CN104256168B - One boar functional feed and preparation method thereof - Google Patents

One boar functional feed and preparation method thereof Download PDF

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CN104256168B
CN104256168B CN201410504278.2A CN201410504278A CN104256168B CN 104256168 B CN104256168 B CN 104256168B CN 201410504278 A CN201410504278 A CN 201410504278A CN 104256168 B CN104256168 B CN 104256168B
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吕尊周
吕明斌
燕磊
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Jiangmen six and Feed Co., Ltd.
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Shandong New Hope Liuhe Group Co Ltd
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Abstract

The invention discloses a boar functional feed, it is characterized in that, described feed comprises following raw material: corn, glutinous rice, dregs of beans, peanut meal, lotus root starch, fish meal, seawood meal, honey, the egg boiling, vegetable oil, salt and vitamin premix. The invention has the beneficial effects as follows: feed of the present invention is applicable to suffer from the ill pig of contagious pleuropneumonia, not only can treat contagious pleuropneumonia, but also can meet the nutritional need of pig, maintains normal production performance.

Description

One boar functional feed and preparation method thereof
Technical field
The present invention relates to field of feed, relate in particular to boar functional feed and preparation method thereof.
Background technology
Porcine contagious pleuropneumonia is a kind of contagious disease being caused by Actinobacillus pleuropneumoniae, is the one of pigImportant breathing problem, popular in many countries of raising pigs, become one of five large epidemic diseases that worldwide industrialization raises pigs, cause weightLarge economic loss. Antibiotic to this disease without obvious curative effects. Although this disease and pathogen thereof have been done to extensive and deep grindingStudy carefully, on vaccine and diagnostic method, obtained certain achievement, but up to the present, also do not have effectively measure control originallySick.
Pathogen is pleuropneumonia actinomyces (original name pleuropneumonia haemophilus, also claims haemophilus parahaemolyticus), for littleTo medium sized club shape to shaft-like, there is significant polymorphy. Thalline has pod membrane, do not move, and Gram-negative. For facultativeAnaerobic bacteria, the growth factor in its growth needs blood, particularly the V factor, but can not on blood agar medium, grow, can beStaphylococcus around forms satellite colony, therefore, while separating this bacterium for the first time, must be on blood agar culture-medium standardized grapeCoccus line, cultivates after 24 hours for 37 DEG C, and near bacterium colony size staphylococcus bacterium colony is 0.5~1 millimeter and is β haemolysis.At the upper well-grown of chocolate agar (blood agar heating 80~90 DEG C 5~15 minutes and make), cultivate 24~48 little for 37 DEG CShi Hou, grows up to the greyish white translucent petite of circle, protuberance, smooth surface, neat in edge. On plain agar, do not grow. RootCarry out serum sizing according to bacterial capsule polysaccharide and bacteria lipopolysaccharide (LPS), this bacterium has been found 12 serotypes, and wherein 5 types divide againBe 2 hypotypes, the virulence difference of different serotype to pig. This bacterium resistance is to external world not strong, in dry situation, is easy toDeath, to conventional disinfectant sensitivity, general 60 DEG C dead in 5~20 minutes, survival 7~10 days conventionally at 4 DEG C.
The generation of this disease is acute or the acute course of disease and dead rapidly more, acute swinery, the incidence of disease and dead of breaking outThe rate of dying is generally 50% left and right, and the death rate of acute can reach 80%~100%.
Sick pig and the pig that carries disease germs are this sick infections sources. Herd boar and chronic infection pig play very important in this disease of propagationEffect. APP is mainly by air droplet transmission, is cause of disease at positions such as nose juice, tonsillotome, bronchus and the lungs of infected pigsThe main place that bacterium exists, germ forms the spittle after discharging with the approach such as breathing, cough, sneeze, by direct contact through exhalingSuction road is propagated. Also can be by by the vehicle of pathogen contamination, utensil and keeper's clothing etc. and indirect contact transmission. LittleRodent and bird also may be propagated this disease.
This disease there is obvious seasonality, be multiplely born in 4~May and 9~November. Feeding environment flip-flop,The stress factor such as the transfer of swinery or mixed group, crowded or long-distance transport, improper ventilation, humidity are too high, temperature cataclysm, all can causeThis disease occurs or accelerates transmission, and M & M is increased.
Be about 1~7 day or longer the incubation period of artificial challenge pig. Due to age of animal, immune state, environmental factor withAnd the difference of the infection quantity of cause of disease, face the course of disease of examining morbidity pig and can be divided into acute, acute, subacute type and chronicType. Major lesions is present in lung and respiratory tract, and lung is aubergine, and mostly pneumonia is bilateral, and how at lobus cardiacus, the point of lungLeaf and occur focus every leaf, the division is clearly demarcated for itself and normal structure. In the sick pig tracheae of acute death, bronchus, be full of foamShape, courageous and upright mucus and mucous membrane exudate, cellulose-less tuberculous pleurisy occurs. 24 hours above sick pigs fall ill. Pneumonia district occursFiber disposition material invests surface, empsyxis, interstitial broadening, have liver become. In tracheae, bronchus, be full of foam-like, courageous and upright mucusAnd mucous membrane exudate, larynx is full of bloody fluid, the remarkable enlargement of hilar lymph node. Along with the development of the course of disease, fiber disposition pleuraInflammation spreads to whole lungs, makes lung and pleaural adhesion. The pericarditis that often occurs together, liver, splenomegaly, subduing. It is chronic that the course of disease is grownCase, visible strong pneumonia district, focus sclerosis or downright bad. In the later stage of morbidity, sending out appears in nose, ear, eye and the rear quarters skin of sick pigDark purple, is purple plague purpura.
The at present treatment Western medicine that adopt are treated more, as penicillin, neomycin, tetracycline, Tiamulin, tylosin,Sulfamido etc. Although report that many antibiotic are effective, due to the drug resistance of bacterium, this sick clinical therapeutic efficacy is not obvious. InAnimal doctor thinks, pig transmissible pleura pneumonia is the outer evil lung of violating, due to sluggishness of lung-QI is smooth, its pathological factor be wind, cold, heat,Wet, dry, fiery, in pathological process, can there is chill heat-transmission, wind-heat dryness-transformation, or lung heat steaming liquid becomes the pathology such as phlegm to transform. Chinese traditional treatmentPig transmissible pleura pneumonia diagnosis and treatment, from entirety, treats short treating period, takes effect the ill pig of same disease typeHurry up, have no side effect, drug residue free amount, and can improve body disease-resistant power, the immunity etc. of ill pig, and medicinal material becomesThis is cheap, and manufacture craft is easy etc.
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of contain be used for the treatment of porcine contagious pleuropneumonia inPig functional feed of medicine additive and preparation method thereof, this Chinese medicine additive utilizes Traditional Chinese medical theory, taking Overall View as basePlinth, controls as instructing with dialectical opinion, taking clearing heat-fire, removing toxic substances, cough-relieving as primary treatment principle, regulates the flow of vital energy as auxiliary taking invigorating the spleen, and treatment pigThat contagious pleuropneumonia has is rapid-action, determined curative effect, safe, the advantage that has no side effect.
In order to solve the problems of the technologies described above, the invention provides a kind of the functional of porcine contagious pleuropneumonia that be used for the treatment ofFeed, wherein, described feed comprises following raw material: corn, glutinous rice, dregs of beans, peanut meal, lotus root starch, fish meal, seawood meal, honey, boilRipe egg, vegetable oil, salt and vitamin premix.
In described feed, the parts by weight of each raw material are: corn 50-80 weight portion, glutinous rice 40-70 weight portion, dregs of beans 20-30 weight portions, peanut meal 15-25 weight portion, lotus root starch 20-44 weight portion, fish meal 10-26 weight portion, seawood meal 15-27 weight portion,Honey 5-8 weight portion, the egg 8-12 weight portion boiling, vegetable oil 5-7 weight portion, salt 1-5 weight portion and vitamin are pre-Batch mixing 0.1-0.5 weight portion.
Described feed also comprises Chinese medicine additive, and in described feed, the parts by weight of each raw medicinal material are: corn 50-80 is heavyAmount part, glutinous rice 40-70 weight portion, dregs of beans 20-30 weight portion, peanut meal 15-25 weight portion, lotus root starch 20-44 weight portion, fish meal10-26 weight portion, seawood meal 15-27 weight portion, honey 5-8 weight portion, the egg 8-12 weight portion, the vegetable oil 5-7 that boilWeight portion, salt 1-5 weight portion, vitamin premix 0.1-0.5 weight portion and Chinese medicine additive 1-7 weight portion.
In described feed, the parts by weight of each raw medicinal material are: corn 77 weight portions, glutinous rice 65 weight portions, dregs of beans 26 weightPart, peanut meal 21 weight portions, lotus root starch 32 weight portions, fish meal 19 weight portions, seawood meal 23 weight portions, honey 6 weight portions, boilEgg 10 weight portions, vegetable oil 6 weight portions, salt 3 weight portions, vitamin premix 0.3 weight portion and Chinese medicine additive 4 weightsAmount part.
Described Chinese medicine additive comprises following raw medicinal material: golden cypress, the root of large-flowered skullcap, cordate houttuynia, honeysuckle, the root bark of tree peony, marine alga stone, dryGinger, almond, blue gum, cape jasmine, the dried rhizome of rehmannia, ivy glorybind, Fermented Soybean, reed rhizome, Chinese holly, rib leaf fragrant-flowered garlic, beggar-ticks, kalimeris, pears skin, pen shellShell, Snakegourd Fruit, dried mushroom, tussilago, rose, radish seed, card Mi, Han dish, Perilla frutescens, balloonflower root, Fructus Hordei Germinatus and Hericium erinaceus.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: golden cypress 20-30 weight portion, root of large-flowered skullcap 10-15 weightPart, cordate houttuynia 10-20 weight portion, honeysuckle 15-30 weight portion, root bark of tree peony 10-20 weight portion, marine alga stone 10-15 weight portion, rhizoma zingiberis20-30 weight portion, almond 15-30 weight portion, blue gum 10-20 weight portion, cape jasmine 10-15 weight portion, dried rhizome of rehmannia 10-20 weight portion,Ivy glorybind 10-20 weight portion, Fermented Soybean 10-25 weight portion, reed rhizome 20-30 weight portion, Chinese holly 10-25 weight portion, rib leaf fragrant-flowered garlic10-15 weight portion, beggar-ticks 10-20 weight portion, kalimeris 10-15 weight portion, pears skin 10-20 weight portion, pen shell shell 10-25 weightPart, Snakegourd Fruit 10-20 weight portion, dried mushroom 10-15 weight portion, tussilago 10-25 weight portion, rose 10-25 weight portion, radish seed10-15 weight portion, block close 10-25 weight portion, Han dish 10-20 weight portion, Perilla frutescens 10-25 weight portion, balloonflower root 10-20 weightPart, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 10-15 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: golden cypress 22-28 weight portion, root of large-flowered skullcap 10-15Weight portion, cordate houttuynia 15-18 weight portion, honeysuckle 20-25 weight portion, root bark of tree peony 14-18 weight portion, marine alga stone 10-15 weight portion,Rhizoma zingiberis 23-28 weight portion, almond 20-25 weight portion, blue gum 15-17 weight portion, cape jasmine 12-14 weight portion, dried rhizome of rehmannia 14-16 weightPart, ivy glorybind 15-18 weight portion, Fermented Soybean 15-20 weight portion, reed rhizome 25-27 weight portion, Chinese holly 15-20 weight portion, rib leafFragrant-flowered garlic 10-15 weight portion, beggar-ticks 13-17 weight portion, kalimeris 11-13 weight portion, pears skin 15-17 weight portion, pen shell shell 15-20 weighAmount part, Snakegourd Fruit 12-17 weight portion, dried mushroom 11-14 weight portion, tussilago 15-20 weight portion, rose 15-20 weight portion, radishSub-12-14 weight portion, block close 15-20 weight portion, Han dish 15-17 weight portion, Perilla frutescens 15-20 weight portion, balloonflower root 15-18 weightPart, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 12-15 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: each former in described pharmaceutical compositionThe parts by weight of material medicinal material are: golden cypress 25 weight portions, the root of large-flowered skullcap 13 weight portions, cordate houttuynia 16 weight portions, honeysuckle 23 weight portions, pelletSkin 16 weight portions, marine alga stone 13 weight portions, rhizoma zingiberis 25 weight portions, almond 23 weight portions, blue gum 16 weight portions, cape jasmine 13 weightPart, the dried rhizome of rehmannia 15 weight portions, ivy glorybind 16 weight portions, Fermented Soybean 18 weight portions, reed rhizome 26 weight portions, Chinese holly 17 weight portions, ribLeaf fragrant-flowered garlic 13 weight portions, beggar-ticks 15 weight portions, kalimeris 12 weight portions, pears skin 16 weight portions, pen shell shell 17 weight portions, Snakegourd Fruit 14 weightsAmount part, dried mushroom 13 weight portions, tussilago 17 weight portions, rose 17 weight portions, radish seed 13 weight portions, block close 18 weight portions,Han dish 16 weight portions, Perilla frutescens 17 weight portions, balloonflower root 16 weight portions, Fructus Hordei Germinatus 13 weight portions and Hericium erinaceus 14 weight portions.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, and adding with respect to the determining alcohol of 4~8 times, mixture is 85%~95% ethanol, is heated to boiling reflux 3~5 hours, filters, and adopts percolation slowly to ooze with the speed of 1~2ml per minuteFilter, collect percolate, while being evaporated to 50~60 DEG C subsequently under vacuum 0.06~0.09Mpa relative density be 1.04~1.10 lotion, spraying is dry, and 160~175 DEG C of the EATs of spray dryer, 80~85 DEG C of leaving air temps are pulverized subsequentlyPowdered, makes dried cream powder;
Second step: in the dried cream powder obtaining, add cane sugar powder and 0.1 with respect to 0.2~0.4 times of dried cream powder quality~The dextrin of 0.2 times, granulation, in 40~50 DEG C dry, obtain Chinese medicine additive.
In order better to realize foregoing invention object, the invention provides the preparation method of a boar functional feed, instituteStating preparation method comprises the following steps:
(1) pulverising step: take all raw materials according to parts by weight, drop into pulverizer and pulverize, grinding particle size is1.5mm;
(2) blend step: raw material and surplus stock after step (1) is pulverized drop into mixer, mix, when mixingBetween be 3-5 minute;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 75-85 DEG C.
Beneficial effect of the present invention is: feed of the present invention is applicable to suffer from the ill pig of contagious pleuropneumonia, can not onlyEnough treat contagious pleuropneumonia, but also can meet the nutritional need of pig; The Chinese medicine additive utilization containing in feedTraditional Chinese medical theory, taking Overall View as basis, controls as instructing with dialectical opinion, taking clearing heat-fire, removing toxic substances, cough-relieving as primary treatment former, regulate the flow of vital energy as auxiliary taking invigorating the spleen, treatment porcine contagious pleuropneumonia have rapid-action, determined curative effect, safe, have no side effectAdvantage; Itself and other raw material cooperatively interacts, and acting in conjunction can improve the resistance against diseases of ill pig, safeguards the life of ill pigProduce performance.
Detailed description of the invention
Chinese veterinarian thinks and a kind of hyperinfection breathing problem of porcine contagious pleuropneumonia is called again pig contagious infectionProperty pleuropneumonia. Taking acute hemorrhagic fiber disposition pleuropneumonia and chronic fiber disposition gangrenosum acne pleuropneumonia as feature, anxiousSexual type presents high mortality. Porcine contagious pleuropneumonia is a kind of worldwide disease, is distributed widely in Britain, Germany, Switzerland, pelletThe all states of raising pigs in the whole world such as wheat, Australia, Canada, Mexico, Argentina, Sweden, Poland, Japan, the U.S., ChinaFamily, causes huge economic loss to intensive industrialized piggery, and particularly this disease popular in rising trend in recent ten years, by stateBorder is known as one of important epidemic disease of harm Pig Industry industry. After this China found this disease first in 1987, ran rampant outCome, harm is on the rise, and becomes one of main epidemic disease of pig bacterial respiratory tract disease.
Therefore, the invention provides a kind of the raising of Chinese medicine additive that is used for the treatment of pig transmissible pleura pneumonia of containingMaterial, Chinese medicine additive, taking clearing heat-fire, removing toxic substances, cough-relieving as primary treatment principle, is regulated the flow of vital energy as auxiliary taking invigorating the spleen, selects prescription: golden cypress,The root of large-flowered skullcap, cordate houttuynia, honeysuckle, the root bark of tree peony, marine alga stone, rhizoma zingiberis, almond, blue gum, cape jasmine, the dried rhizome of rehmannia, ivy glorybind, Fermented Soybean, reed rhizome, fourJi Qing, rib leaf fragrant-flowered garlic, beggar-ticks, kalimeris, pears skin, pen shell shell, Snakegourd Fruit, dried mushroom, tussilago, rose, radish seed, card are close, Han dish,Perilla frutescens, balloonflower root, Fructus Hordei Germinatus and Hericium erinaceus.
Wherein, the pharmacology of above-mentioned raw materials medicinal material is as follows:
Golden cypress: be the dry bark of rutaceae wampee or cork tree. The former practises title " CORTEX PHELLODENDRI CHINENSE ", and the latter practises title " closesGolden cypress ". Can be used as medicine, nature and flavor bitter cold, has heat-clearing and damp-drying drug, and purging intense heat is except steaming, effect of detoxification sore treatment. Cork tree be distributed in Northeast China andThe areas such as North China each province, happiness grows among mountain area, assorted woods, and strong adaptability is applicable to sun-drenched local cultivation, also can resist tightCold. Golden cypress is conventional Chinese medicine, its cold in nature, bitter, the effects such as tool heat-clearing and damp-drying drug, purging intense heat and detonicating, be usually used in damp-heat dysentery, jaundice,The diseases such as leukorrhea and hot numbness, heat pouring. Modern study shows, golden cypress is containing main components such as berberine, obakunones, have antibacterial, convergence,The effect of anti-inflammatory, to symptoms such as the wet poison of various skin, sores, effect is good. " herbal classic is met former " said: " golden cypress, raw with falling excess fire,Wine system is controlled on yin fire scorching, and salt system is controled the inferior Jiao's fire, and ginger system is controlled middle burnt convulsive seizure due to phlegm-fire, and ginger juice stir-fry is black to be controlled damp and hotly, and salt wine is fried the black fire of deficiency type processed, the moonThe fire of deficiency type is contained flushing floating yang, monkshood juice system ".
The root of large-flowered skullcap: property hardship, cold. Return lung, courage, spleen, large intestine, small intestinl channel. " book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, radix bupleuri the best, soCan not reach table by cool flesh without the root of large-flowered skullcap. The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so gives up the root of large-flowered skullcap and can not go up refresh oneself. So Fang Mai section with clear fleshBring down a fever, speciality of carbuncle and ulcers with detoxify and promote granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, Ci Gaizhu section half table halfIn first of agent also. " can heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive. For damp-warm syndrome, the heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffianFull, rush down dysentery, jaundice, cough with lung heat, high hot polydipsia, blood-head is told nosebleed, carbuncle sore tumefacting virus, fetal irritability. That the root of large-flowered skullcap has is antipyretic, calm, fallThe effects such as blood pressure, diuresis, reduction capillary permeability, inhibition intestinal tube wriggling, to staphylococcus, blood dissolubility streptococcus, pneumoniaDiplococcus, typhoid bacillus, dysentery coccus, ewcastle disease, Pseudomonas aeruginosa have certain inhibitory action, to the infection of the upper respiratory tract, slowProperty bronchitis, bacillary dysentery etc. have good curative effect.
Cordate houttuynia: cold nature, bitter. Return lung channel, bladder, large intestine channel. Have clearing heat and detoxicating; Removing pus and relieving carbuncle; Inducing diuresis for treating strangurtiaFunction. Cure mainly heat and drench main lung carbuncle pyemesis; Phlegm heat panting is coughed; Larynx; Hot dysentery; Carbuncle sore tumefacting virus; Heat is drenched. Effect: clearing heat and detoxicating, diuresisDetumescence. Control pneumonia, lung abscess, hot dysentery, malaria, oedema, gonorrhoea, leukorrhea, carbuncle is swollen, hemorrhoid, prolapse of the anus, eczema, the favus of the scalp, mange. ExistingFor the multiplex lung abscess of controlling, pneumonia, acute and chronic tracheitis, urinary tract infections etc. Modern pharmacology is tested and is shown, it is antibacterial, anti-that these product haveThe effects such as virus, raising immunity of organisms, diuresis. Clinical report is widely used in treatment pneumonia, spitting of blood, the infection of the upper respiratory tract, slowProperty bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, lung cancer, cervical erosion, pyogenic arthritis, habitInertia constipation, acute bacillary dysentery, acute icterohepatitis, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurationProperty tympanitis, mumps, papule shape nettle rash, chronic pharyngitis, anus enteropathy, prostatitis, lupus erythematosus, hemangioma,Prevention leptospirosis etc.
Honeysuckle: cold in nature, taste is sweet, enters lung, the heart, stomach warp, has clearing heat and detoxicating, anti-inflammatory, qi-restoratives and treat effect of wind, cures mainly swollenCompletely descend disease, warm disease heating, the diseases such as hot malicious large carbuncle and tumour. Its for dizzy dizzy, dry do thirsty, hidrosis is unhappy, enteritis, bacteriumDysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin infection, ulcer furunculosis, erysipelas, the parotid glandThe illnesss such as inflammation, suppurative tonsillitis all have certain curative effect. Lonicera flower tea has unique weight losing function simultaneously, can also suppress and killThe go out pathogen of bottleneck throat, has anti-infective effect to old man and children. So, often take honeysuckle immersion or decoction and be conducive toWind fire hot eyes, abscess of throat, obesity, liver heat symptom-complex and the hypertensive treatment of liver pattern of fever and rehabilitation. The warm disease initial stage: normal with; The capsule of weeping forsythia,Peppermint, tasteless preserved soybean are equal to use, have clearing heat and detoxicating, expelling wind to resolve the exterior effect, can be in order to the warm disease initial stage, and heating slight chill chill, mouthfulMicro-thirsty, as Yinqiao San. Ulcer serious case of furuncle: normal and dandelion, Herba Violae, mother chrysanthemum are equal to use, can strengthen antipyretic and antidote functions, availableWith ulcer serious case of furuncle, congestion and swelling pain, as wuwei xiaodu drink. Honeysuckle has good antipyretic effect, energy anti-inflammatory, and what control inflammation oozes outAnd inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria are had to stronger antibacterial workWith, comprise staphylococcus, hemolytic streptococcus, diplococcus meningitidis, shigella dysenteriae, typhoid bacillus, ewcastle disease, Pseudomonas aeruginosa,Tubercle bacillus etc. In addition honeysuckle also has the effects such as cholagogic protects the liver, anti-oxidant, reducing blood lipid, central excitation.
The root bark of tree peony: bitter, pungent, cold nature, enters the heart, liver, kidney channel. " herbal classic ": " main fever and chills, apoplexy Chi Zong, convulsion, frightened epilepsy perverse trend,Except the hard hemostasis of disease stays house stomach, five viscera settling, treats carbuncle sore. " " Japan hanako materia medica ": ", except perverse trend, pleases look, the natural fibre line of meat blood vessels of being open to the custom, and apocenosis,Logical menstruation, disappears and flutters damage hemostasis, continuous muscles and bones, except wandering arthritis, the tire lower eyelid that falls, postpartum all cold and hot vim and vigour. ". Compendium of Material Medica: " enriching yinFall fire, separate spot poison, throat, diuresis stasis. Descendant specially controls fire mutually with yellow tiller, does not know that the merit of the root bark of tree peony more wins also. Red colored personProfit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it. " there is the effect of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in treating warm heat diseaseHeat invading xuefen, send out spot, tell nosebleed, hot Fu Yin of pyreticosis later stage divide heating, deficiency of Yin osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhoea, carbuncle sore tumefacting virus,Fall and flutter the card such as the pain of injury, rheumatic fever numbness. Kind purifying the blood, and invigorate blood circulation, thereby have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood,The absurd clearly and not row of blood-head. Therefore to diseases such as intense heat in the blood, liver kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine. Moutan bark is to anesthetized dogThe heart can increase CF, reduces cardiac output, reduces the effect of left chamber work done. Paeonol oral disposition typhoid fever, paratyphoid bacteriumThe mouse heating that seedling causes has refrigeration function, and reduces normal mouse body temperature.
Marine alga stone: cure mainly removing heat from the lung to relieve cough; Resolving phlegm and softening hard masses; Promoting diuresis for stranguria. Main lung heat is coughed and is breathed heavily; Phlegm is thick; Spit blood; Scrofula goiter and tumor;Gonorrhoea; Difficult urination.
Rhizoma zingiberis: pungent, hot. Return spleen, stomach, kidney, the heart, lung channel. Function cures mainly: rhizoma zingiberis warming spleen and stomach for dispelling cold, and Hui Yang promotes blood circulation, and eliminating dampness disappearsPhlegm. For coldness and pain in the epigastrium, vomiting is had loose bowels, the cold weak pulse of limb, and phlegm and retained fluid is breathed with cough.
Almond: hardship, tepor. " Mingyi Bielu ": " almond benevolence, adopt it May. Its two benevolence person kills a person, can malicious dog. Raw Jin ShanChuan Gu. " Shennong's Herbal: " main cough with dyspnea is thunderous, larynx numbness, lower gas, galactopoiesis metal-inflicted wound, the bitterly disappointed globefish that runs quickly. " " property of medicine opinion ": " controlAbdomen numbness is obstructed, sweating, main warm disease. Control completely pain of epigastric oppression, except trusted subordinate's unhappiness, treat lung qi cough, the shortness of breath. Enter lucid asparagus and decoct,Profit cardiopulmonary. Can make soup with junket, benefit profit information. Place i.e. moving cold air. " relieving cough and asthma, relax bowel. Collective Notes to the Canon of Materia medica: " obtain fieryGood. Dislike yellow over sixty years of age, the root of large-flowered skullcap, the root of kudzu vine. Wei Rang grass. " bitter temperature a surname of almond lung, relax bowel, be only suitable for the real examples such as ailment said due to cold or exposure, intestines be dry itSuffer from. All the moon loses, stagnated fire person, and unsuitable simple is for oral administration for a long time. As diseases such as pulmonary tuberculosis, bronchitis, chronic enteritis, dry cough without phlegmTaboo simple takes for a long time. Correct edible almond, can reach and promote the production of body fluid to quench thirst, moistening lung Dingchuan, laxation defaecation, the merit of minimizing enteron aisle cancerEffect. The method of the almond cooking is a lot, can be used for doing polytype food such as congee, cake, bread, other seasoning matter systems of can also arranging in pairs or groupsBecome delicious dish.
Blue gum: micro-pungent, micro-hardship, flat. Function cures mainly: dispelling wind is antipyretic, and inhibiting bacteria and diminishing inflammation is anticorrosion antipruritic. Be used for preventing popularityFlu, meningococal meningitis, control the infection of the upper respiratory tract, sphagitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, intestinesInflammation, dysentery, filariasis; Burn and scald is controlled in external application, cellulitis, and mastitis, furuncle, erysipelas, paddy-field dermatitis, skin eczema, the ringworm of the foot,Skin degerming.
Cape jasmine: bitter, cold, nontoxic; Enter the heart channel of Hang-Shaoyin, Liver Channel, lung channel, stomach warp, tri-jiao channel. Shennong's Herbal: " main five interior heresiesGas, pathogenic heat in the stomach gas, flushing wine blister Cha nose, the white red impetigo ulcer of leprosy. " " Mingyi Bielu ": " Great Cold, nontoxic. Cure mainly the red pain of order heat, chestThe large heat of heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas. " purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cooling blood and hemostasis. The pyreticosis heartTired, irascibility hot eyes, headache, jaundice with damp-heat pathogen, stranguria, bloody flux hematuria, aphthae, sore swollen toxin, sprains and swells and ache. This product bitter cold is clearFall, can rush down clearly three warmers fire-evil, purge the sthenic heart-fire and relieving restlessness, for controlling the key medicine that pyreticosis is vexed, dysphoria is not peaceful. There is sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels liver and gallbladder damp-heatEffect, availablely control liver and gallbladder damp-heat hot and suffocating jaundice, scanty drak urine person. The hypotensive activity position of cape jasmine, at maincenter, is mainlyStrengthen due to medulla oblongata parasympathetic maincenter tensity.
The dried rhizome of rehmannia: sweet, cold; The thoughts of returning home, liver, kidney channel. Shennong's Herbal: " taste is sweet, cold. Cure mainly folding and fall, muscle absolutely, in wound, by bloodNumbness, fills out marrow, longue meat. Make soup except fever and chills gather, remove numbness. Survivor is especially good. " heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new,Pain relieving, menstruation regulating, cool blood, hemostasis are invigorated blood circulation. The dried rhizome of rehmannia is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promotes the production of body fluid to quench thirst, and is usually used in treatmentThe diseases such as hectic fever due to yin consumptive disease heat, throat pain, blood-stained sputum. By by the dried rhizome of rehmannia taking fructus amomi, wine, dried orange peel as auxiliary material, repeatedly steam to shine to color and becomeBlack, quality softness is for cultivated land, and the Liuwei Dihuang Wan that has cultivated land to make is exactly famous kidney tonifying good medicine, clinical also conventionalIn the sick treatment such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.
Ivy glorybind: sweet, light, flat. Function cures mainly: root-like stock: strengthening the spleen and replenishing qi, diuresis, menstruation regulating, only band; For insufficiency of the spleen digestionBad, irregular menstruation, leukorrhea, milk rareness. Flower: pain relieving; Toothache is controlled in external application.
Fermented Soybean: pungent, sweet, micro-hardship, cold, property is flat; Return lung, stomach warp. " Mingyi Bielu ": " main cold headache fever and chills, miasma is dislikedPoison, irritated full vexed, consumptive disease is breathed heavily suction, and bipod pain is cold. Kill again all poison of six domestic animals tire. " " Japan hanako materia medica ": " and control intoxicant, legendary venomous insect gas,Malaria, hectic fever due to yin; And control dog and sting. " expelling pathogenic factors from muscles and skin delivers, and declares strongly fragrant relieving restlessness. Cure mainly diseases caused by external factors illness that has not attacked the vital organs of the human body, fever and chills headache, vexed, uncomfortable in chest, dysphoria is notSleep. Modern study, the composition such as Fermented Soybean is fatty, protein and enzyme, has faint perspiration, and has stomach invigorating, aid digestionEffect.
Reed rhizome: sweet, cold; Return lung channel, stomach warp. " property of medicine opinion ": " can separate large heat, appetizing. Control the sound of vomiting of choking more than. " " solar corona originallyGrass ": " disease unhappiness while controlling fever and chills, good pregnant popular feeling heat, and it is thirsty to rush down dysentery people. " clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis. Cure mainly: forPyreticosis polydipsia, gastropyretic vomiting, cough with lung heat, lung carbuncle pyemesis, heat are drenched puckery pain. Reed rhizome is for gastropyretic vomiting. Reed rhizome can heat-clearing andStomach preventing or arresting vomiting, does not grow again the greasy stomach that hinders, therefore the key medicine of vomitting the sound of vomiting for controlling stomach energy. The lighter is alone, and severe one is often joined caulis bambusae in taenian, ginger, polished riceDeng, with strengthen heat-clearing fall contrary, and the merit of middle preventing or arresting vomiting, side is as Thousand Golden Prescriptions Rhizomatis Phragmitis Potion. Can suppress frog neuromuscular sampleOxygen picked-up and the anaerobic glycolysis of the caused contractile response of electro photoluminescence and diaphragm in rats, have lax work in vitro cavy intestinal tubeWith.
Chinese holly: hardship, puckery, cool. " Bencao Tujing ": " ashing, face cream is coated with it, controls chap chilblain special effect, the double scar defect that goes out. " Chinese hollyControl cough with lung heat, abscess of throat, heat is drenched, and rushes down dysentery. This product bitter cold, is good at clearly purte the white and relieving heat toxin. Stop up on lung-fire, coughCough, pharyngalgia and anemopyretic cold; Or invade under hot poison, the puckery pain of dribbling urination, dysentery person, alone this product imitates. Chinese holly is controlledCold, fever, cough with lung heat, abscess of throat, the puckery pain of dribbling urination and dysentery, diarrhoea illness, can alone this product one or two, decoction; AlsoCan coordinate dandelion, Japanese Cayratia Herb, Commeline communis to be equal to use. This product has the effect of astringing to arrest bleeding. For traumatism and bleeding, can smash by alone fresh leafApply wound; Also can use cured leaf porphyrize, spread and apply at wound, additional wrapping. Chinese holly decoction is for oral administration can cause mild nausea and appetiteGo down, parenteral solution intramuscular injection part can cause pain, and quiet can cause pain and even phlebitis occurs, and Chinese holly is coated early burn woundFace also can have continue 5~10 minutes one cross property pain, above-mentioned bad reaction is all due to the volume tannin that contains of Chinese holly.
Rib leaf fragrant-flowered garlic: pungent, bitter, temperature. Function cures mainly: regulates the flow of vital energy, and wide chest. Cure mainly pectoralgia, uncomfortable in chest, cough, dysentery.
Beggar-ticks: for the conventional herbal medicine of folks of china, have effect clearing heat and detoxicating, blood-stasis-dissipating blood-circulation-promoting, cure mainly the infection of the upper respiratory tract,Abscess of throat, acute appendicitis, acute icteric hepatitis, gastroenteritis, Fengshi Guanjie pain, malaria, sore furuncle is controlled in external application, poisonous snake stingsWound, treating swelling and pain by traumatic injury. Herb is containing alkaloid, tannin, saponin, glycosides displayed. Cauline leaf is containing volatile oil, tannin, amaroid, choline etc. ReallyReal oil-containing 27.3%. Water decoction or alcohol preserved material that equivalent beggar-ticks and clerodendron trichotomum are mixed, give Oral Administration in Rats, dosageBe 10 grams (crude drugs)/kilogram sky, totally 5 days, PARA FORMALDEHYDE PRILLS(91,95) and egg white " arthritis " all had obvious antiinflammation.
Kalimeris: pungent, flat. Function is clearing heat and detoxicating, cooling blood and hemostasis, diuresis. For nosebleed, bleeding gums, spitting of blood, subcutaneous go outBlood, and the disease such as abscess of throat.
Pears skin: sweet; Puckery; Cool; Nontoxic. Return lung; The heart; Kidney; Large intestine channel. Function cures mainly: heart clearing, lung moistening; Fall fire and promote the production of body fluid, separate sorePoison. Main hot summer weather polydipsia; Xeropulmonary cough; Spit blood; Dysentery; ; Mange; Carbuncle on the back; Furunculosis.
Pen shell shell: taste is salty; Puckery; Cool in nature. Function cures mainly: clearing heat and detoxicating; Calmness relieves dizziness, high fever, infantile convulsions, epilepsy, etc. Main wet polymer; Hypertension
Snakegourd Fruit: nature and flavor sweetness and bitterness, cold. Enter lung, stomach, large intestine channel. Compendium of Material Medica is said: " moistening lung is dry, falls fire. Control cough, wash phlegmKnot, throat, subduing inflammation sore. " " book on Chinese herbal medicine is just read " record: " and Snakegourd Fruit, nature and flavor are identical with pollen, only moisten the merits and demerits of falling it. Therefore allStagnation of heat in upper-JIAO, the cards such as dirty greasy phlegm-fire cough, all can use it. The fiery person of genus of all lung carbuncle, acute appendicitis, acute mastitis, particularly suitable. " functionCure mainly: moistening lung, reduce phlegm, dissipating bind, ease constipation. Control phlegm-heat cough, the obstruction of qi in the chest, accumulation of pathogens in chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, at the beginning of carbuncle is swollenRise.
Dried mushroom: sweet; Pungent; Property is put down. Return lung; Spleen; Stomach warp. Function cures mainly: invigorating the spleen qi-restoratives; The cough-relieving of a surname's lung; Promoting eruption. Main dizzinessWeak; God is tired indigestion and loss of appetite; Indigestion; Cough and asthma; Measles is wanted; Have the fidgets.
Tussilago: pungent, micro-hardship, temperature. Return lung channel. Function cures mainly: moistening lung to lower qi is relieving cough and reducing sputum. Cough for new chronic cough, breath with coughPhlegm is many, the labor hemoptysis of coughing.
Rose: warm in nature, sweet and slightly bitter taste, returns liver the spleen channel. Supplementary Amplifications of the Compendium of Materia Medica: " and blood, promoting circulation of blood, regulates the flow of vital energy. Control wandering arthritis. "" book on Chinese herbal medicine is new again ": " the strongly fragrant gas of the liver and gall of relaxing, fire falls in invigorating the spleen. Control crymodynia in abdomen, gastral cavilty is long-pending cold, holds concurrently and can break blood. " sharp gas, promoting circulation of blood, controlWandering arthritis, loose tired pain relieving. Rose and complete stool have convergence, can be used for woman in menstrual period too much, leukorrhea with reddish discharge and enteritis, underDysentery, the red half of intestines are hemorrhage etc. The loose stasis of blood of Xie Yu and blood of regulating the flow of vital energy. Cure mainly stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, new wandering arthritis for a long time, the spitting of blood of spitting blood, irregular menstruation,Leukorrhea with reddish discharge, dysentery, acute mastitis, pyogenic infections. In rose, contain 300 various chemical components, as fragrant alcohol, aldehyde, aliphatic acid, phenol andContaining oil and the fat of essence, often eat in rose goods with the soft liver stomach of waking up, to have a respite and invigorate blood circulation, beautifying face and moistering lotion, makes us refreshing refreshing.
Radish seed: the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm. Cure mainly stagnation of QI due to dyspepsia, abdominal fullness and distention, belch, heavy after diarrhea, cough phlegmMany, syndrome characterized by dyspnea fullness sensation in chest. Stop up and breath with cough for retention of food and drink, abdominal distention, constipation, the stagnant dysentery, phlegm of rushing down. Enter spleen, stomach, lung channel, energyThe de-swelling that helps digestion, effect is remarkable, has the title of " rush wall fall wall ". Clinical habit is used for the treatment of, and real (food, wet, stagnant) demonstrate,proved.
Block close: sweet acid is micro-salty, temperature. Function cures mainly: strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood. Control gynecological ailments, qi and blood twoLose, incoordination between the spleen and the stomach, indigestion, irregular menstruation, waist abdomen pain.
Han dish: sweet, light, cool. Function cures mainly: clearing heat and detoxicating, and antibechic, diuresis. For cold, fever, abscess of throat, lung heatCough, chronic bronchitis, acute rheumatic arthritis, hepatitis, difficult urination; Dermatitis rhus is controlled in external application, snake bite, and furunculosis carbuncle is swollen.
Perilla frutescens: pungent; Temperature; Nontoxic. Return lung; Spleen; Large intestine channel. Function cures mainly: lower gas; Dissolving phlegm; Moistening lung; Wide intestines. Main coughingContrary; Asthma due to excessive phlegm; Stagnation of the circulation of vital energy constipation.
Balloonflower root: bitter, pungent, property is flat. Return lung channel. There is a surname's lung, eliminate the phlegm, relieve sore throat, apocenosis, sharp the five internal organs, fill blood, mend fiveLabor, the effect of fostering the spirit of nobility. Cure mainly coughing with a lot of sputum, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery stomachache, aphthae, hot eyesSwell and ache, uroschesis. For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia, hoarsen, lung carbuncle pyemesis, sore purulence does not become to burst. " herbal classic " said:" main chest and hypochondrium is as lancination, and abdomen is full, and borborygmus are faint, the gas of throbbing with fear in terror ". " Japan hanako materia medica " said: " lower all gas, only choleraic myospasm,Trusted subordinate's distending pain, mends the exhaustion or lesion of the five internal organs, fosters the spirit of nobility, and evil removing is warded off temperature, qi-restoratives dissolving phlegm, and broken abdominal mass, the apocenosis of nourishing blood, leaks and larynx numbness in mending ". Modern pharmacologyResearch shows, balloonflower root has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action;Calmness, analgesia and refrigeration function.
Fructus Hordei Germinatus: nature and flavor are sweet is flat. Return spleen, stomach warp, Liver Channel. " Japan hanako materia medica ": " in temperature, lower gas, appetizing, only cholera, removesTired, dissolving phlegm, broken crux, can expedite the emergence of tire. " " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " and in wide, lower gas, preventing or arresting vomiting is told, the place food that disappears, only acid regurgitation acid regurgitation, onlyRush down, the wide diaphragm of the stomach that disappears, and control married woman's milk breast and do not receive, milk is more than. " thering is promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back effect of newborn dissipate-swelling.Cure mainly dyspepsia and do not disappear, abdominal distention, insufficiency of the spleen food is few, and newborn sweat smoulders, swollen breasts, women's ablactation. Fructus Hordei Germinatus can be used for stagnation of QI due to depression of the liver,The chest side of body is swollen vexed, and liver spleen is not each, and belch is eaten less and waited card, often and the compatibility such as Buddha's hand, and to increase the effect of its easypro liver and stomach. It is weakness of the spleen and the stomach,Transporting is unable, and causes the dyspepsia person that do not disappear, and can be equal to use with Radix Codonopsis, the bighead atractylodes rhizome, dried orange peel, to increase the power of reinforcing spleen to promote digestion. Lactation womanFemale should not use; Eat for a long time the kidney that disappears, can not eat more; Cardamom, contracting sand, pawpaw, Chinese herbaceous peony, the fruit of Chinese magnoliavine, dark plum make for it; Without stagnant, spleenStomach void person should not use; Woman has the pregnant person of tire to take more; All convulsive seizure due to phlegm-fire asthma and pregnant woman, can't use.
Hericium erinaceus: sweet, flat. Function cures mainly: sharp the five internal organs are aid digestion. Cure mainly indigestion, neurasthenia, in poor health.
Below adopt embodiment to describe embodiments of the present invention in detail, whereby to how application technology means of the present inventionSolve technical problem, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive
The embodiment of the present invention provides a kind of pharmaceutical composition that is used for the treatment of porcine contagious pleuropneumonia, and its formulation isGranula, in pharmaceutical composition, the parts by weight of each raw medicinal material are: golden cypress 28 weight portions, the root of large-flowered skullcap 10 weight portions, cordate houttuynia 18 weightsAmount part, honeysuckle 25 weight portions, the root bark of tree peony 14 weight portions, marine alga stone 15 weight portions, rhizoma zingiberis 28 weight portions, almond 20 weight portions, indigo plantEucalyptus 17 weight portions, cape jasmine 12 weight portions, the dried rhizome of rehmannia 14 weight portions, ivy glorybind 18 weight portions, Fermented Soybean 20 weight portions, reed rhizome 27 weightPart, Chinese holly 15 weight portions, rib leaf fragrant-flowered garlic 10 weight portions, beggar-ticks 17 weight portions, kalimeris 13 weight portions, pears skin 15 weight portions, riverYao shell 15 weight portions, Snakegourd Fruit 17 weight portions, dried mushroom 14 weight portions, tussilago 20 weight portions, rose 15 weight portions, radish seed 12Weight portion, block close 20 weight portion, Han dish 15 weight portions, Perilla frutescens 15 weight portions, balloonflower root 18 weight portions, Fructus Hordei Germinatus 15 weight portions and monkeyMushroom 12 weight portions.
Its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, what to add with respect to the determining alcohol of 7 times, mixture be 90%Ethanol, is heated to boiling reflux 4 hours, filters, and adopts the speed slowly diacolation of percolation with 1ml per minute, collects percolate,The lotion that while being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is 1.06, spraying is dry, spray dryer170 DEG C of EATs, 80 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;
Second step: add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and the paste of 0.1 times in the dried cream powder obtainingEssence, granulation, in 45 DEG C dry, obtain Chinese medicine additive.
Embodiment 2 feeds
The embodiment of the present invention provides a kind of feed that is used for the treatment of porcine contagious pleuropneumonia, wherein each raw medicinal materialParts by weight are: corn 77 weight portions, glutinous rice 65 weight portions, dregs of beans 26 weight portions, peanut meal 21 weight portions, lotus root starch 32 weightPart, fish meal 19 weight portions, seawood meal 23 weight portions, honey 6 weight portions, egg 10 weight portions that boil, vegetable oil 6 weightPart, salt 3 weight portions, vitamin premix 0.3 weight portion and Chinese medicine additive 4 weight portions;
Chinese medicine additive is made up of the raw medicinal material of following parts by weight: golden cypress 25 weight portions, the root of large-flowered skullcap 13 weight portions, fish raw meatGrass 16 weight portions, honeysuckle 23 weight portions, the root bark of tree peony 16 weight portions, marine alga stone 13 weight portions, rhizoma zingiberis 25 weight portions, almond 23 weightPart, blue gum 16 weight portions, cape jasmine 13 weight portions, the dried rhizome of rehmannia 15 weight portions, ivy glorybind 16 weight portions, Fermented Soybean 18 weight portions, reed rhizome26 weight portions, Chinese holly 17 weight portions, rib leaf fragrant-flowered garlic 13 weight portions, beggar-ticks 15 weight portions, kalimeris 12 weight portions, pears skin 16 weightPart, pen shell shell 17 weight portions, Snakegourd Fruit 14 weight portions, dried mushroom 13 weight portions, tussilago 17 weight portions, rose 17 weight portions, LayFu 13 weight portions, block close 18 weight portion, Han dish 16 weight portions, Perilla frutescens 17 weight portions, balloonflower root 16 weight portions, Fructus Hordei Germinatus 13 weightPart and Hericium erinaceus 14 weight portions.
The preparation method of Chinese medicine additive comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, what to add with respect to the determining alcohol of 7 times, mixture be 90%Ethanol, is heated to boiling reflux 4 hours, filters, and adopts the speed slowly diacolation of percolation with 1ml per minute, collects percolate,The lotion that while being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is 1.06, spraying is dry, spray dryer170 DEG C of EATs, 80 DEG C of leaving air temps, be ground into subsequently powder, make dried cream powder;
Second step: add with respect to the cane sugar powder of 0.3 times of dried cream powder quality and the paste of 0.1 times in the dried cream powder obtainingEssence, granulation, in 45 DEG C dry, obtain Chinese medicine additive.
The preparation method of feed comprises the following steps:
(1) pulverising step: take all raw materials according to parts by weight, drop into pulverizer and pulverize, grinding particle size is1.5mm;
(2) blend step: raw material and surplus stock after step (1) is pulverized drop into mixer, mix, when mixingBetween be 5 minutes;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 80 DEG C.
Toxicity test
Acute toxicity test: 60 of application NIH mouse, SPF level, male and female half and half, body weight 17~24g, carries out acute toxicityTest. Mouse is divided into two groups at random, and 20 every group, i.e. control group and administration group, fasting 12 hours before experiment; By reality of the present inventionExecute Chinese medicine additive prepared by example 1 and be dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), control group gives equivalent physiological saline, and administration in a day 2 times, between administration6 hours intervals, Continuous Observation 14 days after administration, and record mouse toxic reaction and death toll. Experimental result shows: withControl group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, mouse overall health of patients, diet, drinking-water, bodyHeavily increase all normal. Therefore tablet acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the Chinese medicine additive of the embodiment of the present invention 1 to mouse by 6.43,15.72 and 36.41g raw16 weeks (1.0ml/100g body weight, every day 2 times) of medicine/kg continuous use and drug withdrawal are after 4 weeks, and result shows: Chinese medicine preparation of the present inventionThe indexs such as hair to mouse, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat are all without obviouslyImpact, internal organs naked eyes do not find that difference changes and histological examination result shows, and medication 16 weeks and drug withdrawal are after 4 weeks, and mouse is eachInternal organs are all without obviously changing. Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mouse long-term prescription, after drug withdrawal, also do not have difference anti-Should, application safety.
Contrast test
In October, 2012, there are 500 growing and fattening pigs nearly on large-scale pig farm, Shandong, wherein 300 about bull 50kgGrowing and fattening pigs, part pig occurs that expiratory dyspnea anorexia, high heat are delaied and the phenomenon such as do not move back, dead pig is cutd open inspection and is shown as lung and beAubergine, is full of foam-like, courageous and upright mucus and mucous membrane exudate in tracheae, bronchus, pneumonia district occurs that fiber disposition thing investsSurface, and have yellow diffusate, larynx is full of bloody fluid, the remarkable enlargement of hilar lymph node, hepatosplenomegaly, subduing. From propping upTracheae is separated to pathogen, and microscopy Gram's staining smear is shown in most gram-negative coccobacilluses. Be diagnosed as pig transmissible chestMembrane lung inflammation. Immediately to the sick pig isolation processing of 500 bulls.
Choose 240 of ill pigs, be divided at random three experimental group, 80 every group, be respectively embodiment group 1, embodiment group 2And control group, use respectively diverse ways to treat: embodiment group 1 is used the granule of the embodiment of the present invention 1 to controlTreat, granule is sneaked in conventional feed according to the ratio of 5:100, feed according to the normal mode of feeding, treat continuously 3-7 days;Embodiment group 2 is used the feed of the embodiment of the present invention 2 to treat, and feeds according to the normal mode of feeding, and uses continuously 3-7 days;Control group uses conventional medicament to treat, intramuscular injection ceftiofur sodium (5mg/1kg)+Florfenicol (20mg/1kg), and 1 time/d,Treatment 4-7 days continuously. Separately, choose 80 of healthy growing and fattening pigs as blank group.
The standard of curative effect evaluation: clinical cure: appetite, body temperature, breathing recover normal, and the state of mind is good; Take a turn for the better: under body temperatureFall but do not recover normal, feed intake rises but does not return to normal level, and the state of mind is general, and occasionally has cough; Invalid:Appetite extreme difference, body temperature does not fall, and before cough is equal to treatment with breathing state, compares and is not improved, and spirit is depressed. Wherein, efficientFor cure rate and improvement rate sum.
The each experimental group treatment results of table 1 table of comparisons
In the each experimental group of table 2, treat ill pig clinical cure and the table of comparisons of time in 3-7 days
In the each experimental group of table 3, treat the average weight table of comparisons of 7 days ill pigs in front and back
Can find out from above-mentioned table 1-3, use the feed of the present invention ill pig treatment pig transmissible pleurisy of feeding to haveRapid-action, determined curative effect, safe, the advantage that has no side effect; And use feed of the present invention not only can treat pigInfectious pleurisy, and can also meet the nutritional need of ill pig, ensure the production performance of growing and fattening pigs.
The Distributions in Liaocheng of Shandong Province self-employed worker that raises pigs raises 12 of pigs, and body weight all, in 45kg left and right, is found 2 pigs in September, 2012There is expiratory dyspnea anorexia, hyperthermia to 41 DEG C, heart rate increases, and spirit is depressed, engenders expiratory dyspnea, cough etc.Symptom, other pigs also engender above-mentioned symptom; Tentatively be diagnosed as porcine contagious pleuropneumonia, use the embodiment of the present invention 1Medicine treat, granule is sneaked in feed according to the ratio of 5:100, feed according to the normal mode of feeding, control continuouslyTreat after 3 days, pig symptom is clearly better, continual cure 3 days, all recovery from illness.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all in spirit of the present invention andWithin principle, any amendment of doing, be equal to replacement, improvement etc., within protection scope of the present invention all should be included in.

Claims (5)

1. a pig feed, is characterized in that, described feed is made up of the raw material of following parts by weight: corn 50-80 weight portion,Glutinous rice 40-70 weight portion, dregs of beans 20-30 weight portion, peanut meal 15-25 weight portion, lotus root starch 20-44 weight portion, fish meal 10-26 weighAmount part, seawood meal 15-27 weight portion, honey 5-8 weight portion, the egg 8-12 weight portion boiling, vegetable oil 5-7 weight portion,Salt 1-5 weight portion, vitamin premix 0.1-0.5 weight portion and Chinese medicine additive 1-7 weight portion;
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: golden cypress 20-30 weight portion, root of large-flowered skullcap 10-15 weightPart, cordate houttuynia 10-20 weight portion, honeysuckle 15-30 weight portion, root bark of tree peony 10-20 weight portion, marine alga stone 10-15 weight portion, rhizoma zingiberis20-30 weight portion, almond 15-30 weight portion, blue gum 10-20 weight portion, cape jasmine 10-15 weight portion, dried rhizome of rehmannia 10-20 weight portion,Ivy glorybind 10-20 weight portion, Fermented Soybean 10-25 weight portion, reed rhizome 20-30 weight portion, Chinese holly 10-25 weight portion, rib leaf fragrant-flowered garlic10-15 weight portion, beggar-ticks 10-20 weight portion, kalimeris 10-15 weight portion, pears skin 10-20 weight portion, pen shell shell 10-25 weightPart, Snakegourd Fruit 10-20 weight portion, dried mushroom 10-15 weight portion, tussilago 10-25 weight portion, rose 10-25 weight portion, radish seed10-15 weight portion, block close 10-25 weight portion, Han dish 10-20 weight portion, Perilla frutescens 10-25 weight portion, balloonflower root 10-20 weightPart, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 10-15 weight portion.
2. pig feed according to claim 1, is characterized in that, in described feed, the parts by weight of each raw medicinal material are:Corn 77 weight portions, glutinous rice 65 weight portions, dregs of beans 26 weight portions, peanut meal 21 weight portions, lotus root starch 32 weight portions, fish meal 19 weightPart, seawood meal 23 weight portions, honey 6 weight portions, egg 10 weight portions that boil, vegetable oil 6 weight portions, salt 3 weight portions,Vitamin premix 0.3 weight portion and Chinese medicine additive 4 weight portions.
3. pig feed according to claim 1, is characterized in that, the weight portion of each raw medicinal material in described Chinese medicine additiveNumber is: golden cypress 22-28 weight portion, root of large-flowered skullcap 10-15 weight portion, cordate houttuynia 15-18 weight portion, honeysuckle 20-25 weight portion, the root bark of tree peony14-18 weight portion, marine alga stone 10-15 weight portion, rhizoma zingiberis 23-28 weight portion, almond 20-25 weight portion, blue gum 15-17 weightPart, cape jasmine 12-14 weight portion, dried rhizome of rehmannia 14-16 weight portion, ivy glorybind 15-18 weight portion, Fermented Soybean 15-20 weight portion, reed rhizome25-27 weight portion, Chinese holly 15-20 weight portion, rib leaf fragrant-flowered garlic 10-15 weight portion, beggar-ticks 13-17 weight portion, kalimeris 11-13 weighAmount part, pears skin 15-17 weight portion, pen shell shell 15-20 weight portion, Snakegourd Fruit 12-17 weight portion, dried mushroom 11-14 weight portion, tussilago15-20 weight portion, rose 15-20 weight portion, radish seed 12-14 weight portion, block close 15-20 weight portion, Han dish 15-17 weightPart, Perilla frutescens 15-20 weight portion, balloonflower root 15-18 weight portion, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 12-15 weight portion.
4. pig feed according to claim 1, is characterized in that, the weight portion of each raw medicinal material in described Chinese medicine additiveNumber is: golden cypress 25 weight portions, the root of large-flowered skullcap 13 weight portions, cordate houttuynia 16 weight portions, honeysuckle 23 weight portions, the root bark of tree peony 16 weight portions, seaAlgae stone 13 weight portions, rhizoma zingiberis 25 weight portions, almond 23 weight portions, blue gum 16 weight portions, cape jasmine 13 weight portions, the dried rhizome of rehmannia 15 weightPart, ivy glorybind 16 weight portions, Fermented Soybean 18 weight portions, reed rhizome 26 weight portions, Chinese holly 17 weight portions, rib leaf fragrant-flowered garlic 13 weight portions,Beggar-ticks 15 weight portions, kalimeris 12 weight portions, pears skin 16 weight portions, pen shell shell 17 weight portions, Snakegourd Fruit 14 weight portions, dried mushroom 13 weightsAmount part, tussilago 17 weight portions, rose 17 weight portions, radish seed 13 weight portions, block close 18 weight portion, Han dish 16 weight portions,Perilla frutescens 17 weight portions, balloonflower root 16 weight portions, Fructus Hordei Germinatus 13 weight portions and Hericium erinaceus 14 weight portions.
5. according to the pig feed described in claim 1-4 any one, it is characterized in that preparation method's bag of described Chinese medicine additiveDraw together following steps:
The first step: described raw medicinal material is mixed in described ratio, add with respect to the determining alcohol of 4~8 times, mixture be 85%~95% ethanol, is heated to boiling reflux 3~5 hours, filters, and adopts the speed slowly diacolation of percolation with 1~2ml per minute,Collect percolate, while being evaporated to 50~60 DEG C subsequently under vacuum 0.06~0.09Mpa relative density be 1.04~1.10 lotion, spraying is dry, and 160~175 DEG C of the EATs of spray dryer, 80~85 DEG C of leaving air temps are pulverized subsequentlyPowdered, makes dried cream powder;
Second step: add in the dried cream powder obtaining with respect to the cane sugar powder of 0.2~0.4 times of dried cream powder quality and 0.1~0.2 timesDextrin, granulation, in 40~50 DEG C dry, obtain Chinese medicine additive.
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