CN105106775A - Traditional Chinese medicine preparation for treating puerperal constipation and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating puerperal constipation and a preparation method thereof. The traditional Chinese medicine preparation is prepared from swimming bladders, corn cervi pantotrichum, smilax china, long stephania herbs, ox galls, lignum dalbergiae odoriferae, ludwigia octovalvis, tamarind fruits, pericarpium trichosanthis, clematis florida, paraphlonia, rheum forrestii diels, mirabilitum, malva sinensis, neocheiropteris palmatopedata, abutilon indicum seeds, aleurites moluccana seeds, caulis sargentodoxae, wedelia wallichii less and shrubberry rhodiola roots. The prepared traditional Chinese medicine preparation for treating the puerperal constipation has the advantages of being convenient to administrate, free of pain, free of toxic and side effects, rapid to achieve effects and simple in preparation technology.

Description

A kind of Chinese medicine preparation for the treatment of difficulty in defecation after delivery and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation for the treatment of difficulty in defecation after delivery and preparation method thereof.

Background technology

Difficulty in defecation after delivery is obstetrics' clinical obstetrics common diseases, and defecate puerperal is not understood a few days, or it is involved and abstruse to defecate, and dry pain person time just, claim " difficulty in defecation after delivery ", the traditional Chinese medical science is called " puerperal constipation ".Primary disease is many loses blood because puerperal gives a birth, and nutrition is poly-empty, body fluid loss, and can not make moist intestinal; Or hyperactivity of fire caused by deficiency of YIN, interior bright body fluid, intestinal loses in moistening, and it is unfavorable to conduct; Or the ferritic deficiency of vital energy, consumption gas time again because producing, large anenterneuria transmission; Or puerperal dyspepsia, heat accumulating in the intestines, caused by FU QI being obstructed.The general diet of primary disease is as usual, and see without disease companions such as stomachache, vomitings, the constipation caused with other diseases is different.

Difficulty in defecation after delivery, namely on the books as far back as " Medical Treasures of the Golden Chamber married woman abnormal pulse in puerperal is demonstrate,proved and controls ".Married woman loses blood owing to giving a birth new puerperal, and nutrient blood is suddenly empty, body fluid loss, and can not make moist intestinal, so that dryness of the intestine dyschezia, or deficiency of YIN fire is contained, interior bright body fluid, and thanks to, intestinal loses in making moist the few liquid in Tianjin, and it is unfavorable to conduct, then condensation of defecating.The sick position of primary disease is at large intestine." Shengji Zonglu ": " large intestine person, the organ in charge of transportation, change page-out, body fluid loss in puerperal, uninteresting in stomach, profit is supported not enough, and waste matter is stopped up stagnant, therefore difficulty in defecation or obstructed, the people of all new products, moring sickness this also, many by dehematizing, interior depletion of body fluid thus also ".The cause of disease is at blood deficiency and depleted fluid in puerperal, therefore in treatment, should have thin fluid injury according to puerpera, blood-stasis internal-depression, the pathological characteristic of multiple deficiency and stasis, with nourshing blood and promoting blood circulation, nourshing Yin and drynsessmoistening prescription is main, must guard against bitter cold catharsis, causes logical and rushes down and can not stop, or further difficult logical, injures middle friendship vigour.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of novel use safety, has no side effect, treatment cycle is short, instant effect, Chinese medicine preparation of effective treatment difficulty in defecation after delivery and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of difficulty in defecation after delivery, described Chinese medicine preparation comprises following raw medicinal material: Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae, Ludwigia octovalvis (Jacq.) Raven, Fructus Tamarindi Indicae, the fruit-rind of Chinese trichosanthes, Radix clematidis floridae, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, red oxtail seven, Mirabilitum, Radix Malvae sylvestris, Neocheiropteris palmatopedata(Bak.) Christ, Semen abutili indici, Semen Aleuritis Moluccanae, Caulis Sargentodoxae, enrich blood potato and Radix Rhodiolae Dumulosae.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: 10 ~ 25 parts, Air Bladder pseudosciaenae seu Acipenser, 15 ~ 25 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 10 ~ 30 parts, Herba Stephaniae Longae 10 ~ 25 parts, Fel Bovis seu Bubali 10 ~ 25 parts, Lignum Dalbergiae Odoriferae 15 ~ 30 parts, Ludwigia octovalvis (Jacq.) Raven 10 ~ 25 parts, Fructus Tamarindi Indicae 10 ~ 30 parts, the fruit-rind of Chinese trichosanthes 20 ~ 35 parts, Radix clematidis floridae 10 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 15 ~ 30 parts, red oxtail 7 10 ~ 30 parts, Mirabilitum 10 ~ 25 parts, Radix Malvae sylvestris 10 ~ 25 parts, Neocheiropteris palmatopedata(Bak.) Christ 10 ~ 20 parts, Semen abutili indici 10 ~ 30 parts, Semen Aleuritis Moluccanae 10 ~ 30 parts, Caulis Sargentodoxae 10 ~ 20 parts, to enrich blood potato 15 ~ 25 parts and Radix Rhodiolae Dumulosae 10 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: 10 ~ 15 parts, Air Bladder pseudosciaenae seu Acipenser, 20 ~ 25 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 15 ~ 25 parts, Herba Stephaniae Longae 15 ~ 25 parts, Fel Bovis seu Bubali 15 ~ 20 parts, Lignum Dalbergiae Odoriferae 20 ~ 25 parts, Ludwigia octovalvis (Jacq.) Raven 15 ~ 20 parts, Fructus Tamarindi Indicae 20 ~ 30 parts, the fruit-rind of Chinese trichosanthes 25 ~ 35 parts, Radix clematidis floridae 10 ~ 15 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20 ~ 30 parts, red oxtail 7 15 ~ 25 parts, Mirabilitum 10 ~ 15 parts, Radix Malvae sylvestris 15 ~ 20 parts, Neocheiropteris palmatopedata(Bak.) Christ 15 ~ 20 parts, Semen abutili indici 20 ~ 30 parts, Semen Aleuritis Moluccanae 15 ~ 25 parts, Caulis Sargentodoxae 15 ~ 20 parts, to enrich blood potato 20 ~ 25 parts and Radix Rhodiolae Dumulosae 15 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: 13 parts, Air Bladder pseudosciaenae seu Acipenser, 23 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 20 parts, Herba Stephaniae Longae 21 parts, Fel Bovis seu Bubali 18 parts, Lignum Dalbergiae Odoriferae 22 parts, Ludwigia octovalvis (Jacq.) Raven 18 parts, Fructus Tamarindi Indicae 25 parts, the fruit-rind of Chinese trichosanthes 26 parts, Radix clematidis floridae 15 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 25 parts, red oxtail 7 23 parts, Mirabilitum 13 parts, Radix Malvae sylvestris 18 parts, Neocheiropteris palmatopedata(Bak.) Christ 16 parts, Semen abutili indici 25 parts, Semen Aleuritis Moluccanae 20 parts, Caulis Sargentodoxae 15 parts, enrich blood potato 22 parts and Radix Rhodiolae Dumulosae 20 parts.

