CN105998297B - A kind of Chinese medicine composition for relaxing bowel and preparation method thereof - Google Patents
A kind of Chinese medicine composition for relaxing bowel and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of Chinese medicine composition for relaxing bowel and preparation method thereof, said composition includes 2~6 parts of 6~12 parts of semen armeniacae amarae, 6~12 parts of peach kernel, 3~8 parts of fructus cannabis, 3~8 parts of SEMEN PINI KORAIENSIS, 3~8 parts of brush-cherry seed and orange peel, can also further include 2~5 parts of 4~7 parts of lotus seeds, 3~6 parts of lily, 3~6 parts of matrimony vine and ginger.Chinese medicine composition of the present invention has functions that to relax bowel, and easily absorbs, and bioavilability is high, can also be made into the various formulations such as granule, capsule, oral liquid and pill, evident in efficacy, definite, can be applicable.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for relaxing bowel and preparation method thereof.
Background technology
Constipation refers to obstructed constipation, defecation cycle stretch-out, or is intended to defecate and a kind of involved and abstruse not smooth clinical symptoms.It is long
The constipation of phase can bring huge pain to patient, and the mental burden of making patients increases anxiety and tense mood, and in human body
Environment, internal system have a certain impact, and are with the passing of time likely to induce or aggravate other diseases, influence the life matter of patient
Amount.
The traditional Chinese medical science thinks that constipation is more by heat accumulating in the large intestine, or the stagnation of the circulation of vital energy or cold solidifying, or yang blood and qi virtual loss, causes large intestine conduction function
It is not normal to form.Warm to have no right and old weakness constipation is more by Kidney-Yin loss, cloudy evil condensation, or yin deficiency blood is dry, and big intestinal juice is withered, nothing
Lixing boat, belongs to asthenic symptoms more.
At present, in the traditional Chinese medical science, old weakness constipation is generally divided into (1) qi-deficiency type：Symptoms include defecate not stiff, discharge is difficult, empty
Seat is exerted and is earned, sweating shortness of breath, weak after an action of the bowels, and colourless god is tired, the white weak pulse of tongue；(2) blood-deficiency type：Symptoms include just do, have a dizzy spell, complexion without
China, palpitation, lip and nail color is light, the white weak pulse of tongue；(3) YIN-deficiency type：Symptoms include just as sheep dung, body are become thin, dizziness and tinnitus is vexed few
Sleep, hectic fever night sweat, soreness and weakness of waist and knees, the red arteries and veins of tongue is thin；(4) deficiency of yang type：Symptoms include stool discharge is difficult, clear abundant urine, pale white complexion, four
Limb is not warm, crymodynia in abdomen, pale tongue with white fur, deep thready pulse.
Constipation for children is generally divided into：(1) accumulated heat constipation：Present food variety is various, and pediatric diet is improper, and overfeeding is pungent small
Snacks, fragrant dry dilated food or food are excessively fine, cause dryness-heat stagnating in the interior, and internal organs conduction is not normal, so as to cause constipation；Symptoms include
Be hard and dry, hard, difficult defecation, abdominal distension stomachache, do not feel like eating, with tired urgency halitosis, feverishness in palms and soles, lip extra dry red wine, urine is yellow
It is few；Control suitable heat-clearing treatment for relieving indigestion and constipation.(2) weak constipation：It is many that large intestine transmission is powerless or consumption hinders body fluid after being ill, constipation because congenital insufficiency of the spleen,
It is powerless submitting and cause；Symptoms include frequent constipation, under difficulty in defecation, or rear dilute, sallow complexion is first done, abdominal distension fart, lassitude hypodynamia,
Tongue nature is light, and tongue fur is white, and arteries and veins delays；Due to difficult defecation, part children can lose the appetite, sleep disorder, or due to just when use
Power too, causes anal fissure or hemorrhoid, therefore controls preferably to nourish and relax bowel.
The old weakness constipation of chinese herbal compound treatment and constipation for children method are various, and dialectical to treat, treating a disease by looking into both its root cause and symptoms, curative effect shows
Write.Wuren pills (tcm prescription name), is recorded at first《Young man Tibetan side》, also known as intestines wuren pills is grown, it is that " seminal fluid is withered for treatment according to load
Exhaust, large intestine it is secret it is puckery, conduct it is difficult " effect prescription.Peach kernel, almond, SEMEN PINI KORAIENSIS, the seed of Oriental arborvitae, brush-cherry seed and dried orange peel are ground original side
Powder, such as making pellets by mixing medical powder with honey, Phoenix Tree Seed are big.30~50 balls are often taken, warm water takes.It is reproduced in again afterwards《The physicians from a family for generations obtain efficacious prescriptions》, cure mainly Tianjin withered
Intestinal dryness is demonstrate,proved；It is hard and dry, involved and abstruse difficulty goes out, and old or postpartum blood deficiency and constipation.Ancient prescription wuren pills collect rich grease-contained kernel in
One side, the dried orange peel of compatibility regulating qi-flowing for activating stagnancy, mild laxation is harmonious with promoting the circulation of qi, the effect of main moisturize laxation, but its, heart weak for the elderly
The symptoms such as tired, insomnia easily recur after not having good opsonic action, and drug withdrawal.Meanwhile, ancient prescription wuren pills is with five Renhe dried orange peels
Milling pill, on the one hand directly taking active compound is unfavorable for absorption of human body, and bioavilability is low；On the other hand, its type of preparation list
One, children or dysphagia person are not appropriate for taking pill, and influence patient's takes wish.In addition, in mixed nuts rich in linoleic acid,
The unrighted acids such as leukotrienes, unrighted acid has multiple unsaturated double-bonds, so being oxidized easily, fatty acid occurs
Lose, cause the shelf-life of wuren pills short, be unfavorable for popularization and application.
