WO2015149392A1 - Preparation of traditional chinese medicine for treating chronic colitis and preparation method therefor - Google Patents

Preparation of traditional chinese medicine for treating chronic colitis and preparation method therefor Download PDF

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WO2015149392A1
WO2015149392A1 PCT/CN2014/075339 CN2014075339W WO2015149392A1 WO 2015149392 A1 WO2015149392 A1 WO 2015149392A1 CN 2014075339 W CN2014075339 W CN 2014075339W WO 2015149392 A1 WO2015149392 A1 WO 2015149392A1
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preparation
asparagus
chinese medicine
licorice
traditional chinese
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PCT/CN2014/075339
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袁志贤
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袁志贤
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system

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  • the invention relates to a traditional Chinese medicine preparation for treating colitis, in particular to a traditional Chinese medicine preparation for treating chronic colitis and a preparation method thereof.
  • the intestine refers to the digestive tract from the pylorus of the stomach to the anus.
  • the intestine is the longest part of the digestive tract and the most important part of the function.
  • the intestine is the largest digestive organ of the human body and the largest detoxification organ in the human body. From the perspective of physiology, anatomy, and cytology, large intestine detoxification accounts for more than 85 % of human detoxification; 80% of the human body's immune structure is around the intestine, and endotoxin accumulation is the killer of autoimmune immunity.
  • Chronic colitis is a common disease. Clinical manifestations include increased frequency of stools, no grain, or watery or sticky, accompanied by bowel, abdominal pain, and even spleen and kidney.
  • the general disease is in the intestine, but it involves the spleen, stomach, liver, kidney and other organs. It will be thin and burnout for a long time.
  • This card is one of the common spleen and stomach diseases in the clinic. It has a high incidence rate, easy recurrence, and lingering, which seriously affects people's normal life, and the cancer rate is about 5%.
  • the object of the present invention is to provide a traditional Chinese medicine preparation for treating chronic colitis based on the above-mentioned deficiencies, combined with modern Chinese and Western medicine technology, and in particular to provide such a traditional Chinese medicine preparation and a preparation method thereof, the present invention
  • the treatment of colitis is obvious, and it is non-toxic, has no side effects, and has stable effects.
  • the preparation process is simple and easy.
  • the preparation of the invention is from Magnolia officinalis, Poria, Evodia, Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Rhubarb, Radix Paeoniae Alba, Bergamot, Yam, Chuanxiongzi, Jiangxiang, Jatropha, Asparagus, Skull, Pinellia, Yanhusuo, Shengdi And a preparation of a composition prepared from red dates, wherein the mass ratio of each component is: Magnolia 12-20g ⁇ 10-22g Wu Wei
  • the preferred raw materials of the present invention is: Magnolia 12-18g ⁇ 10-18g Wujing 8-12g Astragalus 12-18g Licorice 8-12g Sanqi 10-15g Rhubarb 8-12g White peony 12-16g bergamot 8-12g yam 10-15g medlar 10-14g 10-15g
  • the present invention is also preferable to the raw material of Magnolia 15g ⁇ 12g Wujing 9g Astragalus 15g Licorice 10g Sanqi 12g Rhubarb 12g White peony 10g Bergamot 8g Yam 12g Chuanxiong 14g Fragrance 12g Iris 8g asparagus 8g thief bone 12g pinellia 10g yanhusuo 8g habitat 10g jujube 15g c
  • the above preparation method for treating a chronic colitis traditional Chinese medicine preparation comprises the following steps:
  • step 3 mix the powders of each component in step 1) and 2), add boiling water twice, add 10 times pure water for 1 hour, extract the filtrate for use; 6 times pure water decoction for half an hour, then combine the decoction and filter, spare; 4), the remaining Sanqi, Yam, Chuanxiongzi, Jiangxiang, Iris, asparagus, ribs, and raw land are proportioned well, crushed into powder by a pulverizer and passed through a 80 mesh sieve, and dried naturally. spare;
  • step 5 mixing the powders of each component in step 4), adding 4 to 6 times 70% ⁇ 80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
  • the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to 3) the combined decoction in the step, and the mixture is shaken to obtain.
  • the prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening, and it is used for a long time, the effect is better.
  • the theoretical basis of the present invention is: Magnolia, a medicinal plant belonging to the family Magnoliaceae, and the growth region is mainly in Sichuan, Hubei and the like. Indications of food stagnation, abdominal distension constipation, wet resistance in the coke, vomiting and diarrhea, suffocating, chest full of asthma and cough and other symptoms. It has the effects of stagnation of phlegm and blood stasis, qi and asthma, phlegm and phlegm, and dispelling wind and analgesia.
  • Decoction has a broad-spectrum antibacterial effect, inhibiting Staphylococcus aureus, hemolytic streptococcus, diphtheria bacilli in vitro; in addition, Magnolia also regulates smooth muscle, anti-ulcer, central inhibition, blood pressure lowering, anti-pathogenic microorganisms , anti-tumor and other effects.
  • sweet, light, flat, medicine has the benefit of water and moisture, spleen and stomach, Ningxin and soothe the nerves, attending urinary unfavorable, edema full, sputum cough, vomiting, modern medical research: ⁇ can enhance the body The immune function, ⁇ polysaccharide has obvious anti-tumor and liver-preserving effects.
  • Wu Hao hot taste, bitter taste, Xin
  • the Scriptures records Wu Hao: “Main temperature in the air, pain, cough, cold, heat, dehumidification, blood stasis, wind and evil, Kai Lili.”
  • Compendium of Materia Medica records Wu Hao: “Open stagnation, cure phlegm, phlegm and phlegm, headache, yin and stomach pain, phlegm and blood stasis, mouth sore mouth. "There are cold and pain relief, lowering vomiting, used to treat liver and stomach deficiency, yin Headache or stomach cramps caused by turbidity.
  • Astragalus membranaceus has the benefits of qi and sun, solid table antiperspirant, diuretic swelling, detoxification and myogenic effects. Indications for all qi deficiency and blood loss, such as spleen deficiency diarrhea, lung deficiency cough, rectal prolapse, uterine ptosis, spontaneous sweating, night sweats, edema, blood stasis, sputum is difficult to collapse or long-term collapse.
  • Licorice a kind of tonic Chinese herbal medicine, the medicinal parts are roots and rhizomes.
  • the roots of the medicinal properties are cylindrical, with spleen and qi, clearing away heat and detoxification, relieving cough, relieving pain, reconciling the effects of various medicines; Weary fatigue, palpitations, shortness of breath, coughing, abdominal pain, sudden pain in the limbs, swollen sores, relieve drug toxicity, potency and so on. Sanqi, used to stop bleeding and dilated blood, reduce swelling and pain.
  • yin deficiency fever dry lung cough, fatigue cough, Tianjin wound thirst, upset insomnia, internal heat and thirst, intestinal dry constipation, lung sputum, lung sputum, diphtheria and other symptoms; inhibition of a variety of bacteria, anti- Tumor activity, can nourish yin and spleen, moisten the lungs and clear the heart, remove dryness and reduce fire.
  • Cuttlefish bone containing calcium carbonate, can neutralize stomach acid, relieve symptoms of vomiting and heartburn, promote inflammation of the ulcer surface, prevent bleeding, relieve local pain. It can be used as an antacid.
  • Corydalis, temperature, taste, bitterness, liver, spleen, stomach, is a wonderful product of promoting blood circulation, relieving pain and relieving pain, especially known for its anti-pain effect.
  • the curative effect is remarkable.
  • Jujube, jujube is warm and sweet, contains protein, fat, sugar, calcium, phosphorus, iron, magnesium and rich vitamins.
  • the oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses of treatment as therapeutic effects.
  • the oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses for observation of curative effect.
  • the beneficial effects of the present invention are that the preparation prepared by the present invention is for treatment Chronic colitis has good effects, and it is non-toxic, has no side effects, and has a stable effect.
