CN103860844B - A kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof - Google Patents

A kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof Download PDF

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CN103860844B
CN103860844B CN201410124716.2A CN201410124716A CN103860844B CN 103860844 B CN103860844 B CN 103860844B CN 201410124716 A CN201410124716 A CN 201410124716A CN 103860844 B CN103860844 B CN 103860844B
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rhizoma
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袁志贤
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袁志贤
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system

Abstract

The invention discloses a kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof, invention formulation is by Cortex Magnoliae Officinalis, Poria, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, thief's bone, the Rhizoma Pinelliae, Rhizoma Corydalis, the Radix Rehmanniae and Fructus Jujubae are through pulverizing, decoct, the compositions liquid formulation that the operation such as ethanol extraction and mixing is prepared into, the present invention treats chronic colitis successful, by the compositions that the above-mentioned drug matching of the present invention and preparation method obtain, dialectical method is adopted effectively to reach effect of conditioning intestinal and the vital organs of the human body, have no side effect, effect stability, the curative effect of getting twice the result with half the effort is reached compared with Western medicine.

Description

A kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of colitis, be specifically related to a kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof.
Background technology
Intestinal refers to the digestive tube from stomach pylorus to anus, and intestinal is one section the longest in digestive tube, is also most important one section of function.Intestinal is the maximum digestive organs of human body, is also the maximum toxin expelling organ of human body.From physiology, anatomy, cytological angle, large intestine toxin expelling accounts for more than 85% of human detoxification; 80% immune structure of human body is around intestinal, and endotoxic accumulation is the killer of autoimmunity.
Chronic colitis is a kind of common disease, clinically shows as that times of defecation increases, five indigested foods or as water sample or viscid, with borborygmus, stomachache, notably spleen kidney is all empty, lets out just before dawn more.The internal organs such as spleen, stomach, liver, kidney at intestinal, but are involved in general sick position, with the passing of time then become thin, asthenia.This card is one of clinical common the spleen-stomach disease, and sickness rate is high, easy recurrent exerbation, and touching difficulty more, drastically influence the orthobiosis of people, and with the passing of time canceration rate reaches about 5%.Although the medicine being used for the treatment of colitis is at present not very few, Western medicine is cured the symptoms, not the disease, and used of a specified duration and easily developed immunity to drugs, side effect is larger, infringement liver, kidney and hemocyte, and drug effect is unstable, easy recurrent exerbation.
Summary of the invention
Namely object of the present invention is for above-mentioned deficiency, on the basis of secret prescription handed down in the family from generation to generation, in conjunction with modern Chinese and western medicine technology, there is provided a kind of Chinese medicine preparation for the treatment of chronic colitis, be to provide this Chinese medicine preparation and preparation method thereof specifically, colitis therapeutic effect of the present invention is obvious, and it is nontoxic, have no side effect, effect stability, reparation technology is simple and easy to do.
Technical scheme of the present invention is as described below:
Invention formulation is the composite preparation be prepared into by Cortex Magnoliae Officinalis, Poria, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Rhizoma Pinelliae, Rhizoma Corydalis, the Radix Rehmanniae and Fructus Jujubae, and wherein the quality proportioning of each component is:
Cortex Magnoliae Officinalis 12-20g Poria 10-22g Fructus Evodiae 8-18g
Radix Astragali 10-18g Radix Glycyrrhizae 8-15g Radix Notoginseng 10-20g
Radix Et Rhizoma Rhei 8-16g Radix Paeoniae Alba 12-20g Fructus Citri Sarcodactylis 8-16g
Rhizoma Dioscoreae 10-18g Fructus Toosendan 10-18g Lignum Dalbergiae Odoriferae 10-18g
Rhizoma Anemones Altaicae 8-15g Radix Asparagi 6-15g thief bone 8-15g
Rhizoma Pinelliae 10-18g Rhizoma Corydalis 8-16g Radix Rehmanniae 8-15g
Fructus Jujubae 10-20g.