To sum up, it is necessary to be improved and optimize on the basis of ancient prescription wuren pills, it is raw to overcome its conditioning effect not good enough
Thing availability is low, easily recurrence, the deficiency such as oxidizable, unstable, for old weakness constipation patient and constipation for children provide a kind of profit
Intestines defaecation, Chinese medicine composition evident in efficacy.
The content of the invention
In order to solve problems of the prior art, (conditioning effect of ancient prescription wuren pills is not good enough, and bioavilability is low, medicine
Effect is not good enough, oxidizable, unstable etc.), the invention provides a kind of Chinese medicine composition for relaxing bowel, Chinese medicine composition of the present invention
Easily absorb, bioavilability is good, not only has functions that to relax bowel, moreover it is possible to which improvement is had a sleepless night, vexed gas is hot-tempered etc., and system is steady
It is fixed, long shelf-life.
To achieve these goals, technical scheme is as follows：
A kind of Chinese medicine composition for relaxing bowel, it is characterised in that the preparing raw material including following weight portion：Semen armeniacae amarae 6
2~6 parts of~12 parts, 6~12 parts of peach kernel, 3~8 parts of fructus cannabis, 3~8 parts of SEMEN PINI KORAIENSIS, 3~8 parts of brush-cherry seed and orange peel.
Preferably, the described Chinese medicine composition for relaxing bowel includes the preparing raw material of following weight portion：8 parts of semen armeniacae amarae,
4 parts of 7 parts of peach kernel, 6 parts of fructus cannabis, 6 parts of SEMEN PINI KORAIENSIS, 6 parts of brush-cherry seed and orange peel.
Further, the Chinese medicine composition also includes 4~7 parts of lotus seeds, 3~6 parts of lily, 3~6 parts of matrimony vine and ginger 2
~5 parts.
Further, the Chinese medicine composition also includes 3 parts of 6 parts of lotus seeds, 5 parts of lily, 5 parts of matrimony vine and ginger.
Further, the Chinese medicine composition is granule, capsule, oral liquid and pill.
Accordingly, present invention also offers the preparation method of the above-mentioned Chinese medicine composition for relaxing bowel, specifically include with
Lower step：
The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10 mesh sieves, adds
4~6 times of water of medicinal material amount, soak 1.5~2h, and filtering is subsequently added into 6~9 times of ethanol of medicinal material amount, are 30 in ultrasonic frequency
~40kHz, power is 200~300W, and to be extracted at 40~50 DEG C 1~2 time, 30~40min, filtering, close Extracting temperature every time
And filtrate, filter vacuum is concentrated under reduced pressure into the 1/4~1/3 of original volume, and concentrate A is obtained；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 3~6 times of water of medicinal material amount, 1~2h of refluxing extraction, mistake
Filter, filter vacuum is concentrated under reduced pressure into the 1/4~1/3 of original volume, and orange peel concentrate is obtained；
The mixing of S3, the lotus seeds for taking formula ratio, lily and matrimony vine, crushed 10 mesh sieves, added 4~7 times of water of medicinal material amount, returned
Stream extracts 2~3h, and filtering, filter vacuum is concentrated under reduced pressure into the 1/4~1/3 of original volume, and concentrate B is obtained；
S4, the ginger for taking formula ratio, section add 2~4 times of ethanol of medicinal material amount, 1~2h of refluxing extraction, filtering, filtrate
Vacuum-concentrcted is obtained ginger concentrate to the 1/4~1/3 of original volume；
S5, by the concentrate A, orange peel concentrate, concentrate B and ginger concentrate mix, mixed liquor is in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.10~1.20 is concentrated into, drying under reduced pressure is crushed, and the Chinese traditional medicine composition for relaxing bowel is obtained
Thing.
Further, the concentration of volume percent of ethanol is 90~95% in the step S1.
Further, the concentration of volume percent of ethanol is 60~70% in the step S4.
In the inventive solutions, semen armeniacae amarae is rosaceous plant apricot, wild apricot, ansu apricot, the drying and ripening of prunus mandshuricaKoehne
Benevolence, detoxification, peeling；Peach kernel is the dry mature seed of rosaceous plant peach or mountain peach.Fructus cannabis is moraceae plants hemp
The dry mature kernal of (Cannabis sativa L.)；SEMEN PINI KORAIENSIS is Huashan pine, Korean pine, the masson pine in Pinaceae pine genus plant
Dry mature kernal；Brush-cherry seed is the dry mature seed of strongly fragrant Lee of rosaceous plant, Ou Li, flowering plum and stalk almond long etc..
Orange peel is the dry mature skin of rutaceae orange (Citrus reticulataBlanco) and its variety.Lotus seeds are
The dry mature seed of nymphaeaceae plant lotus (Nelumbo nucifera Gaertn.)；Lily is liliaceous plant lily, thin
Leaf lily, Lilium longiflorum and its belong to various plants bulb together dry scale leaf；Matrimony vine is dried to for plant of Solanaceae lycium barbarum
Ripe fruit；Ginger is the new fresh quench stem of Zingiber herbaceos perennial ginger (Zingiber officinale Roscoe).
