CN104758902A

CN104758902A - Traditional Chinese medicine for treating chronic gastritis caused by deficiency cold in spleen and stomach and preparation method of traditional Chinese medicine

Info

Publication number: CN104758902A
Application number: CN201510167763.XA
Authority: CN
Inventors: 刘宁; 王桦; 郭延举
Original assignee: Shandong Three Lives New Material Science And Technology Ltd
Current assignee: Shandong Three Lives New Material Science And Technology Ltd
Priority date: 2015-04-10
Filing date: 2015-04-10
Publication date: 2015-07-08

Abstract

The invention discloses a traditional Chinese medicine for treating chronic gastritis caused by deficiency cold in spleen and stomach and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine comprises the following raw materials: orange peel, agilawood, silverweed cinquefoil root, stichopus japonicas, buckeye, hispid arthraxon, viburnum fordiae, baked ginger, pericarpium arecae, thlaspi arvense, fingered citron, sambucus chinensis, persimmon calyx, white egret flower, starfish, angelica sinensis, rhizoma cyperi, alkaline marin, cynanchum wilfordii, procumbent speedwell, pericarpium citri reticulatae, herba cistanche, fructus psoraleae, castanea seguinii, trifoliate orange, fructus amomi, saccatespur larkspur, sandalwood, prostrate hemlock, fructus piperis longi, zanthoxylum avicennae, poria cocos, lucid ganoderma, radix pseudostellariae, rhizoma atractylodis macrocephalae, primula obconica and cyananthus argernteus marg. The traditional Chinese medicine for treating chronic gastritis caused by deficiency cold in spleen and stomach has the functions of warming middle, invigorating spleen and regulating stomach to relieve pain, is mainly used for treating chronic gastritis caused by deficiency cold in spleen and stomach, is capable of treating treatment based on syndrome differentiation by using the theory of traditional Chinese medicine, is relatively high in pertinence, can be used for treating the same disease with different methods according to the different clinical stages of the diseases and treating different diseases with the same method according to the similar diseases, has the effects of removing helicobacter infections, protecting gastric mucosa, eliminating cold to stop pain and improving overall immunity of the organism, and has the advantages of being quick in effect, high in effective rate, obvious in curative effect, short in treatment course, free of toxic and side effects and low cost.

Description

A kind ofly treat medicine of spleen-stomach deficiency-cold chronic gastritis and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind ofly treat medicine of spleen-stomach deficiency-cold chronic gastritis and preparation method thereof.

Background technology

The pathological change of chronic gastritis, is confined to mucous layer substantially, therefore strictly says and should be referred to as " chronic gastric mucositis " or " gastric mucosa is sick ".According to the record of Schindler, " chronic gastritis " is that first Stahl proposed in 1728, constantly reports to some extent thereafter.But all the time difference is existed to this diagnosis.Especially after Cruveilhier in 1830 finds gastric ulcer, for the patient having epigastrium pain, be often diagnosed as Peptic Ulcers or stomach neurosis and do not diagnose gastritis.Until 1932, Schindler directly can observe gastric mucosa change preferably with bending gastroscope, after getting mucosa group inspection alive again, just improves a step to the diagnosis of gastritis with operating gastroscope.He is divided into constitutional and Secondary cases two class chronic gastritis, and primary gastritis is divided into again shallow, atrophic and hypertrophica 3 kinds.

The pathogenesis of chronic gastritis: 1. more than stove atrophic gastritis (Type B gastritis): the topmost cause of disease is helicobacter pylori.Bad diet and the prolonged and repeated susceptible human body that acts on of environmental factors, physical property, chemical and other biological harmful factor also can cause primary disease.As coarse with high salt in irritable food, diet and shortage fresh vegetables fruit, medicine, excessive drinking, NSAID (non-steroidal anti-inflammatory drug), potassium chloride, iodine, chalybeate and Duodenal reflux etc.2. autoimmune gastritis (A type gastritis): there is autoantibody in blood samples of patients as parietal cell antibody, companion pernicious anemia person also can find intrinsic factor antibody.Autoantibodies attack parietal cell, makes parietal cell mass reduce, and causes gastric acid secretion to reduce or loses; The intrinsic factor of being secreted by parietal cell is lost.Cause vitamin B12 malabsorption and cause pernicious anemia.

Chronic gastritis symptom and sign: 1. symptom: the modal symptom of chronic gastritis is Upper abdominal pain and glutted.Contrary with Peptic Ulcers pleasant on an empty stomach, uncomfortable after meal, possibility is because of diastolic dysfunction of holding, though the few feel satiety of feed.Patient often tells " stomach is weak " or " stomach is soft ".Often because cold drinks and snachs, hard food, pungent or other irritable foods cause symptom or make exacerbation of symptoms.These symptom antacid and spasmolytic are not easily alleviated.Most patient tells inappetence.In addition, hemorrhage is also one of symptom of chronic gastritis, especially merges erosion.Can be repeatedly small amount bleeding, also can be massive hemorrhage.Emergency gastroscopy is pointed out, and in the cause of disease of upper gastrointestinal hemorrhage, acute or chronic gastritis accounts for 20% ~ 40%.Hemorrhage is common with melena, generally continues automatically to stop blooding afterwards for 3 ~ 4 days, can send out after several months or several years again.The pathological change of gastritis and symptom are also inconsistent.2. sign: most patient has Huang, the thick greasy tongue fur of white.Simple ulcer patient is without tongue fur or have thin and whitish fur, is the difference of two kinds of gastropathy.Epigastrium can have tenderness.A few patients is become thin, anemia.In addition without special signs.

Chinese medicine is thought, chronic gastritis belongs to the category such as motherland's medical science " stomachache ", " feeling of fullness ", " vomiting ", " singultus ".Stomachache is due to gastric qi retardance, stomach network stasis blocking, and stomach is become homeless foster, a kind of taste enteropathy card being primary symptom with upper abdomen gastral cavilty portion generation pain that stagnation of QI and blood may bring about pain causes.Stomachache, also known as gastric abscess.

The etiology and pathogenesis of chronic gastritis: the cause of disease of stomachache is mainly diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, and feelings will is unsuccessful, weakness of the spleen and stomach etc.1. cold-evil visitor stomach, cold belongs to YIN pathogen, and its property stagnates spasm.Gastral cavilty top communicates with the external world with mouth, very cold, and cold-evil inhales people by mouth, or gastral cavity abdomen is suffered from cold, cold-evil's direct attack, and interior visitor in stomach, or takes medicine bitter cold too, or cold food damaging the spleen and stomach, and cause QI stagnated by cold, gastric qi is become estranged, and gastric qi blocks, stagnation of QI and blood may bring about pain.Said as " Plain Questions lifts a pain opinion section ": " between the intestines and stomach, under film is former, blood must not fall apart cold visitor, and little network is anxious to be drawn, therefore pain." 2. diet injure one's stomach, stomach receiving food and drink digesting food, its gas with reduce to suitable, therefore stomachache generation and eating and drinking without temperance relation the closest.If eating and drinking without temperance, eating and drinking too much at one meal, impairing the spleen and stomach, retention of food and drink, causes gastric qi to be become estranged, mechanism of qi retardance in stomach, stagnation of QI and blood may bring about pain; Or the five tastes cross pole, pungent immoderate, or addiction to greasy and sweet foods savoury, or drink as slurry, then the impairment of the spleen hinders stomach, accumulates humidogene heat, retardance mechanism of qi, so that gastric qi retardance, and stagnation of QI and blood may bring about pain, all can cause stomachache.Therefore " Plain Questions, a numbness opinion section " is said: " eating twice as usual, the intestines and stomach is wound." " medical science main story, gastric abscess " say: " and just cause a disease by, how because of self-indulgent food, it is sad to like, and throw off restraint the hot wine of drink and decoct torch, cold and cool raw food of eating again, damage dusk towards wound, it is dark that day amasss the moon ... therefore gastralgia." 3. hyperactive liver-QI attacking the stomach, the lifting being received transporting, middle burnt mechanism of qi of taste, depend on the catharsis of liver, " Plain Questions, a precious life holotype opinion section " said " earth being dredged by wood " namely means this.So pathology just there will be wood prosperous gram of soil, or change of deficient earth being subjugated by wood.Be worried angry, feelings will is unsuccessful, the liver failing to maintain the normal flow of QI, stagnation of QI due to depression of the liver, and perverse and unreasonable manner violates stomach, so that gastric qi is become estranged, and gastric qi blocks, and can send out as stomachache.So " miscellaneous diseases source and course rhinoceros is lit up, gastropathy source and course " meaning: " stomachache, evil dry gastral cavilty disease also.Only irritability is multiplied for more so, sudden and violent with wood, and just gram also." stagnation of liver-QI with the passing of time, again can fire-transformation heat-dissipating, heat invading the stomach, causes syndrome of liver-stomach heat and pain.If the liver failing to maintain the normal flow of QI, functional activity of QI being not smooth, the blood stasis of blood is stagnant, can form blood stasis again, doublely sees that blood stasis is had a stomachache.Gallbladder and liver phase the exterior and the interior, all belong to wood.Gallbladder leading to falls, and the transporting and the stomach sum that contribute to spleen are fallen." Ling Shu Miraculous Pivot or Divine Axis, four seasonal epidemic pathogens " are said: " evil in gallbladder, inverse at stomach." if gallbladder disease loses in catharsis, gallbladder internal organs is logical to fall not normal, and courage is not fallen, the criminal's of driving in the wrong direction stomach, causes gastric qi and becomes estranged, and the retardance of liver and gall gastric qi machine, also can have a stomachache.4. weakness of the spleen and stomach, spleen and stomach phase the exterior and the interior, with placed in the middle burnt, play altogether and received the merit of transporting and transforming nutrients from foodstuff.Splenic qi tending to ascend, stomach-QI being apt to descend, being received of stomach is become thoroughly decomposed, and rely the transporting the lucid yang sending up of spleen, so gastropathy is often involved in spleen, the splenopathy is often involved in stomach.If ferritic is not enough, or overstrain, or injury due to diet, or excessively take cold and cool medicine, or prolonged illness taste are impaired, all can cause weakness of the spleen and stomach, deficiency-cold in middle-JIAO, cause stomach to lose replenishing vital QI with drugs of warm nature, have a stomachache.If consumption of YIN caused by febrile disease, or gastric heat fire stagnation, stomach-Yin of burning, or take fragrant dry crystalline substance of regulating the flow of vital energy for a long time, consume the moon that injures one's stomach, stomach mistake is moistened foster, also can cause stomachache.The kidney being the origin of congenital constitution, root of YIN and YANG, the sun of taste, entirely relies the warm of kidney yang; The moon of taste, the full nourishing relying kidney yin.If insufficiency of kidney-YANG, the not warm soil of fire, can cause deficiency of spleen-YANG, form deficiency of spleen-YANG and kidneyYANG, stomach loses the stomachache of replenishing vital QI with drugs of warm nature; If deficiency of kidney-YIN, kidney water can not go up Ji stomach-Yin, can cause deficiency of stomach-YIN, forms stomach deficiency of the kidney yin.Stomach loses and moistens foster stomachache.