In order to obtain better effect, the present invention can raw material mass mixture ratio be preferably:
Cortex Magnoliae Officinalis 12-18g Poria 10-18g Fructus Evodiae 8-12g
Radix Astragali 12-18g Radix Glycyrrhizae 8-12g Radix Notoginseng 10-15g
Radix Et Rhizoma Rhei 8-12g Radix Paeoniae Alba 12-16g Fructus Citri Sarcodactylis 8-12g
Rhizoma Dioscoreae 10-15g Fructus Toosendan 10-14g Lignum Dalbergiae Odoriferae 10-15g
Rhizoma Anemones Altaicae 8-12g Radix Asparagi 6-10g thief bone 8-12g
Rhizoma Pinelliae 10-15g Rhizoma Corydalis 8-12g Radix Rehmanniae 8-12g
Fructus Jujubae 12-18g.
Certainly, in order to obtain effect good further, the present invention can raw material mass mixture ratio be preferably also:
Cortex Magnoliae Officinalis 15g Poria 12g Fructus Evodiae 9g
Radix Astragali 15g Radix Glycyrrhizae 10g Radix Notoginseng 12g
Radix Et Rhizoma Rhei 12g Radix Paeoniae Alba 10g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 12g Fructus Toosendan 14g Lignum Dalbergiae Odoriferae 12g
Rhizoma Anemones Altaicae 8g Radix Asparagi 8g thief bone 12g
Rhizoma Pinelliae 10g Rhizoma Corydalis 8g Radix Rehmanniae 10g
Fructus Jujubae 15g.
The preparation method of above-mentioned treatment chronic colitis Chinese medicine preparation, comprises the steps:
1), by Poria put into pannikin and carry out stir-fry dish cooked in a small wok, meaning the food is prepared with special care to surperficial micro-Jiao, then pulverize through pulverizer and cross 80 mesh sieves, for subsequent use;
2), by Cortex Magnoliae Officinalis, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Fructus Jujubae, the Rhizoma Pinelliae, Rhizoma Corydalis prepare in proportion, be ground into powder through pulverizer and cross 90 mesh sieves, naturally drying, for subsequent use;
3), by step 1) and 2) in each component powders mix, add pure water and decoct twice, first time adds 10 times of pure water and decocts 1 hour, and it is for subsequent use to extract filtrate; Second time adds 6 times of pure water and decocts half an hour, then collecting decoction filtering, for subsequent use;
4) Radix Notoginseng, by remaining, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Radix Rehmanniae prepare in proportion, are ground into powder and cross 80 mesh sieves, naturally dry through pulverizer, for subsequent use;
5), by component powders each in step 4) mix, add the ethanol of 4 ~ 6 times 70% ~ 80%, reflux 3 ~ 5 hours, extract and filter acquisition filtrate; Then in remaining medicinal residues, again add the ethanol of 2 ~ 4 times 65% ~ 75%, reflux 2 ~ 3 hours, extract and filter acquisition filtrate; The filtrate of twice acquisition is combined, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
6), by above-mentioned steps 5) in the dry cream that obtains carry out micronizing powdered and cross 200 mesh sieves, then powder is added 3) collecting decoction in step, mixing shakes up and can obtain.
The above-mentioned Chinese medicine composition pharmaceutical solutions produced may be used for oral, if can the morning, noon and afternoon respectively drink once and long-term drink in right amount, and better effects if.
Theoretical foundation of the present invention is:
Cortex Magnoliae Officinalis, be a kind of medicinal plants belonging to Magnoliaceae, growth district is mainly on the ground such as Sichuan, Hubei.Cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant stops up QI rising in reverse order, and fullness in the chest such as to be breathed with cough at the symptom.Have removing dampness intestinal stasis relieving, circulation of qi promoting relievingd asthma, relieving dyspepsia expectorant, wind dispelling analgesia effect; Cortex Magnoliae Officinalis is reflexive causes saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and has the digestant effect of stomach invigorating; Cortex Magnoliae Officinalis decoct has broad-spectrum antibacterial action, and external all have inhibitory action to staphylococcus aureus, Hemolytic streptococcus, diphtheria corynebacterium etc.; In addition, Cortex Magnoliae Officinalis regulates the effect such as smooth muscle, antiulcer, CNS inhibition, blood pressure lowering, resisting pathogenic microbes, antitumor in addition.