The semen armeniacae amarae for moistening greasiness with matter is monarch drug in a prescription, to grow intestinal dryness, and drops lung qi, and the duty of profit large intestine conduction；It is with peach kernel
Ministerial drug, takes its moisturize laxation, to help the power of almond；Being lubricated fructus cannabis, moistening lung controls dry more, it is empty secret with controlling；Brush-cherry seed matter lubricant nature
Drop, lubricates enteron aisle, and it is scorching specially to control stomach, constipation；SEMEN PINI KORAIENSIS moisturizing viscera, controls empty secret, is altogether adjutant；Again with orange peel qi-regulating row
It is stagnant, enable gas row then large intestine transporting.
Prescription is further compounded with lotus seeds, lily, matrimony vine and ginger, lotus seeds relieving restlessness that clears away heart-fire, mental-tranquilization, lily QI invigorating are grown
Cloudy, clear waste heat, matrimony vine is nourishing liver and kidney, benefiting shrewd head, is altogether adjutant；Ginger warming spleen and stomach for dispelling cold, Appetizing spleen-tonifying, to close medicine, all medicines
With, play altogether relax bowel, feel at ease to allay excitement, the effect of reinvigoration.
In addition, inventor has been unexpectedly discovered that the addition of lotus seeds, lily, matrimony vine and ginger, the not only work(to relaxing bowel
Effect has a booster action, and can nurse one's health the situations such as vexed, gas is hot-tempered, weak, improves the health care of sleep quality, also effectively increases bitter apricot
The stability of benevolence, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and Semen Pruni extract so that present composition stable system, shelf-life
It is long.
By the Chinese medicine composition relaxed bowel obtained in preparation method of the present invention, compared with ancient prescription wuren pills, its curative effect
It is more notable, and recurrence is difficult, on the one hand reflecting preparation method of the present invention can effectively extract the active component of bulk drug, reach
The purpose of the old weakness constipation for the treatment of, on the other hand embodies Chinese medicine composition of the present invention and is easier to be absorbed by the body, biological profit
Expenditure is high；Meanwhile, Chinese medicine composition of the present invention can also be made into the various formulations such as granule, capsule, oral liquid and pill, full
The demand of sufficient people.
Therefore, compared with prior art, advantage of the invention is that：
(1) Chinese medicine composition that the present invention relaxes bowel easily absorbs, and bioavilability is high, not only with the work(for relaxing bowel
Effect, moreover it is possible to nurse one's health the situations such as vexed, gas is hot-tempered, weak, improve the health care of sleep quality, curative effect is controlled to old weakness constipation and constipation for children
Fruit is notable, definite, and stable system, long shelf-life, can also be made into the various formulations such as granule, oral liquid and pill, has
Good application prospect.
(2) condition of the Chinese medicine composition preparation method that the present invention relaxes bowel is controllable, process stabilizing, can industrial metaplasia
Produce, be conducive to popularization and application.
Specific embodiment
The present invention is further described below by way of specific embodiment, the present invention is not limited only to following examples.In this hair
In bright scope or not departing from present disclosure, spirit and scope, the change that is carried out to the present invention, combine or replace
Change, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Chinese medicine composition and its preparation that embodiment 1, the present invention relax bowel
Formula：Semen armeniacae amarae 6kg, peach kernel 6kg, fructus cannabis 3kg, SEMEN PINI KORAIENSIS 3kg, brush-cherry seed 3kg and orange peel 2kg.
Preparation method：The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10
Mesh sieve, adds 84kg water, soaks 1.5h, and filtering is subsequently added into the ethanol that 126kg concentration of volume percent is 90%, in ultrasound
Wave frequency rate, is 30kHz, and power is 200W, and to be extracted 1 time at 40 DEG C, each 40min is filtered, merging filtrate, filtrate Extracting temperature
Vacuum-concentrcted is obtained concentrate A to the 1/4 of original volume；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 6kg water, refluxing extraction 1h, filtering, filter vacuum to subtract
Pressure is concentrated into the 1/4 of original volume, and orange peel concentrate is obtained；
S3, by the concentrate A, orange peel concentrate mix, mixed liquor is in vacuum-concentrcted to relative density at 60 DEG C
It is 1.10 medicinal extract, drying under reduced pressure crushed 80 mesh sieves, the Chinese medicine composition for relaxing bowel is obtained.
Separately taking honey carries out refined honey, and the refined honey for obtaining compares 1 with above-mentioned Chinese medicine composition medicinal powder according to weight:1 mixes, pill
Block, rubs ball bar with the hands, and pill grain, the weight 0.2g per ball is obtained the honeyed bolus of the Chinese medicine composition that the present invention relaxes bowel.
Chinese medicine composition and its preparation that embodiment 2, the present invention relax bowel
Formula：Semen armeniacae amarae 12kg, peach kernel 12kg, fructus cannabis 8kg, SEMEN PINI KORAIENSIS 8kg, brush-cherry seed 8kg and orange peel 6kg.
Preparation method：The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10
Mesh sieve, adds 288kg water, soaks 2h, and filtering is subsequently added into the ethanol that 432kg concentration of volume percent is 95%, in ultrasonic wave
Frequency is 40kHz, and power is 300W, and Extracting temperature at 50 DEG C to extract 2 times, and each 30min, filtering, merging filtrate, filtrate is true
Sky is concentrated under reduced pressure into the 1/3 of original volume, and concentrate A is obtained；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 36kg water, refluxing extraction 2h, filtering, filter vacuum to subtract
Pressure is concentrated into the 1/3 of original volume, and orange peel concentrate is obtained；
S3, by the concentrate A, orange peel concentrate mix, mixed liquor is in vacuum-concentrcted to relative density at 60 DEG C
It is 1.20 medicinal extract, drying under reduced pressure crushed 80 mesh sieves, the Chinese medicine composition for relaxing bowel is obtained.
Separately taking honey carries out refined honey, and the refined honey for obtaining compares 1 with above-mentioned Chinese medicine composition medicinal powder according to weight:1 mixes, pill
Block, rubs ball bar with the hands, and pill grain, the weight 0.2g per ball is obtained the honeyed bolus of the Chinese medicine composition that the present invention relaxes bowel.
Chinese medicine composition and its preparation that embodiment 3, the present invention relax bowel
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg and orange peel 4kg.
Preparation method：The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10
Mesh sieve, adds 165kg water, soaks 2h, and filtering is subsequently added into the ethanol that 231kg concentration of volume percent is 95%, in ultrasonic wave
Frequency is 35kHz, and power is 200W, and Extracting temperature at 45 DEG C to extract 2 times, and each 30min, filtering, merging filtrate, filtrate is true
Sky is concentrated under reduced pressure into the 1/3 of original volume, and concentrate A is obtained；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 20kg water, refluxing extraction 1h, filtering, filter vacuum to subtract
Pressure is concentrated into the 1/3 of original volume, and orange peel concentrate is obtained；
S3, by the concentrate A, orange peel concentrate mix, mixed liquor is in vacuum-concentrcted to relative density at 60 DEG C
It is 1.20 medicinal extract, drying under reduced pressure crushed 80 mesh sieves, the Chinese medicine composition for relaxing bowel is obtained.
Separately taking honey carries out refined honey, and the refined honey for obtaining compares 1 with above-mentioned Chinese medicine composition medicinal powder according to weight:1 mixes, pill
Block, rubs ball bar with the hands, and pill grain, the weight 0.2g per ball is obtained the honeyed bolus of the Chinese medicine composition that the present invention relaxes bowel.
Chinese medicine composition and its preparation that embodiment 4, the present invention relax bowel
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg and orange peel 4kg.
Preparation method is obtained the Chinese medicine composition for relaxing bowel with embodiment 3.
According to common process, above-mentioned Chinese medicine composition medicinal powder is taken, it is 65% ethanol to add 3 times of volume fractions of medicinal powder weight,
It is sufficiently stirred for, 24h is stood at room temperature, take supernatant, ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtains liquid；Described in
The water of 6 times of liquid weights is added to be diluted in liquid, filtering obtains final product the mouth of the Chinese medicine composition that the present invention relaxes bowel after standing
Take liquid.
Chinese medicine composition and its preparation that embodiment 5, the present invention relax bowel
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg and orange peel 4kg.
Preparation method is obtained the Chinese medicine composition for relaxing bowel with embodiment 3.
According to common process, above-mentioned Chinese medicine composition medicinal powder is mixed with auxiliary material, dry granulation, whole grain is obtained this hair
The granule of the bright Chinese medicine composition for relaxing bowel.
Chinese medicine composition and its preparation that embodiment 6, the present invention relax bowel
Formula：Semen armeniacae amarae 6kg, peach kernel 6kg, fructus cannabis 3kg, SEMEN PINI KORAIENSIS 3kg, brush-cherry seed 3kg and orange peel 2kg.
Preparation method is obtained the Chinese medicine composition for relaxing bowel with embodiment 2.
According to common process, above-mentioned Chinese medicine composition medicinal powder is mixed with auxiliary material, dry granulation, whole grain is obtained this hair
The granule of the bright Chinese medicine composition for relaxing bowel.
Chinese medicine composition and its preparation that embodiment 7, the present invention relax bowel
Formula：Semen armeniacae amarae 12kg, peach kernel 12kg, fructus cannabis 8kg, SEMEN PINI KORAIENSIS 8kg, brush-cherry seed 8kg and orange peel 6kg.
Preparation method is obtained the Chinese medicine composition for relaxing bowel with embodiment 1.
According to common process, above-mentioned Chinese medicine composition medicinal powder is mixed with auxiliary material, dry granulation, whole grain is obtained this hair
The granule of the bright Chinese medicine composition for relaxing bowel.
Chinese medicine composition and its preparation that embodiment 8, the present invention relax bowel
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg, orange peel 4kg, lotus seeds 4kg,
Lily 3kg, matrimony vine 3kg and ginger 2kg.
Preparation method：The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10
Mesh sieve, adds 132kg water, soaks 2h, and filtering is subsequently added into the ethanol that 198kg concentration of volume percent is 90%, in ultrasonic wave
Frequency is 30kHz, and power is 200W, and Extracting temperature at 40 DEG C to extract 1 time, and each 40min, filtering, merging filtrate, filtrate is true
Sky is concentrated under reduced pressure into the 1/4 of original volume, and concentrate A is obtained；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 12kg water, refluxing extraction 1h, filtering, filter vacuum to subtract
Pressure is concentrated into the 1/4 of original volume, and orange peel concentrate is obtained；
The mixing of S3, the lotus seeds for taking formula ratio, lily and matrimony vine, crushed 10 mesh sieves, added 40kg water, refluxing extraction 2h,
Filtering, filter vacuum is concentrated under reduced pressure into the 1/4 of original volume, and concentrate B is obtained；
S4, the ginger for taking formula ratio, section, add 4kg concentration of volume percent be 60% ethanol, refluxing extraction 1h,
Filtering, filter vacuum is concentrated under reduced pressure into the 1/3 of original volume, and ginger concentrate is obtained；
S5, by the concentrate A, orange peel concentrate, concentrate B and ginger concentrate mix, mixed liquor is in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.10 is concentrated into, drying under reduced pressure crushed 80 mesh sieves, the Chinese traditional medicine composition for relaxing bowel is obtained
Thing.