In addition, if the stagnation of QI with the passing of time, the blood stasis of blood is stagnant, or pain people network of a specified duration, and stomach network is obstructed, or after gastrorrhagia, blood circulating out of vessels does not eliminate, so that stops in blood stasis, and the retardance of stomach network is obstructed, and blood stasis all can be caused to have a stomachache." Linzheng Zhinan Yi gastric abscess " has the discussion about this pathogenesis already: " stomachache is sent out for a long time and repeatly, and solidifying expectorant must be had to gather the stasis of blood.If " spleen YANG deficiency, lose in strong fortune, endogenous dampness, the poly-expectorant that wets into becomes drink, accumulation gastral cavilty, can cause again phlegm retention stomachache.

Analyze the cause of disease of chronic gastritis, distinguish that its clinical syndrome is divided into: 1, cold-evil visitor gastric pattern: stomachache is done cruelly, and very then contracture is had a pain, pain alleviated while getting warmth, pain increase in intensity under coldness, tastelessness and no thirst, or desire for hot drinks, white and thin fur, stringy and tense pulse.2, diet-stasis: after eating and drinking too much at one meal, gastralgia, distension does not disappear, pain with tenderness, obtains food more very, belching and acid regurgitation, or vomiting indigestion food, its taste is rancid, tells rear alleviation of pain, anorexia or anorexia, defecate not well, must vow gas and slightly easypro after an action of the bowels, thick fur is greasy, and rolling pulse is strong.3, hyperactive liver-qi attacking the stomach: gastral cavilty distension, attacks support and has a pain, and gastralgia connects the side of body, belch uncomfortable in chest, and happiness is sighed breath, and stool is smooth, obtains belch, vows that gas then relaxes, meet worried disgruntled then pain do or pain very, white and thin fur, stringy pulse.4, liver stomach wind-cold type: burning pain in the epigastrium, pain gesture is urgent, and like cold aversion to heat, obtain cool, relax, susceptible to lose temper due to restlessness, pantothenic acid is noisy, dry mouth with bitter taste, the few tongue of red tongue, wiry and frequent pulse.5, blood stasis stationary form: gastralgia, aching as needle stabbing lancinates, localized pain, the pain of pressing very, aggravation after food, becoming severe at night, or see haematemesis, melena, purplish tongue or have ecchymosis, hesitant pulse.6, spleen and stomach damp-heat type: the scorching hot pain of gastral cavilty, noisy pantothenic acid, dry mouth with bitter taste, thirst but no desire to drink, sweet taste in the mouth glues turbid, and food sweet food then emits sour water, and indigestion and loss of appetite nauseating, heavy sensation of the body limb is tired, urine yellow skin, and stool is smooth, yellowish fur, the sliding number of pulse condition.7, stomach-yin deficiency: the indistinct causalgia of gastral cavilty, the loss of appetite like famine, dryness of the mouth and throat, thirsty think of drink, becomes thin weak, constipation with dry stool, red tongue with a little fluid or light stripping no fur, thready and rapid pulse.8, spleen-stomach deficiency-cold: stomachache is indistinctly, endlessly continuous, cold type of pain is uncomfortable, and like warm cream and press, pain of empty stomach is very, must eat, delay, tired or eat cold or panic attacks or increase the weight of, general vomiting watery fluid, lack of appetite, spiritlessness and weakness after suffering from cold, hands and feet being not warm, large loose stool is thin, pale tongue with white fur, deficient and weak pulse.

Current western medical treatment chronic gastritis mainly comprises the following aspects: 1. the factor avoiding causing acute gastritis, avoids taking to stomach food excitatory and medicine as NSAID etc. as given up tobacco and wine.2. Diet Therapy: principle is similar to Peptic Ulcers, repeatedly eats less, and soft diet is main, avoids raw food and irritable food, the more important thing is the dietary habit according to patient and many years of experience, sums up a set of recipe being applicable to oneself.3. Drug therapy: Hp Gastritis need carry out the treatment of eradicating Hp, can give dilute hydrochloric acid and pepsin in right amount.

But chronic gastritis there is no specific short, prolonged application high amount of drug is treated, and after some therapeutic scheme drug withdrawal, Hp breeds very soon once again, easily produces drug resistance, and treatment is long for the course for the treatment of, and easily recurs, and relapse rate is more high.

Summary of the invention

Technical problem to be solved by this invention is, there is provided a kind of and treat medicine of spleen-stomach deficiency-cold chronic gastritis and preparation method thereof, the present invention has warming middle-JIAO and strengthening the spleen, with effect of stomach and alleviating pain, cure mainly spleen-stomach deficiency-cold chronic gastritis, utilize Traditional Chinese medical theory, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, specific aim is stronger, the clinical stage different according to disease will carry out " treating the same disease with different methods ", carry out " treating different diseases with the same therapeutic principle " according to similar disease, can eliminating pylorus, protection gastric mucosa, dispersing cold for relieving pain, improve animal economy immunity, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine treating spleen-stomach deficiency-cold chronic gastritis, wherein, following raw medicinal material is comprised: Exocarpium Citri Rubrum, Lignum Aquilariae Resinatum, Radix potentillae anserinae, Radix Morinae Bulleyanae, Semen Aesculi, Herba Arthraxonis Hispidi, Radix Viburni fordiae, Rhizoma Zingiberis Preparatum, Pericarpium Arecae, Herba Thlaspis, Fructus Citri Sarcodactylis, Rhizoma seu Herba Elatostematis stewardii, Calyx Kaki, Rhizoma Habenariae, Asterias amurensis Lutken, Radix Angelicae Sinensis, Rhizoma Cyperi, alkali ground Chinese small iris, Radix cynanchi wilfordii, Herba veronicae, Pericarpium Citri Reticulatae, Herba Cistanches, Fructus Psoraleae, Castanea seguinii Dode (Involucrum Castaneae Seguinii), Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Fructus Amomi, Delphinium brunonianum Royle, Lignum Santali Albi, crawl volt Viola, Fructus Piperis Longi, le &-Floor, Poria, Ganoderma, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Primula obconica Hance. and Cyananthus argernteus marg..

