CN105012917A - Medicine for treating reflux esophagitis - Google Patents

Abstract

The invention provides medicine for treating reflux esophagitis. The medicine comprises the raw materials of fructus gardeniae, radix ophiopogonis, radix bupleuri, Chinese dates, costus roots, angelica dahurica, dried ginger, inula flowers, golden cypresses, red sage roots, radish seeds, fritillary bulbs, coix seeds, aralia fargesii, sweet clovers, four-leaf clovers, akebia fruits, pawpaws, gorgon euryale seeds, willow herbs and negundo chastetree fruits. The medicine has a definite clinical treatment effect, promotes repairing of esophageal mucosae, and is safe to take orally for a long time, small in side effect, low in relapse rate and capable of remarkably improving living quality after curing, the long-term treatment effect is satisfactory, and the medicine is worthy of being widely and clinically popularized.

Description

Be used for the treatment of the medicine of reflux esophagitis

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of medicine being used for the treatment of reflux esophagitis.

Background technology

Reflux esophagitis refers to that gastric content or Duodenal reflux enter esophagus, and contained acidic materials destroy who film of esophagus and occur chronic inflammatory disease, can make esophagus generation ulcer, narrow, canceration etc.Reflux esophagitis is the one of gastroesophageal reflux disease, is the common disease of Digestive System Department.With retrosternal pain, heartburn acid regurgitation, vomiting poor appetite, or there are odynophagia, dysphagia, foreign body in pharynx sense etc. to be main clinical characteristics, have a strong impact on diet, sleep and work, and can multiple complications be occurred.If reflux long-term existence, form cicatrix and narrow the most at last.

Reflux esophagitis belongs to the category such as " acid regurgitation ", " thoracic obstruction ", " noisy ", " acid regurgitation " in motherland's medical science.Although its sick position is prolonged and appetite and throat at esophagus, be that gastric qi led in fact, except relevant to liver, spleen, also relevant with lung.Because excessive use is pungent, the thing that stimulates such as tobacco and wine and cause spleen injury, transformation failure of spleen, liver receives catharsis, and hot and suffocating by interior and give birth to, mental disorder obstruct, the reflux thing that QI rising in reverse order is not fallen and caused enters people's esophagus and causes reflux esophagitis.Gastric qi led, dirty closely related with liver, spleen two, stomach receiving food and drink, logically to fall; Liver master dredges pond, harmonizing the functional activities of vital QI; The spleen has the function to transport and transform nutrients, main the lucid yang sending up.Three dirty coordinations, then mechanism of qi is smooth and easy.If eating and drinking without temperance, food and drink is immoderate, and eat thing such as pungent perfume (or spice) scorching grade, then injure one's stomach stagnant spleen.Disorder of emotion, depressed rage impairing the liver, then liver mistake bar reaches, and perverse and unreasonable manner violates stomach.Prolonged illness consumption damaging the spleen and stomach gas, insufficiency of the spleenly can not bear water paddy, and taste dereliction of duty etc. all can cause incoordination between the liver and stomach.Dysfunction of the spleen in transportation, stomach-QI being unable to descend normally, functional activity of QI being not smooth, foul smell heat-transformation upper punch, strongly fragrantly hinders caused by the septum pectorale.Therefore, taste are not enough, endogenous damp formation, strongly fragrant heat-transformation of a specified duration, and expectorant hot glue hinders, functional activity of QI being not smooth, so that adverse rising of stomach-QI is the basic pathogenesis of primary disease, and expectorant heat is this pathogenetic key factor, therefore with depressed liver-energy dispersing and QI regulating, regulating the stomach and sending down the abnormal ascending QI in treatment, heat clearing awayization is turbid is principle.The present invention is exactly theoretical according to above-mentioned Chinese traditional treatment, a kind of medicine being used for the treatment of reflux esophagitis proposed, its clinical efficacy is definite, promote mucous membrane of esophagus reparation, and Long-term Oral use safety, side effect is little, relapse rate is low, can significantly improve more quality of life, late result is satisfied, and clinic is extensively promoted.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of reflux esophagitis, its clinical efficacy is definite, promote mucous membrane of esophagus reparation, and Long-term Oral use safety, side effect is little, and relapse rate is low, can significantly improve more quality of life, late result is satisfied, and clinic is extensively promoted.

For solving the problems of the technologies described above, the invention provides a kind of medicine being used for the treatment of reflux esophagitis, its crude drug comprises Fructus Gardeniae grandiflorae, Radix Ophiopogonis, Radix Bupleuri, Fructus Jujubae, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Flos Inulae, Cortex Phellodendri, Radix Salviae Miltiorrhizae, Semen Raphani, Bulbus Fritillariae Thunbergii, Semen Coicis, careless Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Akebiae, Fructus Chaenomelis, Semen Euryales, LIUYECAI and gold line.

Wherein, in described medicine the weight of each crude drug be respectively Fructus Gardeniae grandiflorae 20g ~ 30g, Radix Ophiopogonis 15g ~ 25g, Radix Bupleuri 10g ~ 20g, Fructus Jujubae 20g ~ 30g, Radix Aucklandiae 10g ~ 20g, Radix Angelicae Dahuricae 25g ~ 35g, Rhizoma Zingiberis 10g ~ 20g, Flos Inulae 10g ~ 20g, Cortex Phellodendri 35g ~ 45g, Radix Salviae Miltiorrhizae 20g ~ 30g, Semen Raphani 10g ~ 20g, Bulbus Fritillariae Thunbergii 15g ~ 25g, Semen Coicis 10g ~ 20g, careless Radix Angelicae Pubescentis 10g ~ 20g, melilotus 15g ~ 25g, Herba Galii Bungei 10g ~ 20g, Fructus Akebiae 10g ~ 20g, Fructus Chaenomelis 5g ~ 15g, Semen Euryales 10g ~ 20g, LIUYECAI 10g ~ 20g and gold line 5g ~ 15g.

