CN102784363A

CN102784363A - Traditional Chinese medicine composition for treating pancreatic cancer and preparation method thereof

Info

Publication number: CN102784363A
Application number: CN2012103061898A
Authority: CN
Inventors: 郑美芳; 毕延萍
Original assignee: Individual
Current assignee: Shi Degong
Priority date: 2012-08-17
Filing date: 2012-08-17
Publication date: 2012-11-21
Anticipated expiration: 2032-08-17
Also published as: CN102784363B

Abstract

The invention provides a traditional Chinese medicine composition for treating the pancreatic cancer and a preparation method of the traditional Chinese medicine composition. The medicinal raw materials of the traditional Chinese medicine composition are as follows: herba sarcandrae, zaocys dhumnade, scutellariae barbatae, Chinese lobelia, oldenlandia diffusa, taraxacum mongolicum, herba violae, herba patriniae, flos lonicerae, fructus forsythiae, radix glycyrrhiza, herba lophatheri, herba artemisiae scopariae, codonopsis pilosula, fructus gardeniae, rheum officinale, semen coicis, caulis sargentodoxae, fructus mume, borneol, christina loosestrife herb, polyporus umbellatus, fructus galangae, radix curcumae longae, rhizoma acori graminei, fructus lycii, rhizoma belamcandae, radix paeoniae rubra and radix trichosanthis. The traditional Chinese medicine composition provided by the invention can be separately utilized or matched up with radiotherapy and chemotherapy, and have the effects of reducing the lumps in a short period and effectively controlling the metastatic spread of cancer cells; and moreover, the traditional Chinese medicine composition is capable of strengthening the immunologic function of the organisms so as to achieve the aims of inhibiting the growth of the cancer cells, being free of side effects simultaneously, enhancing the immunity of the organisms while treating and resisting the cancers, alleviating the pain of the patients, stabilizing the state of the illness, prolonging the life cycle and increasing the proportion of clinically treating the patients.

Description

A kind of Chinese medicine composition of treating cancer of pancreas and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, relate in particular to a kind of Chinese medicine composition that is used to treat cancer of pancreas and preparation method thereof.

Background technology

Cancer of pancreas is more rare in malignant tumor of digestive tract, is more common in 40～60 years old, and the man is more than the woman, and cancer of pancreas mostly occurs in head of pancreas portion, and only minority occurs in body of pancreas and tail of pancreas portion.Cancer of pancreas is because the morning and evening of the position that cancerous protuberance takes place and the course of disease is different, and clinical symptoms is different.The symptom of stomachache for occurring the earliest is more common in body of pancreas and tail of pancreas portion, big multidirectional lower back radiation.The state of an illness can have jaundice in evolution, abdominal mass can appear in late period, heating, and supraclavicular lymph nodes is modal metastasis site.Modern medicine thinks that primary disease maybe be relevant with chronic pancreatic diseases with carcinogen in the environment, coffee, smoking.Cancer of pancreas is a kind of comparatively dangerous malignant tumor, though China nearly 1 people of per 20,000 philtrums suffers from cancer of pancreas, and should the fast-growth case fatality rate height of disease.NIH's report, 1 year survival rate of cancer of pancreas is 8%, 5 year survival rate 3%.5 years survival rates of China's Statistical data only about 5%.Sickness rate significantly rises year by year in recent years, has raise 3 times in the period of U.S.'s cancer of pancreas sickness rate 10, neopathy 43140 examples in 2010, and dead 36800 examples occupy malignant tumor and fall ill the tenth, and mortality rate but is in the 4th.China's cancer of pancreas morbidity and death toll ascendant trend be highly significant especially, and nearly 20 annual morbidities increase about 6 times.According to 38 registry, whole nation tumor registration data in 2007, the cancer of pancreas morbidity occupies the 7th of malignant tumor, and case fatality rate occupies the 6th of malignant tumor.

The total pathogenesis of cancer of pancreas is that weakness of the spleen and stomach, depression of liver-QI cause the stagnation of QI, blood stasis, damp and hot for suffering from, and forms hard piece for a long time.Carcinoma of head of pancreas with damp and hot show as many, the then cards of seeing the insufficiency of the spleen stagnation of QI of body of pancreas, carcinoma of tail of pancreas more.The treatment in cancer of pancreas late period should or be attacked or mend or reinforcement and elimination in combination according to the disease different phase.

Cancer of pancreas is main with operative treatment in early days, and the suitable chemotherapy of postoperative in conjunction with long-term Chinese medicine, might obtain good efficacy; Mid-term, many operations palliative treatments can not be excised like operation, and feasible cholecystojejunostomy to be to alleviate jaundice, Chinese medicine simultaneously, but also combined with radiotherapy, chemotherapy etc.; Be main with Chinese medicine and symptomatic treatment late period then, or combine low dose of chemotherapy.The method of heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, regulating qi-flowing for strengthening spleen is adopted in cancer of pancreas Chinese traditional treatment in late period more.

Cancer of pancreas belongs to categories such as the traditional Chinese medical science " fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times ", " mass in the abdomen ", " jaundice ", " gathering ", and its cause of disease, pathogenesis are mainly internal injury caused by excess of seven emotions, eating and drinking without temperance and cause that the liver spleen is impaired, internal organs are become estranged, turbid damp blocks, qi depression to blood stasis, with the passing of time form primary disease; Also early have recognized that the relation of primary disease and diet delicious food and jaundice at " interior warp "; Say like " element is asked the logical deficiency and excess opinion of commenting ": " fullness caused by stagnant QI is sent out contrary for diseases due to endogenous heat of ZANG FU organs sudden falling down, hemiplegia flaccidity with cold limbs; sweet fertile high official, and then the disease of Sorghum vulgare Pers. also ".The traditional Chinese medical science thinks that primary disease is many by depression of liver-QI, and is then insufficiency of the spleen for a long time due to the functional activity of QI being not smooth, insufficiency of the spleen resulting in production of dampness, and strongly fragrant and heat-transformation, with the passing of time delay then causes qi depression to blood stasis, knot in the pyretic toxicity.So the methods such as depressed liver-energy dispersing and function of gallbladder promoting, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, removing mass eliminating stagnation that adopt are gone up in treatment more.

The cancer of pancreas early symptom also is not true to type, and often shows as the symptom that is similar to other organ diseases, causes some Symptomatic by sing misdiagnosis and mistreatment; Great majority are diagnosed as the cancer of pancreas, and the person has been metastasis is arranged or to the advanced pancreatic cancer of metastasis sign, but doctor trained in Western medicine can only be operation, radiotherapy, chemotherapy to cancer of pancreas treatment of late stage poor effect; Cut again and cut; Finish up to life, patient spends in misery always, has only less than 20% patient to exist radical operation to hope.Symptoms such as weight loss, stomachache, jaundice, appetite difference can appear in most of Pancreas cancer patients; Epigastric discomfort, abdominal distention, weak symptom can take place in half left and right sides patient; About twenty percent patient has lumbago and backache, diarrhoea, melena, and losing weight is the symptom that Pancreas cancer patients is seen at most.The early stage patient cardinal symptom is poor, the abdominal distention, weak of epigastric discomfort, appetite, in case weight loss, stomachache, jaundice take place then point out to be middle and advanced stage.The traditional Chinese medical science claims that pancreas is that spleen is long-pending, and pancreas jaundice, stomachache are all caused by insufficiency of the spleen.At present, clinical many single method treatment advanced pancreatic cancer that do not adopt adopt the Chinese medicine integrated approach more, to control the evolution of tumor to greatest extent, alleviate less patient suffering, improve patient's quality of life, prolong patient's life.

Summary of the invention

Technical problem to be solved by this invention is; Utilize the traditional theory of Chinese medical science of China, provide that a kind of side effect is little, good effect, cost are low, have no drug resistance, alleviate less patient suffering, improve patient quality of life, prolong the Chinese medicine composition and preparation method thereof of the treatment cancer of pancreas of patient's life.

For solving the problems of the technologies described above; The invention provides a kind of Chinese medicine composition of treating cancer of pancreas, its raw medicinal material comprises: Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Violae, Herba Patriniae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Herba Artemisiae Scopariae, Radix Codonopsis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Borneolum Syntheticum, Herba Lysimachiae, Polyporus, Fructus Galangae, Rhizoma Curcumae Longae, Rhizoma Acori Graminei, Fructus Lycii, Rhizoma Belamcandae, Radix Paeoniae Rubra and Radix Trichosanthis.

The ratio of weight and number of the raw medicinal material in the said Chinese medicine composition is: Herba Sarcandrae 20～35 weight portions; Zaocys 8～15 weight portions; Herba Scutellariae Barbatae 12～15 weight portions; Herba Lobeliae Chinensis 15～30 weight portions; Herba Hedyotidis Diffusae 20～30 weight portions; Herba Taraxaci 30～50 weight portions; Herba Violae 25～40 weight portions; Herba Patriniae 18～30 weight portions; Flos Lonicerae 35～50 weight portions; Fructus Forsythiae 10～20 weight portions; Radix Glycyrrhizae 20～35 weight portions; Herba Lophatheri 20～30 weight portions; Herba Artemisiae Scopariae 15～25 weight portions; Radix Codonopsis 16～34 weight portions; Fructus Gardeniae 15～20 weight portions; Radix Et Rhizoma Rhei 10～15 weight portions; Semen Coicis 20～40 weight portions; Caulis Sargentodoxae 15～30 weight portions; Fructus Mume 20～35 weight portions; Borneolum Syntheticum 25～30 weight portions; Herba Lysimachiae 15～25 weight portions; Polyporus 20～35 weight portions; Fructus Galangae 20～45 weight portions; Rhizoma Curcumae Longae 15～20 weight portions; Rhizoma Acori Graminei 10～15 weight portions; Fructus Lycii 25～35 weight portions; Rhizoma Belamcandae 18～25 weight portions; Radix Paeoniae Rubra 15～25 weight portions and Radix Trichosanthis 30～50 weight portions.

The ratio of weight and number of the raw medicinal material in the said Chinese medicine composition also can further be preferably: Herba Sarcandrae 25～30 weight portions; Zaocys 10～15 weight portions; Herba Scutellariae Barbatae 12～15 weight portions; Herba Lobeliae Chinensis 15～20 weight portions; Herba Hedyotidis Diffusae 20～25 weight portions; Herba Taraxaci 30～40 weight portions; Herba Violae 30～35 weight portions; Herba Patriniae 20～25 weight portions; Flos Lonicerae 35～45 weight portions; Fructus Forsythiae 15～20 weight portions; Radix Glycyrrhizae 20～30 weight portions; Herba Lophatheri 20～25 weight portions; Herba Artemisiae Scopariae 15～20 weight portions; Radix Codonopsis 20～30 weight portions; Fructus Gardeniae 15～20 weight portions; Radix Et Rhizoma Rhei 10～15 weight portions; Semen Coicis 20～30 weight portions; Caulis Sargentodoxae 15～25 weight portions; Fructus Mume 20～30 weight portions; Borneolum Syntheticum 28～30 weight portions; Herba Lysimachiae 20～25 weight portions; Polyporus 30～35 weight portions; Fructus Galangae 30～40 weight portions; Rhizoma Curcumae Longae 15～28 weight portions; Rhizoma Acori Graminei 10～12 weight portions; Fructus Lycii 30～35 weight portions; Rhizoma Belamcandae 20～25 weight portions; Radix Paeoniae Rubra 20～25 weight portions and Radix Trichosanthis 30～40 weight portions.

The ratio of weight and number of the raw medicinal material in the said Chinese medicine composition can further be preferably again: Herba Sarcandrae 28 weight portions; Zaocys 12 weight portions; Herba Scutellariae Barbatae 15 weight portions; Herba Lobeliae Chinensis 15 weight portions; Herba Hedyotidis Diffusae 22 weight portions; Herba Taraxaci 35 weight portions; Herba Violae 32 weight portions; Herba Patriniae 23 weight portions; Flos Lonicerae 40 weight portions; Fructus Forsythiae 18 weight portions; Radix Glycyrrhizae 25 weight portions; Herba Lophatheri 20 weight portions; Herba Artemisiae Scopariae 15 weight portions; Radix Codonopsis 26 weight portions; Fructus Gardeniae 15 weight portions; Radix Et Rhizoma Rhei 15 weight portions; Semen Coicis 25 weight portions; Caulis Sargentodoxae 20 weight portions; Fructus Mume 30 weight portions; Borneolum Syntheticum 30 weight portions; Herba Lysimachiae 20 weight portions; Polyporus 30 weight portions; Fructus Galangae 35 weight portions; Rhizoma Curcumae Longae 20 weight portions; Rhizoma Acori Graminei 10 weight portions; Fructus Lycii 35 weight portions; Rhizoma Belamcandae 25 weight portions; Radix Paeoniae Rubra 20 weight portions and Radix Trichosanthis 35 weight portions.

The raw medicinal material of said Chinese medicine composition can further include Poria 15～20 weight portions, Radix Ginseng 25～35 weight portions and the Rhizoma Atractylodis Macrocephalae 20～30 weight portions; Be preferably: Poria 18 weight portions, Radix Ginseng 30 weight portions and the Rhizoma Atractylodis Macrocephalae 25 weight portions.

The present invention also provides a kind of method for preparing of above-mentioned Chinese medicine composition, and the dosage form of said Chinese medicine composition is for containing tablet, and it may further comprise the steps,

The first step by said mixed, is used the dissolve with ethanol with respect to 4～6 times determining alcohol 90%～95% of the mixture quality that obtains with Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei and Radix Trichosanthis; Reflux was extracted after 2～4 hours, filtered, and filtering residue is used the dissolve with ethanol with respect to 2～4 times determining alcohol 85%～95% of the mixture quality that obtains once more; Reflux was extracted after 1～2 hour once more; Filter, merge filtrating twice, decompression recycling ethanol and to be concentrated into liquor strength be 0.8～1.2g crude drug/mL; Above-mentioned filtrating is the macroporous adsorptive resins of 5L through volume; With the deionized water or the distilled water eluting of 5 times of resin column volumes, the determining alcohol of 3 times of resin column volumes of reuse is 90%～95% ethanol elution earlier, collects ethanol elution; Concentrating under reduced pressure is removed ethanol, and drying also is ground into powder;

Second step; Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are pressed said mixed; The alcohol heating reflux that adds with respect to 3～5 times determining alcohol 85%～95% of the mixture quality that obtains extracts 2 times; Extracted twice liquid merges; With the centrifugal remove impurity of tube centrifuge, relative density was 1.20～1.23 mastic when the extracting solution after the remove impurity was evaporated to 60 ℃ under 60 ℃～70 ℃ condition, and the mastic after concentrating is dried to powder with spray dryer;

In the 3rd step, the surplus stock medical material by said mixed, is added 2～5 times water dissolution with respect to the mixture quality that obtains; Heating decocted 2～4 hours, filtered, and filtering residue is used 1～3 times water dissolution with respect to the mixture quality that obtains once more; Heating decocted 1～2 hour once more, filtered, and merged filtrate; Concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

In the 4th step,, further add with respect to the carboxymethyl starch sodium of 0.05～0.1 times of the mixture quality that obtains, 0.05～0.1 times microcrystalline Cellulose with three kinds of powder mixes that the front obtains; Mixing is granulated, after the drying; Granulate; Adding is with respect to the magnesium stearate of 0.01～0.05 times of the mixture quality that obtains, and is with decompressor that the granule compacting is in blocks then, promptly gets to contain tablet.

The present invention provides a kind of method for preparing of above-mentioned Chinese medicine composition again, and the dosage form of said Chinese medicine composition is a syrup, and it may further comprise the steps,

The first step by said mixed, is used the dissolve with ethanol with respect to 3～5 times determining alcohol 85%～95% of the mixture quality that obtains with Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei and Radix Trichosanthis; Reflux was extracted after 2～4 hours, filtered, and filtering residue is used the dissolve with ethanol with respect to 1～2 times determining alcohol 85%～95% of the mixture quality that obtains once more; Reflux was extracted after 1～2 hour once more; Filter, merge filtrate, decompression recycling ethanol and to be concentrated into liquor strength be 0.8～1.2g crude drug/mL; Above-mentioned filtrating is the macroporous adsorptive resins of 5L through volume; With the deionized water or the distilled water eluting of 5 times of resin column volumes, the determining alcohol of 3 times of resin column volumes of reuse is 90%～95% ethanol elution earlier, collects ethanol elution; Concentrating under reduced pressure is removed ethanol, and drying also is ground into powder;

Second step; Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are pressed said mixed; The alcohol heating reflux that adds with respect to 2～4 times determining alcohol 85%～95% of the mixture quality that obtains extracts 1～2 time; Extracting solution merges; With the centrifugal remove impurity of tube centrifuge, relative density was 1.20～1.23 mastic when the extracting solution after the remove impurity was evaporated to 60 ℃ under 60 ℃～70 ℃ condition, and the mastic after concentrating is dried to powder with spray dryer;

In the 3rd step, the surplus stock medical material by said mixed, is added 2～4 times water dissolution with respect to the mixture quality that obtains; Heating decocted 2～4 hours, filtered, and filtering residue is used 1～2 times water dissolution with respect to the mixture quality that obtains once more; Heating decocted 1～2 hour once more, filtered, and merged filtrate; Concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

In the 4th step, three kinds of powder mixes with top acquisition add the water dissolution with respect to 1.5～2 times of mixture qualities, regulate pH value to 7.0 with 40% sodium hydroxide solution; Stir, cold preservation is 48 hours～72 hours under 4 ℃～8 ℃ conditions, filters, and filtrating adds the sucrose with respect to 0.2～0.4 times of the mixture quality that obtains; Stir and dissolving, regulate pH value to 7.0, it is an amount of to add water, stirs; Static 12～18 hours, filter fill; Sterilization obtains syrup, and the crude drug concentration in the said syrup is 1.2g/mL～1.5g/mL.

The present invention provides a kind of method for preparing of above-mentioned Chinese medicine composition again, and the dosage form of said Chinese medicine composition is a capsule, and it may further comprise the steps,

The first step with said raw medicinal material proportional mixing, is put into marmite and was fried 20 minutes～40 minutes, is ground into smalls with pulverizer, is screened into 100 orders～200 purpose powder;

In second step, the determining alcohol that adds 2～4 times of the powder qualities that obtain with respect to the first step is 70～80% ethanol, and reflux 1～3 hour is extracted 2～3 times; Merge extractive liquid, filters and obtains alcohol extract, the alcohol extract concentrating under reduced pressure, and being recycled to does not have the alcohol flavor; Filter the medicinal residues that obtain and add distilled water again, decocted 1～3 hour at every turn, decoct 2～3 times, filter respectively with respect to 4～8 times of filtering residue quality; Merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes further concentrating under reduced pressure; Remove and to desolvate, drying obtains and gets dry extract;

The 3rd step was broken into 200 orders～400 purpose powder with said dried cream powder, in the powder that obtains, added excipient, disintegrating agent mixing, dry, pulverizing, added fluidizer, in incapsulating at last, obtained capsule;

Said excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in said capsule is 10～50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in said capsule is 5～20%;

Described fluidizer is that magnesium stearate, differential silica gel or other have the pharmaceutic adjuvant of fluidizer effect, and its weight content in said capsule is 0.1～5%.

Beneficial effect of the present invention:

Chinese medicine composition provided by the invention can use separately, also can cooperate chemicotherapy to use; Utilize the traditional theory of Chinese medical science of China, clinical practice is in the treatment of cancer of pancreas, and its effect can be dwindled lump in a short time; Effectively control cancer cell shifts diffusion, and the anticancer growth does not have side effects again simultaneously; Control cancer anticancer in, enhancing human body immunity power, and the purpose that alleviates the patient suffering, stablizes the state of an illness, prolongs life cycle and increase clinical cure patient's ratio; And can prevent that remaining cancerous cell from staging a comeback, and reduces relapse and metastasis greatly.