Separately taking honey carries out refined honey, and the refined honey for obtaining compares 1 with above-mentioned Chinese medicine composition medicinal powder according to weight:1 mixes, pill
Block, rubs ball bar with the hands, and pill grain, the weight 0.2g per ball is obtained the honeyed bolus of the Chinese medicine composition that the present invention relaxes bowel.
Chinese medicine composition and its preparation that embodiment 9, the present invention relax bowel
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg, orange peel 4kg, lotus seeds 7kg,
Lily 6kg, matrimony vine 6kg and ginger 5kg.
Preparation method：The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10
Mesh sieve, adds 198kg water, soaks 2h, and filtering is subsequently added into the ethanol that 297kg concentration of volume percent is 95%, in ultrasonic wave
Frequency is 40kHz, and power is 300W, and Extracting temperature at 50 DEG C to extract 2 times, and each 30min, filtering, merging filtrate, filtrate is true
Sky is concentrated under reduced pressure into the 1/3 of original volume, and concentrate A is obtained；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 24kg water, refluxing extraction 2h, filtering, filter vacuum to subtract
Pressure is concentrated into the 1/4 of original volume, and orange peel concentrate is obtained；
The mixing of S3, the lotus seeds for taking formula ratio, lily and matrimony vine, crushed 10 mesh sieves, added 133kg water, refluxing extraction 3h,
Filtering, filter vacuum is concentrated under reduced pressure into the 1/3 of original volume, and concentrate B is obtained；
S4, the ginger for taking formula ratio, section, add 20kg concentration of volume percent be 70% ethanol, refluxing extraction 2h,
Filtering, filter vacuum is concentrated under reduced pressure into the 1/4 of original volume, and ginger concentrate is obtained；
S5, by the concentrate A, orange peel concentrate, concentrate B and ginger concentrate mix, mixed liquor is in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.20 is concentrated into, drying under reduced pressure crushed 80 mesh sieves, the Chinese traditional medicine composition for relaxing bowel is obtained
Thing.
Separately taking honey carries out refined honey, and the refined honey for obtaining compares 1 with above-mentioned Chinese medicine composition medicinal powder according to weight:1 mixes, pill
Block, rubs ball bar with the hands, and pill grain, the weight 0.2g per ball is obtained the honeyed bolus of the Chinese medicine composition that the present invention relaxes bowel.
Chinese medicine composition and its preparation that embodiment 10, the present invention relax bowel
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg, orange peel 4kg, lotus seeds 6kg,
Lily 5kg, matrimony vine 5kg and ginger 3kg.
Preparation method：The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10
Mesh sieve, adds 165kg water, soaks 2h, and filtering is subsequently added into the ethanol that 231kg concentration of volume percent is 95%, in ultrasonic wave
Frequency is 35kHz, and power is 200W, and Extracting temperature at 45 DEG C to extract 2 times, and each 30min, filtering, merging filtrate, filtrate is true
Sky is concentrated under reduced pressure into the 1/3 of original volume, and concentrate A is obtained；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 20kg water, refluxing extraction 1h, filtering, filter vacuum to subtract
Pressure is concentrated into the 1/3 of original volume, and orange peel concentrate is obtained；
The mixing of S3, the lotus seeds for taking formula ratio, lily and matrimony vine, crushed 10 mesh sieves, added 96kg water, refluxing extraction 2h,
Filtering, filter vacuum is concentrated under reduced pressure into the 1/3 of original volume, and concentrate B is obtained；
S4, the ginger for taking formula ratio, section, add 9kg concentration of volume percent be 65% ethanol, refluxing extraction 2h,
Filtering, filter vacuum is concentrated under reduced pressure into the 1/3 of original volume, and ginger concentrate is obtained；
S5, by the concentrate A, orange peel concentrate, concentrate B and ginger concentrate mix, mixed liquor is in vacuum decompression
The medicinal extract that relative density at 60 DEG C is 1.20 is concentrated into, drying under reduced pressure crushed 80 mesh sieves, the Chinese traditional medicine composition for relaxing bowel is obtained
Thing.
Separately taking honey carries out refined honey, and the refined honey for obtaining compares 1 with above-mentioned Chinese medicine composition medicinal powder according to weight:1 mixes, pill
Block, rubs ball bar with the hands, and pill grain, the weight 0.2g per ball is obtained the honeyed bolus of the Chinese medicine composition that the present invention relaxes bowel.
Chinese medicine composition and its preparation that embodiment 11, the present invention relax bowel
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg, orange peel 4kg, lotus seeds 6kg,
Lily 5kg, matrimony vine 5kg and ginger 3kg.
Preparation method is obtained the Chinese medicine composition for relaxing bowel with embodiment 10.
According to common process, above-mentioned Chinese medicine composition medicinal powder is taken, it is 65% ethanol to add 3 times of volume fractions of medicinal powder weight,
It is sufficiently stirred for, 24h is stood at room temperature, take supernatant, ethanol is recovered under reduced pressure up to supernatant is without alcohol taste, obtains liquid；Described in
The water of 6 times of liquid weights is added to be diluted in liquid, filtering obtains final product the mouth of the Chinese medicine composition that the present invention relaxes bowel after standing
Take liquid.
