CN104474430A - Traditional Chinese medicine for treating liver-kidney yin deficiency type mycotic vaginitis and preparation method - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating liver-kidney yin deficiency type mycotic vaginitis and a preparation method. Raw materials of the traditional Chinese medicine comprises comprise radix sophorae flavescentis, radix stemonae, golden cypress, catechu, fructus cnidii, peppers, polygonum aviculare, edible amaranths, clematis apiifolia, vaccinium bracteatum leaves, geckoes, rhizoma dioscoreae colletii, fructus galangae, celosia argentea, bistort rhizomes and pleioblastus amarus. The traditional Chinese medicine is used for treating liver-kidney yin deficiency type mycotic vaginitis according to the theory of traditional Chinese medicine of China and has the advantages that the curative effect is definite, the treatment course is short, side effects are small and liver-kidney yin deficiency type mycotic vaginitis is unlikely to relapse.

Description

A kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency colpitis mycotica

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency colpitis mycotica.

Background technology

Colpitis mycotica or monilial vaginitis and false silk candidiasis (VVC) of vulvovaginal are by the microbial a kind of common multiple vulvovaginal inflammation disease of beads.Patients symptomatic is pruritus vulvae mainly, and heavy time light during pruritis, time when sending out only, feeling restless when pruritus is serious, also may there is urodynia, sexual anhedonia etc. when inflammation is heavier in sleeping and eating difficulty peace.Leucorrhoea grow in quantity is another cardinal symptom of primary disease, and leucorrhea is generally very thick, in bean dregs sample or curdling block.Doctor trained in Western medicine generally adopts Mycoporin vaginal bolt to treat, but effect is general, and has certain side effect.

Colpitis mycotica belongs to the sick category such as the traditional Chinese medical science " pudendal pruritus ", " leukorrhagia ".Chinese medicine thinks its cause of disease mainly spleen insufficiency, endogenous damp formation, bet perineum, and strongly fragrant heat-transformation of a specified duration is infested; Or the heresy that diseases caused by exogenous pathogenic factor are damp and hot, follow through bet, corrode in the moon and send out primary disease.

By Chinese medical discrimination, be mainly divided into following amphitypy:

1, liver-kidney yin deficiency: main manifestations is recurrent exerbation, prolonged unhealed, leucorrhea is light white or yellowish, and amount is few, occasionally has pruritus, and companion sees restlessness and thirst, feverish sensation over the palm etc.

2, noxious dampness stagnation type: cardinal symptom is profuse leukorrhea, yellow skin is white, as bean dregs sample, frowziness, or leukorrhagia accompanies the blood streak, pudendal pruritus, and even red and swollen, fester, frequent micturition, urgent micturition, dysurea, defecate not well, white and greasy fur, rolling pulse.