When the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae and Ludwigia octovalvis (Jacq.) Raven are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix clematidis floridae, red oxtail seven, Mirabilitum, Radix Malvae sylvestris and Semen abutili indici are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

Beneficial effect of the present invention: the Chinese medicine preparation that difficulty in defecation after delivery of the present invention uses is easy to use, no pain, have no side effect, instant effect, and preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of difficulty in defecation after delivery, Chinese medicine preparation comprises following raw medicinal material: Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae, Ludwigia octovalvis (Jacq.) Raven, Fructus Tamarindi Indicae, the fruit-rind of Chinese trichosanthes, Radix clematidis floridae, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, red oxtail seven, Mirabilitum, Radix Malvae sylvestris, Neocheiropteris palmatopedata(Bak.) Christ, Semen abutili indici, Semen Aleuritis Moluccanae, Caulis Sargentodoxae, enrich blood potato and Radix Rhodiolae Dumulosae.

The pharmacology of various raw medicinal material is as follows:

Air Bladder pseudosciaenae seu Acipenser: [source] medical material Ji Yuan: be the Air Bladder pseudosciaenae seu Acipenser of Sciaenidae animal Carnis Pseudosciaenae, Carnis Pseudosciaenae, Nibea albiflora or Acipenseridae animal mandarin sturgeon, sturgeon etc.[nature and flavor] sweet in the mouth; Property is put down; [return through] kidney; Liver Channel.[function cures mainly] invigorating the liver and kidney; Nourishing blood and hemoslasis; Dissipating blood stasis for subsidence of swelling.Main emission due to deficiency of the kidney; Weakness of the waist and knees; Lumbago; Vertigo and tinnitus; Leucorrhea; Habitual abortion; Ischemic spasm; Puerperal puerperal tetanus; Tetanus; Epilepsy; Aplastic anemia; Spit blood; Hematuria; Metrorrhagia; Traumatic hemorrhage; Carbuncle of yin nature; Fistula; Chronic ulcer; Chap; Gout; Hemorrhoid.[each discussion] " herbal classic is met former ": bladder glue closes Semen Astragali Complanati name Dwelling Model, is controlling nocturnal emission with astringent drugs key medicine.Folk prescription grinds to fry simply again, Saccharum Sinensis Roxb. adjust, take a money an ancient type of spoon day, control hemorrhoid the best, prolonged hemorrhoid from withered fall.Ashing, tetany caused by wind pathogen after managing property, tetanus convulsion, gets it and grows flourish passages through which vital energy circulates, and wind syndrome caused by deficiency from breath also." book on Chinese herbal medicine newly organized ": Air Bladder pseudosciaenae seu Acipenser is thick, enter kidney and mend essence, probably property is greasy stagnant, adds Radix Ginseng, and capable of wherein with gas, then essence is more prebiotic, and without cementing fraud also.Compendium of Material Medica: fish glue, only injured blood goes out incessantly; Bladder glue, charred medicinal herb with its property retained, control married woman difficult labour, puerperal tetany caused by wind pathogen, tetanus convulsion, preventing or arresting vomiting blood, dissipating blood stasis blood, detumescence poison." book on Chinese herbal medicine is newly organized ": mend lean blood." book on Chinese herbal medicine asks former ": nourishing muscle and tendon arteries and veins, determines hands war, controlling nocturnal emission with astringent drugs.[extracts] " China's book on Chinese herbal medicine "