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 7 ~ 20 parts, Lignum Aquilariae Resinatum 10 ~ 35 parts, Radix potentillae anserinae 12 ~ 38 parts, Radix Morinae Bulleyanae 8 ~ 22 parts, Semen Aesculi 11 ~ 36 parts, Herba Arthraxonis Hispidi 12 ~ 25 parts, Radix Viburni fordiae 13 ~ 28 parts, Rhizoma Zingiberis Preparatum 11 ~ 24 parts, Pericarpium Arecae 14 ~ 23 parts, Herba Thlaspis 12 ~ 34 parts, Fructus Citri Sarcodactylis 15 ~ 37 parts, Rhizoma seu Herba Elatostematis stewardii 10 ~ 35 parts, Calyx Kaki 13 ~ 37 parts, Rhizoma Habenariae 12 ~ 36 parts, Asterias amurensis Lutken 9 ~ 17 parts, Radix Angelicae Sinensis 15 ~ 35 parts, Rhizoma Cyperi 12 ~ 27 parts, alkali ground Chinese small iris 8 ~ 24 parts, Radix cynanchi wilfordii 13 ~ 20 parts, Herba veronicae 11 ~ 17 parts, Pericarpium Citri Reticulatae 9 ~ 20 parts, Herba Cistanches 14 ~ 26 parts, Fructus Psoraleae 10 ~ 37 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 11 ~ 28 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 14 ~ 26 parts, Fructus Amomi 12 ~ 23 parts, Delphinium brunonianum Royle 13 ~ 31 parts, 10 ~ 22 parts, Lignum Santali Albi, crawl volt Viola 10 ~ 23 parts, Fructus Piperis Longi 13 ~ 36 parts, le &-Floor 14 ~ 28 parts, 13 ~ 24 parts, Poria, Ganoderma 14 ~ 34 parts, Radix Pseudostellariae 9 ~ 21 parts, the Rhizoma Atractylodis Macrocephalae 12 ~ 26 parts, Primula obconica Hance. 8 ~ 22 parts and Cyananthus argernteus marg. 11 ~ 32 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 9 ~ 20 parts, Lignum Aquilariae Resinatum 12 ~ 32 parts, Radix potentillae anserinae 13 ~ 35 parts, Radix Morinae Bulleyanae 10 ~ 20 parts, Semen Aesculi 13 ~ 33 parts, Herba Arthraxonis Hispidi 15 ~ 25 parts, Radix Viburni fordiae 14 ~ 28 parts, Rhizoma Zingiberis Preparatum 12 ~ 22 parts, Pericarpium Arecae 15 ~ 23 parts, Herba Thlaspis 13 ~ 32 parts, Fructus Citri Sarcodactylis 15 ~ 35 parts, Rhizoma seu Herba Elatostematis stewardii 11 ~ 31 parts, Calyx Kaki 15 ~ 36 parts, Rhizoma Habenariae 13 ~ 34 parts, Asterias amurensis Lutken 9 ~ 15 parts, Radix Angelicae Sinensis 16 ~ 32 parts, Rhizoma Cyperi 14 ~ 24 parts, alkali ground Chinese small iris 9 ~ 23 parts, Radix cynanchi wilfordii 15 ~ 20 parts, Herba veronicae 13 ~ 16 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Herba Cistanches 15 ~ 24 parts, Fructus Psoraleae 12 ~ 35 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 12 ~ 26 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15 ~ 25 parts, Fructus Amomi 15 ~ 22 parts, Delphinium brunonianum Royle 14 ~ 30 parts, 11 ~ 21 parts, Lignum Santali Albi, crawl volt Viola 12 ~ 22 parts, Fructus Piperis Longi 14 ~ 35 parts, le &-Floor 15 ~ 26 parts, 15 ~ 23 parts, Poria, Ganoderma 15 ~ 33 parts, Radix Pseudostellariae 9 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 13 ~ 24 parts, Primula obconica Hance. 8 ~ 20 parts and Cyananthus argernteus marg. 13 ~ 31 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 12 parts, Lignum Aquilariae Resinatum 23 parts, Radix potentillae anserinae 32 parts, Radix Morinae Bulleyanae 18 parts, Semen Aesculi 30 parts, Herba Arthraxonis Hispidi 22 parts, Radix Viburni fordiae 15 parts, Rhizoma Zingiberis Preparatum 21 parts, Pericarpium Arecae 17 parts, Herba Thlaspis 32 parts, Fructus Citri Sarcodactylis 34 parts, Rhizoma seu Herba Elatostematis stewardii 30 parts, Calyx Kaki 23 parts, Rhizoma Habenariae 32 parts, Asterias amurensis Lutken 13 parts, Radix Angelicae Sinensis 31 parts, Rhizoma Cyperi 23 parts, alkali ground Chinese small iris 13 parts, Radix cynanchi wilfordii 16 parts, Herba veronicae 15 parts, Pericarpium Citri Reticulatae 20 parts, Herba Cistanches 17 parts, Fructus Psoraleae 33 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 24 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 21 parts, Fructus Amomi 16 parts, Delphinium brunonianum Royle 28 parts, 20 parts, Lignum Santali Albi, crawl volt Viola 19 parts, Fructus Piperis Longi 32 parts, le &-Floor 24 parts, 20 parts, Poria, Ganoderma 31 parts, Radix Pseudostellariae 12 parts, the Rhizoma Atractylodis Macrocephalae 22 parts, Primula obconica Hance. 10 parts and Cyananthus argernteus marg. 30 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 18 parts, Lignum Aquilariae Resinatum 22 parts, Radix potentillae anserinae 35 parts, Radix Morinae Bulleyanae 10 parts, Semen Aesculi 33 parts, Herba Arthraxonis Hispidi 25 parts, Radix Viburni fordiae 28 parts, Rhizoma Zingiberis Preparatum 21 parts, Pericarpium Arecae 16 parts, Herba Thlaspis 30 parts, Fructus Citri Sarcodactylis 35 parts, Rhizoma seu Herba Elatostematis stewardii 30 parts, Calyx Kaki 34 parts, Rhizoma Habenariae 28 parts, Asterias amurensis Lutken 11 parts, Radix Angelicae Sinensis 22 parts, Rhizoma Cyperi 15 parts, alkali ground Chinese small iris 13 parts, Radix cynanchi wilfordii 20 parts, Herba veronicae 15 parts, Pericarpium Citri Reticulatae 20 parts, Herba Cistanches 24 parts, Fructus Psoraleae 34 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 25 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 17 parts, Fructus Amomi 20 parts, Delphinium brunonianum Royle 26 parts, 13 parts, Lignum Santali Albi, crawl volt Viola 17 parts, Fructus Piperis Longi 34 parts, le &-Floor 22 parts, 16 parts, Poria, Ganoderma 31 parts, Radix Pseudostellariae 9 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Primula obconica Hance. 20 parts and Cyananthus argernteus marg. 25 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 9 parts, Lignum Aquilariae Resinatum 32 parts, Radix potentillae anserinae 34 parts, Radix Morinae Bulleyanae 20 parts, Semen Aesculi 33 parts, Herba Arthraxonis Hispidi 22 parts, Radix Viburni fordiae 26 parts, Rhizoma Zingiberis Preparatum 13 parts, Pericarpium Arecae 21 parts, Herba Thlaspis 30 parts, Fructus Citri Sarcodactylis 33 parts, Rhizoma seu Herba Elatostematis stewardii 29 parts, Calyx Kaki 36 parts, Rhizoma Habenariae 17 parts, Asterias amurensis Lutken 13 parts, Radix Angelicae Sinensis 31 parts, Rhizoma Cyperi 23 parts, alkali ground Chinese small iris 11 parts, Radix cynanchi wilfordii 18 parts, Herba veronicae 15 parts, Pericarpium Citri Reticulatae 10 parts, Herba Cistanches 24 parts, Fructus Psoraleae 34 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 25 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 22 parts, Fructus Amomi 17 parts, Delphinium brunonianum Royle 27 parts, 13 parts, Lignum Santali Albi, crawl volt Viola 20 parts, Fructus Piperis Longi 34 parts, le &-Floor 24 parts, 21 parts, Poria, Ganoderma 31 parts, Radix Pseudostellariae 13 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Primula obconica Hance. 15 parts and Cyananthus argernteus marg. 15 parts.

Wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Wherein, when the dosage form of described medicine is syrup, its preparation method comprises the following steps:

The first step, by Rhizoma Habenariae, Asterias amurensis Lutken, Radix Angelicae Sinensis, Rhizoma Cyperi, alkali ground Chinese small iris, Radix cynanchi wilfordii, Herba veronicae, Pericarpium Citri Reticulatae, Herba Cistanches and Fructus Psoraleae mix in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder,

Second step, Semen Aesculi, Herba Arthraxonis Hispidi, Radix Viburni fordiae, Rhizoma Zingiberis Preparatum, Pericarpium Arecae, Herba Thlaspis, Fructus Citri Sarcodactylis and Rhizoma seu Herba Elatostematis stewardii are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3% or paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.