The specific embodiment

The invention provides a kind of Chinese medicine composition of treating cancer of pancreas, its raw medicinal material comprises: Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Violae, Herba Patriniae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Herba Artemisiae Scopariae, Radix Codonopsis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Borneolum Syntheticum, Herba Lysimachiae, Polyporus, Fructus Galangae, Rhizoma Curcumae Longae, Rhizoma Acori Graminei, Fructus Lycii, Rhizoma Belamcandae, Radix Paeoniae Rubra and Radix Trichosanthis.

Herba Sarcandrae: be the dry herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Summer, Qiu Erji gather, and remove impurity, shine in.Another name: Herba Pileae Scriptae, Herba Pileae Scriptae, synthetism lotus, Vanda amesiana Reichb. F.Bitter in the mouth, suffering, property is flat.GUIXIN, Liver Channel.Clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.Be used for heat in blood and send out speckle dermexanthesis, rheumatic arthralgia, traumatic injury.Cure mainly pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor etc.

Zaocys: another name: Zaocys, black Serpentis, sword ridge Serpentis, reshahar Serpentis, yellowish glaucoma Serpentis, sword ridge Zaocys, southern Serpentis.Sweet in the mouth, property is flat.Return Liver Channel.Dispel the wind collateral dredging, relieving convulsion.Be used for rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.

Herba Scutellariae Barbatae: another name: and the head grass, Herba Scutellariae Darbatae, Herba Carpesii Cernui, Aleuritopteris argentea (Gmel.) Fee, purple connect careless demifacet flower, and head is careless partially, small size India skullcap, tiger stings red, aftergrass, Herba hyperici attenuati etc.Acrid in the mouth, hardship; Cold in nature.Return lung meridian, Liver Channel, kidney channel.Heat-clearing and toxic substances removing; The dissipating blood stasis hemostasis; Inducing diuresis to remove edema.Cure mainly the pyretic toxicity carbuncle, have sore throat, lung abscess, acute appendicitis, scrofula, venom, traumatic injury, haematemesis, epistaxis, stranguria with blood, edema, jaundice, ascites and cancer.

Herba Lobeliae Chinensis: have another name called anxious separate rope, half of flower, Herba Lobeliae Chinensis, the edible kernel of melon seeds is careless, snake is careless, Herba Hedyotidis Diffusae etc.Acrid in the mouth, property is flat; GUIXIN, lung, small intestine meridian.Heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Cure mainly: venom, carbuncle furuncle, tonsillitis, eczema, tinea pedis, traumatic injury, jaundice due to damp-heat, appendicitis, enteritis, nephritis, cirrhotic ascites and multiple cancer.

Herba Hedyotidis Diffusae: be Herba Hedyotidis Diffusae, tongue house steward, Herba Otteliae Alismoidis, sharp knife grass, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia again.Mildly bitter flavor, sweet, cold in nature.Go into stomach, large intestine, small intestine meridian, have heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen is used for dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom; The puckery pain of pyretic stranguria, edema, dysentery, enteritis; Jaundice due to damp-heat, cards such as cancerous protuberance often utilize the Herba Hedyotidis Diffusae anticancer, and it has certain radiation resistance.

Herba Taraxaci: contain multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in the Herba Taraxaci plant, effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting are arranged.Herba Taraxaci contains protein, fat, carbohydrate, trace element and vitamin etc. simultaneously, and abundant nutritive value is arranged, and is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Sweet in the mouth, little hardship, cold in nature.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Cure mainly upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis; Dysentery, hepatitis, gallbladder is assisted inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease; Carbuncle furuncle furuncle, pharyngitis is controlled acute mastitis, lymphadenitis, scrofula; The furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection etc.

Herba Violae: bitter in the mouth, suffering, cold in nature.GUIXIN, Liver Channel.Heat-clearing and toxic substances removing, the removing heat from blood detumescence.Be used for furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, venom etc. are controlled in external application.

Herba Patriniae: have another name called that Herba Patriniae, Patrinia scabiosaefolia Fisch, imperial bud Herba Patriniae, patrima villosa, pool lose, Herba Setariae Plicatae, Chinese cabbage, Herba Sonchi Oleracei, maiden spend etc.Acrid in the mouth, hardship are slightly cold.Return liver, stomach, large intestine channel.Heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.Cure mainly acute appendicitis, the lung abscess hyperpyrexia is coughed vomiting bloody pus, pyretic toxicity skin ulcer furuncle, and furuncle is swollen bitterly, breast abdomen pain, appendicitis, enteritis, dysentery, puerperal abdonimal pain, dysmenorrhea etc.

Flos Lonicerae: have another name called Radix Ophiopogonis, Flos Lonicerae, JINHUA, Flos Lonicerae, Flos Lonicerae, close Flos Lonicerae; Flos Lonicerae, two bud flowers, two precious flowers, golden rattan, Soviet Union's flower, little egret flower; Exert stone roller between exerting, hang sloping glue appearance, glue is all run (the Dong nationality's name), the hot horse of lamb weeding hoe (Bouyei's Praenomen), and my Ta Menggenqiqige (Meng ethnic group's name), throwing is pinched; The moon people's air defense, diligent wall, beautiful parent shines, and qin is sternly flat, kind right imitate (Yao nationality's name).Sweet in the mouth, cold in nature.Return lung, the heart, stomach warp.The heat-clearing and toxic substances removing eliminating carbuncle, the diffusing expelling pathogenic factors from the exterior of a surname, eliminating pathogenic heat from blood to cure dysentery.Be used for the carbuncle furuncle, affection due to external wind and heat, toxic-heat and blood stasis, dysentery pus and blood etc.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance reaches thoroughly and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, and like fever of the body, dermexanthesis, send out cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.

Fructus Forsythiae: bitter in the mouth, cold nature; Go into lung, the heart, small intestine meridian; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold; Epidemic febrile disease is from the beginning of, warm joining the army, the hyperpyrexia excessive thirst, and coma is sent out speckle, the puckery pain of pyretic stranguria; Laryngopharynx swelling and pain, macule, carbuncle pyogenic infections from tumour or sore, acute nephritis, jaundice; Cards such as intestinal twinge, Fructus Forsythiae is inhibited to various bacteria, and human body is had cooling effect, and tangible antiinflammatory action is arranged.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Heat-clearing and toxic substances removing is arranged, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating with in, relieving spasm to stop pain is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, and is weak; Can alleviate contracture property pain in the abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal; Can play the QI invigorating neutralization through adding Radix Glycyrrhizae, be in harmonious proportion the effect of each raw medicinal material, the Radix Glycyrrhizae Yiqi and vein recovery; Throb with fear according to one's conscience with shared being used for such as Radix Ginsengs; Through modern pharmacological research, the glycyrrhizic acid that Radix Glycyrrhizae contains can strengthen the Detoxication and the resistance of cell, has the antiulcer effect.

Herba Lophatheri: have another name called Rhizoma lophantheri, Gallus jabouillei rice, golden pheasant rice, Herba Lophatheri, Folium Bambosae.Sweet, light, cold.GUIXIN, stomach, small intestine meridian.Clearing away heat-fire, relieving restlessness is quenched the thirst, inducing diuresis for treating stranguria syndrome.Be used for the calentura excessive thirst, the puckery pain of oliguria with reddish urine, aphtha of the mouth and tongue.Cure mainly: in the heart disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness, apoplectic aphasia in silence, pain wind syndrome of head, spasmolytic throb with fear, the pestilence fan is vexed, kill small worm, the slow spleen of heat extraction; Pregnant woman's head revolves and falls down to the ground; Children's hangs sore throat, dysphoria with smothery sensation in frightened carbuncle sky.

Herba Artemisiae Scopariae: have another name called Herba Artemisiae Scopariae, because of dirt, horse elder generation, because of Herba Artemisiae Scopariae, capillary wormwood, floss Artemisia, spire Herba Artemisiae Annuae, An Lvcao, Herba Artemisiae Sieversianae, Folium Pini Chinese mugwort, Tian Naili (Hakka) etc.Bitter in the mouth, suffering, cold nature.Return spleen, stomach, liver, gallbladder meridian.Eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.Be used for the jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc.The pharmaceutical research Herba Artemisiae Scopariae has function of gallbladder promoting, and liver function protecting is analgesic, antiinflammatory, blood fat reducing, blood pressure lowering, effects such as coronary dilating; Herba Artemisiae Scopariae has significant hepatoprotective effect, and to first, hepatitis B, icterohepatitis has significant curative effect.Function of gallbladder promoting is arranged, promote bile secretion, the effect that cholic acid and bilirubin are discharged in the increase bile. can increase the heart CF; Microcirculation improvement, and blood pressure lowering is arranged, blood fat reducing; Anticoagulation, diuresis is analgesic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.

Radix Codonopsis: sweet in the mouth, property is flat.Return spleen, lung meridian.The spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.Be used for deficiency of both the splenic and pulmonary QI, the lack of appetite asthenia, the cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power ability spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry is then grown stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not grown greasyly partially, inspires clear sun, gas in the vibration, and do not have dry fraud just.Radix Codonopsis has the QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than the spleen reinforcing nourishing the stomach, transfers regulating the function of middle-JIAO, has the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve modulation on immune status, disease resistance enhancemen; Facilitating digestion absorbs, and improves metabolism, promotes the absorption of intestinal to nutrient substance; Radix Codonopsis has certain antitumor assosting effect, can suppress the growth of gross tumor volume and weight, and reduces and shift.

Fructus Gardeniae: having another name called Yellow Fructus Gardeniae, Fructus Gardeniae, white toad, Mu Dan, bright, ancient wine vessel, stand, peach, Fructus Gardeniae, yellow Ovum Gallus domesticus, the yellow son etc. of clearing the fields of weeds more, is the fruit of Maguireothamnus speciosus Fructus Gardeniae.At present; The fruit of Fructus Gardeniae is a Chinese medicine; Belong to the 1st batch of medicine-food two-purpose resource of Ministry of Public Health promulgation, have effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, be usually used in treating diseases such as icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Bitter in the mouth, cold in nature.GUIXIN, liver, lung, stomach, tri-jiao channel.The pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; The externally used detumescence pain relieving.It is vexed to be used for calentura, jaundice due to damp-heat, and the puckery pain of stranguria, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles etc.; External treatment bruise pain.

Radix Et Rhizoma Rhei: have another name called general, yellow good, fire ginseng, skin as, another name for Sichuan Province Radix Et Rhizoma Rhei, Radixet Rhizoma Rhei, cow tongue Radix Et Rhizoma Rhei, bright and beautiful stricture of vagina, give birth to army, Radix Et Rhizoma Rhei.Hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.Heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dampness removing jaundice eliminating.Be used for the stagnant constipation of excess-heat, heat in blood is told nosebleed, the conjunctival congestion pharyngeal swelling, and carbuncle is treated skin ulcer, abdominalgia with intestinal abscess, blood stasis amenorrhea, postpartum stagnation, traumatic injury, hygropyretic dysentery, jaundice dark coloured urine, stranguria, edema; Externally treating burns and scalds.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Be used for the conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay eliminating fire and detoxication.Be used for pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.Be used for heat in blood stasis of blood hemorrhage is arranged.Modern medicine also prove Radix Et Rhizoma Rhei also have invigorate blood circulation, hemostasis, antibacterial, eliminate endotoxin, human body immunity improving power, reduce effects such as body temperature, analgesia.Radix Et Rhizoma Rhei contains anthraquinone, anthraquinone derivatives is stronger to staphylococcus, streptococcus antibacterial action; Tannin contained in the Radix Et Rhizoma Rhei has good astriction to wound surface, can promote the wound face healing.

Semen Coicis: have another name called Semen Coicis, Semen Coicis, Semen Coicis, native corn, Semen Coicis, a reality, heart of a lotus seed pearl, careless pearl pearl, jobstears, Semen Coicis, NLIUGU.Be the Chinese medicine of using always; Be again generally, the food often eaten also is a kind of beauty food; Normal food can keep human body skin gloss fine and smooth, eliminates acne, speckle passeris montani saturati, senile plaque, cyasma, butterfly spot, to desquamation, acne, chap, pachylosis etc. all has good efficacy.Sweet in the mouth, light, cool in nature.Return spleen, stomach, lung meridian.Diuretic infiltration is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, arrange dense, detoxicating and resolving stagnation of pathogens.Be used for edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, intestinal carbuncle; Wart, cancerous protuberance.1, to cardiovascular influence: suppress respiratory center, make particularly lung vasodilation of peripheral vessel.2, antitumor: it is more suitable to hold wet pulmonary carcinoma under the arm with the digestive tract tumor of insufficiency of the spleen leading to overabundance of dampness and expectorant heat especially.In recent years, a large amount of scientific research and clinical practices prove that Semen Coicis still is a kind of cancer therapy drug, Preliminary Identification, and it can reach more than 35% the suppression ratio of cancer.3, enhancing immunity and antiinflammatory action, the immunity of Semen Coicis oil pair cell, humoral immunization have facilitation.4, blood sugar lowering: can play the effect of blood vessel dilating and blood sugar lowering, especially hypertension, hyperglycemia had special efficacy.5, suppress the contraction of skeletal muscle: Semen Coicis can suppress Skeletal Muscle Contraction, can reduce the contracture of muscle, shortens its fatigue curve; Can suppress the contraction of striped muscle.6, calmness, analgesia and refrigeration function: have calmness, analgesia and refrigeration function.The rheumatic arthralgia patient there is good effect.7, fall blood calcium, slow down aging, improve the immunocompetence of body.8, edema; Foot gas; Dribbling urination; Damp-warm diseases; The leukorrhagia of having loose bowels; Rheumatic arthralgia; The contracture of muscle arteries and veins; Lung abscess; The intestinal carbuncle; Verruca plana.

Caulis Sargentodoxae: have another name called that Caulis seu Radix Schisandrae Henryi, Caulis Sargentodoxae, DAHUOXUE, big blood are logical, Folium Styracis Suberifoliae rattan, Spatholobus sinensis chum et T. Chen., Chrysanthemum are fickle in love, mountain Caulis Sargentodoxae, Schisandra glaucescens Diels., Herba pteridii latiusculi heart rattan, yellow stalk rattan, five spend seven, Rhizoma Homalomenae etc.Bitter in the mouth, property is flat.Go into stomach, large intestine channel.Heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, the dissipating blood stasis that relieves internal heat, wind dispelling insecticide.Be used for abdominalgia with intestinal abscess, traumatic injury, dysmenorrhea, Fengshi Guanjie pain." Zhejiang traditional herbal medicine ": " property is flat, sour-puckery flavor." " Sichuan Chinese medicinal herbal ": " is cool in nature, and bitter in the mouth is nontoxic.″。Go into liver.Large intestine two warps." " Bencao Tujing ": " attacked blood, controls clot." " simple and easy medical herbs ": " controlled bones and muscles pain, chases after wind, strong waist knee joint, tonifying YANG thing." " Chinese medicinal herbal ": " the meridian dredging that dispels the wind, the diuresis parasite killing.Control acute appendicitis, rheumatic arthralgia, leprosy, gonorrhea: ascarid stomachache." " Hunan medicine will ": " is stimulated the menstrual flow and is enriched blood, bone and muscle strengthening, anthelmintic.Control traumatic injury, rheumatalgia, bruise, stranguria with blood, bones and muscles pain, furuncle, filaricide." " east, Fujian book on Chinese herbal medicine " " controlled trusted subordinate's angor, dysentery." Guangzhou army " Chinese herbal medicine handbook commonly used: " controls podomere aches, numbness contracture, and edema, blood deficiency is dizzy." " Shaanxi Chinese herbal medicine ": " anti-inflammation, dispersing swelling and dissipating binds, vital energy regualting and blood circulation-promoting, wind dispelling insecticide.Appendicitis curing, menoxenia, metrorrhagia, infantile malnutrition, ascarid, pinworm disease." " Zhiwu Mingshi Tukao ": Caulis Sargentodoxae, Mount Lushan, modern Jiangxi has it more.Overgrow, purple stem, a SANYE just like a leaf thumb branch, or half of circle, or has the angle and the side is amorphous, and is smooth thick tough.Root long number chi, outer purple words spoken by an actor from offstage.Radial striations is arranged, excavate and expose to the sun it, purple liquid Jin Run.Infusing drugs in wine one night, bright red such as blood.

Fructus Mume: have another name called dark plum, yellow young, close Chinese prunus mume (sieb.) sieb.et zucc., do a branch prunus mume (sieb.) sieb.et zucc., Fructus Mume, smoked prunus mume (sieb.) sieb.et zucc., Fructus Citri tangerinae plum pulp, prunus mume (sieb.) sieb.et zucc., spring prunus mume (sieb.) sieb.et zucc. etc.Sour in the mouth, puckery, property is flat.Return liver, spleen, lung, large intestine channel.Astringe the lung, astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.Be used for chronic cough of deficiency lung, the chronic diarrhea chronic dysentery, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache; Chronic malaria; Have blood in stool; Hematuria; Metrorrhagia; Ancylostomiasis etc.

Borneolum Syntheticum: having another name called sheet brain, Fructus Citri tangerinae sheet, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., is that the resin and the volatile oil processed goods of Dipterocarpaceae plant Borneolum Syntheticum extracts the crystallization that obtains, and is near pure dextro Borneolum Syntheticum.Also useful chemical method is synthetic.Acrid in the mouth, hardship, cold nature.GUIXIN, spleen, lung meridian.The refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be used for calentura coma, convulsions, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, obstruction of qi in the chest and cardialgia, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.

Herba Lysimachiae: have another name called Lysimachia christinae Hance, Herba pteridis vittatae, copper coin grass, Herba cassiae torae, Herba Lysimachiae, Lysimachia christinae Hance, a string money, Herba Dichodrae, money false aloe, rattan rattan Herba Houttuyniae, big Herba Glechomae, LUBIANHUANG etc.Sweet in the mouth, one-tenth, cold nature.Return liver, gallbladder, kidney, urinary bladder channel.The wet jaundice eliminating of thorn, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling.Be used for jaundice due to damp-heat, gallbladder-distention hypochondriac pain, stranguria caused by urinary stone, pyretic stranguria, difficulty and pain in micturition, carbuncle furuncle, snake bite and insect sting.Modern study, these article mainly contain phenolic constituent and sterol, flavonoid, aminoacid, tannin, volatile oil, choline, potassium salt etc.Also have calculus, antibacterial, antiinflammatory action all has inhibitory action to humoral immunization, cellular immunization.

Grifola umbellata: Aphyllophorales Polyporaceae Ramalina medicinal fungi.Aka ground black peach, Poria pig, pig fungus, Jia vector pig, hog sack, Feng Ling, pink Polyporus Zhu Ling, wild boar feces, wild boar and other food.Sweet in the mouth, light, property is flat, returns kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen, detumescence.Control dysuria, edema, have loose bowels stranguria with turbid discharge, leukorrhagia etc.Polyporus contains polyporusum bellatus, and polyporusum bellatus can significantly strengthen mouse T cell to the breeder reaction to LPS of the breeder reaction of ConA and B cell.Polyporusum bellatus has tangible mitogenesis effect to the full splenocyte of mice.Under 12.5mg/ (kg days) dosage, polyporusum bellatus can obviously strengthen the specific antibody secretory cell number of mice to SRBC; Can obviously strengthen mice to special-shaped splenocyte delayed hypersensitivity and promote special-shaped splenocyte active cell poison T cell (CTL) killing and wounding to target cell.CTL is the important effect cell that immunity of organism is kept watch on, and in tumour immunity, has pivotal role.The antitumor action of polyporus extract: polyporus extract (being mainly polyporusum bellatus) has than significant inhibitory effect mice transplanted tumor S-180.Inhibitory rate 50-70%, the heavy suppression ratio of tumor reaches more than 30%.In the tumor-bearing mice of extract for treating, there is the 6-7% tumor to disappear fully approximately.Mice to tumor disappears fully inoculates tumor cell at 1-6 after the month, the tumor of all not growing; Extract is through administrations such as lumbar injection, intravenous injection and filling stomaches; Under doses, all can suppress growth of tumor, but the effect of filling stomach is poor than lumbar injection and intravenous injection, dosage is also big.The prevention administration plays tumor-inhibiting action to S-180.Do not showing under the dosage of antitumous effect with chemotherapeutic single, adding with an amount of polyporus extract and have remarkable antitumor action.To tumor-bearing mice spleen antibody produced cell showed increased, showing has significant enhancing antibody formation effect, can also significantly improve the tumor-bearing mice peritoneal macrophage and engulf vigor.These article can improve the content of cAMP in the S-180 ascites cells, and at the high experimental group of cancer cell multiplication suppression ratio, cAMP content lifting rate is also high in the cancerous cell, and cAMP content is lower than normal cell in the general cancerous cell, and it is low more that canceration worsens cAMP content more.CAMP can make tumor cell transform to normal cell.Polyporus ketone A-G, 7 kinds of chemical compounds have cytotoxicity to the L1210 cell, and the inhibitory action of dose dependent is arranged.Inhibitory action to experimental tumor of bladder: female rats awards carcinogen BBN [N-butyl-N-(4-hydroxyl butyl) nitrosamine] solution 0.25ml (90mg) and irritates stomach; 2 times weekly; In totally 12 weeks, every accumulated dose BBN is 2.16g, raises at the same time with Polyporus dry powder 90g/kg and feeds.The back execution of 30 weeks.The result shows; Bladder is always sent out ratio of outflow and is reduced to 61.1% by 100% of pathology matched group; Reduced 38.9%, every Mus number of tumors and tumor diameter significantly are lower than the pathology matched group, send out the cancer rate and reduce to 11.1% by 77.8% of pathology matched group; Reduced 66.7% and shown Polyporus, and do not had an obvious toxic-side effects the having of BBN bladder tumor than significant inhibitory effect.

Fructus Galangae: have another name called Semen Phaseoli, FRUCTUS GALANGAE, red button etc.Acrid in the mouth, warm in nature.Return spleen, lung meridian.Warming middle-JIAO dampness; Cold expelling dampness, being amusing helps digestion.Be used for coldness and pain in the epigastrium, the food stagnation distension, vomiting is had loose bowels, and drinks too much.Pharmacological action: 1. the seed decoct has excitation to the guinea pig in vitro intestinal tube.1-acetoxychavicol acetate 5,10g/kg lumbar injection, the gastric ulcer that rat ligation pylorus is caused has inhibitory action.1-acetoxychavicol acetate and 1-acetoxyeugenol acetate have the effect of tangible anti-ShayShi rat gastric ulcer, and when difference lumbar injection 2-Smg/kg and 5-10mg/kg, suppression ratio is 20-77% and 36-100%.2. antifungal and cytotoxic effect: the Galahal A (1) that these article contain, Galanal B (2), Galanolactone (3), (E)-8 (17); 12-Labddiene-15; 16-dial (4) and (E)-8B (17)-Epoxylabd-12-ene-15,16-dial (5) has antifungal and cytotoxic effect.3. active anticancer: from the methanolic extract of fruit, get multiple chemical compound; To wherein 1-acetoxy-chavicol ethyl ester and 1-acetoxyl group Eugenol acetate again; Give the dosage of mice by intraperitoneal injection 10mg/kg, continuous 5 days, find to have very strong active anticancer.The latter's toxicity is lower than the former.Compare with other synthetic ingredient, the 1-acetoxyl group is very important to active anticancer, estimates that its mechanism of action is relevant with nucleophillic attack.

Rhizoma Curcumae Longae: have another name called HUANGJIANG, hair Rhizoma Curcumae Longae, tripod perfume, Huang Siyu etc.Acrid in the mouth, hardship, warm in nature.Return spleen, Liver Channel.The removing blood stasis circulation of qi promoting, the dysmenorrhea pain relieving.Be used for the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, dysmenorrhea amenorrhea ， mass in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.Modern pharmacological research, mainly the acting as of Rhizoma Curcumae Longae: 1. effect for reducing blood fat; 2. antitumor action; 3. antiinflammatory action; 4. resisting pathogenic microbes effect; 5. to the influence of cardiovascular system; 6. choleretic effect; 7. to the effect of termination of pregnancy; 8. antioxidation; 9. photo effect effect; 10. other effect: curcumin can suppress the biosynthesis of PGS.Rhizoma Curcumae Longae also can kill fly.Chloroform of Rhizoma Curcumae Longae and ether extract are external to have inhibitory action to Trichophyton and microsporon gypseum.Turmeronol A and B can suppress the Semen sojae atricolor LOX, and its IC50 is respectively 16 and 19 μ mol/L.These two kinds of chemical compounds can prevent linoleic autoxidation when-200ppm concentration.

Rhizoma Acori Graminei: have another name called prosperous, Chinese onion when Rhizoma Acori Graminei, prosperous sun, prosperous grass, Yao, Yao's fragrant-flowered garlic, haze tallow, spring snow, see disappear, water Rhizoma Acori Graminei, bitter Rhizoma Acori Graminei, powder Chang, Rhizoma Acori Graminei, sword-like leave, Rhizoma Acori Graminei, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek, Herba Kyllingae, Rhizoma et radix valerianae etc.Acrid in the mouth, hardship, warm in nature.GUIXIN, stomach warp.The eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae, removing dampness appetizing.Be used for the coma epilepsy, forgetful insomnia, Hiccough and deaf, the gastral cavity painful abdominal mass is not hungry, mouthful dysentery of keeping silent; Regulate the flow of vital energy, invigorate blood circulation, the wind that looses dries.Control epilepsy, syncope due to accumulation of phlegm, the calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, diseases such as traumatic injury.

Fructus Lycii: have another name called Fructus Lycii, Fructus Lycii red real, Radix Betae is sub, FRUCTUS LYCII BARBARI, Canis familiaris L. milk, dark purple green pepper, Chinese holly hoof etc.Sweet in the mouth, property are put down.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.Liver and kidney tonifying is arranged, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; Cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.

Shegan: also known as Wu Fan, Wu Po, Huang Yuan, Wu Sha, dry night, black wooden fan, black blowing grass ginger, ghost fan, phoenix wings and so on.Bitter in the mouth, cold in nature.Return lung meridian.Heat-clearing and toxic substances removing, expectorant, sore-throat relieving.Be used for pyretic toxicity phlegm-fire Tai knot, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.

Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for heat and go into nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, abdominal mass abdominal mass stomachache, injury from falling down, carbuncle skin infection.Giving birth to Radix Paeoniae Rubra wins with clearing away heat and cooling blood power.The fever of the body that is used for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases hemorrhage more, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.Wine Radix Paeoniae Rubra: win with promoting blood circulation to remove blood stasis power, a little less than the clearing away heat and cooling blood effect.Be used for amenorrhea or dysmenorrhea, traumatic injury more.The Radix Paeoniae Rubra branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.These article function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.

Radix Trichosanthis: sweet in the mouth, little hardship, cold nature.Attach to the lung and stomach meridians.Clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis.Be used for the calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst; Cards such as sore swollen toxin, Radix Trichosanthis has inhibition and stimulates dual function immune system, and cancerous cell is had efficient direct killing effect; " book on Chinese herbal medicine converge with speech ": Radix Trichosanthis, it is hot and suffocating to move back the five internal organs, contains and dry tongue and mouth like heart-fire; Lung-fire is contained and the pharyngeal swelling sore throat, and spleen-fire is contained and the dispute tooth is swollen, and phlegm-fire is contained and cough is not peaceful.The migratory arthralgia caused by wind if the side of body of liver-fire expands, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle burst and burst, and pyretic toxicity does not loose, or five types of jaundice yellow skin and eye, and if little water is due to all burning hot pent-up if drench puckery, only this agent ability relieving stagnation falls phlegm-fire, and can control it.Its property is sweet cold again, kindly can control yearningly, controls empty yearningly from tonic, and it is thirsty to control fire from the medicine of a cold nature, controls strongly fragrant yearningly from the gas medicine, controls excessive thirst from the blood medicine, is to control thirsty key medicine also.

The ratio of weight and number of the raw medicinal material in the said Chinese medicine composition can be preferably: Herba Sarcandrae 20～35 weight portions; Zaocys 8～15 weight portions; Herba Scutellariae Barbatae 12～15 weight portions; Herba Lobeliae Chinensis 15～30 weight portions; Herba Hedyotidis Diffusae 20～30 weight portions; Herba Taraxaci 30～50 weight portions; Herba Violae 25～40 weight portions; Herba Patriniae 18～30 weight portions; Flos Lonicerae 35～50 weight portions; Fructus Forsythiae 10～20 weight portions; Radix Glycyrrhizae 20～35 weight portions; Herba Lophatheri 20～30 weight portions; Herba Artemisiae Scopariae 15～25 weight portions; Radix Codonopsis 16～34 weight portions; Fructus Gardeniae 15～20 weight portions; Radix Et Rhizoma Rhei 10～15 weight portions; Semen Coicis 20～40 weight portions; Caulis Sargentodoxae 15～30 weight portions; Fructus Mume 20～35 weight portions; Borneolum Syntheticum 25～30 weight portions; Herba Lysimachiae 15～25 weight portions; Polyporus 20～35 weight portions; Fructus Galangae 20～45 weight portions; Rhizoma Curcumae Longae 15～20 weight portions; Rhizoma Acori Graminei 10～15 weight portions; Fructus Lycii 25～35 weight portions; Rhizoma Belamcandae 18～25 weight portions; Radix Paeoniae Rubra 15～25 weight portions and Radix Trichosanthis 30～50 weight portions.

Poria: also known as dodder Fu, Fu Ling, Fu Ling, Fu Ling, volts dodder, pine delicious, purple morning volt tire, Yun Ling, Fu Rabbit, pine potato, cassava, pine, pine Ling and so on.Sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.Modern medicine study: Poria ability enhancing human body immunity function, pachyman has tangible antitumor and protects the liver dirty effect.

Radix Ginseng: SHANSHEN, Park Ginseng, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), wooden club, Rhizoma Panacis Japonici, SHENCAO, HUANGSHEN, Herba Wedeliae Wallichii, Herba Stellariae Saxatilis, hundred chi pestles, extra large fat, the beautiful door screen of golden well, Radix Ginseng etc.Sweet in the mouth, little hardship, slightly warm in nature.Return spleen, lung, the heart, kidney channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid and nourishes blood, the Fructus Alpiniae Oxyphyllae of calming the nerves.Be used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, deficiency of qi and blood, prolonged illness is empty wins, the palpitation with fear insomnia, sexual impotence official is cold.Cure mainly: impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency be multiple, the disease of all qi-blood-body fluid deficiencies.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, cards such as frequent fetal movement; Effects such as the Rhizoma Atractylodis Macrocephalae has adjustment gastrointestinal motility function, antiulcer, protects the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction.The Rhizoma Atractylodis Macrocephalae also has effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor; The Rhizoma Atractylodis Macrocephalae can improve body's immunological function, leukocyte increasing quantity, the special active immunity of new-added item cancer cell antigen property antibody; Through reducing the rate of increase of oncocyte; Lower the aggressive of tumor tissue, improve body antitumor respond and, thereby suppress tumor the cytotoxic effect of oncocyte.The Rhizoma Atractylodis Macrocephalae has cytotoxic effect to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection also has remarkable inhibitory action to the murine sarcoma people.

When the dosage form of said Chinese medicine composition when containing tablet, its preparation method may further comprise the steps:

When the dosage form of said Chinese medicine composition was syrup, its preparation method may further comprise the steps:

When the dosage form of said Chinese medicine composition is a capsule, its preparation method may further comprise the steps:

Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.

Embodiment 1: the present invention preparation contain tablet

Herba Sarcandrae 28g; Zaocys 12g; Herba Scutellariae Barbatae 15g; Herba Lobeliae Chinensis 15g; Herba Hedyotidis Diffusae 22g; Herba Taraxaci 35g; Herba Violae 32g; Herba Patriniae 23g; Flos Lonicerae 40g; Fructus Forsythiae 18g; Radix Glycyrrhizae 25g; Herba Lophatheri 20g; Herba Artemisiae Scopariae 15g; Radix Codonopsis 26g; Fructus Gardeniae 15g; Radix Et Rhizoma Rhei 15g; Semen Coicis 25g; Caulis Sargentodoxae 20g; Fructus Mume 30g; Borneolum Syntheticum 30g; Herba Lysimachiae 20g; Polyporus 30g; Fructus Galangae 35g; Rhizoma Curcumae Longae 20g; Rhizoma Acori Graminei 10g; Fructus Lycii 35g; Rhizoma Belamcandae 25g; Radix Paeoniae Rubra 20g and Radix Trichosanthis 35g.

Its preparation method may further comprise the steps:

The first step by said mixed, is used the dissolve with ethanol with respect to 5 times determining alcohol 95% of the mixture quality that obtains with Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei and Radix Trichosanthis; Reflux was extracted after 3 hours, filtered, and filtering residue is used the dissolve with ethanol with respect to 3 times determining alcohol 90% of the mixture quality that obtains once more; Reflux was extracted after 2 hours once more, filtered, and merged filtrating twice; Decompression recycling ethanol and to be concentrated into liquor strength be 1.2g crude drug/mL, above-mentioned filtrating is the macroporous adsorptive resins of 5L through volume, earlier with the deionized water or the distilled water eluting of 5 times of resin column volumes; The determining alcohol of 3 times of resin column volumes of reuse is 90% ethanol elution; Collect ethanol elution, concentrating under reduced pressure is removed ethanol, and drying also is ground into powder;

Second step; Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are pressed said mixed; The alcohol heating reflux that adds with respect to 4 times determining alcohol 90% of the mixture quality that obtains extracts 2 times; Extracted twice liquid merges; With the centrifugal remove impurity of tube centrifuge, relative density was 1.20～1.23 mastic when the extracting solution after the remove impurity was evaporated to 60 ℃ under 60 ℃～70 ℃ condition, and the mastic after concentrating is dried to powder with spray dryer;

The 3rd step by said mixed, added 4 times water dissolution with respect to the mixture quality that obtains with the surplus stock medical material, and heating decocted 3 hours, filtered; Filtering residue is used 3 times water dissolution with respect to the mixture quality of acquisition once more, and heating decocted 2 hours once more, filtered, and merged filtrate, and concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

In the 4th step,, further add with respect to the carboxymethyl starch sodium of 0.08 times of the mixture quality that obtains, 0.08 times microcrystalline Cellulose with three kinds of powder mixes that the front obtains; Mixing is granulated, after the drying; Granulate; Adding with decompressor with the granule compacting in flakes, promptly gets the tablet that contains of present embodiment then with respect to the magnesium stearate of 0.03 times of the mixture quality that obtains.

The capsule of embodiment 2 the present invention preparation

Herba Sarcandrae 25g; Zaocys 10g; Herba Scutellariae Barbatae 13g; Herba Lobeliae Chinensis 18g; Herba Hedyotidis Diffusae 23g; Herba Taraxaci 40g; Herba Violae 35g; Herba Patriniae 20g; Flos Lonicerae 35g; Fructus Forsythiae 15g; Radix Glycyrrhizae 30g; Herba Lophatheri 22g; Herba Artemisiae Scopariae 18g; Radix Codonopsis 28g; Fructus Gardeniae 16g; Radix Et Rhizoma Rhei 12g; Semen Coicis 20g; Caulis Sargentodoxae 16g; Fructus Mume 25g; Borneolum Syntheticum 28g; Herba Lysimachiae 22g; Polyporus 32g; Fructus Galangae 30g; Rhizoma Curcumae Longae 25g; Rhizoma Acori Graminei 11g; Fructus Lycii 30g; Rhizoma Belamcandae 22g; Radix Paeoniae Rubra 23g; Radix Trichosanthis 32g; Poria 18g; Radix Ginseng 30g and Rhizoma Atractylodis Macrocephalae 25g.

Its preparation method may further comprise the steps:

The first step with said raw medicinal material proportional mixing, is put into marmite and was fried 35 minutes, is ground into smalls with pulverizer, is screened into 120 purpose powder;

In second step, the determining alcohol that adds 4 times of the powder qualities that obtain with respect to the first step is 80% ethanol, and reflux 3 hours is extracted 2 times; Merge extractive liquid, filters and obtains alcohol extract, the alcohol extract concentrating under reduced pressure, and being recycled to does not have the alcohol flavor; Filter the medicinal residues that obtain and add distilled water again, decocted 2 hours at every turn, decoct 2 times, filter respectively with respect to 6 times of filtering residue quality; Merging filtrate gets the water extract, water extract concentrating under reduced pressure, and the concentrated solution of the alcohol extract that obtains with the front mixes further concentrating under reduced pressure; Remove and to desolvate, drying obtains and gets dry extract;

The 3rd step was broken into 300 purpose powder with said dried cream powder, in the powder that obtains, added excipient, disintegrating agent mixing, dry, pulverizing, added fluidizer, in incapsulating at last, obtained capsule;

Wherein, excipient is starch and/or dextrin, and its weight content in capsule is 20%;

Disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in capsule is 10%;

Fluidizer is a magnesium stearate, and its weight content in capsule is 2%.

Embodiment 3 syrups of the present invention

Herba Sarcandrae 30g; Zaocys 14g; Herba Scutellariae Barbatae 12g; Herba Lobeliae Chinensis 16g; Herba Hedyotidis Diffusae 25g; Herba Taraxaci 30g; Herba Violae 30g; Herba Patriniae 23g; Flos Lonicerae 45g; Fructus Forsythiae 20g; Radix Glycyrrhizae 22g; Herba Lophatheri 24g; Herba Artemisiae Scopariae 15g; Radix Codonopsis 30g; Fructus Gardeniae 20g; Radix Et Rhizoma Rhei 10g; Semen Coicis 30g; Caulis Sargentodoxae 25g; Fructus Mume 30g; Borneolum Syntheticum 29g; Herba Lysimachiae 25g; Polyporus 33g; Fructus Galangae 40g; Rhizoma Curcumae Longae 26g; Rhizoma Acori Graminei 12g; Fructus Lycii gives 33g; Rhizoma Belamcandae 25g; Radix Paeoniae Rubra 25g; Radix Trichosanthis 40g.

Its preparation method may further comprise the steps:

The first step by said mixed, is used the dissolve with ethanol with respect to 4 times determining alcohol 90% of the mixture quality that obtains with Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Acori Graminei and Radix Trichosanthis; Reflux was extracted after 3 hours, filtered, and filtering residue is used the dissolve with ethanol with respect to 2 times determining alcohol 95% of the mixture quality that obtains once more; Reflux was extracted after 2 hours once more, filtered, and merged filtrate; Decompression recycling ethanol and to be concentrated into liquor strength be 1.0g crude drug/mL, above-mentioned filtrating is the macroporous adsorptive resins of 5L through volume, earlier with the deionized water or the distilled water eluting of 5 times of resin column volumes; The determining alcohol of 3 times of resin column volumes of reuse is 95% ethanol elution; Collect ethanol elution, concentrating under reduced pressure is removed ethanol, and drying also is ground into powder;

Second step; Rhizoma Belamcandae, Radix Paeoniae Rubra, Herba Violae, Herba Patriniae, Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Herba Lysimachiae and Polyporus are pressed said mixed; The alcohol heating reflux that adds with respect to 4 times determining alcohol 95% of the mixture quality that obtains extracts 2 times; Extracting solution merges; With the centrifugal remove impurity of tube centrifuge, relative density was 1.20～1.23 mastic when the extracting solution after the remove impurity was evaporated to 60 ℃ under 60 ℃～70 ℃ condition, and the mastic after concentrating is dried to powder with spray dryer;

In the 3rd step, the surplus stock medical material by said mixed, is added 3 times water dissolution with respect to the mixture quality that obtains; Heating decocted 2 hours, filtered, and filtering residue is used 2 times water dissolution with respect to the mixture quality that obtains once more; Heating decocted 2 hours once more, filtered, and merged filtrate; Concentrating under reduced pressure is removed moisture, and drying also is ground into powder;

In the 4th step, three kinds of powder mixes with top acquisition add the water dissolution with respect to 2 times of mixture qualities, regulate pH value to 7.0 with 40% sodium hydroxide solution, stir; Cold preservation is 48 hours under 5 ℃ of conditions, filters, and filtrating adds the sucrose with respect to 0.3 times of the mixture quality that obtains, and stirs and dissolving, regulates pH value to 7.0; It is an amount of to add water, stirs, and static 16 hours, filters; Fill, sterilization obtains syrup, and the crude drug concentration in the syrup is 1.2g/mL.

1. external used medicine toxicity test

Acute oral toxicity test: these article are by Ministry of Public Health " cosmetics health standard " (version in 2002) " test method(s) of once limiting the quantity of in the acute oral toxicity test ", and one time per os gives ICR mice, body weight 18g～22g; 20; The tablet that contains that the embodiment of the invention 1 obtains is used dissolved in distilled water, obtain to irritate stomach dosage 5000mg/kg body weight, irritate stomach amount 20ml/kg; Observed 15 days; Experimental animal is not found poisoning manifestations, is not had death, dissects after putting to death obviously unusually, judges that the article of being somebody's turn to do are to the nontoxic level in the true border of chmice acute per os toxicity.

The acute dermal toxicity test: these article are according to Ministry of Public Health " cosmetics health standard " (2002) second portion " acute dermal toxicity test " test method(s) of once limiting the quantity of, 20 of SD rats, male and female half and half; Body weight 90g～180g; The tablet that contains that the embodiment of the invention 1 obtains is pulverized, and adding 400g rubber, 400g Colophonium are processed coating, and one time percutaneous is smeared 5000mg/kg body weight dosage; Observed 15 days; Do not find obvious poisoning symptom, do not have death, animal gross anatomy no abnormality seen judges that the article of being somebody's turn to do are to the nontoxic level in the true border of rat acute percutaneous toxicity.

Acute skin irritation test: these article are according to 6.3 joints in Ministry of Public Health " cosmetics health standard " (2002) second portions " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg; According to the method for above-mentioned " acute dermal toxicity test ", preparation coating is got 0.5g then and is directly spread upon on the skin of animal left side (opposite side is as contrast); Adopt blocking test; 4 hours application time, after the off-test with the residual thing that tried of warm water washing, in remove tried thing after 1h, 24h, 48h and 72h observe respectively that animal is tried to distinguish and the dermoreaction of check plot; The top average is " 0 ", judges that the article of being somebody's turn to do are to the animal skin nonirritant.

2. endo-medicine long term toxicity test:

With the embodiment of the invention 1 contain tablet to mice by 7.81,18.34 and the 40.11g crude drug/12 weeks of kg continuous use (1.0ml/100g body weight; Every day 2 times) and after 4 week of drug withdrawal; The result shows: Chinese medicine preparation of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat; The internal organs naked eyes do not find that difference changes and the histological examination result shows; After 12 weeks of medication and 4 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Explain that toxicity is little after Chinese medicine preparation of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

3. tumor-inhibiting action test

Subjects: 100 of ICR mices, body weight 18-22g, male.

Test inoculation content: S ₁₈₀Solid tumor.

Get the ICR mice, in the subcutaneous conventional inoculation S of right axil ₁₈₀Cancerous cell suspension 0.2ml (about 5 * 10 ⁶Individual cell/ml), be divided into 4 groups next day at random.The treatment component is three groups, is respectively high dose group, middle dose groups and low dose group, adopts the tablet that contains of the embodiment of the invention 1, pulverizes the back dissolved in distilled water, and every day is gastric infusion 1.2ml, 0.8ml and 0.4ml respectively, continuous 10 days; Matched group is divided into two groups, is respectively normal saline group and CTX group, and normal saline group stomach every day is raised the 0.4ml normal saline, continuous 10 days; CTX group administration cyclophosphamide, administration every day 0.2g, gastric infusion behind the dissolved in distilled water, continuous 10 days; 4 groups are after the drug withdrawal and put to death animal next day, and the stripping tumor is weighed, and calculates tumour inhibiting rate, and the result shows that the present invention is to S ₁₈₀Growth has inhibitory action, and its tumour inhibiting rate increases with dosage and increases progressively, and has compared significant difference P＜0.05 with matched group.To S ₁₈₀Inhibitory action and tumor killing effect see table 1.

Table 1: to S ₁₈₀Inhibitory action and tumor killing effect

Group	Average tumor heavy (g)	The mice average weight changes (g)	Tumour inhibiting rate (%)
				High dose group	1.83±0.64	?+4.12	56.23
Middle dose groups	1.96±0.32	?+4.59	51.87
				Low dose group	2.18±0.57	?+4.92	48.32
The CTX group	1.64±0.28	?-1.62	61.36
				The normal saline group	3.22±0.96	?+4.97	0

Can know through table 1: adopt the treatment group of Chinese medicine preparation of the present invention, with the normal saline group relatively, can suppress the tumor bulk-growth, and tumour inhibiting rate increases progressively with the increase of dosage, significant difference P＜0.05 is arranged, (n=10, X ± SD); Adopt the treatment group of Chinese medicine preparation of the present invention, with the CTX group relatively, the body weight of the mice of treatment group has increase, and the mice of CTX group loses weight, both significant difference P＜0.05 of having compared, (n=10, X ± SD).

Measure through the fluid cell instrument in addition, the result shows that Chinese medicine preparation of the present invention has stoped tumor cell by S → G ₂Process has also influenced G simultaneously ₁The carrying out of → S makes S and G ₁The cell of phase obviously increases, G ₂Relatively low with the cell of M phase, disturbed the propagation activity of tumor cell, reach antineoplastic action.

4. clinical experiment

4.1 case is divided into groups and therapeutic scheme

With cancer of pancreas case 252 examples, wherein male 144 examples, women 108 examples, the age was adopted the random table method from 21 years old～72 years old, patient is divided into Chinese drug-treated group, chemotherapy group and Chinese medicine at random adds chemotherapy group;

Chinese drug-treated group 84 people, male 48 people, women 36 people, the oral embodiment of the invention 1 contain tablet, every day 3 times, each 2 is one-period around every.

Chemotherapy group 84 people, male 47 people, women 37 people, chemotherapeutics is selected cisplatin (CDDP) 30mg/M for use ²D1-3, the strong 1000mg/M that selects ²D1,8,15, fluorouracil (5-Fu) 500mg/M ²D1-5 selects wherein 2 kinds or 3 kinds of drug combinations during chemotherapy, intravenously administrable, and 28 days is one-period.

Chinese medicine adds chemotherapy group 84 people, male 49 people, and women 35 people, the capsule of the oral embodiment of the invention 2, every day 3 times, each 2, every is one-period all around; While intravenously administrable chemotherapeutics (the same chemotherapy group of method).

All confirm before all patient's radiotherapies through pathology; And all have the X line to take the photograph sheet, CT scan or nuclear magnetic resonance check to supply clinical TNM by stages; Inspection confirms no chemicotherapy contraindication before all doing chemotherapy by clinical criteria before the chemotherapy, and all patients do not have transfer cancer of pancreas (M0).

International cancer of pancreas TNM by stages with clinical stages:

International cancer of pancreas TNM is (UICC, 1987) by stages, and T refers to the primary tumo(u)r situation, and N refers to the lymph metastasis situation, and M refers to the metastasis situation.

(1) primary tumo(u)r (T) is by stages:

Tx: can not judge; T0: no primary tumo(u)r evidence; T1: former swelling do not exceed pancreas; T1a: tumor≤2cm; T1b: tumor＞2cm; T2: tumor invading duodenum, biliary tract or pancreas surrounding tissue; T3: tumor invading stomach, spleen, colon, trunk.

(2) zonule lymph node (N) is by stages:

Nx: can not judge; N0: regional lymph nodes does not have transfer; N1: regional lymph node metastasis is arranged;

(3) metastasis (M) is by stages:

Mx: can not judge; M0: no metastasis; M1: metastasis is arranged.

Clinical stages

The I phase: T1 N0 M0; T1 NX M0; TX N0 M0; TX NX M0.

The II phase: T2 N0 M0; T2 NX M0; T3 N0 M0; T3 NX M0.

The III phase: any T, N1, M0:.

The IV phase: any T, any N, M1.

4.2 evaluation criteria:, divide and alleviate (CR) fully: all visible at least 4 weeks of pathological changes complete obiteration according to WHO treatment malignant tumor evaluation criteria evaluation curative effect; Part is alleviated (PR): the tumor size estimation is dwindled >=50% 4 week at least; No change (NC): no at least 4 weeks of significant change, comprise that pathological changes is stable, the tumor size estimation enlarges less than 25%, dwindles less than 50%; Pathological changes expansion (PD): new focus occurs or original pathological changes is estimated to enlarge＞25%; 4 ranking pancreas portion's primary tumors and lymphatic metastasis kitchen range gross tumor volume change.

4.3 statistical method:

Meet rank test, paired t-test and independent sample t check with statistical package SPSS1010 Wileoxon.

4.4 result of the test

According to above-mentioned WHO evaluation criteria, drug treatment carried out the short term effect statistical effect after 4 months respectively, and the result sees table 2.

Table 2: each group short term effect tracking table record

Group	CR	PR	NC	PD	Effective percentage (%)
						Chinese drug-treated group	11	43	22	8	64.3
Chemotherapy group	6	27	35	16	39.3
						Chinese medicine adds chemotherapy group	15	46	18	5	72.6

Can know through table 2; Chinese medicine preparation of the present invention (general 3-6 month) in a short time obviously dwindles lump; Effectively control cancer cell diffusion; Increase clinical cure patient's ratio, and sum up and regular X line, CT or ultrasound diagnosis etc. through clinical observation, patient's patient's condition inquiry every day, confirm Chinese medicine preparation of the present invention in a short time (individual month of general 3-6) alleviate fast or eliminate epigastrium distension discomfort or distending pain, jaundice, tired, loss of appetite, become thin, symptoms such as diarrhoea or constipation; Alleviate the patient suffering, stablize the state of an illness; Can also increase simultaneously the therapeutic effect of chemotherapy, and reduce the side effect of chemotherapy.

All patients are carried out the long-term follow record, and when 1 year, 2 years, 3 years and 5 years, add up survival number and survival rate respectively, concrete data are seen table 3.

Table 3: each group long-term survival rate is followed the tracks of survival number and survival rate

Group	1 year	2 years	3 years	5 years
					Chinese drug-treated group	38(45.2)	31(36.9)	22(26.2)	15(17.9)
Chemotherapy group	19(22.6)	8(9.5)	1(1.2)	0(0)

Chinese medicine adds chemotherapy group

43(51.2)

35(41.7)

24(28.6)

18(21.4)

Can know that through table 3 Chinese medicine preparation of the present invention can obviously improve the life span of Pancreas cancer patients, improve clinical cure patient's ratio, increase the therapeutic effect of chemotherapy and the side effect of minimizing chemotherapy simultaneously; Chinese drug-treated group and Chinese medicine add chemotherapy group, compare with chemotherapy group, have significant difference.

Model case:

Zhang, man, 68 years old.Patient's body constitution is strong, plain no chronic disease.Upper left abdomen dull pain between in January, 2004, in time, end when doing, and very do not mind.The pain increased at the beginning of 3 months, is impatient at sometimes, begins to hospital admission.Mid-March to hospital CT examination, report: " 1. gallbladder increases, cholecystitis.2. the uncinate process of pancreas occupy-place maybe." the tentative diagnosis suggestion is cancer of pancreas.The suggestion excision, the patient is high seriously ill and refuse with year, introduces decision through the friend and adopts treatment by Chinese herbs.The first visit of late March to here, patient's cardinal symptom at that time is malaise and upper left abdomen pain, its characteristics are felt more than pain for expanding.Very feel bad when expanding urgency, uneasy in either sitting or lying, and mechanism of qi is arranged from ambition, pushing up on the umbilicus.The pain paroxysm, severe pain can cause groan sometimes.Stomach receive still can, self-regulated convenient to both.No heating and gallbladder, the intestines and stomach symptom.Large pulse is not smooth, one expiration and inspiration four to.Body of the tongue is light red, white and thin fur and be bored with the tongue light yellow complexion.Arteries and veins disease is strong for deficiency of vital energy spleen fortune in view of the above, and expectorant is turbid is detained and QI and blood is handed over and coagulated, and it is long-pending to become abdominal mass, holds poison for a long time to become to dislike disease.The side is with the tablet that contains of the embodiment of the invention 1, and every day three times, each 3, behind three first quarter moons of taking medicine, the patient is with transference cure, and slight illness is alleviated and drug withdrawal voluntarily.To August next year, drug withdrawal is ten April, are in hospital because of upper abdomen severe pain again.Be diagnosed as the gallbladder inflammatory swelling, the excision of performing a surgical operation.Give inspection pancreas after cutting open the belly earlier, seeing has the cancerous protuberance of atrophy focus.Confirm that the patient is strictly cancer of pancreas original suffering from, and also confirms that treatment by Chinese herbs has made recovery from illness.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.

Claims

1. Chinese medicine composition of treating cancer of pancreas; It is characterized in that its raw medicinal material comprises: Herba Sarcandrae, Zaocys, Herba Scutellariae Barbatae, Herba Lobeliae Chinensis, Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Violae, Herba Patriniae, Flos Lonicerae, Fructus Forsythiae, Radix Glycyrrhizae, Herba Lophatheri, Herba Artemisiae Scopariae, Radix Codonopsis, Fructus Gardeniae, Radix Et Rhizoma Rhei, Semen Coicis, Caulis Sargentodoxae, Fructus Mume, Borneolum Syntheticum, Herba Lysimachiae, Polyporus, Fructus Galangae, Rhizoma Curcumae Longae, Rhizoma Acori Graminei, Fructus Lycii, Rhizoma Belamcandae, Radix Paeoniae Rubra and Radix Trichosanthis.

2. Chinese medicine composition as claimed in claim 1 is characterized in that: the ratio of weight and number of the raw medicinal material in the said Chinese medicine composition is: Herba Sarcandrae 20～35 weight portions, Zaocys 8～15 weight portions, Herba Scutellariae Barbatae 12～15 weight portions, Herba Lobeliae Chinensis 15～30 weight portions, Herba Hedyotidis Diffusae 20～30 weight portions, Herba Taraxaci 30～50 weight portions, Herba Violae 25～40 weight portions, Herba Patriniae 18～30 weight portions, Flos Lonicerae 35～50 weight portions, Fructus Forsythiae 10～20 weight portions, Radix Glycyrrhizae 20～35 weight portions, Herba Lophatheri 20～30 weight portions, Herba Artemisiae Scopariae 15～25 weight portions, Radix Codonopsis 16～34 weight portions, Fructus Gardeniae 15～20 weight portions, Radix Et Rhizoma Rhei 10～15 weight portions, Semen Coicis 20～40 weight portions, Caulis Sargentodoxae 15～30 weight portions, Fructus Mume 20～35 weight portions, Borneolum Syntheticum 25～30 weight portions, Herba Lysimachiae 15～25 weight portions, Polyporus 20～35 weight portions, Fructus Galangae 20～45 weight portions, Rhizoma Curcumae Longae 15～2 () weight portion, Rhizoma Acori Graminei 10～15 weight portions, Fructus Lycii 25～35 weight portions, Rhizoma Belamcandae 18～25 weight portions, Radix Paeoniae Rubra 15～25 weight portions and Radix Trichosanthis 30～50 weight portions.

3. according to claim 1 or claim 2 Chinese medicine composition, it is characterized in that: the ratio of weight and number of the raw medicinal material in the said Chinese medicine composition is: Herba Sarcandrae 25～30 weight portions, Zaocys 10～15 weight portions, Herba Scutellariae Barbatae 12～15 weight portions, Herba Lobeliae Chinensis 15～20 weight portions, Herba Hedyotidis Diffusae 20～25 weight portions, Herba Taraxaci 30～40 weight portions, Herba Violae 30～35 weight portions, Herba Patriniae 20～25 weight portions, Flos Lonicerae 35～45 weight portions, Fructus Forsythiae 15～20 weight portions, Radix Glycyrrhizae 20～30 weight portions, Herba Lophatheri 20～25 weight portions, Herba Artemisiae Scopariae 15～20 weight portions, Radix Codonopsis 20～30 weight portions, Fructus Gardeniae 15～20 weight portions, Radix Et Rhizoma Rhei 10～15 weight portions, Semen Coicis 20～30 weight portions, Caulis Sargentodoxae 15～25 weight portions, Fructus Mume 20～30 weight portions, Borneolum Syntheticum 28～30 weight portions, Herba Lysimachiae 20～25 weight portions, Polyporus 30～35 weight portions, Fructus Galangae 30～40 weight portions, Rhizoma Curcumae Longae 15～28 weight portions, Rhizoma Acori Graminei 10～12 weight portions, Fructus Lycii 30～35 weight portions, Rhizoma Belamcandae 20～25 weight portions, Radix Paeoniae Rubra 20～25 weight portions and Radix Trichosanthis 30～40 weight portions.

4. like the described Chinese medicine composition of claim 1 to 3, it is characterized in that: the ratio of weight and number of the raw medicinal material in the said Chinese medicine composition is: Herba Sarcandrae 28 weight portions, Zaocys 12 weight portions, Herba Scutellariae Barbatae 15 weight portions, Herba Lobeliae Chinensis 15 weight portions, Herba Hedyotidis Diffusae 22 weight portions, Herba Taraxaci 35 weight portions, Herba Violae 32 weight portions, Herba Patriniae 23 weight portions, Flos Lonicerae 40 weight portions, Fructus Forsythiae 18 weight portions, Radix Glycyrrhizae 25 weight portions, Herba Lophatheri 20 weight portions, Herba Artemisiae Scopariae 15 weight portions, Radix Codonopsis 26 weight portions, Fructus Gardeniae 15 weight portions, Radix Et Rhizoma Rhei 15 weight portions, Semen Coicis 25 weight portions, Caulis Sargentodoxae 20 weight portions, Fructus Mume 30 weight portions, Borneolum Syntheticum 30 weight portions, Herba Lysimachiae 20 weight portions, Polyporus 30 weight portions, Fructus Galangae 35 weight portions, Rhizoma Curcumae Longae 20 weight portions, Rhizoma Acori Graminei 10 weight portions, Fructus Lycii 35 weight portions, Rhizoma Belamcandae 25 weight portions, Radix Paeoniae Rubra 20 weight portions and Radix Trichosanthis 35 weight portions.

5. like the described Chinese medicine composition of claim 1 to 4, it is characterized in that: the raw medicinal material of said Chinese medicine composition also further comprises Poria 15～20 weight portions, Radix Ginseng 25～35 weight portions and the Rhizoma Atractylodis Macrocephalae 20～30 weight portions.

6. like the described Chinese medicine composition of claim 1 to 5, it is characterized in that: the raw medicinal material of said Chinese medicine composition also further comprises Poria 18 weight portions, Radix Ginseng 30 weight portions and the Rhizoma Atractylodis Macrocephalae 25 weight portions.

7. like the method for preparing of the described Chinese medicine composition of claim 1 to 6, it is characterized in that:

When the dosage form of said Chinese medicine composition when containing tablet, it may further comprise the steps,

8. the method for preparing of the described Chinese medicine composition of claim 1 to 6 is characterized in that:

When the dosage form of said Chinese medicine composition was syrup, it may further comprise the steps,

9. the method for preparing of the described Chinese medicine composition of claim 1 to 6 is characterized in that:

When the dosage form of said Chinese medicine composition was capsule, it may further comprise the steps,