Cornu Cervi Pantotrichum: [another name] megalosaurus pearl.[source] medical material Ji Yuan: the young horn that the close raw fine hair of stag for animal in deer family Cervus nippon Temminck, Cervus elaphus linnaeus etc. not yet ossify.[nature and flavor] sweet in the mouth; Salty; Warm in nature; [return through] kidney; Liver Channel.[function cures mainly] invigorating kidney-YANG; Benefiting essence-blood; Bone and muscle strengthening; Holder sore.Main kidney yang deficiency; Sexual impotence spermatorrhea; Cold womb is infertile; Asthenia is won thin; Mental fatigue fear of cold; Dizzy; Hiccough and deaf; Aching pain in waist and back; Muscles and bones flaccidity is soft; Children's's five kinds of growth retardation; Woman's bleeding not during menses; Carbuncle of yin nature.[each discussion] " Bencao Jingshu ": Cornu Cervi Pantotrichum, reports the matter of pure sun, containing the gas of hair growth promoting.Married woman rushes conception vessel void, be then the stagnant blood that leaks down, or blood stasis is at abdomen, or is stranguria caused by urinary stone.Man's deficiency of the liver and kindey is then cold and heat, infantile convulsion, or the voluminous symptoms like malaria of asthenia, or weakness and emaciation, painful limbs, pain along the spinal column, or frequent micturition profit.Let out essence, hematuria.The moon point of the gate of vitality, percardium and liver, kidney walked by this medicine, mend lower first kidney-Yang, therefore can lead as above all cards, and the strong will of QI invigorating also.Carbuncle cellulitis infections, all caused by stagnation of nutrient QI, sweet temperature energy promoting blood circulation, and space between skin and muscles, therefore also lead it." detailed outline ": spermatogenesis mends marrow, Yiyang of nourishing blood, strong muscles and bones.Control all deficient, deaf, order is dark, dizzy, dysentery of deficiency type." book on Chinese herbal medicine highly necessary ": control children's's variola empty white, pulp-water does not fill, or loose stool and diarrhea, and shiver with cold is grited one's teeth; The renal failure of punish-old people spleen is trembled with fear, and the gate of vitality is without fire, or diet often subtracts, the sliding all cards in large loose stool.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Smilacis Chinensis: [source] medical material Ji Yuan: be the rhizome of liliaceous plant Rhizoma Smilacis Chinensis.[nature and flavor] are sweet; Acid; Property is put down; [return through] liver; Kidney channel.[function cures mainly] expelling wind and removing dampness; Removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome; Stranguria with turbid discharge; Leukorrhagia; Have loose bowels; Dysentery; Carbuncle sore tumefacting virus; Stubborn dermatitis; Burn and scald.Not [each discussion] " not Lu ": the cold pain in main back, migratory arthralgia, beneficial vim and vigour, only normal urination.. " detailed outline ": control and quench one's thirst, metrorrhagia, lower profit." book on Chinese herbal medicine is original ": diuresis." medical center bun is wanted ": the hard kidney of slow liver, clear small intestine fire, changes bladder water.Control malignant boil, skin infection, insect poison.[extracts] " China's book on Chinese herbal medicine "

Herba Stephaniae Longae: [source] medical material Ji Yuan: be the root of menispermaceous plants Herba Stephaniae Longae, rhizome or Herb.[nature and flavor] are bitter; Cold; [return through] liver; Gallbladder; Large intestine channel; [function cures mainly] heat-clearing and toxic substances removing; Inducing diuresis and reducing edema; Dispelling, collateral-activating.Main dysentery; Urine leaching is puckery; Edema; Jaundice; Rheumatic arthralgia; Sore throat; Ting ear; Sore and toxic; Venom.[each discussion] " south of the Five Ridges gather medicinal herbs record ": promoting regeneration of the tissue and arresting bleeding.Control dysentery, control jaundice again, go mad.Breast ulcer, and slab sugar mash deposited it." Luchuan book on Chinese herbal medicine ": refreshing and detoxicating, logical stool.Control gastroenteritis, constipation, venom." Nanning City's medicine will ": clearing away heat and promoting diuresis, controls inflammatory diarrhea and hematuria; External application malignant boil, detumescence poison.[extracts] " China's book on Chinese herbal medicine "