Wherein, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

The invention has the beneficial effects as follows: the present invention has warming middle-JIAO and strengthening the spleen; with effect of stomach and alleviating pain; cure mainly spleen-stomach deficiency-cold chronic gastritis; utilize Traditional Chinese medical theory; carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs; specific aim is stronger; the clinical stage different according to disease will carry out " treating the same disease with different methods "; carry out " treating different diseases with the same therapeutic principle " according to similar disease, can eliminating pylorus, protection gastric mucosa; dispersing cold for relieving pain; improve animal economy immunity, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

Chinese medicine is thought, chronic gastritis is that diet injures one's stomach due to diseases caused by exogenous pathogenic factor cold-evil, and feelings will is unsuccessful, weakness of the spleen and stomach, and caused by the cause of disease such as the stagnation of QI, blood stasis, phlegm retention.Basic pathogenesis is gastric qi retardance, and stomach network stasis blocking, stomach is become homeless foster, stagnation of QI and blood may bring about pain.At the beginning of primary disease, pathogenesis is comparatively simple, mostly is cold-evil visitor stomach, retention of food and drink, hyperactive liver-QI attacking the stomach, syndrome of liver-stomach heat, damp-heat in the spleen and stomach etc., true card; Of a specified duration then often Sthenia is transforming into asthenia, and see Deficiency and coldness of spleen and stomach, deficiency of stomach-Yin etc., belong to deficiency syndrome.Also there is the onset person that namely sees Deficiency and coldness of spleen and stomach, also belong to deficiency syndrome.Sick for a long time because causing void in fact, or excess caused by deficiency, and many factors influences each other, and can form cold and heat and asthenia and sthenia and the complicated syndrome of seeing.Dialectical aspect to distinguish cold, hot, empty, real, and be main points at gas, at blood, normal in method for the treatment of is basic principle with Activating Qi and regulating stomach to relieve pain.

Therefore, the invention provides a kind of medicine for the treatment of spleen-stomach deficiency-cold chronic gastritis, with warming middle-JIAO and strengthening the spleen, be primary treatment principle with stomach and alleviating pain, wherein, comprise following raw medicinal material: Fructus Citri tangerinae is red, Lignum Aquilariae Resinatum, Radix potentillae anserinae, Radix Morinae Bulleyanae, Semen Aesculi, Herba Arthraxonis Hispidi, Radix Viburni fordiae, Rhizoma Zingiberis Preparatum, Pericarpium Arecae, Herba Thlaspis, Fructus Citri Sarcodactylis, Rhizoma seu Herba Elatostematis stewardii, Calyx Kaki, Rhizoma Habenariae, Asterias amurensis Lutken, Radix Angelicae Sinensis, Rhizoma Cyperi, alkali ground Chinese small iris, Radix cynanchi wilfordii, Herba veronicae, Pericarpium Citri Reticulatae, Herba Cistanches, Fructus Psoraleae, Castanea seguinii Dode (Involucrum Castaneae Seguinii), Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Fructus Amomi, Delphinium brunonianum Royle, Lignum Santali Albi, crawl volt Viola, Fructus Piperis Longi, le &-Floor, Poria, Ganoderma, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Primula obconica Hance. and Cyananthus argernteus marg..

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Lignum Aquilariae Resinatum: pungent, bitter, temperature; Return spleen, stomach, kidney, lung meridian." Japan hanako materia medica ": " in tune, tonifying five ZANG-organs, nourishing essence and tonifying YANG, warm waist knee joint, uncharm gas.Ending tendon transfer, vomiting and diarrhoea, cold air, broken disease addiction, (controlling) cold wind is benumbed, and joint is not appointed, and wet wind skin is itched, cardiac and abdominal pain, diarrhea due to disorder of qi." Compendium of Material Medica: " control heat in the upper and cold in the lower, QI rising in reverse order is panted, and asthenia of the large intestine closes, urine qi stranguria, man's cold sperm." " book on Chinese herbal medicine is newly organized ": " feeble QI temperature, sun is also, nontoxic for Lignum Aquilariae Resinatum, acrid in the mouth.Enter the gate of vitality.Mend fire mutually, press down cloudy supporing yang, support all gas, exceedingly high ability, control vomiting and diarrhoea, draw Zang Shengong under kidney fire, the gas of peace vomiting, on lead in heart, be the quality goods of heart kidney handing-over.Again temperature and not hot, can commonly use with Yiyang person also.”

Semen Aesculi: warm in nature, sweet in the mouth; Return liver, stomach warp." detailed outline is picked up any lost article from the road ": " the inherited from one's ancestors side of Pueraria lobota, controls heart cold syndrome of the stomach pain, worm pain.The alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, controls gastral cavilty liver diaphragm and expands, infantile malnutrition malaria dysentery, haematemesis impairment caused by overstrain, flat stomach dredging collateral." regulating the flow of QI to ease the stomach, and stomach and alleviating pain., gastralgia vexed for breast abdominal distention.

Rhizoma Zingiberis Preparatum: nature and flavor are bitter, puckery, temperature.Pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian." Elementary Medicine ": " warming the spleen stomach, control interior cold water and let out, dysentery intestinal is warded off, chronic malaria, cholera, trusted subordinate's cold type of pain distension, only epistaxis, hemoptysis, dysentery, metrorrhagia." warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding.For Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tell nosebleed metrorrhagia, yang deficiency is lost blood.Hemorrhage and clotting time can be shortened significantly, all have inhibitory action to the gastric ulcer that irritability and Pylorus Ligated Gastric Ulcer, acetic acid bring out.The pungent dry property of Rhizoma Zingiberis Preparatum is weak compared with Rhizoma Zingiberis, and the power of warming the interior is swift and violent not as Rhizoma Zingiberis, but effect relaxes lastingly, and is longer than warming middle-JIAO to relieve pain, antidiarrheal and warming the meridian for stopping bleeding.

Pericarpium Arecae: acrid in the mouth, slightly warm in nature; Return spleen, stomach, large intestine, small intestine meridian." Kaibao Bencao ": " main cold and hot gas is made a psychological attack abdomen, and large intestine stops up poison, expectorant diaphragm, the belching of acid from stomach.And decoct with Jiang Yantong, enter thin gas medicine good." " detailed outline ": " beriberi is stopped up inverse, subtertian malaria feeling of fullness, nausea malignant histocytosis feeling of distension and oppression for lowering the adverse flow of QI, aqueous vapor edema in the skin that disappears." " property of medicine class is bright ": " and Pericarpium Arecae, Dan Xi conventional to control lung qi dyspnea with rapid and short breath, and in edema medicine again multiplex it, lid is also got it and is let out lung, to kill the source of water also." therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.For retention of damp leading to blockage of QI, breast abdominal distention is vexed, defecates not well, edema, beriberi, dysuria.Rabbits infestines tonicity can be made to raise to the effect Pericarpium Arecae decoct of intestinal smooth muscle, shrinkage amplitude reduces, and its effect can by atropine institute antagonism.

Calyx Kaki: puckery, property is put down, and enters lung, spleen, stomach, large intestine channel.There are clearing heat and moistening lung, promoting the production of body fluid to quench thirst, effect of invigorating the spleen for dissipating phlegm; Be used for the treatment of cough due to lung-heat, thirsty, vomiting, diarrhea.Compendium of Material Medica: " cough with dyspnea person, gas chong channel under umbilicus is directly gone up to swallowing diaphragm, oh make a mistake, not smoothgoing inverse sound also." 0.5% Calyx kaki extract (ST) 50mg/kg lumbar injection in mice, can show and resist the room that chloroform brings out and quiver; Also can resist rat ventricular caused by aconitine, barium chloride, mouse peritoneal is injected, and spontaneous activity is obviously reduced, and strengthens the syngignoscism of sub-threshold dose pentobarbital sodium, extends its length of one's sleep, and the mice straub tail reaction that obvious antagonism morphine causes.

Radix cynanchi wilfordii: this product and Radix Cynanchi Auriculati bitter but sweet flavor puckery, slightly warm in nature, nontoxic; Enter liver, kidney two warp.Nourishing the liver and kidney, strengthening body, nourishes blood and enriches blood, crow palpus hair color, convergence vital essence, promoting tissue regeneration and ulcer healing, loosening bowel to relieve constipation.Control prolonged illness weakness, chronic migratory arthralgia, soreness of the waist and knees, anemia, enterorrhagia, early whitening of beard and hair, neurasthenia, deficiency of YIN chronic malaria, ulcer does not close up for a long time, old people constipation.

Herba Cistanches: sweet, salty, temperature; Return kidney, large intestine channel." property of medicine opinion ": " beneficial marrow, improving healthy complexion, prolongs life, and controls woman's metrorrhagia, tonifying YANG, large tonification, main red white under." " Japan hanako materia medica ": " control male-sterilisation sun out of fashion, female is exhausted, and the moon does not produce, moistening five ZANG-organs, longue meat, warm waist knee joint, and man lets out essence, hematuria, loses drop, leukorrhagia pain over the perineum." kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.Herba Cistanches contains the compositions such as abundant alkaloid, crystalline neutral substance, aminoacid, trace element, vitamin.Can kidney-replenishing, benefiting essence-blood, can suppress the appearance of " yang deficiency " symptom, the disease such as prevent from losing weight and woman's menoxenia, amenorrhea be infertile.Herba Cistanches decoct 10g/kg gavage, can strengthen the function of rat hypothalamus-pituitary and ovary, improves hypophysis to the reactivity of luteinizing hormone releasing hormone and ovary to the reactivity of lutropin, and does not affect the incretion balance in natural reproduction cycle.Water-leach liquor, alcohol-water leachate and alcohol leaching liquid have hypotensive effect to anesthetized dog, cat, rabbit etc.

Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, return kidney, spleen channel." property of medicine opinion ": " main man's pain in the lumbar region, the cold capsule of knee joint wets, stupid by all cold numbness, and only normal urination, cold in abdomen." " Kaibao Bencao ": " bone marrow wound loses for main five kinds of strain and seven kinds of impairment, wind cold caused by deficiency, the cold essence stream of kidney and the induced abortion of married woman's vim and vigour." kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.Be used for the treatment of impotence due to deficiency of the kidney, soreness of the waist and knees cold type of pain, emission due to deficiency of the kidney, the enuresis, frequent micturition, the Diarrhoea that deficiency of spleen-YANG and kidneyYANG causes.The deficiency and coldness of failure of the kidney in receiving QI is breathed with cough.Act on the contiguous destruction not yet completely of damaged cell or normal melanocyte after medication, tyrosinase activity is increased, promotes melanin genesis.Fructus Psoraleae has obvious diastole effect to the airway constriction caused by histamine, the strongest with effect in 15 minutes after dosing, but is slightly inferior to aminophylline, two groups compared with blank group spasmolysis, difference highly significant." Bencao Jingshu ": " all sick deficiency of YIN fire are dynamic, nocturnal emission, hematuria, and the puckery and order also bitter taste dry tongue of oliguria, constipation due to dry stool, interior hotwork is thirsty, and fire rises conjunctival congestion, and easily famine is noisy, and damp and hot one-tenth flaccidity, so that the weary unable person of bone, neither should take.”

Fructus Piperis Longi: pungent, heat.Return spleen channel, stomach warp, large intestine channel, lung meridian, urinary bladder channel, Liver Channel, kidney channel.Warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomit, have loose bowels, the toothache of migraine, nasal sinusitis, external treatment, coronary heart diseases and angina pectoris.Control trusted subordinate's cold type of pain, vomiting acid regurgitation, increased borborygmus and diarrhea, cold-dysentery, scrotal hernia, headache, nasal sinusitis, toothache.Volatile oil contained by these product to staphylococcus aureus, bacillus subtilis, Bacillus cereus, tubercule bacillus, dysentery bacterium, salmonella typhi T and B, yolk color eight folds bacterium etc. and influenza virus all has inhibitory action.Fructus Piperis Longi volatile oil can improve the hypoxia-bearing capability of mice under reduced pressure, Fructus Piperis Longi oil unsaponifiable matter significantly can also reduce the endogenous hypercholesterolemia mice serum T-CHOL and hepatic cholesterol content that feed 5% Adeps Sus domestica feedstuff brings out, the rising of the mice serum T-CHOL significantly suppressing Triton to bring out.

Poria: sweet, light is flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, inducing QI of promoting the production of body fluid." modern study shows that the effect that Poria has an enhancing immunity can many-sided regulate immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.

Ganoderma: sweet, flat.GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote that liver is to the metabolism of medicine, poisonous substance, has definite curative effect for toxic hepatitis.Zoopery and clinical trial all show, Ganoderma can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is protective effect, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.Polysaccharide contained by Ganoderma, polypeptide etc. have obvious function of delaying senility.Extract energy exciting motion suppresses, mobility is reduced, coordination exercise is lacked of proper care, presents the sick effect in dose-dependent town, can curtail sleep to hexobarbital sleep effect, the time that central stimulants caffeine causes spasm and death can be extended, these results show, Ganoderma is inhibition effect to maincenter.

Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and returns spleen, lung meridian, " book on Chinese herbal medicine is new again ": " control the deficiency of vital energy dryness of the lung, spleen reinforcing soil, consumer edema, reduces phlegm and quench the thirst." " Shaanxi Chinese herbal medicine ": " invigorating qi and benefiting blood, spleen invigorating is promoted the production of body fluid.After curing the disease, body is empty, cough due to deficiency of the lung, insufficiency of the spleen diarrhoea, children's's sweating due to debility, cardiopalmus, xerostomia, anorexia." there is effect of air making-up and spleen enlivening, the lung moistening and production of body fluid promoting, cure mainly the inappetence caused by deficiency-weakness of spleen-QI, fatigue and weakness, deficiency of the lung cough caused by dryness, dyspnea with rapid and short breath is breathed hard, the convalescent stage of febrile disease, and gas Tianjin two is hindered, and interior-heat is thirsty waits card.Can QI invigorating, again can YIN nourishing and the production of body fluid promoting, and the efficacy of a drug is gentle, be the product of clear benefits simply, be applicable to spleen lung virtual loss, deficiency of both vital energy and Yin, all diseases of gas Tianjin deficiency.Radix Pseudostellariae has obvious stimulation to lymphocyte.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.There is obvious and lasting diuresis, to various animal as rat, rabbit, Canis familiaris L. have effect.To not anaesthetizing Canis familiaris L. intravenous injection decoct 0.05-0.25g/kg, urine volume increase can reach more than 9 times, and medication after 5 hours still higher than normally.The Rhizoma Atractylodis Macrocephalae has obvious inhibitory action to platelet aggregation, Rhizoma Atractylodis Macrocephalae decoct 0.5g/kg gavage l-4 week, the time of energy significant prolongation rat prothrombing.The Rhizoma Atractylodis Macrocephalae has vasorelaxation action.Be inhibitory action to heart, can cause when dosage is excessive and stop winning, anesthetized dog intravenous injection decoct 0.1g/kg, blood pressure slightly decline 0.25g/kg time, blood pressure sharply declines, and has no recovery in 3-4 hour.

Delphinium brunonianum Royle: nature and flavor: bitter, puckery, cold.Cure mainly: removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching.Cure mainly influenza, itchy skin eruption, the diseases such as venom.

Climbing Viloet Herb: nature and flavor: bitter, micro-pungent, cold.Cure mainly: heat-clearing and toxic substances removing, detumescence and apocenosis.For hepatitis, pertussis, conjunctival congestion and swelling pain; Acute mastitis is controlled in external, furuncle, carbuncle furuncle, herpes zoster, venom, traumatic injury.

Herba veronicae: nature and flavor: light is cool.Cure mainly: cooling blood for hemostasis, regulating QI to relieve pain.For spitting blood, hernia, orchitis, leucorrhea.

Alkali ground Chinese small iris: nature and flavor: sweet, light, cool.Cure mainly: heat-clearing and toxic substances removing, diuresis, hemostasis.

Castanea seguinii Dode (Involucrum Castaneae Seguinii): cure mainly: control pneumonia, pulmonary tuberculosis, erysipelas, sore.

Primula obconica Hance.: nature and flavor: bitter; Cool in nature.Gui Jing: spleen, stomach two warp.Cure mainly: alcoholic intoxication; Only stomachache.Master is addicted to drink immoderate; The alcoholism impairment of the spleen; Stomachache is just let out.

Herba Thlaspis: nature and flavor: herb: bitter, sweet, flat.Seed: pungent, bitter, tepor.Cure mainly: herb: heat-clearing and toxic substances removing, inducing diuresis and reducing edema, and middle appetizing.For appendicitis, lung abscess, carbuncle furuncle and phyma poison, erysipelas, endometritis, leucorrhea, nephritis, cirrhotic ascites, infantile dyspepsia.Seed: expelling wind and removing dampness, and stomach and alleviating pain.For rheumatic arthritis, lumbago, acute conjunctivitis, stomachache, hepatitis.

Lignum Santali Albi: nature and flavor: pungent, temperature.Gui Jing: return spleen, stomach, the heart, lung meridian.Cure mainly: circulation of qi promoting warming middle-JIAO, appetizing pain relieving.For QI stagnated by cold, chest pain, stomachache, stomachache lack of appetite; Coronary heart disease, angina pectoris.

Rhizoma seu Herba Elatostematis stewardii: source: " Nanning City's medicine will ".Another name: red hen medicine (" Nanning City's medicine will "), red hair hen, Folium Allii tuberosi (" register planted by Guangxi medicine ").Nature and flavor: bitter are flat.Cure mainly: promoting tissue regeneration by removing blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral.Infusing drugs in wine takes, the strong muscles and bones of energy, dispelling the wind and dampness pathogens osteodynia.Leaf controls traumatic injury, synthetism.

Herba Arthraxonis Hispidi: nature and flavor: bitter is flat.Cure mainly: heat clearing away, sending down the abnormal ascending QI, relieving cough and asthma, removing toxic substances, Eradicates rheumatism.Cure mainly hepatitis, chronic cough is panted, pharyngolaryngitis, stomatitis, rhinitis, lymphadenitis, mastitis.Scabies is controlled in external, skin pruritus, carbuncle furuncle.

Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Fructus Amomi: nature and flavor: pungent, temperature.Gui Jing: return spleen, stomach, kidney channel.Cure mainly: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus): nature and flavor: pungent, bitter, temperature.Cure mainly: really: invigorating the stomach and promoting digestion, regulating QI to relieve pain.For stomachache, dyspepsia, chest and abdomen swelling and pain, constipation, uterine prolapse, proctoptosis, painful and swollen testis, colic.Leaf: promote qi circulation digestion promoting, preventing or arresting vomiting.For regurgitation, vomiting.

Rhizoma Habenariae: nature and flavor: sweet, light is flat.Cure mainly: tonify deficiency, stomach invigorating strengthening the spleen.Cure mainly body void, young waiter in a wineshop or an inn's dyspepsia, diarrhoea, rheumatic arthritis.

Fructus Citri Sarcodactylis: nature and flavor: pungent, bitter, sour, temperature.Gui Jing: return liver, spleen, lung meridian.Cure mainly: liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.

Radix Viburni fordiae: nature and flavor: bitter, cool.Cure mainly: expelling wind and clearing away heat, removing blood stasis and activating blood flow.Flu, heating, menoxenia.

Radix Morinae Bulleyanae: nature and flavor: sweet, micro-hardship, temperature.Cure mainly: fill blood, connect muscles and bones.For neurosis, anemia, cough due to deficiency of the lung, dyspepsia, leukorrhagia, uterine prolapse; Traumatic injury is controlled in external.

Radix potentillae anserinae: nature and flavor: sweet is flat.Cure mainly: fill blood, strengthening the spleen and stomach, promoting the production of body fluid to quench thirst, dampness removing.For anemia after being ill, malnutrition, insufficiency of the spleen diarrhoea, rheumatic arthralgia.

Le &-Floor: another name: Canis familiaris L. Pericarpium Zanthoxyli, Radix Zanthoxyli Avicennae [Fujian, Guangdong], chicken &-Floor, seed of Zanthoxylum armatum DC.(Z.Planispinum Sieb.et Zucc.) [Hainan], Zanthoxylum avicennae, Ramulus Kalopanacis seu Araliae [Guangdong, Guangxi] recklessly.Source: Rutaceae xanthoxylum Zanthoxylum avicennae (Lam.) DC., is used as medicine with root, leaf and fruit.Root can be adopted the whole year; Leaf can be adopted at any time; Fruit is adopted winter, dries.Nature and flavor: bitter, pungent, tepor.Cure mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain.Root: icterohepatitis, oedema due to nephritis, rheumatic arthritis.Really: stomachache, stomachache.Leaf: traumatic injury, lumbar muscle strain, mastitis, furuncle and phyma.Le &-Floor Fructus Aurantii: nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Cure mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.

Cyananthus argernteus marg.: nature and flavor: sweet, bitter, temperature.Cure mainly: spleen invigorating dehumidifies, dredge the meridian passage.Cure mainly children's's breast poison (eating place milk) diarrhoea, rheumatalgia, traumatic injury.

Asterias amurensis Lutken: nature and flavor: salty in the mouth; Property is put down.Gui Jing: the heart; Stomach; Large intestine channel.Cure mainly: detoxicating and resolving stagnation of pathogens; And stomach and alleviating pain.Main thyromegaly; Scrofula; Stomachache pantothenic acid; Diarrhoea otitis media.

Rhizoma Cyperi: nature and flavor: pungent, micro-hardship, micro-sweet, flat.Gui Jing: return liver, spleen, tri-jiao channel.Cure mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.

Pericarpium Citri Reticulatae: nature and flavor: bitter, pungent, temperature.Gui Jing: return lung, spleen channel.Cure mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Exocarpium Citri Rubrum: nature and flavor: pungent, bitter, temperature.Gui Jing: return lung, spleen channel.Cure mainly: cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.

Embodiment 1 capsule

The manufacturing process of capsule of the present invention is: get Exocarpium Citri Rubrum 120g, Lignum Aquilariae Resinatum 230g, Radix potentillae anserinae 320g, Radix Morinae Bulleyanae 180g, Semen Aesculi 300g, Herba Arthraxonis Hispidi 220g, Radix Viburni fordiae 150g, Rhizoma Zingiberis Preparatum 210g, Pericarpium Arecae 170g, Herba Thlaspis 320g, Fructus Citri Sarcodactylis 340g, Rhizoma seu Herba Elatostematis stewardii 300g, Calyx Kaki 230g, Rhizoma Habenariae 320g, Asterias amurensis Lutken 130g, Radix Angelicae Sinensis 310g, Rhizoma Cyperi 230g, alkali ground Chinese small iris 130g, Radix cynanchi wilfordii 160g, Herba veronicae 150g, Pericarpium Citri Reticulatae 200g, Herba Cistanches 170g, Fructus Psoraleae 330g, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 240g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 210g, Fructus Amomi 160g, Delphinium brunonianum Royle 280g, Lignum Santali Albi 200g, crawl volt Viola 190g, Fructus Piperis Longi 320g, le &-Floor 240g, Poria 200g, Ganoderma 310g, Radix Pseudostellariae 120g, Rhizoma Atractylodis Macrocephalae 220g, Primula obconica Hance. 100g and Cyananthus argernteus marg. 300g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.5:0.3, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 2 syrup

The manufacturing process of syrup of the present invention is: get Exocarpium Citri Rubrum 180g, Lignum Aquilariae Resinatum 220g, Radix potentillae anserinae 350g, Radix Morinae Bulleyanae 100g, Semen Aesculi 330g, Herba Arthraxonis Hispidi 250g, Radix Viburni fordiae 280g, Rhizoma Zingiberis Preparatum 210g, Pericarpium Arecae 160g, Herba Thlaspis 300g, Fructus Citri Sarcodactylis 350g, Rhizoma seu Herba Elatostematis stewardii 300g, Calyx Kaki 340g, Rhizoma Habenariae 280g, Asterias amurensis Lutken 110g, Radix Angelicae Sinensis 220g, Rhizoma Cyperi 150g, alkali ground Chinese small iris 130g, Radix cynanchi wilfordii 200g, Herba veronicae 150g, Pericarpium Citri Reticulatae 200g, Herba Cistanches 240g, Fructus Psoraleae 340g, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 250g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 170g, Fructus Amomi 200g, Delphinium brunonianum Royle 260g, Lignum Santali Albi 130g, crawl volt Viola 170g, Fructus Piperis Longi 340g, le &-Floor 220g, Poria 160g, Ganoderma 310g, Radix Pseudostellariae 90g, Rhizoma Atractylodis Macrocephalae 130g, Primula obconica Hance. 200g and Cyananthus argernteus marg. 250g,

The first step, Rhizoma Habenariae, Asterias amurensis Lutken, Radix Angelicae Sinensis, Rhizoma Cyperi, alkali ground Chinese small iris, Radix cynanchi wilfordii, Herba veronicae, Pericarpium Citri Reticulatae, Herba Cistanches and Fructus Psoraleae are mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 90%, heating and refluxing extraction 3 times, each reflux, extract, 2 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the medicinal liquid of 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 200 orders subsequently, obtain dry powder;

Second step, Semen Aesculi, Herba Arthraxonis Hispidi, Radix Viburni fordiae, Rhizoma Zingiberis Preparatum, Pericarpium Arecae, Herba Thlaspis, Fructus Citri Sarcodactylis and Rhizoma seu Herba Elatostematis stewardii being mixed in described ratio, be ground into powder, is that the ethanol of 85% is as solvent with determining alcohol, flood 72 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.27, dry with spray dryer, be ground into 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;

3rd step, remaining raw medicinal material is mixed in described ratio, add relative to mixture 5 times amount determining alcohol be 75% alcohol reflux 3 times, each 2 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.21, in 60 DEG C of reduced vacuum dryings, obtains dry powder;

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.2% or paraben preservative are as ethyl hydroxybenzoate 0.05%.

Embodiment 3 tablet

The manufacturing process of Tablets is: get Exocarpium Citri Rubrum 90g, Lignum Aquilariae Resinatum 320g, Radix potentillae anserinae 340g, Radix Morinae Bulleyanae 200g, Semen Aesculi 330g, Herba Arthraxonis Hispidi 220g, Radix Viburni fordiae 260g, Rhizoma Zingiberis Preparatum 130g, Pericarpium Arecae 210g, Herba Thlaspis 300g, Fructus Citri Sarcodactylis 330g, Rhizoma seu Herba Elatostematis stewardii 290g, Calyx Kaki 360g, Rhizoma Habenariae 170g, Asterias amurensis Lutken 130g, Radix Angelicae Sinensis 310g, Rhizoma Cyperi 230g, alkali ground Chinese small iris 110g, Radix cynanchi wilfordii 180g, Herba veronicae 150g, Pericarpium Citri Reticulatae 100g, Herba Cistanches 240g, Fructus Psoraleae 340g, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 250g, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 220g, Fructus Amomi 170g, Delphinium brunonianum Royle 270g, Lignum Santali Albi 130g, crawl volt Viola 200g, Fructus Piperis Longi 340g, le &-Floor 240g, Poria 210g, Ganoderma 310g, Radix Pseudostellariae 130g, Rhizoma Atractylodis Macrocephalae 200g, Primula obconica Hance. 150g and Cyananthus argernteus marg. 150g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.04 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.

Toxicity test:

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 3 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: the syrup of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch and come from routine spleen-stomach deficiency-cold Patients with Chronic Gastritis in the court's April-2012 years in April, 2,011 296, male 165 people, female 131 people; 35 ~ 68 years old age, average (43.7 ± 10.9) year.Medical history 5 months ~ 7 years.All cases is all made a definite diagnosis through gastroscope.296 routine patients are divided into for capsule treatment group, syrup treatment group, tablet in treatment group and matched group at random, each experimental group 74 people.

Diagnostic criteria: (1) gastral cavilty portion pain, the disease such as the vexed or distension of normal companion's painful abdominal mass, belch, pantothenic acid, noisy, nausea and vomiting.(2) morbidity normal with feelings will not freely, eating and drinking without temperance, fatigue, the factor such as to catch cold be relevant.(3) upper digestive tract barium meal x-ray inspection, fibergastroscope and histopathology biopsy etc., the pathological changes such as visible Gastroduodenal mucosal lesions inflammation, ulcer.(4) stool or vomitus occult blood test strong positive person, prompting Complicated by Hemorrhage of Digestive Tract '.(5) B ultrasonic, liver function, angiocholegraphy contribute to Differential Diagnosis.And hope according to the traditional Chinese medical science, hear, ask, cut and be dialectically diagnosed as spleen-stomach deficiency-cold chronic gastritis further.

Therapeutic Method:

In medication therapy groups:

Capsule treatment group: take the embodiment of the present invention 1 prepare capsule, every day 3 times, one time 2, within every 30 days, be 1 course for the treatment of;

Syrup treatment group: take syrup prepared by the embodiment of the present invention 2, every day 3 times, 30ml/ time every 30 days is a course for the treatment of;

Tablet in treatment group: take tablet prepared by the embodiment of the present invention 3, every day 3 times, each 2 every 30 days is a course for the treatment of.

Matched group: take bismuth citrate k particle, every day 3 times, each 1 bag, every bag of 12g every 30 days is a course for the treatment of.

The standard of curative effect evaluation:

Recovery from illness: symptom complete incidence graph after treatment, gastroscopy inflammation disappears; Effective: after treatment, comparatively the front symptom for the treatment of obviously alleviates, and stomachoscopy inflammation disappears substantially; Effective: after treatment, comparatively symptom alleviates or obviously alleviates before treatment, and gastroscopy inflammation has and alleviates; Invalid: after treatment, comparatively treatment is front unchanged, and gastroscopy is unchanged or serious on the contrary.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy spleen-stomach deficiency-cold chronic gastritis of the present invention, relative to the medicine of matched group on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy spleen-stomach deficiency-cold chronic gastritis of the present invention, relative to the medicine of matched group, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Recovery from illness number	Effective number	Significant figure	Invalid number	Total effective rate (%)
							Capsule treatment group	74	29	31	13	1	98.6％
Syrup treatment group	74	29	30	15	0	100％
							Tablet in treatment group	74	27	32	15	0	100％
Matched group	74	11	19	29	15	79.7％

Table 2 Four composition does not treat recovery from illness after 4 courses for the treatment of, effective and efficiently individual quantity and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Capsule treatment group	73	15（20.5％）	18（24.7％）	19（26％）	21（28.8％）
Syrup treatment group	74	15（20.3％）	17（23％）	19（25.7％）	23（31.1％）
						Tablet in treatment group	74	14（18.9％）	18（24％）	20（27％）	22（30％）
Matched group	59	6（10.2％）	10（16.9％）	13（22％）	30（50.8％）

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Simultaneously to 221 examples for the treatment of group recovery from illness, effective and efficiently individual quantity and matched group recovery from illness, effective and effective 59 routine follow-up of patients 1 year half, result is added up, in capsule treatment group 73 example, recovery from illness 29 example and effective 31 examples are all without recurrence, 1 case relapsed in effective 13 examples, and relapse rate is 1.4%; 29 examples fully recover in syrup treatment group 74 example without recurrence, 1 case relapsed in effective 30 examples, 1 case relapsed in effective 15 examples, and relapse rate is 2.7%; 27 examples fully recover in tablet in treatment group 74 example without recurrence, 1 case relapsed in effective 32 examples, 1 case relapsed in effective 15 examples, and relapse rate is 2.7%; The recovery from illness of matched group group, effective and efficiently individual quantity 59 example, 1 case relapsed in 11 routine patients of recovery from illness, recurs 7 examples in effective 19 routine patients, recur 14 examples, relapse rate 37.3% in effective 29 examples; Above-mentioned recurrence refer to patient outcomes reach recovery from illness more, effective or effectively after, in 1 year half of following up a case by regular visits to, obviously occur that the painful abdominal mass before treatment is vexed, belch, pantothenic acid, the symptom such as noisy, nausea and vomiting.

Model case: Wang; women; 48 years old; gastral cavilty portion pain half a year; often can the disease such as, belch, pantothenic acid vexed with painful abdominal mass, noisy, nausea and vomiting, to check through upper digestive tract barium meal x-ray, fibergastroscope and histopathology biopsy etc., visible Gastroduodenal mucosal lesions inflammatory disorders; be diagnosed as chronic gastritis, then hope according to the traditional Chinese medical science, hear, ask, cut and be diagnosed as spleen-stomach deficiency-cold chronic gastritis further.Take the tablet of the embodiment of the present invention 3, every day 3 times, each 2, treat and substantially cure for 2 months, continue two weeks healing of taking medicine, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of spleen-stomach deficiency-cold chronic gastritis for one kind, it is characterized in that, comprise following raw medicinal material: Exocarpium Citri Rubrum, Lignum Aquilariae Resinatum, Radix potentillae anserinae, Radix Morinae Bulleyanae, Semen Aesculi, Herba Arthraxonis Hispidi, Radix Viburni fordiae, Rhizoma Zingiberis Preparatum, Pericarpium Arecae, Herba Thlaspis, Fructus Citri Sarcodactylis, Rhizoma seu Herba Elatostematis stewardii, Calyx Kaki, Rhizoma Habenariae, Asterias amurensis Lutken, Radix Angelicae Sinensis, Rhizoma Cyperi, alkali ground Chinese small iris, Radix cynanchi wilfordii, Herba veronicae, Pericarpium Citri Reticulatae, Herba Cistanches, Fructus Psoraleae, Castanea seguinii Dode (Involucrum Castaneae Seguinii), Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Fructus Amomi, Delphinium brunonianum Royle, Lignum Santali Albi, crawl volt Viola, Fructus Piperis Longi, le &-Floor, Poria, Ganoderma, Radix Pseudostellariae, the Rhizoma Atractylodis Macrocephalae, Primula obconica Hance. and Cyananthus argernteus marg..

2. the medicine for the treatment of spleen-stomach deficiency-cold chronic gastritis according to claim 1, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 7 ~ 20 parts, Lignum Aquilariae Resinatum 10 ~ 35 parts, Radix potentillae anserinae 12 ~ 38 parts, Radix Morinae Bulleyanae 8 ~ 22 parts, Semen Aesculi 11 ~ 36 parts, Herba Arthraxonis Hispidi 12 ~ 25 parts, Radix Viburni fordiae 13 ~ 28 parts, Rhizoma Zingiberis Preparatum 11 ~ 24 parts, Pericarpium Arecae 14 ~ 23 parts, Herba Thlaspis 12 ~ 34 parts, Fructus Citri Sarcodactylis 15 ~ 37 parts, Rhizoma seu Herba Elatostematis stewardii 10 ~ 35 parts, Calyx Kaki 13 ~ 37 parts, Rhizoma Habenariae 12 ~ 36 parts, Asterias amurensis Lutken 9 ~ 17 parts, Radix Angelicae Sinensis 15 ~ 35 parts, Rhizoma Cyperi 12 ~ 27 parts, alkali ground Chinese small iris 8 ~ 24 parts, Radix cynanchi wilfordii 13 ~ 20 parts, Herba veronicae 11 ~ 17 parts, Pericarpium Citri Reticulatae 9 ~ 20 parts, Herba Cistanches 14 ~ 26 parts, Fructus Psoraleae 10 ~ 37 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 11 ~ 28 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 14 ~ 26 parts, Fructus Amomi 12 ~ 23 parts, Delphinium brunonianum Royle 13 ~ 31 parts, 10 ~ 22 parts, Lignum Santali Albi, crawl volt Viola 10 ~ 23 parts, Fructus Piperis Longi 13 ~ 36 parts, le &-Floor 14 ~ 28 parts, 13 ~ 24 parts, Poria, Ganoderma 14 ~ 34 parts, Radix Pseudostellariae 9 ~ 21 parts, the Rhizoma Atractylodis Macrocephalae 12 ~ 26 parts, Primula obconica Hance. 8 ~ 22 parts and Cyananthus argernteus marg. 11 ~ 32 parts.

3. the medicine for the treatment of spleen-stomach deficiency-cold chronic gastritis according to claim 1 and 2, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 9 ~ 20 parts, Lignum Aquilariae Resinatum 12 ~ 32 parts, Radix potentillae anserinae 13 ~ 35 parts, Radix Morinae Bulleyanae 10 ~ 20 parts, Semen Aesculi 13 ~ 33 parts, Herba Arthraxonis Hispidi 15 ~ 25 parts, Radix Viburni fordiae 14 ~ 28 parts, Rhizoma Zingiberis Preparatum 12 ~ 22 parts, Pericarpium Arecae 15 ~ 23 parts, Herba Thlaspis 13 ~ 32 parts, Fructus Citri Sarcodactylis 15 ~ 35 parts, Rhizoma seu Herba Elatostematis stewardii 11 ~ 31 parts, Calyx Kaki 15 ~ 36 parts, Rhizoma Habenariae 13 ~ 34 parts, Asterias amurensis Lutken 9 ~ 15 parts, Radix Angelicae Sinensis 16 ~ 32 parts, Rhizoma Cyperi 14 ~ 24 parts, alkali ground Chinese small iris 9 ~ 23 parts, Radix cynanchi wilfordii 15 ~ 20 parts, Herba veronicae 13 ~ 16 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Herba Cistanches 15 ~ 24 parts, Fructus Psoraleae 12 ~ 35 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 12 ~ 26 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 15 ~ 25 parts, Fructus Amomi 15 ~ 22 parts, Delphinium brunonianum Royle 14 ~ 30 parts, 11 ~ 21 parts, Lignum Santali Albi, crawl volt Viola 12 ~ 22 parts, Fructus Piperis Longi 14 ~ 35 parts, le &-Floor 15 ~ 26 parts, 15 ~ 23 parts, Poria, Ganoderma 15 ~ 33 parts, Radix Pseudostellariae 9 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 13 ~ 24 parts, Primula obconica Hance. 8 ~ 20 parts and Cyananthus argernteus marg. 13 ~ 31 parts.

4. the medicine of the treatment spleen-stomach deficiency-cold chronic gastritis according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 12 parts, Lignum Aquilariae Resinatum 23 parts, Radix potentillae anserinae 32 parts, Radix Morinae Bulleyanae 18 parts, Semen Aesculi 30 parts, Herba Arthraxonis Hispidi 22 parts, Radix Viburni fordiae 15 parts, Rhizoma Zingiberis Preparatum 21 parts, Pericarpium Arecae 17 parts, Herba Thlaspis 32 parts, Fructus Citri Sarcodactylis 34 parts, Rhizoma seu Herba Elatostematis stewardii 30 parts, Calyx Kaki 23 parts, Rhizoma Habenariae 32 parts, Asterias amurensis Lutken 13 parts, Radix Angelicae Sinensis 31 parts, Rhizoma Cyperi 23 parts, alkali ground Chinese small iris 13 parts, Radix cynanchi wilfordii 16 parts, Herba veronicae 15 parts, Pericarpium Citri Reticulatae 20 parts, Herba Cistanches 17 parts, Fructus Psoraleae 33 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 24 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 21 parts, Fructus Amomi 16 parts, Delphinium brunonianum Royle 28 parts, 20 parts, Lignum Santali Albi, crawl volt Viola 19 parts, Fructus Piperis Longi 32 parts, le &-Floor 24 parts, 20 parts, Poria, Ganoderma 31 parts, Radix Pseudostellariae 12 parts, the Rhizoma Atractylodis Macrocephalae 22 parts, Primula obconica Hance. 10 parts and Cyananthus argernteus marg. 30 parts.

5. the medicine of the treatment spleen-stomach deficiency-cold chronic gastritis according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 18 parts, Lignum Aquilariae Resinatum 22 parts, Radix potentillae anserinae 35 parts, Radix Morinae Bulleyanae 10 parts, Semen Aesculi 33 parts, Herba Arthraxonis Hispidi 25 parts, Radix Viburni fordiae 28 parts, Rhizoma Zingiberis Preparatum 21 parts, Pericarpium Arecae 16 parts, Herba Thlaspis 30 parts, Fructus Citri Sarcodactylis 35 parts, Rhizoma seu Herba Elatostematis stewardii 30 parts, Calyx Kaki 34 parts, Rhizoma Habenariae 28 parts, Asterias amurensis Lutken 11 parts, Radix Angelicae Sinensis 22 parts, Rhizoma Cyperi 15 parts, alkali ground Chinese small iris 13 parts, Radix cynanchi wilfordii 20 parts, Herba veronicae 15 parts, Pericarpium Citri Reticulatae 20 parts, Herba Cistanches 24 parts, Fructus Psoraleae 34 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 25 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 17 parts, Fructus Amomi 20 parts, Delphinium brunonianum Royle 26 parts, 13 parts, Lignum Santali Albi, crawl volt Viola 17 parts, Fructus Piperis Longi 34 parts, le &-Floor 22 parts, 16 parts, Poria, Ganoderma 31 parts, Radix Pseudostellariae 9 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Primula obconica Hance. 20 parts and Cyananthus argernteus marg. 25 parts.

6. the medicine of the treatment spleen-stomach deficiency-cold chronic gastritis according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Exocarpium Citri Rubrum 9 parts, Lignum Aquilariae Resinatum 32 parts, Radix potentillae anserinae 34 parts, Radix Morinae Bulleyanae 20 parts, Semen Aesculi 33 parts, Herba Arthraxonis Hispidi 22 parts, Radix Viburni fordiae 26 parts, Rhizoma Zingiberis Preparatum 13 parts, Pericarpium Arecae 21 parts, Herba Thlaspis 30 parts, Fructus Citri Sarcodactylis 33 parts, Rhizoma seu Herba Elatostematis stewardii 29 parts, Calyx Kaki 36 parts, Rhizoma Habenariae 17 parts, Asterias amurensis Lutken 13 parts, Radix Angelicae Sinensis 31 parts, Rhizoma Cyperi 23 parts, alkali ground Chinese small iris 11 parts, Radix cynanchi wilfordii 18 parts, Herba veronicae 15 parts, Pericarpium Citri Reticulatae 10 parts, Herba Cistanches 24 parts, Fructus Psoraleae 34 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 25 parts, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) 22 parts, Fructus Amomi 17 parts, Delphinium brunonianum Royle 27 parts, 13 parts, Lignum Santali Albi, crawl volt Viola 20 parts, Fructus Piperis Longi 34 parts, le &-Floor 24 parts, 21 parts, Poria, Ganoderma 31 parts, Radix Pseudostellariae 13 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Primula obconica Hance. 15 parts and Cyananthus argernteus marg. 15 parts.

7. the preparation method of the medicine of the treatment spleen-stomach deficiency-cold chronic gastritis according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

8. the preparation method of the medicine of the treatment spleen-stomach deficiency-cold chronic gastritis according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is syrup, its preparation method comprises the following steps:

4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 30 ~ 60%, Pyrusussuriensis acids antiseptic 0.1 ~ 0.3% or paraben preservative 0.01 ~ 0.05%.

9. the preparation method of the medicine of the treatment spleen-stomach deficiency-cold chronic gastritis according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps: