CN105687735A - Traditional Chinese medicine preparation for treating diabetes insipidus and preparation method thereof - Google Patents
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Abstract
The invention provides a traditional Chinese medicine preparation for treating diabetes insipidus and a preparation method thereof. The traditional Chinese medicine preparation is prepared from Petelot Habenaria, root tubers of Habenaria delavayi Finet, all grass of Ainsliaea spicata Vant, Chinese cabbage, root tubers of Potentilla anserina L., fruit of Schisandra rubriflora (Franch.) Rehd. et Wils, herb of Little Platanthera, Semen Juglandis, roots of Chinese Eriosema, Salvia chinensis Benth., fruit of Greywhitehair Raspberry, dry freshwater sponges, ginseng rhizome, rhizome of Kamchatka Bugbane, leaves of rice beans, all grass of Dewberryleaf Cinquefoil, Ballflower conehead and rhizome of Largeleaf Japanese Ginseng. The preparation has the advantages that use is safe and convenient, the treatment effect is good when the preparation is used in cooperation with western medicine for treating diabetes insipidus, no toxic and side effects or adverse reaction is caused, the effect is quick, diabetes insipidus is not prone to relapsing, and the preparation process is simple.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation treating diabetes insipidus and preparation method thereof。
Background technology
Diabetes insipidus (diabetesinsipidus) refers to that diuresis swashs the disease group that vassopressin reaction defect is caused by (antidiuretichormone, ADH) hyposecretion or kidney。It is lose urine concentrating function wholly or in part due to patient, with polydipsia, polyuria, the low clinical syndrome for feature of specific gravity of urine。It is characterized in polyuria, excessive thirst, low-gravity urine and hypotonic urine。Pituitary diabetes insipidus is found in any age, generally childhood period or grow up early stage morbidity, male is common compared with women, and the ratio of men and women is 2:1。Pathological changes, hypothalamus-neurohypophysis person, is called central diabetes insipidus or pituitary diabetes insipidus；Pathological changes, kidney person, is called nephrogenic diabetes insipidus。Diabetes insipidus has Different types of etiopathogenises。One is that hypothalamic function is not normal to be produced to reduce with vassopressin。It two is that hormone cannot be released into blood by hypophysis。Additionally hypothalamus or hypophysis surgical injury, craniocerebral trauma, especially fracture of skull base, tumor, sarcoidosis or tuberculosis, cerebral aneurysm or obstruction of artery cause that encephalitis or meningitis and rare histiocytosis's (Chinese-permitted-klinefelter syndrome) etc. are also the major reasons bringing out diabetes insipidus。AVP is one 9 peptide synthesized by necleus of hypothalamus,supraoptic and paraventricular nucleus neurocyte, and its encoding gene is positioned at the secretion of 20p130AVP and is affected by several factors, most important of which is that the osmotic pressure of extracellular fluid and blood volume。Being positioned at the osmoreceptor near necleus of hypothalamus,supraoptic and thirst center and control secretion and the drinking behavior of AVP simultaneously, human normal plasma's osmotic pressure is 280～290mmol/L, and fluctuation range is ± 1.8%。
Clinical manifestation is: 1. the clinical syndrome that this disease is is feature with low milliosmolarity polyuria, and its notable symptom is exactly polyuria, patient's drinking a lot of water (can more than 3000ml/m2), and urine volume was up to every 24 hours 2.5-20L, even more, reached 40I/d person it have been reported that have。2. urine density ratio is more fixing, and specific gravity of urine is low and fixing。In continuing low-density urine, urine density is less than 1.006。Most < the 200mmol/L of osmotic pressure of urine。3. onset is slow, and minority is onset suddenly, excessive thirst, polydipsia and desire for cold drinks occurs。4. there is dehydration, xerosis cutis, cardiopalmus in some patients。Sweat & saliva can being had to reduce, companion's constipation, weak, headache, dizziness, anxiety, insomnia, agitation, hypomnesis, become thin, severe patient can have electrolyte disturbance, visual deterioration。5. hereditary diabetes insipidus person is often in onset childhood, because of thirst center hypoplasia, can cause serious dehydration and hypernatremia, normal threat to life。6. when tumor and craniocerebral trauma and operation involve thirst center, except localizing symptoms, it is possible to hypernatremia occurs。Serious hypernatremia shows as delirium, spasm, vomiting etc.。7. when diabetes insipidus merges adenohypophysis functional defect, symptoms of DI can alleviate, and after sugar (salt) replacement of cortical hormone, symptom reproduces or increases the weight of。
Motherland's medical science thinks kidney governing bones, and waist is house of kidney, suffers from a deficiency of the kidney therefore sees soreness of the waist and knees。Red tongue with yellow fur, thready and weak pulse be kidney yin, insufficiency of kidney-YANG as。This disease patient's ferritic deficiency of YIN, as having eating and drinking without temperance, disorder of emotion again, labor is intended to excessively, causes scorching Sheng, and cloudy Tianjin is exhausted, easily causes primary disease and occurs。Such as thermal burn stomach-Yin, body fluid dries up, then excessive thirst polydipsia；Thermal burn kidney yin, then body fluid outflow, causes and urinates more。Kidney controlling urination and defecation, the diabetes insipidus that wound causes, its etiology and pathogenesis: be then just blood stasis, disease for a long time must the deficiency of vital energy, cause deficiency of kidney-QI, astringency inducing is invalid, and causes polyuria。
Summary of the invention
The technical problem to be solved is in that, utilizes the theory of Chinese medical science that China is traditional, it is provided that a kind of determined curative effect and the little Chinese medicine preparation for the treatment of diabetes insipidus of toxic action and preparation method thereof。
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine preparation treating diabetes insipidus, described Chinese medicine preparation includes following raw medicinal material: Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae, the Yunnan five tastes, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy, Spongilla, Rhizoma Ginseng, Rhizoma cimicifugae simplicis, Folium Phaseoli, Herba Potentillae Fragarioidis, Strobilanthes sarcorrhizus Cling and Rhizoma panacis majoris。
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Habenria petelotii Gagnep. 15～25 parts, Radix Habenariae Delavayi 10～20 parts, Herba Ainsliaeae ovovatae 5～15 parts, Plantula Brassicae chinensis 15～30 parts, Radix potentillae anserinae 25～35 parts, the Yunnan five tastes 20～30 parts, Herba platantherae minoris 15～30 parts, Partition in Fructus Juglandis 15～25 parts, Radix eriosematis chinensis 15～30 parts, Herba Salviae Chinensis 20～30 parts, fluffy 15～25 parts, Spongilla 30～40 parts, Rhizoma Ginseng 15～30 parts, Rhizoma cimicifugae simplicis 5～15 parts, Folium Phaseoli 25～35 parts, Herba Potentillae Fragarioidis 15～30 parts, Strobilanthes sarcorrhizus Cling 15～25 parts and Rhizoma panacis majoris 5～15 parts。
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Habenria petelotii Gagnep. 20～25 parts, Radix Habenariae Delavayi 15～20 parts, Herba Ainsliaeae ovovatae 5～10 parts, Plantula Brassicae chinensis 20～25 parts, Radix potentillae anserinae 30～35 parts, the Yunnan five tastes 25～30 parts, Herba platantherae minoris 15～20 parts, Partition in Fructus Juglandis 15～20 parts, Radix eriosematis chinensis 20～25 parts, Herba Salviae Chinensis 25～30 parts, fluffy 15～20 parts, Spongilla 30～35 parts, Rhizoma Ginseng 15～20 parts, Rhizoma cimicifugae simplicis 5～10 parts, Folium Phaseoli 25～30 parts, Herba Potentillae Fragarioidis 20～25 parts, Strobilanthes sarcorrhizus Cling 15～20 parts and Rhizoma panacis majoris 10～15 parts。
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Habenria petelotii Gagnep. 21 parts, Radix Habenariae Delavayi 18 parts, Herba Ainsliaeae ovovatae 7 parts, Plantula Brassicae chinensis 25 parts, Radix potentillae anserinae 31 parts, the Yunnan five tastes 28 parts, Herba platantherae minoris 16 parts, Partition in Fructus Juglandis 16 parts, Radix eriosematis chinensis 21 parts, Herba Salviae Chinensis 29 parts, fluffy 17 parts, Spongilla 35 parts, Rhizoma Ginseng 16 parts, Rhizoma cimicifugae simplicis 9 parts, Folium Phaseoli 26 parts, Herba Potentillae Fragarioidis 24 parts, Strobilanthes sarcorrhizus Cling 16 parts and Rhizoma panacis majoris 14 parts。
When the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule。
When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae and the Yunnan five tastes are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby；It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C；
Second step, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy and Spongilla are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30；
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder；
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule。
Beneficial effects of the present invention: the Chinese medicine preparation that diabetes insipidus of the present invention uses is safe and convenient to use, associating western medicine diabetes insipidus therapeutic effect is good, has no side effect and untoward reaction, and instant effect not easily recurs, and preparation technology is simple。
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation treating diabetes insipidus, Chinese medicine preparation includes following raw medicinal material: Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae, the Yunnan five tastes, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy, Spongilla, Rhizoma Ginseng, Rhizoma cimicifugae simplicis, Folium Phaseoli, Herba Potentillae Fragarioidis, Strobilanthes sarcorrhizus Cling and Rhizoma panacis majoris。
The pharmacology of various raw medicinal materials is as follows:
Habenria petelotii Gagnep.: [another name] Herba Habenariae rhodochellae。[source] medical material Ji Yuan: for the tuber of orchid rip-panel jade phoenix flower。[nature and flavor] are sweet；Flat。[return through] lung；Liver；Kidney channel。[function cures mainly] the kidney invigorating lung heat clearing。Main lumbago due to renal deficiency；Sexual impotence；Bed-wetting；Hernia；Cough due to lung-heat。[each discussion] " Xinhua's book on Chinese herbal medicine outline ": cure mainly lumbago due to renal deficiency, cough due to lung-heat, traumatic hemorrhage, sexual impotence, hernia, juvenile's enuresis。[extracts] " China's book on Chinese herbal medicine "
Radix Habenariae Delavayi: [another name] Radix Satyrii nepalensis, Kunming two aspidistra, twoflower rattlesnake plantain, pairing grass。[source] medical material Ji Yuan: for the tuber of orchid thickness lobe jade phoenix flower。[nature and flavor] are sweet；Micro-pungent；Temperature。[return through] kidney channel。[function cures mainly] replenishing kidney, strengthening waist；Regulating QI to relieve pain。Main lumbago due to renal deficiency；Hernia；The stagnation of QI is had a stomachache。[extracts] " China's book on Chinese herbal medicine "
Herba Ainsliaeae ovovatae: [another name] Folium Pruni Ainsliaea fragrans Champ., strive leaf, Herba Calthae Membranaceae。[source] medical material Ji Yuan: for the herb of feverfew Acanthopanax obovatus Hoo Ainsliaea fragrans Champ.。[nature and flavor] mildly bitter flavor；Cool in nature。[function cures mainly] heat clearing away；Dampness removing；Cough-relieving；Removing toxic substances。Main acute and chronic kidney fire；Nephropyelitis；Cystitis；Bronchitis；Dysentery；Weapons are hindered。[extracts] " China's book on Chinese herbal medicine "
Plantula Brassicae chinensis: [another name] Chinese cabbage, summer ancient name for Chinese cabbage, green vegetable。[source] medical material Ji Yuan: for the leaf of crucifer green vegetable。[nature and flavor] are sweet；Cool。[return through] intestinal；Stomach warp。[function cures mainly] antipyretic relieving restlessness；Promoting the production of body fluid to quench thirst；Lung heat clearing expectorant；Tonneau the intestines and stomach。Main cough due to lung-heat；Constipation；Quench one's thirst；Food stagnation；Erysipelas；Dermatitis rhus。[each discussion] 1. " not Lu ": main tonneau the intestines and stomach, except restlessness in the chest, relieves the effect of alcohol thirsty。2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": main expectorant, cough-relieving is coughed, diuresis, clearing away lung-heat。[extracts] " China's book on Chinese herbal medicine "
Radix potentillae anserinae: [another name] Radix potentillae anserinae, deer run grass, Herba Herminii。[source] medical material Ji Yuan: for the tuber of rosaceous plant Radix potentillae anserinae。[nature and flavor] are sweet；Bitter；Cold。[return through] spleen；Stomach warp。[function cures mainly] fills blood；Strengthening the spleen and stomach；Promoting the production of body fluid to quench thirst。Main diarrhea due to hypofunction of the spleen；Anemia after being ill；Malnutrition；Edema；Rheumatic arthralgia。[extracts] " China's book on Chinese herbal medicine "
The Yunnan five tastes: [source] medical material Ji Yuan: for the mature fruit of Schisandraceae Plant Schisandra sphnanthera。[nature and flavor] acid；Sweet；Warm in nature。[return through] lung；The heart；Kidney channel。[function cures mainly] restrains astringent or styptic treatment for spontaneous sweating；Supplementing QI for promoting the production of body fluid；Kidney calming。Main chronic cough dyspnea due to deficiency；Emission；Enuresis frequent micturition；Incessant chronic diarrhea；Spontaneous perspiration；Night sweat；Tianjin wound is thirsty；Lose heart deficient pulse；Interior-heat is quenched one's thirst；Palpitation and insomnia。[extracts] " China's book on Chinese herbal medicine "
Herba platantherae minoris: [another name] Serpentis knotweed, Silene tatarinowii Regel-Melandrium tatarinwiii (Regel) Tsui., duck kidney ginseng, little Herba Platantherae Japonicae。[source] medical material Ji Yuan: for the herb that orchid uvula lip is blue。[nature and flavor] are sweet；Flat；Nontoxic。[return through] lung；Kidney channel。[function cures mainly] tonifying the lung is reinforced the kidney。Main cough and asthma；Lumbago due to renal deficiency；Seminal emission；Dizzy；Body after being ill。[each discussion] " Traditional Chinese Medicine in Sichuan will ": control lumbago due to renal deficiency, cough and asthma and dizzy body soft。[extracts] " China's book on Chinese herbal medicine "
Partition in Fructus Juglandis: [another name] Semen Juglandis clothing, cracker, Semen Juglandis every, Semen Juglandis every。[nature and flavor] are bitter；Puckery；Property is put down。[return through] spleen；Kidney channel。[function cures mainly] arresting seminal emission reducing urination；Hemostasis leukorrhagia stopping；Antidiarrheal dysentery。Main seminal emission lingering diarrhea；Frequent urination and enuresis；Metrorrhagia；Leukorrhagia, has loose bowels；Dysentery。[each discussion] 1. " book on Chinese herbal medicine is new again ": spleen benefiting and strengthen kidney。2. Chen Nian ancestral: astringent therapy vital essence。3. " Tianjin Chinese herbal medicine ": astringent or styptic treatment for spontaneous sweating convergence。Control seminal emission, frequent micturition, leukorrhagia。[extracts] " China's book on Chinese herbal medicine "
Radix eriosematis chinensis: [another name] mountain Pueraria lobota, energetically cattle, Cor Gigeriae Galli potato, Caput Gallus domesticus, yam bean, mountain stilbene potato, Herba Violae mundae。[source] medical material Ji Yuan: for the tuber of leguminous plant Radix eriosematis chinensis。[nature and flavor] are sweet；Flat。[return through] lung；Large intestine；Liver Channel。[function cures mainly] removing heat from the lung and dissipating phlegm；Promoting the production of body fluid to quench thirst；Detumescence。Main cough due to lung-heat；Lung abscess；Heating excessive thirst；Dysentery；Hydrocele of testis, food stagnation does not disappear；Treating swelling and pain by traumatic injury。[each discussion] be " the SHENGCAO property of medicine is standby to be wanted " 1.: relieving cough and resolving phlegm, lung moistening nourishing kidney。2. " Guangxi Chinese medicinal herbal ": clear away heart-fire lung, promoting the production of body fluid to quench thirst。Control cough due to lung-heat, abdominal pain due to damp-heat。[extracts] " China's book on Chinese herbal medicine "
Herba Salviae Chinensis: [another name] Herba Salviae Chinensis, five phoenixes flower, little Radix Salviae Miltiorrhizae, below the moon red, Herba Salviae Chinensis, Zi Danhua, Herba Scutellariae Barbatae。[source] medical material Ji Yuan: for the herb of labiate Salvia chinensis。[nature and flavor] acrid in the mouth；Bitter；Cold nature。[return through] returns liver；Spleen channel。[function cures mainly] blood circulation promoting and blood stasis dispelling；Clearing away heat-damp and promoting diuresis；Mass dissipating and swelling eliminating。Main menoxenia；Dysmenorrhea；Amenorrhea；Metrorrhagia, has blood in stool；Jaundice due to damp-heat；Hot toxic-heat and blood stasis；Drench pain；Leukorrhagia；Rheumatic ostalgia；Scrofula；Skin ulcer swells；Acute mastitis；Herpes zoster；Leprosy；Traumatic injury wound is swollen。[extracts] " China's book on Chinese herbal medicine "
Fluffy: [another name] covers basin, mound, the moon, cuts field, the cold certain kind of berries, cold。[source] medical material Ji Yuan: for the fruit of rosaceous plant Rubus tephrodes。[nature and flavor] sweet acid；Temperature。[return through] liver, kidney channel。[function cures mainly] the kidney invigorating and essence nourishing, reducing urination。Main polyuria, sexual impotence, sterile, early whitening of beard and hair, carbuncle。[each discussion] 1. " herbal classic ": main settling five organs, benefit vital essence, long the moon order heavily fortified point, and strong will times power has son。2. " medical center bun is wanted ": tonifying the lung, cold removing。[extracts] " China's book on Chinese herbal medicine "
Spongilla: [another name] spongilla, beggar。[source] medical material Ji Yuan: for the dry colony of the letter bone crisp spongilla sp of Spongiidae animal。[nature and flavor] sweet in the mouth；Warm in nature。[return through] kidney channel。[function cures mainly] reinforcing the kidney and supporting YANG；Controlling nocturnal emission with astringent drugs reducing urination。Main sexual impotence；Seminal emission；Nebulousurine；Deficiency and coldness leukorrhagia；Incontinence of urine；Scrotum pruritus due to damp pathogen。[each discussion] " detailed outline ": the secret essence in Yiyang, treats true strength void exhausted, impotence, seminal emission, the heeltap, and nebulousurine is fat such as, incontinence of urine, pruritus due to damp pathogen under capsule, woman's YIN-cold cold belt, enters ball and dissipates and sit soup use。[extracts] " China's book on Chinese herbal medicine "
Rhizoma Ginseng: [another name] ginseng reed, Rhizoma Panacis Japonici。[source] medical material Ji Yuan: want stem for Araliaceae Radix Ginseng。[nature and flavor] sweet in the mouth；Micro-hardship；Warm in nature。[return through] returns stomach；Spleen；Lung meridian。[function cures mainly] ascending up spleen-Qi and Yang。Main sinking of QI due to deficiency of the spleen；Chronic diarrhea；Proctoptosis。[each discussion] 2. " book on Chinese herbal medicine justice ": all have loose bowels with the passing of time, yang-energy sink, and ginseng reed adds and answers in medication, quite powerful, if dysentery pus and blood, and warm clear, then can not rise also。[extracts] " China's book on Chinese herbal medicine "
Rhizoma cimicifugae simplicis: [source] medical material Ji Yuan: for the rhizome of ranunculaceae plant cimicifuga simplex Wormsk。[nature and flavor] Gan Xin；Micro-hardship；It is slightly cold。[return through] lung；Spleen；Large intestine channel。[function cures mainly] delivers rash；Heat-clearing and toxic substances removing；Rise and lift clear sun。Main anemopyretic cold；Infantile measles；Maculopapulae due to toxic heat；Laryngopharynx swelling and pain；Carbuncle skin infection；YANG MING headache；And chronic diarrhea proctoptosis；Woman's metrorrhagia；Leucorrhea。[each discussion] " will planted by Tianmu Mountains of Zhejiang Province medicine ": dissipate wind, removing toxic substances, yang invigorating。Rash。Control seasonal epidemic pathogens epidemic disease, YANG MING headache, laryngalgia, macule, wind heat skin infection, chronic diarrhea proctoptosis, woman's metrorrhagia and leukorrhagia, infantile measles。Consumption eight points is to two money。[extracts] " China's book on Chinese herbal medicine "
Folium Phaseoli: [another name] Semen Phaseoli leaves of pulse plants, the Semen Phaseoli leaves of pulse plants, Semen Phaseoli leaf。[source] medical material Ji Yuan: for the leaf of leguminous plant Semen Phaseoli or Semen Phaseoli。[nature and flavor] sweet in the mouth；Acid；Puckery；Property is put down。[return through] liver；Kidney；Stomach warp。[function cures mainly] tonifying the kidney to reduce urination；Improving eyesight；Quench the thirst。Main frequent micturition；Liver-heat order is stuck with paste；Restlessness and thirst。[each discussion] " Mingyi Bielu ": main only frequent micturition, goes dysphoria with smothery sensation。[extracts] " China's book on Chinese herbal medicine "
Herba Potentillae Fragarioidis: [another name] strawberry cinquefoil root, Folium Rhododendri Daurici, hair monkey, the torsion of soft stalk Serpentis, warp such as grass。[source] medical material Ji Yuan: for the herb of rosaceous plant strawberry cinquefoil root。[nature and flavor] are sweet；Temperature。[return through] lung；Spleen channel。[function cures mainly] blood circulation promoting and blood stasis dispelling, replenishing YIN and removing heat。Main hernia, an emaciation due to blood disorder。[each discussion] " Shaanxi medical herbs ": gas in benefit, nourishing YIN is empty。Control hernia and an emaciation due to blood disorder。[extracts] " China's book on Chinese herbal medicine "
Strobilanthes sarcorrhizus Cling: [another name] soil Radix Pseudostellariae, meat root Acanthaceous indigo。[source] medical material Ji Yuan: for root or the herb of acanthaceous plant Strobilanthes sarcorrhizus Cling。[nature and flavor] sweet in the mouth；Micro-hardship；Cool in nature。[return through] returns kidney；Stomach warp。[function cures mainly] tonifying kidney and nourishing yin；Heat-clearing and toxic substances removing。Main kidney tiger lumbago；Tiger pyretic toothache；Hepatitis；Furuncle furuncle and phyma。[each discussion] " Xinhua's book on Chinese herbal medicine outline ": root is used for lumbago due to renal deficiency。[extracts] " China's book on Chinese herbal medicine "
Rhizoma panacis majoris: [another name] pearl ginseng, Pestalotia funera, pimple seven, Rhizoma Panacis Majoris, dish seven, wild Radix Notoginseng, belt segment Radix Notoginseng。[source] medical material Ji Yuan: for the rhizome of Araliaceae Rhizoma panacis majoris。[nature and flavor] bitter in the mouth；Sweet；Cold in nature。[function cures mainly] clearing away heat and nourishing YIN；Dissipating blood stasis stops blooding；Reducing swelling and alleviating pain。Main calentura excessive thirst；Deficiency of YIN cough due to lung-heat；Hemoptysis；Spit blood；Epistaxis；Have blood in stool；Hematuria；Metrorrhagia；Traumatic hemorrhage；Traumatic injury wound is swollen；Rheumatic arthralgia；Stomachache；Menoxenia；Acute toothache；Laryngopharynx swelling and pain；Sore and toxic。[each discussion] 1. " Traditional Chinese Medicine in Sichuan will ": dissipating blood stasis, hemostasis, analgesic therapy。Controlling injury from falling down, consumptive disease wound is spitted blood, metrorrhagia hematochezia。2. " Shaanxi Chinese herbal medicine ": relieving convulsion relieve dizziness, high fever, infantile convulsions, epilepsy, etc., except rheumatism, stomach invigorating of regulating the flow of vital energy, pain relieving。Control infantile convulsion, rheumatic arthritis, gastropathy, toxic swelling malignant boil。[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Habenria petelotii Gagnep. 15～25 parts, Radix Habenariae Delavayi 10～20 parts, Herba Ainsliaeae ovovatae 5～15 parts, Plantula Brassicae chinensis 15～30 parts, Radix potentillae anserinae 25～35 parts, the Yunnan five tastes 20～30 parts, Herba platantherae minoris 15～30 parts, Partition in Fructus Juglandis 15～25 parts, Radix eriosematis chinensis 15～30 parts, Herba Salviae Chinensis 20～30 parts, fluffy 15～25 parts, Spongilla 30～40 parts, Rhizoma Ginseng 15～30 parts, Rhizoma cimicifugae simplicis 5～15 parts, Folium Phaseoli 25～35 parts, Herba Potentillae Fragarioidis 15～30 parts, Strobilanthes sarcorrhizus Cling 15～25 parts and Rhizoma panacis majoris 5～15 parts。
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Habenria petelotii Gagnep. 20～25 parts, Radix Habenariae Delavayi 15～20 parts, Herba Ainsliaeae ovovatae 5～10 parts, Plantula Brassicae chinensis 20～25 parts, Radix potentillae anserinae 30～35 parts, the Yunnan five tastes 25～30 parts, Herba platantherae minoris 15～20 parts, Partition in Fructus Juglandis 15～20 parts, Radix eriosematis chinensis 20～25 parts, Herba Salviae Chinensis 25～30 parts, fluffy 15～20 parts, Spongilla 30～35 parts, Rhizoma Ginseng 15～20 parts, Rhizoma cimicifugae simplicis 5～10 parts, Folium Phaseoli 25～30 parts, Herba Potentillae Fragarioidis 20～25 parts, Strobilanthes sarcorrhizus Cling 15～20 parts and Rhizoma panacis majoris 10～15 parts。
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Habenria petelotii Gagnep. 21 parts, Radix Habenariae Delavayi 18 parts, Herba Ainsliaeae ovovatae 7 parts, Plantula Brassicae chinensis 25 parts, Radix potentillae anserinae 31 parts, the Yunnan five tastes 28 parts, Herba platantherae minoris 16 parts, Partition in Fructus Juglandis 16 parts, Radix eriosematis chinensis 21 parts, Herba Salviae Chinensis 29 parts, fluffy 17 parts, Spongilla 35 parts, Rhizoma Ginseng 16 parts, Rhizoma cimicifugae simplicis 9 parts, Folium Phaseoli 26 parts, Herba Potentillae Fragarioidis 24 parts, Strobilanthes sarcorrhizus Cling 16 parts and Rhizoma panacis majoris 14 parts。
When the dosage form of described Chinese medicine preparation is granule, it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule。
When the dosage form of described Chinese medicine preparation is capsule, it comprises the following steps:
The first step, Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae and the Yunnan five tastes are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby；It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C；
Second step, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy and Spongilla are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30；
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder；
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule。
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this。
Embodiment 1: granule prepared by the present invention
Take Habenria petelotii Gagnep. 210g, Radix Habenariae Delavayi 180g, Herba Ainsliaeae ovovatae 70g, Plantula Brassicae chinensis 250g, Radix potentillae anserinae 310g, Yunnan five tastes 280g, Herba platantherae minoris 160g, Partition in Fructus Juglandis 160g, Radix eriosematis chinensis 210g, Herba Salviae Chinensis 290g, fluffy 170g, Spongilla 350g, Rhizoma Ginseng 160g, Rhizoma cimicifugae simplicis 90g, Folium Phaseoli 260g, Herba Potentillae Fragarioidis 240g, Strobilanthes sarcorrhizus Cling 160g and Rhizoma panacis majoris 140g。
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85% relative to 5 times of mixture, heat to boiling reflux 5 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.08Mpa is the mastic of 1.05, spray drying, the inlet temperature of spray dryer 165 DEG C, leaving air temp 85 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, make granule, dries in 45 DEG C, it is thus achieved that granule。
Embodiment 2: capsule prepared by the present invention
Take Habenria petelotii Gagnep. 240g, Radix Habenariae Delavayi 160g, Herba Ainsliaeae ovovatae 90g, Plantula Brassicae chinensis 220g, Radix potentillae anserinae 340g, Yunnan five tastes 270g, Herba platantherae minoris 180g, Partition in Fructus Juglandis 190g, Radix eriosematis chinensis 230g, Herba Salviae Chinensis 270g, fluffy 190g, Spongilla 320g, Rhizoma Ginseng 180g, Rhizoma cimicifugae simplicis 70g, Folium Phaseoli 290g, Herba Potentillae Fragarioidis 210g, Strobilanthes sarcorrhizus Cling 190g and Rhizoma panacis majoris 120g。
Its preparation method comprises the following steps:
The first step, Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae and the Yunnan five tastes are mixed in described ratio, add the water extraction volatile oil relative to 5 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, standby；It is the clear paste of 1.16 that aqueous extract is separately concentrated into relative density when 60 DEG C；
Second step, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy and Spongilla are mixed in described ratio, add relative to the alcohol reflux that mixture 6 times amount determining alcohol is 85% 4 times, each 3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times amount water, boil 8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28；
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 65 DEG C of reduced vacuum dry, and get dry extract powder；
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, adding 7 weight portion carboxymethyl starch sodium, 36 weight starch mix homogeneously, adding 190 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 weight portion magnesium stearate, be then charged in gelatine capsule。
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20-30g, carries out acute toxicity test。Mice is randomly divided into two groups, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.67g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.35 crude drugs/kg), and matched group gives normal saline, within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll。Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal。Granule LD50 > 43.35 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 86.7 crude drugs/kg/ day。The Chinese medicine clinical application amount of the present invention be 8.27g crude drug/day/people, adult body weight in 60KG, average dosage is 0.138g crude drug/kg/ day。By weighing machine: 628 times that the dosis tolerata of the Chinese medicine of mice (average weight with 25g) the oral administration gavage present invention is quantity。Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety。
Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often group 20) by 13.27,24.39 and 44.16g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, Organs of Mice is all without substantially changing。Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety。
Clinical data:
Case selection: all 136 example cases derive from this Out-patient Department and the diabetes insipidus patient being in hospital。Above patient is randomly divided into two groups, treatment group and each 68 examples of matched group。In treatment group 68 example, male 44 examples, female 24 example；Age 14-67 year；Course of disease 3-45d；Central diabetes insipidus 37 example, nephrogenic diabetes insipidus 31 example。In matched group 68 example, male 45 examples, female 23 example, age 15-69 year；Course of disease 3-42d；Central diabetes insipidus 36 example, nephrogenic diabetes insipidus 32 example。Through statistical procedures, treatment group and matched group no significant difference (P≤0.01) in age, the course of disease, the state of an illness and clinical symptoms, there is comparability。
Diagnostic criteria: 1, excessive thirst, polydipsia, polyuria, urinary volume for twenty four hours 5-10L or more。It is secondary to wound, inflammation and tumor person, is respectively arranged with the performance of its protopathy。2, obvious dehydration, performance xerostomia, xerosis cutis, antiperspirant are few, constipation。3, specific gravity of urine < 1.006 (partial diabetis insipituses < 1.012)。4, vassopressin stimulation test (as prohibited drink, hypertonic saline test) can not make urine volume substantially reduce, it is impossible to makes the significantly raised (proportion < 1.010 or osmotic pressure of urine < 300mmol/L of specific gravity of urine；Partial diabetis insipitus specific gravity of urine up to 1.016, osmotic pressure of urine > 300mmol/L；And after injecting vassopressin, urine volume significantly reduces, proportion rises。
Therapeutic Method:
Matched group: hydrochlorothiazide tablet 25mg/ time, every day 3 times, oral；Carbamazepine Tablets 0.2g/ time, every day 3 times, oral；Every day can be reduced to 2 times or 1 time in the treatment according to the clinical efficacy situation of patient；Secondary diabetes insipidus patient, answers Cure the Primary Disease；Within 1 week, it is a course for the treatment of, treats 4 courses for the treatment of。
Treatment group: on treatment of control group basis, simultaneously oral Chinese medicine embodiment 1 granule of the present invention, each 20g, every day 3 times；Within 1 week, it is a course for the treatment of, treats 4 courses for the treatment of。
Curative effect judging standard: (1) cures: the clinical symptom disappearance such as excessive thirst, polydipsia, polyuria, urine volume, specific gravity of urine, osmotic pressure of urine are normal。(2) taking a turn for the better: thirsty drinking-water substantially alleviates, hypourocrinia, specific gravity of urine is through being everlasting more than 1.010, and osmotic pressure of urine is higher than 300mmol/L。(3) invalid: the clinical symptoms such as excessive thirst, polydipsia, polyuria are not apparent from alleviating or increasing the weight of, and urine volume, specific gravity of urine, osmotic pressure of urine are still abnormal。
Therapeutic outcome: two groups treat 4 weeks respectively after, statistical result is referring to table 1 and table 2。
Clinical efficacy comparison (unit: example) after treating respectively 4 weeks organized by 1 liang of table
| Group | Number of cases | Cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 68 | 45 | 20 | 3 | 65 (95.59%) |
| Matched group | 68 | 31 | 26 | 11 | 57 (83.82%) |
As it can be seen from table 1 treatment group adopts the Chinese medicine of the present invention, coordinate western medical treatment diabetes insipidus, relative to matched group, on therapeutic effect, have and be markedly improved。
2 liang of table is organized healing number and time after treating 4 weeks respectively and is compared (unit: example/%)
| Group | Number of cases | Medication 2 weeks | Medication 3 weeks | Medication 4 weeks |
| Treatment group | 45 | 18 (26.47%) | 33 (48.53%) | 45 (66.18%) |
| Matched group | 31 | 10 (14.71%) | 19 (27.94%) | 31 (45.59%) |
From table 2 it can be seen that treatment group adopts the Chinese medicine of the present invention, coordinate western medical treatment diabetes insipidus, relative to matched group, not only better efficacy, takes effect also faster。
Relapse rate is added up: the 31 of 45 and the matched group healing that treatment group is cured are followed up a case by regular visits to 6 months respectively, and result is added up, and treatment group is without recurrence, and relapse rate is 0%；Matched group, recurs 4 people, relapse rate 12.9%。
Untoward reaction: matched group 68 example patient, in therapeutic process, there is Nausea and vomiting in 6 examples, and muscle spasm occur in 2 examples, and blurred vision occur in 3 examples, and hypokalemia occurs in 1 example, do not find other untoward reaction。Treatment group 68 example patient, in therapeutic process, does not all find renal function injury or other untoward reaction。
Concrete case: Wu, man, 53 years old, patient's frequent micturition before two weeks, urine volume was surged, thirsty hard to bear, and drinking-water is not understood inquiring and sought medical advice。Clear urine in large amounts, every day 15 times-20 times, total volume of urine is about 10L。Accompany thirsty, polydipsia, poor appetite, sleep poor, constipation, within 3 days, do not solve。Red tongue, the few weary Tianjin of tongue, stringy,thready and rapid pulse。Have urine examined proportion 1.002, looks into head B-sonography and has no tumor。Tcm diagnosis: quench one's thirst, doctor trained in Western medicine is diagnosed as diabetes insipidus (central)。Take hydrochlorothiazide 25mg/ time, carbamazepine 0.2g/ time, every day 3 times, oral, the granule of oral inventive embodiments 1, each 20g, every day 3 times simultaneously。After taking 1 week, thirsty drinking-water substantially alleviates, hypourocrinia, and specific gravity of urine is through being everlasting more than 1.010, and every day, urine was measured at about 2500ml-4000ml；Treating 2 weeks, the clinical symptom disappearance such as excessive thirst, polydipsia, polyuria, urine volume, specific gravity of urine, osmotic pressure of urine are normal, clinical cure, follow up a case by regular visits to 6 months without recurrence。
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement or the new method that limit other forms。Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status。But, all modifications or transformation belong to the right of reservation based on new product of the present invention。
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above。But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention。
Claims (8)
1. the Chinese medicine preparation treating diabetes insipidus, it is characterized in that, described Chinese medicine preparation includes following raw medicinal material: Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae, the Yunnan five tastes, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy, Spongilla, Rhizoma Ginseng, Rhizoma cimicifugae simplicis, Folium Phaseoli, Herba Potentillae Fragarioidis, Strobilanthes sarcorrhizus Cling and Rhizoma panacis majoris。
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Habenria petelotii Gagnep. 15～25 parts, Radix Habenariae Delavayi 10～20 parts, Herba Ainsliaeae ovovatae 5～15 parts, Plantula Brassicae chinensis 15～30 parts, Radix potentillae anserinae 25～35 parts, the Yunnan five tastes 20～30 parts, Herba platantherae minoris 15～30 parts, Partition in Fructus Juglandis 15～25 parts, Radix eriosematis chinensis 15～30 parts, Herba Salviae Chinensis 20～30 parts, fluffy 15～25 parts, Spongilla 30～40 parts, Rhizoma Ginseng 15～30 parts, Rhizoma cimicifugae simplicis 5～15 parts, Folium Phaseoli 25～35 parts, Herba Potentillae Fragarioidis 15～30 parts, Strobilanthes sarcorrhizus Cling 15～25 parts and Rhizoma panacis majoris 5～15 parts。
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Habenria petelotii Gagnep. 20～25 parts, Radix Habenariae Delavayi 15～20 parts, Herba Ainsliaeae ovovatae 5～10 parts, Plantula Brassicae chinensis 20～25 parts, Radix potentillae anserinae 30～35 parts, the Yunnan five tastes 25～30 parts, Herba platantherae minoris 15～20 parts, Partition in Fructus Juglandis 15～20 parts, Radix eriosematis chinensis 20～25 parts, Herba Salviae Chinensis 25～30 parts, fluffy 15～20 parts, Spongilla 30～35 parts, Rhizoma Ginseng 15～20 parts, Rhizoma cimicifugae simplicis 5～10 parts, Folium Phaseoli 25～30 parts, Herba Potentillae Fragarioidis 20～25 parts, Strobilanthes sarcorrhizus Cling 15～20 parts and Rhizoma panacis majoris 10～15 parts。
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Habenria petelotii Gagnep. 21 parts, Radix Habenariae Delavayi 18 parts, Herba Ainsliaeae ovovatae 7 parts, Plantula Brassicae chinensis 25 parts, Radix potentillae anserinae 31 parts, the Yunnan five tastes 28 parts, Herba platantherae minoris 16 parts, Partition in Fructus Juglandis 16 parts, Radix eriosematis chinensis 21 parts, Herba Salviae Chinensis 29 parts, fluffy 17 parts, Spongilla 35 parts, Rhizoma Ginseng 16 parts, Rhizoma cimicifugae simplicis 9 parts, Folium Phaseoli 26 parts, Herba Potentillae Fragarioidis 24 parts, Strobilanthes sarcorrhizus Cling 16 parts and Rhizoma panacis majoris 14 parts。
5. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule。
6. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae and the Yunnan five tastes are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby；It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C；
Second step, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy and Spongilla are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30；
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder；
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule。
7. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is granule, and it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule。
8. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Habenria petelotii Gagnep., Radix Habenariae Delavayi, Herba Ainsliaeae ovovatae, Plantula Brassicae chinensis, Radix potentillae anserinae and the Yunnan five tastes are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby；It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C；
Second step, Herba platantherae minoris, Partition in Fructus Juglandis, Radix eriosematis chinensis, Herba Salviae Chinensis, fluffy and Spongilla are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30；
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder；
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule。
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| CN106492099A (en) * | 2016-11-30 | 2017-03-15 | 四川旭华制药有限公司 | A kind of economical fossil pharmaceutical composition |
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| CN101264253A (en) * | 2008-05-08 | 2008-09-17 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating diabetes insipidus and preparation thereof |
| CN102949734A (en) * | 2012-09-18 | 2013-03-06 | 王玉云 | Traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and preparation method thereof |
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| CN101264253A (en) * | 2008-05-08 | 2008-09-17 | 北京天科仁祥医药科技有限公司 | Chinese medicinal composition for treating diabetes insipidus and preparation thereof |
| CN102949734A (en) * | 2012-09-18 | 2013-03-06 | 王玉云 | Traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106492099A (en) * | 2016-11-30 | 2017-03-15 | 四川旭华制药有限公司 | A kind of economical fossil pharmaceutical composition |
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