Fel Bovis seu Bubali: [source] medical material Ji Yuan: be gallbladder or the bile of bovid cattle or Babalus bubalis L..[nature and flavor] bitter in the mouth; Cold in nature; [return through] liver; Gallbladder; Lung meridian.[function cures mainly] liver heat removing and eyesight improving; Promoting the secretion of bile and dredging bowels; Removing toxic substances and promoting subsidence of swelling.The hot order disease of main air; Trusted subordinate's heat is thirsty; Jaundice; Cough with copious phlegm; Infantile convulsion; Constipation; Carbuncle; Hemorrhoid.Not [each discussion] " not Lu ": except trusted subordinate is hot, thirsty, sharp, mouth restless with anxiety, beneficial order eyeball.Crow Fel Bovis seu Bubali, main improving eyesight, treats infantile malnutrition and wets, to make Chinese scholartree, the more god of clothes." property of medicine opinion ": limacia sagittata master quench one's thirst, sharp large and small intestinal." modern Practical Chinese medicinal ": be the whole intestinal of stomach invigorating, the bitter cathartic of bitter benefit.Control dyspepsia, chronic gastritis, stool chronic constipated, liver and gall jaundice, stomach is swollen full.[extracts] " China's book on Chinese herbal medicine "

Lignum Dalbergiae Odoriferae: [source] medical material Ji Yuan: be trunk or the root heartwood of leguminous plant Lignum Dalbergiae Odoriferae wingceltis, sissoo.[nature and flavor] are pungent; Temperature; Nontoxic; [return through] liver; Spleen; Lung; Heart channel.[function cures mainly] promoting blood circulation to remove blood stasis, hemostasis analgesic therapy, sending down the abnormal ascending QI, wards off dirty.Main pain in chest and hypochondrium, traumatic injury, wound hemorrhage, and the vomiting stomachache of colic of cold type pain or foul internal resistance.[each discussion] " herbal classic is met former ": Lignum Dalbergiae Odoriferae red complexion, enters blood system and decline, therefore for oral administration can promoting the circulation of blood break stagnant, outer painting can be stopped blooding analgesic therapy.Deficiently again tell red, color stasis of blood taste not fresh person should add with it, its merit and Ophicalcitum loose not different." Haiyao Bencao, Oversea Materia Medica ": the capable seasonal epidemic pathogens in main sky." book on Chinese herbal medicine is new again ": control all pathogenic factor in the exterior, the strongly fragrant gas of a surname's the five internal organs, profit three burnt heat in blood, emesis, and taste.[extracts] " China's book on Chinese herbal medicine "

Ludwigia octovalvis (Jacq.) Raven: Dendrobium nobile Lindl, key cylinder, Herba Jussiaeae suffruticosae, syringe grass, water seedling grass, water lamp perfume, water Fructus Musae in [another name] grass, sweep pot grass, grass dragon, false yellow car, false any of several broadleaf plants.[source] medical material Ji Yuan: be the herb of onagraceae plant Herba Ludwigiae Prostratae.Gather and store: aerial parts of gathering in summer, autumn, cleaning, using fresh herb or dry.[nature and flavor] bitter in the mouth; Micro-pungent; Cold in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main cold, fever; Children's's infantile malnutrition with fever; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Hypertension; Edema; Damp-heat dysentery; Drench pain; Nebulousurine; Leukorrhagia; Acute mastitis; Furuncle swelling toxin; Hemorrhoid; Burn and scald; Venom.[extracts] " China's book on Chinese herbal medicine "

Fructus Tamarindi Indicae: [source] medical material Ji Yuan: be the fruit of leguminous plant tamarind.[nature and flavor] sweet acid; Cool; [return through] heart; Stomach warp; [function cures mainly] clearing away summer-heat; Stomach function regulating removing food stagnancy.Main heatstroke; Inappetence; Infantile malnutrition; Vomiting during pregnancy; Constipation.[each discussion] " the southern regions of the Yunnan Province book on Chinese herbal medicine ": controlling alcoholizing is expectorant, every in stomach, with white sugar soft extracts, sooner or later takes a money." choosing of Yunnan Chinese herbal medicine ": clearing away summer-heat, promoting digestion and removing stagnation.[extracts] " China's book on Chinese herbal medicine "

The fruit-rind of Chinese trichosanthes: [source] medical material Ji Yuan: be the peel of cucurbitaceous plant Fructus Trichosanthis and Chinese Fructus Trichosanthis.[nature and flavor] sweet in the mouth; Micro-hardship; Cold in nature; [return through] returns lung; Stomach warp.[function cures mainly] removing heat from the lung and dissipating phlegm; Promoting the circulation of QI relieving stuffiness of the chest by dispersing aggregation of pathogens.Main cough due to lung-heat; Breast side of body painful abdominal mass pain, laryngopharynx swelling and pain; Nodules of the breast breast acute mastitis.[each discussion] " Chinese medicinal herbal ": clearing away phlegm is tied, and soothing liver-QI is strongly fragrant.Control phlegm-heat cough, the breast side of body is had a pain." Traditional Chinese Medicine in Sichuan will ": lung moistening sending down the abnormal ascending QI, eliminating phlegm and stopping cough.Control and have sore throat, constipation due to dry stool and acute mastitis." Guangdong Chinese medicine ": control and tell, be defeated in battle, yearningly dry, pharyngalgia, constipation.[extracts] " China's book on Chinese herbal medicine "

Radix clematidis floridae: [source] medical material Ji Yuan: be Herb or the root of ranunculaceae plant Radix clematidis floridae or polyphyll Radix clematidis floridae.[nature and flavor] bitter in the mouth; Micro-pungent; Warm in nature; [return through] returns liver; Spleen; Kidney channel.[function cures mainly] diuresis; Dredging collateral; Regulating the flow of QI to relieve constipation; Removing toxic substances.Cure mainly rheumatic arthritis; Dysuria; Amenorrhea; Constipation abdominal distention; Acute toothache; Eye plays punctate keratitis; Worm venom; Jaundice.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu: [another name] native nine uncompleted buildings, large pellet in a shotgun cartridge dish, tall bottle with spout flower.[source] medical material Ji Yuan: be root or the herb of the false Herba phlomidis of labiate lobule.Gather and store: summer, autumn gather, cleaning, dry.[nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] is nourshing Yin and drynsessmoistening prescription; Cough-relieving; Regulating menstruation.Main deficiency of YIN chronic cough; Sputum mixed with blood; Menoxenia.[extracts] " China's book on Chinese herbal medicine "

Red oxtail seven: [source] medical material Ji Yuan: be the root of polygonaceae plant oxtail seven.[nature and flavor] are bitter; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Relaxing muscles and tendons to promote blood circulation; Hemostasis.Main laryngopharynx swelling and pain; Mumps; Constipation; Stomachache; Amenorrhea; Dysmenorrhea; Traumatic injury; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Mirabilitum: [source] medical material Ji Yuan: for Sulfates Natrii Sulfas talks about the semifinished product of mineral nitre or artifact Natrii Sulfas.[nature and flavor] are pungent; Bitter salty; Cold; [return through] stomach; Large intestine channel.[function cures mainly] is purged heat and is moisturized; Clearing heat for detumescence; Hard masses softening and resolving.Main excess-heat stagnates; Abdominal distention constipation; Retention of phlegm gathers; Conjunctival congestion and swelling pain; Sore throat; Carbuncle; Swelling of the breast; Swelling and pain of hemorrhoid; Retention of phlegm gathers; Married woman's abdominal pain due to blood stasis.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Malvae sylvestris: [another name] Qiao, ant bloody stasis, Jing Kui, Qian Kui, ancient type of banner hoisted on a featherdecked mast joint flower, little Bai Shuqi flower, refined gas flower, checkerbloom, little SHUJI flower, Flos Solani Melongenae, Folium Malvae, Chinese mallow, wheat straw flower.[source] medical material Ji Yuan: be the flower of Malvaceae plant Radix Malvae sylvestris, leaf and stem.Gather and store: summer, autumn gather, and dry.[nature and flavor] are salty; Cold.[function cures mainly] diuresis relieving constipation; Heat-clearing and toxic substances removing.Main defecation is not smooth; Leukorrhagia; Tuberculous lymphadenitis; Laryngopharynx swelling and pain.[extracts] " China's book on Chinese herbal medicine "

Neocheiropteris palmatopedata(Bak.) Christ: [source] medical material Ji Yuan: be root or the herb of Plants of Polypodiaceae Neocheiropteris palmatopedata(Bak.) Christ.[nature and flavor] are bitter; Acid; Puckery; Cool; [return through] liver; Spleen channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Dyspepsia and intestinal stasis relieving.Main dysuria; Drench the puckery pain of drop; Food stagnation is glutted; Dysentery; Constipation.[extracts] " China's book on Chinese herbal medicine "

Semen abutili indici: [source] medical material Ji Yuan: be the seed of Malvaceae plant Herba abutili indici Abutilonindicum (L.) Sweet.[nature and flavor] are pungent; Sweet; Cold; [return through] liver; Large intestine channel.[function cures mainly] is sensible; Diuretic; Heat reliving and toxin-eliminating.Main deafness; Breast antiperspirant is obstructed; Edema; Constipation; Dysentery; Swollen ulcer drug.[extracts] " China's book on Chinese herbal medicine "

Semen Aleuritis Moluccanae: [another name] extra large Semen Juglandis, black Oleum Verniciae fordii, oil fruit, inspection fruit.[source] medical material Ji Yuan: be the mature seed of euphorbia plant candlenut tree.[nature and flavor] are sweet; Cold; Slightly poisonous; [return through] liver; Spleen channel.[function cures mainly] invigorates blood circulation; Intestine moistening.Main amenorrhea; Dryness of the intestine constipation.[extracts] " China's book on Chinese herbal medicine "

Caulis Sargentodoxae: [source] this product is the dry rattan of plants of Lardizabalaceae Caulis Sargentodoxae.[nature and flavor] are bitter, flat.[return through] returns large intestine, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, invigorates blood circulation, dispels the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.[extracts] " Chinese Pharmacopoeia "

Enrich blood potato: [source] medical material Ji Yuan: be the tuber of Dioscoreaceae plant seven leaf Rhizoma Dioscoreae.[nature and flavor] are pungent; Micro-sweet; Cool.[function cures mainly] removing stasis to stop bleeding; Reducing swelling and alleviating pain.Main impairment of the lung caused by overstrain hemoptysis; Hepatosplenomegaly; Dysmenorrhea; Puerperal abdonimal pain; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Rhodiolae Dumulosae: [source] medical material Ji Yuan: be herb and the root of crassulaceae plants Rhodiola dumulosa.[nature and flavor] sweet in the mouth; Micro-hardship; Property is put down.[return through] kidney; Liver Channel.The nourishing the liver of [function cures mainly] kidney tonifying; Regulating menstruation and activating blood.Main consumptive fever hectic fever due to YIN-deficiency; An emaciation due to blood disorder; Have a dizzy spell; Menoxenia.[extracts] " China's book on Chinese herbal medicine "

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: 10 ~ 25 parts, Air Bladder pseudosciaenae seu Acipenser, 15 ~ 25 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 10 ~ 30 parts, Herba Stephaniae Longae 10 ~ 25 parts, Fel Bovis seu Bubali 10 ~ 25 parts, Lignum Dalbergiae Odoriferae 15 ~ 30 parts, Ludwigia octovalvis (Jacq.) Raven 10 ~ 25 parts, Fructus Tamarindi Indicae 10 ~ 30 parts, the fruit-rind of Chinese trichosanthes 20 ~ 35 parts, Radix clematidis floridae 10 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 15 ~ 30 parts, red oxtail 7 10 ~ 30 parts, Mirabilitum 10 ~ 25 parts, Radix Malvae sylvestris 10 ~ 25 parts, Neocheiropteris palmatopedata(Bak.) Christ 10 ~ 20 parts, Semen abutili indici 10 ~ 30 parts, Semen Aleuritis Moluccanae 10 ~ 30 parts, Caulis Sargentodoxae 10 ~ 20 parts, to enrich blood potato 15 ~ 25 parts and Radix Rhodiolae Dumulosae 10 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: 10 ~ 15 parts, Air Bladder pseudosciaenae seu Acipenser, 20 ~ 25 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 15 ~ 25 parts, Herba Stephaniae Longae 15 ~ 25 parts, Fel Bovis seu Bubali 15 ~ 20 parts, Lignum Dalbergiae Odoriferae 20 ~ 25 parts, Ludwigia octovalvis (Jacq.) Raven 15 ~ 20 parts, Fructus Tamarindi Indicae 20 ~ 30 parts, the fruit-rind of Chinese trichosanthes 25 ~ 35 parts, Radix clematidis floridae 10 ~ 15 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20 ~ 30 parts, red oxtail 7 15 ~ 25 parts, Mirabilitum 10 ~ 15 parts, Radix Malvae sylvestris 15 ~ 20 parts, Neocheiropteris palmatopedata(Bak.) Christ 15 ~ 20 parts, Semen abutili indici 20 ~ 30 parts, Semen Aleuritis Moluccanae 15 ~ 25 parts, Caulis Sargentodoxae 15 ~ 20 parts, to enrich blood potato 20 ~ 25 parts and Radix Rhodiolae Dumulosae 15 ~ 25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: 13 parts, Air Bladder pseudosciaenae seu Acipenser, 23 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 20 parts, Herba Stephaniae Longae 21 parts, Fel Bovis seu Bubali 18 parts, Lignum Dalbergiae Odoriferae 22 parts, Ludwigia octovalvis (Jacq.) Raven 18 parts, Fructus Tamarindi Indicae 25 parts, the fruit-rind of Chinese trichosanthes 26 parts, Radix clematidis floridae 15 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 25 parts, red oxtail 7 23 parts, Mirabilitum 13 parts, Radix Malvae sylvestris 18 parts, Neocheiropteris palmatopedata(Bak.) Christ 16 parts, Semen abutili indici 25 parts, Semen Aleuritis Moluccanae 20 parts, Caulis Sargentodoxae 15 parts, enrich blood potato 22 parts and Radix Rhodiolae Dumulosae 20 parts.

The present invention further provides again a kind of preparation method of Chinese medicine preparation of above-mentioned treatment difficulty in defecation after delivery, and the dosage form of described Chinese medicine preparation is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The present invention further provides again a kind of preparation method of Chinese medicine preparation of above-mentioned treatment difficulty in defecation after delivery, and the dosage form of described Chinese medicine preparation is capsule, and it comprises the following steps:

The first step, Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae and Ludwigia octovalvis (Jacq.) Raven are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix clematidis floridae, red oxtail seven, Mirabilitum, Radix Malvae sylvestris and Semen abutili indici are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: granule prepared by the present invention

Get Air Bladder pseudosciaenae seu Acipenser 130g, Cornu Cervi Pantotrichum 230g, Rhizoma Smilacis Chinensis 200g, Herba Stephaniae Longae 200g, Fel Bovis seu Bubali 180g, Lignum Dalbergiae Odoriferae 220g, Ludwigia octovalvis (Jacq.) Raven 180g, Fructus Tamarindi Indicae 250g, fruit-rind of Chinese trichosanthes 260g, Radix clematidis floridae 150g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 250g, red oxtail seven 230g, Mirabilitum 130g, Radix Malvae sylvestris 180g, Neocheiropteris palmatopedata(Bak.) Christ 160g, Semen abutili indici 250g, Semen Aleuritis Moluccanae 200g, Caulis Sargentodoxae 150g, enrich blood potato 220g and Radix Rhodiolae Dumulosae 200g.

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 85%, be heated to boiling reflux 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.

Embodiment 2: capsule prepared by the present invention

Get Air Bladder pseudosciaenae seu Acipenser 110g, Cornu Cervi Pantotrichum 240g, Rhizoma Smilacis Chinensis 160g, Herba Stephaniae Longae 230g, Fel Bovis seu Bubali 160g, Lignum Dalbergiae Odoriferae 230g, Ludwigia octovalvis (Jacq.) Raven 150g, Fructus Tamarindi Indicae 280g, fruit-rind of Chinese trichosanthes 320g, Radix clematidis floridae 120g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 270g, red oxtail seven 180g, Mirabilitum 110g, Radix Malvae sylvestris 160g, Neocheiropteris palmatopedata(Bak.) Christ 190g, Semen abutili indici 220g, Semen Aleuritis Moluccanae 240g, Caulis Sargentodoxae 180g, enrich blood potato 240g and Radix Rhodiolae Dumulosae 160g.

Its preparation method comprises the following steps:

The first step, Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae and Ludwigia octovalvis (Jacq.) Raven are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Radix clematidis floridae, red oxtail seven, Mirabilitum, Radix Malvae sylvestris and Semen abutili indici are mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 4 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, then load in gelatine capsule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 25-36g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.46g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>42.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.32g crude drug/day/people, adult body weight in 60KG, average dosage is 0.139g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 30g) oral administration gavage Chinese medicine of the present invention is 609 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 13.26,25.43 and 42.32g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: all cases all derive from this Out-patient Department and inpatient, totally 140 examples, be divided into treatment group (70 example) and matched group (70 example) by medical sequencing.In treatment group 70 example, age 25-40 year, 36 years old mean age.Wherein, Cesarean esction 28 example, natural labor 42 example; The course of disease 4 weeks-2 months.In matched group 70 example, age 24-42 year, 37 years old mean age.Wherein Cesarean esction 26 example, natural labor 44 example; 4 weeks-7 weeks of the course of disease.All patients all meet the diagnostic criteria of difficulty in defecation after delivery.Experimental group and matched group be no significant difference (P≤0.01) on age and clinical symptoms, has comparability.

Diagnostic criteria: with reference to " new Chinese medicine guideline of clinical investigations ": puerperal, stool was involved and abstruse, or a few days is not understood, or the dry pain of defecation, be difficult to discharge; The constipation that should cause with other diseases is differentiated mutually.

Therapeutic Method:

Treatment group: oral Chinese medicine embodiment 1 granule of the present invention, each 15g, every day 3 times.Within 1 week, be 1 course for the treatment of, be used in conjunction 2 courses for the treatment of.

Matched group: oral administered compound aloe capsule (Hebei Wanbangfulin Medicine Industry Co., Ltd), each 2, every day 2 times.Within 1 week, be 1 course for the treatment of, be used in conjunction 2 courses for the treatment of.

Curative effect judging standard: clinical cure: clinical symptoms and sign all disappear, stool is normal, 1 time on the 1st, no abnormalities feel.Effective: clinical symptoms and sign take a turn for the better, and defecate normal, and defecate the next day of sometimes, just matter is harder.Invalid: sings and symptoms is substantially without improvement, and stool is difficulty still.

Therapeutic outcome: two groups treat 2 courses for the treatment of respectively after, statistical result is see table 1 and table 2.

Table 1 liang group treats Clinical efficacy comparison after 1 course for the treatment of respectively: (unit: example)

Group	Number of cases	Clinical cure	Take a turn for the better	Invalid	Total effective rate
						Treatment group	70	41	26	3	67(95.71％)
Matched group	70	23	30	17	53(75.71％)

As can be seen from Table 1, adopt treatment by Chinese herbs difficulty in defecation after delivery of the present invention, relative to matched group, on therapeutic effect, there is significant improvement.

After 1 course for the treatment of of table 2 liang group treatment, clinical cure number and time compare: (unit: example)

Group	Number of cases	Medication 7 days	Medication 10 days	Medication 14 days
					Treatment group	41	17(24.29％)	28(40％)	41(58.57％)
Matched group	23	8(11.43％)	14(20％)	23(32.86)

As can be seen from Table 2, adopt treatment by Chinese herbs difficulty in defecation after delivery of the present invention, relative to matched group, not only better efficacy, takes effect faster.

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, the advantage of safe without toxic side effect.