Comparative example 1, ancient prescription wuren pills
Peach kernel 30g, almond 30g, SEMEN PINI KORAIENSIS 3g, seed of Oriental arborvitae 15g, brush-cherry seed 3g and orange peel 120g, crushed 80 mesh sieves, separately
Taking honey carries out refined honey, and the refined honey for obtaining compares 1 with above-mentioned medicinal powder according to weight:1 mixes, pill block, stranding ball bar, pill grain, often
Ball weight 0.2g, that is, be obtained this comparative example honeyed bolus.
Comparative example 2
Formula：Lotus seeds 6kg, lily 5kg, matrimony vine 5kg and ginger 3kg.
Preparation method reference implementation example 10, is obtained this comparative example honeyed bolus.
Comparative example 3
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg, orange peel 4kg, lotus seeds 6kg
With lily 5kg.
Preparation method reference implementation example 10, is obtained the honeyed bolus of this comparative example.
Comparative example 4
Formula：Semen armeniacae amarae 8kg, peach kernel 7kg, fructus cannabis 6kg, SEMEN PINI KORAIENSIS 6kg, brush-cherry seed 6kg, orange peel 4kg, matrimony vine 5kg
With ginger 3kg.
Preparation method reference implementation example 10, is obtained the honeyed bolus of this comparative example.
Comparative example 5
The formula of this comparative example is same as in Example 10.
And preparation method is compared with Example 10, this comparative example is differed only in：S4, the ginger for taking formula ratio, section,
Add 9kg water, refluxing extraction 2h, filtering, filter vacuum to be concentrated under reduced pressure into the 1/3 of original volume, ginger concentrate is obtained.
Therapeutic effect of the Chinese medicine composition that test example one, the present invention relax bowel to constipation of slow-remove type mouse model
1. test objective
Experimental mice hypodermic injection morphine induction sets up constipation of slow-remove type mouse model, records stool in mice weight,
Compare administration group and control group mice Colonic transit activity using the experiment of activated carbon administration by gavage.
2. material
Specific-pathogen free SPF grades of ICR mouse 86, male and female half and half, 22~26 grams of body weight；Mouse metabolism cage (Suzhou Feng Shi
Experimental animal company)；Hydrochloride for injection morphine (Shenyang No. 1 Pharmaceutical Factory, specification 10mg/ branch)；Physiological saline；Primary antibody (sc-
168, Santa Cruz Biotechnology, Inc, 200mg/L)；Secondary antibody (goat anti-rabbit antibody, Zhong Shan biotechnologies company).
3. test methods and procedures
The foundation of 3.1 constipation of slow-remove type mouse models
ICR mouse 86, mouse is inserted in 86 mouse metabolism cages, and SPF grades of environment is raised.After adaptability is fed 3 days, administration
Group and model control group mouse subcutaneous injection morphine hydrochloride 2.5mg/ (kgd), Normal group injection normal saline.Often
3 days records mouse stool grain number, stool dry weight and a Mouse Weight, calculate average daily defecation weight (g) of mouse.It is average daily with mouse
Feces volume is reduced, and average daily feces volume has significant difference as constipation of slow-remove type mouse model compared with Normal group
The mark being successfully established, modeling success after stop drug administration by injection.
The measure of the average daily defecation weight of 3.2 mouse
80 mouse of (raise the 46th day from) after modeling success are given, 1~3,8~10 groups of embodiment, right is randomly divided into
Ratio 1,2, Normal group and model control group, every group 8.According to following Dosage Regimens Dosage：
1 group of embodiment：Honeyed bolus obtained in Example 1, smashs to pieces, adds honeyed bolus to weigh 4 times of distilled water of amount, stirs evenly, gavage
Administration, dosage is 6.0g/kg.
Obtained in 1 group of difference Example of 2,3,8,9,10 groups of embodiment and comparative example 2,3,8,9,10 and comparative example 1,2
Honeyed bolus is administered, and dosage regimen is with 1 group of embodiment.Normal group and model control group give isometric distilled water.
It is administered once a day, every 1 day record mouse stool grain number, stool dry weight and a Mouse Weight, calculates mouse
Average daily defecation weight (g).The average daily feces volume of mouse is reduced compared with normal group, shows that constipation of slow-remove type degree increases.
3.3 enteron aisle transfer functions are determined
First grain melena efflux time is determined with activated carbon administration by gavage.The all mouse fasting being discontinued 1 week 24 hours, it is oral to fill
Enter 100mg/ml carbon suspensioning liquids 2ml.Timing when activated carbon gavage is finished, what record was discharged from gavage to first grain melena
Time.First grain melena efflux time is more long to show that constipation of slow-remove type degree is bigger.
The statistical procedures of 3.4 test datas
The statistical packages of experimental data typing SPSS 20.0, statistical method is checked from t.
4. result
Influence of each administration group of table 1 to constipation of slow-remove type mouse
Compare with Normal group, ##p<0.01；Compared with model control group, * p<0.05, * * p<0.01.
1 is seen the above table, animal test results show：
(1) compared with Normal group, the average daily feces volume of model control group mouse, first grain melena efflux time are respectively provided with pole
Significant difference (p<0.01), show that constipation of slow-remove type mouse model is built successfully；
(2) compared with model control group mouse, 1~3 group of average daily feces volume of mouse of embodiment, first grain melena efflux time tool
There is significant difference (p<0.05), 8~10 groups of average daily feces volumes of mouse of embodiment, first grain melena efflux time have pole conspicuousness
Difference (p<0.01), and comparative example 1 and 2 groups do not possess significant difference, this shows that Chinese medicine composition of the present invention has ease constipation
Effect of defaecation, can be obviously improved mouse feces volume, strengthen mouse intestinal propulsive force, alleviate the disease of slow-remove type mice with constipation
Shape, and it is more obvious than the effect of ancient prescription wuren pills, and 8~10 groups of embodiment is better than 1~3 group of embodiment, wherein with embodiment 10
The action effect of Chinese medicine composition is optimal, is highly preferred embodiment of the present invention.
(3) test during, without dead mouse, also find no mouse occur the bodily form become thin, lose hair or feathers, activity reduce, vomit
The undesirable condition such as tell.
Therapeutic effect of the Chinese medicine composition that test example two, the present invention relax bowel to old weakness constipation
1. clinical data
In 1.1 volunteers of physical data 150, man 80, female 70, age reckling 59 years old, the maximum 81 years old, averagely
68 years old, the course of disease was most short 2 months, most long 6 years.With organic diseases such as the carcinoma of the rectum, rectal polyp, anal haemorrhoids in clinical treatment
And cause constipation person to exclude within statistics.
1.2 diagnostic criteria references《Disease of tcm Standardization of diagnosis and curative effect》.Training inspection excludes organic disease, defecation time
It is long, 3 days or more than 3 days 1 time, or excrement dries, and hardens, though or without the powerless discharge of constipation, long without awareness of defecation.Patient is with few abdomen
Discomfort, receives poor deficiency of food, and mood is unhappy, tired mind, patient with insomnia (course of disease is most short 2 months, most long 5 years), few abdomen secret anguish.
Qi-deficiency type 30 in 150, blood-deficiency type 33, YIN-deficiency type 42, deficiency of yang type 45, each parting is grouped at random.
2. treatment method
It is divided into 3 groups, embodiment 3, embodiment 10 and honeyed bolus obtained in comparative example 1 is taken respectively, respectively takes 1 dose, 1 sooner or later daily
The ball of agent 30.It is within 10 days 1 course for the treatment of, treats 3 courses for the treatment of.Patient's moderate exercise is advised during medication, vegetable and fruit is eaten more, drunk more water, stopped
Other cathartics are used, adheres to that timing is defecated daily.
3. Ureteral Calculus
3.1 criterion of therapeutical effect references《Disease of tcm Standardization of diagnosis and curative effect》.(1) constipation：Cure：Defecation 1 time in 2 days, just matter
Turn profit, defecation is unobstructed；Take a turn for the better：Defecation 1 time in 3 days, just matter turn profit, defecation owes smooth；It is invalid：Constipation symptom is without any slow after medication
Solution.(2) sleep：Cure：Nighttime sleep was slept deep more than 6 hours；Take a turn for the better：Nighttime sleep increases by more than 2 hours,
Depth of sleep increases；It is invalid：Sleep state does not improve after medication.
3.2 therapeutic effects (are shown in Table 2)
The treatment results of table 2
2 are seen the above table, clinical test results show：
(1) embodiment of the present invention 3 and the honeyed bolus of embodiment 10 are to old qi-deficiency type, blood-deficiency type, YIN-deficiency type and astriction of insufficiency of yang type
Specific obvious therapeutic effect, and more excellent compared with the therapeutic effect of ancient prescription wuren pills, the wherein average total effective rate of the honeyed bolus of embodiment 3
Close to 90%, and the average total effective rate of the honeyed bolus of embodiment 8 is 100%, and therapeutic effect is notable.
(2) honeyed bolus of the embodiment of the present invention 10 can improve insomnia, extend the length of one's sleep, increase Depth of sleep, improve sleep matter
Amount, total effective rate reaches 92%.And embodiment 3 and the honeyed bolus of comparative example 1 and without the effect for improving insomnia.
3.3 recurrences
After 3 courses for the treatment of terminate, each packet healing person's withdrawal is paid a return visit healing person after 1 month, investigation recurrence feelings
Condition.The healing person 22 for taking the honeyed bolus of embodiment 3, recidivist 8 after healing, recurrence rate 36.4%；Take the honeyed bolus of embodiment 10
Healing person 31, recidivist 5 after healing, recurrence rate 16.1%；The healing person 9 for taking the honeyed bolus of comparative example 1 is multiple after healing
Originator 8, recurrence rate 88.9%.It can be seen that, to take the Chinese medicine composition that relaxes bowel of the present invention and control that recurrence rate after healing is low, curative effect is true
Cut.
The study on the stability of the Chinese medicine composition that test example three, the present invention relax bowel
According to《Chinese Pharmacopoeia》(2015) are entered to the embodiment of the present invention 3,10 and comparative example 1, the stability of 3~5 honeyed bolus
Row long term test, under the conditions of commercially available back, places under conditions of 25 DEG C ± 2 DEG C, relative humidity 60% ± 10%, respectively at
3rd, sample within 6,9,12,18,24 months, check proterties, discriminating, microbial limit and degree of becoming sour.Result see the table below 3.
Character description：Rufous honeyed bolus, gas is micro-, mildly bitter flavor.
Differentiate：Qualitive test is carried out using thin-layered chromatography.
Limit test of microbe：According to the rules various pills must not detect the miscellaneous bacterias such as mite living, mite ovum and EHEC,
Fungi；Detected by microbial decolorization.
Become sour degree：After taking a certain amount of sample, plus appropriate water dissolves, extracted 3 times with petroleum ether (30~60 DEG C) 20ml,
Combining extraction liquid, gained oil is placed in 50ml conical flasks after water-bath is volatilized, plus hydrochloric acid 5ml, is mixed, and marble 3~4 is added immediately
Grain, stoppers the cork for having installed phloroglucin test paper, and 20min are placed in about 25 DEG C of water-baths, and the test paper person that do not redden is feminine gender,
"-" represents reaction negative, and "+" represents reacting positive.(principle：Unrighted acid is oxidized and becomes sour, and produces peroxide,
Peroxide is extremely unstable, may proceed to oxidation, produces aldehydes, ketone and organic acid etc., and aldehydes, ketone are penetrating odors
Main source, that is, rancid flavor.)
Table 3
3 are seen the above table, long-term test results show：
(1) honeyed bolus of embodiment 1 storage there occurs within 12 months it is rotten, the ancient prescription wuren pills of comparative example 1 storage there occurs within 9 months change
Matter, and the stability of the honeyed bolus of embodiment 10 is high, long shelf-life, appearance character, diagnostic characteristics, microbial limit etc. after depositing 2 years
Meet pharmacopoeial requirements, and no become sour.
(2) compared with Example 10, comparative example 3 and comparative example 4 change formula, comparative example 5 and change preparation method, its
The bad stability of honeyed bolus, shortened shelf life.
The above is only the preferred embodiment of the present invention, it is noted that it is right that above-mentioned preferred embodiment is not construed as
Limitation of the invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (6)
1. a kind of Chinese medicine composition for relaxing bowel, it is characterised in that be prepared from by the raw material of following weight portion meter：Semen armeniacae amarae
6~12 parts, 6~12 parts of peach kernel, 3~8 parts of fructus cannabis, 3~8 parts of SEMEN PINI KORAIENSIS, 3~8 parts of brush-cherry seed, 2~6 parts of orange peel, lotus seeds 4~
2~5 parts of 7 parts, 3~6 parts of lily, 3~6 parts of matrimony vine and ginger.
2. the Chinese medicine composition for relaxing bowel according to claim 1, it is characterised in that by the raw material of following weight portion meter
It is prepared from：8 parts of semen armeniacae amarae, 7 parts of peach kernel, 6 parts of fructus cannabis, 6 parts of SEMEN PINI KORAIENSIS, 6 parts of brush-cherry seed, 4 parts of orange peel, 6 parts of lotus seeds, lily
3 parts of 5 parts, 5 parts of matrimony vine and ginger.
3. the Chinese medicine composition for relaxing bowel according to claim 1 and 2, it is characterised in that the Chinese medicine composition is
Granule, capsule, oral liquid and pill.
4. the preparation method of the Chinese medicine composition for relaxing bowel according to claim 1 and 2, it is characterised in that including with
Lower step：
The mixing of S1, the semen armeniacae amarae for taking formula ratio, peach kernel, fructus cannabis, SEMEN PINI KORAIENSIS and brush-cherry seed, crushes, and crosses 10 mesh sieves, adds 4~6
The water of times medicinal material amount, soaks 1.5~2h, and filtering is subsequently added into 6~9 times of ethanol of medicinal material amount, ultrasonic frequency be 30~
40kHz, power is 200~300W, and to be extracted at 40~50 DEG C 1~2 time, 30~40min, filtering, merge Extracting temperature every time
Filtrate, filter vacuum is concentrated under reduced pressure into the 1/4~1/3 of original volume, and concentrate A is obtained；
S2, the orange peel for taking formula ratio, crush, and cross 10 mesh sieves, add 3~6 times of water of medicinal material amount, 1~2h of refluxing extraction to filter,
Filter vacuum is concentrated under reduced pressure into the 1/4~1/3 of original volume, and orange peel concentrate is obtained；
The mixing of S3, the lotus seeds for taking formula ratio, lily and matrimony vine, crushed 10 mesh sieves, added 4~7 times of water of medicinal material amount, and backflow is carried
2~3h is taken, is filtered, filter vacuum is concentrated under reduced pressure into the 1/4~1/3 of original volume, concentrate B is obtained；
S4, the ginger for taking formula ratio, section add 2~4 times of ethanol of medicinal material amount, 1~2h of refluxing extraction, filtering, filter vacuum
The 1/4~1/3 of original volume is concentrated under reduced pressure into, ginger concentrate is obtained；
S5, by the concentrate A, orange peel concentrate, concentrate B and ginger concentrate mix, mixed liquor is in vacuum-concentrcted
Relative density is 1.10~1.20 medicinal extract to 60 DEG C, and drying under reduced pressure is crushed, and the Chinese medicine composition for relaxing bowel is obtained.
5. the preparation method of the Chinese medicine composition for relaxing bowel according to claim 4, it is characterised in that the step S1
The concentration of volume percent of middle ethanol is 90~95%.
6. the preparation method of the Chinese medicine composition for relaxing bowel according to claim 4, it is characterised in that the step S4
The concentration of volume percent of middle ethanol is 60~70%.
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| CN107050351B (en) * | 2017-03-02 | 2020-08-21 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition for relaxing bowel and preparation method and application thereof |
| CN109090612A (en) * | 2018-11-02 | 2018-12-28 | 杭州璧华生物科技有限公司 | A kind of Chinese medicinal food and preparation method of relax bowel and defecation |
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