Wherein, in described medicine the weight of each crude drug be respectively Fructus Gardeniae grandiflorae 23g ~ 27g, Radix Ophiopogonis 18g ~ 22g, Radix Bupleuri 13g ~ 17g, Fructus Jujubae 23g ~ 27g, Radix Aucklandiae 13g ~ 17g, Radix Angelicae Dahuricae 28g ~ 32g, Rhizoma Zingiberis 13g ~ 17g, Flos Inulae 13g ~ 17g, Cortex Phellodendri 38g ~ 42g, Radix Salviae Miltiorrhizae 23g ~ 27g, Semen Raphani 13g ~ 17g, Bulbus Fritillariae Thunbergii 18g ~ 22g, Semen Coicis 13g ~ 17g, careless Radix Angelicae Pubescentis 13g ~ 17g, melilotus 18g ~ 22g, Herba Galii Bungei 13g ~ 17g, Fructus Akebiae 13g ~ 17g, Fructus Chaenomelis 8g ~ 12g, Semen Euryales 13g ~ 17g, LIUYECAI 13g ~ 17g and gold line 8g ~ 12g.

Present invention also offers the preparation method of said medicine, it comprises:

The first step, water intaking Cape jasmine, Radix Bupleuri, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Cortex Phellodendri, Semen Raphani, Semen Coicis, careless Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Chaenomelis, LIUYECAI and gold line, adopt concentration to be that 0.1% hydrochloric acid solution extracts, extracting solution purification, reclaim under reduced pressure, obtains dry first powder;

Second step, goes remaining crude drug component, and adopt water extraction, extracting solution purification, reclaim under reduced pressure, obtains dry second powder;

3rd step, by the first powder and the mixing of the second powder, add various adjunct ingredient as required, conveniently preparation method is prepared into various conventional formulation.

Wherein, the described first step is specially further, water intaking Cape jasmine, Radix Bupleuri, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Cortex Phellodendri, Semen Raphani, Semen Coicis, grass Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Chaenomelis, LIUYECAI and gold line, clean respectively, pulverize, mix, obtain mixture, adding relative to mixture quality 10 ~ 20 times amount concentration is the hydrochloric acid of 0.1%, reflux, extract, 1 ~ 3 hour, filters, it is 0.1% hydrochloric acid that filtering residue adds relative to mixture quality 10 ~ 20 times amount concentration again, reflux, extract, 1 ~ 3 hour, filters, merging filtrate, being evaporated to 60 DEG C of relative densities is 1.05 ~ 1.10, obtain sour extracted extract, being cooled to room temperature, is that 10% ~ 30% sodium hydroxide is adjusted to neutrality by concentration, add ethanol again and reach 70% to alcohol content, leave standstill 6 ~ 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.05 ~ 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, uses water successively, determining alcohol is 5% ~ 30% ethanol elution, discards eluent, then is 45% ~ 55% ethanol elution with determining alcohol, and collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the first powder.

Wherein, crude drug component under remainder, clean respectively, pulverize, mix, obtain mixture, add relative to mixture quality 10 ~ 20 times of water gagings, reflux, extract, 1 ~ 3 hour, filter, filtering residue adds relative to mixture quality 10 ~ 20 times of water gagings again, reflux, extract, 1 ~ 3 hour, filter, merging filtrate, at being evaporated to 60 DEG C, relative density is 1.05 ~ 1.10, obtain the water extracted immersing paste, be cooled to room temperature, add ethanol and reach 70% to alcohol content, leave standstill 6 ~ 12 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.05 ~ 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, wash with water, discard eluent, be 10% ~ 20% ethanol elution with determining alcohol again, collect eluent, decompression recycling ethanol is to dry, be ground into powder, obtain the second powder.

Wherein, when prepared dosage form is granule; 3rd step is specially mass percent 20% ~ 30% cane sugar powder added by the powder of mixing relative to mixed-powder quality; be 75% ~ 85% ethanol soft material with determining alcohol, granulate with oscillating granulator, dry at 60 DEG C; granulate; obtain medicinal granule, splitting splendid attire, every bag of 10g.

Wherein, when prepared dosage form is capsule, the 3rd step is specially gets 300g mixed-powder, adds 40g polyvidone, is distributed into capsule, each capsule 0.5g.

Beneficial effect of the present invention:

The medicine being used for the treatment of reflux esophagitis provided by the invention, its clinical efficacy is definite, promotes mucous membrane of esophagus reparation, and Long-term Oral use safety, side effect is little, and relapse rate is low, can significantly improve more quality of life, late result is satisfied, and clinic is extensively promoted.

Detailed description of the invention

The invention provides a kind of medicine being used for the treatment of reflux esophagitis, its crude drug comprises Fructus Gardeniae grandiflorae, Radix Ophiopogonis, Radix Bupleuri, Fructus Jujubae, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Flos Inulae, Cortex Phellodendri, Radix Salviae Miltiorrhizae, Semen Raphani, Bulbus Fritillariae Thunbergii, Semen Coicis, careless Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Akebiae, Fructus Chaenomelis, Semen Euryales, LIUYECAI and gold line.

Further preferably, described medicine is only prepared from by above-mentioned raw materials medicine.

In described medicine, the weight of each crude drug is respectively Fructus Gardeniae grandiflorae 20g ~ 30g, Radix Ophiopogonis 15g ~ 25g, Radix Bupleuri 10g ~ 20g, Fructus Jujubae 20g ~ 30g, Radix Aucklandiae 10g ~ 20g, Radix Angelicae Dahuricae 25g ~ 35g, Rhizoma Zingiberis 10g ~ 20g, Flos Inulae 10g ~ 20g, Cortex Phellodendri 35g ~ 45g, Radix Salviae Miltiorrhizae 20g ~ 30g, Semen Raphani 10g ~ 20g, Bulbus Fritillariae Thunbergii 15g ~ 25g, Semen Coicis 10g ~ 20g, grass Radix Angelicae Pubescentis 10g ~ 20g, melilotus 15g ~ 25g, Herba Galii Bungei 10g ~ 20g, Fructus Akebiae 10g ~ 20g, Fructus Chaenomelis 5g ~ 15g, Semen Euryales 10g ~ 20g, LIUYECAI 10g ~ 20g and gold line 5g ~ 15g.

Further preferably, in described medicine, the weight of each crude drug is respectively Fructus Gardeniae grandiflorae 23g ~ 27g, Radix Ophiopogonis 18g ~ 22g, Radix Bupleuri 13g ~ 17g, Fructus Jujubae 23g ~ 27g, Radix Aucklandiae 13g ~ 17g, Radix Angelicae Dahuricae 28g ~ 32g, Rhizoma Zingiberis 13g ~ 17g, Flos Inulae 13g ~ 17g, Cortex Phellodendri 38g ~ 42g, Radix Salviae Miltiorrhizae 23g ~ 27g, Semen Raphani 13g ~ 17g, Bulbus Fritillariae Thunbergii 18g ~ 22g, Semen Coicis 13g ~ 17g, grass Radix Angelicae Pubescentis 13g ~ 17g, melilotus 18g ~ 22g, Herba Galii Bungei 13g ~ 17g, Fructus Akebiae 13g ~ 17g, Fructus Chaenomelis 8g ~ 12g, Semen Euryales 13g ~ 17g, LIUYECAI 13g ~ 17g and gold line 8g ~ 12g.

Most preferably, in described medicine the weight of each crude drug be respectively Fructus Gardeniae grandiflorae 25g, Radix Ophiopogonis 20g, Radix Bupleuri 15g, Fructus Jujubae 25g, Radix Aucklandiae 15g, Radix Angelicae Dahuricae 30g, Rhizoma Zingiberis 15g, Flos Inulae 15g, Cortex Phellodendri 40g, Radix Salviae Miltiorrhizae 25g, Semen Raphani 15g, Bulbus Fritillariae Thunbergii 20g, Semen Coicis 15g, careless Radix Angelicae Pubescentis 15g, melilotus 20g, Herba Galii Bungei 15g, Fructus Akebiae 15g, Fructus Chaenomelis 10g, Semen Euryales 15g, LIUYECAI 15g and gold line 10g.

Present invention also offers the preparation method of said medicine, it comprises:

The first step, water intaking Cape jasmine, Radix Bupleuri, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Cortex Phellodendri, Semen Raphani, Semen Coicis, grass Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Chaenomelis, LIUYECAI and gold line, clean respectively, pulverize, mix, obtain mixture, adding relative to mixture quality 10 ~ 20 times amount concentration is the hydrochloric acid of 0.1%, reflux, extract, 1 ~ 3 hour, filters, it is 0.1% hydrochloric acid that filtering residue adds relative to mixture quality 10 ~ 20 times amount concentration again, reflux, extract, 1 ~ 3 hour, filters, merging filtrate, being evaporated to 60 DEG C of relative densities is 1.05 ~ 1.10, obtain sour extracted extract, being cooled to room temperature, is that 10% ~ 30% sodium hydroxide is adjusted to neutrality by concentration, add ethanol again and reach 70% to alcohol content, leave standstill 6 ~ 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.05 ~ 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, uses water successively, determining alcohol is 5% ~ 30% ethanol elution, discards eluent, then is 45% ~ 55% ethanol elution with determining alcohol, and collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the first powder,

Second step, crude drug component under remainder, clean respectively, pulverize, mix, obtain mixture, add relative to mixture quality 10 ~ 20 times of water gagings, reflux, extract, 1 ~ 3 hour, filter, filtering residue adds relative to mixture quality 10 ~ 20 times of water gagings again, reflux, extract, 1 ~ 3 hour, filter, merging filtrate, at being evaporated to 60 DEG C, relative density is 1.05 ~ 1.10, obtain the water extracted immersing paste, be cooled to room temperature, add ethanol and reach 70% to alcohol content, leave standstill 6 ~ 12 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.05 ~ 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, wash with water, discard eluent, be 10% ~ 20% ethanol elution with determining alcohol again, collect eluent, decompression recycling ethanol is to dry, be ground into powder, obtain the second powder,

3rd step, by the first powder and the mixing of the second powder, add various adjunct ingredient as required, conveniently preparation method is prepared into various conventional formulation, and preferred dosage form is granule or tablet or capsule or oral liquid.

When prepared dosage form is granule; 3rd step is specially mass percent 20% ~ 30% cane sugar powder added by the powder of mixing relative to mixed-powder quality; be 75% ~ 85% ethanol soft material with determining alcohol; granulate with oscillating granulator; dry at 60 DEG C, granulate, obtains medicinal granule; splitting splendid attire, every bag of 10g.

When prepared dosage form is capsule, the 3rd step is specially gets 300g mixed-powder, adds 40g polyvidone, is distributed into capsule, each capsule 0.5g.

