CN103860844A - Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof Download PDF

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CN103860844A
CN103860844A CN201410124716.2A CN201410124716A CN103860844A CN 103860844 A CN103860844 A CN 103860844A CN 201410124716 A CN201410124716 A CN 201410124716A CN 103860844 A CN103860844 A CN 103860844A
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radix
rhizoma
fructus
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chinese medicine
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CN103860844B (en
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袁志贤
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Hu Jing
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system

Abstract

The invention discloses a traditional Chinese medicine preparation for treating chronic colitis and a preparation method thereof. The preparation is a liquid composition preparation prepared from mangnolia officinalis, poria cocos, fructus evodiae, astragalus membranaceus, liquorice, pseudo-ginseng, rheum officinale, radix paeoniae alba, citrus chirocarpus, Chinese yam, toosendan fruit, lignum dalbergiae odoriferae, rhizoma acori graminei, radix asparagi, bone of sea poacher, pinellia ternate, rhizoma corydalis, radix rehmanniae and red dates by virtue of the steps of crushing, decoction, ethanol extraction, mixing and the like. The traditional Chinese medicine preparation has an obvious effect in treating the chronic colitis. A composition prepared by the preparation method according to the drug matching has the effect of regulating the intestinal tract and the entrails by adopting a dialectical method, is free of toxic and side effects and stable in effect and plays a curative effect of getting twofold results with half the effort in comparison with Western medicines.

Description

A kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of colitis, be specifically related to a kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof.
Background technology
Intestinal refers to the digestive tube from stomach pylorus to anus, and intestinal is one section the longest in digestive tube, is also most important one section of function.Intestinal is the digestive organs of human body maximum, is also the toxin expelling organ of human body maximum.From physiology, anatomy, cytological angle, large intestine toxin expelling accounts for the more than 85% of human detoxification; 80% immune structure of human body is around intestinal, and endotoxic accumulation is the killer of autoimmune power.
Chronic colitis is a kind of common disease, clinically shows as that times of defecation increases, five indigested foods or as water sample or viscid, with borborygmus, stomachache, very all void of person's spleen kidney, lets out just before dawn more.General sick position is at intestinal, but involves the internal organs such as spleen, stomach, liver, kidney, with the passing of time becomes thin, asthenia.This card is one of clinical common the spleen-stomach disease, and sickness rate is high, easily outbreak repeatedly, and touching difficulty more, having a strong impact on people's orthobiosis, and with the passing of time canceration rate reaches 5% left and right.Although it is not very few to be used for the treatment of at present the medicine of colitis, Western medicine is cured the symptoms, not the disease, and has used of a specified duration and has easily developed immunity to drugs, and side effect is larger, infringement liver, kidney and hemocyte, and also drug effect is unstable, easily outbreak repeatedly.
Summary of the invention
Object of the present invention is for above-mentioned deficiency, on the basis of secret prescription handed down in the family from generation to generation, in conjunction with modern Chinese and western medicine technology, a kind of Chinese medicine preparation for the treatment of chronic colitis is provided, is to provide specifically this Chinese medicine preparation and preparation method thereof, colitis therapeutic effect of the present invention is obvious, and nontoxic, have no side effect, effect stability, reparation technology is simple and easy to do.
Technical scheme of the present invention is as described below:
Preparation of the present invention is the composite preparation being prepared into by Cortex Magnoliae Officinalis, Poria, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Rhizoma Pinelliae, Rhizoma Corydalis, the Radix Rehmanniae and Fructus Jujubae, and wherein the quality proportioning of each component is:
Cortex Magnoliae Officinalis 12-20g Poria 10-22g Fructus Evodiae 8-18g
Radix Astragali 10-18g Radix Glycyrrhizae 8-15g Radix Notoginseng 10-20g
Radix Et Rhizoma Rhei 8-16g Radix Paeoniae Alba 12-20g Fructus Citri Sarcodactylis 8-16g
Rhizoma Dioscoreae 10-18g Fructus Toosendan 10-18g Lignum Dalbergiae Odoriferae 10-18g
Rhizoma Anemones Altaicae 8-15g Radix Asparagi 6-15g thief bone 8-15g
Rhizoma Pinelliae 10-18g Rhizoma Corydalis 8-16g Radix Rehmanniae 8-15g
Fructus Jujubae 10-20g.
In order to obtain better effect, the present invention preferably raw material mass mixture ratio is:
Cortex Magnoliae Officinalis 12-18g Poria 10-18g Fructus Evodiae 8-12g
Radix Astragali 12-18g Radix Glycyrrhizae 8-12g Radix Notoginseng 10-15g
Radix Et Rhizoma Rhei 8-12g Radix Paeoniae Alba 12-16g Fructus Citri Sarcodactylis 8-12g
Rhizoma Dioscoreae 10-15g Fructus Toosendan 10-14g Lignum Dalbergiae Odoriferae 10-15g
Rhizoma Anemones Altaicae 8-12g Radix Asparagi 6-10g thief bone 8-12g
Rhizoma Pinelliae 10-15g Rhizoma Corydalis 8-12g Radix Rehmanniae 8-12g
Fructus Jujubae 12-18g.
Certainly, in order to obtain further good effect, the present invention also preferably raw material mass mixture ratio be:
Cortex Magnoliae Officinalis 15g Poria 12g Fructus Evodiae 9g
Radix Astragali 15g Radix Glycyrrhizae 10g Radix Notoginseng 12g
Radix Et Rhizoma Rhei 12g Radix Paeoniae Alba 10g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 12g Fructus Toosendan 14g Lignum Dalbergiae Odoriferae 12g
Rhizoma Anemones Altaicae 8g Radix Asparagi 8g thief bone 12g
Rhizoma Pinelliae 10g Rhizoma Corydalis 8g Radix Rehmanniae 10g
Fructus Jujubae 15g.
The preparation method of above-mentioned treatment chronic colitis Chinese medicine preparation, comprises the steps:
1), Poria put into pannikin carry out stir-fry dish cooked in a small wok, meaning the food is prepared with special care to surperficial micro-Jiao, then pulverize and cross 80 mesh sieves through pulverizer, for subsequent use;
2), Cortex Magnoliae Officinalis, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Fructus Jujubae, the Rhizoma Pinelliae, Rhizoma Corydalis are prepared in proportion, be ground into powder and cross 90 mesh sieves through pulverizer, naturally drying, for subsequent use;
3), by step 1) and 2) in each component powders mix, add pure water to decoct twice, add for the first time 10 times of pure water to decoct 1 hour, extract filtrate for subsequent use; Add for the second time 6 times of pure water to decoct half an hour, then collecting decoction filtration, for subsequent use;
4), remaining Radix Notoginseng, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Radix Rehmanniae are prepared in proportion, be ground into powder and cross 80 mesh sieves through pulverizer, naturally drying, for subsequent use;
5), each component powders in step 4) is mixed, add the ethanol of 4~6 times 70%~80%, reflux 3~5 hours, extracts to filter and obtains filtrate; Then in remaining medicinal residues, again add the ethanol of 2~4 times 65%~75%, reflux 2~3 hours, extracts and filters acquisition filtrate; The filtrate of twice acquisition is combined, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
6), by above-mentioned steps 5) in the dry cream that obtains carry out micronizing powdered and cross 200 mesh sieves, then powder is added to 3) collecting decoction in step, mix and shake up and can make.
The above-mentioned Chinese medicine composition pharmaceutical solutions of producing can be for oral, if can each also long-term drink, better effects if of drinking in right amount once of morning, noon and afternoon.
Theoretical foundation of the present invention is:
Cortex Magnoliae Officinalis, is a kind of medicinal plants that belongs to Magnoliaceae, and growth district is mainly on the ground such as Sichuan, Hubei.Cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant is stopped up QI rising in reverse order, the fullness in the chest symptom such as breath with cough.Have that removing dampness intestinal stasis relieving, circulation of qi promoting are relievingd asthma, the effect of relieving dyspepsia expectorant, wind dispelling analgesia; Cortex Magnoliae Officinalis is reflexive causes saliva, gastric secretion, gastrointestinal peristalsis quickening, and has the digestant effect of stomach invigorating; Cortex Magnoliae Officinalis decoct has broad-spectrum antibacterial action, and external all have inhibitory action to staphylococcus aureus, Hemolytic streptococcus, diphtheria corynebacterium etc.; In addition, Cortex Magnoliae Officinalis regulates the effects such as smooth muscle, antiulcer, maincenter inhibition, blood pressure lowering, resisting pathogenic microbes, antitumor in addition.
Poria, sweet in the mouth, light, property is flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Fructus Evodiae, nature and flavor heat, taste hardship, pungent, " herbal classic " records Fructus Evodiae: " main warming the middle warmer and descending qi, pain relieving, cough with dyspnea cold and heat, dehumidifying, arthralgia due to stagnation of blood, by ailment said due to cold or exposure, loosing the interspaces of skin and muscles." Compendium of Material Medica record Fructus Evodiae: " dissipating depression of QIization is stagnant, controls acid regurgitation, the cloudy sputum headache of fainting, insidious stomachache, hernia dysentery, mouthpiece's aphtha." there is the merit of dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, be used for the treatment of that liver insufficiency of stomach is cold, the disease such as headache or gastralgia due to cloudy turbid superinverse.
The Radix Astragali, has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effects such as detoxification granulation promoting.Cure mainly the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts and do not hold back for a long time.
Radix Glycyrrhizae, is a kind of tonification Chinese herbal medicine, and medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong etc.
Radix Notoginseng, for the dissipating blood stasis that stops blooding, subduing swelling and relieving pain.Cure mainly haematemesis, hemoptysis, hematuria, has blood in stool, dysentery, metrorrhagia, postpartum hemorrhage, traumatic hemorrhage, injury from falling down, obstruction of qi in the chest and cardialgia, gastral cavity is coerced the long-pending piece of Tong , mass in the abdomen of a specified duration, blood stasis amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, sore, carbuncle and painful swelling; With other drug matchings of the present invention, treatment colitis successful.
Radix Et Rhizoma Rhei, bitter in the mouth, cold in nature, return stomach, spleen, large intestine, liver, pericardium channel, can purging heat and dredging bowels, eliminating blood stasis and inducing menstruation, removing pathogenic heat from blood and toxic substance from the body.For blood stasis amenorrhea, traumatic injury, jaundice due to damp-heat, heat in blood is told nosebleed, excess-heat constipation, stagnant stomachache, abdominalgia with intestinal abscess, dysentery is not well, conjunctival congestion, pharyngeal swelling, carbuncle furuncle, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.There is stasis of blood bleeder for heat in blood, cure mainly acute Stomach duodenum Peptic ulcer bleeding.
The Radix Paeoniae Alba, bitter in the mouth, acid, is slightly cold, and returns Liver Channel.Nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, stimulates the menstrual flow, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery is had loose bowels, and has a headache dizzy.
Fructus Citri Sarcodactylis, bitter in the mouth, pungent, sweet, warm in nature, nontoxic, enters liver, spleen, stomach three warps, has depressed liver-energy dispersing and QI regulating, and effect of gastrointestinal pain relieving, for stagnation of liver-QI and stomach-QI, gastral cavilty feeling of fullness, lack of appetite vomiting, has obvious inhibitory action to intestinal tube smooth muscle, and enterospasm is had to spasmolysis; There is expansion hat Like blood vessel, increase the effect of coronary flow; When high concentration, can weaken myocardial contraction, decreased heart rate, reduces blood pressure, with Ischemic myocardium; There is certain phlegm-dispelling functions.
Rhizoma Dioscoreae, sweet in the mouth, profit cool in nature, enters lung, spleen, kidney channel, contains the material such as amylase, polyphenol oxidase, is conducive to taste digestive and absorptive functions, is the product of the medicine-food two-purpose of flat tonifying the spleen and stomach simply.No matter spleen sun loses or deficiency of stomach-YIN, all edible.With controlling, weakness of the spleen and stomach, lack of appetite body are tired, the disease such as have loose bowels together for normal and gastrointestinal drink clinically.Spleen reinforcing, supports lung, reinforces the kidney, and benefit essence; Cure mainly diarrhea due to hypofunction of the spleen, lack of appetite edema, cough and asthma due to lung deficiency, quenches one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.
Fructus Toosendan, nature and flavor hardship, cold; Slightly poisonous, return liver, small intestinal, urinary bladder channel.Soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Lignum Dalbergiae Odoriferae, property is pungent, warm, returns liver, spleen channel.Promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage; And the vomiting of colic of cold type pain or foul internal resistance stomachache.
Rhizoma Anemones Altaicae, nature and flavor are pungent, tepor, nontoxic; GUIXIN, liver, spleen channel, have waking up the patient from unconsciousness by dissipating phlegm, calms the nerves, and a surname is wet to be amusing, effect of removing toxic substances; Main calentura coma, epilepsy, deafness with qi stagnation, dreaminess is forgetful, abdominal distention uncomfortable in chest, inappetence, rheumatic arthralgia, carbuncle, the diseases such as scabies.
Radix Asparagi, nature and flavor: sweet, bitter, cold; Return lung, kidney channel.For fever due to yin deficiency, dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat quench one's thirst, the symptom such as dryness of the intestine constipation, consumptive lung disease, lung abscess, diphtheria; Various bacteria is had to inhibitory action, have anti-tumor activity, energy YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire, remove dry pathogenic fire reducing.
Os Sepiae, contain calcium carbonate, can in and gastric acid, alleviate acid regurgitation and heartburn symptom, can promote again ulcer surface inflammation to absorb, stop hemorrhage, therefore alleviate local pain. can make antacid. experiment shows: its compound preparation Medicinal powder of cuttlefish and firtillary bulb have obvious absorption pepsin and in and the effect of gastric acid, can reduce the stimulation of gastric acid to gastric ulcer face, also reduce the Digestion of protease to ulcer surface, be conducive to the intestines and stomach with this.
The Rhizoma Pinelliae, nature and flavor are pungent, and temperature is poisonous.Return spleen, stomach, lung meridian.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effects such as dissolving lump and resolving mass; Cure mainly cough with asthma abundant expectoration, vomiting regurgitation, feeling of oppression and fullness in the chest and epigastrium, the diseases such as dizzy, uneasy sleeping at night, gall subcutaneous nodule, swollen ulcer drug of having a headache.
Rhizoma Corydalis, warm in nature, acrid in the mouth, hardship, return liver, spleen, stomach warp, is the quality goods of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, is especially world-famous for effect of pain relieving.Cure mainly the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
The Radix Rehmanniae, sweet in the mouth, hardship, cold in nature; GUIXIN, liver, lung meridian.Heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, be usually used in treating the diseases such as hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.With other drug matchings of the present invention, evident in efficacy.
Fructus Jujubae, Fructus Jujubae sweet in the mouth warm in nature, contain protein, fat, sugar, calcium, phosphorus, ferrum, magnesium and abundant vitamin, contain in addition carotene etc., nutrition is very abundant, has spleen reinforcing, nourishes blood, sedative action, tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, the function of loosening bowel to relieve constipation, has lung moistening spleen invigorating, cough-relieving, tonifying five ZANG-organs, the deficient effect for the treatment of.
From China's Traditional Chinese Medicine angle, the differential diagnosis of diseases of the chronic colitis traditional Chinese medical science belongs to the categories such as " having loose bowels ", " Hakuri ".Clinical symptoms is with chronic diarrhea, stomachache, row's mucus just, hemafecia is main, be chronic repeatability outbreak or persistence outbreak, the primary disease course of disease is longer, how because chronic dietary is careless, overstrain internal injury, cause weakness of the spleen and stomach, therefore the compositions obtaining by the above-mentioned drug matching of the present invention and preparation method, adopts dialectical method effectively to reach effect of conditioning intestinal and the vital organs of the human body, has no side effect, effect stability reaches the curative effect of getting twice the result with half the effort compared with Western medicine.
clinical experiment 1:
1), observing time: in the situation that technical solution of the present invention does not disclose, select in April, 2011 to 2011 year JIUYUE 6 months.
2), the object of observation: select 10 routine chronic colitis cases in Shenzhen City, Guangdong Province Gastroenterology dept. of institute of traditional Chinese medicine: male 5 examples, female's 5 examples; Age: 41-55 years old 5 example, 62-75 years old 5 example; Occupation: common working clan's 5 examples, retired person 5 examples.Disease: repeatedly stomachache, the abdominal distention of outbreak, suffer from diarrhoea, rush down lower mucus or bloody purulent stool, stage of attack, defecate more than 3 times/day, companion's defecation is not freely or tenesmus; Tongue fur is how yellow greasy or greasy in vain; All disease is just all made a definite diagnosis through intestinal fiberscopy.
3), using method: preparation oral liquid of the present invention is being taken after the meal half an hour, and every day 3 times, each 200ml, 2 months was 1 course for the treatment of, and 3 courses for the treatment of are as observation of curative effect.
4), observing effect:
Taking continuously after 3 courses for the treatment of, clinical symptoms, sign disappear, intestinal fiberscope check is normal, and intestinal mucosa pathological changes is recovered normal 4 examples, and clinical symptoms obviously alleviates, sign disappears substantially, intestinal fiberscope check takes a turn for the better, 4 examples that intestinal mucosa pathological changes is obviously improved, and before and after treatment, clinical symptoms and sign are without improvement, intestinal fiberscope check is without 2 examples that take a turn for the better, total effective rate 80%.
clinical experiment 2 :
1), observing time: in the situation that technical solution of the present invention does not disclose, select 6 months of year July in February, 2011 to 2011.
2), the object of observation: 20 routine cases are selected by Gastroenterology dept. of institute of traditional Chinese medicine in Futian District, Shenzhen City, Guangdong Province: male 10 examples, female's 10 examples; Age: 33-55 years old 10 example, 58-75 years old 10 example; Occupation: post civil servant 10 examples that once assumed the leadership, common teachers 10 examples.Disease: repeatedly stomachache, the abdominal distention of outbreak, suffer from diarrhoea, rush down lower mucus or bloody purulent stool, stage of attack, defecate more than 3 times/day, companion's defecation is not freely or tenesmus; Tongue fur is how yellow greasy or greasy in vain; All disease is just all made a definite diagnosis through intestinal fiberscopy.
3), using method: preparation oral liquid of the present invention is being taken after the meal half an hour, and every day 3 times, each 200ml, 2 months was 1 course for the treatment of, and 3 courses for the treatment of are as observation of curative effect.
4), observing effect:
Taking continuously after 3 courses for the treatment of, clinical symptoms, sign disappear, intestinal fiberscope check is normal, and intestinal mucosa pathological changes is recovered normal 10 examples, and clinical symptoms obviously alleviates, sign disappears substantially, intestinal fiberscope check takes a turn for the better, 5 examples that intestinal mucosa pathological changes is obviously improved, and before and after treatment, clinical symptoms and sign are without improvement, intestinal fiberscope check is without 5 examples that take a turn for the better, total effective rate 75%.
clinical experiment 3 :
1), observing time: in the situation that technical solution of the present invention does not disclose, select 6 months of year November in June, 2013 to 2013.
2), the object of observation: select 30 routine cases in Gastroenterology dept. of Song Gang the People's Hospital, Shenzhen City, Guangdong Province: male 14 examples, female's 16 examples; Age: 35-55 years old 16 example, 60-75 years old 14 example; Occupation: the common master of private enterprise 14 examples, common retired professor's 16 examples.Disease: repeatedly stomachache, the abdominal distention of outbreak, suffer from diarrhoea, rush down lower mucus or bloody purulent stool, stage of attack, defecate more than 3 times/day, companion's defecation is not freely or tenesmus; Tongue fur is how yellow greasy or greasy in vain; All disease is just all made a definite diagnosis through intestinal fiberscopy.
3), using method: preparation oral liquid of the present invention is being taken after the meal half an hour, and every day 3 times, each 200ml, 2 months was 1 course for the treatment of, and 3 courses for the treatment of are as observation of curative effect.
4), observing effect:
Taking continuously after 3 courses for the treatment of, clinical symptoms, sign disappear, intestinal fiberscope check is normal, and intestinal mucosa pathological changes is recovered normal 20 examples, and clinical symptoms obviously alleviates, sign disappears substantially, intestinal fiberscope check takes a turn for the better, 5 examples that intestinal mucosa pathological changes is obviously improved, and before and after treatment, clinical symptoms and sign are without improvement, intestinal fiberscope check is without 5 examples that take a turn for the better, total effective rate 84%.
In conjunction with above clinical data and theoretical foundation of the present invention, visible beneficial effect of the present invention is, the preparation that the present invention makes has good result for treatment chronic colitis, and nontoxic, have no side effect, and effect stability, reparation technology is simple and easy to do. ?
Detailed description of the invention
Below in conjunction with embodiment, the present invention is explained detailedly:
embodiment 1:
Preparation of the present invention is the composite preparation being prepared into by Cortex Magnoliae Officinalis, Poria, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Rhizoma Pinelliae, Rhizoma Corydalis, the Radix Rehmanniae and Fructus Jujubae, and wherein the quality proportioning of each component is:
Cortex Magnoliae Officinalis 12g Poria 10g Fructus Evodiae 10g
Radix Astragali 12g Radix Glycyrrhizae 12g Radix Notoginseng 15g
Radix Et Rhizoma Rhei 10g Radix Paeoniae Alba 12g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 15g Fructus Toosendan 15g Lignum Dalbergiae Odoriferae 13g
Rhizoma Anemones Altaicae 12g Radix Asparagi 8g thief bone 10g
Rhizoma Pinelliae 12g Rhizoma Corydalis 13g Radix Rehmanniae 10g
Fructus Jujubae 16g.
The preparation method of above-mentioned treatment chronic colitis Chinese medicine preparation, comprises the steps:
1), Poria put into pannikin carry out stir-fry dish cooked in a small wok, meaning the food is prepared with special care to surperficial micro-Jiao, then pulverize and cross 80 mesh sieves through pulverizer, for subsequent use;
2), Cortex Magnoliae Officinalis, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Fructus Jujubae, the Rhizoma Pinelliae, Rhizoma Corydalis are prepared in proportion, be ground into powder and cross 90 mesh sieves through pulverizer, naturally drying, for subsequent use;
3), by step 1) and 2) in each component powders mix, add pure water to decoct twice, add for the first time the little fire of 8 times of pure water to decoct 1 hour, add for the second time 4 times of little fire of pure water to decoct half an hour, then collecting decoction filtering, for subsequent use;
4), remaining Radix Notoginseng, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Radix Rehmanniae are prepared in proportion, be ground into powder and cross 80 mesh sieves through pulverizer, naturally drying, for subsequent use;
5), each component powders in step 4) is mixed, add the ethanol of 4~6 times 70%~80%, reflux 3~5 hours, extracts to filter and obtains filtrate; Then in remaining medicinal residues, again add the ethanol of 2~4 times 65%~75%, reflux 2~3 hours, extracts and filters acquisition filtrate; The filtrate of twice acquisition is combined, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
6), by above-mentioned steps 5) in obtain dry cream carry out micronizing powdered and cross 200 mesh sieves, then powder is added to the collecting decoction in step 3), mix shake up and can make.
The above-mentioned Chinese medicine composition pharmaceutical solutions of producing can be for oral, if can respectively drink once and long-term drink better effects if the morning, noon and afternoon.
embodiment 2:
The present invention also preferably raw materials quality be (gram):
Cortex Magnoliae Officinalis 12g Poria 10g Fructus Evodiae 10g
Radix Astragali 12g Radix Glycyrrhizae 12g Radix Notoginseng 15g
Radix Et Rhizoma Rhei 10g Radix Paeoniae Alba 12g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 15g Fructus Toosendan 10g Lignum Dalbergiae Odoriferae 13g
Rhizoma Anemones Altaicae 12g Radix Asparagi 8g thief bone 10g
Rhizoma Pinelliae 12g Rhizoma Corydalis 13g Radix Rehmanniae 10g
Fructus Jujubae 16g.
Preparation method is as embodiment 1.
embodiment 3:
The present invention also preferably raw materials quality be (gram):
Cortex Magnoliae Officinalis 15g Poria 12g Fructus Evodiae 9g
Radix Astragali 15g Radix Glycyrrhizae 10g Radix Notoginseng 12g
Radix Et Rhizoma Rhei 12g Radix Paeoniae Alba 10g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 12g Fructus Toosendan 14g Lignum Dalbergiae Odoriferae 12g
Rhizoma Anemones Altaicae 8g Radix Asparagi 8g thief bone 12g
Rhizoma Pinelliae 10g Rhizoma Corydalis 8g Radix Rehmanniae 10g
Fructus Jujubae 15g.
Preparation method is as embodiment 1.
embodiment 4:
The present invention also preferably raw materials quality be (gram):
Cortex Magnoliae Officinalis 18g Poria 15g Fructus Evodiae 12g
Radix Astragali 16g Radix Glycyrrhizae 12g Radix Notoginseng 15g
Radix Et Rhizoma Rhei 13g Radix Paeoniae Alba 15g Fructus Citri Sarcodactylis 12g
Rhizoma Dioscoreae 16g Fructus Toosendan 14g Lignum Dalbergiae Odoriferae 16g
Rhizoma Anemones Altaicae 10g Radix Asparagi 12g thief bone 15g
Rhizoma Pinelliae 16g Rhizoma Corydalis 13g Radix Rehmanniae 12g
Fructus Jujubae 18g.
Preparation method is as embodiment 1.
embodiment 5 :
The present invention also preferably raw materials quality be (gram):
Cortex Magnoliae Officinalis 16g Poria 18g Fructus Evodiae 15g
Radix Astragali 14g Radix Glycyrrhizae 15g Radix Notoginseng 18g
Radix Et Rhizoma Rhei 15g Radix Paeoniae Alba 18g Fructus Citri Sarcodactylis 14g
Rhizoma Dioscoreae 18g Fructus Toosendan 16g Lignum Dalbergiae Odoriferae 14g
Rhizoma Anemones Altaicae 12g Radix Asparagi 13g thief bone 13g
Rhizoma Pinelliae 18g Rhizoma Corydalis 15g Radix Rehmanniae 15g
Fructus Jujubae 18g.
Preparation method is as embodiment 1.
embodiment 6 :
The present invention also preferably raw materials quality be (gram):
Cortex Magnoliae Officinalis 15g Poria 18g Fructus Evodiae 15g
Radix Astragali 16g Radix Glycyrrhizae 15g Radix Notoginseng 20g
Radix Et Rhizoma Rhei 12g Radix Paeoniae Alba 20g Fructus Citri Sarcodactylis 16g
Rhizoma Dioscoreae 16g Fructus Toosendan 18g Lignum Dalbergiae Odoriferae 15g
Rhizoma Anemones Altaicae 15g Radix Asparagi 15g thief bone 12g
Rhizoma Pinelliae 16g Rhizoma Corydalis 16g Radix Rehmanniae 13g
Fructus Jujubae 20g.
Preparation method is as embodiment 1.
Above-described embodiment is only the several of the numerous embodiments of the present invention, and as each formula strengthened in the ratio in technical scheme or reducing dose, this treatment chronic colitis preparation curative effect making is also unaffected, within also will dropping on the scope of the present invention.

Claims (4)

1. treat the Chinese medicine preparation of chronic colitis for one kind, it is characterized in that, preparation of the present invention is the composite preparation being prepared into by Cortex Magnoliae Officinalis, Poria, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Aquilariae Resinatum, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Rhizoma Pinelliae, Rhizoma Corydalis, the Radix Rehmanniae and Fructus Jujubae, and wherein the quality proportioning of each component is:
Cortex Magnoliae Officinalis 12-20g Poria 10-22g Fructus Evodiae 8-18g
Radix Astragali 10-18g Radix Glycyrrhizae 8-15g Radix Notoginseng 10-20g
Radix Et Rhizoma Rhei 8-16g Radix Paeoniae Alba 12-20g Fructus Citri Sarcodactylis 8-16g
Rhizoma Dioscoreae 10-18g Fructus Toosendan 10-18g Lignum Dalbergiae Odoriferae 10-18g
Rhizoma Anemones Altaicae 8-15g Radix Asparagi 6-15g thief bone 8-15g
Rhizoma Pinelliae 10-18g Rhizoma Corydalis 8-16g Radix Rehmanniae 8-15g
Fructus Jujubae 10-20g.
2. the Chinese medicine preparation for the treatment of chronic colitis according to claim 1, is further characterized in that, wherein the quality proportioning of each component is:
Cortex Magnoliae Officinalis 12-18g Poria 10-18g Fructus Evodiae 8-12g
Radix Astragali 12-18g Radix Glycyrrhizae 8-12g Radix Notoginseng 10-15g
Radix Et Rhizoma Rhei 8-12g Radix Paeoniae Alba 12-16g Fructus Citri Sarcodactylis 8-12g
Rhizoma Dioscoreae 10-15g Fructus Toosendan 10-14g Lignum Dalbergiae Odoriferae 10-15g
Rhizoma Anemones Altaicae 8-12g Radix Asparagi 6-10g thief bone 8-12g
Rhizoma Pinelliae 10-15g Rhizoma Corydalis 8-12g Radix Rehmanniae 8-12g
Fructus Jujubae 12-18g.
3. the Chinese medicine preparation for the treatment of chronic colitis according to claim 1 and 2, is further characterized in that, wherein the quality proportioning of each component is:
Cortex Magnoliae Officinalis 15g Poria 12g Fructus Evodiae 9g
Radix Astragali 15g Radix Glycyrrhizae 10g Radix Notoginseng 12g
Radix Et Rhizoma Rhei 12g Radix Paeoniae Alba 10g Fructus Citri Sarcodactylis 8g
Rhizoma Dioscoreae 12g Fructus Toosendan 14g Lignum Dalbergiae Odoriferae 12g
Rhizoma Anemones Altaicae 8g Radix Asparagi 8g thief bone 12g
Rhizoma Pinelliae 10g Rhizoma Corydalis 8g Radix Rehmanniae 10g
Fructus Jujubae 15g.
4. a preparation method for the treatment of the Chinese medicine preparation of chronic colitis, is characterized in that, it comprises the steps:
1), Poria put into pannikin carry out stir-fry dish cooked in a small wok, meaning the food is prepared with special care to surperficial micro-Jiao, then pulverize and cross 80 mesh sieves through pulverizer, for subsequent use;
2), Cortex Magnoliae Officinalis, Fructus Evodiae, the Radix Astragali, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Fructus Citri Sarcodactylis, Fructus Jujubae, the Rhizoma Pinelliae, Rhizoma Corydalis are prepared in proportion, be ground into powder and cross 90 mesh sieves through pulverizer, naturally drying, for subsequent use;
3), by step 1) and 2) in each component powders mix, add pure water to decoct twice, add for the first time the little fire of 10 times of pure water to decoct 1 hour, extract filtrate for subsequent use, add for the second time 6 times of little fire of pure water to decoct half an hour, then collecting decoction filtration, for subsequent use;
4), remaining Radix Notoginseng, Rhizoma Dioscoreae, Fructus Toosendan, Lignum Dalbergiae Odoriferae, Rhizoma Anemones Altaicae, Radix Asparagi, crafty bone, the Radix Rehmanniae are prepared in proportion, be ground into powder and cross 80 mesh sieves through pulverizer, naturally drying, for subsequent use;
5), each component powders in step 4) is mixed, add the ethanol of 4~6 times 70%~80%, reflux 3~5 hours, extracts to filter and obtains filtrate; Then in remaining medicinal residues, again add the ethanol of 2~4 times 65%~75%, reflux 2~3 hours, extracts and filters acquisition filtrate; The filtrate of twice acquisition is combined, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
6), by above-mentioned steps 5) in obtain dry cream carry out micronizing powdered and cross 200 mesh sieves, then powder is added to the collecting decoction in step 3), mix and shake up and can make, the above-mentioned Chinese medicine composition pharmaceutical solutions of producing can be for oral, if can each also long-term drink, better effects if of drinking in right amount once of morning, noon and afternoon.
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