CN103432532B - Traditional Chinese medicine granules for treating nodules of breast and preparation method thereof - Google Patents
Traditional Chinese medicine granules for treating nodules of breast and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine granules for treating nodules of a breast and a preparation method thereof. The traditional Chinese medicine granules are prepared from the following main raw materials by weight: rhizoma cyperi, tulip bulb, rhizoma bolbostemmae, hawthorn, pangolin, radix rhapontied, radix curcumae, curcuma zedoary, spina gleditsiae, turtle shell, trichosanthes kirilowii, allium macrostemon, American ginseng, seed of cowherb and safflower carthamus. The traditional Chinese medicine granules can effectively relieve poor circulation of qi and blood caused by nodules of the breast, can be used for relaxing muscles and stimulating blood circulation, has good curative effect for nodules of the breast, is safe and effective and has no toxic and side effects.
Description
Technical field
The invention discloses a kind of Chinese medicine granules, especially a kind of Chinese medicine granules for the treatment of nodules of the breast and preparation method thereof.The invention belongs to traditional Chinese medicine field.
Background technology
Nodules of the breast (lump in breast), disease of tcm name, refers to the chronic benign lump that female breast portion is common, with lump in breast and distending pain for primary symptom, is common in young women.Nodules of the breast is found in the disease such as cyclomastopathy, Cystic hyperplasia of breast, mastofibroma of western medicine.Western medicine thinks that cyclomastopathy is relevant with ovarian dysfunction, and as lutein secretion reduces, estrogenic Secretion is to increasing.
Primary disease many with feelings will internal injury, be worried angry relevant.Stomach of foot Yang Ming through breast, liver channel of foot-Jueyin under breast, outside the capable breast of spleen meridian, if feelings will internal injury, angry then liver spleen pent-up of being worried, QI and blood is inverse disorderly, the not all right Tianjin of gas, and body fluid is condensed into expectorant; Multiple because of liver Wood restricts earth, cause spleen and can not transport wet, stomach can not the turbid descending, then the turbid interior life of expectorant; Stagnation of QI expectorant is turbid hinder in newborn network be then lump pain.Eight arteries and veins are subordinate in Liver and kidney, and chong channel is subordinate in sun bright, if pathogenic fire derived from stagnation of liver-QI, and the moon of consume Liver and kidney, then Chong and Ren channel disorder, " Shengji Zonglu " cloud: " rushing wantonly two warps, is above milk, and lower is moon water." so primary disease is how relevant to menstrual cycle.The basic pathogenesis of primary disease is that stagnation of QI expectorant coagulates, and Chong and Ren channel disorder is sick at stomach, liver, spleen three warp.With the lump that breast has shape not of uniform size, pain, cystic hyperplasia of breast class disease for main manifestations relevant to menstrual cycle.
Primary disease is more common in 20 ~ 40 years old women, shows as one-sided or bilateral breast and the single or multiple lump differed in size occurs, distending pain or tenderness, smooth surface, clear border, pushes away movable, increasess slowly, strong but pliable in texture or in cystic sense.Doublely see that lump and distending pain often disappear because of susceptible to anger elder, card belongs to stagnation of QI expectorant and coagulates; If often increase the weight of before menstruation comes, alleviator after menstruation is then Chong and Ren channel disorder.Most have a flat lump at the outside upper quadrant of breast, and that lays one's hand on has the tough hard tubercle of beans size, can have tenderness, and lump border owes clear, with surrounding tissue adhesion.Breast can have distending pain or twinge, the often growth and decline with susceptible to anger, and the moon is premenstrual to be increased the weight of, and alleviates after menstruation.
The Syndrome Types of TCM of nodules of the breast is a lot of, point two types had, point three types had, until four types, five types, six types, seven types etc., very or more.What have is excessively simple, and what have is too numerous. but always nothing more than stagnation of QI due to depression of the liver, stagnation of QI expectorant is solidifying, blood stasis expectorant solidifying, a discord, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency, QI and blood deficiency etc. are appointed in punching.Though the suggestion of each family is not the same, its pathogenesis all be unable to do without above-mentioned viewpoint.Doctor Li Jimin treats nodules of the breast (cyclomastopathy), dialectically is clinically divided into four types to carry out opinion controlling.