Poria, sweet in the mouth, light, property is put down, be used as medicine and there is the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Fructus Evodiae, nature and flavor heat, taste is bitter, pungent, and " herbal classic " records Fructus Evodiae: " main warming the middle warmer and descending qi, pain relieving, cough with dyspnea cold and heat, dehumidifying, arthralgia due to stagnation of blood, by ailment said due to cold or exposure, loosing the interspaces of skin and muscles." Compendium of Material Medica record Fructus Evodiae: " dissipating depression of QIization is stagnant, controls acid regurgitation, and cloudy sputum of fainting is had a headache, insidious stomachache, hernia dysentery, mouthpiece's aphtha." there is the merit of dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, be used for the treatment of that liver insufficiency of stomach is trembled with fear, the disease such as headache or gastralgia caused by cloudy turbid superinverse.
The effects such as the Radix Astragali, has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, detoxification granulation promoting.Cure mainly the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back.
Radix Glycyrrhizae, be a kind of tonification Chinese herbal medicine, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong etc.
Radix Notoginseng, for the dissipating blood stasis that stops blooding, subduing swelling and relieving pain.Cure mainly haematemesis, hemoptysis, hematuria, have blood in stool, dysentery, metrorrhagia, postpartum hemorrhage, traumatic hemorrhage, injury from falling down, obstruction of qi in the chest and cardialgia, gastral cavity is coerced Tong , mass in the abdomen of a specified duration and is amassed block, blood stasis amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, sore, carbuncle and painful swelling; With other drug matchings of the present invention, treatment colitis successful.
Radix Et Rhizoma Rhei, bitter in the mouth, cold in nature, return stomach, spleen, large intestine, liver, pericardium channel, can purging heat and dredging bowels, eliminating blood stasis and inducing menstruation, removing pathogenic heat from blood and toxic substance from the body.For blood stasis amenorrhea, traumatic injury, jaundice due to damp-heat, heat in blood tells nosebleed, excess-heat constipation, stagnant stomachache, abdominalgia with intestinal abscess, and dysentery is not well, conjunctival congestion, pharyngeal swelling, carbuncle furuncle, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.There is stasis of blood bleeder for heat in blood, cure mainly acute taste-blindness rate and merge hemorrhage.
The Radix Paeoniae Alba, bitter in the mouth, acid, is slightly cold, returns Liver Channel.Nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, stimulates the menstrual flow, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, and dysentery is had loose bowels, and has a headache dizzy.
Fructus Citri Sarcodactylis, bitter in the mouth, pungent, sweet, warm in nature, nontoxic, enter liver, spleen, stomach three warp, have depressed liver-energy dispersing and QI regulating, and effect of gastrointestinal pain relieving, for stagnation of liver-QI and stomach-QI, gastral cavilty feeling of fullness, lack of appetite is vomitted, and has obvious inhibitory action, have spasmolysis to enterospasm to intestinal tube smooth muscle; There is expansion hat Like blood vessel, increase the effect of coronary flow; Can myocardial contraction be weakened during high concentration, decreased heart rate, reduce blood pressure, with Ischemic myocardium; There is certain phlegm-dispelling functions.
Rhizoma Dioscoreae, sweet in the mouth, profit cool in nature, enters lung, spleen, kidney channel, containing the material such as amylase, polyphenol oxidase, is conducive to taste digestive and absorptive functions, is the product of the medicine-food two-purpose of flat tonifying the spleen and stomach simply.No matter spleen sun loses or deficiency of stomach-YIN, all edible.Often clinically drink together that weakness of the spleen and stomach, lack of appetite body are tired, the disease such as to have loose bowels with controlling with gastrointestinal.Spleen reinforcing, supports lung, reinforces the kidney, benefit essence; Cure mainly diarrhea due to hypofunction of the spleen, lack of appetite edema, cough and asthma due to lung deficiency, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition of suffering from a deficiency of the kidney.
Fructus Toosendan, nature and flavor are bitter, cold; Slightly poisonous, return liver, small intestinal, urinary bladder channel.Soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Lignum Dalbergiae Odoriferae, property is pungent, warm, returns liver, spleen channel.Promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage; And the vomiting stomachache of colic of cold type pain or foul internal resistance.
Rhizoma Anemones Altaicae, nature and flavor are pungent, tepor, nontoxic; GUIXIN, liver, spleen channel, have waking up the patient from unconsciousness by dissipating phlegm, calms the nerves, and a surname is wet to be amusing, effect of removing toxic substances; Main calentura coma, epilepsy, deafness with qi stagnation, dreaminess is forgetful, abdominal distention uncomfortable in chest, inappetence, rheumatic arthralgia, carbuncle, the diseases such as scabies.
Radix Asparagi, nature and flavor: sweet, bitter, cold; Return lung, kidney channel.Quench one's thirst for fever due to yin deficiency, dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat, dryness of the intestine constipation, consumptive lung disease, lung abscess, the symptom such as diphtheria; Have inhibitory action to various bacteria, have anti-tumor activity, energy YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire, except dry pathogenic fire reducing.
Os Sepiae, containing calcium carbonate, can in and gastric acid, alleviate acid regurgitation and heartburn symptom, can promote that again ulcer surface inflammation absorbs, and stops hemorrhage, alleviate local pain. therefore can antacid be made. experiment shows: its compound preparation Medicinal powder of cuttlefish and firtillary bulb have obvious absorption pepsin and in and the effect of gastric acid, the stimulation of gastric acid to gastric ulcer face can be reduced, also reduce protease to the Digestion of ulcer surface, be conducive to the intestines and stomach with this.
The Rhizoma Pinelliae, nature and flavor are pungent, temperature, poisonous.Return spleen, stomach, lung meridian.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effects such as dissolving lump and resolving mass; Cure mainly cough with asthma abundant expectoration, vomiting regurgitation, feeling of oppression and fullness in the chest and epigastrium, the diseases such as dizzy, uneasy sleeping at night, gall subcutaneous nodule, swollen ulcer drug of having a headache.
Rhizoma Corydalis, warm in nature, acrid in the mouth, hardship, return liver, spleen, stomach warp, be the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, be especially world-famous for effect of pain relieving.Cure mainly the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
The Radix Rehmanniae, sweet in the mouth, hardship, cold in nature; GUIXIN, liver, lung meridian.Heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, be usually used in the diseases such as treatment hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.With other drug matchings of the present invention, evident in efficacy.
Fructus Jujubae, Fructus Jujubae sweet in the mouth warm in nature, containing protein, fat, sugar, calcium, phosphorus, ferrum, magnesium and abundant vitamin, in addition containing carotene etc., nutrition is very abundant, has spleen reinforcing, nourishes blood, sedative action, tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, the function of loosening bowel to relieve constipation, has the effect that lung moistening spleen invigorating, cough-relieving, tonifying five ZANG-organs, treatment are deficient.
From China's Traditional Chinese Medicine angle, the differential diagnosis of diseases of the chronic colitis traditional Chinese medical science belongs to the category such as " having loose bowels ", " Hakuri ".Clinical symptoms is with chronic diarrhea, stomachache, row's mucus just, hemafecia is main, in chronic repeatability outbreak or persistence outbreak, the primary disease course of disease is longer, how because chronic dietary is careless, overstrain internal injury, cause weakness of the spleen and stomach, therefore by the compositions that the above-mentioned drug matching of the present invention and preparation method obtain, adopt dialectical method effectively to reach effect of conditioning intestinal and the vital organs of the human body, have no side effect, effect stability, reaches the curative effect of getting twice the result with half the effort compared with Western medicine.
clinical experiment 1:
1), observing time: when technical solution of the present invention does not disclose, select in April, 2011 by 6 months of in JIUYUE, 2011.
2), the object of observation: select 10 routine chronic colitis cases in Shenzhen City, Guangdong Province Gastroenterology dept. of institute of traditional Chinese medicine: man 5 example, female 5 example; Age: 41-55 years old 5 example, 62-75 years old 5 example; Occupation: common working clan 5 example, retired person 5 example.Disease: stomachache, the abdominal distention of recurrent exerbation, suffer from diarrhoea, rush down lower mucus or bloody purulent stool, stage of attack, defecates more than 3 times/day, the smooth or tenesmus of companion's defecation; The many Huangs of tongue fur are greasy or greasy in vain; Whole disease is just all made a definite diagnosis through intestinal fiberscopy.
3), using method: taken half an hour after the meal by invention formulation oral liquid, every day 3 times, each 200ml, 2 months be 1 course for the treatment of, 3 courses for the treatment of are as observation of curative effect.
4), observing effect:
After taking 3 courses for the treatment of continuously, clinical symptoms, sign disappear, intestinal fiberscope check is normal, and intestinal mucosa pathological changes recovers normal 4 examples, and clinical symptoms obviously alleviates, sign disappears substantially, intestinal fiberscope check takes a turn for the better, 4 examples that intestinal mucosa pathological changes is obviously improved, and before and after treatment, clinical symptoms and sign are without improvement, intestinal fiberscope check is routine without take a turn for the better 2, total effective rate 80%.
clinical experiment 2 :
1), observing time: when technical solution of the present invention does not disclose, select 6 months of in February, 2011 in July, 2011.
2), the object of observation: 20 routine cases are selected by Gastroenterology dept. of institute of traditional Chinese medicine in Futian District, Shenzhen City, Guangdong Province: man 10 example, female 10 example; Age: 33-55 years old 10 example, 58-75 years old 10 example; Occupation: once assumed the leadership post civil servant 10 example, common teachers 10 example.Disease: stomachache, the abdominal distention of recurrent exerbation, suffer from diarrhoea, rush down lower mucus or bloody purulent stool, stage of attack, defecates more than 3 times/day, the smooth or tenesmus of companion's defecation; The many Huangs of tongue fur are greasy or greasy in vain; Whole disease is just all made a definite diagnosis through intestinal fiberscopy.
3), using method: taken half an hour after the meal by invention formulation oral liquid, every day 3 times, each 200ml, 2 months be 1 course for the treatment of, 3 courses for the treatment of are as observation of curative effect.
4), observing effect:
After taking 3 courses for the treatment of continuously, clinical symptoms, sign disappear, intestinal fiberscope check is normal, and intestinal mucosa pathological changes recovers normal 10 examples, and clinical symptoms obviously alleviates, sign disappears substantially, intestinal fiberscope check takes a turn for the better, 5 examples that intestinal mucosa pathological changes is obviously improved, and before and after treatment, clinical symptoms and sign are without improvement, intestinal fiberscope check is routine without take a turn for the better 5, total effective rate 75%.
clinical experiment 3 :
1), observing time: when technical solution of the present invention does not disclose, select 6 months of in June, 2013 in November, 2013.
2), the object of observation: select 30 routine cases in Gastroenterology dept. of Song Gang the People's Hospital, Shenzhen City, Guangdong Province: man 14 example, female 16 example; Age: 35-55 years old 16 example, 60-75 years old 14 example; Occupation: common private enterprise master 14 example, common retired professor 16 example.Disease: stomachache, the abdominal distention of recurrent exerbation, suffer from diarrhoea, rush down lower mucus or bloody purulent stool, stage of attack, defecates more than 3 times/day, the smooth or tenesmus of companion's defecation; The many Huangs of tongue fur are greasy or greasy in vain; Whole disease is just all made a definite diagnosis through intestinal fiberscopy.
3), using method: taken half an hour after the meal by invention formulation oral liquid, every day 3 times, each 200ml, 2 months be 1 course for the treatment of, 3 courses for the treatment of are as observation of curative effect.
4), observing effect:
After taking 3 courses for the treatment of continuously, clinical symptoms, sign disappear, intestinal fiberscope check is normal, and intestinal mucosa pathological changes recovers normal 20 examples, and clinical symptoms obviously alleviates, sign disappears substantially, intestinal fiberscope check takes a turn for the better, 5 examples that intestinal mucosa pathological changes is obviously improved, and before and after treatment, clinical symptoms and sign are without improvement, intestinal fiberscope check is routine without take a turn for the better 5, total effective rate 84%.
In conjunction with above clinical data and theoretical foundation of the present invention, visible beneficial effect of the present invention is, the preparation that the present invention makes, and has good result for treatment chronic colitis, and nontoxic, and have no side effect, effect stability, reparation technology is simple and easy to do.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is explained detailedly:
embodiment 1:
Invention formulation is the composite preparation be prepared into by Cortex Magnoliae Officinalis, Poria, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Rhizoma Pinelliae, Rhizoma Corydalis, the Radix Rehmanniae and Fructus Jujubae, and wherein the quality proportioning of each component is:
Cortex Magnoliae Officinalis 12g Poria 10g Fructus Evodiae 10g
Radix Astragali 12g Radix Glycyrrhizae 12g Radix Notoginseng 15g
Radix Et Rhizoma Rhei 10g Radix Paeoniae Alba 12g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 15g Fructus Toosendan 15g Lignum Dalbergiae Odoriferae 13g
Rhizoma Anemones Altaicae 12g Radix Asparagi 8g thief bone 10g
Rhizoma Pinelliae 12g Rhizoma Corydalis 13g Radix Rehmanniae 10g
Fructus Jujubae 16g.
The preparation method of above-mentioned treatment chronic colitis Chinese medicine preparation, comprises the steps:
1), by Poria put into pannikin and carry out stir-fry dish cooked in a small wok, meaning the food is prepared with special care to surperficial micro-Jiao, then pulverize through pulverizer and cross 80 mesh sieves, for subsequent use;
2), by Cortex Magnoliae Officinalis, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Fructus Jujubae, the Rhizoma Pinelliae, Rhizoma Corydalis prepare in proportion, be ground into powder through pulverizer and cross 90 mesh sieves, naturally drying, for subsequent use;
3), by step 1) and 2) in each component powders mix, add pure water and decoct twice, first time adds the little fire of 8 times of pure water and decocts 1 hour, and second time adds 4 times of little fire of pure water and decocts half an hour, then collecting decoction filtering, for subsequent use;
4) Radix Notoginseng, by remaining, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Radix Rehmanniae prepare in proportion, are ground into powder and cross 80 mesh sieves, naturally dry through pulverizer, for subsequent use;
5), by component powders each in step 4) mix, add the ethanol of 4 ~ 6 times 70% ~ 80%, reflux 3 ~ 5 hours, extract and filter acquisition filtrate; Then in remaining medicinal residues, again add the ethanol of 2 ~ 4 times 65% ~ 75%, reflux 2 ~ 3 hours, extract and filter acquisition filtrate; The filtrate of twice acquisition is combined, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
6), by above-mentioned steps 5) in obtain dry cream carry out micronizing powdered and cross 200 mesh sieves, then powder is added the collecting decoction in step 3), mixing shake up and can obtain.
The above-mentioned Chinese medicine composition pharmaceutical solutions produced may be used for oral, if can respectively drink the morning, noon and afternoon once and long-term drink, and better effects if.
embodiment 2:
The present invention can raw materials quality be preferably also (gram):
Cortex Magnoliae Officinalis 12g Poria 10g Fructus Evodiae 10g
Radix Astragali 12g Radix Glycyrrhizae 12g Radix Notoginseng 15g
Radix Et Rhizoma Rhei 10g Radix Paeoniae Alba 12g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 15g Fructus Toosendan 10g Lignum Dalbergiae Odoriferae 13g
Rhizoma Anemones Altaicae 12g Radix Asparagi 8g thief bone 10g
Rhizoma Pinelliae 12g Rhizoma Corydalis 13g Radix Rehmanniae 10g
Fructus Jujubae 16g.
Preparation method is as embodiment 1.
embodiment 3:
The present invention can raw materials quality be preferably also (gram):
Cortex Magnoliae Officinalis 15g Poria 12g Fructus Evodiae 9g
Radix Astragali 15g Radix Glycyrrhizae 10g Radix Notoginseng 12g
Radix Et Rhizoma Rhei 12g Radix Paeoniae Alba 10g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 12g Fructus Toosendan 14g Lignum Dalbergiae Odoriferae 12g
Rhizoma Anemones Altaicae 8g Radix Asparagi 8g thief bone 12g
Rhizoma Pinelliae 10g Rhizoma Corydalis 8g Radix Rehmanniae 10g
Fructus Jujubae 15g.
Preparation method is as embodiment 1.
embodiment 4:
The present invention can raw materials quality be preferably also (gram):
Cortex Magnoliae Officinalis 18g Poria 15g Fructus Evodiae 12g
Radix Astragali 16g Radix Glycyrrhizae 12g Radix Notoginseng 15g
Radix Et Rhizoma Rhei 13g Radix Paeoniae Alba 15g Fructus Citri Sarcodactylis 12g
Rhizoma Dioscoreae 16g Fructus Toosendan 14g Lignum Dalbergiae Odoriferae 16g
Rhizoma Anemones Altaicae 10g Radix Asparagi 12g thief bone 15g
Rhizoma Pinelliae 16g Rhizoma Corydalis 13g Radix Rehmanniae 12g
Fructus Jujubae 18g.
Preparation method is as embodiment 1.
embodiment 5 :
The present invention can raw materials quality be preferably also (gram):
Cortex Magnoliae Officinalis 16g Poria 18g Fructus Evodiae 15g
Radix Astragali 14g Radix Glycyrrhizae 15g Radix Notoginseng 18g
Radix Et Rhizoma Rhei 15g Radix Paeoniae Alba 18g Fructus Citri Sarcodactylis 14g
Rhizoma Dioscoreae 18g Fructus Toosendan 16g Lignum Dalbergiae Odoriferae 14g
Rhizoma Anemones Altaicae 12g Radix Asparagi 13g thief bone 13g
Rhizoma Pinelliae 18g Rhizoma Corydalis 15g Radix Rehmanniae 15g
Fructus Jujubae 18g.
Preparation method is as embodiment 1.
embodiment 6 :
The present invention can raw materials quality be preferably also (gram):
Cortex Magnoliae Officinalis 15g Poria 18g Fructus Evodiae 15g
Radix Astragali 16g Radix Glycyrrhizae 15g Radix Notoginseng 20g
Radix Et Rhizoma Rhei 12g Radix Paeoniae Alba 20g Fructus Citri Sarcodactylis 16g
Rhizoma Dioscoreae 16g Fructus Toosendan 18g Lignum Dalbergiae Odoriferae 15g
Rhizoma Anemones Altaicae 15g Radix Asparagi 15g thief bone 12g
Rhizoma Pinelliae 16g Rhizoma Corydalis 16g Radix Rehmanniae 13g
Fructus Jujubae 20g.
Preparation method is as embodiment 1.
Above-described embodiment is only the several of the numerous embodiment of the present invention, and as strengthened in the ratio in technical scheme by each formula or reducing dose, obtained this treatment chronic colitis preparation curative effect is also unaffected, also will drop within the scope of the present invention.

Claims (4)

1. treat the Chinese medicine preparation of chronic colitis for one kind, it is characterized in that, this preparation is the composite preparation be prepared into by Cortex Magnoliae Officinalis, Poria, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Rhizoma Pinelliae, Rhizoma Corydalis, the Radix Rehmanniae and Fructus Jujubae, and wherein the quality proportioning of each component is:
2. the Chinese medicine preparation for the treatment of chronic colitis according to claim 1, is further characterized in that, wherein the quality proportioning of each component is:
3. the Chinese medicine preparation for the treatment of chronic colitis according to claim 1 and 2, is further characterized in that, wherein the quality proportioning of each component is:
4., according to a kind of preparation method for the treatment of the Chinese medicine preparation of chronic colitis of claims 1 or 2 described in any one, it is characterized in that, it comprises the steps:
1), by Poria put into pannikin and carry out stir-fry dish cooked in a small wok, meaning the food is prepared with special care to surperficial micro-Jiao, then pulverize through pulverizer and cross 80 mesh sieves, for subsequent use;
2), by Cortex Magnoliae Officinalis, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Fructus Jujubae, the Rhizoma Pinelliae, Rhizoma Corydalis prepare in proportion, be ground into powder through pulverizer and cross 90 mesh sieves, naturally drying, for subsequent use;
3), by step 1) and 2) in each component powders mix, add pure water and decoct twice, first time adds the little fire of 10 times of pure water and decocts 1 hour, extract filtrate for subsequent use, second time adds the little fire of 6 times of pure water and decocts half an hour, then collecting decoction filtering, for subsequent use;
4) Radix Notoginseng, by remaining, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Radix Rehmanniae prepare in proportion, are ground into powder and cross 80 mesh sieves, naturally dry through pulverizer, for subsequent use;
5), by step 4) in each component powders mix, add the ethanol of 4 ~ 6 times 70% ~ 80%, reflux 3 ~ 5 hours, extract filter obtain filtrate; Then in remaining medicinal residues, again add the ethanol of 2 ~ 4 times 65% ~ 75%, reflux 2 ~ 3 hours, extract and filter acquisition filtrate; The filtrate of twice acquisition is combined, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
6), by above-mentioned steps 5) in obtain dry cream carry out micronizing powdered and cross 200 mesh sieves, then powder is added step 3) in collecting decoction, mixing shake up and can obtain.
CN201410124716.2A 2014-03-31 2014-03-31 A kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof Expired - Fee Related CN103860844B (en)

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