention 1 after making a definite diagnosis, every day three times, each 2 bags, after 3 days, symptom is obviously alleviated, and after 7 days, clinical symptoms, Signs disappear, blood lead, lead in urine recover normal, and other lab testings are normally cured and left hospital.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of qi stagnation and blood stasis type occupational chronic lead poisoning, it is characterized in that, comprise following raw medicinal material: Radix Campylotropis Hirtella (Herba Myrsines Africanae), Rhizoma Corydalis Decumbentis, Radix aconiti szechenyiani, Herba Hedyotidis Diffusae, Herba Clinopodii Polycephali, Herba Syneilesis Aconitifoliae, Herba Aristolochiae Mollissimae, Cortex cercis chinensis, Herba Sarcandrae, potato of enriching blood, Herba seu radix metaplexis, Semen Cassiae Occidemtalis, Radix Angelicae Sinensis, Tinea Anoplophorae seu Aprionae, Fructus paliuri ramosissimi, Hygrophila salicifolia, Herba stellariae mediae, Radix Pyracanthae Fortuneanae, Caulis fici pumilae (Fructus Fici Pumilae), Fructus Rhodomyrti, Rhizoma Amorphophalli virosi, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C., Herba Centellae, Rhizoma Menispermi, Herba artemisiae lactiflorae, Herba Pogostemonis, Herba Polygalae Japonicae, Herba Veronicastri Sibirici, Semen Brassicae Rapae and Radix Glycyrrhizae.

2. medicine according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 15-25 part, Rhizoma Corydalis Decumbentis 10-22 part, Radix aconiti szechenyiani 2-5 part, Herba Hedyotidis Diffusae 20-38 part, Herba Clinopodii Polycephali 12-24 part, Herba Syneilesis Aconitifoliae 3-7 part, Herba Aristolochiae Mollissimae 10-25 part, Cortex cercis chinensis 2-6 part, Herba Sarcandrae 6-12 part, to enrich blood potato 18-33 part, Herba seu radix metaplexis 13-27 part, Semen Cassiae Occidemtalis 4-7 part, Radix Angelicae Sinensis 28-40 part, Tinea Anoplophorae seu Aprionae 10-18 part, Fructus paliuri ramosissimi 22-29 part, Hygrophila salicifolia 14-22 part, Herba stellariae mediae 19-27 part, Radix Pyracanthae Fortuneanae 10-25 part, Caulis fici pumilae (Fructus Fici Pumilae) 12-25 part, Fructus Rhodomyrti 12-18 part, Rhizoma Amorphophalli virosi 10-25 part, Rhizoma Bergeniae scopulosae 12-17 part, Polyalthia nemoralis A. D C. 10-18 part, Herba Centellae 16-24 part, Rhizoma Menispermi 10-20 part, Herba artemisiae lactiflorae 21-26 part, Herba Pogostemonis 16-30 part, Herba Polygalae Japonicae 13-23 part, Herba Veronicastri Sibirici 12-22 part, Semen Brassicae Rapae 16-25 part and Radix Glycyrrhizae 11-19 part.

3. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 16-23 part, Rhizoma Corydalis Decumbentis 11-20 part, Radix aconiti szechenyiani 2-4 part, Herba Hedyotidis Diffusae 22-35 part, Herba Clinopodii Polycephali 13-22 part, Herba Syneilesis Aconitifoliae 4-6 part, Herba Aristolochiae Mollissimae 11-24 part, Cortex cercis chinensis 3-5 part, Herba Sarcandrae 7-10 part, to enrich blood potato 19-31 part, Herba seu radix metaplexis 15-24 part, Semen Cassiae Occidemtalis 4-6 part, Radix Angelicae Sinensis 29-37 part, Tinea Anoplophorae seu Aprionae 12-16 part, Fructus paliuri ramosissimi 24-27 part, Hygrophila salicifolia 15-21 part, Herba stellariae mediae 20-25 part, Radix Pyracanthae Fortuneanae 12-22 part, Caulis fici pumilae (Fructus Fici Pumilae) 14-23 part, Fructus Rhodomyrti 13-16 part, Rhizoma Amorphophalli virosi 11-23 part, Rhizoma Bergeniae scopulosae 13-15 part, Polyalthia nemoralis A. D C. 12-16 part, Herba Centellae 18-21 part, Rhizoma Menispermi 13-18 part, Herba artemisiae lactiflorae 21-24 part, Herba Pogostemonis 18-26 part, Herba Polygalae Japonicae 15-21 part, Herba Veronicastri Sibirici 13-20 part, Semen Brassicae Rapae 17-24 part and Radix Glycyrrhizae 12-18 part.

4. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 16 parts, Rhizoma Corydalis Decumbentis 20 parts, Radix aconiti szechenyiani 3 parts, Herba Hedyotidis Diffusae 28 parts, Herba Clinopodii Polycephali 13 parts, Herba Syneilesis Aconitifoliae 5 parts, Herba Aristolochiae Mollissimae 15 parts, Cortex cercis chinensis 5 parts, Herba Sarcandrae 9 parts, to enrich blood potato 31 parts, Herba seu radix metaplexis 20 parts, Semen Cassiae Occidemtalis 4 parts, Radix Angelicae Sinensis 32 parts, Tinea Anoplophorae seu Aprionae 14 parts, Fructus paliuri ramosissimi 27 parts, Hygrophila salicifolia 19 parts, Herba stellariae mediae 25 parts, Radix Pyracanthae Fortuneanae 14 parts, Caulis fici pumilae (Fructus Fici Pumilae) 23 parts, Fructus Rhodomyrti 13 parts, Rhizoma Amorphophalli virosi 23 parts, 15 parts, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C. 12 parts, Herba Centellae 21 parts, Rhizoma Menispermi 13 parts, Herba artemisiae lactiflorae 24 parts, Herba Pogostemonis 18 parts, Herba Polygalae Japonicae 17 parts, Herba Veronicastri Sibirici 13 parts, Semen Brassicae Rapae 24 parts and 12 parts, Radix Glycyrrhizae.

5. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 23 parts, Rhizoma Corydalis Decumbentis 17 parts, Radix aconiti szechenyiani 2 parts, Herba Hedyotidis Diffusae 22 parts, Herba Clinopodii Polycephali 17 parts, Herba Syneilesis Aconitifoliae 6 parts, Herba Aristolochiae Mollissimae 11 parts, Cortex cercis chinensis 4 parts, Herba Sarcandrae 10 parts, to enrich blood potato 26 parts, Herba seu radix metaplexis 24 parts, Semen Cassiae Occidemtalis 5 parts, Radix Angelicae Sinensis 37 parts, Tinea Anoplophorae seu Aprionae 16 parts, Fructus paliuri ramosissimi 24 parts, Hygrophila salicifolia 21 parts, Herba stellariae mediae 23 parts, Radix Pyracanthae Fortuneanae 12 parts, Caulis fici pumilae (Fructus Fici Pumilae) 18 parts, Fructus Rhodomyrti 16 parts, Rhizoma Amorphophalli virosi 11 parts, 13 parts, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C. 14 parts, Herba Centellae 18 parts, Rhizoma Menispermi 18 parts, Herba artemisiae lactiflorae 23 parts, Herba Pogostemonis 26 parts, Herba Polygalae Japonicae 21 parts, Herba Veronicastri Sibirici 16 parts, Semen Brassicae Rapae 22 parts and 13 parts, Radix Glycyrrhizae.

6. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Campylotropis Hirtella (Herba Myrsines Africanae) 19 parts, Rhizoma Corydalis Decumbentis 11 parts, Radix aconiti szechenyiani 4 parts, Herba Hedyotidis Diffusae 35 parts, Herba Clinopodii Polycephali 22 parts, Herba Syneilesis Aconitifoliae 4 parts, Herba Aristolochiae Mollissimae 24 parts, Cortex cercis chinensis 3 parts, Herba Sarcandrae 7 parts, to enrich blood potato 19 parts, Herba seu radix metaplexis 15 parts, Semen Cassiae Occidemtalis 6 parts, Radix Angelicae Sinensis 29 parts, Tinea Anoplophorae seu Aprionae 12 parts, Fructus paliuri ramosissimi 26 parts, Hygrophila salicifolia 15 parts, Herba stellariae mediae 22 parts, Radix Pyracanthae Fortuneanae 22 parts, Caulis fici pumilae (Fructus Fici Pumilae) 14 parts, Fructus Rhodomyrti 15 parts, Rhizoma Amorphophalli virosi 15 parts, 14 parts, Rhizoma Bergeniae scopulosae, Polyalthia nemoralis A. D C. 16 parts, Herba Centellae 20 parts, Rhizoma Menispermi 16 parts, Herba artemisiae lactiflorae 21 parts, Herba Pogostemonis 23 parts, Herba Polygalae Japonicae 15 parts, Herba Veronicastri Sibirici 20 parts, Semen Brassicae Rapae 17 parts and 18 parts, Radix Glycyrrhizae.

7., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

8., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

9., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps: