CN104888174A - Medicinal preparation for treating deficiency cold of spleen and stomach type peptic ulcer and preparation method thereof - Google Patents

Abstract

The invention discloses a medicinal preparation for treating deficiency cold of spleen and stomach type peptic ulcer and a preparation method thereof. The medicinal preparation comprises the following crude drugs: brassica oleracea, lepisorus waltonii, rhizoma zingiberis, hyoscyamus, cortex cinnamomi, clarified butter, fructus foeniculi, fructus ulmi macrocarpae, syzygium aromaticum, pepper, schisandra propinqua, fructus piperis longi, dried tangerine or orange peel, notopterygium root, radix aucklandiae, cayratia japonica, santalum album, semen litchi, potentilla chinensis, prunus mume, allium macrostemon, cucurbita moschata duch, herba aristolochiae, calcicola aristolochia root, rhizoma nardostachyos, diospyros kaki receptacle, valeriana officinalis, medicated leaven, cathay quince, rice-grain sprouts, Japanese pollia herb, semen raphani, resina ferulae, areca catechu, desmodium pulchellum, astragalus membranaceus, rhizoma atractylodis macrocephalae, common crapemyrtle leaves, Chinese yam, pyrola rotundifolia, white hyacinth beans, rhodiola rosea and hippophae rhamnoides. The medicinal preparation for treating deficiency cold of spleen and stomach type peptic ulcer has the efficacies of warming the middle-jiao and invigorating the spleen, and regulating stomach to relieve pain, has the major function of treating deficiency cold of spleen and stomach type peptic ulcer, can not only reduce gastric acid secretion, but also promote ulcer healing and protect gastric mucosa, and is short in treatment course, free of toxic and side effect and obvious in curative effect.

Description

A kind ofly treat pharmaceutical preparation of spleen-stomach deficiency-cold peptic ulcer and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind ofly treat pharmaceutical preparation of spleen-stomach deficiency-cold peptic ulcer and preparation method thereof.

Background technology

Peptic ulcer mainly refers to betide the duodenal chronic ulcer of harmonization of the stomach, is a frequently-occurring disease, commonly encountered diseases.Ulcer be formed with various factors, wherein the Digestion of acidic gastric juice to mucosa is the Fundamentals of ulcer, hence obtains one's name.Any position of acidic gastric juice contact, as distal esophagus, the postoperative anastomotic stoma of gastrointestinal anastomosis, jejunum and the Meckel diverticulum with Ectopic Gastric Mucosa, most ulcer betides duodenum stomach function regulating, therefore also known as taste-blindness rate.

The etiology and pathogenesis of peptic ulcer in the traditional Chinese medical science: the cause of disease of stomachache is mainly diseases caused by exogenous pathogenic factor cold-evil, injury due to diet, and feelings will is unsuccessful, weakness of the spleen and stomach etc.1. cold-evil visitor stomach, cold belongs to YIN pathogen, and its property stagnates spasm.Gastral cavilty top communicates with the external world with mouth, very cold, and cold-evil inhales people by mouth, or gastral cavity abdomen is suffered from cold, cold-evil's direct attack, and interior visitor in stomach, or takes medicine bitter cold too, or cold food damaging the spleen and stomach, and cause QI stagnated by cold, gastric qi is become estranged, and gastric qi blocks, stagnation of QI and blood may bring about pain.Said as " Plain Questions lifts a pain opinion section ": " between the intestines and stomach, under film is former, blood must not fall apart cold visitor, and little network is anxious to be drawn, therefore pain." 2. diet injure one's stomach, stomach receiving food and drink digesting food, its gas with reduce to suitable, therefore stomachache generation and eating and drinking without temperance relation the closest.If eating and drinking without temperance, eating and drinking too much at one meal, impairing the spleen and stomach, retention of food and drink, causes gastric qi to be become estranged, mechanism of qi retardance in stomach, stagnation of QI and blood may bring about pain; Or the five tastes cross pole, pungent immoderate, or addiction to greasy and sweet foods savoury, or drink as slurry, then the impairment of the spleen hinders stomach, accumulates humidogene heat, retardance mechanism of qi, so that gastric qi retardance, and stagnation of QI and blood may bring about pain, all can cause stomachache.Therefore " Plain Questions, a numbness opinion section " is said: " eating twice as usual, the intestines and stomach is wound." " medical science main story, gastric abscess " say: " and just cause a disease by, how because of self-indulgent food, it is sad to like, and throw off restraint the hot wine of drink and decoct torch, cold and cool raw food of eating again, damage dusk towards wound, it is dark that day amasss the moon ... therefore gastralgia." 3. hyperactive liver-QI attacking the stomach, the lifting being received transporting, middle burnt mechanism of qi of taste, depend on the catharsis of liver, " Plain Questions, a precious life holotype opinion section " said " earth being dredged by wood " namely means this.So pathology just there will be wood prosperous gram of soil, or change of deficient earth being subjugated by wood.Be worried angry, feelings will is unsuccessful, the liver failing to maintain the normal flow of QI, stagnation of QI due to depression of the liver, and perverse and unreasonable manner violates stomach, so that gastric qi is become estranged, and gastric qi blocks, and can send out as stomachache.So " miscellaneous diseases source and course rhinoceros is lit up, gastropathy source and course " meaning: " stomachache, evil dry gastral cavilty disease also.Only irritability is multiplied for more so, sudden and violent with wood, and just gram also." stagnation of liver-QI with the passing of time, again can fire-transformation heat-dissipating, heat invading the stomach, causes syndrome of liver-stomach heat and pain.If the liver failing to maintain the normal flow of QI, functional activity of QI being not smooth, the blood stasis of blood is stagnant, can form blood stasis again, doublely sees that blood stasis is had a stomachache.Gallbladder and liver phase the exterior and the interior, all belong to wood.Gallbladder leading to falls, and the transporting and the stomach sum that contribute to spleen are fallen." Ling Shu Miraculous Pivot or Divine Axis, four seasonal epidemic pathogens " are said: " evil in gallbladder, inverse at stomach." if gallbladder disease loses in catharsis, gallbladder internal organs is logical to fall not normal, and courage is not fallen, the criminal's of driving in the wrong direction stomach, causes gastric qi and becomes estranged, and the retardance of liver and gall gastric qi machine, also can have a stomachache.4. weakness of the spleen and stomach, spleen and stomach phase the exterior and the interior, with placed in the middle burnt, play altogether and received the merit of transporting and transforming nutrients from foodstuff.Splenic qi tending to ascend, stomach-QI being apt to descend, being received of stomach is become thoroughly decomposed, and rely the transporting the lucid yang sending up of spleen, so gastropathy is often involved in spleen, the splenopathy is often involved in stomach.If ferritic is not enough, or overstrain, or injury due to diet, or excessively take cold and cool medicine, or prolonged illness taste are impaired, all can cause weakness of the spleen and stomach, deficiency-cold in middle-JIAO, cause stomach to lose replenishing vital QI with drugs of warm nature, have a stomachache.If consumption of YIN caused by febrile disease, or gastric heat fire stagnation, stomach-Yin of burning, or take fragrant dry crystalline substance of regulating the flow of vital energy for a long time, consume the moon that injures one's stomach, stomach mistake is moistened foster, also can cause stomachache.The kidney being the origin of congenital constitution, root of YIN and YANG, the sun of taste, entirely relies the warm of kidney yang; The moon of taste, the full nourishing relying kidney yin.If insufficiency of kidney-YANG, the not warm soil of fire, can cause deficiency of spleen-YANG, form deficiency of spleen-YANG and kidneyYANG, stomach loses the stomachache of replenishing vital QI with drugs of warm nature; If deficiency of kidney-YIN, kidney water can not go up Ji stomach-Yin, can cause deficiency of stomach-YIN, forms stomach deficiency of the kidney yin.Stomach loses and moistens foster stomachache.

In addition, if the stagnation of QI with the passing of time, the blood stasis of blood is stagnant, or pain people network of a specified duration, and stomach network is obstructed, or after gastrorrhagia, blood circulating out of vessels does not eliminate, so that stops in blood stasis, and the retardance of stomach network is obstructed, and blood stasis all can be caused to have a stomachache." Linzheng Zhinan Yi gastric abscess " has the discussion about this pathogenesis already: " stomachache is sent out for a long time and repeatly, and solidifying expectorant must be had to gather the stasis of blood.If " spleen YANG deficiency, lose in strong fortune, endogenous dampness, the poly-expectorant that wets into becomes drink, accumulation gastral cavilty, can cause again phlegm retention stomachache.

Analyze the cause of disease of peptic ulcer, its clinical syndrome can be divided into: 1. cold-evil visitor gastric pattern: stomachache is done cruelly, and very then contracture is had a pain, pain alleviated while getting warmth, pain increase in intensity under coldness, tastelessness and no thirst, or desire for hot drinks, white and thin fur, stringy and tense pulse.Method for the treatment of: warming stomach for dispelling cold, regulating QI to relieve pain.2. diet-stasis: after eating and drinking too much at one meal, gastralgia, distension does not disappear, pain with tenderness, obtains food more very, belching and acid regurgitation, or vomiting indigestion food, its taste is rancid, tells rear alleviation of pain, anorexia or anorexia, defecate not well, must vow gas and slightly easypro after an action of the bowels, thick fur is greasy, and rolling pulse is strong.。3. hyperactive liver-qi attacking the stomach: gastral cavilty distension, attacks support and has a pain, and gastralgia connects the side of body, belch uncomfortable in chest, and happiness is sighed breath, and stool is smooth, obtains belch, vows that gas then relaxes, meet worried disgruntled then pain do or pain very, white and thin fur, stringy pulse.4. liver stomach wind-cold type: burning pain in the epigastrium, pain gesture is urgent, and like cold aversion to heat, obtain cool, relax, susceptible to lose temper due to restlessness, pantothenic acid is noisy, dry mouth with bitter taste, the few tongue of red tongue, wiry and frequent pulse.5. blood stasis stationary form: gastralgia, aching as needle stabbing lancinates, localized pain, the pain of pressing very, aggravation after food, becoming severe at night, or see haematemesis, melena, purplish tongue or have ecchymosis, hesitant pulse.6. spleen and stomach damp-heat type: the scorching hot pain of gastral cavilty, noisy pantothenic acid, dry mouth with bitter taste, thirst but no desire to drink, sweet taste in the mouth glues turbid, and food sweet food then emits sour water, and indigestion and loss of appetite nauseating, heavy sensation of the body limb is tired, urine yellow skin, and stool is smooth, yellowish fur, the sliding number of pulse condition.7. stomach-yin deficiency: the indistinct causalgia of gastral cavilty, the loss of appetite like famine, dryness of the mouth and throat, thirsty think of drink, becomes thin weak, constipation with dry stool, red tongue with a little fluid or light stripping no fur, thready and rapid pulse.8. spleen-stomach deficiency-cold: stomachache is indistinctly, endlessly continuous, cold type of pain is uncomfortable, and like warm cream and press, pain of empty stomach very, obtains food and then delays, tired or eat cold or panic attacks or increase the weight of, general vomiting watery fluid, lack of appetite, spiritlessness and weakness, hands and feet being not warm after suffering from cold, and large loose stool is thin, pale tongue with white fur, deficient and weak pulse.Western medical treatment peptic ulcer mainly comprises the following aspects: 1. live: peptic ulcer belongs to typical psychosomatic disease category, psychology-social factor plays an important role to morbidity, therefore, optimistic emotion, the life of rule, avoid hypertonicity with tired, no matter the stage of attack of primary disease or the catabasis all very important.When ulcer active stage, when symptom is heavier, lie up several days and even 1 ~ 2 week.2. diet: before bisfentidine comes out, dietetic therapy was once the only or main treatment means of peptic ulcer.1901, Lenhartz pointed out to have more meals a day but less food at each favourable to patient.Thereafter, Sippy dietetic therapy comes out, and is continued to use clinically for many decades always.Sippy diet primarily of milk, egg, butter composition, further comprises the non-irritating food of " soft " later, its principle be these foods can dilute enduringly and in and gastric acid.Following viewpoint is held to the diet of Peptic Ulcers: 1. chew carefully and swallow slowly, avoids anxious food, chew and can ptyalize, the latter can dilute and in and gastric acid, and may have and improve Mucosa Barrier effect; 2. regular timing eating, to maintain the rhythm and pace of moving things of normal stool activity; 3. when acute active stage, be advisable to have many meals but little food at eath, have meal every day 4 ~ 5 times, but as soon as symptom is controlled, one day 3 meal comparatively fast returned at ordinary times should be encouraged; 4. diet should note nutrition, but without the need to specifying special recipe; 5. avoid snacks between meal, should not take food before sleeping; 6. in acute active stage, answer wine for giving off smoking, and avoid zest flavoring agent or the pungent beverages such as coffee, strong tea, soup stock and Fructus Capsici vinegar, and the medicine of damage gastric mucosa; 7. diet insatiety, increases the secretion of gastrin to prevent the overdistension in gastric antrum portion.3. calm: to the patient of minority with symptoms such as anxiety, anxiety, insomnias, can some tranquilizers of short-period used or tranquilizer.4. avoid application to cause medicine for ulcer: patient should be tried to stop and stop using and bring out or cause Peptic Ulcers to increase the weight of or the relevant medicine of bleeding, comprise: 1. Salicylate and nonsteroid anti-inflammatory drugs (NSAIDs); 2. adrenocortical hormone; 3. reserpine etc.If tired rheumatism or rheumatoid disease must use said medicine, enteric dosage form or low dose of interruption should be adopted to apply as far as possible.Carry out sufficient antiacid treatment simultaneously and strengthen mucosa protection agent.

But western medical treatment peptic ulcer, therapeutic scheme is single, and the course for the treatment of is longer, and prolonged application antibiotic toxic and side effects is more, and easily produces drug resistance, and prolonged application medicine brings certain mental pressure to patient, and clinical efficacy is not satisfactory.

Summary of the invention

Technical problem to be solved by this invention is, there is provided a kind of and treat pharmaceutical preparation of spleen-stomach deficiency-cold peptic ulcer and preparation method thereof, the present invention has warming middle-JIAO and strengthening the spleen, with effect of stomach and alleviating pain, cure mainly spleen-stomach deficiency-cold peptic ulcer, not only there is reduction gastric acid secretion, Promotive union ulcer, protection gastric mucosa, also there is treatment short treating period, have no side effect, evident in efficacy, not easily produce the feature of drug resistance, immunity of organisms can also be improved while treatment peptic ulcer, the ability of the defence pathogenic factor of enhancing body, convenient drug administration, mouthfeel is suitable for, patient is easy to accept, more the advantage not easily recurred after.

In order to realize foregoing invention object, the invention provides a kind of pharmaceutical preparation for the treatment of spleen-stomach deficiency-cold peptic ulcer, wherein, comprise following raw medicinal material: Corm Brassicae caulorapae, Pyrrosia hastata (Thunb.) Ching, Rhizoma Zingiberis, hyoscyami, Cortex Cinnamomi, milk, Fructus Foeniculi, Fructus Ulmus preparatium, Flos Caryophylli, Fructus Piperis, Cortex cynoglossi zeylanici radicis, Fructus Piperis Longi, Pericarpium Citri Reticulatae, Rhizoma Et Radix Notopterygii, the Radix Aucklandiae, Herba Cayatiae Japonicae, Lignum Santali Albi, Semen Litchi, Herba Potentillae Chinensis, FLOS MUME, Bulbus Allii Macrostemonis, the Plantula cucurbitae moschatae, Herba Aristolochiae, Radix Aristolochiae, Radix Et Rhizoma Nardostachyos, Calyx Kaki, Rhizoma et radix valerianae, Massa Medicata Fermentata, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd., Fructus Oryzae Germinatus, Rhizoma Polliae Japonicae, Semen Raphani, Resina Ferulae, Semen Arecae, Ramulus et Folium Phyllodii Pulchelli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Folium Lagerstroemiae Indicae, Rhizoma Dioscoreae, from thing mouth grass, Semen Lablab Album, Radix Rhodiolae and Fructus Hippophae.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 14 ~ 32 parts, Pyrrosia hastata (Thunb.) Ching 10 ~ 27 parts, Rhizoma Zingiberis 16 ~ 34 parts, hyoscyami 17 ~ 35 parts, Cortex Cinnamomi 10 ~ 28 parts, milk 12 ~ 32 parts, Fructus Foeniculi 10 ~ 25 parts, Fructus Ulmus preparatium 7 ~ 22 parts, Flos Caryophylli 9 ~ 24 parts, 10 ~ 21 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 10 ~ 24 parts, Fructus Piperis Longi 16 ~ 28 parts, Pericarpium Citri Reticulatae 15 ~ 27 parts, Rhizoma Et Radix Notopterygii 16 ~ 29 parts, the Radix Aucklandiae 17 ~ 34 parts, Herba Cayatiae Japonicae 16 ~ 32 parts, 18 ~ 27 parts, Lignum Santali Albi, Semen Litchi 14 ~ 26 parts, Herba Potentillae Chinensis 18 ~ 32 parts, FLOS MUME 15 ~ 26 parts, Bulbus Allii Macrostemonis 18 ~ 34 parts, the Plantula cucurbitae moschatae 16 ~ 29 parts, Herba Aristolochiae 15 ~ 35 parts, Radix Aristolochiae 16 ~ 31 parts, Radix Et Rhizoma Nardostachyos 18 ~ 32 parts, Calyx Kaki 18 ~ 31 parts, Rhizoma et radix valerianae 13 ~ 25 parts, Massa Medicata Fermentata 11 ~ 24 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 32 parts, Fructus Oryzae Germinatus 17 ~ 29 parts, Rhizoma Polliae Japonicae 14 ~ 32 parts, Semen Raphani 11 ~ 27 parts, Resina Ferulae 13 ~ 32 parts, Semen Arecae 10 ~ 32 parts, Ramulus et Folium Phyllodii Pulchelli 14 ~ 35 parts, the Radix Astragali 19 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Folium Lagerstroemiae Indicae 12 ~ 23 parts, Rhizoma Dioscoreae 17 ~ 27 parts, from thing mouth grass 1 ~ 2 part, Semen Lablab Album 8 ~ 31 parts, Radix Rhodiolae 19 ~ 34 parts and Fructus Hippophae 17 ~ 32 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 16 ~ 30 parts, Pyrrosia hastata (Thunb.) Ching 12 ~ 25 parts, Rhizoma Zingiberis 18 ~ 32 parts, hyoscyami 19 ~ 30 parts, Cortex Cinnamomi 18 ~ 26 parts, milk 17 ~ 29 parts, Fructus Foeniculi 14 ~ 24 parts, Fructus Ulmus preparatium 8 ~ 20 parts, Flos Caryophylli 11 ~ 22 parts, 14 ~ 20 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 13 ~ 21 parts, Fructus Piperis Longi 18 ~ 26 parts, Pericarpium Citri Reticulatae 19 ~ 25 parts, Rhizoma Et Radix Notopterygii 18 ~ 26 parts, the Radix Aucklandiae 19 ~ 32 parts, Herba Cayatiae Japonicae 17 ~ 26 parts, 19 ~ 24 parts, Lignum Santali Albi, Semen Litchi 15 ~ 25 parts, Herba Potentillae Chinensis 18 ~ 26 parts, FLOS MUME 16 ~ 24 parts, Bulbus Allii Macrostemonis 19 ~ 32 parts, the Plantula cucurbitae moschatae 17 ~ 27 parts, Herba Aristolochiae 16 ~ 33 parts, Radix Aristolochiae 17 ~ 30 parts, Radix Et Rhizoma Nardostachyos 19 ~ 31 parts, Calyx Kaki 19 ~ 30 parts, Rhizoma et radix valerianae 15 ~ 24 parts, Massa Medicata Fermentata 13 ~ 22 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 22 parts, Fructus Oryzae Germinatus 18 ~ 26 parts, Rhizoma Polliae Japonicae 15 ~ 30 parts, Semen Raphani 13 ~ 25 parts, Resina Ferulae 15 ~ 30 parts, Semen Arecae 15 ~ 30 parts, Ramulus et Folium Phyllodii Pulchelli 15 ~ 32 parts, the Radix Astragali 20 ~ 32 parts, the Rhizoma Atractylodis Macrocephalae 13 ~ 20 parts, Folium Lagerstroemiae Indicae 14 ~ 22 parts, Rhizoma Dioscoreae 18 ~ 24 parts, from thing mouth grass 1 ~ 2 part, Semen Lablab Album 9 ~ 26 parts, Radix Rhodiolae 22 ~ 33 parts and Fructus Hippophae 18 ~ 30 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 25 parts, Pyrrosia hastata (Thunb.) Ching 22 parts, Rhizoma Zingiberis 26 parts, hyoscyami 20 parts, Cortex Cinnamomi 19 parts, milk 24 parts, Fructus Foeniculi 15 parts, Fructus Ulmus preparatium 18 parts, Flos Caryophylli 17 parts, 16 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 19 parts, Fructus Piperis Longi 22 parts, Pericarpium Citri Reticulatae 24 parts, Rhizoma Et Radix Notopterygii 25 parts, the Radix Aucklandiae 27 parts, Herba Cayatiae Japonicae 24 parts, 22 parts, Lignum Santali Albi, Semen Litchi 19 parts, Herba Potentillae Chinensis 23 parts, FLOS MUME 21 parts, Bulbus Allii Macrostemonis 29 parts, the Plantula cucurbitae moschatae 25 parts, Herba Aristolochiae 32 parts, Radix Aristolochiae 18 parts, Radix Et Rhizoma Nardostachyos 24 parts, Calyx Kaki 26 parts, Rhizoma et radix valerianae 22 parts, Massa Medicata Fermentata 14 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 21 parts, Fructus Oryzae Germinatus 24 parts, Rhizoma Polliae Japonicae 26 parts, Semen Raphani 23 parts, Resina Ferulae 19 parts, Semen Arecae 20 parts, Ramulus et Folium Phyllodii Pulchelli 22 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Folium Lagerstroemiae Indicae 20 parts, Rhizoma Dioscoreae 23 parts, from thing mouth grass 2 parts, Semen Lablab Album 25 parts, Radix Rhodiolae 27 parts and Fructus Hippophae 26 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 28 parts, Pyrrosia hastata (Thunb.) Ching 18 parts, Rhizoma Zingiberis 24 parts, hyoscyami 32 parts, Cortex Cinnamomi 23 parts, milk 28 parts, Fructus Foeniculi 21 parts, Fructus Ulmus preparatium 20 parts, Flos Caryophylli 14 parts, 17 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 12 parts, Fructus Piperis Longi 24 parts, Pericarpium Citri Reticulatae 22 parts, Rhizoma Et Radix Notopterygii 26 parts, the Radix Aucklandiae 32 parts, Herba Cayatiae Japonicae 30 parts, 22 parts, Lignum Santali Albi, Semen Litchi 24 parts, Herba Potentillae Chinensis 25 parts, FLOS MUME 22 parts, Bulbus Allii Macrostemonis 28 parts, the Plantula cucurbitae moschatae 23 parts, Herba Aristolochiae 33 parts, Radix Aristolochiae 19 parts, Radix Et Rhizoma Nardostachyos 26 parts, Calyx Kaki 29 parts, Rhizoma et radix valerianae 22 parts, Massa Medicata Fermentata 20 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 26 parts, Fructus Oryzae Germinatus 25 parts, Rhizoma Polliae Japonicae 29 parts, Semen Raphani 24 parts, Resina Ferulae 28 parts, Semen Arecae 16 parts, Ramulus et Folium Phyllodii Pulchelli 32 parts, the Radix Astragali 33 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Folium Lagerstroemiae Indicae 21 parts, Rhizoma Dioscoreae 23 parts, from thing mouth grass 1 part, Semen Lablab Album 14 parts, Radix Rhodiolae 33 parts and Fructus Hippophae 30 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 19 parts, Pyrrosia hastata (Thunb.) Ching 23 parts, Rhizoma Zingiberis 32 parts, hyoscyami 33 parts, Cortex Cinnamomi 24 parts, milk 18 parts, Fructus Foeniculi 16 parts, Fructus Ulmus preparatium 9 parts, Flos Caryophylli 22 parts, 11 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 17 parts, Fructus Piperis Longi 22 parts, Pericarpium Citri Reticulatae 19 parts, Rhizoma Et Radix Notopterygii 26 parts, the Radix Aucklandiae 32 parts, Herba Cayatiae Japonicae 25 parts, 22 parts, Lignum Santali Albi, Semen Litchi 23 parts, Herba Potentillae Chinensis 19 parts, FLOS MUME 24 parts, Bulbus Allii Macrostemonis 32 parts, the Plantula cucurbitae moschatae 24 parts, Herba Aristolochiae 33 parts, Radix Aristolochiae 19 parts, Radix Et Rhizoma Nardostachyos 30 parts, Calyx Kaki 26 parts, Rhizoma et radix valerianae 24 parts, Massa Medicata Fermentata 22 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 26 parts, Fructus Oryzae Germinatus 25 parts, Rhizoma Polliae Japonicae 28 parts, Semen Raphani 25 parts, Resina Ferulae 23 parts, Semen Arecae 27 parts, Ramulus et Folium Phyllodii Pulchelli 33 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Lagerstroemiae Indicae 13 parts, Rhizoma Dioscoreae 17 parts, from thing mouth grass 2 parts, Semen Lablab Album 25 parts, Radix Rhodiolae 30 parts and Fructus Hippophae 26 parts.

Wherein, when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Wherein, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

The invention has the beneficial effects as follows: the present invention has warming middle-JIAO and strengthening the spleen; with effect of stomach and alleviating pain; cure mainly spleen-stomach deficiency-cold peptic ulcer; not only there is reduction gastric acid secretion; Promotive union ulcer; protection gastric mucosa, also has treatment short treating period, has no side effect; evident in efficacy; not easily produce the feature of drug resistance, can also immunity of organisms be improved, the ability of the defence pathogenic factor of enhancing body while treatment peptic ulcer; convenient drug administration; mouthfeel is suitable for, and patient is easy to accept, the advantage not easily recurred more.

Detailed description of the invention

The present invention treats spleen-stomach deficiency-cold peptic ulcer, follow warming middle-JIAO and strengthening the spleen, be primary treatment principle with stomach and alleviating pain, comprise following raw medicinal material: Corm Brassicae caulorapae, Pyrrosia hastata (Thunb.) Ching, Rhizoma Zingiberis, hyoscyami, Cortex Cinnamomi, milk, Fructus Foeniculi, Fructus Ulmus preparatium, Flos Caryophylli, Fructus Piperis, Cortex cynoglossi zeylanici radicis, Fructus Piperis Longi, Pericarpium Citri Reticulatae, Rhizoma Et Radix Notopterygii, the Radix Aucklandiae, Herba Cayatiae Japonicae, Lignum Santali Albi, Semen Litchi, Herba Potentillae Chinensis, FLOS MUME, Bulbus Allii Macrostemonis, the Plantula cucurbitae moschatae, Herba Aristolochiae, Radix Aristolochiae, Radix Et Rhizoma Nardostachyos, Calyx Kaki, Rhizoma et radix valerianae, Massa Medicata Fermentata, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd., Fructus Oryzae Germinatus, Rhizoma Polliae Japonicae, Semen Raphani, Resina Ferulae, Semen Arecae, Ramulus et Folium Phyllodii Pulchelli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Folium Lagerstroemiae Indicae, Rhizoma Dioscoreae, from thing mouth grass, Semen Lablab Album, Radix Rhodiolae and Fructus Hippophae.Wherein, Rhizoma Zingiberis, Cortex Cinnamomi, Fructus Foeniculi, Flos Caryophylli, Fructus Piperis, the pain relieving of Fructus Piperis Longi warming spleen and stomach for dispelling cold; Pericarpium Citri Reticulatae, the Radix Aucklandiae, Lignum Santali Albi, Semen Litchi, FLOS MUME, Bulbus Allii Macrostemonis, Herba Aristolochiae, Radix Et Rhizoma Nardostachyos, Calyx Kaki, Rhizoma et radix valerianae regulating QI to relieve pain; Massa Medicata Fermentata, Fructus Oryzae Germinatus, Semen Raphani, Resina Ferulae, Semen Arecae strengthening the spleen to promote digestion parasite killing; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Semen Lablab Album, Radix Rhodiolae, Fructus Hippophae invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Rhizoma Zingiberis: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.1. " herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI.2. " not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.3. " property of medicine opinion ": cure mainly nine types of precordial pain, kill three worms, main removing blood stasis, the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, except cough with dyspnea, stagnation of QI, gather around numbness, only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison.

Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet, return kidney, spleen, the heart, Liver Channel, " property of medicine opinion ": " cure mainly nine types of precordial pain, kill three worms, main removing blood stasis; the tonneau moon closes, and controls weak foot, numbness, meciless, retention of placenta, except cough with dyspnea; stagnation of QI, gather around numbness, and only cold air in abdomen, unbearably painful, main dysentery, nasal polyp.Herbicide wood poison." " Japan hanako materia medica ": " control all pathogenic wind, mend five kinds of strain and seven kinds of impairment, logical nine orifices, sharp joint, benefit essence, improving eyesight, warm waist knee joint, broken mass beside the umbilicus lump in the abdomen, repercussive blood, controls migratory arthralgia joint contracture, reuniting the fractured tendons and bones, granulation promoting meat." have mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, the cards such as heat in the upper and cold in the lower.

Fructus Foeniculi: acrid in the mouth, warm in nature; Enter kidney, bladder, stomach warp.There is stimulating appetite, cold expelling of regulating the flow of vital energy, have the effect in supporing yang road, cure mainly cold in middle-JIAO, loss of appetite, nausea and vomiting, abdominal part cold type of pain; Hernia pain, painful and swollen testis; Stagnation of QI in spleen and stomach, distension and fullness in the abdomen is had a pain.Fructus Foeniculi also has antiulcer, analgesia, gonadotropic Effect etc., and Oleum Anisi Stellati has antibacterial action in various degree.Energy stimulating gastrointestinal neural blood vessel, promotes saliva and gastric secretion, plays appetite stimulator, digestive effect.Be applicable to Deficiency and coldness of spleen and stomach.Intestinal colic, dysmenorrhea patient are used for dietetic therapy, and the side effect having deteriorated vision due to polyphagia Fructus Foeniculi produces.

Flos Caryophylli: sweet, pungent, hot greatly." Japan hanako materia medica ": " control implication, regurgitation, treat kidney qi, sensation of gas rushing, pain over the perineum, tonifying YANG, warm waist knee joint, kill alcoholism, disappear mass beside the umbilicus, except consumptive disease with cold nature." warming the stomach, the kidney warming.Control cold syndrome of the stomach pain with distension, singultus, vomiting and diarrhoea, arthralgia pain, colic, halitosis, toothache.Lilac water extract gavage, has obvious inhibitory action to mice water logging stress ulcer and rat hydrochloric acid gastric ulcer; Ether extract gavage, the rat gastric ulcer that can obviously suppress indometacin to add the mouse gastric ulcer of alcohol-induced and hydrochloric acid to cause.Eugenol is injected to rabbit vein, can produce anesthesia, blood pressure drops, respiration inhibition and obvious anticonvulsant action.A small amount of Oleum Caryophylli instillation dental caries chamber, existing disinfective action, also can destroy its nerve, thus ease toothache. and Flos Caryophylli can also cause uterine contraction.

Fructus Piperis: pungent, heat.Enter stomach, spleen, large intestine channel." Haiyao Bencao, Oversea Materia Medica ": " go the appetite deficiency of vital energy cold, dyspepsia does not disappear, cholera QI rising in reverse order, sudden attack of pain in the chest and abdomen, and cold air upper punch is gentle." can stomach invigorating take food, warming spleen and stomach for dispelling cold, pain relieving, Deficiency and coldness of spleen and stomach, vomiting, diarrhoea.The equal edible of population, digestive tract ulcer, cough spitting of blood, hemorrhoid, laryngopharyngitis, the careful food of eye disease patient.Piperine contained by this product, be less than under median lethal dose(LD 50) dosage, the rat and mouse caused galvanic shock, pentylenetetrazole, Picrotoxin, strychnine, tubocurarine and sodium glutamate is fainted from fear the antagonism all had in various degree, and the mortality rate of animal can be reduced, its effect has similarity with phenytoin Sodium, all obviously can resist electrofit.

Fructus Piperis Longi: pungent, heat.Return spleen channel, stomach warp, large intestine channel, lung meridian, urinary bladder channel, Liver Channel, kidney channel.Warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomit, have loose bowels, the toothache of migraine, nasal sinusitis, external treatment, coronary heart diseases and angina pectoris.Control trusted subordinate's cold type of pain, vomiting acid regurgitation, increased borborygmus and diarrhea, cold-dysentery, scrotal hernia, headache, nasal sinusitis, toothache.Volatile oil contained by these product to staphylococcus aureus, bacillus subtilis, Bacillus cereus, tubercule bacillus, dysentery bacterium, salmonella typhi T and B, yolk color eight folds bacterium etc. and influenza virus all has inhibitory action.Fructus Piperis Longi volatile oil can improve the hypoxia-bearing capability of mice under reduced pressure, Fructus Piperis Longi oil unsaponifiable matter significantly can also reduce the endogenous hypercholesterolemia mice serum T-CHOL and hepatic cholesterol content that feed 5% Adeps Sus domestica feedstuff brings out, the rising of the mice serum T-CHOL significantly suppressing Triton to bring out.

Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.

The Radix Aucklandiae: pungent is bitter, warm in nature; Return spleen, large intestine, tri-jiao channel.Compendium of Material Medica cloud: " Radix Aucklandiae is the medicine of three burnt edema caused by disorder of QI, can be elevated all gas.All gas Fen are strongly fragrant, all belong to lung, therefore the person of QI stagnating in upper-JIAO use, be golden Yu Ze let out also; Middle gas is not transported, and all belongs to spleen, therefore the person that QI stagnating in middle-JIAO is suitable, taste happiness fragrance is also; QI stagnation of the large intestine then weighs afterwards, and bladder gas does not change then infirmity pouring, and hepatic depression is then pain, therefore stagnation of QI in lower-JIAO person should it, the person that is plug logical also ".Effect: circulation of qi promoting, pain relieving, spleen invigorating, helps digestion.Cure mainly: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot, and abdominal distention, tells and have loose bowels, heavy after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.The Radix Aucklandiae pungent temperature perfume is loose, can rise and can fall, and leads to the gas of reason three Jiao, especially the gas of benefaction gastrointestinal and pain relieving, and have the merit of strengthening the spleen to promote digestion concurrently, caused by all taste QI stagnation of the large intestine, all cards are conventional product.

Lignum Santali Albi: pungent, temperature; Return spleen, stomach, the heart, lung meridian; Row heart warming middle-JIAO, appetizing pain relieving.External application can antiinflammatory be gone to swell, Glycerin; Smouldering can sterilizing, drives pestilence and wards off epidemic disease.The Oleum Santali albi extracted from sandalwood is pharmaceutically also having been widely used, there is the multi-efficiencies such as refrigerant, convergence, heart tonifying, nourishing, greasy skin, can be used to treatment bile sick, the disease such as cystitis, gonorrhea and stomachache, heating, vomiting, effective especially to be full of cracks, rich and honour hands, black speck, the mosquito disease such as to bite, be exactly to controlling dermopathic important medicine since time immemorial.Strengthen gastrointestinal peristalsis, the secretion of facilitating digestion liquid.Lignum Santali Albi liquid, to isolated frog heart perfusion, in negative inotropic action, has antagonism to decoction for Resuscitation, the poisoning caused arrhythmia of Cortex Acanthopancis; Oleum Santali albi has diuresis; Inhibitory action is had to dysentery bacterium, tubercule bacillus.

Semen Litchi: sweet, puckery, temperature.Return liver, stomach warp.Essentials of Matea Medica: " enter Liver and kidney, loose stagnant gas, wards off cold-evil, control gastric abscess, married woman's vim and vigour pain." Compendium of Material Medica: " the loose stagnant gas of row, controls swelling of the scrotum pain due to disorder of QI, married woman's vim and vigour pain." cold-dispelling pain-relieving, promoting QI to circulate and dispersing the agglomeration of the pathogens.For colic of cold type pain due to disorder of QI, painful and swollen testis, heart peratodynia, hernia, the long-pending stomachache of the women's Qi stagnation stasis of blood.This thing is given the mouse subcutaneous injection (60-400mg/kg) of hungry 22 hours, blood glucose can be made to decline, and liver glycogen content also significantly reduces.

FLOS MUME: sour and astringent, flat.Return liver, stomach, lung meridian.Supplementary Amplifications of the Compendium of Materia Medica: " " all sorts of flowers mirror ": powder for improving appetite is evil, and food of cooking congee, help the gas of sun clearly to rise, distillation point tea, promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizzy, scrofula.Stomachache due to hyperactive liver-QI attacking the stomach.The circulation of qi promoting of this product fragrance enters liver stomach, and energy dispersing the stagnated live-QI to relieve the stagnation of QI, is amusing, regulating the flow of Qi and the middle Jiao.

Bulbus Allii Macrostemonis: acrid in the mouth, hardship, warm in nature; Gui Jing, lung, the heart, stomach, large intestine channel." Mingyi Bielu ": " be attributed to bone.Except cold and heat, anhydrate gas, warming middle-JIAO eliminating stagnation.Wind and cold edema in all skin ulcers, to be coated with it." supplement to the Herbal: " in tune, main chronic diarrhea is not recovered, normal evil person in large abdomen, but cooks it more." have and regulate the flow of vital energy, the chest stuffiness relieving, activate yang, eliminating stagnation, effect of intestinal stasis relieving.Cure mainly the thorough back of the body of obstruction of qi in the chest and cardialgia, breast gastral cavity painful abdominal mass is vexed, cough with asthma abundant expectoration, epigastric pain, heavy after letting out dysentery, leucorrhea, furuncle carbuncle.Bulbus Allii Macrostemonis water decoction has suppression to dysentery bacterium, staphylococcus aureus.Bulbus Allii Macrostemonis can obviously disturb hematoblastic arachidonic acid metabolic, suppresses its Cycloxygenase metabolic pathway, suppresses the synthesis of TXB2 and HHT.The pungent loose hardship of these product is fallen, temperature is logical slides profit, and kind loose YIN-cold is to stagnate, and what lead to breast sun closes knot, for controlling the key medicine of the thoracic obstruction.Control thoracic obstruction card caused by cold-phlegm retardance, hypofunction of YANG QI in chest, the pungent row hardship of these product is fallen, and has the merit of circulation of qi promoting intestinal stasis relieving, relieving distension pain relieving.

Herba Aristolochiae: bitter, temperature; Enter liver,spleen,kidney warp." Bencao Tujing ": " Xie Fenglao.Herba Ephedrae then cures the wound cold diaphoresis, with Radix Et Rhizoma Rhei with taking gas." " book on Chinese herbal medicine is new again ": " removing heat from blood and promoting blood circulation, removes wind dampness removing, walks meridians, doublely controls the swollen pain of waist lower limb." circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Treat for stomachache, colicky, edema during pregnancy, puerperal, vim and vigour were suffered from abdominal pain, rheumatalgia.Promoting flow of QI and blood, pain relieving, diuresis.Edema during pregnancy, breast is suffered from abdominal pain, colic, rheumatalgia.Herba Aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable then peaceful, the inverse then vexed work of pain.As Young " side of directing at " Herba Aristolochiae controls the brachialgia of expectorant note, gas stays colic, and abdominal mass is gathered, and renal mass is suffered from abdominal pain, and puerperal, vim and vigour were suffered from abdominal pain, and he is as edema during pregnancy, edema over the face tachypnea, man's wind labor, and chronic cough is not healed, and knows and controls it with this medicine, peace of invariably getting into bed.Gai Weiqi is good at popular vim and vigour therefore also.See book discuss and cure mainly, only belong to the diseases such as pregnant edema during pregnancy, stomachache, wind consumptive disease, in his disease then not and here.Its reason controlled i.e., also only because bitter in the mouth master is in catharsis, warm in nature being led to lives, therefore passage of invigorating blood circulation, and makes water without unfavorable, and wind removes invariably, blood work invariably, and pain to be controlled therefore also all invariably with swollen.

Radix Et Rhizoma Nardostachyos: acrid in the mouth, sweet, warm in nature; Return spleen, stomach warp.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can open spleen, adds in taste medicine less, gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, the therapeutic method to keep the adverse QI flowing downwards." to have fragrance row loose for Radix Et Rhizoma Nardostachyos, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Cure mainly coldness and pain in the epigastrium distension, anorexia, chest pain, toothache, tumbling down is grieved, beriberi edema, cramp caused by acute vomiting and diarrhea.Jatamansi volatile oil has faint antibacterial, wind dispelling and spasmolysis, to skin, mucosa without local irritation.Jatamansi is to rabbit hemostasis, and rabbit performance is to the bradykinesia, sleepy, the loss of appetite that stimulate.Radix Et Rhizoma Nardostachyos alcohol extract has blood pressure lowering and antiulcer action.

Calyx Kaki: puckery, property is put down, and enters lung, spleen, stomach, large intestine channel.There are clearing heat and moistening lung, promoting the production of body fluid to quench thirst, effect of invigorating the spleen for dissipating phlegm; Be used for the treatment of cough due to lung-heat, thirsty, vomiting, diarrhea.Compendium of Material Medica: " cough with dyspnea person, gas chong channel under umbilicus is directly gone up to swallowing diaphragm, oh make a mistake, not smoothgoing inverse sound also." 0.5% Calyx kaki extract (ST) 50mg/kg lumbar injection in mice, can show and resist the room that chloroform brings out and quiver; Also can resist rat ventricular caused by aconitine, barium chloride, mouse peritoneal is injected, and spontaneous activity is obviously reduced, and strengthens the syngignoscism of sub-threshold dose pentobarbital sodium, extends its length of one's sleep, and the mice straub tail reaction that obvious antagonism morphine causes.Be in and exempt from antifertility screening, tentative confirmation Calyx Kaki has certain antifertility action, and Calyx Kaki handle is better than the Calyx Kaki base of a fruit, and the antifertility rate of the handle of Calyx Kaki is 79.6%.

Rhizoma et radix valerianae: pungent, sweet, warm; GUIXIN, Liver Channel.Medicine Rhizoma et radix valerianae has quelling to act on to central nervous system, can stabilize nerve when excited, then can help to refresh when fatigue.Rhizoma et radix valerianae epoxy three ester contained by Rhizoma et radix valerianae root can help to alleviate spasm and pain, contributes to relaxing neuropathic dyspepsia, stomach spasm or enteritis.Total alkaloids in Rhizoma et radix valerianae has antibacterial action, especially can resist the infection that gram-positive bacterium is caused.The pink flowers Rhizoma et radix valerianae of Rhizoma et radix valerianae can relieving insomnia, sleep disorder, flurried, anxiety neurosis and other disorder, also can relax one's muscles simultaneously, make environment oil recover stable state.

Massa Medicata Fermentata: nature and flavor are bitter, temperature.1. " property of medicine is examined ": " micro-bitter fragrant sweet." 2. " detailed outline is picked up any lost article from the road ": " and sweet light, delicate fragrance." enter spleen, stomach, large intestine channel.After flour, wheat bran and multi-medicament are mixed, through the herbal leaven of fermentation.Can strengthening the spleen to promote digestion, regulating QI to expel dampness, induces sweat.Cure the wound the food feeling of stuffiness in chest, and stomachache is vomited and diarrhoea, dysentery, headache due to common cold, and children's hinders hungry mistake and satisfies.Yeast is had in Massa Medicata Fermentata.Its composition has volatile oil, glycoside, fatty oil and vitamin B etc." Bencao Jingshu " is said: " ancients are bent, the song namely brewed alcoholic beverages, the sweet temperature of its abnormal smells from the patient, the special food stagnation removing of property, the stagnant gas of row taste, and loose internal organs are air-cooled.Massa Medicata Fermentata is that descendant specially makes, and with hyoscine, doubles in distillers yeast ".

Fructus Oryzae Germinatus: nature and flavor are sweet is flat.Return spleen, stomach warp, Liver Channel." Japan hanako materia medica ": " appetizing, only cholera, relieving restlessness, expectorant, broken crux, can expedite the emergence of tire for warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " anti-nausea, disappear dyspepsia, only acid regurgitation acid regurgitation, antidiarrheal, the wide diaphragm of the stomach that disappears, and control married woman's milk breast and do not receive, and milk is more than for alleviating distention in middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards." there is promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back effect of newborn relieving distension.Cure mainly food stagnation not disappear, abdominal distention, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders, distending pain of the breast, and women weans.Weakness of the spleen and stomach, transporting is unable, and causes food stagnation and not disappear person, increases the power of strengthening the spleen to promote digestion.Women breast-feeding their children should not use.

Semen Raphani: property is put down, acrid in the mouth, sweet; Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, distension and fullness in the abdomen, belch, heavy after dysentery, cough with copious phlegm, dyspnea with rapid and short breath fullness in the chest.Breath with cough for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots.Enter spleen, stomach, lung meridian, can help digestion de-swelling, and effect is remarkable, has the title of " rush wall fall wall ".Clinical habit is used for the treatment of real (eat, wet, stagnate) card.But these product are not only the de-swellings that helps digestion, and to deficiency syndrome with it, obtain effect also good, because of its property peace, its abnormal smells from the patient is not high again, and what without the fraud of victory partially, can not be limited to " rush wall fall wall " says there is the suspicion of dispelling the stagnated QI (being having a surplus of flat gas actually), and gives it up.Semen Raphani water extract has significant inhibitory action to staphylococcus and escherichia coli etc., and water extract has obvious hypotensive effect, for anesthetized rabbit, cat and dog, animal blood pressure all can be caused during intravenous injection to decline.

Resina Ferulae: bitter in the mouth, pungent, warm in nature, returns kidney, stomach warp, Tang Materia Medica: " mainly kill all small worms, gas of deodorizing, broken disease is amassed, lower bad odor." " Japan hanako materia medica ": " controls biography corpse, broken disease addiction, and cold air, wards off temperature, treating malaria, main cholera cardiac and abdominal pain of holding concurrently, kidney qi, warm miasma, all gill fungus dish poison imperial." there is removing food stagnancy, loose painful abdominal mass, effect of parasite killing, for meat stagnation, blood stasis lump in the abdomen, mass in abdomen, the cards such as abdominal pain due to worm stagnation.Resina Ferulae volatile oil aqueous emulsion can stop Anaphylactic mediator to discharge and mast cell degranulation, and the direct antagonizing histamine of energy and SRSA are to the contractile response of airway smooth muscle.After cutting from root of Resina Ferulae or rhizome, the rubber resin of gained and Resina Ferulae, have special foul smell, bitter in the mouth and pungent; Can from gastrointestinal tract, even if a large amount of (12 grams) are also without remarkable toxicity; Can be used as carminative (with 15 ~ 30 milliliters of coloclysis, simultaneously taking aperient), but should not use in 3 days after intestinal surgery.Its volatile oil is discharged from lung, therefore at bronchitis, pertussis or asthmatic patient, can be used as stimulant expectorant.

Semen Arecae: bitter in the mouth, pungent, warm in nature.Return stomach, large intestine channel.Have parasite killing, removing mass, sending down the abnormal ascending QI is capable stagnant, and row aquation wets.Effect.Cure mainly rapid digestion of food to relieve oedema or abdominal distension through diuresis or purgation, kill intestinal volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp nine orifices, relieving restlessness, caking in broken abdomen; Also can control beriberi, edema, chest pain, dysentery, abdominal distention is suffered from abdominal pain, defecation is unfavorable, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases.Compendium of Material Medica: " semen arecae goes out ridge table, the southern regions of the Yunnan Province, i.e. flat the and puckery person of a kind of enlarged abdomen shape in Semen Arecae, and not like the good ear of the Semen Arecae long taste of point, so-called pig Semen Arecae person is.Cover the different of also local products, moderns very do not distinguish." by Liu Xun " ridge table record " cloud, hand over, wide survivor, Semen Arecae on non-oceangoing ship, all semen arecae also, know in that and exhale as Semen Arecae, delicate and old, adopt and eat it in fact, with communicable subtropical diseases of dispelling, receive its skin and be used as medicine, the outer black of skin, Intradermal all muscle silk as Cortex cocois radicis (Cocos nucifera L.)." Yunnan note " cloud again, large abdomen Semen Arecae every has three, 200, cuts open it time blue or green, rolls up and eats it, namely subtract astringent taste with a slice betel leaf and Pulvis concha Mactrae.See this one to say, then semen arecae and Semen Arecae can be general, but the slightly bad ear of force rate Semen Arecae.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system for the Radix Astragali, soil in tonification.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.There is obvious and lasting diuresis, to various animal as rat, rabbit, Canis familiaris L. have effect.To not anaesthetizing Canis familiaris L. intravenous injection decoct 0.05-0.25g/kg, urine volume increase can reach more than 9 times, and medication after 5 hours still higher than normally.The Rhizoma Atractylodis Macrocephalae has obvious inhibitory action to platelet aggregation, Rhizoma Atractylodis Macrocephalae decoct 0.5g/kg gavage l-4 week, the time of energy significant prolongation rat prothrombing.The Rhizoma Atractylodis Macrocephalae has vasorelaxation action.Be inhibitory action to heart, can cause when dosage is excessive and stop winning, anesthetized dog intravenous injection decoct 0.1g/kg, blood pressure slightly decline 0.25g/kg time, blood pressure sharply declines, and has no recovery in 3-4 hour.

Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.

Semen Lablab Album: sweet light, tepor, flat; Return spleen channel, stomach warp.Spleen invigorating, removing dampness, relieves summer heat.Cure mainly insufficiency of the spleen resulting in production of dampness, anorexia and loose stool, leukorrhagia, heat-damp in summer is vomited and diarrhoea, and excessive thirst is uncomfortable in chest.。Semen Lablab Album control heat-damp in summer vomit and diarrhoea, summer heat usually accompanied with dampness, summer heat-damp in summer damaging the spleen and stomach, incoordination between the spleen and stomach, easily causes vomiting and diarrhoea.The invigorating the spleen for eliminating dampness of Semen Lablab Album energy with in.Syndrome of deficiency of spleen qi controlled by Semen Lablab Album, Semen Lablab Album energy QI invigorating with spleen invigorating, auxiliary using Semen Lablab Album as the medicine such as Radix Ginseng, the Rhizoma Atractylodis Macrocephalae.Semen Lablab Album also can be used for the leukorrhagia of insufficiency of the spleen turbid damp bet.The dull and stereotyped paper disk method of 100% Semen Lablab Album decoct, to dysentery bacterium and have inhibitory action; Detoxication is had to vomiting, acute gastroenteritis etc. that alimentary toxicosis causes.20% Semen Lablab Album cold salt immersion 0.3ml, is formed with facilitation to active E-rosette, namely strengthens the lymphocytic activity of T, improves the immunologic function of cell.Can distinguish the erythrocyte of people and sheep, cattle with the agglutinin that Semen Lablab Album extracts, because of the erythrocyte of the only coagulation people of agglutinin for this reason, legal medical expert can detect human blood with this.

Radix Rhodiolae: sweet is bitter, flat; Return lung, heart channel.Radix Rhodiolae is the dry root welding technology of crassulaceae plants Radix Rhodiolae, and effect of Radix Rhodiolae and effect are can the kidney invigorating, regulate the flow of vital energy and nourish blood, and has promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping, the side effect of Radix Rhodiolae does not temporarily find.Radix Rhodiolae energy improving water flood, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly to bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.Research points out that Oxidation is in a lot of advancing of disease process, plays very important role, such as cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc.In traditional medicine, Radix Rhodiolae is also for treating diabetes.Regarding assay utilizes mouse to make object, and test Radix Rhodiolae is movable to controlling the glycemic index of type-II diabetes, ferment and some antioxidative.

Fructus Hippophae: Fructus Hippophae and oil have very high medical value, can reduce cholesterol, and allevating angina pectoris shows effect, and prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can gastric duodenal ulcer and dyspepsia etc. be treated, evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Good therapeutical effect is had to burn, scald, cutter burning, cold injury; Good therapeutic effect is had to cervical erosion.Containing 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside, Quercetin, nimbecetin in sea buckthorn fruit, there is cough-relieving, the usefulness of eliminating the phlegm, expanding coronary vasodilator, reducing cholesterol of relievining asthma, be usually used in treating ischemic heart desease, 94% is reached to treatment angina pectoris effective percentage.In Fructus Hippophae, SOD active component enriches, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical because substance in vivo peroxidating produces, and the generation of this free radical and human senility, disease is closely related.

Ramulus et Folium Phyllodii Pulchelli: nature and flavor: lightly seasoned; Bitter; Property is put down.Gui Jing: lung; Spleen; Liver Channel.Cure mainly: heat-clearing and toxic substances removing; Expelling wind and promoting diuresis; Promoting blood circulation and detumescence.Main cold, fever; Laryngopharynx swelling and pain; Ulcerative gingivitis; Rheumatic arthralgia; Edema; Expand; Hepatosplenomegaly; Treating swelling and pain by traumatic injury; Insect-bite.

Corm Brassicae caulorapae: nature and flavor: Gan Xin is cool.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " acrid in the mouth is puckery." 2. " book on Chinese herbal medicine asks former ": " Gan Xin is cold, nontoxic." cure mainly: control stranguria with turbid discharge, stool hematochezia, toxic swelling, sinusitis with purulent discharge.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control insufficiency of the spleen fire to contain, middle diaphragm deposits expectorant, cold pain in abdomen, stranguria with turbid discharge; Control again the disease of leprosy mange; Eating raw quenches the thirst reduces phlegm, and large intestine hematochezia is controlled in decoction; Ashing is end, controls sinusitis with purulent discharge; Aphasia due to apoplexy is controlled in nasal insufflation.Skin can quench the thirst pouring." 2. " detailed outline is picked up any lost article from the road ": " separates carbon monoxide poisoning." 3. " book on Chinese herbal medicine asks former ": " the chest stuffiness relieving, relieves the effect of alcohol." the medicine Plantula cucurbitae moschatae: nature and flavor: warm in nature, slightly sweet flavor is nontoxic.Cure mainly: control intestinal colic in children and infantile convulsion, flu, rheumatic fever.

Pyrrosia hastata (Thunb.) Ching: nature and flavor: property is put down, bitter but sweet flavor.Cure mainly: relieving stranguria by diuresis, eliminating heat from the lung.Control oedema due to nephritis, urinary system infection, calculus of urethra, cough due to lung-heat, spitting of blood, bronchial asthma, the diseases such as pharyngolaryngitis.

Herba Potentillae Chinensis: nature and flavor: bitter, cold.Gui Jing: return liver, large intestine channel.Cure mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For bloody dysentery stomachache, chronic dysentery is more than, bleeding hemorrhoids, carbuncle sore tumefacting virus.

Fructus Ulmus preparatium: nature and flavor: toil, temperature.1. " herbal classic ": " acrid in the mouth is flat." 2. " property of medicine opinion ": " bitter in the mouth is pungent." 3. " Haiyao Bencao, Oversea Materia Medica ": " acrid in the mouth, temperature, nontoxic." return through: enter spleen, stomach warp, 1. " Thunder God concoct the property of medicine solution ": " enter lung, spleen two warp." 2. " beautiful Chinese catalpa medicine solution ": " enter to faint cloudy Liver Channel." 3. " key medicine divides agent ": " enters spleen, stomach two warp." 4. " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warp." cure mainly: parasite killing, removing food stagnancy.Control abdominal pain due to worm stagnation.Children's's infantile malnutrition with diarrhea, cold-dysentery, scabies, malignant boil.1. " herbal classic ": " pathogen in main five, in loose skin joint, excessive temperature row poison, goes three worms, relieving dyspepsia." 2. " not Lu ": ", by vain very little, in loose intestinal, Investigations-on Investigations-on pants.The main accumulation of pathogenic cold gas of " 3. " property of medicine opinion ": " energy, trusted subordinate's disease pain, except skin joint apoplexy is excessive in worm row." 4. the Meng numerous: " controls herpes simplex, pounds leaf fat and is coated with.Exudative dermatitis is controlled again with whitish honey.All skin ulcers are treated with husky cattle cheese.Long dietetic therapy five hemorrhoid.Pain due to disorder of QI in " 5. " Treatise on Dietetic Therapy ": " loose abdomen.Tinea can be controlled again with horse cheese.Kill again attacked by pestiferous factors insect poison." 6. " Haiyao Bencao, Oversea Materia Medica ": " controls the cold-dysentery motive, parasite killing pain relieving.Control again married woman uterus wind empty, child's infantile malnutrition with diarrhea." 7. " Japan hanako materia medica ": " controls hemorrhoidal hamorrhage anal fistula, malignant boil scabies." 8. " medical center bun is wanted ": " eliminating the pathogens from the lung method rheumatism, dry diabetes involving middle-JIAO cold food, control subcutaneous ulcer Huang, parasite killing goes ascarid." 9. " illustrated handbook planted by middle traditional Chinese medicines ": " diuresis of eliminating the phlegm."

Herba Cayatiae Japonicae: nature and flavor: bitter, sour, cold.Cure mainly: removing toxic substances and promoting subsidence of swelling, promoting blood circulation to remove blood stasis, diuresis, hemostasis.For laryngopharynx swelling and pain, corneal nebula, spitting of blood, hematuria, dysentery; Carbuncle is controlled in external, erysipelas, parotitis, traumatic injury, venom.

Hyoscyami: nature and flavor: (son) is bitter, cold, nontoxic.Cure mainly: 1, happen suddenly mania.With hyoscyami three liters, porphyrize, steeps several days in one liter of wine.Remove slag, decoct into extract.Divide in one day and drunk for three times.Seemingly have worm row as felt in head, namely forehead and the existing red point of trick are the phenomenons that disease soon will be good.

Milk: nature and flavor: 1. " a thousand pieces of gold dietetic therapy ": " sweet in the mouth is flat, nontoxic." 3. Tang Materia Medica: " property is cold." cure mainly: support battalion, YIN nourishing, moisturizes, and quenches the thirst.Control asthenia consumptive lung disease, spitting bloody pus, quench one's thirst, constipation, migratory arthralgia, skin pruritus.1. " a thousand pieces of gold dietetic therapy ": " tonify deficiency goes all migratory arthralgia.Remove eczema of the ear, add marrow invigorating middle warmer and fill out bone.The evil stagnated QI of " 2. Tang Materia Medica: " main air, logical profit bone marrow, can be the medicine that rubs, merit is better than shortcake." 3. " Japan hanako materia medica ": " spasmolytic is throbbed with fear, heat in the heart, headache, improving eyesight, applies the brain top heart." 4. amplification on Canon of Materia Medica: " profit supports scab." 5. " occupying diet spectrum with breath ": " moisturizes topping up YIN nourishing, resistance to famine of quenching the thirst, and supports battalion's heat clearing away."

Cortex cynoglossi zeylanici radicis: nature and flavor: sweet, pungent is flat.Cure mainly: expelling wind and activating blood circulation, removing toxic substances and promoting subsidence of swelling, pain relieving.Root: rheumatic numbness, traumatic injury, stomachache, menoxenia, rhomboembolia type straw is scorching; Leaf: furuncle is controlled in external, venom, traumatic hemorrhage.

Rhizoma Et Radix Notopterygii: nature and flavor: pungent, bitter, temperature.Gui Jing: return bladder, kidney channel.Cure mainly: cold expelling, dispel the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.

Radix Aristolochiae: nature and flavor: bitter, tepor.Cure mainly: circulation of qi promoting stomach invigorating, pain relieving.Treat for stomachache, traumatic injury.

Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd.: nature and flavor: sour and astringent is flat.1. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " the micro-acid of puckery." 2. the Meng numerous: " is flat." cure mainly: control convulsion of vomiting and diarrhoea, pantothenic acid of feeling sick, dysentery is Collective Notes to the Canon of Materia medica 1.: " disconnected dysentery." 2. the Meng numerous: " main cramp caused by acute vomiting and diarrhea, liquor eats it." 3. supplement to the Herbal: " removes feel sick acid pharynx, only wine expectorant yellow fluid."

Rhizoma Polliae Japonicae: nature and flavor: pungent, tepor.Cure mainly: regulating QI to relieve pain, dispelling wind and eliminating swelling.For breast side of body pain due to disorder of QI, stomachache, lumbago, head swells and ache, and sheds tears; Venom is controlled in external.

Folium Lagerstroemiae Indicae: cure mainly: control dysentery, eczema, wound hemorrhage.

From thing mouth grass: nature and flavor: sweet light.Cure mainly: control corneal nebula, jaundice.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 14 ~ 32 parts, Pyrrosia hastata (Thunb.) Ching 10 ~ 27 parts, Rhizoma Zingiberis 16 ~ 34 parts, hyoscyami 17 ~ 35 parts, Cortex Cinnamomi 10 ~ 28 parts, milk 12 ~ 32 parts, Fructus Foeniculi 10 ~ 25 parts, Fructus Ulmus preparatium 7 ~ 22 parts, Flos Caryophylli 9 ~ 24 parts, 10 ~ 21 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 10 ~ 24 parts, Fructus Piperis Longi 16 ~ 28 parts, Pericarpium Citri Reticulatae 15 ~ 27 parts, Rhizoma Et Radix Notopterygii 16 ~ 29 parts, the Radix Aucklandiae 17 ~ 34 parts, Herba Cayatiae Japonicae 16 ~ 32 parts, 18 ~ 27 parts, Lignum Santali Albi, Semen Litchi 14 ~ 26 parts, Herba Potentillae Chinensis 18 ~ 32 parts, FLOS MUME 15 ~ 26 parts, Bulbus Allii Macrostemonis 18 ~ 34 parts, the Plantula cucurbitae moschatae 16 ~ 29 parts, Herba Aristolochiae 15 ~ 35 parts, Radix Aristolochiae 16 ~ 31 parts, Radix Et Rhizoma Nardostachyos 18 ~ 32 parts, Calyx Kaki 18 ~ 31 parts, Rhizoma et radix valerianae 13 ~ 25 parts, Massa Medicata Fermentata 11 ~ 24 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 32 parts, Fructus Oryzae Germinatus 17 ~ 29 parts, Rhizoma Polliae Japonicae 14 ~ 32 parts, Semen Raphani 11 ~ 27 parts, Resina Ferulae 13 ~ 32 parts, Semen Arecae 10 ~ 32 parts, Ramulus et Folium Phyllodii Pulchelli 14 ~ 35 parts, the Radix Astragali 19 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Folium Lagerstroemiae Indicae 12 ~ 23 parts, Rhizoma Dioscoreae 17 ~ 27 parts, from thing mouth grass 1 ~ 2 part, Semen Lablab Album 8 ~ 31 parts, Radix Rhodiolae 19 ~ 34 parts and Fructus Hippophae 17 ~ 32 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 16 ~ 30 parts, Pyrrosia hastata (Thunb.) Ching 12 ~ 25 parts, Rhizoma Zingiberis 18 ~ 32 parts, hyoscyami 19 ~ 30 parts, Cortex Cinnamomi 18 ~ 26 parts, milk 17 ~ 29 parts, Fructus Foeniculi 14 ~ 24 parts, Fructus Ulmus preparatium 8 ~ 20 parts, Flos Caryophylli 11 ~ 22 parts, 14 ~ 20 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 13 ~ 21 parts, Fructus Piperis Longi 18 ~ 26 parts, Pericarpium Citri Reticulatae 19 ~ 25 parts, Rhizoma Et Radix Notopterygii 18 ~ 26 parts, the Radix Aucklandiae 19 ~ 32 parts, Herba Cayatiae Japonicae 17 ~ 26 parts, 19 ~ 24 parts, Lignum Santali Albi, Semen Litchi 15 ~ 25 parts, Herba Potentillae Chinensis 18 ~ 26 parts, FLOS MUME 16 ~ 24 parts, Bulbus Allii Macrostemonis 19 ~ 32 parts, the Plantula cucurbitae moschatae 17 ~ 27 parts, Herba Aristolochiae 16 ~ 33 parts, Radix Aristolochiae 17 ~ 30 parts, Radix Et Rhizoma Nardostachyos 19 ~ 31 parts, Calyx Kaki 19 ~ 30 parts, Rhizoma et radix valerianae 15 ~ 24 parts, Massa Medicata Fermentata 13 ~ 22 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 22 parts, Fructus Oryzae Germinatus 18 ~ 26 parts, Rhizoma Polliae Japonicae 15 ~ 30 parts, Semen Raphani 13 ~ 25 parts, Resina Ferulae 15 ~ 30 parts, Semen Arecae 15 ~ 30 parts, Ramulus et Folium Phyllodii Pulchelli 15 ~ 32 parts, the Radix Astragali 20 ~ 32 parts, the Rhizoma Atractylodis Macrocephalae 13 ~ 20 parts, Folium Lagerstroemiae Indicae 14 ~ 22 parts, Rhizoma Dioscoreae 18 ~ 24 parts, from thing mouth grass 1 ~ 2 part, Semen Lablab Album 9 ~ 26 parts, Radix Rhodiolae 22 ~ 33 parts and Fructus Hippophae 18 ~ 30 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 25 parts, Pyrrosia hastata (Thunb.) Ching 22 parts, Rhizoma Zingiberis 26 parts, hyoscyami 20 parts, Cortex Cinnamomi 19 parts, milk 24 parts, Fructus Foeniculi 15 parts, Fructus Ulmus preparatium 18 parts, Flos Caryophylli 17 parts, 16 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 19 parts, Fructus Piperis Longi 22 parts, Pericarpium Citri Reticulatae 24 parts, Rhizoma Et Radix Notopterygii 25 parts, the Radix Aucklandiae 27 parts, Herba Cayatiae Japonicae 24 parts, 22 parts, Lignum Santali Albi, Semen Litchi 19 parts, Herba Potentillae Chinensis 23 parts, FLOS MUME 21 parts, Bulbus Allii Macrostemonis 29 parts, the Plantula cucurbitae moschatae 25 parts, Herba Aristolochiae 32 parts, Radix Aristolochiae 18 parts, Radix Et Rhizoma Nardostachyos 24 parts, Calyx Kaki 26 parts, Rhizoma et radix valerianae 22 parts, Massa Medicata Fermentata 14 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 21 parts, Fructus Oryzae Germinatus 24 parts, Rhizoma Polliae Japonicae 26 parts, Semen Raphani 23 parts, Resina Ferulae 19 parts, Semen Arecae 20 parts, Ramulus et Folium Phyllodii Pulchelli 22 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Folium Lagerstroemiae Indicae 20 parts, Rhizoma Dioscoreae 23 parts, from thing mouth grass 2 parts, Semen Lablab Album 25 parts, Radix Rhodiolae 27 parts and Fructus Hippophae 26 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 28 parts, Pyrrosia hastata (Thunb.) Ching 18 parts, Rhizoma Zingiberis 24 parts, hyoscyami 32 parts, Cortex Cinnamomi 23 parts, milk 28 parts, Fructus Foeniculi 21 parts, Fructus Ulmus preparatium 20 parts, Flos Caryophylli 14 parts, 17 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 12 parts, Fructus Piperis Longi 24 parts, Pericarpium Citri Reticulatae 22 parts, Rhizoma Et Radix Notopterygii 26 parts, the Radix Aucklandiae 32 parts, Herba Cayatiae Japonicae 30 parts, 22 parts, Lignum Santali Albi, Semen Litchi 24 parts, Herba Potentillae Chinensis 25 parts, FLOS MUME 22 parts, Bulbus Allii Macrostemonis 28 parts, the Plantula cucurbitae moschatae 23 parts, Herba Aristolochiae 33 parts, Radix Aristolochiae 19 parts, Radix Et Rhizoma Nardostachyos 26 parts, Calyx Kaki 29 parts, Rhizoma et radix valerianae 22 parts, Massa Medicata Fermentata 20 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 26 parts, Fructus Oryzae Germinatus 25 parts, Rhizoma Polliae Japonicae 29 parts, Semen Raphani 24 parts, Resina Ferulae 28 parts, Semen Arecae 16 parts, Ramulus et Folium Phyllodii Pulchelli 32 parts, the Radix Astragali 33 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Folium Lagerstroemiae Indicae 21 parts, Rhizoma Dioscoreae 23 parts, from thing mouth grass 1 part, Semen Lablab Album 14 parts, Radix Rhodiolae 33 parts and Fructus Hippophae 30 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 19 parts, Pyrrosia hastata (Thunb.) Ching 23 parts, Rhizoma Zingiberis 32 parts, hyoscyami 33 parts, Cortex Cinnamomi 24 parts, milk 18 parts, Fructus Foeniculi 16 parts, Fructus Ulmus preparatium 9 parts, Flos Caryophylli 22 parts, 11 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 17 parts, Fructus Piperis Longi 22 parts, Pericarpium Citri Reticulatae 19 parts, Rhizoma Et Radix Notopterygii 26 parts, the Radix Aucklandiae 32 parts, Herba Cayatiae Japonicae 25 parts, 22 parts, Lignum Santali Albi, Semen Litchi 23 parts, Herba Potentillae Chinensis 19 parts, FLOS MUME 24 parts, Bulbus Allii Macrostemonis 32 parts, the Plantula cucurbitae moschatae 24 parts, Herba Aristolochiae 33 parts, Radix Aristolochiae 19 parts, Radix Et Rhizoma Nardostachyos 30 parts, Calyx Kaki 26 parts, Rhizoma et radix valerianae 24 parts, Massa Medicata Fermentata 22 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 26 parts, Fructus Oryzae Germinatus 25 parts, Rhizoma Polliae Japonicae 28 parts, Semen Raphani 25 parts, Resina Ferulae 23 parts, Semen Arecae 27 parts, Ramulus et Folium Phyllodii Pulchelli 33 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Lagerstroemiae Indicae 13 parts, Rhizoma Dioscoreae 17 parts, from thing mouth grass 2 parts, Semen Lablab Album 25 parts, Radix Rhodiolae 30 parts and Fructus Hippophae 26 parts.

Wherein, when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Wherein, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 1 injectable powder

The manufacturing process of injectable powder of the present invention is: get Corm Brassicae caulorapae 250g, Pyrrosia hastata (Thunb.) Ching 220g, Rhizoma Zingiberis 260g, hyoscyami 200g, Cortex Cinnamomi 190g, milk 240g, Fructus Foeniculi 150g, Fructus Ulmus preparatium 180g, Flos Caryophylli 170g, Fructus Piperis 160g, Cortex cynoglossi zeylanici radicis 190g, Fructus Piperis Longi 220g, Pericarpium Citri Reticulatae 240g, Rhizoma Et Radix Notopterygii 250g, Radix Aucklandiae 270g, Herba Cayatiae Japonicae 240g, Lignum Santali Albi 220g, Semen Litchi 190g, Herba Potentillae Chinensis 230g, FLOS MUME 210g, Bulbus Allii Macrostemonis 290g, Plantula cucurbitae moschatae 250g, Herba Aristolochiae 320g, Radix Aristolochiae 180g, Radix Et Rhizoma Nardostachyos 240g, Calyx Kaki 260g, Rhizoma et radix valerianae 220g, Massa Medicata Fermentata 140g, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 210g, Fructus Oryzae Germinatus 240g, Rhizoma Polliae Japonicae 260g, Semen Raphani 230g, Resina Ferulae 190g, Semen Arecae 200g, Ramulus et Folium Phyllodii Pulchelli 220g, Radix Astragali 300g, Rhizoma Atractylodis Macrocephalae 180g, Folium Lagerstroemiae Indicae 200g, Rhizoma Dioscoreae 230g, from thing mouth grass 20g, Semen Lablab Album 250g, Radix Rhodiolae 270g and Fructus Hippophae 260g,

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 7 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 hours under the condition of 10 DEG C, adopt percolation with the speed of 1.5ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 0.8 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 18g that second step obtains, adds propylene glycol 45g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 45 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 2 tablet

The manufacturing process of oral tablet of the present invention is: get Corm Brassicae caulorapae 280g, Pyrrosia hastata (Thunb.) Ching 180g, Rhizoma Zingiberis 240g, hyoscyami 320g, Cortex Cinnamomi 230g, milk 280g, Fructus Foeniculi 210g, Fructus Ulmus preparatium 200g, Flos Caryophylli 140g, Fructus Piperis 170g, Cortex cynoglossi zeylanici radicis 120g, Fructus Piperis Longi 240g, Pericarpium Citri Reticulatae 220g, Rhizoma Et Radix Notopterygii 260g, Radix Aucklandiae 320g, Herba Cayatiae Japonicae 300g, Lignum Santali Albi 220g, Semen Litchi 240g, Herba Potentillae Chinensis 250g, FLOS MUME 220g, Bulbus Allii Macrostemonis 280g, Plantula cucurbitae moschatae 230g, Herba Aristolochiae 330g, Radix Aristolochiae 190g, Radix Et Rhizoma Nardostachyos 260g, Calyx Kaki 290g, Rhizoma et radix valerianae 220g, Massa Medicata Fermentata 200g, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 260g, Fructus Oryzae Germinatus 250g, Rhizoma Polliae Japonicae 290g, Semen Raphani 240g, Resina Ferulae 280g, Semen Arecae 160g, Ramulus et Folium Phyllodii Pulchelli 320g, Radix Astragali 330g, Rhizoma Atractylodis Macrocephalae 200g, Folium Lagerstroemiae Indicae 210g, Rhizoma Dioscoreae 230g, from thing mouth grass 10g, Semen Lablab Album 140g, Radix Rhodiolae 330g and Fructus Hippophae 300g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 95%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 500 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.04 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 3 capsule

The manufacturing process of oral capsule of the present invention is: get Corm Brassicae caulorapae 190g, Pyrrosia hastata (Thunb.) Ching 230g, Rhizoma Zingiberis 320g, hyoscyami 330g, Cortex Cinnamomi 240g, milk 180g, Fructus Foeniculi 160g, Fructus Ulmus preparatium 90g, Flos Caryophylli 220g, Fructus Piperis 110g, Cortex cynoglossi zeylanici radicis 170g, Fructus Piperis Longi 220g, Pericarpium Citri Reticulatae 190g, Rhizoma Et Radix Notopterygii 260g, Radix Aucklandiae 320g, Herba Cayatiae Japonicae 250g, Lignum Santali Albi 220g, Semen Litchi 230g, Herba Potentillae Chinensis 190g, FLOS MUME 240g, Bulbus Allii Macrostemonis 320g, Plantula cucurbitae moschatae 240g, Herba Aristolochiae 330g, Radix Aristolochiae 190g, Radix Et Rhizoma Nardostachyos 300g, Calyx Kaki 260g, Rhizoma et radix valerianae 240g, Massa Medicata Fermentata 220g, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 260g, Fructus Oryzae Germinatus 250g, Rhizoma Polliae Japonicae 280g, Semen Raphani 250g, Resina Ferulae 230g, Semen Arecae 270g, Ramulus et Folium Phyllodii Pulchelli 330g, Radix Astragali 300g, Rhizoma Atractylodis Macrocephalae 150g, Folium Lagerstroemiae Indicae 130g, Rhizoma Dioscoreae 170g, from thing mouth grass 20g, Semen Lablab Album 250g, Radix Rhodiolae 300g and Fructus Hippophae 260g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.3:0.4, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Acute toxicity testing:

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 2 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: the injectable powder of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: the 308 routine spleen-stomach deficiency-cold Peptic Ulcers of my institute Digestive System Department patient during getting in March ,-2012 in February, 2010, peptic ulcer diagnostic criteria that all cases all meets " practical internal medicine ", through methods such as Abdominal B type ultrasonography, gastroscope and pathologic findings, and make a definite diagnosis in conjunction with common clinical manifestation, man 198 people, female 110 people; 30 ~ 49 years old age, year mean age (41.3 ± 7.5); The course of disease 1 month ~ 13 years.By being admitted to hospital, sequencing is divided into medication therapy groups and western medicine group at random, medication therapy groups 231 people, male 152 people, female 79 people, and wherein, medication therapy groups is divided into three components not to be injectable powder treatment group, tablet in treatment group and capsule treatment group, often organizes 77 people; Western medicine group 77 people, male 46 people, female 31 people.Often organize patient to compare in age, sex, the course of disease and diseased region etc., the equal not statistically significant of difference (P > 0.05), has comparability.

The clinical manifestation of 308 routine spleen-stomach deficiency-cold Peptic Ulcers: 1. symptom: the (1) position of pain and character: Most patients has epigastrium pain, duodenal ulcer pain can be to the right under xiphoid-process, under gastric ulcer under body of stomach and cardia shows as left front breast or left Upper abdominal pain, stomachache indistinctly, endlessly continuous, cold type of pain is uncomfortable, likes warm cream and presses, pain of empty stomach very, obtains food and then delays.Rear wall canker sores can radiate to back.Characteristic of pain in dull pain or can burn sample, spasm sample, hungry sample pain.

(2) rhythmicity pain: duodenal ulcer pain generally 2 ~ 4 hours after the meal occur, in pain, feed, alleviation rule, often with hypnalgia; Gastric ulcer pain is many at 1 hours after the meal, and in feed, pain, alleviation rule, fatigue or eat cold or panic attacks or increase the weight of, general vomiting watery fluid, lack of appetite, spiritlessness and weakness, hands and feet being not warm after suffering from cold, large loose stool is thin, pale tongue with white fur, deficient and weak pulse.

(3) the chronic course of disease, periodical attack: medical history can reach several years or the more than ten years, outbreak, in periodically, replaces with the catabasis, with Qiu Mo and the spring multiple at the beginning.Can with indigestion symptoms such as acid regurgitation, belch, Abdeminal pains.But along with anti-H. pyloriuniversal and the therapeutic scheme for the treatment of perfect, the case of recurrent exerbation greatly reduces.

2. sign: common positive sign is epigastrium local tenderness, and anemia appears in small number of patients, some patients can become thin or body constitution thin and weak.

Diagnostic criteria:

(1) epigastrium pain is the cardinal symptom of primary disease, but also many without pain person.The pain of stomach or duodenal back mural ulcer, particularly penetrating ulcer can be radiated to back.

(2) acid regurgitation, belch, heartburn, the indigestion symptom such as Abdeminal pain, Nausea and vomiting, loss of appetite can be had, but these symptoms all lack specificity, during bleeding, can occur hematemesis and (or) melena.

(3) active stage ulcers has the light tenderness of epigastrium limitation more, the slightly biased right side of duodenal ulcer pressure pain point.Small number of patients can have anemia because of chronic blood loss or malnutrition.Concurrent pyloric obstruction person, can have gastric peristalsis to involve succussion splash.Limitation or diffuse peritonitis performance can be had during perforated ulcer.

(4) gastroscopy: directly can observe Grastiodudenal mucosa and get mucosa specimen and do pathology and helicobacter pylori inspection, high to the accuracy of the diagnosis of peptic ulcer and benign ulcer, malignant ulcer Differential Diagnosis.Endoscopy should record the position, size, number etc. of ulcer.Under scope, ulcer can be divided into active stage (A1, A2), healing stage (H1, H2) and cicatricial phase (S1, S2).Gastric ulcer must when ulcer edge multiple spot specimen send pathologic finding Peptic ulcer bleeding, the visible active hemorrhage of emergency endoscopy or sign hemorrhage in the recent period; When merging pyloric obstruction, gastric has retention thing.

(5) x-ray barium meal examination: adopt air-saturated soils more.The x-ray sign of peptic ulcer has directly and indirect two kinds, and the former is the reliable basis of diagnosis primary disease, the latter's limited specificity.Niche is the direct sign of ulcer; Monospasm, excitation, bulb deformity and local tenderness etc. are the indirect signs of ulcer.

(6) helicobacter pylori detects: during endoscopy, gets antral gastric mucosa specimen do helicobacter pylori detection at distance pylorus 3 ~ 5cm place.After Anti-Helicobacter Pylori Therapy, to previously having repeatedly ulcer recurrence or have hemorrhage history person, helicobacter pylori should be checked and whether eradicate, now can select to do the inspection of 14C or 13C urea breath test.

(7), when suspecting gastrinoma, serum gastrin determination and gastric analysis is made; During upper gastrointestinal hemorrhage, do occult blood test.

Therapeutic Method:

In medication therapy groups:

Injectable powder treatment group: the injectable powder using the embodiment of the present invention 1 to prepare, gets 0.4g water by obtained injectable powder and fully dissolves, be mixed with 0.1g/ml, then be added in the sodium chloride injection of 500ml, then intravenous drip.Concentration is 1.0mg/ml, 1 time on the one, and the time of once instiling is 3 hours, within every 30 days, is a course for the treatment of;

Tablet in treatment group: take the embodiment of the present invention 2 prepare tablet, every day 3 times, one time 4, within every 30 days, be a course for the treatment of;

Capsule treatment group: use the embodiment of the present invention 3 prepare capsule, every day 3 times, one time 2, within every 30 days, be a course for the treatment of.

Western medicine group: the injection omeprazole sodium injection that intravenous drip configures, injection omeprazole sodium is dissolved in 100 milliliter of 5% glucose injection, dissolves posterior vein and instil 30 minutes, intravenous drip every day 40mg, once a day, within every 30 days, be a course for the treatment of.

Efficacy assessment standard: use the efficacy assessment standard to peptic ulcer in " medicine Drugs in Therapy peptic ulcer guideline of clinical investigations ".Cure: ulcer place and around inflammation place all disappear, x-ray canel barium meal contrast examination or gastroscopy normal.Effective: ulcer place disappears, but part affected part still has inflammation, and x-ray canel barium meal contrast examination or gastroscopy are significantly improved.Effective: ulcer place area reduces and is greater than 50%, x-ray canel barium meal contrast examination or gastroscopy are effectively.Invalid: symptom is without any improvement, x-ray canel barium meal contrast examination or gastroscopy unchanged.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy spleen-stomach deficiency-cold peptic ulcer of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy spleen-stomach deficiency-cold peptic ulcer of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Table 2 Four composition do not treat after 4 courses for the treatment of cure, effective and efficiently individual quantity and time comparative example (%)

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Treatment group is cured simultaneously, 230 examples of effective and efficiently individual quantity and western medicine group is cured, effective and effective 64 routine follow-up of patients 1 year half, result is added up, in injectable powder treatment group 76 example, healing 27 example and effective 30 examples are all without recurrence, 1 case relapsed in effective 19 examples, and relapse rate is 1.3%; In tablet in treatment group 77 example, healing 28 example and effective 31 examples are all without recurrence, 1 case relapsed in effective 18 examples, and relapse rate is 1.3%; Cure 27 examples in capsule treatment group 77 example without recurrence, 1 case relapsed in effective 30 examples, 1 case relapsed in effective 20 examples, relapse rate is 2.6%; Western medicine group is cured, effective and efficiently individual quantity 64 example, recurs 5 examples, recurs 9 examples in effective 22 routine patients, recur 13 examples, relapse rate 42.1% in effective 28 examples in 14 routine patients of healing; Above-mentioned recurrence refer to patient outcomes reach healing, effective or effectively after, in 1 year half of following up a case by regular visits to, obviously there is the symptom before treatment.

Model case: Wang, women, 48 years old, because having a stomachache indistinctly, endlessly continuous, pain of empty stomach very half a year, occasional is because of tired or eat cold or panic attacks or increase the weight of after suffering from cold, through Abdominal B type ultrasonography, the method such as gastroscope and pathologic finding, and make a definite diagnosis in conjunction with common sympton and the performance of levying body, tentatively be judged as peptic ulcer, in addition, also can with spiritlessness and weakness, hands and feet being not warm, large loose stool is thin, pale tongue with white fur, deficient and weak pulse and can with acid regurgitation, belch, the indigestion symptoms such as Abdeminal pain, then hope according to the traditional Chinese medical science, hear, ask, cut and be diagnosed as spleen-stomach deficiency-cold peptic ulcer further.Take the tablet of pharmaceutical preparation embodiment 2 of the present invention, every day 3 times, each 4, treat and substantially cure 2 courses for the treatment of, continue healing in 1 month of taking medicine, follow up a case by regular visits to and do not recur for 1 year half.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the pharmaceutical preparation of spleen-stomach deficiency-cold peptic ulcer for one kind, it is characterized in that, comprise following raw medicinal material: Corm Brassicae caulorapae, Pyrrosia hastata (Thunb.) Ching, Rhizoma Zingiberis, hyoscyami, Cortex Cinnamomi, milk, Fructus Foeniculi, Fructus Ulmus preparatium, Flos Caryophylli, Fructus Piperis, Cortex cynoglossi zeylanici radicis, Fructus Piperis Longi, Pericarpium Citri Reticulatae, Rhizoma Et Radix Notopterygii, the Radix Aucklandiae, Herba Cayatiae Japonicae, Lignum Santali Albi, Semen Litchi, Herba Potentillae Chinensis, FLOS MUME, Bulbus Allii Macrostemonis, the Plantula cucurbitae moschatae, Herba Aristolochiae, Radix Aristolochiae, Radix Et Rhizoma Nardostachyos, Calyx Kaki, Rhizoma et radix valerianae, Massa Medicata Fermentata, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd., Fructus Oryzae Germinatus, Rhizoma Polliae Japonicae, Semen Raphani, Resina Ferulae, Semen Arecae, Ramulus et Folium Phyllodii Pulchelli, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Folium Lagerstroemiae Indicae, Rhizoma Dioscoreae, from thing mouth grass, Semen Lablab Album, Radix Rhodiolae and Fructus Hippophae.

2. the pharmaceutical preparation for the treatment of spleen-stomach deficiency-cold peptic ulcer according to claim 1, is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 14 ~ 32 parts, Pyrrosia hastata (Thunb.) Ching 10 ~ 27 parts, Rhizoma Zingiberis 16 ~ 34 parts, hyoscyami 17 ~ 35 parts, Cortex Cinnamomi 10 ~ 28 parts, milk 12 ~ 32 parts, Fructus Foeniculi 10 ~ 25 parts, Fructus Ulmus preparatium 7 ~ 22 parts, Flos Caryophylli 9 ~ 24 parts, 10 ~ 21 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 10 ~ 24 parts, Fructus Piperis Longi 16 ~ 28 parts, Pericarpium Citri Reticulatae 15 ~ 27 parts, Rhizoma Et Radix Notopterygii 16 ~ 29 parts, the Radix Aucklandiae 17 ~ 34 parts, Herba Cayatiae Japonicae 16 ~ 32 parts, 18 ~ 27 parts, Lignum Santali Albi, Semen Litchi 14 ~ 26 parts, Herba Potentillae Chinensis 18 ~ 32 parts, FLOS MUME 15 ~ 26 parts, Bulbus Allii Macrostemonis 18 ~ 34 parts, the Plantula cucurbitae moschatae 16 ~ 29 parts, Herba Aristolochiae 15 ~ 35 parts, Radix Aristolochiae 16 ~ 31 parts, Radix Et Rhizoma Nardostachyos 18 ~ 32 parts, Calyx Kaki 18 ~ 31 parts, Rhizoma et radix valerianae 13 ~ 25 parts, Massa Medicata Fermentata 11 ~ 24 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 32 parts, Fructus Oryzae Germinatus 17 ~ 29 parts, Rhizoma Polliae Japonicae 14 ~ 32 parts, Semen Raphani 11 ~ 27 parts, Resina Ferulae 13 ~ 32 parts, Semen Arecae 10 ~ 32 parts, Ramulus et Folium Phyllodii Pulchelli 14 ~ 35 parts, the Radix Astragali 19 ~ 35 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Folium Lagerstroemiae Indicae 12 ~ 23 parts, Rhizoma Dioscoreae 17 ~ 27 parts, from thing mouth grass 1 ~ 2 part, Semen Lablab Album 8 ~ 31 parts, Radix Rhodiolae 19 ~ 34 parts and Fructus Hippophae 17 ~ 32 parts.

3. the pharmaceutical preparation for the treatment of spleen-stomach deficiency-cold peptic ulcer according to claim 1 and 2, is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 16 ~ 30 parts, Pyrrosia hastata (Thunb.) Ching 12 ~ 25 parts, Rhizoma Zingiberis 18 ~ 32 parts, hyoscyami 19 ~ 30 parts, Cortex Cinnamomi 18 ~ 26 parts, milk 17 ~ 29 parts, Fructus Foeniculi 14 ~ 24 parts, Fructus Ulmus preparatium 8 ~ 20 parts, Flos Caryophylli 11 ~ 22 parts, 14 ~ 20 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 13 ~ 21 parts, Fructus Piperis Longi 18 ~ 26 parts, Pericarpium Citri Reticulatae 19 ~ 25 parts, Rhizoma Et Radix Notopterygii 18 ~ 26 parts, the Radix Aucklandiae 19 ~ 32 parts, Herba Cayatiae Japonicae 17 ~ 26 parts, 19 ~ 24 parts, Lignum Santali Albi, Semen Litchi 15 ~ 25 parts, Herba Potentillae Chinensis 18 ~ 26 parts, FLOS MUME 16 ~ 24 parts, Bulbus Allii Macrostemonis 19 ~ 32 parts, the Plantula cucurbitae moschatae 17 ~ 27 parts, Herba Aristolochiae 16 ~ 33 parts, Radix Aristolochiae 17 ~ 30 parts, Radix Et Rhizoma Nardostachyos 19 ~ 31 parts, Calyx Kaki 19 ~ 30 parts, Rhizoma et radix valerianae 15 ~ 24 parts, Massa Medicata Fermentata 13 ~ 22 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 18 ~ 22 parts, Fructus Oryzae Germinatus 18 ~ 26 parts, Rhizoma Polliae Japonicae 15 ~ 30 parts, Semen Raphani 13 ~ 25 parts, Resina Ferulae 15 ~ 30 parts, Semen Arecae 15 ~ 30 parts, Ramulus et Folium Phyllodii Pulchelli 15 ~ 32 parts, the Radix Astragali 20 ~ 32 parts, the Rhizoma Atractylodis Macrocephalae 13 ~ 20 parts, Folium Lagerstroemiae Indicae 14 ~ 22 parts, Rhizoma Dioscoreae 18 ~ 24 parts, from thing mouth grass 1 ~ 2 part, Semen Lablab Album 9 ~ 26 parts, Radix Rhodiolae 22 ~ 33 parts and Fructus Hippophae 18 ~ 30 parts.

4. the pharmaceutical preparation of the treatment spleen-stomach deficiency-cold peptic ulcer according to any one of claim 1-3, it is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 25 parts, Pyrrosia hastata (Thunb.) Ching 22 parts, Rhizoma Zingiberis 26 parts, hyoscyami 20 parts, Cortex Cinnamomi 19 parts, milk 24 parts, Fructus Foeniculi 15 parts, Fructus Ulmus preparatium 18 parts, Flos Caryophylli 17 parts, 16 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 19 parts, Fructus Piperis Longi 22 parts, Pericarpium Citri Reticulatae 24 parts, Rhizoma Et Radix Notopterygii 25 parts, the Radix Aucklandiae 27 parts, Herba Cayatiae Japonicae 24 parts, 22 parts, Lignum Santali Albi, Semen Litchi 19 parts, Herba Potentillae Chinensis 23 parts, FLOS MUME 21 parts, Bulbus Allii Macrostemonis 29 parts, the Plantula cucurbitae moschatae 25 parts, Herba Aristolochiae 32 parts, Radix Aristolochiae 18 parts, Radix Et Rhizoma Nardostachyos 24 parts, Calyx Kaki 26 parts, Rhizoma et radix valerianae 22 parts, Massa Medicata Fermentata 14 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 21 parts, Fructus Oryzae Germinatus 24 parts, Rhizoma Polliae Japonicae 26 parts, Semen Raphani 23 parts, Resina Ferulae 19 parts, Semen Arecae 20 parts, Ramulus et Folium Phyllodii Pulchelli 22 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Folium Lagerstroemiae Indicae 20 parts, Rhizoma Dioscoreae 23 parts, from thing mouth grass 2 parts, Semen Lablab Album 25 parts, Radix Rhodiolae 27 parts and Fructus Hippophae 26 parts.

5. the pharmaceutical preparation of the treatment spleen-stomach deficiency-cold peptic ulcer according to any one of claim 1-4, it is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 28 parts, Pyrrosia hastata (Thunb.) Ching 18 parts, Rhizoma Zingiberis 24 parts, hyoscyami 32 parts, Cortex Cinnamomi 23 parts, milk 28 parts, Fructus Foeniculi 21 parts, Fructus Ulmus preparatium 20 parts, Flos Caryophylli 14 parts, 17 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 12 parts, Fructus Piperis Longi 24 parts, Pericarpium Citri Reticulatae 22 parts, Rhizoma Et Radix Notopterygii 26 parts, the Radix Aucklandiae 32 parts, Herba Cayatiae Japonicae 30 parts, 22 parts, Lignum Santali Albi, Semen Litchi 24 parts, Herba Potentillae Chinensis 25 parts, FLOS MUME 22 parts, Bulbus Allii Macrostemonis 28 parts, the Plantula cucurbitae moschatae 23 parts, Herba Aristolochiae 33 parts, Radix Aristolochiae 19 parts, Radix Et Rhizoma Nardostachyos 26 parts, Calyx Kaki 29 parts, Rhizoma et radix valerianae 22 parts, Massa Medicata Fermentata 20 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 26 parts, Fructus Oryzae Germinatus 25 parts, Rhizoma Polliae Japonicae 29 parts, Semen Raphani 24 parts, Resina Ferulae 28 parts, Semen Arecae 16 parts, Ramulus et Folium Phyllodii Pulchelli 32 parts, the Radix Astragali 33 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Folium Lagerstroemiae Indicae 21 parts, Rhizoma Dioscoreae 23 parts, from thing mouth grass 1 part, Semen Lablab Album 14 parts, Radix Rhodiolae 33 parts and Fructus Hippophae 30 parts.

6. the pharmaceutical preparation of the treatment spleen-stomach deficiency-cold peptic ulcer according to any one of claim 1-5, it is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Corm Brassicae caulorapae 19 parts, Pyrrosia hastata (Thunb.) Ching 23 parts, Rhizoma Zingiberis 32 parts, hyoscyami 33 parts, Cortex Cinnamomi 24 parts, milk 18 parts, Fructus Foeniculi 16 parts, Fructus Ulmus preparatium 9 parts, Flos Caryophylli 22 parts, 11 parts, Fructus Piperis, Cortex cynoglossi zeylanici radicis 17 parts, Fructus Piperis Longi 22 parts, Pericarpium Citri Reticulatae 19 parts, Rhizoma Et Radix Notopterygii 26 parts, the Radix Aucklandiae 32 parts, Herba Cayatiae Japonicae 25 parts, 22 parts, Lignum Santali Albi, Semen Litchi 23 parts, Herba Potentillae Chinensis 19 parts, FLOS MUME 24 parts, Bulbus Allii Macrostemonis 32 parts, the Plantula cucurbitae moschatae 24 parts, Herba Aristolochiae 33 parts, Radix Aristolochiae 19 parts, Radix Et Rhizoma Nardostachyos 30 parts, Calyx Kaki 26 parts, Rhizoma et radix valerianae 24 parts, Massa Medicata Fermentata 22 parts, Chaenomeles lagenaria (Loisel.) Koidz. Var. Cathayensis (Hemsl.) Rehd. 26 parts, Fructus Oryzae Germinatus 25 parts, Rhizoma Polliae Japonicae 28 parts, Semen Raphani 25 parts, Resina Ferulae 23 parts, Semen Arecae 27 parts, Ramulus et Folium Phyllodii Pulchelli 33 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Folium Lagerstroemiae Indicae 13 parts, Rhizoma Dioscoreae 17 parts, from thing mouth grass 2 parts, Semen Lablab Album 25 parts, Radix Rhodiolae 30 parts and Fructus Hippophae 26 parts.

7. the pharmaceutical preparation of the treatment spleen-stomach deficiency-cold peptic ulcer according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

8. the pharmaceutical preparation of the treatment spleen-stomach deficiency-cold peptic ulcer according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

9. the pharmaceutical preparation of the treatment spleen-stomach deficiency-cold peptic ulcer according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.