3, insufficiency of the spleen damp-heat type: disease sees that leukorrhagia is rare as water sample clearly, amount polychrome is white, seldom continuous, odorless, pruritus vulvae, causalgia, and complexion takes off white or sallow, and god is tired, anorexia, the sticky or bitter taste of mouth, loose stool, and light red tongue is fat, Tai Bai or greasy, relaxed and soft pulse or moisten number.Gynecologial examination visible nympha both sides mucosa and vaginal wall there is milky lamellar pseudomembrane to cover, clashes rear visible mucous hyperemia, edema.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine and preparation method for the treatment of liver-kidney yin deficiency colpitis mycotica, and Chinese medicine of the present invention is to treatment liver-kidney yin deficiency colpitis mycotica determined curative effect, and side effect is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of liver-kidney yin deficiency colpitis mycotica, described Chinese medicine comprises following raw medicinal material: Radix Sophorae Flavescentis, the Radix Stemonae, Cortex Phellodendri, catechu, Fructus Cnidii, Pericarpium Zanthoxyli, Herba Polygoni Avicularis, le Amaranthus mangostanus L., Caulis Clematidis apiifoliae, Folium Vaccinii Bracteati, Gecko, Rhizoma Smilacis, Fructus Galangae, Herba Celosiae argenteae, Rhizoma Bistortae and Germinatus Pleioblasti.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be: Radix Sophorae Flavescentis 10-30 part, Radix Stemonae 10-30 part, Cortex Phellodendri 10-30 part, catechu 1-10 part, Fructus Cnidii 10-30 part, Pericarpium Zanthoxyli 10-20 Fen ， Herba Polygoni Avicularis 10-20 Fen ， le Amaranthus mangostanus L. 15-25 part, Caulis Clematidis apiifoliae 20-35 part, Folium Vaccinii Bracteati 20-40 part, Gecko 15-30 part Rhizoma Smilacis 25-40 part, Fructus Galangae 10-30 part, Herba Celosiae argenteae 15-25 part, Rhizoma Bistortae 20-40 part and Germinatus Pleioblasti 15-30 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be: Radix Sophorae Flavescentis 15-30 part, Radix Stemonae 12-25 part, Cortex Phellodendri 12-25 part, catechu 5-10 part, Fructus Cnidii 15-25 part, Pericarpium Zanthoxyli 12-18 Fen ， Herba Polygoni Avicularis 12-18 Fen ， le Amaranthus mangostanus L. 18-23 part, Caulis Clematidis apiifoliae 22-32 part, Folium Vaccinii Bracteati 25-35 part, Gecko 18-25 part Rhizoma Smilacis 28-35 part, Fructus Galangae 18-23 part, Herba Celosiae argenteae 15-20 part, Rhizoma Bistortae 25-35 part and Germinatus Pleioblasti 18-25 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be again: Radix Sophorae Flavescentis 18 parts, the Radix Stemonae 23 parts, Cortex Phellodendri 20 parts, 8 parts, catechu, Fructus Cnidii 17 parts, Pericarpium Zanthoxyli 16 Fen ， Herba Polygoni Avicularis 16 Fen ， le Amaranthus mangostanus L. 20 parts, Caulis Clematidis apiifoliae 28 parts, Folium Vaccinii Bracteati 28 parts, Gecko 22 parts of Rhizoma Smilacis 30 parts, Fructus Galangae 20 parts, Herba Celosiae argenteae 17 parts, Rhizoma Bistortae 28 parts and Germinatus Pleioblasti 22 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be: Radix Sophorae Flavescentis 16 parts, the Radix Stemonae 20 parts, Cortex Phellodendri 22 parts, 7 parts, catechu, Fructus Cnidii 15 parts, Pericarpium Zanthoxyli 14 Fen ， Herba Polygoni Avicularis 15 Fen ， le Amaranthus mangostanus L. 21 parts, Caulis Clematidis apiifoliae 26 parts, Folium Vaccinii Bracteati 29 parts, Gecko 23 parts of Rhizoma Smilacis 28 parts, Fructus Galangae 21 parts, Herba Celosiae argenteae 16 parts, Rhizoma Bistortae 27 parts, Germinatus Pleioblasti 23 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 6 ~ 8 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 400 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.1 ~ 0.2 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.01 ~ 0.05 times, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 90 ~ 120 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step: get a kind of in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer, two kinds of equivalent or equivalent each other is multiple as substrate each other; By described substrate heating and melting under DEG C condition of temperature 50 C ~ 60, add second step gained fine powder, stir, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

Beneficial effect of the present invention: the theory of Chinese medical science that Chinese medicine provided by the invention utilizes China traditional, has determined curative effect, short treating period to treatment liver-kidney yin deficiency colpitis mycotica, the little and advantage that not easily recurs of side effect.

Detailed description of the invention

The invention provides one and treat the colpitic Chinese medicine of liver-kidney yin deficiency mycotic, wherein, described Chinese medicine comprises following raw medicinal material: Radix Sophorae Flavescentis, the Radix Stemonae, Cortex Phellodendri, catechu, Fructus Cnidii, Pericarpium Zanthoxyli, Herba Polygoni Avicularis, le Amaranthus mangostanus L., Caulis Clematidis apiifoliae, Folium Vaccinii Bracteati, Gecko, Rhizoma Smilacis, Fructus Galangae, Herba Celosiae argenteae, Rhizoma Bistortae and Germinatus Pleioblasti.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Radix Sophorae Flavescentis: [another name] wild Chinese scholartree, Hao Hanzhi, matrine, bone, Chinese scholartree, Albizzia kalkora.This product is the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Spring, Qiu Erji excavate, removing root head and little supporting root, cleaning, drying, or take advantage of fresh slices, dry.Bitter in the mouth cold in nature.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.[extracts] " Chinese Pharmacopoeia "

The Radix Stemonae: [another name] Radix Stemonae, Herba delphinii grandiflori, noisy louse medicine, medicine louse medicine.This product is the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..Spring, Qiu Erji excavate, and removing fibrous root, cleans, and put in boiling water and slightly scald or steam to without the white heart, take out, dry.Slightly warm in nature, sweet in the mouth, hardship.Return lung meridian.Slightly poisonous.Nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.[extracts] " Chinese Pharmacopoeia "

Cortex Phellodendri: [another name] Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood.This product is the dry bark of rutaceae wampee Phellodendronchinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".After stripping bark, removing rough bark, dries.Bitter in the mouth cold in nature.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.[extracts] " Chinese Pharmacopoeia "

Catechu: [another name] CATECHU, Catechu, gambier.Dry branch for pulse family sallee catechu tree Acaciacatechu (L.) Willd. adds the dry extract that decocting juice concentrates.Cold nature is bitter in the mouth, puckery.Return lung meridian.Removing heat-phlegm, sore is stopped blooding.For cough due to lung-heat, spitting of blood, diarrhoea, infantile dyspepsia; External is controlled skin infection and is not closed up for a long time, skin eczema, aphtha, tonsillitis.[extracts] " national Chinese herbal medicine compilation "

Fructus Cnidii: [another name] wild Fructus Foeniculi, Daucus carota L., Serpentis rice, She Li.This product is the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss..Gather when summer, autumn two season fruit maturation, removing impurity, dries.Warm in nature, acrid in the mouth, hardship, slightly poisonous.Return kidney channel.Warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis.[extracts] " Chinese Pharmacopoeia "

Pericarpium Zanthoxyli: [another name] fragrant green pepper, large Pericarpium Zanthoxyli, Semen zanthoxyli.This product is that the dry mature skin (Pericarpium Zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) Zanthoxylum schinifolium Sieb.et Zucc. or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)) Zantho xylum bungeanum Maxim. and seed (Semen zanthoxyli) are used as medicine.To gather autumn mature fruit, remove impurity and dry.Separate for subsequent use with seed.Warm in nature, acrid in the mouth.Return spleen, stomach, kidney channel.Warming middle-JIAO to relieve pain, killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.[extracts] " Chinese Pharmacopoeia "

Herba Polygoni Avicularis: [another name] Herba Polygoni Avicularis, large Herba Polygoni Avicularis, bird knotweed, flat bamboo, Herba Commelinae Diffusae, Herba Ecliptae, road SHENGCAO.This product is the dry aerial parts of Liao section Zhi Wu Herba Polygoni Avicularis Polygonum aviculare L..Gather during leafiness in summer, removing root and impurity, dry.Cold nature, bitter in the mouth.Return urinary bladder channel.Inducing diuresis for treating stranguria syndrome, parasite killing, antipruritic.For bladder pyretic stranguria, oliguria with reddish urine, drenches the puckery pain of drop, skin eczema, pudendal pruritus leukorrhagia.[extracts] " Chinese Pharmacopoeia "

Le Amaranthus mangostanus L.: Herba Amaranthi tricoloris, thorn Herba Urticae Cannabinae, wild Amaranthusspinosus L. Lay, sour Herba Amaranthi tricoloris, Amaranthus spinosus L. are strangled in [another name] Amaranthusspinosus L., Herba amaranthi ascendentis, native Amaranthus mangostanus L., the female dish of pig, open country.For herb or the root of amaranthaceous plant Amaranthusspinosus L..Cold nature, sweet in the mouth.Cooling blood for hemostasis; Eliminating damp-heat; Removing toxicity for eliminating carbuncles.Main gastrorrhagia; Have blood in stool; Hemorrhoidal bleeding; Cholecystitis; Cholelithiasis; Dysentery; Diarrhea due to damp-heat; Leukorrhagia; Difficulty and pain in micturition; Laryngopharynx swelling and pain; Eczema; Carbuncle; Gingiva is rotten to the corn; Venom.[extracts] " China's book on Chinese herbal medicine "

Caulis Clematidis apiifoliae: [another name] climing Chu, Paeonia suffruticosa are climing, Caulis Clematidis Finetianae, Caulis Akebiae grass, Caulis Akebiae, wear that mountain rattan, Lignum Sappan are logical, lobule duck strength of one's legs just, key rattan, Caulis Clematidis pseudopogonandrae, chrysanthemum leaf Radix Clematidis.For the rattan of ranunculaceae plant Caulis Clematidis apiifoliae, leaf or root.Warm in nature, acrid in the mouth, slightly poisonous.Return liver; Spleen; Large intestine channel.Expelling wind and removing dampness, warming middle-JIAO is regulated the flow of vital energy, diuresis, helps digestion.Cure mainly rheumatism arthromyodynia, vomit and diarrhoea; Dysentery; The ring of stomachache intestinal; Dysuria; Edema.[extracts] " China's book on Chinese herbal medicine "

Folium Vaccinii Bracteati: [another name] Vaccinium bracteatum Thunb. branch and leaf.For the leaf of ericad Fructus Vaccinii Bracteati.8 ~ JIUYUE is gathered, and picks clean sprig and impurity, dries.The dry place of storage.Property is put down, and sour in the mouth is puckery.GUIXIN; Spleen; Kidney channel.Benefit the intestines and stomach; Nourishing the liver and kidney.Main deficiency of spleen-QI and stomach-QI; Chronic diarrhea; Few food; Deficiency of the liver and kindey; Waist knee joint is weak; Early whitening of beard and hair.[extracts] " Chinese medicine voluminous dictionary "

Gecko: this product is the dry body of Gekkonidae animal Gecko Gekko gecko Linnaeus.The whole year all can catch, removing internal organs, wipes clean, struts with bamboo chip, makes all flat straight, cold drying.Property is put down, salty in the mouth.Return lung, kidney channel.Invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence.For dyspnea due to deficiency tachypnea, chronic cough hemoptysis, impotence and seminal emission.[extracts] " Chinese Pharmacopoeia "

Rhizoma Smilacis: [another name] Chuan Rhizoma Dioscoreae Septemlobae (" Chinese crude drug handbook ").For the tuber of the multiple congeners such as liliaceous plant Rhizoma Smilacis Glabrae or powder Rhizoma Smilacis Chinensis.The whole year can adopt, and section is dried.Property is put down, bitter in the mouth (" Traditional Chinese Medicine in Sichuan will ").Return liver, stomach, kidney channel (" Traditional Chinese Medicine in Sichuan will "))." Traditional Chinese Medicine in Sichuan will ": wind-damp dispelling, divides pure and impure, sharp joint, separates sore.Dispelling the wind and dampness pathogens pain, waist knee joint arthralgia pain.Stranguria with turbid discharge and syphilis malignant boil." choosing of Yunnan Chinese herbal medicine ": expelling wind and removing dampness, treating stranguria, diuretic, antiinflammatory, removing toxic substances.Treating rheumatic arthritis, urinary system infection, chronic gastritis, menoxenia, furuncle.[extracts] " Chinese medicine voluminous dictionary "

Fructus Galangae: this product is the dry mature fruit of zingiberaceous plant Rhizoma Alpiniae Galangae Alpinia galanga Willd..[nature and flavor] are pungent, temperature.[return through] returns spleen, lung meridian.[function cures mainly] dampness cold expelling, being amusing helps digestion.For coldness and pain in the epigastrium, food stagnation distension, vomiting is had loose bowels, drinking too much.[extracts] " Chinese Pharmacopoeia "

Herba Celosiae argenteae: be stem and leaf or the root of amaranthaceous plant Herba Celosiae argenteae.Latin plant animal mineral name: Celosia argenteaL.[nature and flavor] bitter; Cold in nature.[return through] liver; Urinary bladder channel.The heat clearing away of [function cures mainly] dampness; Killing parasites for relieving itching; Cooling blood for hemostasis.Main damp-heat vaginal discharge; Dysuria; Turbid urine; Have loose bowels; Pudendal pruritus; Skin ulcer scabies; Wind scabies itching over the body; Hemorrhoid; Epistaxis; Wound hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Bistortae: this product is the dry rhizome of polygonaceae plant Rhizoma Bistortae Polygonum bistorta L..[nature and flavor] are bitter, puckery, are slightly cold.[return through] returns lung, liver, large intestine channel.[function cures mainly] heat-clearing and toxic substances removing, detumescence, hemostasis.For bloody dysentery, diarrhea of heat type, cough due to lung-heat, carbuncle, scrofula, aphtha of the mouth and tongue, spits blood, epistaxis, bleeding hemorrhoids, venom.[extracts] " Chinese Pharmacopoeia "

Germinatus Pleioblasti: be the tender Seedling of grass bitter bamboo.[nature and flavor] are bitter; Cold.[function cures mainly] clearing heat and relieving fidgetness; Dehumidifying; Diuretic.Main calentura excessive thirst; Jaundice due to damp-heat; Dysuria; Beriberi.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Sophorae Flavescentis 10-30 part, Radix Stemonae 10-30 part, Cortex Phellodendri 10-30 part, catechu 1-10 part, Fructus Cnidii 10-30 part, Pericarpium Zanthoxyli 10-20 part Herba Polygoni Avicularis 10-20 Fen ， le Amaranthus mangostanus L. 15-25 part, Caulis Clematidis apiifoliae 20-35 part, Folium Vaccinii Bracteati 20-40 part, Gecko 15-30 part, Rhizoma Smilacis 25-40 part, Fructus Galangae 10-30 part, Herba Celosiae argenteae 15-25 part, Rhizoma Bistortae 20-40 part and Germinatus Pleioblasti 15-30 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be: Radix Sophorae Flavescentis 15-30 part, Radix Stemonae 12-25 part, Cortex Phellodendri 12-25 part, catechu 5-10 part, Fructus Cnidii 15-25 part, Pericarpium Zanthoxyli 12-18 Fen ， Herba Polygoni Avicularis 12-18 Fen ， le Amaranthus mangostanus L. 18-23 part, Caulis Clematidis apiifoliae 22-32 part, Folium Vaccinii Bracteati 25-35 part, Gecko 18-25 part Rhizoma Smilacis 28-35 part, Fructus Galangae 18-23 part, Herba Celosiae argenteae 15-20 part, Rhizoma Bistortae 25-35 part and Germinatus Pleioblasti 18-25 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be again: Radix Sophorae Flavescentis 18 parts, the Radix Stemonae 23 parts, Cortex Phellodendri 20 parts, 8 parts, catechu, Fructus Cnidii 17 parts, Pericarpium Zanthoxyli 16 Fen ， Herba Polygoni Avicularis 16 Fen ， le Amaranthus mangostanus L. 20 parts, Caulis Clematidis apiifoliae 28 parts, Folium Vaccinii Bracteati 28 parts, Gecko 22 parts of Rhizoma Smilacis 30 parts, Fructus Galangae 20 parts, Herba Celosiae argenteae 17 parts, Rhizoma Bistortae 28 parts, Germinatus Pleioblasti 22 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be: Radix Sophorae Flavescentis 16 parts, the Radix Stemonae 20 parts, Cortex Phellodendri 22 parts, 7 parts, catechu, Fructus Cnidii 15 parts, Pericarpium Zanthoxyli 14 Fen ， Herba Polygoni Avicularis 15 Fen ， le Amaranthus mangostanus L. 21 parts, Caulis Clematidis apiifoliae 26 parts, Folium Vaccinii Bracteati 29 parts, Gecko 23 parts of Rhizoma Smilacis 28 parts, Fructus Galangae 21 parts, Herba Celosiae argenteae 16 parts, Rhizoma Bistortae 27 parts, Germinatus Pleioblasti 23 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 6 ~ 8 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 400 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.1 ~ 0.2 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.01 ~ 0.05 times, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, described Chinese medicine is decoction, and its preparation method comprises the following steps:

The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

4th: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: tablet

Get Radix Sophorae Flavescentis 180g, Radix Stemonae 230g, Cortex Phellodendri 200g, catechu 80g, Fructus Cnidii 170g, Pericarpium Zanthoxyli 160g ， Herba Polygoni Avicularis 160g ， le Amaranthus mangostanus L. 200g, Caulis Clematidis apiifoliae 280g, Folium Vaccinii Bracteati 280g, Gecko 220g, Rhizoma Smilacis 300g, Fructus Galangae 200g, Herba Celosiae argenteae 170g, Rhizoma Bistortae 280g and Germinatus Pleioblasti 220g.

Prepare according to the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 6 times is the ethanol of 95%, reflux 3 hours, extract, filter acquisition first extracting solution, it is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 times again, reflux 1 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 300 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 times, the lactose of 0.2 times, the starch of 0.2 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.02 times, granulate, tabletting, makes.

Embodiment 2: suppository

Get Radix Sophorae Flavescentis 160g, Radix Stemonae 200g, Cortex Phellodendri 220g, catechu 70g, Fructus Cnidii 150g, Pericarpium Zanthoxyli 140g ， Herba Polygoni Avicularis 150g ， le Amaranthus mangostanus L. 210g, Caulis Clematidis apiifoliae 260g, Folium Vaccinii Bracteati 290g, Gecko 230g, Rhizoma Smilacis 280g, Fructus Galangae 210g, Herba Celosiae argenteae 160g, Rhizoma Bistortae 270g and Germinatus Pleioblasti 230g.

Prepare according to the following steps:

The dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 33 hours under the condition of 6 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 100 minutes at this, the micron particles of acquisition 1 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step: get two kinds of semi-synthetic fatty acid glyceride and poloxamer poloxamer equivalent each other as substrate; By described substrate heating and melting under temperature 60 C condition, add second step gained fine powder, stir, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 3; Described tampon is the tampon of afterbody with cotton thread.

Toxicity test:

Acute toxicity testing: application mice 80, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 7.54g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 37.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>37.7 crude drug/kg, every day, maximum dosage-feeding was 75.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 7.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.12g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 628 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention presses 13.35,19.26 and 38.33g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 100 routine cases are my institute patient in August, 2011 ~ in October, 2013.Be divided into treatment group and matched group at random, wherein treatment group 50 people, 18 ~ 53 years old age; Matched group 50 people, 19 ~ 52 years old age.Two groups in age and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05), there is comparability.

Diagnostic criteria: meet following Western medicine diagnose standard and Syndrome Types of TCM diagnostic criteria.

Western medicine diagnose standard: with reference to the diagnostic criteria of colpitis mycotica in " practical department of obstetrics and gynecology pharmacotherapeutics ".1, vulvovaginal portion pruritus, even uneasy in either sitting or lying of sometimes very itching; 2, vaginal secretions increases, in curdy or bean dregs sample; 3, inside the visible nympha of gynecologial examination and vaginal mucosa adhere to white membranoid substance, mucosa is congested red and swollen; 4, vaginal secretions plate coating checking is shown in spore and the mycelia of typical candidiasis; 5, vagina PH value≤4.5.

Syndrome Types of TCM diagnostic criteria: the hepatic and renal YIN deficiency: main manifestations is recurrent exerbation, prolonged unhealed, leucorrhea is light white or yellowish, and amount is few, occasionally has pruritus, and companion sees restlessness and thirst, feverish sensation over the palm etc.

Therapeutic Method:

Treatment group: take the embodiment of the present invention 1 tablet every day 3 times, each 37 days is a course for the treatment of;

Matched group: clean pudendum, vagina before sleeping every night, is placed in vagina depths by miconazole (Xi'an Janssen Pharmaceutica).1 time every night, one time 1 piece.It within continuous 7 days, is a course for the treatment of.

Curative effect judging standard: cure: clinical symptoms and sign disappear completely, vaginal secretions inspection prompting mycete is negative, and menstruation in continuous 3 months is only checked mycete afterwards and is feminine gender.Effective: clinical symptoms and sign substantially disappear or only have slight pruritus vulvae and a small amount of leucorrhea, vaginal secretions inspection display mycete is positive, after second course of therapy, check mycete transfer feminine gender to, then menstruation in continuous 2 months only afterwards check mycete be feminine gender.Invalid: through a course of therapy, clinical symptoms, without obviously alleviating, checks mycete still for positive after two courses for the treatment of.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1, adopt treatment by Chinese herbs liver-kidney yin deficiency colpitis mycotica of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs liver-kidney yin deficiency colpitis mycotica of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After table 1 liang group treats 1 course for the treatment of respectively, Clinical efficacy comparison is routine

Group	n	Cure	Effectively	Invalid	Effectively total
						Treatment group	50	24	25	1	49(98％)
Matched group	50	11	30	9	41(82％)

Number and time comparative example (%) is cured after a table 2 liang group treats 1 course for the treatment of respectively

Group	Number of cases	Medication 3 days	Medication 5 days	Medication 7 days
					Treatment group	24	3(12.5％)	14(58.3％)	7(29.2％)
Matched group	11	0(0％)	4(36.4％)	7(63.6％)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Follow up a case by regular visits to 1 year respectively to the 11 routine patients that 24 routine patients and the matched group for the treatment of group healing are cured, result is added up, and treatment group is without recurrence, and relapse rate is 0% simultaneously; The routine patient of matched group 11, recurs 2 people, relapse rate 18.2%.

Concrete case: Wei, female, 30 years old, suffers from colpitis mycotica 1.5 years, repeatedly treat, within after drug withdrawal 1 ~ 3 month, namely recur, admission examination: pudendum is even pruritus, sometimes with causalgia sense, gynecologial examination pudendum, vaginal mucosa flushing, adhere to white membranoid substance inside nympha and in vaginal mucosa.Vaginal secretions is white curdy.Lab testing vaginal secretions sessile drop method finds spore and pseudohypha under the microscope, and namely mycete is positive.According to its tcm symptom: recurrent exerbation, prolonged unhealed, leucorrhea is in vain light, and amount is few, and occasionally have pruritus, restlessness and thirst, feverish sensation over the palm, further Syndrome Types of TCM is liver-kidney yin deficiency colpitis mycotica.Take the embodiment of the present invention 1 tablet, every day 3 times, each 3, treat 5 days, the clinical symptoms such as pruritus and causalgia sense and various sign disappear completely, and vaginal secretions inspection prompting mycete is negative, drug withdrawal, menstruation in continuous 3 months is only checked mycete afterwards and is feminine gender, follows up a case by regular visits to and does not recur for 1 year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for liver-kidney yin deficiency colpitis mycotica, it is characterized in that comprising following prescription: Radix Sophorae Flavescentis, the Radix Stemonae, Cortex Phellodendri, catechu, Fructus Cnidii, Pericarpium Zanthoxyli, Herba Polygoni Avicularis, le Amaranthus mangostanus L., Caulis Clematidis apiifoliae, Folium Vaccinii Bracteati, Gecko, Rhizoma Smilacis, Fructus Galangae, Herba Celosiae argenteae, Rhizoma Bistortae, Germinatus Pleioblasti.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sophorae Flavescentis 10-30 part, Radix Stemonae 10-30 part, Cortex Phellodendri 10-30 part, catechu 1-10 part, Fructus Cnidii 10-30 part, Pericarpium Zanthoxyli 10-20 Fen ， Herba Polygoni Avicularis 10-20 part le Amaranthus mangostanus L. 15-25 part, Caulis Clematidis apiifoliae 20-35 part, Folium Vaccinii Bracteati 20-40 part, Gecko 15-30 part, Rhizoma Smilacis 25-40 part, Fructus Galangae 10-30 part, Herba Celosiae argenteae 15-25 part, Rhizoma Bistortae 20-40 part, Germinatus Pleioblasti 15-30 part.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sophorae Flavescentis 15-30 part, Radix Stemonae 12-25 part, Cortex Phellodendri 12-25 part, catechu 5-10 part, Fructus Cnidii 15-25 part, Pericarpium Zanthoxyli 12-18 Fen ， Herba Polygoni Avicularis 12-18 part le Amaranthus mangostanus L. 18-23 part, Caulis Clematidis apiifoliae 22-32 part, Folium Vaccinii Bracteati 25-35 part, Gecko 18-25 part, Rhizoma Smilacis 28-35 part, Fructus Galangae 18-23 part, Herba Celosiae argenteae 15-20 part, Rhizoma Bistortae 25-35 part, Germinatus Pleioblasti 18-25 part.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sophorae Flavescentis 18 parts, the Radix Stemonae 23 parts, Cortex Phellodendri 20 parts, 8 parts, catechu, Fructus Cnidii 17 parts, Pericarpium Zanthoxyli 16 Fen ， Herba Polygoni Avicularis 16 parts of le Amaranthus mangostanus L.s 20 parts, Caulis Clematidis apiifoliae 28 parts, Folium Vaccinii Bracteati 28 parts, Gecko 22 parts, Rhizoma Smilacis 30 parts, Fructus Galangae 20 parts, Herba Celosiae argenteae 17 parts, Rhizoma Bistortae 28 parts, Germinatus Pleioblasti 22 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sophorae Flavescentis 16 parts, the Radix Stemonae 20 parts, Cortex Phellodendri 22 parts, 7 parts, catechu, Fructus Cnidii 15 parts, Pericarpium Zanthoxyli 14 Fen ， Herba Polygoni Avicularis 15 parts of le Amaranthus mangostanus L.s 21 parts, Caulis Clematidis apiifoliae 26 parts, Folium Vaccinii Bracteati 29 parts, Gecko 23 parts, Rhizoma Smilacis 28 parts, Fructus Galangae 21 parts, Herba Celosiae argenteae 16 parts, Rhizoma Bistortae 27 parts, Germinatus Pleioblasti 23 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 6 ~ 8 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 400 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.1 ~ 0.2 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.01 ~ 0.05 times, granulate, tabletting, makes.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 90 ~ 120 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step: get a kind of in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer, two kinds of equivalent or equivalent each other is multiple as substrate each other; By described substrate heating and melting under DEG C condition of temperature 50 C ~ 60, add second step gained fine powder, stir, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 6 ~ 8 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extract, filter acquisition first extracting solution, it is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 ~ 4 times again, reflux 1 ~ 2 hour, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 400 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the lactose of 0.1 ~ 0.2 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.01 ~ 0.05 times, granulate, tabletting, makes.

9. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is suppository, and its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 90 ~ 120 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step: get a kind of in semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol and poloxamer poloxamer, two kinds of equivalent or equivalent each other is multiple as substrate each other; By described substrate heating and melting under DEG C condition of temperature 50 C ~ 60, add second step gained fine powder, stir, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes bullet-shaped suppository; The proportioning of described fine powder and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.