  • the preparation process is simple and easy. Concrete real
  • the preparation of the invention is from Magnolia officinalis, Poria, Evodia, Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Rhubarb, Radix Paeoniae Alba, Bergamot, Yam, Chuanxiongzi, Jiangxiang, Jatropha, Asparagus, Skull, Pinellia, Yanhusuo, Shengdi And the preparation of the composition prepared by the red jujube, wherein the mass ratio of each component is: Magnolia 12g ⁇ 10g Wujing 10g Astragalus 12g Licorice 12g Sanqi 15g Rhubarb 10g White Pelican 12g Bergamot 8g Yam 15g Chuanxiong 15g Fragrance 13g Festival Iris 12g asparagus 8g thief bone 10g Pinellia 12g Yanhusuo 13g soil 10g jujube 16g.
  • the preparation method of the traditional Chinese medicine preparation for treating chronic colitis includes the following steps: 1) placing the cockroach into a small pot for small frying until the surface is slightly coke, and then pulverizing through a pulverizer and passing through a 80 mesh sieve for use; 2), the magnolia, Wujing, Astragalus, licorice, rhubarb, white peony, bergamot, red dates, pinellia, yanhusuo are proportioned well, pulverized into powder after crushing machine and passed through a 90 mesh sieve, naturally dried, ready for use;
  • step 5 mixing the powders of each component in step 4), adding 4 to 6 times 70% ⁇ 80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
  • the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to the combined decoction in the step 3), and mixed and shaken to obtain.
  • the preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.
  • the preferred raw material quality of the present invention is (g):
  • the preparation method is as in Example 1.

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Abstract

Preparation of traditional Chinese medicine for treating chronic colitis and preparation method therefor, comprising Magnolia officinalis, Wolfiporia extensa, Tetradium ruticarpum, Astragalus propinquus, licorice, Panax notoginseng, Rheum rhabarbarum, Paeonia lactiflora, Citrus medica sarcodactylis, Dioscorea opposita, Melia toosendan, Dalbergia odorifera, Rhizoma Anemones Altaicae, Asparagus cochinchinensis, cuttlebone, Pinellia ternata, Corydalis yanhusuo, Radix Rehmanniae, and jujube, said ingredients being subjected to processes of powdering, decoction, ethanol extraction and mixing into a composition for liquid preparations.

Description

一种治疗慢性结肠炎的中药制剂及其制备方法 技术领域  Traditional Chinese medicine preparation for treating chronic colitis and preparation method thereof
本发明涉及一种治疗结肠炎的中药制剂,具体涉及一种治疗慢性 结肠炎的中药制剂及其制备方法。 背景技术  The invention relates to a traditional Chinese medicine preparation for treating colitis, in particular to a traditional Chinese medicine preparation for treating chronic colitis and a preparation method thereof. Background technique
肠道指的是从胃幽门至肛门的消化管,肠道是消化管中最长的一 段, 也是功能最重要的一段。 肠道是人体最大的消化器官, 也是人体 最大的排毒器官。 从生理学、 解剖学、 细胞学的角度来看, 大肠排毒 占人体排毒的 85 %以上; 人体的 80 %免疫结构在肠道周围, 内毒素的 堆积是自体免疫力的杀手。  The intestine refers to the digestive tract from the pylorus of the stomach to the anus. The intestine is the longest part of the digestive tract and the most important part of the function. The intestine is the largest digestive organ of the human body and the largest detoxification organ in the human body. From the perspective of physiology, anatomy, and cytology, large intestine detoxification accounts for more than 85 % of human detoxification; 80% of the human body's immune structure is around the intestine, and endotoxin accumulation is the killer of autoimmune immunity.
慢性结肠炎是一种常见疾病, 临床多表现为大便次数增多、五谷 不化、或如水样或黏滞,伴有肠鸣、腹痛,甚者脾肾俱虚,五更而泄。 一般病位在肠,但是累及脾、 胃、肝、肾等脏腑, 日久则消瘦、倦怠。 此证为临床常见脾胃病之一, 发病率高, 易反复发作, 缠绵难愈, 严 重影响着人们的正常生活, 且日久癌变率达 5 %左右。 尽管目前用于 治疗结肠炎的药物不算少, 但西药治标不治本, 用久了容易产生抗药 性, 副作用比较大, 损害肝脏、 肾脏及血细胞, 而且药效不稳定, 容 易反复发作。 发明内容 本发明的目的即在于针对上述不足, 在祖传秘方的基础上, 结合 现代中西医技术, 提供一种治疗慢性结肠炎的中药制剂, 具体的说是 提供这种中药制剂及其制备方法, 本发明结肠炎治疗效果明显, 而且 无毒, 无副作用, 效果稳定, 制取工艺简便易行。 Chronic colitis is a common disease. Clinical manifestations include increased frequency of stools, no grain, or watery or sticky, accompanied by bowel, abdominal pain, and even spleen and kidney. The general disease is in the intestine, but it involves the spleen, stomach, liver, kidney and other organs. It will be thin and burnout for a long time. This card is one of the common spleen and stomach diseases in the clinic. It has a high incidence rate, easy recurrence, and lingering, which seriously affects people's normal life, and the cancer rate is about 5%. Although the drugs currently used to treat colitis are not small, the Western medicine is not a cure for the symptoms, it is easy to produce drug resistance for a long time, the side effects are relatively large, the liver, kidney and blood cells are damaged, and the drug effect is unstable, and it is easy to recur. Summary of the invention The object of the present invention is to provide a traditional Chinese medicine preparation for treating chronic colitis based on the above-mentioned deficiencies, combined with modern Chinese and Western medicine technology, and in particular to provide such a traditional Chinese medicine preparation and a preparation method thereof, the present invention The treatment of colitis is obvious, and it is non-toxic, has no side effects, and has stable effects. The preparation process is simple and easy.
本发明的技术方案如下所述:  The technical solution of the present invention is as follows:
本发明制剂是由厚朴、茯苓、吴茱萸、黄芪、甘草、三七、大黄、 白芍、 佛手、 山药、 川楝子、 降香、 节菖蒲、 天冬、 贼骨、 半夏、 延 胡索、 生地和红枣制备成的组合物制剂, 其中各组分的质量配比为: 厚朴 12-20g 苓 10-22g 吴茱萸 The preparation of the invention is from Magnolia officinalis, Poria, Evodia, Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Rhubarb, Radix Paeoniae Alba, Bergamot, Yam, Chuanxiongzi, Jiangxiang, Jatropha, Asparagus, Skull, Pinellia, Yanhusuo, Shengdi And a preparation of a composition prepared from red dates, wherein the mass ratio of each component is: Magnolia 12-20g 苓10-22g Wu Wei
8-18g 8-18g
黄芪 10-18g 甘草 8-15g 三七 10-20g 大黄 8-16g 白芍 12-20g 佛手 8-16g 山药 10-18g 川楝子 l()-18g 降香 Astragalus 10-18g Licorice 8-15g Sanqi 10-20g Rhubarb 8-16g White Pelican 12-20g Bergamot 8-16g Yam 10-18g Chuanxiong l()-18g Fragrance
10- 18g 10- 18g
节菖蒲 8-15g 天冬 6-15g 贼骨 8-15g 半夏 10-18g 延胡索 8-16g 生地 8-15g 红枣 10-20g。  Iris calyx 8-15g asparagus 6-15g thief bone 8-15g pinellia 10-18g yanhusuo 8-16g raw land 8-15g red dates 10-20g.
