CN105434670A

CN105434670A - Traditional Chinese medicine preparation for treating costal chondritis and preparation method thereof

Info

Publication number: CN105434670A
Application number: CN201610013306.XA
Authority: CN
Inventors: 姜达志
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-10
Filing date: 2016-01-10
Publication date: 2016-03-30

Abstract

The invention provides a traditional Chinese medicine preparation for treating costal chondritis and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following raw medicinal materials: geaster, gelidium amansii lamx., bombardier beetle, littleleaf willow root and leaf, champion bauhinia seed, hairyshoot elm bark, purslane speedwell herb, huechys, lycopodium obscurum, daphne odera, beefwood-like clubmoss herb, Japanese polypody rhizome, red nanmu bark, fragrant sarcococca root, lamiophlomis rotata hudo., oblongleaf kadsura stem or root, pummelo flower, adenosma indianum, micromelum integerrimum, cholla stem, hairy chestnut root, plum blossom, Chinese wampee seed, water pepper, physalis angulata, dindygulen peperomia herb, bistort rhizome and rock cotoneaster leaf or root. The traditional Chinese medicine preparation for treating costal chondritis provided by the invention has a better treatment effect on costal chondritis by combining with Western medicines, has no toxic and side effects and adverse reactions, and a preparation process is simple.

Description

A kind of Chinese medicine preparation for the treatment of costal chondritis and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation for the treatment of costal chondritis and preparation method thereof.

Background technology

Costal chondritis refers to the chronic nonspecific inflammation occurring in costicartilage position, also known as apyetous costal chondritis.Costicartilage hypertrophy its etiology unknown sick, it is generally acknowledged with strain or wound relevant, at people's carrying heavy goods, sharply reverse or make sternocostal joints cartilage cause acute injury because of Chest compressions etc., or the viral infection etc. to cause because of chronic strain or Common Cold, cause the edema of the thin-skinned bone of sternocostal joints, the aseptic inflammation thickened reacts and falls ill.Its feature is that costicartilage has the swelling of pain property, the most common with 2-7 costicartilage junction.Be generally multiple, but also can occur in a costicartilage, the common second rib of single originator.There are swelling, pain in clinical visible costicartilage place, deeply breathe, cough or extruding thoracic wall time pain increase the weight of.Pain property lump can be touched to obtain by costicartilage place, and local temperature can raise, but skin is not red.A succession of swelling can be had in breastbone both sides.Primary disease is mainly in adult, and women is in the majority.The main cause that costal chondritis is gone to a doctor is the thoracic wall localized pain of unknown cause, the costicartilage limitation swelling at visible sternocostal joints place during inspection, protuberance, tenderness is obvious, especially movable with upper limb, cough, the pain increased when leaning to one side, the motion so that patient dare not breathe deeply.The course of disease is different in size, often delays the several months, even the several years.Some patients's symptom can spontaneous remission, but normal recurrent exerbation, and x-ray inspection without diagnostic value, but can get rid of thoracic cavity, cardiopulmonary or other organic diseases to primary disease.If bump surface is rough, enlargement is very fast, should be differentiated with coostochondrosarcoma.

Costal chondritis belongs to the category of motherland's medical science " thoracic obstruction ", can betide all costicartilages, but common with 2-6 costicartilage.The morbidity of primary disease winter-spring season is more, and women is more than male, especially common with young women and many with menoxenia.The generation of primary disease may the factor such as, endocrine dysfunction uncomfortable with feelings will relevant.Motherland's medical science thinks that sternocostal part is that gallbladder Liver Channel follows row position, and frustrate in sternocostal part, the invasion such as disorder of emotion or wind-cold damp pathogen causes the expectorant stasis of blood and hand over resistance, stagnation of QI and blood, blockage of main and collateral channels, chest mechanism of qi is obstructed, stagnation of QI and blood may bring about pain, is the pathomechanism of primary disease.

Summary of the invention

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of determined curative effect and Chinese medicine preparation of the little treatment costal chondritis of toxic action and preparation method thereof.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of costal chondritis, described Chinese medicine preparation comprises following raw medicinal material: geaster, Eucheuma gelatinosum, Pheropsophus jessoensis Mor., Radix Salicis Hypoleucae, Semen Bauhiniae championii, Cortex Ulmi virgatae, purslane speedwell Herba, Huechys sanguinea De Geer., Herba Lycopodii Obscuri, Radix Buddlejae Butterflybush, Lycopodium casuarinoides Spring, Rhizoma Polypodiodis Nipponicae, Cortex Machili Thunbergii Radicis, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Radix Lamiophlomidis Rotatae, Caulis Seu Radix Kadsurae Oblongifoliae, Flos Citri grandis, Herba Adenosmae Glutinosi, Radix Micromeli Integerrimi, Radix et Caulis Opuntiae Dillenii, Radix Castaneae, Flos Mume, Semen clausenae lansii, Herba Polygoni hydropiperis, Herba Physalis pubescentis, Herba Peperomiae Dindygulensis, Rhizoma Bistortae and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis).

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: geaster 5 ~ 15 parts, Eucheuma gelatinosum 15 ~ 25 parts, Pheropsophus jessoensis Mor. 25 ~ 35 parts, Radix Salicis Hypoleucae 10 ~ 20 parts, Semen Bauhiniae championii 15 ~ 30 parts, Cortex Ulmi virgatae 30 ~ 40 parts, purslane speedwell Herba 15 ~ 25 parts, Huechys sanguinea De Geer. 15 ~ 30 parts, Herba Lycopodii Obscuri 25 ~ 35 parts, Radix Buddlejae Butterflybush 5 ~ 15 parts, Lycopodium casuarinoides Spring 25 ~ 35 parts, Rhizoma Polypodiodis Nipponicae 10 ~ 20 parts, Cortex Machili Thunbergii Radicis 15 ~ 25 parts, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 30 ~ 40 parts, Radix Lamiophlomidis Rotatae 10 ~ 25 parts, Caulis Seu Radix Kadsurae Oblongifoliae 20 ~ 30 parts, Flos Citri grandis 25 ~ 35 parts, Herba Adenosmae Glutinosi 5 ~ 15 parts, Radix Micromeli Integerrimi 10 ~ 20 parts, Radix et Caulis Opuntiae Dillenii 15 ~ 25 parts, Radix Castaneae 20 ~ 30 parts, 5 ~ 15 parts, Flos Mume, Semen clausenae lansii 25 ~ 35 parts, Herba Polygoni hydropiperis 10 ~ 20 parts, Herba Physalis pubescentis 15 ~ 25 parts, Herba Peperomiae Dindygulensis 30 ~ 40 parts, Rhizoma Bistortae 5 ~ 15 parts and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 15 ~ 30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: geaster 10 ~ 15 parts, Eucheuma gelatinosum 20 ~ 25 parts, Pheropsophus jessoensis Mor. 30 ~ 35 parts, Radix Salicis Hypoleucae 15 ~ 20 parts, Semen Bauhiniae championii 20 ~ 25 parts, Cortex Ulmi virgatae 30 ~ 35 parts, purslane speedwell Herba 15 ~ 20 parts, Huechys sanguinea De Geer. 25 ~ 30 parts, Herba Lycopodii Obscuri 30 ~ 35 parts, Radix Buddlejae Butterflybush 5 ~ 10 parts, Lycopodium casuarinoides Spring 25 ~ 30 parts, Rhizoma Polypodiodis Nipponicae 10 ~ 15 parts, Cortex Machili Thunbergii Radicis 20 ~ 25 parts, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 30 ~ 35 parts, Radix Lamiophlomidis Rotatae 15 ~ 20 parts, Caulis Seu Radix Kadsurae Oblongifoliae 25 ~ 30 parts, Flos Citri grandis 30 ~ 35 parts, Herba Adenosmae Glutinosi 5 ~ 10 parts, Radix Micromeli Integerrimi 15 ~ 20 parts, Radix et Caulis Opuntiae Dillenii 20 ~ 25 parts, Radix Castaneae 25 ~ 30 parts, 5 ~ 10 parts, Flos Mume, Semen clausenae lansii 25 ~ 30 parts, Herba Polygoni hydropiperis 10 ~ 15 parts, Herba Physalis pubescentis 20 ~ 25 parts, Herba Peperomiae Dindygulensis 30 ~ 35 parts, Rhizoma Bistortae 10 ~ 15 parts and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 15 ~ 20 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: geaster 12 parts, Eucheuma gelatinosum 25 parts, Pheropsophus jessoensis Mor. 31 parts, Radix Salicis Hypoleucae 19 parts, Semen Bauhiniae championii 21 parts, Cortex Ulmi virgatae 35 parts, purslane speedwell Herba 16 parts, Huechys sanguinea De Geer. 28 parts, Herba Lycopodii Obscuri 31 parts, Radix Buddlejae Butterflybush 10 parts, Lycopodium casuarinoides Spring 26 parts, Rhizoma Polypodiodis Nipponicae 15 parts, Cortex Machili Thunbergii Radicis 21 parts, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 35 parts, Radix Lamiophlomidis Rotatae 16 parts, Caulis Seu Radix Kadsurae Oblongifoliae 29 parts, Flos Citri grandis 32 parts, Herba Adenosmae Glutinosi 10 parts, Radix Micromeli Integerrimi 17 parts, Radix et Caulis Opuntiae Dillenii 25 parts, Radix Castaneae 26 parts, 10 parts, Flos Mume, Semen clausenae lansii 26 parts, Herba Polygoni hydropiperis 15 parts, Herba Physalis pubescentis 21 parts, Herba Peperomiae Dindygulensis 35 parts, Rhizoma Bistortae 12 parts and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 19 parts.

When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

The first step, geaster, Eucheuma gelatinosum, Pheropsophus jessoensis Mor., Radix Salicis Hypoleucae, Semen Bauhiniae championii, Cortex Ulmi virgatae, purslane speedwell Herba, Huechys sanguinea De Geer., Herba Lycopodii Obscuri, Radix Buddlejae Butterflybush, Lycopodium casuarinoides Spring, Rhizoma Polypodiodis Nipponicae, Cortex Machili Thunbergii Radicis, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Radix Lamiophlomidis Rotatae and Caulis Seu Radix Kadsurae Oblongifoliae are mixed in proportion, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 ~ 4 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 8 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.01 ~ 0.02; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;

5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1 ~ 3: 0.15 ~ 0.3.

When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, geaster, Eucheuma gelatinosum, Pheropsophus jessoensis Mor., Radix Salicis Hypoleucae, Semen Bauhiniae championii, Cortex Ulmi virgatae, purslane speedwell Herba, Huechys sanguinea De Geer., Herba Lycopodii Obscuri and Radix Buddlejae Butterflybush are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Lycopodium casuarinoides Spring, Rhizoma Polypodiodis Nipponicae, Cortex Machili Thunbergii Radicis, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Radix Lamiophlomidis Rotatae, Caulis Seu Radix Kadsurae Oblongifoliae, Flos Citri grandis, Herba Adenosmae Glutinosi, Radix Micromeli Integerrimi and Radix et Caulis Opuntiae Dillenii are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

Beneficial effect of the present invention: the Chinese medicine preparation that costal chondritis of the present invention uses, combined with westem treatment costal chondritis, therapeutic effect is better, and have no side effect and untoward reaction, preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of costal chondritis, Chinese medicine preparation comprises following raw medicinal material: geaster, Eucheuma gelatinosum, Pheropsophus jessoensis Mor., Radix Salicis Hypoleucae, Semen Bauhiniae championii, Cortex Ulmi virgatae, purslane speedwell Herba, Huechys sanguinea De Geer., Herba Lycopodii Obscuri, Radix Buddlejae Butterflybush, Lycopodium casuarinoides Spring, Rhizoma Polypodiodis Nipponicae, Cortex Machili Thunbergii Radicis, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Radix Lamiophlomidis Rotatae, Caulis Seu Radix Kadsurae Oblongifoliae, Flos Citri grandis, Herba Adenosmae Glutinosi, Radix Micromeli Integerrimi, Radix et Caulis Opuntiae Dillenii, Radix Castaneae, Flos Mume, Semen clausenae lansii, Herba Polygoni hydropiperis, Herba Physalis pubescentis, Herba Peperomiae Dindygulensis, Rhizoma Bistortae and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis).

The pharmacology of various raw medicinal material is as follows:

Geaster: [another name] ground Aranea, Saturn bacterium, large orphan, Geastrum hygrometricum Pers., Fossilia Brachyurae.[source] medical material Ji Yuan: be the sporophore of geaster section fungus sclerderm geaster and Geastrum triplex (Jungh, Fischer).[nature and flavor] are pungent; Property is put down.[function cures mainly] lung heat clearing; Sore-throat relieving; Removing toxic substances; Detumescence; Hemostasis.Main cough; Laryngopharynx swelling and pain; Carbuncle sore tumefacting virus; Chilblain flowing water; Spit blood; Epistaxis; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Eucheuma gelatinosum: [another name] Eucheuma gelatinosum, Parmelia saxatilis Ach. grass, snowflake dish, phoenix tail, Herba Pileae Scriptae.[source] medical material Ji Yuan: be the frond of Gelidiaceae phytobezoar Herba Astragali Sinici, fine, soft fur Eucheuma gelatinosum, pacific gelidium etc.[nature and flavor] are sweet; Salty; Cold; Sliding; Nontoxic.[return through] liver; Lung meridian.[function cures mainly] heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Laxation; Drive ascarid.Main enteritis, diarrhea; Pyelonephritis; Goiter; Tumor; Bleeding hemorrhoids; Chronic constipation; Ascarid is disease early.[each discussion] " book on Chinese herbal medicine is just read ": lung heat clearing portion heat-phlegm, leads wet-heat of intestines, the cards such as the deficiency of YIN is damp and hot, hemorrhoidal bleeding, all can use it.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Pheropsophus jessoensis Mor.: [another name] bears dish, wind dish, night flight or navigation, wind dish worm.[source] medical material Ji Yuan: be the Scorpio of Carabidae animal tiger spot step (worm first).[nature and flavor] acrid in the mouth; Warm in nature.[return through] Liver Channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Antalgic.Main cold stasis of blood amenorrhea; Dysmenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury stasis of blood pain.Not [each discussion] " not Lu ": treat stomachache, cold and heat, sharp blood.[extracts] " China's book on Chinese herbal medicine "

Radix Salicis Hypoleucae: [another name] Salix tetradenia Hand.-Mazz., Fructus Mume wax.[source] medical material Ji Yuan: be root or the leaf of Salicaceous Plants Radix Salicis Hypoleucae.[nature and flavor] are pungent; Warm in nature.[return through] Liver Channel.[function cures mainly] expelling wind and removing dampness; Blood circulation promoting and blood stasis dispelling.Main rheumatic ostalgia; Impairment caused by overstrain.[extracts] " China's book on Chinese herbal medicine "

Semen Bauhiniae championii: [source] medical material Ji Yuan: be the seed of leguminous plant Caulis Bauhihiae Championii.[nature and flavor] toil; Temperature.[return through] liver; Stomach warp.[function cures mainly] promoting the circulation of QI to relieve pain; Blood circulation promoting and blood stasis dispelling.Main distending pain over the hypochondrium, gastric abscess, traumatic injury.[each discussion] 1. " south of the Five Ridges gather medicinal herbs record ": only pain due to disorder of QI, reason traumatic injury wound, eliminating blood stasis to promote regeneration of blood.2. " SHENGCAO medicine handbook ": gynecological disappears strongly fragrant pain due to disorder of QI, liver is had a stomachache.[extracts] " China's book on Chinese herbal medicine "

Cortex Ulmi virgatae: [another name] Radix Ulmi Tonkinesis.[source] medical material Ji Yuan: be the bark of Ulmaceae hair elm.[nature and flavor] are bitter; Puckery; Property is put down.[function cures mainly] blood circulation promoting and blood stasis dispelling; Hemostasis and pain-relieving.Main fracture; Traumatic pain; Traumatic hemorrhage; Gastrointestinal hemorrhage; Hematuria.[extracts] " China's book on Chinese herbal medicine "

Purslane speedwell Herba: [another name] Hygrophila salicifolia, Ying Taocao, peento grass, Herba Veronicae peregrinae, calm grass.[source] medical material Ji Yuan: be the herb of goatweed grave Herba Linderniae Crustaceae band insect gall.[return through] liver; Stomach; Lung meridian.[function cures mainly] removing stasis to stop bleeding; Clearing heat for detumescence; Pain relieving.Main traumatic injury; Laryngopharynx swelling and pain; Ulcer sores; Hemoptysis; Spit blood; Epistaxis; Tripe peratodynia; Colicky; Dysmenorrhea.[extracts] " China's book on Chinese herbal medicine "

Huechys sanguinea De Geer.: [another name] huechys, Calyx Seu Fructus Physalis, red Cicadae.[source] medical material Ji Yuan: be the entirety of Cicadidae animal Huechys sanguinea, brachypterism Huechys sanguinea De Geer., brown wing Huechys sanguinea De Geer..[nature and flavor] bitter in the mouth; Pungent; Property is put down.[return through] heart; Liver; Gallbladder meridian.[function cures mainly] removing blood stasis with potent drugs; Eliminating stagnation; Rose poison.Main blood stasis amenorrhea; Lumbago; Infertile scrofula; Tinea skin ulcer; Lyssodexis.[each discussion] 1. Shennong's Herbal: main trusted subordinate's pathogen, impotence.2. " Mingyi Bielu ": treat lumbago, the therapeutic method to keep the adverse QI flowing downwards.[extracts] " China's book on Chinese herbal medicine "

Herba Lycopodii Obscuri: [another name] jade then, cypress in thousand, Herba Lycopodii pulcherrimi, Herba Lycopodii, Lycopodium casuarinoides Spring.[source] medical material Ji Yuan: be the herb of lycopsid Herba Lycopodii Obscuri Lycopodium clavatum.[nature and flavor] acid; Temperature; Nontoxic.[return through] lung; Kidney channel.[function cures mainly] expelling wind and removing dampness; Channels sootheing and network vessel quickening; Blood circulation promoting and blood stasis dispelling.Main air pain of dampness syndrome; Lumbago and skelalgia; Numb limbs and tense tendons; Osteopatia sprain; Poliomyelitis sequela.[each discussion] " not Lu ": QI invigorating, quenches the thirst.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Buddlejae Butterflybush: [another name] MANSHANXIANG.[source] medical material Ji Yuan: be root, the leaf of Pittosporaceae plant platform Qionghai paulownia.[function cures mainly] promoting blood circulation and detumescence, removing toxic substances dysentery relieving.Main traumatic injury, dysentery.[each discussion] 1. " conventional glossary of Herbs and Drugs among the people ": QI and blood regulating, logical menstruation.2. " Traditional Chinese Medicine in Sichuan will ": activating blood circulation.[extracts] " China's book on Chinese herbal medicine "

Lycopodium casuarinoides Spring: [another name] Radix Stephaniae Japonicae, Fructus Seu Herba Pubescentis, Herba Lycopodii, SONGJINTENG, Tacca chantrieri Andre, catbrier.[source] medical material Ji Yuan: be the herb of lycopsid rattan Lycopodium clavatum.[nature and flavor] temperature; Micro-sweet; Nontoxic.[return through] liver; Kidney channel.[function cures mainly] expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Improving eyesight; Removing toxic substances.Main rheumatic arthritis; Traumatic injury; Bones and muscles pain; Menoxenia; Tetany; Nyctalopia; Night sweat; Lumbago due to pathogenic wind-dampness; Lumbar muscle strain; Burn due to hot liquid or fire; Sore swollen toxin.[each discussion] 1. " Traditional Chinese Medicine in Sichuan will ": can relaxing muscles and tendons to promote blood circulation.Dispelling the wind and dampness pathogens arthralgia, traumatic injury, bones and muscles pain, menoxenia and tetany.2. " the practical Chinese herbal medicine in Guangxi newly selects ": relaxing muscles and tendons and activating QI and blood in the collateral, antiinflammatory dehumidifies.Cure mainly nyctalopia, night sweat, lumbago due to pathogenic wind-dampness, infantile fever caused by exogenous pathogens.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Rhizoma Polypodiodis Nipponicae: [another name] Rhizoma Humatae Tyermanni, cordierite lotus, der Kapaun tail, Herba Scindapsi Officinalis, blue veins, Conclaves grass.[source] medical material Ji Yuan: be the rhizome of Plants of Polypodiaceae Rhizoma Polypodiodis Nipponicae.[nature and flavor] are bitter; Cool.[return through] heart; Liver; Lung meridian.[function cures mainly] clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral.Main acute diseases such as cholera and sunstroke stranguria with turbid discharge; Have loose bowels; Rheumatic arthralgia; Traumatic injury.[each discussion] 1. " Guizhou folk medicine ": soothing the channels and quicking the network vessels, pain relieving, cough-relieving.2. " register planted by Guangxi medicine ": synthetism, loose blood, controls dysentery.3. " Shaanxi Chinese herbal medicine ": promoting flow of QI and blood, detumescence dissipating blood stasis.Control traumatic injury, impairment caused by overstrain, lumbago and skelalgia, hemiplegia, tinea alba.[extracts] " China's book on Chinese herbal medicine "

Cortex Machili Thunbergii Radicis: [source] medical material Ji Yuan: be root bark, the bark of the red nanmu of canella.[nature and flavor] are pungent; Bitter; Temperature.[return through] spleen; Liver; Stomach warp.[function cures mainly] warming middle-JIAO is pleasant; Shu Jing invigorates blood circulation; Reducing swelling and alleviating pain.Main vomiting and diarrhoea; Infantile milk regurgitation; Anorexia lack of appetite; Bruise; Convulsion; Foot is swollen.[each discussion] " will planted by Tianmu Mountains of Zhejiang Province medicine ": control bruise muscle, root or bark are mashed deposited with Sal; Control and vomit and diarrhoea incessantly, bark decocts water clothes; Control convulsion foot swollen, bark decocts soup fumigation and wash method.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae): [another name] Sarcococca ruscifolia Stapf, Rohdea japonica Roth, kwan-yin bavin, ferrum angle orchid, wooden Radix Polygalae.[source] medical material Ji Yuan: be the root of Buxaceae plant open country fan flower.[nature and flavor] are pungent; Bitter; Flat.[return through] liver; Stomach warp.[function cures mainly] promoting flow of QI and blood; Wind-expelling pain-stopping.Main gastralgia; Anemofrigid-damp arthralgia; Traumatic injury.[each discussion] 1. " Yunnan Chinese herbal medicine ": active, pain relieving.Treat for stomachache, traumatic injury.2. Jiangxi " medical herbs handbook ": relaxing muscles and tendons to promote blood circulation, detumescence of dispeling the wind.[extracts] " China's book on Chinese herbal medicine "

Radix Lamiophlomidis Rotatae: [another name] Ji Buzi, Mai Duochang bar, Ha Nubala, Ha Wuba draw, wild Radix Gentianae Macrophyllae.[source] medical material Ji Yuan: be root and rhizome or the herb of labiate Radix Lamiophlomidis Rotatae.[nature and flavor] sweet in the mouth; Bitter; Property is put down.[function cures mainly] blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain.Main traumatic injury; Bones and muscles pain; Arthralgia; Dysmenorrhea; Metrorrhagia.[each discussion] " Traditional Chinese Medicine in Sichuan will ": blood circulation promoting competent silt, pain relieving, circulation of qi promoting, detumescence, reunion of fractured tendons and bones.Control and get injured by a fall muscles and bones and diseases such as frustrating gas of spraining one's back.[extracts] " China's book on Chinese herbal medicine "

Caulis Seu Radix Kadsurae Oblongifoliae: [another name] Caulis Seu Radix Kadsurae Oblongifoliae, water oil lamp, thin Radix seu Caulis fici Martinii.[source] medical material Ji Yuan: be rattan or the root of the cold meal rattan of Schisandraceae Plant.[nature and flavor] are sweet; Warm in nature.[return through] lung; Stomach; Spleen; Intestinal; Kidney channel.[function cures mainly] expelling wind and removing dampness; Promoting the circulation of QI to relieve pain.Main flu; Rheumatic arthralgia; Heart peratodynia; Dysmenorrhea; Traumatic injury.[each discussion] " mountain of papers Chinese herbal medicine ": rattan: promoting the circulation of QI to relieve pain, expelling wind and removing dampness.Control gastroenteritis, flu, traumatic injury, rheumatalgia, fracture.[extracts] " China's book on Chinese herbal medicine "

Flos Citri grandis: [another name] Orange Blossom.[source] medical material Ji Yuan: be the flower of Citrus paradisi Macfadyen.[nature and flavor] are pungent; Bitter; Temperature.[return through] spleen; Stomach warp.[function cures mainly] circulation of qi promoting; Change and talk; Pain relieving.Pain between main gastral cavilty chest and diaphragm.[each discussion] 1. " conventional glossary of Herbs and Drugs among the people ": pleasant, pain relieving.2. " Guangxi Chinese medicinal herbal ": circulation of qi promoting, expectorant, analgesia.[extracts] " China's book on Chinese herbal medicine "

Herba Adenosmae Glutinosi: [another name] five cool grass, cool grass, bluet, Rhizoma et radix valerianae, Herba thymi vulgaris.[source] medical material Ji Yuan: be the herb of goatweed Herba Adenosmae Glutinosi.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] wind-damp dispelling; Detumescence poison; Qi and blood circulation promotion; Pain relieving is itched.Main rheumatic ostalgia; Poliomyelitis; Abdominal pain due to stagnation of QI; Furuncle toxic swelling; Skin eczema; Traumatic pain; Snake bite and insect sting.[each discussion] 1. " south of the Five Ridges gather medicinal herbs record ": reason traumatic injury wound, can reducing swelling and alleviating pain, and loose skin infection is vicious.Control pain due to disorder of QI.2. " Nanning City's medicine will ": hemostasis, pain relieving, dissipating blood stasis for subsidence of swelling.Control traumatic injury knife injury, rheumatism skin infection.3. Guangzhou army " conventional Chinese herbal medicine handbook ": wind-damp dispelling, detumescence pain.Control poliomyelitis, rheumatic ostalgia, wind and cold is suffered from abdominal pain, venom, traumatic injury, furuncle toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Radix Micromeli Integerrimi: [another name] Shan Yupi, Folium seu Radix Clausenae dentatae, wild tea are peppery, Pe1lionia tsoongii (Merr.) Merr..[source] medical material Ji Yuan: be the root of rutaceae Radix Micromeli Integerrimi, bark or leaf.[nature and flavor] bitter in the mouth, pungent; Warm in nature.[return through] stomach; Bladder; Lung meridian.[function cures mainly] dispelling wind to relieve the exterior syndrome; Warming middle-JIAO to promote flow of QI; Dissipating blood stasis for subsidence of swelling.Main flow sense; Cold cough; Stomachache; Rheumatic arthralgia; Treating swelling and pain by traumatic injury; Fracture.[each discussion] 1. " Guangxi Chinese herbal medicine ": circulation of qi promoting is eliminated the phlegm, expelling wind and removing dampness, eliminating stasis to stop pain.Cure cold cough, stomachache, rheumatic ostalgia.2. " choosing of Simao, Yunnan Chinese herbal medicine ": dispelling wind to relieve the exterior syndrome, warming middle-JIAO to promote flow of QI, detumescence dissipating blood stasis, hemostasis.Control influenza, malaria, traumatic injury, stomachache, rheumatic arthritis, traumatic hemorrhage, fracture.[extracts] " China's book on Chinese herbal medicine "

Radix et Caulis Opuntiae Dillenii: [another name] Feng Wei le, imperial tongue, kylin flower, inflammable hairpin.[source] medical material Ji Yuan: be root and the stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii and green Radix et Caulis Opuntiae Dillenii.[nature and flavor] are bitter; Cold in nature.[return through] heart; Lung; Stomach warp.[function cures mainly] promoting flow of QI and blood; Heat-clearing and toxic substances removing; Cooling blood for hemostasis; Clearing away lung-heat to relieve cough.Main stomachache; Mass in the abdomen; Dysentery; Laryngalgia; Cough due to lung-heat; Pulmonary tuberculosis is spat blood; Spit blood; Hemorrhoidal bleeding; Skin infection furuncle furuncle; Acute mastitis; To itch the cheek; Tinea disease; Snake bite and insect sting; Scald; Cold injury.[each discussion] be " Luchuan book on Chinese herbal medicine " 1.: eliminating inflammation and expelling toxin, evacuation of pus granulation promoting.Cure mainly carbuncle sore furuncle and phyma, cough.2. " Hunan medicine will ": reducing swelling and alleviating pain, promoting flow of QI and blood, damp eliminating is brought down a fever, granulation promoting.3. " east, Fujian book on Chinese herbal medicine ": energy blood stasis removing, intestinal detoxication, stomach invigorating, pain relieving, nourishing, relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis of curing the wound.Control hemorrhoidal hamorrhage anal fistula hematochezia, lung abscess, stomachache, traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Castaneae: [source] medical material Ji Yuan: be tree root or the root bark of Fagaceae Semen Castaneae.[nature and flavor] micro-hardship; Property is put down.[function cures mainly] promoting the circulation of QI to relieve pain; Promoting blood flow to regulate menstruation.The main hernia swelling and hanging down of either of the testes; Toothache; Rheumatic arthritis; Menoxenia.[each discussion] " Traditional Chinese Medicine in Sichuan will ": control arthralgia due to stagnation of blood.[extracts] " China's book on Chinese herbal medicine "

Flos Mume: [another name] Flos Pruni mume, FLOS MUME, flower bud of Japanese apricot.[source] medical material Ji Yuan: this product is the alabastrum of rosaceous plant FLOS MUME.[nature and flavor] bitter in the mouth, micro-sweet, micro-acid, cool in nature.[return through] returns liver, stomach, lung meridian.[function cures mainly] dispersing the stagnated live-QI to relieve the stagnation of QI, appetizing is promoted the production of body fluid, and reduces phlegm.Be mainly used to gloomy vexed; Stomachache due to hyperactive liver-QI attacking the stomach; Globus hystericus; Scrofula sore.[extracts] " China's book on Chinese herbal medicine "

Semen clausenae lansii: [another name] Clausena lansium (Lour.) Skeels core.[source] medical material Ji Yuan: be the seed of rutaceae Clausena lansium (Lour.) Skeels.[nature and flavor] acrid in the mouth; Micro-hardship; Tepor.[return through] lung; Stomach; Liver Channel.[function cures mainly] promoting the circulation of QI to relieve pain; Detoxicating and resolving stagnation of pathogens.Staple food indigestion pain; Stagnation of QI epigastric pain; Colic; Painful and swollen testis; Dysmenorrhea; Children's's head sore; Centipete bite.[each discussion] " Guangxi Chinese medicinal herbal ": circulation of qi promoting, disappears stagnant, eliminating stagnation.Control dyspepsia stomachache, painful and swollen testis.[extracts] " China's book on Chinese herbal medicine "

Herba Polygoni hydropiperis: [another name] knotweed, rose, willow knotweed, peppery willow herb, water Herba polygoni hydropiperis.[source] medical material Ji Yuan: be the aerial parts of polygonaceae plant Herba Polygoni hydropiperis.[nature and flavor] are pungent; Bitter; Property is put down.[return through] spleen; Stomach; Large intestine channel.The stagnant removing dampness of [function cures mainly] row; Dissipating blood stasis stops blooding; Dispelling wind for relieving itching; Removing toxic substances.Main humidity hysteresis internal resistance; The vexed stomachache of gastral cavity; Have loose bowels; Dysentery; Infantile malnutrition; Metrorrhagia; Amenorrhea due to stagnation of blood dysmenorrhea; Traumatic injury; Rheumatic arthralgia; Have blood in stool; Traumatic hemorrhage; Skin pruritus; Eczema; Rubella; Tinea pedis; Carbuncle; Venom.[each discussion] 1. " Zhiwu Mingshi Tukao ": control traumatic injury, logical muscles and bones.2. " Zhejiang conventional medical herbs among the people ": removing toxic substances, diuresis, circulation of qi promoting, dysentery relieving.[extracts] " China's book on Chinese herbal medicine "

Herba Physalis pubescentis: [another name] Zhi, Huang Zhi, Fructus Seu Herba Pubescentis, firecracker grass, Herba Crotalariae Ferrugineae.[source] medical material Ji Yuan: be the herb of plant of Solanaceae Herba Physalis pubescentis.[nature and flavor] bitter in the mouth; Acid; Cold in nature.[function cures mainly] heat clearing away; Diuresis; Removing toxic substances; Detumescence.Main flu; Cough due to lung-heat; Laryngopharynx swelling and pain; Gingival swelling and pain; Jaundice due to damp-heat; Dysentery; Edema; Pyretic stranguria; Pemphigus; Furuncle.[each discussion] " Chinese herbal medicine is commonly used in Shanghai ": heat-clearing and toxic substances removing, diuresis is stopped blooding, dispersing swelling and dissipating binds.Control laryngopharynx swelling and pain, lung abscess, parotitis; Dysuria, hematuria.Gingival swelling and pain, pemphigus.[extracts] " China's book on Chinese herbal medicine "

Herba Peperomiae Dindygulensis: [another name] burn leaf, peppergrass, Radix Ardisiae Punctatae, loose blood gallbladder.[source] medical material Ji Yuan: be the herb of Piperaceae plant Herba Peperomiae Dindygulensis.[nature and flavor] are pungent; Cool.[return through] lung; Spleen; Liver; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Inducing diuresis to remove edema.Main lung-heat cough with asthma; Measles; Sore; Cancerous protuberance; Burn and scald; Traumatic injury; Oedema due to nephritis.[each discussion] be " choosing of Yunnan Chinese herbal medicine " 1.: eliminating stasis and resolving masses, anticancer.Control gastric cancer, esophageal carcinoma, hepatocarcinoma, breast carcinoma, pulmonary carcinoma.2. " choosing of Simao, Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, detumescence dissipating blood stasis, pain relieving diuretic.Control traumatic injury, scald burn, carbuncle furuncle, oedema due to nephritis, pulmonary tuberculosis, asthma, tracheobronchitis, cough due to lung-heat.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Bistortae: [another name] Herba Salviae Chinensis, Rhizoma Paridis, copper sieve.[source] this product is the dry rhizome of polygonaceae plant Rhizoma Bistortae.[nature and flavor] are bitter, puckery, are slightly cold.[return through] returns lung, liver, large intestine channel.[function cures mainly] heat-clearing and toxic substances removing, detumescence, hemostasis.For bloody dysentery, diarrhea of heat type, cough due to lung-heat, carbuncle, scrofula, aphtha of the mouth and tongue, spits blood, epistaxis, bleeding hemorrhoids, venom.[extracts] " Chinese Pharmacopoeia "

Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis): [another name] Xun thorn wood, the stupefied son of rock, Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) root.[source] medical material Ji Yuan: be branch and leaf or the root of rosaceous plant Cotoneaster horizontalis.[nature and flavor] are sour, puckery; Cool.[return through] lung; Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis, preventing phlegm from forming and stopping coughing, hemostasis and pain-relieving.Main dysentery, has loose bowels, stomachache, and cough is spitted blood, dysmenorrhea, leucorrhea.[each discussion] 1. " mount emei medicine is planted ": cough-relieving, decoct water clothes.[extracts] " China's book on Chinese herbal medicine "

When the dosage form of described Chinese medicine preparation is tablet, it comprises the following steps:

When the dosage form of described Chinese medicine preparation is capsule, it comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1: tablet prepared by the present invention

Get geaster 120g, Eucheuma gelatinosum 250g, Pheropsophus jessoensis Mor. 310g, Radix Salicis Hypoleucae 190g, Semen Bauhiniae championii 210g, Cortex Ulmi virgatae 350g, purslane speedwell Herba 160g, Huechys sanguinea De Geer. 280g, Herba Lycopodii Obscuri 310g, Radix Buddlejae Butterflybush 100g, Lycopodium casuarinoides Spring 260g, Rhizoma Polypodiodis Nipponicae 150g, Cortex Machili Thunbergii Radicis 210g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 350g, Radix Lamiophlomidis Rotatae 160g, Caulis Seu Radix Kadsurae Oblongifoliae 290g, Flos Citri grandis 320g, Herba Adenosmae Glutinosi 100g, Radix Micromeli Integerrimi 170g, Radix et Caulis Opuntiae Dillenii 250g, Radix Castaneae 260g, Flos Mume 100g, Semen clausenae lansii 260g, Herba Polygoni hydropiperis 150g, Herba Physalis pubescentis 210g, Herba Peperomiae Dindygulensis 350g, Rhizoma Bistortae 120g and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 190g.

The first step, geaster, Eucheuma gelatinosum, Pheropsophus jessoensis Mor., Radix Salicis Hypoleucae, Semen Bauhiniae championii, Cortex Ulmi virgatae, purslane speedwell Herba, Huechys sanguinea De Geer., Herba Lycopodii Obscuri, Radix Buddlejae Butterflybush, Lycopodium casuarinoides Spring, Rhizoma Polypodiodis Nipponicae, Cortex Machili Thunbergii Radicis, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Radix Lamiophlomidis Rotatae and Caulis Seu Radix Kadsurae Oblongifoliae are mixed in proportion, add relative to mixture 8 times amount determining alcohol be 80% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 6 times of water gagings, boils 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.29;

3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, carries out mixing by described dried cream powder and starch and processes, obtain mastic mixture; Described mastic and the weight ratio of starch are 1: 0.015; Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained;

5th step, described mastic compound particles and Pulvis Talci, magnesium stearate are carried out successively mixing processes, tabletting process, Cotton seeds, obtain Chinese medicine preparation tablet finished product; The weight ratio of described granule, Pulvis Talci, magnesium stearate is 100: 1.8: 0.22.

Embodiment 2: capsule prepared by the present invention

Get geaster 150g, Eucheuma gelatinosum 210g, Pheropsophus jessoensis Mor. 350g, Radix Salicis Hypoleucae 160g, Semen Bauhiniae championii 250g, Cortex Ulmi virgatae 320g, purslane speedwell Herba 190g, Huechys sanguinea De Geer. 260g, Herba Lycopodii Obscuri 350g, Radix Buddlejae Butterflybush 70g, Lycopodium casuarinoides Spring 280g, Rhizoma Polypodiodis Nipponicae 120g, Cortex Machili Thunbergii Radicis 250g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 310g, Radix Lamiophlomidis Rotatae 190g, Caulis Seu Radix Kadsurae Oblongifoliae 260g, Flos Citri grandis 350g, Herba Adenosmae Glutinosi 70g, Radix Micromeli Integerrimi 190g, Radix et Caulis Opuntiae Dillenii 210g, Radix Castaneae 280g, Flos Mume 70g, Semen clausenae lansii 290g, Herba Polygoni hydropiperis 120g, Herba Physalis pubescentis 250g, Herba Peperomiae Dindygulensis 310g, Rhizoma Bistortae 150g and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 170g.

Its preparation method comprises the following steps:

The first step, geaster, Eucheuma gelatinosum, Pheropsophus jessoensis Mor., Radix Salicis Hypoleucae, Semen Bauhiniae championii, Cortex Ulmi virgatae, purslane speedwell Herba, Huechys sanguinea De Geer., Herba Lycopodii Obscuri and Radix Buddlejae Butterflybush are mixed in described ratio, add the water extraction volatile oil relative to 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 5, stirs 85 minutes, temperature 50 C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.17;

Second step, Lycopodium casuarinoides Spring, Rhizoma Polypodiodis Nipponicae, Cortex Machili Thunbergii Radicis, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Radix Lamiophlomidis Rotatae, Caulis Seu Radix Kadsurae Oblongifoliae, Flos Citri grandis, Herba Adenosmae Glutinosi, Radix Micromeli Integerrimi and Radix et Caulis Opuntiae Dillenii are mixed in described ratio, add relative to mixture 8 times amount determining alcohol be 90% alcohol reflux 5 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.21, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 7 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 70 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 8 weight portion carboxymethyl starch sodium, 35 weight starch mix homogeneously, adding 190 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 5 weight portion magnesium stearate, then load in gelatine capsule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 26-38g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.65g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.25 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>43.25 crude drug/kg of the present invention, every day, maximum dosage-feeding was 86.5 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.25g crude drug/day/people, adult body weight in 60KG, average dosage is 0.1375g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 32g) oral administration gavage Chinese medicine of the present invention is 629 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 13.25,25.41 and 42.37g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: the costal chondritis patient that all 165 routine cases all derive from this Out-patient Department and are in hospital.It is divided into treatment group and matched group at random.Wherein, in the routine patient for the treatment of group 83, man 25 example, female 58 example; 18 ~ 56 years old age; The course of disease 2 weeks ~ 2 years.In the routine patient of matched group 82, man 23 example, female 59 example; 18 ~ 58 years old age; The course of disease 2 weeks ~ 1 year 9 months.Treatment group and matched group be no significant difference (P≤0.01) in sex, age, the course of disease and clinical symptoms, has comparability.

Western medicine diagnose standard: 1, affected part pain and costicartilage swelling, acute stage pain often with breathing, cough, upper limb is movable and aggravate, minority is with low grade fever.2, local skin there is no inflammatory reaction, but the rib of enlargement can continue to several months or several years.3, x-ray rabat is there are no any feature, or local soft tissue swelling and bone destruction as seen.4, CT examination finds diseased region soft tissue swelling, and costicartilage destroys and hydrops, subperiosteum empyema under muscle layer.5, lab testing: ESR, ASO and RF are generally all in normal range.6, the optimum or malignant tumor of thoracic tuberculosis, osteomyelitis of rib, costicartilage and Other diseases is got rid of.

Therapeutic Method:

Matched group: 0.5% lignocaine 2mL is dissolved in hydrocortisone acetate 25mg, local block therapy is carried out to patient, 1 time/week; Within 1 week, be a course for the treatment of, treat 3 courses for the treatment of, follow up a case by regular visits to 9 months statistics therapeutic outcomes.

Treatment group: on the basis for the treatment of group, simultaneously oral Chinese medicine embodiment 1 tablet of the present invention, each 3, every day 3 times; Within 1 week, be a course for the treatment of, treat 3 courses for the treatment of, follow up a case by regular visits to 9 months statistics therapeutic outcomes.

Curative effect judging standard: (1) cures: local swelling is disappeared completely, pain disappears, and drug withdrawal has no recurrence above later six months.(2) effective: local swelling is obviously gone down, pain is obviously alleviated.(3) effective: local swelling is alleviated to some extent, and pain alleviates to some extent.(4) invalid: swelling and pain unchanged or increase the weight of.

Therapeutic outcome: two groups treat 3 weeks respectively after, statistical result is see table 1.

Table 1 liang group treats Clinical efficacy comparison after 3 weeks (unit: example) respectively

Group	Number of cases	Cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	83	42	21	17	3	80(96.39％)
Matched group	82	31	23	11	17	65(79.27％)

As can be seen from Table 1, treatment group adopts Chinese medicine of the present invention, coordinates western medical treatment costal chondritis, relative to matched group, on therapeutic effect, has significant improvement.

Untoward reaction: treatment group and matched group all without anaphylaxis, without Liver and kidney function damage, also other untoward reaction of aspect such as apnea system, digestive system, hemopoietic system and nervous system

Concrete case: Zhao, female, 31 years old, patient's chest pain recurrent exerbation half a year, meet cold pain to increase the weight of, night can not fall asleep, and health check-up finds that parasternal second costal cartilage joint has obvious tumefaction, there are tenderness, skin sensitivity, without red heat, check that clinical diagnosis is costal chondritis in conjunction with x-ray rabat etc.0.5% lignocaine 2mL is dissolved in hydrocortisone acetate 25mg, local block therapy is carried out to patient, 1 time/week; The tablet of oral inventive embodiments 1 simultaneously, each 3, every day 3 times.Take 3 weeks, local swelling is disappeared completely, and pain disappears, and follows up a case by regular visits to 9 months without recurrence, cures.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat the Chinese medicine preparation of costal chondritis for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: geaster, Eucheuma gelatinosum, Pheropsophus jessoensis Mor., Radix Salicis Hypoleucae, Semen Bauhiniae championii, Cortex Ulmi virgatae, purslane speedwell Herba, Huechys sanguinea De Geer., Herba Lycopodii Obscuri, Radix Buddlejae Butterflybush, Lycopodium casuarinoides Spring, Rhizoma Polypodiodis Nipponicae, Cortex Machili Thunbergii Radicis, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Radix Lamiophlomidis Rotatae, Caulis Seu Radix Kadsurae Oblongifoliae, Flos Citri grandis, Herba Adenosmae Glutinosi, Radix Micromeli Integerrimi, Radix et Caulis Opuntiae Dillenii, Radix Castaneae, Flos Mume, Semen clausenae lansii, Herba Polygoni hydropiperis, Herba Physalis pubescentis, Herba Peperomiae Dindygulensis, Rhizoma Bistortae and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis).

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: geaster 5 ~ 15 parts, Eucheuma gelatinosum 15 ~ 25 parts, Pheropsophus jessoensis Mor. 25 ~ 35 parts, Radix Salicis Hypoleucae 10 ~ 20 parts, Semen Bauhiniae championii 15 ~ 30 parts, Cortex Ulmi virgatae 30 ~ 40 parts, purslane speedwell Herba 15 ~ 25 parts, Huechys sanguinea De Geer. 15 ~ 30 parts, Herba Lycopodii Obscuri 25 ~ 35 parts, Radix Buddlejae Butterflybush 5 ~ 15 parts, Lycopodium casuarinoides Spring 25 ~ 35 parts, Rhizoma Polypodiodis Nipponicae 10 ~ 20 parts, Cortex Machili Thunbergii Radicis 15 ~ 25 parts, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 30 ~ 40 parts, Radix Lamiophlomidis Rotatae 10 ~ 25 parts, Caulis Seu Radix Kadsurae Oblongifoliae 20 ~ 30 parts, Flos Citri grandis 25 ~ 35 parts, Herba Adenosmae Glutinosi 5 ~ 15 parts, Radix Micromeli Integerrimi 10 ~ 20 parts, Radix et Caulis Opuntiae Dillenii 15 ~ 25 parts, Radix Castaneae 20 ~ 30 parts, 5 ~ 15 parts, Flos Mume, Semen clausenae lansii 25 ~ 35 parts, Herba Polygoni hydropiperis 10 ~ 20 parts, Herba Physalis pubescentis 15 ~ 25 parts, Herba Peperomiae Dindygulensis 30 ~ 40 parts, Rhizoma Bistortae 5 ~ 15 parts and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 15 ~ 30 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: geaster 10 ~ 15 parts, Eucheuma gelatinosum 20 ~ 25 parts, Pheropsophus jessoensis Mor. 30 ~ 35 parts, Radix Salicis Hypoleucae 15 ~ 20 parts, Semen Bauhiniae championii 20 ~ 25 parts, Cortex Ulmi virgatae 30 ~ 35 parts, purslane speedwell Herba 15 ~ 20 parts, Huechys sanguinea De Geer. 25 ~ 30 parts, Herba Lycopodii Obscuri 30 ~ 35 parts, Radix Buddlejae Butterflybush 5 ~ 10 parts, Lycopodium casuarinoides Spring 25 ~ 30 parts, Rhizoma Polypodiodis Nipponicae 10 ~ 15 parts, Cortex Machili Thunbergii Radicis 20 ~ 25 parts, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 30 ~ 35 parts, Radix Lamiophlomidis Rotatae 15 ~ 20 parts, Caulis Seu Radix Kadsurae Oblongifoliae 25 ~ 30 parts, Flos Citri grandis 30 ~ 35 parts, Herba Adenosmae Glutinosi 5 ~ 10 parts, Radix Micromeli Integerrimi 15 ~ 20 parts, Radix et Caulis Opuntiae Dillenii 20 ~ 25 parts, Radix Castaneae 25 ~ 30 parts, 5 ~ 10 parts, Flos Mume, Semen clausenae lansii 25 ~ 30 parts, Herba Polygoni hydropiperis 10 ~ 15 parts, Herba Physalis pubescentis 20 ~ 25 parts, Herba Peperomiae Dindygulensis 30 ~ 35 parts, Rhizoma Bistortae 10 ~ 15 parts and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 15 ~ 20 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: geaster 12 parts, Eucheuma gelatinosum 25 parts, Pheropsophus jessoensis Mor. 31 parts, Radix Salicis Hypoleucae 19 parts, Semen Bauhiniae championii 21 parts, Cortex Ulmi virgatae 35 parts, purslane speedwell Herba 16 parts, Huechys sanguinea De Geer. 28 parts, Herba Lycopodii Obscuri 31 parts, Radix Buddlejae Butterflybush 10 parts, Lycopodium casuarinoides Spring 26 parts, Rhizoma Polypodiodis Nipponicae 15 parts, Cortex Machili Thunbergii Radicis 21 parts, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 35 parts, Radix Lamiophlomidis Rotatae 16 parts, Caulis Seu Radix Kadsurae Oblongifoliae 29 parts, Flos Citri grandis 32 parts, Herba Adenosmae Glutinosi 10 parts, Radix Micromeli Integerrimi 17 parts, Radix et Caulis Opuntiae Dillenii 25 parts, Radix Castaneae 26 parts, 10 parts, Flos Mume, Semen clausenae lansii 26 parts, Herba Polygoni hydropiperis 15 parts, Herba Physalis pubescentis 21 parts, Herba Peperomiae Dindygulensis 35 parts, Rhizoma Bistortae 12 parts and Ramulus et Folium Cotoneastri Horizontalis (Radix Cotoneastri horizontalis) 19 parts.

5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:

6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and it comprises the following steps:

8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps: