CN105434963A - Traditional Chinese medicine preparation for treating tuberculosis of bone and joint and preparation method for traditional Chinese medicine preparation - Google Patents

Traditional Chinese medicine preparation for treating tuberculosis of bone and joint and preparation method for traditional Chinese medicine preparation Download PDF

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CN105434963A
CN105434963A CN201610003994.1A CN201610003994A CN105434963A CN 105434963 A CN105434963 A CN 105434963A CN 201610003994 A CN201610003994 A CN 201610003994A CN 105434963 A CN105434963 A CN 105434963A
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parts
radix
chinese medicine
herba
mastic
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谢文贵
高鹏飞
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention provides a traditional Chinese medicine preparation for treating tuberculosis of bone and joint and a preparation method for the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following raw materials: latouchea fokiensis, common jasmin orange, diospyros rhombifolia, loureiro clematis herb, orchidaceae pecteilis, dioscorea glabra roxb., nude pronephrium rhizome, balsampear seed, root of farges figwort, manyinflorescenced sweetvetch root, gypsum, gelidium amansii lamx., glabrous torenia herb, red nanmu bark, bilobate grewia, common cowpea root, ficus esquiroliana, seed of foxtail millet, procumbent gynura and longcalyx chonemorpha stem. The traditional Chinese medicine preparation provided by the invention has a better treatment effect on tuberculosis of bone and joint by matching with the traditional method of Western medicine, has no toxic and side effects and adverse reactions, and has a fast effect and a simple preparation process.

Description

A kind of Chinese medicine preparation for the treatment of tuberculosis of bone and joint and preparation method thereof
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation for the treatment of tuberculosis of bone and joint and preparation method thereof.
Background technology
Tuberculosis of bone and joint child and juvenile onset rate the highest, but adult also can occur.What occur in spinal column accounts for 50%, and weight-bearing joints is as hip joint, and knee joint, ankle joint etc. are also more, upper limb as shoulder, elbow and carpal joint less.Morbidity slowly, can have low grade fever in afternoon, affected part pain, tenderness, kowtows pain and muscle spasm, and joint motion is limited.Slightly not red, the not hot abscess of late origin, is called cold abscess; After ulceration, forming sinus tract, can there is ankylosis in secondary mixed infection.Active pathological process period erythrocyte sedimentation rate speeds, and in leukocyte differential count, lymph corpuscle increases; May find tubercule bacillus in pus, pathologic finding contributes to making a definite diagnosis.The visible osteoporosis of X-ray examination and bone destruction, intervertebral space or joint space is narrow and abscess shade.The key for the treatment of is early stage diagnosis and treatment, comprises and having a rest and local braking, have additional nutrients and apply antituberculotics, and abscess puncture evacuation of pus also injects antituberculotics; Row clearance of focal lesion, arthrectomy, arthrodesis and spinal fusion if desired.
Tuberculosis of bone and joint belongs in Chinese medicine " bone tuberculosis ", the category of " tuberculosis of bone and joint ".The paathogenic factor of the tuberculosis of bone and joint is congenital defect, and skeleton is tender, or damages to some extent, causes disharmony between QI and blood, the turbid cohesion of wind and cold expectorant, stays in skeleton, namely first close deficiency, and deficiency of the kidney arm sky is disease basis, the turbid cohesion of expectorant, wind and cold invasion and attack, or damage is the mark of disease to some extent.In the whole course of disease, its begin for cold, it sees for heat, namely have congenital defect, the void of deficiency of the kidney bone sky, have again the reality of the turbid cohesion of disharmony between QI and blood, expectorant; When suppuration, not only cold transformation is heat, the moon transfers sun to, and deficiency of kidney yin is more obvious; The cloudy hyperactivity of fire that loses can become; Sick pus dripping urine endlessly for a long time, the large wound of QI and blood, QI and blood deficiency are visible.Tuberculosis of bone and joint is the secondary affection of whole body tuberculosis, and treatment must have organic conception, emphasizes the Comprehensive Treatment that whole body is laid equal stress on local.Implement the principle of early diagnosis, early treatment, with Shorten the Treatment Process, prevent deformity, reduce invalid, reduce relapse rate.By rest, nutrition and braking, differentiation of tcm, the utilization of antitubercular agent, operative treatment reaches lays equal stress on to the entire and part of chronic debilitating tuberculosis of bone and joint disease, and the combination of inner and outside, kills tubercule bacillus, repair the object of slough, and alleviate the toxic and side effects of antitubercular agent.
Summary of the invention
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of determined curative effect and Chinese medicine preparation of the little treatment tuberculosis of bone and joint of toxic action and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of tuberculosis of bone and joint, described Chinese medicine preparation comprises following raw medicinal material: Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Bai Diehua, Red Hill medicine, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum, Eucheuma gelatinosum, Herba Toreniae Glabrae, Cortex Machili Thunbergii Radicis, Radix grewiae bilobae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Radix limonii sinensis 15 ~ 25 parts, Radix Buddlejae Butterflybush 10 ~ 20 parts, Radix seu Ramulus Diospyroris rhombifoliae 30 ~ 40 parts, Herba Clematidis loureirianae 15 ~ 30 parts, white butterfly spends 30 ~ 40 parts, Red Hill medicine 15 ~ 30 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5 ~ 15 parts, Semen Momordicae Charantiae 20 ~ 35 parts, Radix Scrophulariae fargesii 15 ~ 25 parts, Radix Hedysari 25 ~ 35 parts, Selenitum 10 ~ 25 parts, Eucheuma gelatinosum 5 ~ 15 parts, Herba Toreniae Glabrae 15 ~ 25 parts, Cortex Machili Thunbergii Radicis 20 ~ 35 parts, Radix grewiae bilobae 20 ~ 30 parts, Radix vignae sinensis 5 ~ 15 parts, Ficus fulva Reinw. 10 ~ 25 parts, Semen Setariae italicae 15 ~ 25 parts, Herba Gynurae procumbentis 20 ~ 30 parts and Caulis Chonemorphae Megacalycis 25 ~ 35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Radix limonii sinensis 20 ~ 25 parts, Radix Buddlejae Butterflybush 15 ~ 20 parts, Radix seu Ramulus Diospyroris rhombifoliae 35 ~ 40 parts, Herba Clematidis loureirianae 20 ~ 25 parts, white butterfly spends 30 ~ 35 parts, Red Hill medicine 25 ~ 30 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 10 ~ 15 parts, Semen Momordicae Charantiae 25 ~ 30 parts, Radix Scrophulariae fargesii 15 ~ 20 parts, Radix Hedysari 25 ~ 30 parts, Selenitum 20 ~ 25 parts, Eucheuma gelatinosum 5 ~ 10 parts, Herba Toreniae Glabrae 15 ~ 20 parts, Cortex Machili Thunbergii Radicis 25 ~ 30 parts, Radix grewiae bilobae 20 ~ 25 parts, Radix vignae sinensis 5 ~ 10 parts, Ficus fulva Reinw. 15 ~ 20 parts, Semen Setariae italicae 20 ~ 25 parts, Herba Gynurae procumbentis 25 ~ 30 parts and Caulis Chonemorphae Megacalycis 30 ~ 35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Radix limonii sinensis 21 parts, Radix Buddlejae Butterflybush 18 parts, Radix seu Ramulus Diospyroris rhombifoliae 36 parts, Herba Clematidis loureirianae 21 parts, white butterfly spends 32 parts, Red Hill medicine 28 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12 parts, Semen Momordicae Charantiae 26 parts, Radix Scrophulariae fargesii 16 parts, Radix Hedysari 29 parts, Selenitum 22 parts, Eucheuma gelatinosum 10 parts, Herba Toreniae Glabrae 16 parts, Cortex Machili Thunbergii Radicis 28 parts, Radix grewiae bilobae 22 parts, Radix vignae sinensis 10 parts, Ficus fulva Reinw. 16 parts, Semen Setariae italicae 24 parts, Herba Gynurae procumbentis 26 parts and Caulis Chonemorphae Megacalycis 35 parts.
When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described mastic compound particles, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, white butterfly flower and Red Hill medicine are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum and Herba Toreniae Glabrae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
Beneficial effect of the present invention: Chinese medicine preparation of the present invention, coordinate doctor trained in Western medicine traditional treatment methods tuberculosis of bone and joint, therapeutic effect is better, and have no side effect and untoward reaction, instant effect, preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of tuberculosis of bone and joint, Chinese medicine preparation comprises following raw medicinal material: Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Bai Diehua, Red Hill medicine, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum, Eucheuma gelatinosum, Herba Toreniae Glabrae, Cortex Machili Thunbergii Radicis, Radix grewiae bilobae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis.
The pharmacology of various raw medicinal material is as follows:
Radix limonii sinensis: [another name] mother honker leaf, red shrimp toad leaf.[source] medical material Ji Yuan: be the herb of gentianaceae plant Radix limonii sinensis.[nature and flavor] are bitter; Pungent; Cold in nature.[return through] lung; Liver; Large intestine channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Clearing and antitussive.Blood stasis mass in the abdomen in main abdomen; Epersalgia cough.[extracts] " China's book on Chinese herbal medicine "
Radix Buddlejae Butterflybush: [another name] MANSHANXIANG.[source] medical material Ji Yuan: be root, the leaf of Pittosporaceae plant platform Qionghai paulownia.[function cures mainly] promoting blood circulation and detumescence, removing toxic substances dysentery relieving.Main traumatic injury, dysentery.[each discussion] 1. " conventional glossary of Herbs and Drugs among the people ": QI and blood regulating, logical menstruation.2. " Traditional Chinese Medicine in Sichuan will ": activating blood circulation.[extracts] " China's book on Chinese herbal medicine "
Radix seu Ramulus Diospyroris rhombifoliae: [another name] milk Fructus Kaki, Flos Caryophylli Fructus Kaki, have month in and month out, branch Fructus Kaki, fourth show Lee, fist Lee, the large old nurse of tripe, top Buddhist monk, glutinous rice thorn, bitter Lee, monkey be always sub.[source] medical material Ji Yuan: be root or the branch of Ebenaceae plant Radix seu Ramulus Diospyroris rhombifoliae.[nature and flavor] are bitter; Property is put down.[return through] Liver Channel.[function cures mainly] clearing away damp-heat; Profit liver and gall; Blood circulation promoting and blood stasis dispelling.Main acute icterohepatitis; Liver cirrhosis; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba Clematidis loureirianae: [another name] wild Caulis Akebiae, Caulis Clematidis Chrysocomae, ferrum foot Wheeling, RADIX ANEMONAE.[source] medical material Ji Yuan: be rattan or the root of ranunculaceae plant gold pig-iron line.[nature and flavor] sweet in the mouth; Light; Property is put down.[return through] returns liver; Kidney; Urinary bladder channel.[function cures mainly] clearing away heat and promoting diuresis; Promoting blood circulation to restore menstrual flow; Expelling wind and removing dampness.Main dysuria; Edema; Damp-heat gonorrhoea; Rheumatic arthralgia; Traumatic injury; Scorching on wind-fire; Eye red pain; Amenorrhea; Mange.[extracts] " China's book on Chinese herbal medicine "
White butterfly flower: [another name] Radix Pecteilis susannae, gentle grass, native Rhizoma Polygonati Odorati, ovum gallinaceum ginseng, cock flower, Radix Satyrii nepalensis, spend ginseng, pairing umbrella, Herba Microtis taiwanianae in vain.[source] medical material Ji Yuan: be the tuber that orchid tap is blue.[nature and flavor] sweet in the mouth; Slightly warm in nature.[function cures mainly] kidney invigorating and YANG supporting; Soothing the liver cold expelling.Main lumbago due to renal deficiency; Sexual impotence; Seminal emission; Colic of cold type.[extracts] " China's book on Chinese herbal medicine "
Red Hill medicine: [another name] glues potato, Herba Begoniae Laciniatae, wild Radix Ipomoeae, Cornu Caprae seu Ovis Rhizoma Dioscoreae, careless Bashan Mountain medicine, bitter Rhizoma Dioscoreae, dish potato.[source] medical material Ji Yuan: be the tuber of Dioscoreaceae Plant Light leaf Rhizoma Dioscoreae.[nature and flavor] are bitter; Micro-pungent; Flat.[function cures mainly] removing toxic substances dysentery relieving; Promoting blood circulation to restore menstrual flow; Hemostasis.Main dysentery; Rheumatic arthralgia; Lumbar muscle strain; Menoxenia; Metrorrhagia; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching: [another name] loose blood connects.[source] medical material Ji Yuan: be the rhizome of Thelypteridaceae plant many plumages crescent Herba pteridii latiusculi.[nature and flavor] tremble with fear; Bitter; Puckery.[return through] heart; Stomach warp.[function cures mainly] dredge the meridian passage; Regulating QI to expel dampness.Main menoxenia; Dysentery; Energy-stagnation stomachache; Impairment caused by overstrain pain.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Semen Momordicae Charantiae: [source] medical material Ji Yuan: be the seed of cucurbitaceous plant Fructus Momordicae charantiae.[nature and flavor] bitter in the mouth; Sweet; Warm in nature.[function cures mainly] warming and recuperating the kidney-YANG.Main insufficiency of kidney-YANG; Frequent micturition; The enuresis; Seminal emission; Sexual impotence.[each discussion] Compendium of Material Medica: QI invigorating tonifying YANG.[extracts] " China's book on Chinese herbal medicine "
Radix Scrophulariae fargesii: [another name] Hubei Province Radix Scrophulariae.[source] medical material Ji Yuan: be the tuber of goatweed Radix Scrophulariae fargesii.[nature and flavor] bitter in the mouth; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing.Main intestinal is scorching; Dysentery; Sore swollen toxin.[extracts] " China's book on Chinese herbal medicine "
Radix Hedysari: [another name] sweetvetch, black stilbene.[source] this product is the dry root of leguminous plant Hedysarum polybotrys Hand.-Mazz..[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.[extracts] " Chinese Pharmacopoeia "
Selenitum: [another name] lunar profound essence, lunar Selenitum, Taiyi Selenitum, cloudy smart stone, profound diamond stone, kyphosis Selenitum.[source] medical material Ji Yuan: be the crystal of Sulfates Gypsum Fibrosum race mineral gypsum.[nature and flavor] are salty; Cold.[return through] kidney; Spleen; Stomach warp.[function cures mainly] YIN nourishing; Pathogenic fire reducing; Softening the hard mass; Expectorant.Main overabundance of YANG leading to deficiency of YIN; High fever excessive thirst; Wind syndrome of head headache; Conjunctival congestion is hidden from view; Congenital deformity of the tongue; Swollen and rigid tongue; Laryngopharynx swelling and pain; Head sore; Burn due to hot liquid or fire.[each discussion] " Kaibao Bencao ": except air-cooled pathogen arthralgia chiefly caused by damp pathogen, beneficial vital essence, married woman's syndrome of aversion to cold lasting day and night with cold limbs leaks down, and trusted subordinate gathers cold air, only headache, expelling pathogenic factors from muscles.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Eucheuma gelatinosum: [another name] Eucheuma gelatinosum, ox hair Parmelia saxatilis Ach., Ottelia acuminata (Gagnep.) Dandy, Herba Pileae Scriptae.[source] medical material Ji Yuan: be the frond of Gelidiaceae phytobezoar Herba Astragali Sinici, fine, soft fur Eucheuma gelatinosum, pacific gelidium etc.[nature and flavor] are sweet; Salty; Cold; Sliding; Nontoxic.[return through] liver; Lung meridian.[function cures mainly] heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Laxation; Drive ascarid.Main enteritis, diarrhea; Pyelonephritis; Goiter; Tumor; Bleeding hemorrhoids; Chronic constipation; Ascarid is disease early.[each discussion] 1. " daily book on Chinese herbal medicine ": go part of the body cavity above the diaphragm housing the heart and lungs superficial heat.Give the deficiency and coldness of Jiao.2. " book on Chinese herbal medicine is just read ": lung heat clearing portion heat-phlegm, lead wet-heat of intestines, the cards such as the deficiency of YIN is damp and hot, hemorrhoidal bleeding, all can use it.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Herba Toreniae Glabrae: [another name] bluet, water Radix Polygalae, Radix Gentianae, old antidote for snake bites.[source] medical material Ji Yuan: be the herb of goatweed Herba Toreniae glabrae.[nature and flavor] sweet in the mouth; Micro-hardship; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances; Dissipating blood stasis.Main heat syndrome cough; Jaundice; Dysentery; Stranguria with blood; Furunculosis; Serpentis hinders; Traumatic injury.[each discussion] 1. " Nanning City's medicine will ": refreshing and detoxicating, hemostasis and pain-relieving.Treating snakebite, dysentery.2. " catalogue planted by Guizhou medicine ": heat-clearing and toxic substances removing, dampness removing, cough-relieving, blood stasis dispelling.To harness the Yellow River subcutaneous ulcer, stranguria with blood, cough due to pathogenic wind-heat, diarrhoea, furunculosis, traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Cortex Machili Thunbergii Radicis: [source] medical material Ji Yuan: be root bark, the bark of the red nanmu of canella.[nature and flavor] are pungent; Bitter; Temperature.[return through] spleen; Liver; Stomach warp.[function cures mainly] warming middle-JIAO is pleasant; Shu Jing invigorates blood circulation; Reducing swelling and alleviating pain.Main vomiting and diarrhoea; Infantile milk regurgitation; Anorexia lack of appetite; Bruise; Convulsion; Foot is swollen.[each discussion] " will planted by Tianmu Mountains of Zhejiang Province medicine ": control bruise muscle, root or bark are mashed deposited with Sal; Control and vomit and diarrhoea incessantly, bark decocts water clothes; Control convulsion foot swollen, bark decocts soup fumigation and wash method.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Radix grewiae bilobae: [another name] my child fist, sesame candy fruit, stubborn mountain skin, cotton rib, mountain network fiber crops, Canis familiaris L. broom corn millet, string fruit whelp, Testis et Pentis Canis is sub, clamping plate are sub, the moon pearlite layer, Grewia biloba G.Don.[source] medical material Ji Yuan: be the Herb of Tiliaceae plant bilobed grewia.[nature and flavor] are sweet; Bitter; Temperature.[return through] liver; Spleen; Stomach warp.[function cures mainly] invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Main insufficiency of the spleen lack of appetite; Proctoptosis of a specified duration; Infantile malnutrition; Ascariasis; Rheumatic arthralgia; Seminal emission; Metrorrhagia; Leukorrhagia; Uterine prolapse.[each discussion] " conventional glossary of Herbs and Drugs among the people ": strengthening spleen and nourishing blood.Control the weak and women's metrorrhagia and leukorrhagia of children's's infantile malnutrition gas.[extracts] " China's book on Chinese herbal medicine "
Radix vignae sinensis: [source] medical material Ji Yuan: be the root of leguminous plant Semen vignae sinensis.[nature and flavor] are sweet; Flat.[return through] spleen; Stomach warp.[function cures mainly] invigorating the spleen and benefiting QI; Removing food stagnancy; Removing toxic substances.Main weakness of the spleen and stomach; Food stagnation; Leucorrhea; Stranguria with turbid discharge; Hemorrhoidal bleeding; Furuncle.[each discussion] " Chongqing medical herbs ": invigorating the spleen and benefiting QI.Control weakness of the spleen and stomach, leucorrhea nebulousurine, bleeding hemorrhoids.[extracts] " China's book on Chinese herbal medicine "
Ficus fulva Reinw.: [another name] native Cortex Mori, Herba Fici Simplicissimae, Mapo wind, shake wind, crow wind greatly.[source] medical material Ji Yuan: be the root bark of moraceae plants Ficus fulva Reinw..[nature and flavor] are sweet; Property is put down.[function cures mainly] replenishing QI to invigorate the spleen; Expelling wind and removing dampness.Cure mainly the deficiency of vital energy; The prolapse of the uterus; Proctoptosis; Loose stool; Edema; Rheumatic arthralgia.[each discussion] " Xinhua's book on Chinese herbal medicine outline ": root bark: sweet in the mouth, property are flat.There is invigorating the spleen and benefiting QI, effect of promoting blood circulation by removing wind.For deficient qi and blood, uterine prolapse, proctoptosis, rheumatic arthralgia, the disease such as to have loose bowels.[extracts] " China's book on Chinese herbal medicine "
Semen Setariae italicae: [source] medical material Ji Yuan: be the kernel of one of grass fine strain of millet or foxtail millet kind.[nature and flavor] sweet in the mouth; Be slightly cold.[return through] spleen; Stomach warp.[function cures mainly] invigorating the spleen and benefiting QI; Arresting seminal emission antidiarrheal; Inducing diuresis for treating stranguria syndrome.Main insufficiency of the spleen lack of appetite; Dysphoria with smothery sensation; Quench one's thirst; Let out essence; Dysentery; Stranguria.[each discussion] 1. " Mingyi Bielu ": main stomach numbness, hanker quenching one's thirst, stopping leak dysentery, diuresis, QI invigorating invigorating middle warmer.2. " Japan hanako materia medica ": spleen invigorating, control and let out essence.[extracts] " China's book on Chinese herbal medicine "
Herba Gynurae procumbentis: [another name] stone Radix Notoginseng, tree Radix Notoginseng, JIANZHONGXIAO, Leymus chinensis (Trin.) Tzvel. traumatic injury, white leaf traumatic injury.[source] medical material Ji Yuan: for feverfew puts down the herb of sleeping Herba Senecionis Chrysanthemoidis.[nature and flavor] acrid in the mouth; Micro-hardship; Cool in nature.[function cures mainly] dissipating blood stasis; Detumescence; Clearing and antitussive.Main traumatic injury; Rheumatic arthralgia; Pneumonia; Pulmonary tuberculosis; Carbuncle pyogenic infections from tumour or sore.[extracts] " China's book on Chinese herbal medicine "
Caulis Chonemorphae Megacalycis: [another name] large Cortex Eucommiae, Radix seu caulis chonemorphae valvatae, the native Cortex Eucommiae, Radix Seu Caulis Euonymi Yunnanensis, the filamentary silver Cortex Eucommiae, crystal bean jelly seed, Herba Potentillae betonicaefoliae, large Radix seu caulis chonemorphae valvatae.[source] medical material Ji Yuan: be the rattan of the long calyx Chonemorpha eriostylis of apocynaceae plant.[nature and flavor] are pungent; Warm in nature.[return through] lung; Kidney channel.[function cures mainly] dispelling wind and removing obstruction in the collateral; Promoting blood circulation and stopping pain.Main anemofrigid-damp arthralgia; Chills and pain of the waist and kness; Traumatic injury; Traumatic hemorrhage.[each discussion] " choosing of Yunnan Chinese herbal medicine ": dredge the meridian passage, promoting blood circulation and hemostasis, synthetism granulation promoting, blood pressure lowering.Treating rheumatic lumbago and skelalgia, deficiency of the kidney lumbago, hypertension, fracture, traumatic injury.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Radix limonii sinensis 15 ~ 25 parts, Radix Buddlejae Butterflybush 10 ~ 20 parts, Radix seu Ramulus Diospyroris rhombifoliae 30 ~ 40 parts, Herba Clematidis loureirianae 15 ~ 30 parts, white butterfly spends 30 ~ 40 parts, Red Hill medicine 15 ~ 30 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5 ~ 15 parts, Semen Momordicae Charantiae 20 ~ 35 parts, Radix Scrophulariae fargesii 15 ~ 25 parts, Radix Hedysari 25 ~ 35 parts, Selenitum 10 ~ 25 parts, Eucheuma gelatinosum 5 ~ 15 parts, Herba Toreniae Glabrae 15 ~ 25 parts, Cortex Machili Thunbergii Radicis 20 ~ 35 parts, Radix grewiae bilobae 20 ~ 30 parts, Radix vignae sinensis 5 ~ 15 parts, Ficus fulva Reinw. 10 ~ 25 parts, Semen Setariae italicae 15 ~ 25 parts, Herba Gynurae procumbentis 20 ~ 30 parts and Caulis Chonemorphae Megacalycis 25 ~ 35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Radix limonii sinensis 20 ~ 25 parts, Radix Buddlejae Butterflybush 15 ~ 20 parts, Radix seu Ramulus Diospyroris rhombifoliae 35 ~ 40 parts, Herba Clematidis loureirianae 20 ~ 25 parts, white butterfly spends 30 ~ 35 parts, Red Hill medicine 25 ~ 30 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 10 ~ 15 parts, Semen Momordicae Charantiae 25 ~ 30 parts, Radix Scrophulariae fargesii 15 ~ 20 parts, Radix Hedysari 25 ~ 30 parts, Selenitum 20 ~ 25 parts, Eucheuma gelatinosum 5 ~ 10 parts, Herba Toreniae Glabrae 15 ~ 20 parts, Cortex Machili Thunbergii Radicis 25 ~ 30 parts, Radix grewiae bilobae 20 ~ 25 parts, Radix vignae sinensis 5 ~ 10 parts, Ficus fulva Reinw. 15 ~ 20 parts, Semen Setariae italicae 20 ~ 25 parts, Herba Gynurae procumbentis 25 ~ 30 parts and Caulis Chonemorphae Megacalycis 30 ~ 35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Radix limonii sinensis 21 parts, Radix Buddlejae Butterflybush 18 parts, Radix seu Ramulus Diospyroris rhombifoliae 36 parts, Herba Clematidis loureirianae 21 parts, white butterfly spends 32 parts, Red Hill medicine 28 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12 parts, Semen Momordicae Charantiae 26 parts, Radix Scrophulariae fargesii 16 parts, Radix Hedysari 29 parts, Selenitum 22 parts, Eucheuma gelatinosum 10 parts, Herba Toreniae Glabrae 16 parts, Cortex Machili Thunbergii Radicis 28 parts, Radix grewiae bilobae 22 parts, Radix vignae sinensis 10 parts, Ficus fulva Reinw. 16 parts, Semen Setariae italicae 24 parts, Herba Gynurae procumbentis 26 parts and Caulis Chonemorphae Megacalycis 35 parts.
When the dosage form of described Chinese medicine preparation is tablet, it comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described mastic compound particles, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
When the dosage form of described Chinese medicine preparation is capsule, it comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, white butterfly flower and Red Hill medicine are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum and Herba Toreniae Glabrae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: tablet prepared by the present invention
Get Radix limonii sinensis 210g, Radix Buddlejae Butterflybush 180g, Radix seu Ramulus Diospyroris rhombifoliae 360g, Herba Clematidis loureirianae 210g, white butterfly flower 320g, Red Hill medicine 280g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 120g, Semen Momordicae Charantiae 260g, Radix Scrophulariae fargesii 160g, Radix Hedysari 290g, Selenitum 220g, Eucheuma gelatinosum 100g, Herba Toreniae Glabrae 160g, Cortex Machili Thunbergii Radicis 280g, Radix grewiae bilobae 220g, Radix vignae sinensis 100g, Ficus fulva Reinw. 160g, Semen Setariae italicae 240g, Herba Gynurae procumbentis 260g and Caulis Chonemorphae Megacalycis 350g.
Its preparation method comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis are mixed, add relative to mixture 5 times amount determining alcohol be 65% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times of water gagings, boils 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;
3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described mastic compound particles, Pulvis Talci, magnesium stearate is 100: 2.2: 0.26.
Embodiment 2: capsule prepared by the present invention
Get Radix limonii sinensis 250g, Radix Buddlejae Butterflybush 160g, Radix seu Ramulus Diospyroris rhombifoliae 380g, Herba Clematidis loureirianae 250g, white butterfly flower 350g, Red Hill medicine 260g, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 150g, Semen Momordicae Charantiae 280g, Radix Scrophulariae fargesii 190g, Radix Hedysari 260g, Selenitum 250g, Eucheuma gelatinosum 70g, Herba Toreniae Glabrae 190g, Cortex Machili Thunbergii Radicis 260g, Radix grewiae bilobae 250g, Radix vignae sinensis 60g, Ficus fulva Reinw. 190g, Semen Setariae italicae 210g, Herba Gynurae procumbentis 290g and Caulis Chonemorphae Megacalycis 320g.
Its preparation method comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, white butterfly flower and Red Hill medicine are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;
Second step, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum and Herba Toreniae Glabrae are mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 4 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, then load in gelatine capsule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 22-32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.75g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.75 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>43.75 crude drug/kg of the present invention, every day, maximum dosage-feeding was 87.5 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.42g crude drug/day/people, adult body weight in 60KG, average dosage is 0.140g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 27g) oral administration gavage Chinese medicine of the present invention is 625 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 13.27,25.45 and 42.38g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: the tuberculosis of bone and joint patient that all 186 routine cases all derive from this Out-patient Department and are in hospital, all cases all checks through x-ray etc. and makes a definite diagnosis.Be divided into two groups at random, treatment group and each 93 routine patients of matched group.In the routine patient for the treatment of group 93, man 51 example, female 42 example; 17 ~ 73 years old age; The course of disease 1 month ~ 5 years.Wherein, tuberculosis of spine 36 example, tuberculosis of spine 23 example, coxodynia 16 example, tuberculosis of knee joint 13 example, other position tuberculosis 5 example.The routine patient of matched group 93, man 49 example, female 44 example; 16 ~ 68 years old age; The course of disease 1 month ~ 5 years.Wherein, tuberculosis of spine 35 example, tuberculosis of spine 24 example, coxodynia 17 example, tuberculosis of knee joint 12 example, other position tuberculosis 5 example.Treatment group and matched group be no significant difference (P≤0.01) in sex, age, the course of disease and clinical symptoms, has comparability.
Diagnostic criteria: 1, patient and family members can have tuberculosis contact history or pulmonary tuberculosis, tuberculosis of intestine, lymphoid tuberculosis etc. in conjunction with medical history.2, onset is slow, and slightly ache from the beginning of only susceptible change joint skeleton, color of the leather is constant, movable unfavorable, dynamic then the pain increased; With disease progression, local swelling, pain increase the weight of, ankylosis, limitation of activity, amyotrophy.Cold abscess can be had to occur, after abscess is burst, dilute and thin pus, accompanies and loses floccule, not easily closes up.3, early stage General Symptoms is often not obvious, and low grade fever appears in the intermediary and later stages, and generally within 38 DEG C, flushed cheeks, night sweat, becomes thin, metal fatigue, the weakness symptom such as thready and rapid pulse.4, lab testing: active stage erythrocyte sedimentation rate (ESR) obviously speeds, OT (tuberculin test) can be positive, and pus tubercule bacillus cultivates possibility (+), and PCR (polymerase chain reaction) may be positive.5, x-ray takes the photograph sheet: show osteoporosis, decalcification in early days, even partial destruction, and visible sequestrum dissociates a little later, visible bone cavity after sequestrum absorbs, and late period, closing gap was narrow or disappear, in deformity.CT: visible bone destruction, has the high density sequestrum shadow differed in size, and the other abscess of focus can be found.MRI: tuberculosis bone destruction scope, degree and abscess size can be specified, spinal tuberculosis compression of spinal cord degree.
Therapeutic Method:
Matched group: adopt Western medicine to carry out according to 2 stages.First stage, intensive treatment 3 months: intramuscular injection streptomycin 0.75g, every day 1 time; Morning is oral isoniazid 0.3g on an empty stomach, every day 1 time; Morning is oral rifampicin 0.45g on an empty stomach, every day 1 time; Morning is oral ethambutol 0.75g on an empty stomach, every day 1 time.Second stage, after treatment 6 months: morning is oral isoniazid 0.3g on an empty stomach, every day 1 time; Morning is oral rifampicin 0.45g on an empty stomach, every day 1 time; Morning is oral ethambutol 0.75g on an empty stomach, every day 1 time.Be associated with cold abscess person and can extract pus with syringe out from inserting needle around abscess, avoid causing fistula road to be formed.Larger abscess, sequestrum, sinus tract carry out clearance of focal lesion.
Treatment group: on treatment of control group basis, simultaneously oral Chinese medicine embodiment 1 tablet of the present invention, each 3, every day 3 times; Within 3 months, be a course for the treatment of, after three courses for the treatment of, add up therapeutic outcome.
Curative effect judging standard: (1) clinical cure: clinical symptoms and sign disappear, and cold abscess absorbs, or sinus tract healing, systemic conditions is good, and body temperature is normal, and appetite is good; X-ray is taken the photograph sheet display abscess and is disappeared or calcification, and focus edge contour is clear, and bone destruction amendment is good.(2) take a turn for the better: clinical symptoms disappears substantially, and abscess reduces or absorbs, sinus tract secretions reduces or healing; X-ray film display bone repair or bone destruction are stablized.(3) invalid: symptom is not improved, even worsen.X-ray is taken the photograph sheet display focus and is continued development.
Therapeutic outcome: two groups treat 9 months respectively after, statistical result is see table 1 and table 2.
Table 1 liang group treats Clinical efficacy comparison after 9 months (unit: example) respectively
As can be seen from Table 1, treatment group adopts Chinese medicine of the present invention, coordinates western medical treatment tuberculosis of bone and joint, relative to matched group, on therapeutic effect, has significant improvement.
Number and cure rate segmentation statistics (unit: example/%) are cured in a table 2 liang group treatment after 9 months
Group Number of cases Medication 5 months Medication 7 months Medication 9 months
Treatment group 67 29(31.18％) 48(51.61％) 61(65.59％)
Matched group 34 15(16.13％) 23(24.73％) 38(40.86％)
As can be seen from Table 2, treatment group adopts Chinese medicine of the present invention, and coordinate western medical treatment tuberculosis of bone and joint, relative to matched group, not only better efficacy, takes effect also faster.
Untoward reaction: treatment group over the course for the treatment of, there is not the serious adverse reactions such as hepatic and renal function injure, anaphylactic shock or toxicity, have 4 routine patients to occur slight stomach discomfort, feel sick and appetite not good enough, there are insomnias grade poor sleep situations in 3 examples, disappears after equal symptomatic treatment.And matched group over the course for the treatment of, there is liver function injury in 5 examples, and renal function injury appears in 3 examples, and tinnitus, auditory dysesthesia appear in 6 examples, 11 routine first stomach discomfort, loss of appetite, and 7 examples occur that insomnia waits poor sleep situation, disappear after equal symptomatic treatment.
Concrete case: Wang, man, 32 years old, suffers from lumbar spinal tuberculosis and has a surplus for 2 years, see a doctor to the court.Adopt matched group traditional therapy, the tablet of oral inventive embodiments 1, every day 3 times, treats 6 months by each 3 simultaneously, and clinical symptoms and sign disappear, and cold abscess absorbs, or sinus tract healing, and systemic conditions is good, and body temperature is normal, and appetite is good; X-ray is taken the photograph sheet display abscess and is disappeared or calcification, and focus edge contour is clear, and bone destruction amendment is good, clinical cure.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat the Chinese medicine preparation of tuberculosis of bone and joint for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Bai Diehua, Red Hill medicine, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum, Eucheuma gelatinosum, Herba Toreniae Glabrae, Cortex Machili Thunbergii Radicis, Radix grewiae bilobae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix limonii sinensis 15 ~ 25 parts, Radix Buddlejae Butterflybush 10 ~ 20 parts, Radix seu Ramulus Diospyroris rhombifoliae 30 ~ 40 parts, Herba Clematidis loureirianae 15 ~ 30 parts, white butterfly spends 30 ~ 40 parts, Red Hill medicine 15 ~ 30 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 5 ~ 15 parts, Semen Momordicae Charantiae 20 ~ 35 parts, Radix Scrophulariae fargesii 15 ~ 25 parts, Radix Hedysari 25 ~ 35 parts, Selenitum 10 ~ 25 parts, Eucheuma gelatinosum 5 ~ 15 parts, Herba Toreniae Glabrae 15 ~ 25 parts, Cortex Machili Thunbergii Radicis 20 ~ 35 parts, Radix grewiae bilobae 20 ~ 30 parts, Radix vignae sinensis 5 ~ 15 parts, Ficus fulva Reinw. 10 ~ 25 parts, Semen Setariae italicae 15 ~ 25 parts, Herba Gynurae procumbentis 20 ~ 30 parts and Caulis Chonemorphae Megacalycis 25 ~ 35 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix limonii sinensis 20 ~ 25 parts, Radix Buddlejae Butterflybush 15 ~ 20 parts, Radix seu Ramulus Diospyroris rhombifoliae 35 ~ 40 parts, Herba Clematidis loureirianae 20 ~ 25 parts, white butterfly spends 30 ~ 35 parts, Red Hill medicine 25 ~ 30 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 10 ~ 15 parts, Semen Momordicae Charantiae 25 ~ 30 parts, Radix Scrophulariae fargesii 15 ~ 20 parts, Radix Hedysari 25 ~ 30 parts, Selenitum 20 ~ 25 parts, Eucheuma gelatinosum 5 ~ 10 parts, Herba Toreniae Glabrae 15 ~ 20 parts, Cortex Machili Thunbergii Radicis 25 ~ 30 parts, Radix grewiae bilobae 20 ~ 25 parts, Radix vignae sinensis 5 ~ 10 parts, Ficus fulva Reinw. 15 ~ 20 parts, Semen Setariae italicae 20 ~ 25 parts, Herba Gynurae procumbentis 25 ~ 30 parts and Caulis Chonemorphae Megacalycis 30 ~ 35 parts.
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Radix limonii sinensis 21 parts, Radix Buddlejae Butterflybush 18 parts, Radix seu Ramulus Diospyroris rhombifoliae 36 parts, Herba Clematidis loureirianae 21 parts, white butterfly spend 32 parts, Red Hill medicine 28 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 12 parts, Semen Momordicae Charantiae 26 parts, Radix Scrophulariae fargesii 16 parts, Radix Hedysari 29 parts, Selenitum 22 parts, Eucheuma gelatinosum 10 parts, Herba Toreniae Glabrae 16 parts, Cortex Machili Thunbergii Radicis 28 parts, Radix grewiae bilobae 22 parts, Radix vignae sinensis 10 parts, Ficus fulva Reinw. 16 parts, Semen Setariae italicae 24 parts, Herba Gynurae procumbentis 26 parts and Caulis Chonemorphae Megacalycis 35 parts.
5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described mastic compound particles, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, white butterfly flower and Red Hill medicine are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum and Herba Toreniae Glabrae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and it comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, Radix vignae sinensis, Ficus fulva Reinw., Semen Setariae italicae, Herba Gynurae procumbentis and Caulis Chonemorphae Megacalycis are mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;
5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described mastic compound particles, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.
8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Radix limonii sinensis, Radix Buddlejae Butterflybush, Radix seu Ramulus Diospyroris rhombifoliae, Herba Clematidis loureirianae, white butterfly flower and Red Hill medicine are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching, Semen Momordicae Charantiae, Radix Scrophulariae fargesii, Radix Hedysari, Selenitum and Herba Toreniae Glabrae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
CN201610003994.1A 2016-01-01 2016-01-01 Traditional Chinese medicine preparation for treating tuberculosis of bone and joint and preparation method for traditional Chinese medicine preparation Pending CN105434963A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105748846A (en) * 2016-05-04 2016-07-13 朱宝敏 Traditional Chinese medicine preparation for treating anemic heart disease and preparation method of traditional Chinese medicine preparation
CN105853806A (en) * 2016-05-27 2016-08-17 王德欣 Traditional Chinese medicine for treating cholestatic hepatitis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
曹殿鸣等: "骨疽胶囊治疗骨与关节结核", 《中原医刊》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105748846A (en) * 2016-05-04 2016-07-13 朱宝敏 Traditional Chinese medicine preparation for treating anemic heart disease and preparation method of traditional Chinese medicine preparation
CN105853806A (en) * 2016-05-27 2016-08-17 王德欣 Traditional Chinese medicine for treating cholestatic hepatitis and preparation method thereof

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Application publication date: 20160330