为了获得更好的效果: 本发明可优选的原料质: :配比为: 厚朴 12-18g 茯苓 10-18g 吴茱萸 8-12g 黄芪 12-18g 甘草 8-12g 三七 10-15g 大黄 8-12g 白芍 12-16g 佛手 8-12g 山药 10-15g 楝子 10-14g 降香 10-15g In order to obtain better results: The preferred raw materials of the present invention: The ratio is: Magnolia 12-18g 茯苓10-18g Wujing 8-12g Astragalus 12-18g Licorice 8-12g Sanqi 10-15g Rhubarb 8-12g White peony 12-16g bergamot 8-12g yam 10-15g medlar 10-14g 10-15g
节菖蒲 8-12g 天冬 6- 贼骨 8-12g 半夏 10-15g 延胡索 生地 8-12g 红枣 12-18g。  Iris sinensis 8-12g Asparagus 6- thief bone 8-12g Pinellia 10-15g Yanhusuo habitat 8-12g red dates 12-18g.
当然, 为了获得进一歩好的效果, 本发明还可优选的原料质 厚朴 15g 茯苓 12g 吴茱萸 9g 黄芪 15g 甘草 10g 三七 12g 大黄 12g 白芍 10g 佛手 8g 山药 12g 川楝子 14g 降香 12g 节菖蒲 8g 天冬 8g 贼骨 12g 半夏 10g 延胡索 8g 生地 10g 红枣 15gc Of course, in order to obtain a good effect, the present invention is also preferable to the raw material of Magnolia 15g 茯苓12g Wujing 9g Astragalus 15g Licorice 10g Sanqi 12g Rhubarb 12g White peony 10g Bergamot 8g Yam 12g Chuanxiong 14g Fragrance 12g Iris 8g asparagus 8g thief bone 12g pinellia 10g yanhusuo 8g habitat 10g jujube 15g c
上述治疗慢性结肠炎中药制剂的制备方法, 包括如下歩骤: The above preparation method for treating a chronic colitis traditional Chinese medicine preparation comprises the following steps:
1 )、将茯苓放入小锅进行小炒至表面微焦, 然后经粉碎机粉碎并 过 80目筛, 备用; 1), put the cockroach into a small pot and stir fry until the surface is slightly coke, then crush it through the pulverizer and pass through the 80 mesh sieve, and set aside;
2 )、 将厚朴、 吴茱萸、 黄芪、 甘草、 大黄、 白芍、 佛手、 红枣、 半夏、 延胡索按比例配好, 经过粉碎机粉碎成粉末并过 90 目筛, 自 然晾干, 备用;  2), the Magnolia, Wujing, Astragalus, Licorice, Rhubarb, Angelica, Bergamot, Jujube, Pinellia, and Corydalis are proportioned well, crushed into powder by a pulverizer and passed through a 90 mesh sieve, and dried naturally for use;
3 )、 将歩骤 1 ) 和 2 ) 中的各组分粉末混合在一起, 加入纯净水 煎煮两次, 第一次加入 10倍纯净水煎煮 1小时, 提取滤液备用; 第 二次加入 6倍纯净水煎煮半小时, 然后合并煎液并过滤, 备用; 4 )、将剩下的三七、 山药、川楝子、 降香、节菖蒲、天冬、贼骨、 生地按比例配好, 经过粉碎机粉碎成粉末并过 80 目筛, 自然晾干, 备用; 3), mix the powders of each component in step 1) and 2), add boiling water twice, add 10 times pure water for 1 hour, extract the filtrate for use; 6 times pure water decoction for half an hour, then combine the decoction and filter, spare; 4), the remaining Sanqi, Yam, Chuanxiongzi, Jiangxiang, Iris, asparagus, ribs, and raw land are proportioned well, crushed into powder by a pulverizer and passed through a 80 mesh sieve, and dried naturally. spare;
5 )、 将歩骤 4 ) 中各组分粉末混合在一起, 加入 4〜6倍70%〜80% 的乙醇, 加热回流 3〜5个小时, 提取过滤获得滤液; 然后在剩下的药 渣中再次加入 2〜4倍65%〜75%的乙醇, 加热回流 2〜3个小时, 提取过 滤获得滤液;将两次获得的滤液合并在一起,减压浓缩除去乙醇溶剂, 干燥, 获得干膏;  5), mixing the powders of each component in step 4), adding 4 to 6 times 70%~80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
6 )、 将上述歩骤 5 ) 中获得的干膏进行超微粉碎成粉末并过 200 目筛, 然后将粉末加入 3 ) 歩骤中的合并煎液, 混合摇匀即可制得。  6), the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to 3) the combined decoction in the step, and the mixture is shaken to obtain.
制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚 各适量饮用一次并长期饮用, 效果更好。 本发明的理论依据在于: 厚朴, 是一种属于木兰科的药用植物, 生长区域主要在四川、 湖 北等地。主治食积气滞,腹胀便秘,湿阻中焦,脘痞吐泻,痰壅气逆, 胸满喘咳等症状。有化湿导滞、行气平喘、化食消痰、驱风镇痛之效; 厚朴反射性的引起唾液、 胃液分泌、 胃肠蠕动加快, 而有健胃助消化 的作用; 厚朴煎剂有广谱抗菌作用, 体外对金黄色葡萄球菌、 溶血性 链球菌、 白喉杆菌等均有抑制作用; 另外, 厚朴还有调节平滑肌、 抗 溃疡、 中枢抑制、 降血压、 抗病原微生物、 抗肿瘤等作用。 茯苓, 味甘、 淡, 性平, 入药具有利水渗湿、 益脾和胃、 宁心安 神之功用, 主治小便不利, 水肿胀满, 痰饮咳逆、 呕吐, 现代医学研 究: 茯苓能增强机体免疫功能, 茯苓多糖有明显的抗肿瘤及保肝脏作 用。 吴茱萸, 性味热, 味道苦、 辛, 《本经》记载吴茱萸: "主温中 下气, 止痛, 咳逆寒热, 除湿, 血痹, 逐风邪, 开腠理。 " 《本草纲 目》 记载吴茱萸: "开郁化滞, 治吞酸, 厥阴痰涎头痛, 阴毒腹痛, 疝气血痢, 喉舌口疮。 "有散寒止痛、 降逆止呕之功, 用于治疗肝胃 虚寒、 阴浊上逆所致的头痛或胃脘疼痛等症。 黄芪, 具有益气升阳, 固表止汗, 利水消肿, 脱毒生肌等功效。 主治一切气虚血亏之证, 如脾虚泄泻, 肺虚咳嗽, 脱肛, 子宫下垂, 自汗, 盗汗, 水肿, 血痹, 痈疽难溃或久溃不敛。 甘草, 是一种补益中草药, 药用部位是根及根茎, 药材性状根呈 圆柱形, 具有补脾益气, 清热解毒, 祛痰止咳, 缓急止痛, 调和诸药 的作用; 用于脾胃虚弱, 倦怠乏力, 心悸气短, 咳嗽痰多, 脘腹、 四 肢挛急疼痛, 痈肿疮毒, 缓解药物毒性、 烈性等。 三七,用于止血散瘀, 消肿定痛。主治吐血, 咳血,尿血,便血, 血痢,崩漏,产后出血,外伤出血,跌扑损伤, 胸痹心痛,脘胁久痛, 癥瘕积块, 血瘀经闭, 痛经, 产后瘀滞腹痛, 疮痈肿痛; 与本发明其 他中药配伍, 治疗结肠炎效果明显。 大黄, 味苦, 性寒, 归胃、 脾、 大肠、 肝、 心包经, 能够泻热通 肠, 逐瘀通经, 凉血解毒。 用于瘀血经闭, 跌打损伤, 湿热黄疸, 血 热吐衄, 实热便秘, 积滞腹痛, 肠痈腹痛, 泻痢不爽, 目赤, 咽肿, 痈肿疔疮, 外治水火烫伤;上消化道出血。 用于血热有瘀出血者, 主 治急性胃、 十二指肠溃疡合并出血。 白芍, 味苦, 酸, 微寒, 归肝经。 养血和营, 缓急止痛, 敛阴平 肝。 主治血虚寒热, 脘腹疼痛, 胁痛, 肢体痉挛疼痛, 通经, 月经不 调, 崩漏, 自汗, 盗汗, 下痢泄泻, 头痛眩暈。 佛手, 味苦、 辛、 甘, 性温、 无毒, 入肝、 脾、 胃三经, 有疏肝 理气, 和胃肠止痛的功效, 用于肝胃气滞, 胃脘痞满, 食少呕吐, 对 肠管平滑肌有明显的抑制作用, 对肠痉挛有解痉作用; 有扩张冠狀血 管, 增加冠脉流量的作用; 高浓度时能减弱心肌收缩力, 减慢心率, 降低血压, 以保护心肌缺血; 有一定的祛痰作用。 山药, 味甘, 性凉润, 入肺、 脾、 肾经, 含有淀粉酶、 多酚氧化 酶等物质, 有利于脾胃消化吸收功能, 是一味平补脾胃的药食两用之 品。 不论脾阳亏或胃阴虚, 皆可食用。 临床上常与胃肠饮同用治脾胃 虚弱、 食少体倦、 泄泻等病症。 补脾, 养肺, 固肾, 益精; 主治脾虚 泄泻, 食少浮肿, 肺虚咳喘, 消渴, 遗精, 带下, 肾虚尿频。 川楝子, 性味苦, 寒; 有小毒, 归肝、 小肠、 膀胱经。 舒肝行气 止痛, 驱虫。 用于胸胁、 脘腹胀痛, 疝痛, 虫积腹痛。 降香, 性辛、 温, 归肝、 脾经。 行气活血, 止痛, 止血。 用于脘 腹疼痛, 肝郁胁痛, 胸痹剌痛, 跌扑损伤, 外伤出血; 以及寒疝疼痛 或秽浊内阻之呕吐腹痛。 节菖蒲, 性味辛, 微温、无毒; 归心、肝、脾经, 具有化痰开窍, 安神, 宣湿醒脾, 解毒的功效; 主热病神昏, 癫痫, 气闭耳聋, 多梦 健忘, 胸闷腹胀, 食欲不振, 风湿痹痛, 痈疽, 疥癣等症。 天冬, 性味: 甘、 苦, 寒; 归肺、 肾经。 用于阴虚发热、 肺燥干 咳、 虚劳咳嗽、 津伤口渴、 心烦失眠、 内热消渴、 肠燥便秘、 肺痿、 肺痈、 白喉等症状; 对多种细菌有抑制作用, 有抗肿瘤活性, 能养阴 生津、 润肺清心、 除燥降火。 乌贼骨, 含有碳酸钙, 可中和胃酸, 缓解呕酸及烧心症状, 又可 促进溃疡面炎症吸收, 阻止出血, 减轻局部疼痛. 故可作制酸剂. 实 验表明: 其复方制剂乌贝散有明显吸附胃蛋白酶及中和胃酸的作用, 可减少胃酸对胃溃疡面的剌激, 亦减少蛋白酶对溃疡面的消化作用, 以此有利于肠胃。 半夏, 性味辛, 温, 有毒。 归脾、 胃、 肺经。 具有燥湿化痰, 降 逆止呕, 消痞散结等功效; 主治咳喘痰多, 呕吐反胃, 胸脘痞满, 头 痛眩暈, 夜卧不安, 瘿瘤痰核, 痈疽肿毒等症。 延胡索, 性温, 味辛、 苦, 归肝、 脾、 胃经, 是活血化瘀、 行气 止痛之妙品, 尤以止痛之功效而著称于世。 主治胸胁, 脘腹疼痛, 经 闭痛经, 产后瘀阻, 跌扑肿痛。 生地, 味甘、苦, 性寒; 归心、肝、肺经。凉血清热、滋阴补肾、 生津止渴, 常用于治疗骨蒸痨热、 咽喉燥痛、 痰中带血等症。 和本发 明其他中药配伍, 疗效显著。 红枣, 红枣性温味甘, 含有蛋白质、 脂肪、 糖、 钙、 磷、 铁、 镁 及丰富的维生素, 此外还含有胡萝卜素等, 营养十分丰富, 有补脾、 养血、 安神作用, 补血调经, 活血止痛, 润肠通便的功能, 具有润肺 健脾、 止咳、 补五脏、 疗虚损的作用。 从我国传统中医角度讲, 慢性结肠炎中医辨病属 "泄泻" 、 "白 痢"等范畴。 临床症状以慢性腹泻、 腹痛, 排黏液便、 血便为主, 呈 慢性反复性发作或持续性发作, 本病病程较长, 多因长期饮食不慎、 劳倦内伤, 致脾胃虚弱, 因此通过本发明上述中药配伍以及制备方法 获得的组合物,采用辩证的方法有效的达到调理肠道与五脏六腑的功 效, 无毒副作用, 效果稳定, 与西药相比达到事半功倍的疗效。 临床实验 1: The prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening, and it is used for a long time, the effect is better. The theoretical basis of the present invention is: Magnolia, a medicinal plant belonging to the family Magnoliaceae, and the growth region is mainly in Sichuan, Hubei and the like. Indications of food stagnation, abdominal distension constipation, wet resistance in the coke, vomiting and diarrhea, suffocating, chest full of asthma and cough and other symptoms. It has the effects of stagnation of phlegm and blood stasis, qi and asthma, phlegm and phlegm, and dispelling wind and analgesia. The reflection of saliva, gastric juice, gastrointestinal motility is accelerated, and there is a stomach to help digestion; Decoction has a broad-spectrum antibacterial effect, inhibiting Staphylococcus aureus, hemolytic streptococcus, diphtheria bacilli in vitro; in addition, Magnolia also regulates smooth muscle, anti-ulcer, central inhibition, blood pressure lowering, anti-pathogenic microorganisms , anti-tumor and other effects. 茯苓, sweet, light, flat, medicine has the benefit of water and moisture, spleen and stomach, Ningxin and soothe the nerves, attending urinary unfavorable, edema full, sputum cough, vomiting, modern medical research: 茯苓 can enhance the body The immune function, 茯苓 polysaccharide has obvious anti-tumor and liver-preserving effects. Wu Hao, hot taste, bitter taste, Xin, "The Scriptures" records Wu Hao: "Main temperature in the air, pain, cough, cold, heat, dehumidification, blood stasis, wind and evil, Kai Lili.""Compendium of Materia Medica" records Wu Hao: "Open stagnation, cure phlegm, phlegm and phlegm, headache, yin and stomach pain, phlegm and blood stasis, mouth sore mouth. "There are cold and pain relief, lowering vomiting, used to treat liver and stomach deficiency, yin Headache or stomach cramps caused by turbidity. Astragalus membranaceus, has the benefits of qi and sun, solid table antiperspirant, diuretic swelling, detoxification and myogenic effects. Indications for all qi deficiency and blood loss, such as spleen deficiency diarrhea, lung deficiency cough, rectal prolapse, uterine ptosis, spontaneous sweating, night sweats, edema, blood stasis, sputum is difficult to collapse or long-term collapse. Licorice, a kind of tonic Chinese herbal medicine, the medicinal parts are roots and rhizomes. The roots of the medicinal properties are cylindrical, with spleen and qi, clearing away heat and detoxification, relieving cough, relieving pain, reconciling the effects of various medicines; Weary fatigue, palpitations, shortness of breath, coughing, abdominal pain, sudden pain in the limbs, swollen sores, relieve drug toxicity, potency and so on. Sanqi, used to stop bleeding and dilated blood, reduce swelling and pain. Indications of vomiting blood, hemoptysis, hematuria, blood in the stool, blood stasis, uterine bleeding, postpartum hemorrhage, traumatic bleeding, falling and damaging, chest pain, heartache, chronic pain, syndrome, blood stasis, dysmenorrhea, postpartum stagnation Abdominal pain, sore throat and swelling; combined with other Chinese medicines of the invention, the effect of treating colitis is obvious. Rhubarb, bitter taste, cold, return to the stomach, spleen, large intestine, liver, pericardium, can diarrhea heat the intestines, pass through the phlegm, cool blood detoxification. For blood stasis, bruises, damp heat jaundice, blood heat spitting, real heat constipation, stagnation of abdominal pain, intestinal cramps, abdominal pain, diarrhea, redness, pharyngeal swelling, hemorrhoids, external hemorrhoids Upper gastrointestinal bleeding. For patients with blood stasis and bleeding, attending acute stomach, duodenal ulcer combined with bleeding. White peony, bitter taste, sour, slightly cold, return to the liver. Nourishing blood and camp, relieve pain and relieve pain, and calm the liver. Indications of blood deficiency and cold, abdominal pain, hypochondriac pain, limb pain, menstruation, irregular menstruation, uterine bleeding, spontaneous sweating, night sweats, diarrhea, headache, dizziness. Bergamot, bitter, spicy, sweet, warm, non-toxic, into the liver, spleen, stomach three, with liver and qi, and gastrointestinal pain relief, for liver and stomach qi stagnation, stomach full, less food Vomiting, has obvious inhibitory effect on intestinal smooth muscle, has antispasmodic effect on intestinal fistula; expands coronary vessels and increases coronary flow; high concentration can weaken myocardial contractility, slow heart rate, lower blood pressure, protect heart muscle Ischemia; has a certain sputum effect. Yam, sweet, cool, into the lungs, spleen, kidney, contains amylase, polyphenol oxidase and other substances, is conducive to the digestion and absorption of the spleen and stomach, is a flat-bodied spleen and stomach for food and food. Whether it is spleen yang deficiency or stomach yin deficiency, it can be eaten. Clinically, it is often used together with gastrointestinal drink to treat spleen and stomach weakness, eating less body fatigue, diarrhea and other diseases. Invigorating the spleen, nourishing the lungs, solidifying the kidney, benefiting the essence; attending spleen deficiency and diarrhea, eating less edema, lung deficiency and cough, thirst, nocturnal emission, taking down, kidney deficiency and frequent urination. Chuanxiongzi, bitter taste, cold; small poison, liver, small intestine, bladder. Shugan qi and pain, deworming. For chest flank, abdominal pain, pain, abdominal pain. Decline, sexual, warm, return to the liver, spleen. Exercise qi and blood, relieve pain, stop bleeding. For abdominal pain, liver depression, hypochondriac pain, chest pain, puncture injury, traumatic bleeding; and vomiting and abdominal pain caused by cold pain or turbid internal resistance. Iris, sweet, mild, non-toxic; heart, liver, spleen, with phlegm and phlegm, soothe the nerves, Xuan spleen, detoxification; main fever, dizziness, epilepsy, air-closed deafness, dreams, forgetful, Chest tightness, bloating, loss of appetite, rheumatism, phlegm, phlegm and other symptoms. Asparagus, taste: sweet, bitter, cold; return to the lungs, kidney. For yin deficiency fever, dry lung cough, fatigue cough, Tianjin wound thirst, upset insomnia, internal heat and thirst, intestinal dry constipation, lung sputum, lung sputum, diphtheria and other symptoms; inhibition of a variety of bacteria, anti- Tumor activity, can nourish yin and spleen, moisten the lungs and clear the heart, remove dryness and reduce fire. Cuttlefish bone, containing calcium carbonate, can neutralize stomach acid, relieve symptoms of vomiting and heartburn, promote inflammation of the ulcer surface, prevent bleeding, relieve local pain. It can be used as an antacid. Experiment shows: its compound preparation Wubei San It has obvious adsorption of pepsin and neutralizes gastric acid, which can reduce the stimulation of gastric ulcer on gastric ulcer surface and reduce the digestion of protease on the ulcer surface, which is beneficial to the stomach. Pinellia, spicy, warm, poisonous. Return to the spleen, stomach, lungs. It has the functions of dampness and phlegm, lowering vomiting, eliminating phlegm and dissipating sputum; attending cough and phlegm, vomiting and nausea, chest fullness, headache, dizziness, night restlessness, sputum nucleus, carbuncle swollen poison embolism. Corydalis, temperature, taste, bitterness, liver, spleen, stomach, is a wonderful product of promoting blood circulation, relieving pain and relieving pain, especially known for its anti-pain effect. Indications for chest flank, abdominal pain, menstrual dysmenorrhea, postpartum stagnation, swelling and swelling. Birthplace, sweet, bitter, cold; heart, liver, lung. Cool serum heat, nourishing yin and tonifying kidney, Shengjin quenching thirst, often used to treat bone steaming heat, sore throat, bloody sputum. In combination with other traditional Chinese medicines of the invention, the curative effect is remarkable. Jujube, jujube is warm and sweet, contains protein, fat, sugar, calcium, phosphorus, iron, magnesium and rich vitamins. It also contains carotene, etc. It is very rich in nutrients. It has the functions of tonifying the spleen, nourishing the blood, calming the nerves, and regulating the blood. It has the functions of moistening the lungs and relieving pain, and relaxing the bowels and laxatives. It has the functions of moistening the lungs and strengthening the spleen, relieving cough, supplementing the five internal organs, and treating the deficiency. From the perspective of traditional Chinese medicine, the traditional Chinese medicine for chronic colitis is classified as "diarrhea" and "white peony". The clinical symptoms are chronic diarrhea, abdominal pain, mucus and bloody stools, chronic recurrent or persistent seizures. The course of the disease is longer, mostly due to long-term unhealthy diet, fatigue and internal injuries, resulting in weakness of the spleen and stomach. The combination of the above traditional Chinese medicine and the preparation method can effectively achieve the effect of regulating the intestinal tract and the internal organs by using a dialectical method, has no toxic and side effects, and has stable effects, and achieves twice the result with half the effort with western medicine. Clinical Experiment 1:
1 )、观察时间:在本发明技术方案未曾披露的情况下,选择 2011 年 4月到 2011年 9月的 6个月时间。 2 )、观察对象: 在广东省深圳市中医院消化科选择 10例慢性结 肠炎病例: 男 5例, 女 5例; 年龄: 41一 55岁 5例, 62— 75岁 5例; 职业: 普通上班族 5例, 退休人员 5例。 病症: 反复发作的腹痛、 腹 胀、 腹泻、 泻下粘液或脓血便, 发作期大便 3次 /日以上, 伴排便不 畅或里急后重;舌苔多黄腻或白腻;全部病便均经纤维肠镜检査确诊。 1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the six months from April 2011 to September 2011 are selected. 2), observation object: 10 cases of chronic colitis were selected in the Department of Gastroenterology, Shenzhen Hospital of Guangdong Province: 5 males and 5 females; age: 5 cases of 41-55 years old, 5 cases of 62-75 years old; occupation: ordinary There are 5 office workers and 5 retirees. Symptoms: recurrent abdominal pain, bloating, diarrhea, diarrhea mucus or pus and bloody stools, 3 times per day of bowel movements, with poor bowel movements or urgency; the tongue is yellowy or greasy; all diseases are treated with fiberoptic colonoscopy Check the diagnosis.
3 ) 、 使用方法: 将本发明制剂口服液在餐后半小时服用, 每日 3次, 每次 200ml, 2个月为 1疗程, 3个疗程作为疗效观察。 3), How to use: The oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses of treatment as therapeutic effects.
4 )、 观察效果: 4), observation effect:
在连续服用 3个疗程后, 临床症状、 体征消失, 纤维肠镜复査正 常,肠黏膜病变恢复正常的 4例,临床症状明显减轻,体征基本消失, 纤维肠镜复査好转, 肠黏膜病变明显改善的 4例, 治疗前后临床症状 和体征无改善, 纤维肠镜复査无好转的 2例, 总有效率 80%。  After taking 3 courses of treatment continuously, the clinical symptoms and signs disappeared, the fiber colonoscopy was normal, and 4 cases of intestinal mucosal lesions returned to normal. The clinical symptoms were alleviated, the signs disappeared, the fiber colonoscopy was improved, and the intestinal mucosal lesions were obvious. In the 4 cases improved, there were no improvement in clinical symptoms and signs before and after treatment, and 2 cases with no improvement in fiber colonoscopy, the total effective rate was 80%.
临床实验 2:  Clinical trial 2:
1 )、观察时间: 在本发明技术方案未曾披露的情况下, 选择 2011 年 2月到 2011年 7月的 6个月时间。  1) Observation time: In the case that the technical solution of the present invention has not been disclosed, the time from February 2011 to July 2011 is selected.
2 )、 观察对象: 在广东省深圳市福田区中医院消化科选择 20例 病例: 男 10例, 女 10例; 年龄: 33— 55岁 10例, 58— 75岁 10例; 职业: 曾担任领导岗位公务员 10例, 普通教师 10例。 病症: 反复发 作的腹痛、 腹胀、 腹泻、 泻下粘液或脓血便, 发作期大便 3次 /日以 上, 伴排便不畅或里急后重; 舌苔多黄腻或白腻; 全部病便均经纤维 肠镜检査确诊。 3 )、 使用方法: 将本发明制剂口服液在餐后半小时服用, 每日 3 次, 每次 200ml, 2个月为 1疗程, 3个疗程作为疗效观察。 2), Observed subjects: 20 cases were selected in the Department of Gastroenterology, Futian District Hospital, Shenzhen, Guangdong Province: 10 males and 10 females; Age: 10 cases of 33-55 years old, 10 cases of 58-75 years old; Occupation: There were 10 civil servants in leadership positions and 10 in general. Symptoms: recurrent abdominal pain, bloating, diarrhea, diarrhea mucus or pus and bloody stools, 3 times per day of bowel movements, with poor bowel movements or heavy urgency; thick yellow tongue or greasy tongue; all diseases are treated with fiber enteroscopy Check the diagnosis. 3), How to use: The oral liquid of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for 1 course of treatment, and 3 courses of treatment as therapeutic effects.
4 )、 观察效果:  4), observation effect:
在连续服用 3个疗程后, 临床症状、 体征消失, 纤维肠镜复査正 常, 肠黏膜病变恢复正常的 10例, 临床症状明显减轻, 体征基本消 失, 纤维肠镜复査好转, 肠黏膜病变明显改善的 5例, 治疗前后临床 症状和体征无改善, 纤维肠镜复査无好转的 5例, 总有效率 75%。  After taking 3 courses of treatment, the clinical symptoms and signs disappeared, the fiber colonoscopy was normal, and 10 cases of intestinal mucosal lesions returned to normal. The clinical symptoms were obviously relieved, the signs disappeared, the fiber colonoscopy was improved, and the intestinal mucosal lesions were obvious. In 5 cases improved, there were no improvement in clinical symptoms and signs before and after treatment. There were 5 cases of no improvement in fiber colonoscopy, and the total effective rate was 75%.
临床实验 3:  Clinical Trial 3:
1 )、观察时间: 在本发明技术方案未曾披露的情况下, 选择 2013 年 6月到 2013年 11月的 6个月时间。  1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the six months from June 2013 to November 2013 are selected.
2 )、 观察对象: 在广东省深圳市松岗人民医院消化科选择 30例 病例: 男 14例, 女 16例; 年龄: 35— 55岁 16例, 60— 75岁 14例; 职业: 普通民营企业主 14例, 普通退休教师 16例。 病症: 反复发作 的腹痛、腹胀、腹泻、泻下粘液或脓血便,发作期大便 3次 /日以上, 伴排便不畅或里急后重; 舌苔多黄腻或白腻; 全部病便均经纤维肠镜 检査确诊。  2), Observed subjects: 30 cases were selected in the Department of Gastroenterology, Songgang People's Hospital, Shenzhen, Guangdong Province: 14 males and 16 females; Age: 16 cases of 35-55 years old, 14 cases of 60-75 years old; Occupation: Ordinary private enterprise There are 14 main cases and 16 ordinary retired teachers. Symptoms: recurrent abdominal pain, bloating, diarrhea, diarrhea mucus or pus and bloody stools, 3 times/day of bowel movements during episodes, with poor bowel movements or heavy urgency; thick yellow tongue or greasy tongue; all diseases are treated with fiber enteroscopy Check the diagnosis.
3 )、 使用方法: 将本发明制剂口服液在餐后半小时服用, 每日 3 次, 每次 200ml, 2个月为 1疗程, 3个疗程作为疗效观察。  3), How to use: The oral solution of the preparation of the present invention is taken half an hour after a meal, 3 times a day, 200 ml each time, 2 months for a course of treatment, and 3 courses for observation of curative effect.
4 )、 观察效果:  4), observation effect:
在连续服用 3个疗程后, 临床症状、 体征消失, 纤维肠镜复査正 常, 肠黏膜病变恢复正常的 20例, 临床症状明显减轻, 体征基本消 失, 纤维肠镜复査好转, 肠黏膜病变明显改善的 5例, 治疗前后临床 症状和体征无改善, 纤维肠镜复査无好转的 5例, 总有效率 84%t 结合以上临床数据及本发明的理论依据,可见本发明有益效果在 于, 本发明制成的制剂, 对于治疗慢性结肠炎具有良好效果, 而且无 毒, 无副作用, 效果稳定, 制取工艺简便易行。 具体实 式 After taking 3 courses of treatment continuously, the clinical symptoms and signs disappeared, the fiber colonoscopy was normal, and 20 cases of intestinal mucosal lesions returned to normal. The clinical symptoms were alleviated, the signs disappeared, the fiber colonoscopy was improved, and the intestinal mucosal lesions were obvious. 5 cases improved, clinical before and after treatment No improvement in symptoms and signs, 5 cases of no improvement in fiber colonoscopy, total effective rate 84% t combined with the above clinical data and the theoretical basis of the present invention, it can be seen that the beneficial effects of the present invention are that the preparation prepared by the present invention is for treatment Chronic colitis has good effects, and it is non-toxic, has no side effects, and has a stable effect. The preparation process is simple and easy. Concrete real
下面结合实施例对本发明详细加以说明:  The present invention will be described in detail below with reference to the embodiments:
实施例 1:  Example 1:
本发明制剂是由厚朴、茯苓、吴茱萸、黄芪、甘草、三七、大黄、 白芍、 佛手、 山药、 川楝子、 降香、 节菖蒲、 天冬、 贼骨、 半夏、 延 胡索、 生地和红枣制备成的组合物制剂, 其中各组分的质量配比为: 厚朴 12g 茯苓 10g 吴茱萸 10g 黄芪 12g 甘草 12g 三七 15g 大黄 10g 白芍 12g 佛手 8g 山药 15g 川楝子 15g 降香 13g 节菖蒲 12g 天冬 8g 贼骨 10g 半夏 12g 延胡索 13g 生地 10g 红枣 16g。  The preparation of the invention is from Magnolia officinalis, Poria, Evodia, Radix Astragali, Radix Glycyrrhizae, Radix Notoginseng, Rhubarb, Radix Paeoniae Alba, Bergamot, Yam, Chuanxiongzi, Jiangxiang, Jatropha, Asparagus, Skull, Pinellia, Yanhusuo, Shengdi And the preparation of the composition prepared by the red jujube, wherein the mass ratio of each component is: Magnolia 12g 茯苓10g Wujing 10g Astragalus 12g Licorice 12g Sanqi 15g Rhubarb 10g White Pelican 12g Bergamot 8g Yam 15g Chuanxiong 15g Fragrance 13g Festival Iris 12g asparagus 8g thief bone 10g Pinellia 12g Yanhusuo 13g soil 10g jujube 16g.
上述治疗慢性结肠炎中药制剂的制备方法, 包括如下歩骤: 1 )、将茯苓放入小锅进行小炒至表面微焦, 然后经粉碎机粉碎并 过 80目筛, 备用; 2 )、 将厚朴、 吴茱萸、 黄芪、 甘草、 大黄、 白芍、 佛手、 红枣、 半夏、 延胡索按比例配好, 经过粉碎机粉碎成粉末并过 90 目筛, 自 然晾干, 备用; The preparation method of the traditional Chinese medicine preparation for treating chronic colitis includes the following steps: 1) placing the cockroach into a small pot for small frying until the surface is slightly coke, and then pulverizing through a pulverizer and passing through a 80 mesh sieve for use; 2), the magnolia, Wujing, Astragalus, licorice, rhubarb, white peony, bergamot, red dates, pinellia, yanhusuo are proportioned well, pulverized into powder after crushing machine and passed through a 90 mesh sieve, naturally dried, ready for use;
3 )、 将歩骤 1 ) 和 2 ) 中的各组分粉末混合在一起, 加入纯净水 煎煮两次, 第一次加入 8倍纯净水小火煎煮 1小时, 第二次加入 4倍 纯净水小火煎煮半小时, 然后合并煎液并过滤, 备用;  3), mix the powders of each component in steps 1) and 2), add boiling water twice, add 8 times pure water for 1 hour, simmer for 1 hour, and add 4 times for the second time. Decoction in pure water for half an hour, then combine the decoction and filter, set aside;
4 )、将剩下的三七、 山药、川楝子、 降香、节菖蒲、天冬、贼骨、 生地按比例配好, 经过粉碎机粉碎成粉末并过 80 目筛, 自然晾干, 备用;  4), the remaining Sanqi, Yam, Chuanxiongzi, Jiangxiang, Iris, asparagus, ribs, and raw land are proportioned well, crushed into powder by a pulverizer and passed through a 80 mesh sieve, and dried naturally. Standby
5 )、 将歩骤 4) 中各组分粉末混合在一起, 加入 4〜6倍70%〜80% 的乙醇, 加热回流 3〜5个小时, 提取过滤获得滤液; 然后在剩下的药 渣中再次加入 2〜4倍65%〜75%的乙醇, 加热回流 2〜3个小时, 提取过 滤获得滤液;将两次获得的滤液合并在一起,减压浓缩除去乙醇溶剂, 干燥, 获得干膏;  5), mixing the powders of each component in step 4), adding 4 to 6 times 70%~80% ethanol, heating and refluxing for 3 to 5 hours, extracting and filtering to obtain a filtrate; and then remaining the dregs Adding 2 to 4 times of 65% to 75% ethanol again, heating and refluxing for 2 to 3 hours, extracting and filtering to obtain a filtrate; combining the filtrates obtained twice, removing the ethanol solvent under reduced pressure, and drying to obtain a dry paste. ;
6 )、 将上述歩骤 5 ) 中获得的干膏进行超微粉碎成粉末并过 200 目筛, 然后将粉末加入歩骤 3 ) 中的合并煎液, 混合摇匀即可制得。  6), the dry paste obtained in the above step 5) is ultra-pulverized into a powder and passed through a 200 mesh sieve, and then the powder is added to the combined decoction in the step 3), and mixed and shaken to obtain.
制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚 各饮用一次并长期饮用, 效果更好。  The preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better.
实施例 2:  Example 2:
本发明还可优选的原料质量为 (克):  The preferred raw material quality of the present invention is (g):
厚朴 12g 茯苓 10g 吴茱萸 10g 黄芪 12g 甘草 12g 三七 15g 大黄 10g 白芍 12g 佛手 8g 山药 15g 川楝子 10g 降香 13g 节菖蒲 12g 天冬 8g 贼骨 10g 半夏 12g 延胡索 13g 生地 10g 红枣 16g0 Magnolia 12g 茯苓10g Wu Hao 10g Huang Qi 12g Licorice 12g Sanqi 15g Rhubarb 10g White peony 12g Bergamot 8g Yam 15g Chuanxiong 10g Fragrance 13g Iris pupa 12g Asparagus 8g Rib bone 10g Pinellia 12g Corydalis 13g Raw land 10g Red date 16g 0
制备方法如实施例 1。 The preparation method is as in Example 1.
实施例 3: Example 3:
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
厚朴 15g 茯苓 12g 吴茱萸 9g 黄芪 15g 甘草 10g 三七 12g 大黄 12g 白芍 10g 佛手 8g 山药 12g 川楝子 14g 降香 12g 节菖蒲 8g 天冬 8g 贼骨 12g 半夏 10g 延胡索 8g 生地 10g 红枣 15gc Magnolia 15g 茯苓12g Wujing 9g Astragalus 15g Licorice 10g Sanqi 12g Rhubarb 12g White peony 10g Bergamot 8g Yam 12g Chuanxiong 14g Fragrance 12g Jatropha 8g Asparagus 8g Rib bone 12g Pinellia 10g Corydalis 8g Fertile land 10g Jujube 15g c
制备方法如实施例 1。  The preparation method is as in Example 1.
实施例 4: Example 4:
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
厚朴 18g 茯苓 15g 吴茱萸 12g 黄芪 16g 甘草 12g 三七 15g 大黄 13g 白芍 15g 佛手 12g 山药 16g 川楝子 14g 降香 16g 节菖蒲 10g 天冬 12 贼骨 15g 半夏 16g 延胡索 生地 12g 红枣 18g。 Magnolia 18g 茯苓15g Wu Wei 12g Huang Qi 16g Licorice 12g Sanqi 15g Rhubarb 13g White Pelican 15g Bergamot 12g Yam 16g Chuanxiong 14g Fragrance 16g Jatropha 10g Asparagus 12 Rib bone 15g Pinellia 16g Yanhusuoshengdi 12g Jujube 18g.
制备方法如实施例 1。 The preparation method is as in Example 1.
实施例 5: Example 5
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
厚朴 16g 茯苓 18g 吴茱萸 15g 黄芪 14g 甘草 15g 三七 18g 大黄 15g 白芍 18g 佛手 14g 山药 18g 川楝子 16g 降香 14g 节菖蒲 12g 天冬 13 贼骨 13g 半夏 18g 延胡索 生地 15g 红枣 18g。 Magnolia 16g 茯苓 18g Wujing 15g Huangqi 14g Licorice 15g Sanqi 18g Rhubarb 15g White peony 18g Bergamot 14g Yam 18g Chuanxiong 16g Fragrance 14g Iris chinensis 12g Asparagus 13 Rib bone 13g Pinellia 18g Yanhusuo 15g Jujube 18g.
制备方法如实施例 1。 The preparation method is as in Example 1.
实施例 6: Example 6:
本发明还可优选的原料质量为 (克): The preferred raw material quality of the present invention is (g):
厚朴 15g 茯苓 18g 吴茱萸 15g 黄芪 16g 甘草 15g 三七 20g 大黄 12g 白芍 20g 佛手 16g 山药 16g 川楝子 18g 降香 15g 节菖蒲 15g 天冬 15g 贼骨 12g 半夏 16g 延胡索 16g 生地 13g 红枣 20g。 Magnolia 15g 茯苓18g Wujing 15g Astragalus 16g Licorice 15g Sanqi 20g Rhubarb 12g White peony 20g Bergamot 16g Yam 16g Chuanxiong 18g Fragrance 15g Jatropha 15g Asparagus 15g Rib bone 12g Pinellia 16g Yanhusuo 16g Biographa 13g Red dates 20g.
制备方法如实施例 1。  The preparation method is as in Example 1.
上述实施例仅是本发明众多实施方式的几种,如将各配方按技术方案 中的比例加大或减小药量,制得的这种治疗慢性结肠炎制剂疗效并不 受影响, 也将落在本发明的权利保护范围之内。 The above embodiments are only a few of the various embodiments of the present invention. For example, if the formula is increased or decreased according to the ratio in the technical solution, the therapeutic effect of the preparation of the chronic colitis preparation is not affected, and It is within the scope of the protection of the present invention.

Claims

权利要求 Rights request
1、 一种治疗慢性结肠炎的中药制剂, 其特征在于, 本发明制剂 是由厚朴、 茯苓、 吴茱萸、 黄芪、 甘草、 三七、 大黄、 白芍、 佛手、 山药、 川楝子、 沉香、 节菖蒲、 天冬、 贼骨、 半夏、 延胡索、 生地和 红枣制备成的组合物制剂, 其中各组分的质量配比为: 1. A traditional Chinese medicine preparation for the treatment of chronic colitis, characterized in that the preparation of the present invention is composed of Magnolia officinalis, Poria cocos, Evodia, Astragalus, licorice, Panax notoginseng, rhubarb, white peony root, bergamot, yam, toodandan, agarwood, A composition preparation prepared from Acorus calamus, Asparagus Asparagus, Cortex Pinellia, Corydalis Corydalis, Rehmannia Rehmanniae and Jujube, in which the mass ratio of each component is:
厚朴 12-20g
Figure imgf000017_0001
10-22g
Magnolia officinalis 12-20g
Figure imgf000017_0001
10-22g
8- 18g 8-18g
黄芪 10_18g 甘草 8-15g
Figure imgf000017_0002
Astragalus 10_18g Licorice 8-15g
Figure imgf000017_0002
10-20g 10-20g
大黄 8-16g 白芍 12-20g 佛手 8-16g 山药 10-18g 川楝子 10- 18g Rhubarb 8-16g, white peony root 12-20g, bergamot 8-16g, yam 10-18g, toodan 10-18g
10- 18g 10-18g
节菖蒲 8-15g 天冬 6-15g 贼骨 8-15g 半夏 10-18g 延胡索 8-16g 生地 8-15g 红枣 10-20g。 Acorus calamus 8-15g Asparagus 6-15g Thieves bone 8-15g Pinellia ternata 10-18g Corydalis 8-16g Rehmannia 8-15g Red dates 10-20g.
2、 根据权利要求 1所述的治疗慢性结肠炎的中药制剂, 其特征 还在于, 其中各组分的质量配比为: 2. The traditional Chinese medicine preparation for treating chronic colitis according to claim 1, further characterized in that the mass ratio of each component is:
厚朴 12_18g 苓 10-18g 吴茱萸 Magnolia officinalis 12_18g Ling 10-18g Evodia
8-12g 8-12g
黄芪 12-18g 甘草 8-12g 三七 10-15g 大黄 8-12g 白芍 12-16g 佛手 8-12g 山药 10-15g 楝子 10-14g 10-15g Astragalus 12-18g, licorice 8-12g, Panax notoginseng 10-15g, rhubarb 8-12g, white peony root 12-16g, bergamot 8-12g, yam 10-15g, neem 10-14g 10-15g
节菖蒲 8-12g 天冬 6-10g 贼骨 8-12g 半夏 10-15g 延胡索 8-12g 生地 8-12g 红枣 12-18g。 Cortex calamus 8-12g Asparagus Asparagus 6-10g Thieves bone 8-12g Pinellia ternata 10-15g Corydalis 8-12g Rehmannia 8-12g Red dates 12-18g.
3、 根据权利要求 1或 2所述的治疗慢性结肠炎的中药制剂, 其 特征还在于, 其中各组分的质量配比为 3. The traditional Chinese medicine preparation for treating chronic colitis according to claim 1 or 2, further characterized in that the mass ratio of each component is
厚朴 15g 茯苓 12g 吴茱萸 9g 黄芪 15g 甘草 10g 三七 12g 大黄 12g 白芍 10g 佛手 8g Magnolia officinalis 15g Poria 12g Evodia 9g Astragalus 15g Licorice 10g Panax notoginseng 12g Rhubarb 12g White peony root 10g Bergamot 8g
山药 12g 川楝子 14g 降香 12g 节菖蒲 8g 天冬 8g 贼骨 12g 半夏 10g 延胡索 8g 生地 10g 红枣 15gc 12g Chinese yam, 14g Melanium japonica, 12g Acorus calamus 8g Asparagus asparagus 8g, 12g Pinellia ternata 10g, Corydalis 8g, Rehmannia glutinosa 10g, red dates 15g c
4、 一种治疗慢性结肠炎的中药制剂的制备方法, 其特征在于, 其包括如下歩骤: 4. A method for preparing a traditional Chinese medicine preparation for treating chronic colitis, which is characterized in that it includes the following steps:
1 )、将茯苓放入小锅进行小炒至表面微焦, 然后经粉碎机粉碎并 过 80目筛, 备用; 1). Put Poria cocos into a small pot and fry until the surface is slightly charred, then grind it with a grinder and pass it through an 80-mesh sieve, and set aside;
2 )、 将厚朴、 吴茱萸、 黄芪、 甘草、 大黄、 白芍、 佛手、 红枣、 半夏、 延胡索按比例配好, 经过粉碎机粉碎成粉末并过 90 目筛, 自 然晾干, 备用; 2). Mix magnolia bark, Evodia, astragalus, licorice, rhubarb, white peony root, bergamot, red dates, pinellia, and Corydalis in proportion, crush it into powder through a grinder and pass through a 90-mesh sieve, dry naturally and set aside;
3 )、 将歩骤 1 ) 和 2 ) 中的各组分粉末混合在一起, 加入纯净水 煎煮两次,第一次加入 10倍纯净水小火煎煮 1小时,提取滤液备用, 第二次加入 6倍纯净水小火煎煮半小时,然后合并煎液并过滤,备用; 3). Mix the powders of each component in steps 1) and 2) together, add purified water and cook twice. For the first time, add 10 times purified water and cook over low heat for 1 hour. Extract the filtrate and set aside. For the second time, add 6 times purified water and simmer over low heat for half an hour, then combine the decoctions and filter, set aside;
4 )、将剩下的三七、 山药、川楝子、 降香、节菖蒲、天冬、贼骨、 生地按比例配好, 经过粉碎机粉碎成粉末并过 80 目筛, 自然晾干, 备用; 4). Mix the remaining Panax notoginseng, Chinese yam, toodandan, alfalfa, calamus, asparagus, bone, and raw rehmannia in proportion, grind into powder through a grinder and pass through an 80-mesh sieve, and dry naturally. spare; spare
5 )、 将歩骤 4 ) 中各组分粉末混合在一起, 加入 4〜6倍70%〜80% 的乙醇, 加热回流 3〜5个小时, 提取过滤获得滤液; 然后在剩下的药 渣中再次加入 2〜4倍65%〜75%的乙醇, 加热回流 2〜3个小时, 提取过 滤获得滤液;将两次获得的滤液合并在一起,减压浓缩除去乙醇溶剂, 干燥, 获得干膏; 5). Mix the powders of each component in step 4) together, add 4 to 6 times of 70% to 80% ethanol, heat and reflux for 3 to 5 hours, extract and filter to obtain the filtrate; then add the remaining medicinal residue. Add 2 to 4 times of 65% to 75% ethanol again, heat and reflux for 2 to 3 hours, extract and filter to obtain the filtrate; combine the two filtrate obtained together, concentrate under reduced pressure to remove the ethanol solvent, and dry to obtain a dry paste. ;
6 )、 将上述歩骤 5 ) 中获得的干膏进行超微粉碎成粉末并过 200 目筛, 然后将粉末加入歩骤 3 ) 中的合并煎液, 混合摇匀即可制得。 制取的上述中药组合物溶液制剂可以用于口服,如果能够早中晚各适 量饮用一次并长期饮用, 效果更好。 6). Ultrafinely pulverize the dry paste obtained in the above step 5) into powder and pass it through a 200 mesh sieve. Then add the powder to the combined decoction in step 3), mix and shake well to prepare. The prepared above-mentioned Chinese medicine composition solution preparation can be taken orally. If it can be drunk once in the morning, noon and evening in an appropriate amount and for a long time, the effect will be better.
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