Concrete case: patient, female, 29 years old, Cesarean esction, was admitted to hospital because of difficult defecation and sees a doctor, and private prosecution occurs being hard and dry 5 days puerperal, and a few days is not understood, and during solution under involved and abstruse difficulty, has blood in stool.On inspection except above-mentioned symptom, patient's shallow complexion, skin does not moisten, abdominal distention indigestion, light red tongue, thin fur, and deficient pulse is puckery, is diagnosed as difficulty in defecation after delivery.The granule of oral administration inventive embodiments 1, each 15g, every day 3 times, medication the 3rd day defecation, medication 1 week rear clinical symptoms and sign all disappear, and stool is normal, 1 time on the 1st, no abnormalities feel, clinical recovery, follows up a case by regular visits to 1 month without recurrence.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat the Chinese medicine preparation of difficulty in defecation after delivery for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae, Ludwigia octovalvis (Jacq.) Raven, Fructus Tamarindi Indicae, the fruit-rind of Chinese trichosanthes, Radix clematidis floridae, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, red oxtail seven, Mirabilitum, Radix Malvae sylvestris, Neocheiropteris palmatopedata(Bak.) Christ, Semen abutili indici, Semen Aleuritis Moluccanae, Caulis Sargentodoxae, enrich blood potato and Radix Rhodiolae Dumulosae.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: 10 ~ 25 parts, Air Bladder pseudosciaenae seu Acipenser, 15 ~ 25 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 10 ~ 30 parts, Herba Stephaniae Longae 10 ~ 25 parts, Fel Bovis seu Bubali 10 ~ 25 parts, Lignum Dalbergiae Odoriferae 15 ~ 30 parts, Ludwigia octovalvis (Jacq.) Raven 10 ~ 25 parts, Fructus Tamarindi Indicae 10 ~ 30 parts, the fruit-rind of Chinese trichosanthes 20 ~ 35 parts, Radix clematidis floridae 10 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 15 ~ 30 parts, red oxtail 7 10 ~ 30 parts, Mirabilitum 10 ~ 25 parts, Radix Malvae sylvestris 10 ~ 25 parts, Neocheiropteris palmatopedata(Bak.) Christ 10 ~ 20 parts, Semen abutili indici 10 ~ 30 parts, Semen Aleuritis Moluccanae 10 ~ 30 parts, Caulis Sargentodoxae 10 ~ 20 parts, to enrich blood potato 15 ~ 25 parts and Radix Rhodiolae Dumulosae 10 ~ 25 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: 10 ~ 15 parts, Air Bladder pseudosciaenae seu Acipenser, 20 ~ 25 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 15 ~ 25 parts, Herba Stephaniae Longae 15 ~ 25 parts, Fel Bovis seu Bubali 15 ~ 20 parts, Lignum Dalbergiae Odoriferae 20 ~ 25 parts, Ludwigia octovalvis (Jacq.) Raven 15 ~ 20 parts, Fructus Tamarindi Indicae 20 ~ 30 parts, the fruit-rind of Chinese trichosanthes 25 ~ 35 parts, Radix clematidis floridae 10 ~ 15 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20 ~ 30 parts, red oxtail 7 15 ~ 25 parts, Mirabilitum 10 ~ 15 parts, Radix Malvae sylvestris 15 ~ 20 parts, Neocheiropteris palmatopedata(Bak.) Christ 15 ~ 20 parts, Semen abutili indici 20 ~ 30 parts, Semen Aleuritis Moluccanae 15 ~ 25 parts, Caulis Sargentodoxae 15 ~ 20 parts, to enrich blood potato 20 ~ 25 parts and Radix Rhodiolae Dumulosae 15 ~ 25 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: 13 parts, Air Bladder pseudosciaenae seu Acipenser, 23 parts, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis 20 parts, Herba Stephaniae Longae 21 parts, Fel Bovis seu Bubali 18 parts, Lignum Dalbergiae Odoriferae 22 parts, Ludwigia octovalvis (Jacq.) Raven 18 parts, Fructus Tamarindi Indicae 25 parts, the fruit-rind of Chinese trichosanthes 26 parts, Radix clematidis floridae 15 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 25 parts, red oxtail 7 23 parts, Mirabilitum 13 parts, Radix Malvae sylvestris 18 parts, Neocheiropteris palmatopedata(Bak.) Christ 16 parts, Semen abutili indici 25 parts, Semen Aleuritis Moluccanae 20 parts, Caulis Sargentodoxae 15 parts, enrich blood potato 22 parts and Radix Rhodiolae Dumulosae 20 parts.

5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae and Ludwigia octovalvis (Jacq.) Raven are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix clematidis floridae, red oxtail seven, Mirabilitum, Radix Malvae sylvestris and Semen abutili indici are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and it comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, Air Bladder pseudosciaenae seu Acipenser, Cornu Cervi Pantotrichum, Rhizoma Smilacis Chinensis, Herba Stephaniae Longae, Fel Bovis seu Bubali, Lignum Dalbergiae Odoriferae and Ludwigia octovalvis (Jacq.) Raven are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Radix clematidis floridae, red oxtail seven, Mirabilitum, Radix Malvae sylvestris and Semen abutili indici are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.