1. stagnation of QI due to depression of the liver: stagnation of liver-QI is not relaxed, breast distension, caking distending pain with susceptible to anger growth and decline, time have twinge, two side of body distending pains, bitter taste is irritated, and pale tongue with thin fur is white, stringy pulse or thin string.
2. Chong and Ren channel disorder: breast lumps, dull pain or twinge, localized pain.Premenstrual lump obviously increases, through after reduce deliquescing, or companion's menoxenia, dysmenorrhea, the disease such as infertile.Light red tongue tongue is white, and thready pulse moistens.
3. insufficiency of the spleen expectorant coagulates: lump in breast is comparatively large, but poor growth, the hard distending pain of matter, smooth surface, what push away can move, and clear border, mammary contour is constant.Thin white fur of tongue, stringy and rolling pulse.
4. blood stasis due to renal deficiency: breast caking with the passing of time, twinge or have a dull ache, fix by sore spot.Companion's soreness of waist is weak, and through water is few, color is light, or amenorrhea, the disease such as infertile.There is petechia on the dark or tongue limit of tongue, white and thin fur, deep-thready pulse.
In the method for existing treatment nodules of the breast, Chinese patent CN:200910229341.10 disclosed in 2009 a kind of " a kind of prescription for the treatment of nodules of the breast " by name, be that raw material is made by Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Cyperi, Radix Curcumae, Fructus Trichosanthis, Radix Rhapontici, Spica Prunellae, Rhizoma Bolbostematis, Rhizoma Curculiginis, Herba Epimedii, stir-baked SQUAMA MANITIS, main dosage form is decoction, it is desirable that effect for treatment nodules of the breast is also not so good as granule, can cause extra burden to the health of patient.
Summary of the invention
For the present situation of existing treatment nodules of the breast deficiency, an object of the present invention is to provide a kind of Chinese medicine granules for the treatment of nodules of the breast, have easy to carry, action effect is obvious, the effect playing blood circulation promoting and blood stasis dispelling that can be very fast, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine granules.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine granules for nodules of the breast, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 10-20 part, Pseudobulbus Cremastrae Seu Pleiones 10-20 part, Rhizoma Bolbostematis 10-20 part, Fructus Crataegi 10-20 part, Squama Manis 10-20 part, Radix Rhapontici 20-30 part, Radix Curcumae 20-30 part, Rhizoma Curcumae 20-30 part, Spina Gleditsiae 25-35 part, Carapax Trionycis 25-35 part, Fructus Trichosanthis 25-35 part, Bulbus Allii Macrostemonis 25-35 part, Radix Panacis Quinquefolii 30-40 part, Semen Vaccariae 30-40 part, Flos Carthami 30-40 part.
Treat a Chinese medicine granules for nodules of the breast, optimum ratio, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 13-18 part, Pseudobulbus Cremastrae Seu Pleiones 13-18 part, Rhizoma Bolbostematis 13-18 part, Fructus Crataegi 13-18 part, Squama Manis 13-18 part, Radix Rhapontici 23-28 part, Radix Curcumae 23-28 part, Rhizoma Curcumae 23-28 part, Spina Gleditsiae 28-33 part, Carapax Trionycis 28-33 part, Fructus Trichosanthis 28-33 part, Bulbus Allii Macrostemonis 28-33 part, Radix Panacis Quinquefolii 33-38 part, Semen Vaccariae 33-38 part, Flos Carthami 33-38 part.
Treat a Chinese medicine granules for nodules of the breast, better preferred proportioning, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 15 parts, Pseudobulbus Cremastrae Seu Pleiones 15 parts, Rhizoma Bolbostematis 15 parts, Fructus Crataegi 15 parts, Squama Manis 15 parts, Radix Rhapontici 25 parts, Radix Curcumae 25 parts, Rhizoma Curcumae 25 parts, Spina Gleditsiae 30 parts, Carapax Trionycis 30 parts, Fructus Trichosanthis 30 parts, Bulbus Allii Macrostemonis 30 parts, Radix Panacis Quinquefolii 35 parts, Semen Vaccariae 35 parts, 35 parts, Flos Carthami.
The preparation method of above-mentioned Chinese medicine granules, preparation process is as follows:
1. Fructus Crataegi, Squama Manis, Carapax Trionycis, Semen Vaccariae slow fire being fried 5-15 minute, frying to drying in the air after giving out fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Panacis Quinquefolii, Flos Carthami, Spina Gleditsiae, Bulbus Allii Macrostemonis altogether pulverization cross 80-120 mesh sieve, must medicamental pulverata be mixed for subsequent use;
3. by Rhizoma Bolbostematis, Radix Rhapontici, Rhizoma Cyperi, Rhizoma Curcumae, Fructus Trichosanthis, decoct with water 2 times, 2.0 hours first times, filter, obtain filtrate 1; Filtering residue after filtering is added water and carries out second time and decoct, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed with filtrate 2 and decocts 1 hour again, standing 20-30 hour, again filters, obtains filtrate for subsequent use;
4. by step 2. in gained mixing medicamental pulverata pour into step 3. in gained filtrate in, mix homogeneously, standing cold preservation 30 hours, is concentrated into paste;
5. get appropriate Icing Sugar and dry 1-2 hour at 60 DEG C, be placed in container, add step 4. in gained paste thing stirring and evenly mixing, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 10-20 mesh sieve crossed by soft material, makes wet granular;
6. wet granular bake drying step 5. made, dry temperature is 60-100 DEG C, namely obtains this Chinese medicine granules after cooling.
Above-mentioned preparation method, preferred scheme is: step 1. slow fire fries 8-13 minute (preferably 10 minutes).
Above-mentioned preparation method, preferred scheme is: 2. step crosses 90-110 mesh sieve (preferably 100 mesh sieves).
Above-mentioned preparation method, preferred scheme is: 3. step leaves standstill 23-28 hour (preferably 25 hours).
Above-mentioned preparation method, preferred scheme is: 5. step dries 1.3-1.8 hour (preferably 1.5 hours).
Above-mentioned preparation method, preferred scheme is: 5. step crosses 13-18 mesh sieve (preferably 15 mesh sieves).
Above-mentioned preparation method, preferred scheme is: step 6. baking temperature is 70-90 DEG C (preferably 80 DEG C).
Using method: for making the present invention reach optimum therapeuticing effect, time edible, takes after 1 hour after the meal, with warm boiled water, and 3 times on the one, each 10 grams.
This Chinese medicine granules, can also relaxing muscles and tendons to promote blood circulation to the Be very effective of nodules of the breast, not only blood circulation promoting and blood stasis dispelling, and QI and blood regulating, improves patient for a long time because of the slight illness that nodules of the breast brings, and the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
Treat a Chinese medicine granules for nodules of the breast, the pharmacological effect of each crude drug is respectively:
Rhizoma Cyperi: pungent micro-hardship is sweet, flat.Removing food stagnancy pain relieving fried by vinegar, and removing obstruction in the collateral to relieve pain fried by wine, resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Pseudobulbus Cremastrae Seu Pleiones: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For excess-heat carbuncle, carbuncle furunculosis, scrofula tuberculosis, innominate toxic swelling.
Rhizoma Bolbostematis: bitter, cool.Eliminating stagnation poison, subduing inflammation.Control acute mastitis, scrofula sucutaneous nodule, sore swollen toxin and snakeworm poison.
Fructus Crataegi: acid is sweet, tepor.Help digestion long-pending, dissipating blood stasis blood, expelling tenia.Control meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.
Squama Manis: Squama Manis salty in the mouth, cold nature enters liver, stomach two warp.Effect: detumescence suppuration, scattered silt dredging collateral, stimulate the menstrual flow, stimulating milk secretion, invigorating blood circulation analgesia.Cure mainly: carbuncle skin ulcer is swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, hemostasis, disease crust are gathered.
Radix Rhapontici: bitter salty, cold.Heat-clearing and toxic substances removing, detumescence and apocenosis, stimulating milk secretion, logical muscle arteries and veins.Control carbuncle carbuncle on the back, breast swell and pain.Galactostasis, scrofula malignant boil, arthralgia chiefly caused by damp pathogen muscle arteries and veins is restrained, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.
Radix Curcumae: arduous, cool.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.
Spina Gleditsiae: swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy.
Carapax Trionycis: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.
Fructus Trichosanthis: sweetness and bitterness, cold.Lung moistening, reduces phlegm, eliminating stagnation, intestine moistening.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.
Bulbus Allii Macrostemonis: acrid in the mouth; Bitter; Warm in nature.Cure mainly: the thorough back of the body of obstruction of qi in the chest and cardialgia; Breast gastral cavity painful abdominal mass is vexed; Cough with asthma abundant expectoration; Epigastric pain; Heavy after letting out dysentery; Leucorrhea; Furuncle carbuncle.
Radix Panacis Quinquefolii: sweet, micro-hardship is cool.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulability, in addition, diabetics is also had to the work regulating blood glucose.
Semen Vaccariae: bitter is flat.Promoting the circulation of blood is stimulated the menstrual flow, and expedites the emergence of stimulating milk secretion, detumescence sore.Control women's amenorrhea, galactostasis, difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.
Flos Carthami: irregular menstruation, puerperal abdonimal pain, lump in the abdomen, the diseases such as traumatic stasis swells and ache, ulcer sore pain.
Chinese medicine granules of the present invention is based on the principle of traditional Chinese medical herbal treatment nodules of the breast.The Chinese medicinal material selected all has blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons to promote blood circulation, effect of regulating the flow of Qi and the middle Jiao, and cheap, and life-time service also can not cause the financial burden of patient, is to treat the ideal medicine of nodules of the breast.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat a Chinese medicine granules for nodules of the breast, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams, Rhizoma Bolbostematis 10 grams, Fructus Crataegi 10 grams, Squama Manis 10 grams, Radix Rhapontici 20 grams, Radix Curcumae 20 grams, Rhizoma Curcumae 20 grams, Spina Gleditsiae 25 grams, Carapax Trionycis 25 grams, Fructus Trichosanthis 25 grams, Bulbus Allii Macrostemonis 25 grams, Radix Panacis Quinquefolii 30 grams, Semen Vaccariae 30 grams, 30 grams, Flos Carthami.
The preparation method of above-mentioned Chinese medicine granules, step is:
1. it is characterized in that: Fructus Crataegi, Squama Manis, Carapax Trionycis, Semen Vaccariae slow fire are fried 5 minutes, frying to drying in the air after giving out fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Panacis Quinquefolii, Flos Carthami, Spina Gleditsiae, Bulbus Allii Macrostemonis altogether pulverization cross 80 mesh sieves, must medicamental pulverata be mixed for subsequent use;
3. by Rhizoma Bolbostematis, Radix Rhapontici, Rhizoma Cyperi, Rhizoma Curcumae, Fructus Trichosanthis, decoct with water 2 times, decoct 2 hours, filter, obtain filtrate 1, filtering residue after filtration is added water and carries out second time decoction, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed with filtrate 2 and decocts 1 hour again, leave standstill 20 hours, again filter, obtain filtrate for subsequent use;
4. by step 2. in gained mixing medicamental pulverata pour into step 3. in gained filtrate in, mix homogeneously, standing cold preservation 30 hours, is concentrated into paste;
5. get appropriate Icing Sugar to dry 1 hour at 60 DEG C, be placed in container, add step 4. in gained paste thing stirring and evenly mixing, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 10 mesh sieves crossed by soft material, make wet granular;
6. wet granular bake drying step 5. made, dry temperature is 60 DEG C, namely obtains this Chinese medicine granules after cooling.
model case onepoplar XX, female, 27 years old, Chiping County, Liaocheng of Shandong Province, in June, 2012 falls ill, symptom: usually occur that stagnation of liver-QI is not relaxed, breast distension, caking distending pain with susceptible to anger growth and decline, time have twinge, two side of body distending pains, bitter taste is irritated, and pale tongue with thin fur is white, the symptom of stringy pulse.Sometimes also mood is unhappy, and sensation of pricking is more and more stronger, to such an extent as to is unwilling to speak and usually flies into a rage, start to take after learning this medicine, after taking 3 days, symptom starts to alleviate, and fully recovers when taking 7 days, after recovery from illness, edible Chinese medicine granules of the present invention consolidates 1 month again, and drug withdrawal is so far without recurrence.
embodiment 2treat a Chinese medicine granules for nodules of the breast, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 20 grams, Pseudobulbus Cremastrae Seu Pleiones 20 grams, Rhizoma Bolbostematis 20 grams, Fructus Crataegi 20 grams, Squama Manis 20 grams, Radix Rhapontici 30 grams, Radix Curcumae 30 grams, Rhizoma Curcumae 30 grams, Spina Gleditsiae 35 grams, Carapax Trionycis 35 grams, Fructus Trichosanthis 35 grams, Bulbus Allii Macrostemonis 35 grams, Radix Panacis Quinquefolii 40 grams, Semen Vaccariae 40 grams, 40 grams, Flos Carthami.
The preparation method of above-mentioned Chinese medicine granules, step is:
2. Fructus Crataegi, Squama Manis, Carapax Trionycis, Semen Vaccariae slow fire being fried 15 minutes, frying to drying in the air after giving out fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Panacis Quinquefolii, Flos Carthami, Spina Gleditsiae, Bulbus Allii Macrostemonis altogether pulverization cross 120 mesh sieves, must medicamental pulverata be mixed for subsequent use;
3. by Rhizoma Bolbostematis, Radix Rhapontici, Rhizoma Cyperi, Rhizoma Curcumae, Fructus Trichosanthis, decoct with water 2 times, decoct 2 hours, filter, obtain filtrate 1, filtering residue after filtration is added water and carries out second time decoction, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed with filtrate 2 and decocts 1 hour again, leave standstill 30 hours, again filter, obtain filtrate for subsequent use;
4. by step 2. in gained mixing medicamental pulverata pour into step 3. in gained filtrate in, mix homogeneously, standing cold preservation 30 hours, is concentrated into paste;
5. get appropriate Icing Sugar to dry 2 hours at 60 DEG C, be placed in container, add step 4. in gained paste thing stirring and evenly mixing, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 20 mesh sieves crossed by soft material, make wet granular;
6. wet granular bake drying step 5. made, dry temperature is 100 DEG C, namely obtains this Chinese medicine granules after cooling.
embodiment 3treat a Chinese medicine granules for nodules of the breast, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 13 grams, Pseudobulbus Cremastrae Seu Pleiones 13 grams, Rhizoma Bolbostematis 13 grams, Fructus Crataegi 13 grams, Squama Manis 13 grams, Radix Rhapontici 23 grams, Radix Curcumae 23 grams, Rhizoma Curcumae 23 grams, Spina Gleditsiae 28 grams, Carapax Trionycis 28 grams, Fructus Trichosanthis 28 grams, Bulbus Allii Macrostemonis 28 grams, Radix Panacis Quinquefolii 33 grams, Semen Vaccariae 33 grams, 33 grams, Flos Carthami.
The preparation method of above-mentioned Chinese medicine granules, step is:
3. Fructus Crataegi, Squama Manis, Carapax Trionycis, Semen Vaccariae slow fire being fried 8 minutes, frying to drying in the air after giving out fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Panacis Quinquefolii, Flos Carthami, Spina Gleditsiae, Bulbus Allii Macrostemonis altogether pulverization cross 90 mesh sieves, must medicamental pulverata be mixed for subsequent use;
3. by Rhizoma Bolbostematis, Radix Rhapontici, Rhizoma Cyperi, Rhizoma Curcumae, Fructus Trichosanthis, decoct with water 2 times, decoct 2 hours, filter, obtain filtrate 1, filtering residue after filtration is added water and carries out second time decoction, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed with filtrate 2 and decocts 1 hour again, leave standstill 23 hours, again filter, obtain filtrate for subsequent use;
4. by step 2. in gained mixing medicamental pulverata pour into step 3. in gained filtrate in, mix homogeneously, standing cold preservation 30 hours, is concentrated into paste;
5. get appropriate Icing Sugar to dry 1.3 hours at 60 DEG C, be placed in container, add step 4. in gained paste thing stirring and evenly mixing, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 13 mesh sieves crossed by soft material, make wet granular;
6. wet granular bake drying step 5. made, dry temperature is 70 DEG C, namely obtains this Chinese medicine granules after cooling.
embodiment 4treat a Chinese medicine granules for nodules of the breast, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 18 grams, Pseudobulbus Cremastrae Seu Pleiones 18 grams, Rhizoma Bolbostematis 18 grams, Fructus Crataegi 18 grams, Squama Manis 18 grams, Radix Rhapontici 28 grams, Radix Curcumae 28 grams, Rhizoma Curcumae 28 grams, Spina Gleditsiae 33 grams, Carapax Trionycis 33 grams, Fructus Trichosanthis 33 grams, Bulbus Allii Macrostemonis 33 grams, Radix Panacis Quinquefolii 38 grams, Semen Vaccariae 38 grams, 38 grams, Flos Carthami.
The preparation method of above-mentioned Chinese medicine granules, step is:
4. Fructus Crataegi, Squama Manis, Carapax Trionycis, Semen Vaccariae slow fire being fried 13 minutes, frying to drying in the air after giving out fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Panacis Quinquefolii, Flos Carthami, Spina Gleditsiae, Bulbus Allii Macrostemonis altogether pulverization cross 110 mesh sieves, must medicamental pulverata be mixed for subsequent use;
3. by Rhizoma Bolbostematis, Radix Rhapontici, Rhizoma Cyperi, Rhizoma Curcumae, Fructus Trichosanthis, decoct with water 2 times, decoct 2 hours, filter, obtain filtrate 1, filtering residue after filtration is added water and carries out second time decoction, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed with filtrate 2 and decocts 1 hour again, leave standstill 28 hours, again filter, obtain filtrate for subsequent use;
4. by step 2. in gained mixing medicamental pulverata pour into step 3. in gained filtrate in, mix homogeneously, standing cold preservation 30 hours, is concentrated into paste;
5. get appropriate Icing Sugar to dry 1.8 hours at 60 DEG C, be placed in container, add step 4. in gained paste thing stirring and evenly mixing, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 18 mesh sieves crossed by soft material, make wet granular;
6. wet granular bake drying step 5. made, dry temperature is 90 DEG C, namely obtains this Chinese medicine granules after cooling.
model case twoopen XX, female, 30 years old, Zhengzhou, henan people, in December, 2012 morbidity, symptom: breast lumps, dull pain or twinge, localized pain.Premenstrual lump obviously increases, through after reduce deliquescing, with menoxenia, dysmenorrhea etc. disease.Light red tongue tongue is white, and thready pulse moistens.The soreness of waist is weak, and through water is few, color is light, takes granule of the present invention 5 days recovery from illness, takes again 2 courses for the treatment of of granule of the present invention without recurrence after recovery from illness.
embodiment 5treat a Chinese medicine granules for nodules of the breast, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Cyperi 15 grams, Pseudobulbus Cremastrae Seu Pleiones 15 grams, Rhizoma Bolbostematis 15 grams, Fructus Crataegi 15 grams, Squama Manis 15 grams, Radix Rhapontici 25 grams, Radix Curcumae 25 grams, Rhizoma Curcumae 25 grams, Spina Gleditsiae 30 grams, Carapax Trionycis 30 grams, Fructus Trichosanthis 30 grams, Bulbus Allii Macrostemonis 30 grams, Radix Panacis Quinquefolii 35 grams, Semen Vaccariae 35 grams, 35 grams, Flos Carthami.
5. Fructus Crataegi, Squama Manis, Carapax Trionycis, Semen Vaccariae slow fire being fried 10 minutes, frying to drying in the air after giving out fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Panacis Quinquefolii, Flos Carthami, Spina Gleditsiae, Bulbus Allii Macrostemonis altogether pulverization cross 100 mesh sieves, must medicamental pulverata be mixed for subsequent use;
3. by Rhizoma Bolbostematis, Radix Rhapontici, Rhizoma Cyperi, Rhizoma Curcumae, Fructus Trichosanthis, decoct with water 2 times, decoct 2 hours, filter, obtain filtrate 1, filtering residue after filtration is added water and carries out second time decoction, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed with filtrate 2 and decocts 1 hour again, leave standstill 15 hours, again filter, obtain filtrate for subsequent use;
4. by step 2. in gained mixing medicamental pulverata pour into step 3. in gained filtrate in, mix homogeneously, standing cold preservation 30 hours, is concentrated into paste;
5. get appropriate Icing Sugar to dry 1.5 hours at 60 DEG C, be placed in container, add step 4. in gained paste thing stirring and evenly mixing, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 15 mesh sieves crossed by soft material, make wet granular;
6. wet granular bake drying step 5. made, dry temperature is 80 DEG C, namely obtains this Chinese medicine granules after cooling.
Using method: for making the present invention reach optimum therapeuticing effect, time edible, takes after 1 hour after the meal, with warm boiled water, and 3 times on the one, each 10 grams.
experimental exampleobject is to verify whether this Chinese medicine granules has curative effect to treatment nodules of the breast.
" new Chinese medicine guideline of clinical investigations " according to Ministry of Public Health formulation in 1993 is diagnosis basis, and totally 200 routine nodules of the breast patients, the mean age is 30 years old.Random division is administration group and matched group.
Before the experiments one day, record patient health, look over patient body symptom every day, guarantee administration group and matched group situation basically identical.Administration group eats this product embodiments 5 gained Chinese medicine granules every day, within 7 days, is a course for the treatment of.Check patient body situation every day, make a record.Result is as following table 1:
Table 1:
efficacy analysis:when administration group (Chinese medicine granules of the present invention) uses 7 days, most patient sensory symptoms obviously alleviates, and obviously feels to take a favorable turn in affected part, and patient's emotion takes a turn for the better, and during medication 10 days, patient is almost recovered, and drug withdrawal a period of time has no repeatedly, and the state of an illness is better controlled.Matched group take medicine after curative effect obvious, but after drug withdrawal, the patient of 94% is recurred again.
Prove through clinical trial, Chinese medicine granules of the present invention is on treatment nodules of the breast, and effective percentage is 98%, and cure rate is 95%, exceeds 28% than oral western medicine effective percentage, and cure rate exceeds 20%, and thoroughly can remove old complaint, makes the recovery from illness that patient is real; And any burden can not be caused to the health of patient.Chinese medicine granules instant effect of the present invention, can reach the object alleviating rapidly patient's misery, and relapse rate is low, is a kind of Chinese medicine granules for the treatment of nodules of the breast safely and effectively.
Claims (7)
1. treat a Chinese medicine granules for nodules of the breast, it is characterized in that: take off the raw material stating weight proportion: Rhizoma Cyperi 10 parts, Pseudobulbus Cremastrae Seu Pleiones 10 parts, Rhizoma Bolbostematis 10 parts, Fructus Crataegi 10 parts, Squama Manis 10 parts, Radix Rhapontici 20 parts, Radix Curcumae 20 parts, Rhizoma Curcumae 20 parts, Spina Gleditsiae 25 parts, Carapax Trionycis 25 parts, Fructus Trichosanthis 25 parts, Bulbus Allii Macrostemonis 25 parts, Radix Panacis Quinquefolii 30 parts, Semen Vaccariae 30 parts, 30 parts, Flos Carthami; Preparation method step is as follows:
1. Fructus Crataegi, Squama Manis, Carapax Trionycis, Semen Vaccariae slow fire being fried 5-15 minute, frying to drying in the air after giving out fragrance cool, take out dry stand-by;
2. by step 1. gains and Radix Curcumae, Pseudobulbus Cremastrae Seu Pleiones, Radix Panacis Quinquefolii, Flos Carthami, Spina Gleditsiae, Bulbus Allii Macrostemonis altogether pulverization cross 80-120 mesh sieve, must medicamental pulverata be mixed for subsequent use;
3. by Rhizoma Bolbostematis, Radix Rhapontici, Rhizoma Cyperi, Rhizoma Curcumae, Fructus Trichosanthis, decoct with water 2 times, first time decocts 2 hours, filters, obtain filtrate 1, filtering residue after filtration is added water and carries out second time decoction, decoct 1.5 hours, obtain filtrate 2, filtrate 1 is mixed with filtrate 2 and decocts 1 hour again, leave standstill 20-30 hour, again filter, obtain filtrate for subsequent use;
4. by step 2. in gained mixing medicamental pulverata pour into step 3. in gained filtrate in, mix homogeneously, standing cold preservation 30 hours, is concentrated into paste;
5. get appropriate Icing Sugar and dry 1-2 hour at 60 DEG C, be placed in container, add step 4. in gained paste thing stirring and evenly mixing, being modulated into soft durometer is the soft material that hands is pinched agglomerating light pressure and then fallen apart, and 10-20 mesh sieve crossed by soft material, makes wet granular;
6. wet granular bake drying step 5. made, dry temperature is 60-100 DEG C, namely obtains this Chinese medicine granules after cooling.
2. Chinese medicine granules according to claim 1, is characterized in that: step 1. slow fire fries 8-13 minute.
3. Chinese medicine granules according to claim 1, is characterized in that: 2. step crosses 90-110 mesh sieve.
4. Chinese medicine granules according to claim 1, is characterized in that: 3. step leaves standstill 23-28 hour.
5. Chinese medicine granules according to claim 1, is characterized in that: 5. step dries 1.3-1.8 hour.
6. Chinese medicine granules according to claim 1, is characterized in that: 5. step crosses 13-18 mesh sieve.
7. Chinese medicine granules according to claim 1, is characterized in that: step 6. baking temperature is 70-90 DEG C.
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