CN105853806A - Traditional Chinese medicine for treating cholestatic hepatitis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating cholestatic hepatitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating cholestatic hepatitis and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicine materials: coniogramme intermedia hieron., elaeagnus conferta, effuse baliospermum root and leaf, bitter bamboo shoot, Indian glorybower herb, buxus microphylla sieb, all-grass of Chinese aeluropus, multiflora rose root, acanthopanax setchuenensis, cushaw root, manyflower supplejack stem and leaf, conespike flemingia root, Japanese xylosma root, solanum cathayanum, common adenostema herb, calamus margaritae, hance brandisia herb, mallow, polygonum senticosum, whitefruit stonecrop herb and aeschynanthus acuminatus. The traditional Chinese medicine can be combined with conventional western medicines to treat cholestatic hepatitis, and is convenient to use, better in curative effect, free of toxic or side effect and adverse reaction and simple in preparation process.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Cholestatic hepatitis for the treatment of
Chinese medicine and preparation method thereof.
Background technology
Cholestatic hepatitis is bile dyspoiesis in liver cell, bile duct secretions or the impaired institute of bile flow
The disease caused.The reason of Cholestatic hepatitis is the most complex, including infectivity, Drug, from
Body immunity, gestational, heredity, organ transplant rejection, severe infections and toxaemia, length
Phase application total parenteral nutrition section causes hepatic lesion, postoperative cholestasis, Alcoholic cholestasis etc..
Mainly show as intrahepatic cholestasis jaundice, be sometimes difficult to difference with extrahepatic cholestasis.Patient often shows severe
Jaundice, and the duration is long, whole skin itch, and urine color depth is yellow like strong tea sample, defecates greyish white such as pottery
Ashen.The common symptom of digestive tract of hepatitis patient is such as lost the appetite, is detested the diseases such as oil, n and V, abdominal distension
Shape performance is similar or relatively light, and overall health of patients is also good than acute icteric hepatitis.
But the whole course of disease is long, jaundice at least continues more than 3 weeks, and the even several months does not moves back or disappears slowly.
Laboratory examination bilirubin is significantly raised, based on bilirubin direct, and alkaline phosphatase (ALP), paddy radon acyl
Transpeptidase (GGT), cholesterol all raise, and ALT moderate raises.Dung fluid inspection urine bilirubin is positive and urinates courage
Former feminine gender, this is the feature of obstructive jaundice because as icteric hepatitis should be urine bilirubin and urine courage
The former equal positive.Ultrasound diagnosis has liver to increase, and extrahepatic duct is not expanded, and this point can be with extrahepatic cholestasis
Jaundice distinguishes.Though cholestatic hepatitis jaundice is more serious, but the state of an illness is light, and appetite is good, general hepatitis symptom
The most relatively the lighter.
Cholestatic hepatitis belongs to the category of " jaundice " " yang jaundice " in traditional Chinese medicine, and its interpretation of the cause, onset and process of an illness is wet
Heat, hemostasis are tied mutually, liver dysfunction, stifling bile, and the bile flowing outside the biliary passages overflows in skin, mesh eyeball." all
Pathogeny wait opinion " in say " including blood stasis, the most constantly body heat and turn to be yellow." facing card guide " says " qi and blood
Not all right then jaundice ".Li Ting say " though cold jaundice differs, all because of misuse temperature medicine or attacked with fire too far, or
Under losing sweat and rushing down, so that blood-head is shown in that euchroic is in skin in Yangming Channel "." Plain Questions impotence opinion " medium cloud, " liver
Gas heat then courage rushes down ", " courage rushes down then jaundice "." implied meaning grass " is said " gallbladder-heat,biliary fever, juice is full and overflows in outward,
Gradually to ooze in channels and collaterals, then yellow skin and eye "." facing card guide " also indicates that " work of yang jaundice, wet from fire
Changing, interior stagnation of heat, gallbladder-heat liquid rushes down ".Lu Yuanlei says, " origin cause of formation of jaundice must be mixed into blood because of bile
Circulation is caused ..., if due to illness pathogens, stasis of blood word implies again the meaning of stasis, cholestegnosis, enters blood
Liquid circulates, there is jaundice, and the accumulated heat being dispersed of meaning ".
Summary of the invention
The technical problem to be solved is, utilizes the theory of traditional Chinese medical science that China is traditional, it is provided that a kind of
Determined curative effect and the Chinese medicine and preparation method thereof of the little treatment Cholestatic hepatitis of toxic action.
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating Cholestatic hepatitis,
Described Chinese medicine includes following raw medicinal material: black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb,
Chinese box root, Herba Aeluropi sinensis, japanese rose root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, conespike flemingia root, japanese xylosma root,
Bittersweet, adenostemma laveniaKuntze, herba fibraureae recisae, cat flower, high mallow, corridor mattress, rock pine and stone banyan.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: black brave 7 20～30
Part, elaeagnus conferta fruits 15～25 parts, common vetch seed 10～20 parts, bitter bamboo shoot 15～30 parts, indian glorybower herb 30～
40 parts, Chinese box root 10～25 parts, Herba Aeluropi sinensis 5～15 parts, japanese rose root 10～20 parts, another name for Sichuan Province slender acanthopanax 15～
25 parts, cushaw root 15～30 parts, swamp eel rattan 20～35 parts, conespike flemingia root 5～15 parts, japanese xylosma root 15～
25 parts, bittersweet 20～30 parts, adenostemma laveniaKuntze 10～25 parts, herba fibraureae recisae 30～40 parts, cat spend 15～
30 parts, high mallow 10～25 parts, corridor mattress 5～15 parts, rock pine 15～25 parts and stone banyan 10～20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: black brave seven
25～30 parts, elaeagnus conferta fruits 15～20 parts, common vetch seed 10～15 parts, bitter bamboo shoot 20～25 parts, long tube vacation
Jasmine 35～40 parts, Chinese box root 15～20 parts, Herba Aeluropi sinensis 10～15 parts, japanese rose root 15～20 parts,
Another name for Sichuan Province slender acanthopanax 20～25 parts, cushaw root 25～30 parts, swamp eel rattan 30～35 parts, conespike flemingia root 5～10
Part, japanese xylosma root 15～20 parts, bittersweet 25～30 parts, adenostemma laveniaKuntze 15～20 parts, herba fibraureae recisae 30～
35 parts, cat spend 20～25 parts, high mallow 15～20 parts, corridor mattress 5～10 parts, rock pine 20～25 parts and
Stone banyan 15～20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: black brave seven
26 parts, elaeagnus conferta fruits 19 parts, common vetch seed 12 parts, bitter bamboo shoot 25 parts, indian glorybower herb 36 parts, Chinese box root
18 parts, Herba Aeluropi sinensis 12 parts, japanese rose root 19 parts, another name for Sichuan Province slender acanthopanax 21 parts, cushaw root 29 parts, swamp eel rattan 32
Part, conespike flemingia root 10 parts, japanese xylosma root 16 parts, bittersweet 28 parts, adenostemma laveniaKuntze 16 parts, herba fibraureae recisae
35 parts, cat spend 21 parts, high mallow 19 parts, 7 parts of corridor mattress, rock pine 25 parts and stone banyan 19 parts.
When the formulation of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb, Chinese box root, horse
Stumble grass, japanese rose root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan and conespike flemingia root mixes in proportion, add relative to
3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% extract 2 times～4 times, and each 2
Hour～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into 70 DEG C of relative densities be 1.30～
The lotion of 1.32, standby；
Second step, mixes in proportion by surplus stock medicinal material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the lotion mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum are dried,
Get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains lotion mixture；Described
Lotion and the weight ratio of starch be 1: 0.01～0.02；Described lotion mixture is carried out pelletization treatment,
It is dried and processes, the lotion compound particles obtained；
5th step, is carried out at mixing successively by described lotion compound particles and talcum powder, magnesium stearate
Reason, compressing tablet process, Cotton seeds, obtain Chinese medicinal tablet finished product；Described particle, talcum powder, tristearin
The weight ratio of acid magnesium is 100: 1～3: 0.15～0.3.
When the formulation of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb and Chinese box root by institute
State ratio mixing, add and extract volatile oil, by the volatile oil β of acquisition relative to the water of mixture 4～6 times
-cyclodextrin encapsulated, volatile oil is 1: 3～6 with the ratio of beta-schardinger dextrin, stirs 75 minutes～90 minutes,
Temperature 30 DEG C～50 DEG C, obtains volatile oil clathrate compound, standby；Separately aqueous extract is concentrated into when 60 DEG C relative
Density is the clear cream of 1.15～1.17；
Second step, by another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, japanese xylosma root, bittersweet, adenostemma laveniaKuntze and
Cat flower is mixed in described ratio, adds relative to the ethanol that mixture 6～8 times amount determining alcohol is 80%～90%
Refluxing extraction 3～5 times, each 2～3 hours, filter, and filtrate merges, and reclaims ethanol, is concentrated into 60 DEG C
Time relative density be 1.20～1.22 clear cream, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10
Times amount water, boils 6～8 hours, filter, when being concentrated into 60 DEG C relative density be 1.28～1.30 clear
Cream；
4th step, mixes the clear cream of the first step, second step, the 3rd step, 60 DEG C～70 DEG C of reduced vacuum
Being dried, get dry extract powder；
5th step, is sufficiently mixed dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, with
Rear addition is relative to volatile oil clathrate compound described in 100 weight portions and the mixture of dried cream powder, 5～8 weight portions
Sodium carboxymethyl starch, 10～50 weight starch mix, add 150～200 weight portion determining alcohols
It is 80%～90% alcohol granulation, is dried, whole grain, is subsequently added relative to volatile oil described in 100 weight portions
Inclusion compound and the mixture of dried cream powder, 3～5 weight portion magnesium stearates, it is then charged in gelatine capsule.
Beneficial effects of the present invention: Chinese medicine of the present invention can combine conventional western medicine treatment cholestatic liver
Inflammation, easy to use, result for the treatment of is more preferable, has no side effect and bad reaction, and preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine treating Cholestatic hepatitis, Chinese medicine includes following bulk drug
Material: black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb, Chinese box root, Herba Aeluropi sinensis, rose
Root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, conespike flemingia root, japanese xylosma root, bittersweet, adenostemma laveniaKuntze,
Herba fibraureae recisae, cat flower, high mallow, corridor mattress, rock pine and stone banyan.
The pharmacology of various raw medicinal materials is as follows:
Black brave seven: [another name] rhizoma panasis japonici, horsepower across, siphon, iron seven, black imperial seven, great Ye dog tooth
Seven.[source] medicinal material Ji Yuan: for the rhizome of Hemionitidaceae plant Coniogramme intermedia Hieron.Gather and store:
Excavate rhizome autumn, remove fibrous root and earth, dry.[nature and flavor] are sweet；Light；Flat.[return through] wing
Guang；Large intestine channel.[function cures mainly] eliminating dampness and heat；Expelling wind and activating blood flow.Main urine leaching is puckery；Dysentery；Have loose bowels；
Under band；Arthralgia due to wind-dampness；Sore；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Elaeagnus conferta fruits: [another name] ox louse fruit, sheep mountain miaow tree, sarment thorny elaeagnus.[source] medicinal material
Ji Yuan: climb up by holding on to the complete stool of thorny elaeagnus for Elaeangnaceae plant.[nature and flavor] acid；Flat.[function cures mainly]
Relieving cough and asthma；Antidiarrheal；Hemostasis；Activating blood circulation and reducing swelling.Main chronic cough；Asthma；Diarrhoea；Spit blood；Spitting of blood；Yellow
Subcutaneous ulcer；Arthralgia due to wind-dampness；Fall dozen stasis of blood to swell；Abscess of throat.[extracts] " China's book on Chinese herbal medicine "
Common vetch seed: [another name] is embraced winter electricity, dissipated micro-seed.[source] medicinal material Ji Yuan: dissipate for euphorbia plant
The root of micro-seed, skin or leaf.[nature and flavor] are pungent；Tepor.[return through] liver；Courage；Large intestine channel.[function
Cure mainly] removing toxic substances expelling parasite；Activating blood circulation and reducing swelling.Main jaundice；Ascariasis；Wound swells and ache；Fracture.[extracts]
" China's book on Chinese herbal medicine "
Bitter bamboo shoot: [another name] bitter bamboo shoot.[source] medicinal material Ji Yuan: for the tender seedling of grass bitter bamboo.
[nature and flavor] are bitter；Cold.[function cures mainly] clearing heat and relieving fidgetness；Dehumidifying；Li Shui.Main pyreticosis polydipsia；Damp and hot
Jaundice；Difficult urination；Tinea pedis.[each discussion] supplement to the Herbal: master sits up, and removes appearance tongue
Upper heat is yellow, quenches one's thirst, improving eyesight, relieving alcoholism, heat extraction gas, strong people.[extracts] " China's book on Chinese herbal medicine "
Indian glorybower herb: [another name] valida limaciopsis.[source] comes from " choosing of Simao, Yunnan Chinese herbal medicine ".
[source] medicinal material Ji Yuan: for the complete stool of dicotyledon medicine Verbenaceae long tube smalt.Gather and
Storage: the whole year can adopt, segment, dries or using fresh herb.[nature and flavor] are bitter；Cool.[return through] liver；Kidney；
Bladder warp.[function cures mainly] activating blood circulation and reducing swelling；Clearing heat and promoting diuresis.Main damp-heat gonorrhoea；Difficult urination；Malaria；
Beriberoid pyretic arthralgia；Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Chinese box root: [source] medicinal material Ji Yuan: for Buxaceae plant Chinese littleleaf box or the root of Buxus bodinieri.[property
Taste] bitter；Pungent；Flat.[return through] Liver Channel.[function cures mainly] dispelling wind stopping cough；Removing damp-heat.Main air
Pain of dampness syndrome；Cough due to common cold；Jaundice with damp-heat pathogen.[extracts] " China's book on Chinese herbal medicine "
Herba Aeluropi sinensis: [another name] roe hair, leaflet reed, dwarf sheareria herb, gingival cyst of mucous gland in the newborn head.[source] medicinal material Ji Yuan:
Herb for grass Herba Aeluropi sinensis.[nature and flavor] are sweet；Light；Cool.[function cures mainly] reducing fever and causing diuresis,
Removing jaundice.Main icteric hepatitis；Cirrhosis；Ascites；Cholecystitis.[each discussion] " Xinhua's book on Chinese herbal medicine guiding principle
Want ": herb: taste is sweet, light, property is put down.There is the function of reducing fever and causing diuresis.For icteric hepatitis, the courage wing
The diseases such as inflammation and cirrhotic ascites.[extracts] " China's book on Chinese herbal medicine "
Japanese rose root: [source] comes from Compendium of Material Medica.[source] medicinal material Ji Yuan: plant for the rose family
The root of thing multiflora rose.Gathering and store: autumn uproots, cleaning, section is dried standby.[nature and flavor] are bitter
Puckery；Cool；Nontoxic.[return through] spleen；Stomach；Kidney channel.[function cures mainly] is clearing heat and detoxicating, dispels rheumatism,
Promoting blood circulation for regulating menstruation, controlling nocturnal emission with astringent drugs contracting urine, disappear bone sticking.Main sore, carbuncle and painful swelling, scalds, aphtha, hemorrhoid blood, nosebleed epistaxis, closes
Joint pain, irregular menstruation, dysmenorrhoea, protracted dysentery does not heals, the enuresis, frequent micturition, leukorrhea, the prolapse of uterus,
Bone sticking.[extracts] " China's book on Chinese herbal medicine "
Another name for Sichuan Province slender acanthopanax: [source] medicinal material Ji Yuan: for the root skin of Araliaceae another name for Sichuan Province slender acanthopanax.Gather and store:
Autumn uproots, and cleans, and removes fibrous root, takes advantage of and fresh strips root skin, segment, dries.[nature and flavor] taste is pungent；
Micro-hardship；Warm in nature.[function cures mainly] expelling wind and removing dampness；Relax the muscles and stimulate the blood circulation；Relieving cough and asthma.Main air pain of dampness syndrome；
Muscles and bones impotence is soft；Contraction is numb；Paralysis；Polio；Oedema；Skin pruritus；Cough；Asthma.[pluck
Record] " China's book on Chinese herbal medicine "
Cushaw root: [source] medicinal material Ji Yuan: for the root of cucurbitaceous plant pumpkin.[nature and flavor] taste is sweet；
Light；Property flat.[return through] returns liver；Bladder warp.[function cures mainly] dampness removing heat；Promoting lactation.Main damp and hot
Stranguria；Jaundice；Dysentery；Alactation.[each discussion] " conventional glossary of Herbs and Drugs among the people ": detumescence,
Dehumidifying heat, removing toxic substances, expectoration, lactogenesis.Control jaundice and dysentery.[extracts] " China's book on Chinese herbal medicine "
Swamp eel rattan: [another name] purple sieve flower, mabi, elephant skin grass, hook youngster's bar.[source] medicinal material Ji Yuan:
The hook stem of catechu, leaf or root is spent more for Rhamnaceae plant.[nature and flavor] are sweet；Puckery；Tepor.[return through]
Liver；Gallbladder channel.[function cures mainly] dispels rheumatism；Promoting blood circulation and stopping pain.Main air pain of dampness syndrome；Stomachache；Dysmenorrhoea；
Postpartum abdominal pain；Traumatic injury；Tuberculous osteoarthropathy；Osteomyelitis；Infantile malnutrition；Hepatitis；Cirrhosis.[each
Family is discussed] 1. " Fujian traditional herbal medicine ": rattan: diuresis is detoxified.Control jaundice with damp-heat pathogen.2. " Luchuan is originally
Grass ": refreshing and detoxicating, cool blood, hemostasis.Controlling blood-head bleeding from five sense organs or subcutaneous tissue, wound is red and swollen.[extracts] " China is originally
Grass "
Conespike flemingia root: [another name] coughs TIESAOBA careless, big.[source] medicinal material Ji Yuan: plant for pulse family
The very heavy root pulled out of thing fruticuli.[nature and flavor] micro-hardship；Sweet；Cool.[return through] lung；The spleen channel.[function
Cure mainly] clearing heat and eliminating phlegm；Eliminating dampness and dredging channels；Invigorating the spleen disappears infantile malnutrition due to digestive disturbances or intestinalparasites.Main cold, fever；Lung heat cough；Asthma；
Pertussis；Arthralgia due to wind-dampness；Jaundice；Dysmenorrhoea；Infantile malnutrition；Diarrhoea；Indigestion.[extracts] " in
China's book on Chinese herbal medicine "
Japanese xylosma root: [source] medicinal material Ji Yuan: for the root of Flacourtiaceae plant toothed oak wood.[nature and flavor] bitter；
Property flat.[return through] liver；The spleen channel.[function cures mainly] detoxifies；Dampness removing；Dissipate the stasis of blood；Hasten parturition.Main jaundice；
Dysentery；Oedema；Lung core is spat blood；Scrofula；Treating swelling and pain by traumatic injury；Difficult labour；The retention of dead fetus.[each discussion] 1.
" vegetation just side ": subcutaneous ulcer of harnessing the Yellow River, mouse fistula, difficult labour, fails before being carrying out.2. " conventional glossary of Herbs and Drugs among the people ":
Dehumidifying, row liver network.Control vim and vigour stomachache.[extracts] " China's book on Chinese herbal medicine "
Bittersweet: [another name] bittersweet, air draft rattan, hair sow rattan.[source] medicinal material Ji Yuan:
Herb for the plant of Solanaceae hair year the most rotten heart.[nature and flavor] taste is sweet；Bitter；Cold in nature.[function cures mainly] is clear
Thermal detoxification；Dispelling wind and relieving convulsion.Main fever in children infantile convulsion；Jaundice；Cough with lung heat；Acute toothache；Scrofula；
Woman uterine bleeding, band under, pelvic infecton.[extracts] " China's book on Chinese herbal medicine "
Adenostemma laveniaKuntze: [another name] Radix Alangii [Simao, Yunnan], water pepper, common adenostema herb, sweat Soviet Union fiber crops.[come
Source] it is that composite family adenostemma laveniaKuntze belongs to adenostemma laveniaKuntze, with all herbal medicine.Summer, autumn gather, and clean and dry.[nature and flavor]
Hardship, cold.[function cures mainly] clearing heat and promoting diuresis, removing toxicity for detumescence.For high heat of catching a cold, bronchitis, pharynx
Laryngitis, tonsillitis, icteric hepatitis；Carbuncle furuncle sore, snake bite are controlled in external application.[extracts] " whole nation
Chinese herbal medicine collects "
Herba fibraureae recisae: [another name] wintergreen barberry root, coptis rattan, herba aristolochiae, gold key.[source] medicinal material Ji Yuan:
Rhizome or leaf for menispermaceous plants herba fibraureae recisae.[nature and flavor] are bitter；Cold in nature.[return through] heart；Liver Channel.[merit
Can cure mainly] clearing heat and detoxicating；Dampness removing.Main acute tonsillitis, sphagitis, the infection of the upper respiratory tract；Conjunctiva
Scorching；Jaundice；Gastroenteritis；Dysentery；Children's indigestion；Food poisoning；Salpingitis；Acute and chronic
Endometrium is scorching；Acute pelvitis of pelvic cavity；Vaginitis；Sore furuncle；Burn and scald.[extracts] " China's book on Chinese herbal medicine "
Cat flower: [another name] honeybee sugar bowl (" Guizhou folk medicine "), hance brandisia herb, carrys out river rattan (" four
River Chinese medicinal herbal "), cat narrows flower (" Guizhou herbal medicine "), Hance Brandisia Herb, honey fruit, iron woods bar, little Bai
Leaf (" Yunnan Chinese herbal medicine "), Helwingia himalaica (" Kunming conventional herbal medicine among the people "), the wild capsule of weeping forsythia (" cloud
South Chinese herbal medicine choosing ").[source] " Traditional Chinese Medicine in Sichuan will ".[source] is that goatweed leaflet comes
The herb of river rattan.[nature and flavor] 1. " Guizhou folk medicine ": " cool in nature, mildly bitter flavor ".2. " in Sichuan
Medicine will ": " cool in nature, puckery, nontoxic ".[function cures mainly] expelling wind and removing dampness, clearing away heat to stop bleeding.Control rheumatism,
Edema, rushes down dysentery, jaundice, spits blood, palpitaition, osteomyelitis.1. " Guizhou folk medicine ": " control dysentery,
Disappear edema, cough-relieving blood ".2. " Traditional Chinese Medicine in Sichuan will ": " control and tremble with fear, burn-out is not moved back and vomits ".[pluck
Record] " Chinese medicine voluminous dictionary "
High mallow: [another name], ant, little ripe season flower, nightshade, malva leaf, Chinese mallow, wheat straw flower.
[source] medicinal material Ji Yuan: for flower, leaf and the stem of Malvaceae plant high mallow.[nature and flavor] are salty；Cold.[merit
Can cure mainly] diuresis defaecation；Clearing heat and detoxicating.Main stool and urine is the most smooth；Under band；Scrofula；Throat swells
Bitterly.[extracts] " China's book on Chinese herbal medicine "
Corridor mattress: [another name] red big crow acid grass, Shi Zongcao, cat tongue grass, Herba Lespedezae Cuneatae, safflower snake are only.
[source] medicinal material Ji Yuan: for the herb of polygonaceae plant thorn knotweed.[nature and flavor] are bitter；Acid；Micro-pungent；Property flat.[merit
Can cure mainly] clearing heat and detoxicating；Antipruritic with wet；Dissipate stagnation resolvation to swell.Main ulcerative carbuncle malignant boil furuncle；Venomous snake bite；Eczema；Yellow
Water sore；Herpes zoster；Traumatic injury；Pleased, internal piles external piles [each discussion] 1. Jiangxi " herbal medicine handbook ":
Promoting circulation of blood dissipates the stasis of blood, subdhing swelling and detoxicating.Controlling carbuncle of the nape, altauna furuncle, baby's skin infections of newborn infants, snake bite, get injured by a fall, eczema is itched
Bitterly, external piles, internal piles.2. " Gansu Chinese herbal medicine handbook ": clearing heat and detoxicating, regulating qi-flowing for relieving pain, Gu de-.Control children's
The skin infections of newborn infants, stomach Qi pain, the prolapse of uterus.[extracts] " China's book on Chinese herbal medicine "
Rock pine: [another name] chrysanthemum rock pine.[source] medicinal material Ji Yuan: for crassulaceae plants gingko red-spotted stonecrop
Herb.[nature and flavor] are pungent；Cold.[return through] kidney；Liver Channel.[function cures mainly] is clearing heat and detoxicating；Cool
Blood.Main hepatitis；Otitis media suppurative；Burn and scald.[extracts] " China's book on Chinese herbal medicine "
Shi Rong: [another name] great Ye banyan rattan, cliff wind, milk tree, the most leeward, Shi Nanfeng.[source]
Medicinal material Ji Yuan: for the herb of Gesneriaceae awns hair lettuce tongue.[nature and flavor] taste is sweet；Property flat.[function
Cure mainly] the peaceful heart；Nourishing the liver；Cough-relieving；Pain relieving.Main neurasthenia, chronic hepatitis；Cough；Treating rheumatic ostealgia；
Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: black brave 7 20～30
Part, elaeagnus conferta fruits 15～25 parts, common vetch seed 10～20 parts, bitter bamboo shoot 15～30 parts, indian glorybower herb 30～
40 parts, Chinese box root 10～25 parts, Herba Aeluropi sinensis 5～15 parts, japanese rose root 10～20 parts, another name for Sichuan Province slender acanthopanax 15～
25 parts, cushaw root 15～30 parts, swamp eel rattan 20～35 parts, conespike flemingia root 5～15 parts, japanese xylosma root 15～
25 parts, bittersweet 20～30 parts, adenostemma laveniaKuntze 10～25 parts, herba fibraureae recisae 30～40 parts, cat spend 15～
30 parts, high mallow 10～25 parts, corridor mattress 5～15 parts, rock pine 15～25 parts and stone banyan 10～20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: black brave seven
25～30 parts, elaeagnus conferta fruits 15～20 parts, common vetch seed 10～15 parts, bitter bamboo shoot 20～25 parts, long tube vacation
Jasmine 35～40 parts, Chinese box root 15～20 parts, Herba Aeluropi sinensis 10～15 parts, japanese rose root 15～20 parts,
Another name for Sichuan Province slender acanthopanax 20～25 parts, cushaw root 25～30 parts, swamp eel rattan 30～35 parts, conespike flemingia root 5～10
Part, japanese xylosma root 15～20 parts, bittersweet 25～30 parts, adenostemma laveniaKuntze 15～20 parts, herba fibraureae recisae 30～
35 parts, cat spend 20～25 parts, high mallow 15～20 parts, corridor mattress 5～10 parts, rock pine 20～25 parts and
Stone banyan 15～20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: black brave seven
26 parts, elaeagnus conferta fruits 19 parts, common vetch seed 12 parts, bitter bamboo shoot 25 parts, indian glorybower herb 36 parts, Chinese box root
18 parts, Herba Aeluropi sinensis 12 parts, japanese rose root 19 parts, another name for Sichuan Province slender acanthopanax 21 parts, cushaw root 29 parts, swamp eel rattan 32
Part, conespike flemingia root 10 parts, japanese xylosma root 16 parts, bittersweet 28 parts, adenostemma laveniaKuntze 16 parts, herba fibraureae recisae
35 parts, cat spend 21 parts, high mallow 19 parts, 7 parts of corridor mattress, rock pine 25 parts and stone banyan 19 parts.
When the formulation of described Chinese medicine is tablet, and it comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb, Chinese box root, horse
Stumble grass, japanese rose root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan and conespike flemingia root mixes in proportion, add relative to
3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% extract 2 times～4 times, and each 2
Hour～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into 70 DEG C of relative densities be 1.30～
The lotion of 1.32, standby；
Second step, mixes in proportion by surplus stock medicinal material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the lotion mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum are dried,
Get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains lotion mixture；Described
Lotion and the weight ratio of starch be 1: 0.01～0.02；Described lotion mixture is carried out pelletization treatment,
It is dried and processes, the lotion compound particles obtained；
5th step, is carried out at mixing successively by described lotion compound particles and talcum powder, magnesium stearate
Reason, compressing tablet process, Cotton seeds, obtain Chinese medicinal tablet finished product；Described particle, talcum powder, tristearin
The weight ratio of acid magnesium is 100: 1～3: 0.15～0.3.
When the formulation of described Chinese medicine is capsule, and it comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb and Chinese box root by institute
State ratio mixing, add and extract volatile oil, by the volatile oil β of acquisition relative to the water of mixture 4～6 times
-cyclodextrin encapsulated, volatile oil is 1: 3～6 with the ratio of beta-schardinger dextrin, stirs 75 minutes～90 minutes,
Temperature 30 DEG C～50 DEG C, obtains volatile oil clathrate compound, standby；Separately aqueous extract is concentrated into when 60 DEG C relative
Density is the clear cream of 1.15～1.17；
Second step, by another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, japanese xylosma root, bittersweet, adenostemma laveniaKuntze and
Cat flower is mixed in described ratio, adds relative to the ethanol that mixture 6～8 times amount determining alcohol is 80%～90%
Refluxing extraction 3～5 times, each 2～3 hours, filter, and filtrate merges, and reclaims ethanol, is concentrated into 60 DEG C
Time relative density be 1.20～1.22 clear cream, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10
Times amount water, boils 6～8 hours, filter, when being concentrated into 60 DEG C relative density be 1.28～1.30 clear
Cream；
4th step, mixes the clear cream of the first step, second step, the 3rd step, 60 DEG C～70 DEG C of reduced vacuum
Being dried, get dry extract powder；
5th step, is sufficiently mixed dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, with
Rear addition is relative to volatile oil clathrate compound described in 100 weight portions and the mixture of dried cream powder, 5～8 weight portions
Sodium carboxymethyl starch, 10～50 weight starch mix, add 150～200 weight portion determining alcohols
It is 80%～90% alcohol granulation, is dried, whole grain, is subsequently added relative to volatile oil described in 100 weight portions
Inclusion compound and the mixture of dried cream powder, 3～5 weight portion magnesium stearates, it is then charged in gelatine capsule.
Hereinafter use embodiment to describe embodiments of the present invention in detail, whereby how the present invention is applied
Technological means solves technical problem, and the process that realizes reaching technique effect can fully understand and real according to this
Execute.
Embodiment 1: tablet prepared by the present invention
Take black brave seven 260g, elaeagnus conferta fruits 190g, common vetch seed 120g, bitter bamboo shoot 250g, indian glorybower herb 360g,
Chinese box root 180g, Herba Aeluropi sinensis 120g, japanese rose root 190g, another name for Sichuan Province slender acanthopanax 210g, cushaw root 290g, swamp eel
Rattan 320g, conespike flemingia root 100g, japanese xylosma root 160g, bittersweet 280g, adenostemma laveniaKuntze 160g, Huang
Rattan 350g, cat flower 210g, high mallow 190g, corridor mattress 70g, rock pine 250g and Shi Rong 190g.
Its preparation method comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb, Chinese box root, horse
Stumble grass, japanese rose root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan and conespike flemingia root mixes in proportion, add relative to
Mixture 5 times amount determining alcohol be 60% alcohol reflux extract 2 times, each 3 hours, filter, filtrate
Merging, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the lotion of 1.31, standby；
Second step, mixes in proportion by surplus stock medicinal material, adds relative to mixture 4 times amount water, boils
4 hours, filtering, being concentrated into 70 DEG C of relative densities is the lotion of 1.29；
3rd step, the lotion mixing first step, second step obtained, 65 DEG C of reduced vacuum are dried, and obtain dry
Cream powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains lotion mixture；Described
Lotion and the weight ratio of starch be 1: 0.02；Described lotion mixture is carried out pelletization treatment, is dried
Process, the lotion compound particles obtained；
5th step, is carried out at mixing successively by described lotion compound particles and talcum powder, magnesium stearate
Reason, compressing tablet process, Cotton seeds, obtain Chinese medicinal tablet finished product；Described particle, talcum powder, tristearin
The weight ratio of acid magnesium is 100: 2.8: 0.22.
Embodiment 2: capsule prepared by the present invention
Take black brave seven 290g, elaeagnus conferta fruits 160g, common vetch seed 150g, bitter bamboo shoot 230g, indian glorybower herb 380g,
Chinese box root 160g, Herba Aeluropi sinensis 150g, japanese rose root 170g, another name for Sichuan Province slender acanthopanax 240g, cushaw root 260g, swamp eel
Rattan 350g, conespike flemingia root 70g, japanese xylosma root 190g, bittersweet 260g, adenostemma laveniaKuntze 180g, Huang
Rattan 320g, cat flower 250g, high mallow 160g, corridor mattress 100g, rock pine 230g and Shi Rong 160g.
Its preparation method comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb and Chinese box root by institute
State ratio mixing, add relative to 6 times of mixture water extract volatile oil, by obtain volatile oil β-
Cyclodextrin encapsulated, volatile oil is 1: 4.7 with the ratio of beta-schardinger dextrin, stirs 80 minutes, temperature 45 C,
Obtain volatile oil clathrate compound, standby；Another time aqueous extract is concentrated into 60 DEG C relative density be 1.17 clear
Cream；
Second step, by another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, japanese xylosma root, bittersweet, adenostemma laveniaKuntze and
Cat flower is mixed in described ratio, adds and extracts 3 relative to the alcohol reflux that mixture 6 times amount determining alcohol is 90%
Secondary, each 2 hours, to filter, filtrate merges, and reclaims ethanol, and when being concentrated into 60 DEG C, relative density is 1.22
Clear cream, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 times amount
Water, boils 8 hours, filters, and when being concentrated into 60 DEG C, relative density is the clear cream of 1.29；
4th step, mixes the clear cream of the first step, second step, the 3rd step, and 70 DEG C of reduced vacuum are dried,
Get dry extract powder；
5th step, is sufficiently mixed dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, with
Rear addition is relative to volatile oil clathrate compound described in 100 weight portions and the mixture of dried cream powder, 8 weight portion carboxylics
Methyl starch sodium, 24 weight starch mix, and adding 165 weight portion determining alcohols is 85% ethanol system
Grain, is dried, whole grain, is subsequently added relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder
Mixture, 5 weight portion magnesium stearates, it is then charged in gelatine capsule.
Toxicity test:
Acute toxicity testing: application mouse 60, male and female half and half, body weight 20-38g, carries out acute poison
Property test.Mouse is randomly divided into two groups, i.e. control group and administration group, fasting 12 hours before experiment, incite somebody to action this
The Chinese medicinal tablet of inventive embodiment 1 preparation is dissolved in water, and (concentration is 8.44g crude drug/ml, the highest
Concentration) gavage, gavage volume is 5ml/kg (i.e. unit dosage form is 42.2 crude drugs/kg), comparison
Group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, sees continuously after administration
Examine 14 days, and record mouse toxic reaction and death toll.Test result indicate that: compare with control group,
After administration, mouse has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water,
Body weight increases the most normal.Tablet LD50 > 42.2 crude drugs/the kg of the Mouse oral gavage present invention, every day is maximum
Dosage is 84.4 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention is 8.06g crude drug/day/people,
Adult's body weight is in terms of 60KG, and average dosage is 0.134g crude drug/kg/ day.By batheroom scale: mouse
As quantity 630 times of the dosis tolerata of the Chinese medicine of (average weight is in terms of 29g) oral administration gavage present invention.
Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: three groups of mouse (often group 20) are pressed by Chinese medicine embodiment 1 tablet of the present invention
14.16,27.38 and 41.59g crude drugs/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2
Secondary) and drug withdrawal 3 weeks after, result shows: Chinese medicine of the present invention is to the hair of mouse, behavior, stool and urine, body
The indexs such as weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat all have no significant effect, internal organs meat
Eye does not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, and mouse
Each internal organs are all without substantially changing.Illustrate that Chinese medicine of the present invention is little, after drug withdrawal also to toxicity after mouse long-term prescription
There is no difference reaction, application safety.
Clinical data:
Case selection: all 102 example cases derive from this Out-patient Department and the Cholestatic hepatitis being in hospital
Patient, is randomly divided into two groups, treatment group and each 51 example patients of control group.In treatment group 51 example patient,
Man's 23 examples, female 28 example；Age 25～73 years old；The course of disease 1～8 months.Control group 51 example patient, man
22 examples, female 29 example；Age 22～69 years old；The course of disease 1～7.5 months.Treatment group and control group are in property
Not, age, the aspect such as the course of disease and clinical symptoms compare no significant difference, there is comparativity.
Diagnostic criteria: 1, patient is presented with jaundice, urine color depth such as black tea, stool lighter even potter's clay
Look, and the Symptoms last such as corresponding simultaneous phenomenon such as fatigue, pruitus more than 3 weeks.2, liver function
Check that display serum bilirubin is significantly raised, based on bilirubin direct.3, with SBA, alkali
Acid phosphatase (ALP), gamma glutamyl transpeptidase (GGT) are significantly raised.4, B ultrasonic, CT, magnetic are common
The imaging examination such as imaging or endoscopic retrograde cholangiopancreaticography that shakes gets rid of Changes of Liver in Obstructive Jaundice.
Methods for the treatment of:
Control group: oral Ursodeoxycholic Acid Tablets, each 3 (150mg), three times a day；Oral administered compound
Glycyrrhizin sheet, each 2, three times a day；Reduced glutathione parenteral solution 1.8g adds 5% Portugal
Grape sugar parenteral solution 250ml iv drip, every day 1 time.It within 1 month, it is 1 course for the treatment of.
Treatment group: on the basis for the treatment of of control group, is administered orally Chinese medicine embodiment 1 tablet of the present invention, often simultaneously
Secondary 2, three times a day；It within 1 month, it is 1 course for the treatment of.
Curative effect judging standard: effective: clinical symptoms and sign disappear or substantially disappear, and liver function is the most extensive
Multiple normal or close normal, bilirubin direct declines more than 60%.(2) effective: clinical symptoms and sign
Being clearly better, liver function indices declines in various degree, and bilirubin direct declines more than 30%.(3)
Invalid: clinical symptoms and sign are all without being clearly better or increasing the weight of, and liver function is not improved or increases the weight of, courage
Red pigment is without being clearly better or increasing the weight of.
Treatment results: after two groups are treated 30 days respectively, statistics sees table 1.
Clinical efficacy comparison (unit: example) after treating 45 days respectively organized by 1 liang of table
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 51 | 40 | 8 | 3 | 48 (94.12%) |
| Control group | 51 | 29 | 13 | 9 | 42 (82.35%) |
As it can be seen from table 1 treatment group uses the Chinese medicine of the present invention, coordinate western medical treatment cholestatic
Hepatitis, relative to control group, in result for the treatment of, has and is markedly improved.
Bad reaction: liver and kidney dysfunction does not all occur in two groups of patient treatment procedure or other are the worst
Reaction.
Concrete case: Wu, man, 60 years old, makes a definite diagnosis existing 4 of Cholestatic hepatitis in other hospitals
Month, result for the treatment of is undesirable, sees a doctor to the court.Patient does not moves back the jaundice several months, and pruitus has after grabbing
Tiny blutpunkte and ecchymosis, urine is deep yellow, and stool discoloration is shallow.Hepatomegaly.Slightly feel weak, pharyngoxerosis.
It is cholestatic pneumonia through clinical definite.Ursodeoxycholic Acid Tablets is taken to lymphogranuloma inguinale, each 3 (150mg),
Three times a day；Oral administered compound glycyrrhizin sheet, each 2, three times a day；Reduced glutathione is noted
Penetrate liquid 1.8g and add 5% glucose injection 250ml iv drip, every day 1 time.This is administered orally simultaneously
Invention Chinese medicine embodiment 1 tablet, each 2, three times a day；Treat 1 month, clinical symptoms and body
Levying and be wholly absent, liver function recovers normal substantially, and bilirubin direct declines about 81%；Effective.
All above-mentioned primary implement these intellectual properties, do not set limit other forms enforcement this
Plant new product or new method.Those skilled in the art will utilize this important information, and foregoing is revised,
To realize similar implementation status.But, all modifications or transformation belong to reservation based on new product of the present invention
Right.
The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form
Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above
Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on
Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention,
Still fall within the protection domain of technical solution of the present invention.
Claims (8)
1. the Chinese medicine treating Cholestatic hepatitis, it is characterised in that described Chinese medicine includes following former
Material medicinal material: black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb, Chinese box root, Herba Aeluropi sinensis,
Japanese rose root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, conespike flemingia root, japanese xylosma root, bittersweet, go to the field
Chrysanthemum, herba fibraureae recisae, cat flower, high mallow, corridor mattress, rock pine and stone banyan.
2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of described raw medicinal material
For: black brave 7 20～30 parts, elaeagnus conferta fruits 15～25 parts, common vetch seed 10～20 parts, bitter bamboo shoot 15～30
Part, indian glorybower herb 30～40 parts, Chinese box root 10～25 parts, Herba Aeluropi sinensis 5～15 parts, japanese rose root 10～
20 parts, another name for Sichuan Province slender acanthopanax 15～25 parts, cushaw root 15～30 parts, swamp eel rattan 20～35 parts, conespike flemingia root 5～
15 parts, japanese xylosma root 15～25 parts, bittersweet 20～30 parts, adenostemma laveniaKuntze 10～25 parts, herba fibraureae recisae
30～40 parts, cat spend 15～30 parts, high mallow 10～25 parts, corridor mattress 5～15 parts, rock pine 15～25
Part and stone banyan 10～20 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the weight portion of described raw medicinal material
Number ratios be: black brave 7 25～30 parts, elaeagnus conferta fruits 15～20 parts, common vetch seed 10～15 parts, bitter bamboo shoot 20～
25 parts, indian glorybower herb 35～40 parts, Chinese box root 15～20 parts, Herba Aeluropi sinensis 10～15 parts, rose
Root 15～20 parts, another name for Sichuan Province slender acanthopanax 20～25 parts, cushaw root 25～30 parts, swamp eel rattan 30～35 parts, freshwater mussel
Shell grass roots 5～10 parts, japanese xylosma root 15～20 parts, bittersweet 25～30 parts, adenostemma laveniaKuntze 15～20
Part, herba fibraureae recisae 30～35 parts, cat spend 20～25 parts, high mallow 15～20 parts, corridor mattress 5～10 parts, rock pine
20～25 parts and stone banyan 15～20 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the weight portion of described raw medicinal material
Number ratios be: black brave 7 26 parts, elaeagnus conferta fruits 19 parts, common vetch seed 12 parts, bitter bamboo shoot 25 parts, long tube vacation jasmine
Jasmine 36 parts, Chinese box root 18 parts, Herba Aeluropi sinensis 12 parts, japanese rose root 19 parts, another name for Sichuan Province slender acanthopanax 21 parts, cushaw root
29 parts, 32 parts of swamp eel rattan, conespike flemingia root 10 parts, japanese xylosma root 16 parts, bittersweet 28 parts, under
Field chrysanthemum 16 parts, herba fibraureae recisae 35 parts, cat spend 21 parts, high mallow 19 parts, 7 parts of corridor mattress, rock pine 25 parts and stone
Banyan 19 parts.
5. the Chinese medicine as described in Claims 1-4, it is characterised in that the formulation of described Chinese medicine is tablet,
Its preparation method comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb, Chinese box root, horse
Stumble grass, japanese rose root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan and conespike flemingia root mixes in proportion, add relative to
3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% extract 2 times～4 times, and each 2
Hour～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into 70 DEG C of relative densities be 1.30～
The lotion of 1.32, standby；
Second step, mixes in proportion by surplus stock medicinal material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the lotion mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum are dried,
Get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains lotion mixture；Described
Lotion and the weight ratio of starch be 1: 0.01～0.02；Described lotion mixture is carried out pelletization treatment,
It is dried and processes, the lotion compound particles obtained；
5th step, is carried out at mixing successively by described lotion compound particles and talcum powder, magnesium stearate
Reason, compressing tablet process, Cotton seeds, obtain Chinese medicinal tablet finished product；Described particle, talcum powder, tristearin
The weight ratio of acid magnesium is 100: 1～3: 0.15～0.3.
6. the Chinese medicine as described in Claims 1-4, it is characterised in that the formulation of described Chinese medicine is capsule
Agent, its preparation method comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb and Chinese box root by institute
State ratio mixing, add and extract volatile oil, by the volatile oil β of acquisition relative to the water of mixture 4～6 times
-cyclodextrin encapsulated, volatile oil is 1: 3～6 with the ratio of beta-schardinger dextrin, stirs 75 minutes～90 minutes,
Temperature 30 DEG C～50 DEG C, obtains volatile oil clathrate compound, standby；Separately aqueous extract is concentrated into when 60 DEG C relative
Density is the clear cream of 1.15～1.17；
Second step, by another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, japanese xylosma root, bittersweet, adenostemma laveniaKuntze and
Cat flower is mixed in described ratio, adds relative to the ethanol that mixture 6～8 times amount determining alcohol is 80%～90%
Refluxing extraction 3～5 times, each 2～3 hours, filter, and filtrate merges, and reclaims ethanol, is concentrated into 60 DEG C
Time relative density be 1.20～1.22 clear cream, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10
Times amount water, boils 6～8 hours, filter, when being concentrated into 60 DEG C relative density be 1.28～1.30 clear
Cream；
4th step, mixes the clear cream of the first step, second step, the 3rd step, 60 DEG C～70 DEG C of reduced vacuum
Being dried, get dry extract powder；
5th step, is sufficiently mixed dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, with
Rear addition is relative to volatile oil clathrate compound described in 100 weight portions and the mixture of dried cream powder, 5～8 weight portions
Sodium carboxymethyl starch, 10～50 weight starch mix, add 150～200 weight portion determining alcohols
It is 80%～90% alcohol granulation, is dried, whole grain, is subsequently added relative to volatile oil described in 100 weight portions
Inclusion compound and the mixture of dried cream powder, 3～5 weight portion magnesium stearates, it is then charged in gelatine capsule.
7. the preparation method of the Chinese medicine described in a Claims 1-4, it is characterised in that described Chinese medicine
Formulation be tablet, it comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb, Chinese box root, horse
Stumble grass, japanese rose root, another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan and conespike flemingia root mixes in proportion, add relative to
3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% extract 2 times～4 times, and each 2
Hour～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into 70 DEG C of relative densities be 1.30～
The lotion of 1.32, standby；
Second step, mixes in proportion by surplus stock medicinal material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the lotion that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the lotion mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum are dried,
Get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains lotion mixture；Described
Lotion and the weight ratio of starch be 1: 0.01～0.02；Described lotion mixture is carried out pelletization treatment,
It is dried and processes, the lotion compound particles obtained；
5th step, is carried out at mixing successively by described lotion compound particles and talcum powder, magnesium stearate
Reason, compressing tablet process, Cotton seeds, obtain Chinese medicinal tablet finished product；Described particle, talcum powder, tristearin
The weight ratio of acid magnesium is 100: 1～3: 0.15～0.3.
8. the preparation method of the Chinese medicine described in a Claims 1-4, it is characterised in that described Chinese medicine
Formulation be capsule, its preparation method comprises the following steps:
The first step, by black brave seven, elaeagnus conferta fruits, common vetch seed, bitter bamboo shoot, indian glorybower herb and Chinese box root by institute
State ratio mixing, add and extract volatile oil, by the volatile oil β of acquisition relative to the water of mixture 4～6 times
-cyclodextrin encapsulated, volatile oil is 1: 3～6 with the ratio of beta-schardinger dextrin, stirs 75 minutes～90 minutes,
Temperature 30 DEG C～50 DEG C, obtains volatile oil clathrate compound, standby；Separately aqueous extract is concentrated into when 60 DEG C relative
Density is the clear cream of 1.15～1.17；
Second step, by another name for Sichuan Province slender acanthopanax, cushaw root, swamp eel rattan, japanese xylosma root, bittersweet, adenostemma laveniaKuntze and
Cat flower is mixed in described ratio, adds relative to the ethanol that mixture 6～8 times amount determining alcohol is 80%～90%
Refluxing extraction 3～5 times, each 2～3 hours, filter, and filtrate merges, and reclaims ethanol, is concentrated into 60 DEG C
Time relative density be 1.20～1.22 clear cream, standby；
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10
Times amount water, boils 6～8 hours, filter, when being concentrated into 60 DEG C relative density be 1.28～1.30 clear
Cream；
4th step, mixes the clear cream of the first step, second step, the 3rd step, 60 DEG C～70 DEG C of reduced vacuum
Being dried, get dry extract powder；
5th step, is sufficiently mixed dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, with
Rear addition is relative to volatile oil clathrate compound described in 100 weight portions and the mixture of dried cream powder, 5～8 weight portions
Sodium carboxymethyl starch, 10～50 weight starch mix, add 150～200 weight portion determining alcohols
It is 80%～90% alcohol granulation, is dried, whole grain, is subsequently added relative to volatile oil described in 100 weight portions
Inclusion compound and the mixture of dried cream powder, 3～5 weight portion magnesium stearates, it is then charged in gelatine capsule.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425417A (en) * | 2002-12-27 | 2003-06-25 | 支金华 | Medicine for dispelling heat of liver and toxin to treat hepatitis B |
| CN1879845A (en) * | 2006-04-07 | 2006-12-20 | 成都万芳科技发展有限公司 | A pharmaceutical composition for preventing or treating acute and chronic liver disease |
| CN103550513A (en) * | 2013-10-23 | 2014-02-05 | 陈英娣 | Traditional Chinese medicine for treating cholestatic hepatitis |
| CN105435165A (en) * | 2015-12-03 | 2016-03-30 | 葛秀娟 | Traditional Chinese medicine for treating cluster headache in anesthesia department and preparing method thereof |
| CN105434963A (en) * | 2016-01-01 | 2016-03-30 | 谢文贵 | Traditional Chinese medicine preparation for treating tuberculosis of bone and joint and preparation method for traditional Chinese medicine preparation |
| CN105497724A (en) * | 2016-01-22 | 2016-04-20 | 赵鲁东 | Traditional Chinese medicine preparation for treating cholelithiasis and preparation method thereof |
| CN105521335A (en) * | 2016-01-07 | 2016-04-27 | 李涛 | Traditional Chinese medicine for treating paroxysmal supraventricular tachycardia and preparation method of traditional Chinese medicine |
-
2016
- 2016-05-27 CN CN201610367344.5A patent/CN105853806A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425417A (en) * | 2002-12-27 | 2003-06-25 | 支金华 | Medicine for dispelling heat of liver and toxin to treat hepatitis B |
| CN1879845A (en) * | 2006-04-07 | 2006-12-20 | 成都万芳科技发展有限公司 | A pharmaceutical composition for preventing or treating acute and chronic liver disease |
| CN103550513A (en) * | 2013-10-23 | 2014-02-05 | 陈英娣 | Traditional Chinese medicine for treating cholestatic hepatitis |
| CN105435165A (en) * | 2015-12-03 | 2016-03-30 | 葛秀娟 | Traditional Chinese medicine for treating cluster headache in anesthesia department and preparing method thereof |
| CN105434963A (en) * | 2016-01-01 | 2016-03-30 | 谢文贵 | Traditional Chinese medicine preparation for treating tuberculosis of bone and joint and preparation method for traditional Chinese medicine preparation |
| CN105521335A (en) * | 2016-01-07 | 2016-04-27 | 李涛 | Traditional Chinese medicine for treating paroxysmal supraventricular tachycardia and preparation method of traditional Chinese medicine |
| CN105497724A (en) * | 2016-01-22 | 2016-04-20 | 赵鲁东 | Traditional Chinese medicine preparation for treating cholelithiasis and preparation method thereof |
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