Each crude drug pharmacology is as follows:

Fructus Gardeniae grandiflorae: be the fruit of Rubiaceae Gardenia Ellis plant Flos Caryophylli Fructus Gardeniae, bitter in the mouth, cold in nature, there is heat-clearing and toxic substances removing, effect of reducing swelling and alleviating pain, cure mainly pyretic toxicity, jaundice, oedema due to nephritis, dampen cards such as spraining.

Radix Ophiopogonis: have another name called Radix Ophiopogonis, Radix Ophiopogonis, fragrant-flowered garlic leaf Radix Ophiopogonis, sweet in the mouth, micro-hardship, cold nature, enter the heart, lung, stomach warp, the effect having nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away to nourish heart, being mainly used in pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat to stick, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, thermal burn stomach-Yin or the dry mouth and throat caused by deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia, interior-heat is quenched one's thirst, constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and dryly wait card.

Radix Bupleuri: latin name bupleuri radix, for the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii., bitter in the mouth, cold nature, return Liver Channel, gallbladder meridian, have evacuate bring down a fever, effect of yang invigorating soothing liver-QI, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the cards such as uterus comes off, menoxenia.

Fructus Jujubae: latin name jujubae fructus, sweet in the mouth, warm in nature, return spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjust battalion to defend, separate effect of poison of drug, cure mainly insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation.Married woman's stolen goods are hot-tempered waits card.

The Radix Aucklandiae: acrid in the mouth, bitter, warm in nature, return spleen, stomach, liver, lung meridian, there are promoting the circulation of QI to relieve pain; Effect of intestinal stasis relieving in tune, cures mainly born of the same parents and coerces distension foot; Abdominal distention; Tell and have loose bowels; Heavily card is waited after dysentery.

The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, returns lung, spleen, stomach warp, has the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.

Rhizoma Zingiberis: acrid in the mouth, hot in nature, return spleen, stomach, the heart, lung meridian; Have warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, effect of warming the lung to resolve fluid-retention, and for coldness and pain in the epigastrium, vomiting, has loose bowels, the cards such as YANG-depletion is fainted inverse, and cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.

Flos Inulae: bitter in the mouth, pungent, one-tenth, slightly warm in nature, returns lung, stomach, large intestine channel, has sending down the abnormal ascending QI, expectorant, row water, the effect of preventing or arresting vomiting, and for cough due to wind and cold, phlegm retention stores knot, chest and diaphragm feeling of fullness, dyspnea and cough with excessive sputum, vomiting eructation, the cards such as epigastric oppression and rigidity.

Cortex Phellodendri: latin name Phellodendri Chinensis Cortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel, have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, and clear away heart-fire relieving restlessness, and effect of nourishing blood to tranquillize the mind, cures mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.

Semen Raphani: latin name raphani semen, property is put down, acrid in the mouth, sweet, returns lung, spleen, stomach warp, has the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm, cures mainly retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stops up cards such as breathing with cough.

Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, enter lung, heart channel, have removing heat-phlegm, effect of powder detoxifcation, cures mainly cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, the cards such as sore swollen toxin.

Semen Coicis: latin name Coicis Semen, sweet in the mouth, light, cold nature, enters lung, spleen, large intestine channel, has invigorating the spleen to arrest diarrhea, diuretic eliminating impediment, and effect of row's skin ulcer pus, curing mainly having loose bowels of wet tired lung stomach; Damp invades the hydrosarca of stain skin, dysuria; The damp and hot numbness hindered in QI and blood passes to and the scorchingly hot card such as lung abscess, acute appendicitis pented up in lung intestinal.

Grass Radix Angelicae Pubescentis: be the root of Wu Jia Ke Cortex araliae chinensis platymiscium Yunnan Radix Ariliae, bitter in the mouth, pungent, slightly warm in nature, has dispersing wind-cold, invigorating spleen for diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly anemofrigid cold, cough, edema due to deficiency of the spleen, infantile malnutrition, pain in chest and hypochondrium, treating swelling and pain by traumatic injury, rheumatalgia, lumbago, fracture, menoxenia, the cards such as traumatic hemorrhage.

Melilotus: acrid in the mouth, property is put down, and have and middle stomach invigorating, clearing away heat and eliminating dampness, effect of diuresis, cures mainly heat-damp in summer uncomfortable in chest, greasy taste in the mouth, halitosis, dysentery with red and white feces, the cards such as gonorrhea.

Herba Galii Bungei: be the herb of Rubiaceae clivers four leaf humulus, sweet in the mouth, hardship, property is put down, and have heat-clearing and toxic substances removing, effect of inducing diuresis to remove edema, cures mainly pyretic stranguria, dysentery, hemoptysis, leucorrhea with red and white discharge, infantile malnutrition, traumatic injury, the cards such as venom.

Fructus Akebiae: bitter in the mouth, cold in nature, return liver, gallbladder, stomach, urinary bladder channel, there is depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain, effect of eliminating stagnation diuresis, cure mainly gastral cavity side of body distending pain, dysmenorrhea amenorrhea, sucutaneous nodule mass in the abdomen, the cards such as dysuria.

Fructus Chaenomelis: property is put down, is slightly cold, sweet in the mouth, returns liver, spleen channel, has suppressing the hyperactive liver relaxing muscles and tendons, and effect of stomach function regulating removing dampness cures mainly arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, the cards such as beriberi edema.

Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.

LIUYECAI: be the herb of Oenotheraceae Epilobium fabric LIUYECAI, bitter in the mouth, light, cold in nature, have heat-clearing and toxic substances removing, dampness removing antidiarrheal, helps digestion and regulates the flow of vital energy, to invigorate blood circulation effect of synthetism, cure mainly damp-heat dysentery, food stagnation, abdominal distention, toothache, menoxenia, amenorrhea, leukorrhagia, injury and bone fracture, the cards such as burn and scald.

Gold line: be the herb of Gentianaceae Tripterospermum plant Hong Kong Tripterospermum affine, sweet in the mouth, pungent, cold in nature, there is heat-clearing and toxic substances removing, effect of cough-relieving hemostasis, mainly treating bronchitis, pulmonary tuberculosis hemoptysis, pneumonia, nephritis, urinary system infection, infantile hyperpyrexia, external mastitis, the cards such as traumatic hemorrhage.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 Chinese herbal medicine extracting powder 1

Water intaking Cape jasmine 25g, Radix Bupleuri 15g, Radix Angelicae Dahuricae 30g, Rhizoma Zingiberis 15g, Cortex Phellodendri 40g, Semen Raphani 15g, Semen Coicis 15g, grass Radix Angelicae Pubescentis 15g, melilotus 20g, Herba Galii Bungei 15g, Fructus Chaenomelis 10g, LIUYECAI 15g and gold line 10g, cleans respectively, pulverizes, mix, obtain mixture, adding relative to mixture quality 15 times amount concentration is the hydrochloric acid of 0.1%, reflux, extract, 3 hours, filter, it is 0.1% hydrochloric acid that filtering residue adds relative to mixture quality 15 times amount concentration again, reflux, extract, 3 hours, filters, merging filtrate, being evaporated to 60 DEG C of relative densities is 1.10, obtain sour extracted extract, being cooled to room temperature, is that 10% sodium hydroxide is adjusted to neutrality by concentration, add ethanol again and reach 70% to alcohol content, leave standstill 12 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, uses water successively, determining alcohol is 5%, 10%, 20% and 30% ethanol elution, discards eluent, then is 50% ethanol elution with determining alcohol, and collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the first powder, gets 20g Radix Ophiopogonis, Fructus Jujubae 25g, Radix Aucklandiae 15g, Flos Inulae 15g, Radix Salviae Miltiorrhizae 25g, Bulbus Fritillariae Thunbergii 20g, Fructus Akebiae 15g, Semen Euryales 15g, cleans respectively, pulverizes, mix, obtain mixture, add relative to mixture quality 15 times of water gagings, reflux, extract, 3 hours, filter, filtering residue adds relative to mixture quality 15 times of water gagings again, reflux, extract, 3 hours, filters, merging filtrate, at being evaporated to 60 DEG C, relative density is 1.10, obtains the water extracted immersing paste, is cooled to room temperature, add ethanol and reach 70% to alcohol content, leave standstill 12 hours, filter, filtrate recycling ethanol is to without alcohol taste, and at 60 DEG C, relative density is 1.10, obtains extractum before upper prop, upper macroporous adsorptive resins, wash with water, discard eluent, then be 10% and 20% ethanol elution with determining alcohol, collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the second powder, by the first powder and the mixing of the second powder, obtain Chinese herbal medicine extracting powder 1.

Embodiment 2 Chinese herbal medicine extracting powder 2

Water intaking Cape jasmine 23g, Radix Bupleuri 13g, Radix Angelicae Dahuricae 28g, Rhizoma Zingiberis 13g, Cortex Phellodendri 38g, Semen Raphani 13g, Semen Coicis 13g, grass Radix Angelicae Pubescentis 13g, melilotus 18g, Herba Galii Bungei 13g, Fructus Chaenomelis 8g, LIUYECAI 13g and gold line 8g, cleans respectively, pulverizes, mix, obtain mixture, adding relative to mixture quality 15 times amount concentration is the hydrochloric acid of 0.1%, reflux, extract, 3 hours, filter, it is 0.1% hydrochloric acid that filtering residue adds relative to mixture quality 15 times amount concentration again, reflux, extract, 3 hours, filters, merging filtrate, being evaporated to 60 DEG C of relative densities is 1.10, obtain sour extracted extract, being cooled to room temperature, is that 10% sodium hydroxide is adjusted to neutrality by concentration, add ethanol again and reach 70% to alcohol content, leave standstill 12 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, uses water successively, determining alcohol is 5%, 10%, 20% and 30% ethanol elution, discards eluent, then is 50% ethanol elution with determining alcohol, and collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the first powder, gets 18g Radix Ophiopogonis, Fructus Jujubae 23g, Radix Aucklandiae 13g, Flos Inulae 13g, Radix Salviae Miltiorrhizae 23g, Bulbus Fritillariae Thunbergii 18g, Fructus Akebiae 13g, Semen Euryales 13g, cleans respectively, pulverizes, mix, obtain mixture, add relative to mixture quality 15 times of water gagings, reflux, extract, 3 hours, filter, filtering residue adds relative to mixture quality 15 times of water gagings again, reflux, extract, 3 hours, filters, merging filtrate, at being evaporated to 60 DEG C, relative density is 1.10, obtains the water extracted immersing paste, is cooled to room temperature, add ethanol and reach 70% to alcohol content, leave standstill 12 hours, filter, filtrate recycling ethanol is to without alcohol taste, and at 60 DEG C, relative density is 1.10, obtains extractum before upper prop, upper macroporous adsorptive resins, wash with water, discard eluent, then be 10% and 20% ethanol elution with determining alcohol, collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the second powder, by the first powder and the mixing of the second powder, obtain Chinese herbal medicine extracting powder 2.

Embodiment 3 Chinese herbal medicine extracting powder 3

Water intaking Cape jasmine 27g, Radix Bupleuri 17g, Radix Angelicae Dahuricae 32g, Rhizoma Zingiberis 17g, Cortex Phellodendri 42g, Semen Raphani 17g, Semen Coicis 17g, grass Radix Angelicae Pubescentis 17g, melilotus 22g, Herba Galii Bungei 17g, Fructus Chaenomelis 12g, LIUYECAI 17g and gold line 12g, cleans respectively, pulverizes, mix, obtain mixture, adding relative to mixture quality 15 times amount concentration is the hydrochloric acid of 0.1%, reflux, extract, 3 hours, filter, it is 0.1% hydrochloric acid that filtering residue adds relative to mixture quality 15 times amount concentration again, reflux, extract, 3 hours, filters, merging filtrate, being evaporated to 60 DEG C of relative densities is 1.10, obtain sour extracted extract, being cooled to room temperature, is that 10% sodium hydroxide is adjusted to neutrality by concentration, add ethanol again and reach 70% to alcohol content, leave standstill 12 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, uses water successively, determining alcohol is 5%, 10%, 20% and 30% ethanol elution, discards eluent, then is 50% ethanol elution with determining alcohol, and collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the first powder, gets 22g Radix Ophiopogonis, Fructus Jujubae 27g, Radix Aucklandiae 17g, Flos Inulae 17g, Radix Salviae Miltiorrhizae 27g, Bulbus Fritillariae Thunbergii 22g, Fructus Akebiae 17g, Semen Euryales 17g, cleans respectively, pulverizes, mix, obtain mixture, add relative to mixture quality 15 times of water gagings, reflux, extract, 3 hours, filter, filtering residue adds relative to mixture quality 15 times of water gagings again, reflux, extract, 3 hours, filters, merging filtrate, at being evaporated to 60 DEG C, relative density is 1.10, obtains the water extracted immersing paste, is cooled to room temperature, add ethanol and reach 70% to alcohol content, leave standstill 12 hours, filter, filtrate recycling ethanol is to without alcohol taste, and at 60 DEG C, relative density is 1.10, obtains extractum before upper prop, upper macroporous adsorptive resins, wash with water, discard eluent, then be 10% and 20% ethanol elution with determining alcohol, collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the second powder, by the first powder and the mixing of the second powder, obtain Chinese herbal medicine extracting powder 3.

Embodiment 4 toxicology test

Choose ICR mice 60, be divided into blank group and treatment group, often organize 30.

Experimental agents

Granule 1 prepared by the mouse stomach embodiment of the present invention 1.

Mouse Acute Toxicity is tested

By treatment group mice according to method administration above, Chinese herbal medicine extracting powder dissolution embodiment 1 prepared is in water, be prepared into the solution gavage of 1g/ml, each gavage 0.8ml/10g, blank group gavage normal saline, before test after fasting (can't help water) 12h, treatment group 1 gastric infusion every day, continuous 14d, the situations such as the behavior of record test mice, activity, food ration, body weight, feces, death, not dead mice is put to death and performs an autopsy on sb. after 14d.

The mice of Chinese herbal medicine extracting powder 80g (crude drug)/kg dosed administration, saw that mice hair color was smooth, feces is brown the same day, quality is rarer soft, ingest, movable less, mice activity after 2nd day, food ration, body weight growth, feces etc. all recover normally, to compare no significant difference with blank group; And in 14d without dead and other extremely to occur, two groups put to death simultaneously after perform an autopsy on sb., each main organs (heart, liver, spleen, lung, kidney) no abnormality seen by the naked eye.

Cavia porcellus repetitively administered toxicity test

The Chinese herbal medicine extracting powder 1 embodiment 1 prepared is dissolved in water, be prepared into the solution of 1g/ml, by administration group Cavia porcellus according to method administration above, each 0.8ml/10g, blank group gavage normal saline, before test after fasting (can't help water) 12h, treatment group 1 gastric infusion every day, continuous 5 weeks, record the situations such as tested Cavia porcellus behavior, activity, food ration, body weight, feces, death, non-Guinea Pigs Died was put to death and is performed an autopsy on sb. after 5 weeks.

Experimental animal behavioral activity, diet, defecation and shown no obvious abnormalities by situations such as hair color pools within whole experimental period, have no vomiting, sialorrhea, shed tears, the symptom such as dyspnea.Duration of test has individual animal dead, and take up Anatomical Observation through cage, dead animal shows no obvious abnormalities, for administration is improper lethal.

After the administration of administration treated animal, growth promoter is good, and body weight increases to compare with blank group and shows no obvious abnormalities.

Animal is put to death after off-test, dissect immediately, the major organs such as perusal brain, heart, liver, spleen, lungs, kidney, each organ surface is smooth, without adhesion, color and luster is normal, has no hyperemia, swelling, hemorrhage, downright bad, adhesion, gastrointestinal is without expansion, and intestinal wall is without abnormal phenomenas such as edema, hemorrhage, ulcer.

Heart: myocardial cell band is clear, core is placed in the middle, and interstitial has no vasodilation and cell infiltration; Visceral pericardium, endocardium are without exception.Liver: hepatocyte arrangement is in strand, and lobules of liver structure is clear, and portal area has no cell infiltration and fibrous connective tissue hypertrophy, hepatocyte polygon, and slurry is abundant, core is large and justify.Spleen: fibrous capsule is complete, without thickening, acini lienalis is high-visible, and trabecularism is normal, and red pulp, white pulp are clear, have no degeneration, necrosis and cell infiltration.Lungs: bronchioles structural integrity, is methodically arranged, alveolar wall structural integrity, lung interval and bronchus stand intact, and intracavity, without obvious exudate, has no degeneration, necrosis and cell infiltration.Kidney: Renal Cortex, medullary substance, glomerule structure are normal, and messangial cell number does not increase, blood capillary tube chamber without expansion, renal cells, renal interstitial no abnormality seen.Brain: organizational structure is normal, neurocyte, neurogliocyte form are normal, each layer neuronal cell Non Apparent Abnormality.

Above-mentioned test proves Chinese herbal medicine extracting powder avirulence provided by the invention, is suitable for safety applications.

Embodiment 5 granule

Chinese herbal medicine extracting powder embodiment 1 prepared adds mass percent 20% cane sugar powder relative to its quality, is 85% ethanol soft material, granulates with oscillating granulator with determining alcohol; dry at 60 DEG C, granulate, obtains medicinal granule; splitting splendid attire, every bag of 10g.

Embodiment 6 capsule

Chinese herbal medicine extracting powder 300g prepared by Example 1, adds 40g polyvidone, is distributed into capsule, each capsule 0.5g.

Embodiment 7 clinical data

Object: year JIUYUE my institute's Integrated TCM & Western Medicine Dept. in June, 2011 ~ 2014 are in hospital or outpatient 220 example, man 109 example, female 111 example; 22 ~ 61 years old age, average 38.5 years old; Course of disease July ~ 21 month.All patients all has reflux symptom, is diagnosed as reflux esophagitis through fibergastroscope.

Diagnosis basis: burn feeling under xiphoid-process, esophagus sensation of pricking when swallowing food, retrosternal pain, dysphagia, reflux.Gastroscopy is made a definite diagnosis: in esophagus, the hyperemia of hypomere mucosa, edema, ooze out, rotten to the corn or have shallow table aphtha.And chest pain, esophagus, stomach and the Tumors of Duodenum got rid of caused by heart and lung diseases and ulcer.

Endoscopic diagnosis and classification: formulate (1999 Yantai) according to national reflux esophageal disease and esophagitis seminar; 0 grade: normal (change can be learned in a organized way), integration 0; 1 grade: point-like or strip rubescent, rotten to the corn, amixis phenomenon, integration 1; 2 grades: have strip rubescent, rotten to the corn, and have fusion, but non-all-round property, integration 2; 3 grades: pathological changes is extensive, rubescent, rotten to the corn fusion is all-round property, or ulcer, integration 3.

Therapeutic Method: case is divided into two groups at random, is respectively treatment group and matched group, treatment group 110 example, man 53 example, female 56 example, matched group 110 example, man 56 example, female 55 example, treatment group takes granule prepared by the embodiment of the present invention 5, be dissolved in wet suit use, every day 2 doses, each 1 dose sooner or later, every agent 10g, takes before the meal, the matched group every day of the western quinoline 10mg of 30min clothes before the meal, 3 times/d, omeprazole every day early before the meal 30min take 20mg.4 weeks courses for the treatment of, each patient before the treatment after observed by same doctor.Gastroscope is checked, curative effect evaluation after 4 weeks.Before treatment, grouping case-data is poor without significance.

Criterion of therapeutical effect: integration 0 grade of person of endoscope's check is recovery from illness; Scope integration reduces by 2 points of persons for effective; Integration reduces 1 and is divided into effectively; Integration unchanged or increase by more than 1 point be invalid.

Patient is rear each blood drawing one-time detection motilin, gastrin before the treatment, and sets Healthy People 30 example as Normal group.In venous blood samples 2ml on an empty stomach in early morning, separation of serum, measured by radioimmunoassay rami gastrici element, gastrin content.Gastrin, motilin medicine box adopt East Asia immunological technique institute product, variation within batch CV < 10%, batch variation CV < 15%, the equal by specification method operation of experimental technique, measures with FJ-2008ps γ radiation immunity arithmometer (Xi'an nuclear instrument factory).

Statistical method

Use SPSS15.0 statistical software carry out analyzing and processing, measurement data with (average ± standard deviation) represents, person adopts t to check to meet normal distribution, and person adopts rank test not meet normal distribution, and enumeration data adopts X ²inspection, with P < 0.05 for difference has statistical significance.

Result

Two groups of Clinical efficacy comparisons, the results are shown in Table 1.

Table 1 liang group Clinical efficacy comparison

Group	n	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Treatment group	110	49	26	12	23	79.1％
Matched group	110	45	22	14	29	73.6％

With endoscopic findings Estimating curative effect, curative effect at different levels is after 4 weeks, curative effect in table 1, adopt the effect of medicine provided by the invention in treatment reflux esophagitis comparatively Western medicine slightly well, both differences are not remarkable.

The comparison of two groups of patients serum's motilins, gastrin, the results are shown in Table 2.

The comparison (pg/ml) of table 2 liang group patients serum motilin, gastrin

Serum motilin and the Gastrin Levels of patients with reflux esophagitis are starkly lower than Normal group, adopt Chinese medicine and Western medicine can increasing serum motilin and Gastrin Levels to some extent, and it is better with the effect for the treatment of group, be better than matched group, difference has statistical significance (P < 0.05).

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. be used for the treatment of a medicine for reflux esophagitis, it is characterized in that: crude drug comprises Fructus Gardeniae grandiflorae, Radix Ophiopogonis, Radix Bupleuri, Fructus Jujubae, the Radix Aucklandiae, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Flos Inulae, Cortex Phellodendri, Radix Salviae Miltiorrhizae, Semen Raphani, Bulbus Fritillariae Thunbergii, Semen Coicis, careless Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Akebiae, Fructus Chaenomelis, Semen Euryales, LIUYECAI and gold line.

2. medicine as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Fructus Gardeniae grandiflorae 20g ~ 30g, Radix Ophiopogonis 15g ~ 25g, Radix Bupleuri 10g ~ 20g, Fructus Jujubae 20g ~ 30g, Radix Aucklandiae 10g ~ 20g, Radix Angelicae Dahuricae 25g ~ 35g, Rhizoma Zingiberis 10g ~ 20g, Flos Inulae 10g ~ 20g, Cortex Phellodendri 35g ~ 45g, Radix Salviae Miltiorrhizae 20g ~ 30g, Semen Raphani 10g ~ 20g, Bulbus Fritillariae Thunbergii 15g ~ 25g, Semen Coicis 10g ~ 20g, grass Radix Angelicae Pubescentis 10g ~ 20g, melilotus 15g ~ 25g, Herba Galii Bungei 10g ~ 20g, Fructus Akebiae 10g ~ 20g, Fructus Chaenomelis 5g ~ 15g, Semen Euryales 10g ~ 20g, LIUYECAI 10g ~ 20g and gold line 5g ~ 15g.

3. medicine as claimed in claim 1 or 2, it is characterized in that: the weight of each crude drug is respectively Fructus Gardeniae grandiflorae 23g ~ 27g, Radix Ophiopogonis 18g ~ 22g, Radix Bupleuri 13g ~ 17g, Fructus Jujubae 23g ~ 27g, Radix Aucklandiae 13g ~ 17g, Radix Angelicae Dahuricae 28g ~ 32g, Rhizoma Zingiberis 13g ~ 17g, Flos Inulae 13g ~ 17g, Cortex Phellodendri 38g ~ 42g, Radix Salviae Miltiorrhizae 23g ~ 27g, Semen Raphani 13g ~ 17g, Bulbus Fritillariae Thunbergii 18g ~ 22g, Semen Coicis 13g ~ 17g, grass Radix Angelicae Pubescentis 13g ~ 17g, melilotus 18g ~ 22g, Herba Galii Bungei 13g ~ 17g, Fructus Akebiae 13g ~ 17g, Fructus Chaenomelis 8g ~ 12g, Semen Euryales 13g ~ 17g, LIUYECAI 13g ~ 17g and gold line 8g ~ 12g.

4. the preparation method of medicine described in claims 1 to 3, is characterized in that, comprising:

The first step, water intaking Cape jasmine, Radix Bupleuri, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Cortex Phellodendri, Semen Raphani, Semen Coicis, careless Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Chaenomelis, LIUYECAI and gold line, adopt concentration to be that 0.1% hydrochloric acid solution extracts, extracting solution purification, reclaim under reduced pressure, obtains dry first powder;

Second step, goes remaining crude drug component, and adopt water extraction, extracting solution purification, reclaim under reduced pressure, obtains dry second powder;

3rd step, by the first powder and the mixing of the second powder, add various adjunct ingredient as required, conveniently preparation method is prepared into various conventional formulation.

5. the preparation method of medicine as claimed in claim 4, is characterized in that: the described first step is specially further, water intaking Cape jasmine, Radix Bupleuri, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Cortex Phellodendri, Semen Raphani, Semen Coicis, grass Radix Angelicae Pubescentis, melilotus, Herba Galii Bungei, Fructus Chaenomelis, LIUYECAI and gold line, clean respectively, pulverize, mix, obtain mixture, adding relative to mixture quality 10 ~ 20 times amount concentration is the hydrochloric acid of 0.1%, reflux, extract, 1 ~ 3 hour, filters, it is 0.1% hydrochloric acid that filtering residue adds relative to mixture quality 10 ~ 20 times amount concentration again, reflux, extract, 1 ~ 3 hour, filters, merging filtrate, being evaporated to 60 DEG C of relative densities is 1.05 ~ 1.10, obtain sour extracted extract, being cooled to room temperature, is that 10% ~ 30% sodium hydroxide is adjusted to neutrality by concentration, add ethanol again and reach 70% to alcohol content, leave standstill 6 ~ 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.05 ~ 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, uses water successively, determining alcohol is 5% ~ 30% ethanol elution, discards eluent, then is 45% ~ 55% ethanol elution with determining alcohol, and collect eluent, decompression recycling ethanol, to dry, pulverize powdered, obtains the first powder.

6. the preparation method of medicine as described in claim 4 or 5, it is characterized in that: described second step is specially further, crude drug component under remainder, clean respectively, pulverize, mix, obtain mixture, add relative to mixture quality 10 ~ 20 times of water gagings, reflux, extract, 1 ~ 3 hour, filter, filtering residue adds relative to mixture quality 10 ~ 20 times of water gagings again, reflux, extract, 1 ~ 3 hour, filter, merging filtrate, at being evaporated to 60 DEG C, relative density is 1.05 ~ 1.10, obtain the water extracted immersing paste, be cooled to room temperature, add ethanol and reach 70% to alcohol content, leave standstill 6 ~ 12 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, and relative density is 1.05 ~ 1.10 at 60 DEG C, extractum before upper prop, upper macroporous adsorptive resins, wash with water, discard eluent, be 10% ~ 20% ethanol elution with determining alcohol again, collect eluent, decompression recycling ethanol is to dry, be ground into powder, obtain the second powder.

7. the preparation method of medicine as described in claim 4 to 6; it is characterized in that: when prepared dosage form is granule; 3rd step is specially mass percent 20% ~ 30% cane sugar powder added by the powder of mixing relative to mixed-powder quality; be 75% ~ 85% ethanol soft material with determining alcohol, granulate with oscillating granulator, dry at 60 DEG C; granulate; obtain medicinal granule, splitting splendid attire, every bag of 10g.

8. the preparation method of medicine as described in claim 4 to 7, it is characterized in that: when prepared dosage form is capsule, the 3rd step is specially gets 300g mixed-powder, adds 40g polyvidone, is distributed into capsule, each capsule 0.5g.