CN105519731A - Dried tangerine peel tea effervescent tablet and preparation method thereof - Google Patents
Dried tangerine peel tea effervescent tablet and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a dried tangerine peel tea effervescent tablet which includes the following components in parts by weight: 1-4 parts of dried tangerine peel tea extract dried powder, 4-6 parts of bird's nest extract, 8-12 parts of white granulated sugar, 25-35 parts of sodium bicarbonate, 12-16 parts of polyethylene glycol, and 4-8 parts of peppermint powder essence. The present invention also discloses a preparation method of the dried tangerine peel tea effervescent tablet. The preparation method can sufficiently extract the medicinal ingredients in the dried tangerine peels. The fatty liver prevention effect is improved.
Description
Technical field
The invention belongs to the processing technique field of health protection tea, be specifically related to a kind of orange peel tea effervescent tablet, the invention still further relates to a kind of preparation method of orange peel tea effervescent tablet.
Background technology
Orange peel tea is a kind of folks of china Chinese traditional herbs, one of cold tea that Cantonese often drinks.The inside composition comprises dried orange peel and tealeaves etc., utilizes dried orange peel and tealeaves to carry out split, the orange peel tea of making, can be referred to as " medicinal herb tea ".The i.e. property of medicine health-care effect the first of orange peel tea, the object that tea ceremony is tasted is anti-secondarily.Often drink orange peel tea, have and relieve summer heat summer, relieving cough and reducing sputum, the health cares such as strengthening spleen and nourishing stomach, can also treat the diseases such as the taste stagnation of the circulation of vital energy, abdominal distension stomachache, indigestion, poor appetite.Also prevention effect is had to diseases such as high fat of blood, hypertension, fatty liver, myocardial infarctions.This is a out and out health protection tea.
At present, the use for orange peel tea generally still rests on traditional cold tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of orange peel tea is obviously reduced simultaneously, greatly hinders the promotion and application of orange peel tea.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium acid carbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after effervescent tablet puts into water, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegration of tablet and thawing, and the bubble that disintegration sometimes produces also can make tablet roll up and down in water, accelerates its disintegration and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as carbonated drink when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
Cold tea is as Chinese tradition drink, and the cold tea paving big and small in In Guangdong Province is seen everywhere, and pouplarity has some idea of.But traditional herb tea decocts to waste time and energy, the rhythm of life of urbanite is but more and more faster now, and younger generation few people are ready to buy specially a watt pot and spend several hours and go decoction one to take cold tea.
Current does not also have dried orange peel effervescent tablet, exist in the dried orange peel effervescent tablet that the conventional method of the present inventor is prepared disintegration slowly, active principle is difficult to the problem that is dissolved out.
Summary of the invention
The object of this invention is to provide a kind of orange peel tea effervescent tablet, the active ingredient solving the orange peel tea existed in prior art is difficult to the problem be dissolved out, single orange peel tea pharmacodynamic feature is single.
Another object of the present invention is to provide the preparation method of orange peel tea effervescent tablet.
First technical scheme of the present invention is, a kind of orange peel tea effervescent tablet, following component is comprised: orange peel tea extracts 1 part-4 parts, dry powder according to mass parts, birds nest extract 4 parts-6 parts, white granulated sugar 8 parts-12 parts, sodium acid carbonate 25 parts-35 parts, polyethylene glycol 12 parts-16 parts, peppermint powdered flavor 4 parts-8 parts.
Further, orange peel tea extraction dry powder is obtained by following steps:
Step 1.1, tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 45-60min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract; Wherein, the sieve mesh of screening is 60-80 order;
60the dosage of Co-gamma-ray irradiation is 2-24kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 1:1500-3:1000; Enzymatic hydrolysis condition is temperature is 30-50 DEG C; Enzymolysis time is 20-100min;
Step 1.2, spraying dry: the medicinal extract obtained in step 1.1 is carried out spraying dry and make orange peel tea extraction dry powder; Wherein, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 28000r/min-30000r/min.
Further, birds nest extract is prepared by following steps: after bird's nest oven dry, pulverizing, the dosage through x ray irradiation x is 2-24kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 60-95% ethanol percolation, residue volatilizes ethanol, adds 4-8 times of water gaging refluxing extraction 1-3 time, and each 4 hours-8 hours, reflux temperature was 45 DEG C-75 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract.
Second technical scheme of the present invention is, a kind of preparation method of orange peel tea effervescent tablet, comprises the following steps:
Step 1, prepare orange peel tea extract dry powder;
Step 2, prepare birds nest extract;
Step 3, weighing: weigh following material according to mass parts: orange peel tea extracts 1 part-4 parts, dry powder, birds nest extract 4 parts-6 parts, white granulated sugar 8 parts-12 parts, sodium acid carbonate 25 parts-35 parts, polyethylene glycol 12 parts-16 parts, peppermint powdered flavor 4 parts-8 parts;
Step 4, grinding: by load weighted white granulated sugar, sodium acid carbonate, polyethylene glycol, peppermint powdered flavor grinds, and crosses 50 mesh sieves, adds orange peel tea and extracts dry powder and birds nest extract, mix;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare orange peel tea effervescent tablet.
Further, prepare orange peel tea extraction dry powder in step 1 to be specially:
Step 1.1, tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 45-60min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract;
Step 1.2, spraying dry: the medicinal extract obtained in step 1.1 is carried out spraying dry and make orange peel tea extraction dry powder.
Further, in step 1.1, the sieve mesh of screening is 60-80 order;
60the dosage of Co-gamma-ray irradiation is 2-24kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 1:1500-3:1000; Enzymatic hydrolysis condition is temperature is 30-50 DEG C; Enzymolysis time is 20-100min.
Further, in step 1.2, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 28000r/min-30000r/min.
Further, in step 2, birds nest extract is prepared by following steps: after bird's nest oven dry, pulverizing, the dosage through x ray irradiation x is 2-24kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 60-95% ethanol percolation, residue volatilizes ethanol, adds 4-8 times of water gaging refluxing extraction 1-3 time, and each 4 hours-8 hours, reflux temperature was 45 DEG C-75 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract.
Further, in step 5, grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 72 DEG C-78 DEG C, and pressure is 0.3MP-0.5MP.
The invention has the beneficial effects as follows: the disintegration time limited of the orange peel tea effervescent tablet that this formula and preparation method obtain can reach 110s, solve the slow difficult problem of Effervescent tablet disintegration, screening by the proportioning to orange peel tea effervescent tablet and the screening to gas-producing disintegrant and lubricant etc., make orange peel tea effervescent tablet of the present invention obtain best effervesce effect.
Effective component in dried orange peel can extract by the present invention fully; The preventive effect of fatty liver is improved.
The present invention organically combines effervescent tablet preparation formulation and traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of cold tea greatly.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The invention provides a kind of orange peel tea effervescent tablet, following component is comprised: orange peel tea extracts 1 part-4 parts, dry powder, birds nest extract 4 parts-6 parts, white granulated sugar 8 parts-12 parts, sodium acid carbonate 25 parts-35 parts according to mass parts, polyethylene glycol 12 parts-16 parts, peppermint powdered flavor 4 parts-8 parts.
The present invention also provides a kind of preparation method of orange peel tea effervescent tablet, comprises the following steps:
Step 1, prepare orange peel tea extract dry powder:
Step 1.1, tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 45-60min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract; Wherein, the sieve mesh of screening is 60-80 order;
60the dosage of Co-gamma-ray irradiation is 2-24kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 1:1500-3:1000; Enzymatic hydrolysis condition is temperature is 30-50 DEG C; Enzymolysis time is 20-100min;
Step 1.2, spraying dry: the medicinal extract obtained in step 1.1 is carried out spraying dry and make orange peel tea extraction dry powder; Wherein, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 28000r/min-30000r/min;
Step 2, prepare birds nest extract: after being dried by bird's nest, pulverizing, the dosage through x ray irradiation x is 2-24kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 60-95% ethanol percolation, residue volatilizes ethanol, adds 4-8 times of water gaging refluxing extraction 1-3 time, and each 4 hours-8 hours, reflux temperature was 45 DEG C-75 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract;
Step 3, weighing: weigh following material according to mass parts: orange peel tea extracts 1 part-4 parts, dry powder, birds nest extract 4 parts-6 parts, white granulated sugar 8 parts-12 parts, sodium acid carbonate 25 parts-35 parts, polyethylene glycol 12 parts-16 parts, peppermint powdered flavor 4 parts-8 parts;
Step 4, grinding: by load weighted white granulated sugar, sodium acid carbonate, polyethylene glycol, peppermint powdered flavor grinds, and crosses 50 mesh sieves, adds orange peel tea and extracts dry powder and birds nest extract, mix;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare orange peel tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 72 DEG C-78 DEG C, and pressure is 0.3MP-0.5MP.
Embodiment 1
A preparation method for orange peel tea effervescent tablet, comprises the following steps: tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 45min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract; Wherein, the sieve mesh of screening is 60 orders;
60the dosage of Co-gamma-ray irradiation is 2kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 1:1500; Enzymatic hydrolysis condition is temperature is 30 DEG C; Enzymolysis time is 20min; The medicinal extract obtained is carried out spraying dry and make orange peel tea extraction dry powder; Wherein, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 28000r/min; After bird's nest oven dry, pulverizing, the dosage through x ray irradiation x is 2kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 60% ethanol percolation, residue volatilizes ethanol, adds 4 times of water gaging refluxing extraction 1 time, each 4 hours, and reflux temperature is 45 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract; Following material is weighed: orange peel tea extracts 1 part, dry powder, birds nest extract 6 parts, white granulated sugar 8 parts, sodium acid carbonate 35 parts, polyethylene glycol 12 parts, peppermint powdered flavor 8 parts according to mass parts; By load weighted white granulated sugar, sodium acid carbonate, polyethylene glycol, peppermint powdered flavor grinds, and crosses 50 mesh sieves, adds orange peel tea and extracts dry powder and birds nest extract, mix; The mixed powder prepared is granulated, flattens, prepare orange peel tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 72 DEG C, and pressure is 0.3MP.
Embodiment 2
A preparation method for orange peel tea effervescent tablet, comprises the following steps: tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 60min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract; Wherein, the sieve mesh of screening is 60-80 order;
60the dosage of Co-gamma-ray irradiation is 24kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 3:1000; Enzymatic hydrolysis condition is temperature is 50 DEG C; Enzymolysis time is 100min; The medicinal extract obtained is carried out spraying dry and make orange peel tea extraction dry powder; Wherein, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 30000r/min; After bird's nest oven dry, pulverizing, the dosage through x ray irradiation x is 24kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 95% ethanol percolation, residue volatilizes ethanol, adds 8 times of water gaging refluxing extraction 3 times, each 8 hours, and reflux temperature is 75 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract; Following material is weighed: orange peel tea extracts 4 parts, dry powder, birds nest extract 4 parts, white granulated sugar 12 parts, sodium acid carbonate 25 parts, polyethylene glycol 16 parts, peppermint powdered flavor 4 parts according to mass parts; By load weighted white granulated sugar, sodium acid carbonate, polyethylene glycol, peppermint powdered flavor grinds, and crosses 50 mesh sieves, adds orange peel tea and extracts dry powder and birds nest extract, mix; The mixed powder prepared is granulated, flattens, prepare orange peel tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 78 DEG C, and pressure is 0.5MP.
Embodiment 3
A preparation method for orange peel tea effervescent tablet, comprises the following steps: tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 50min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract; Wherein, the sieve mesh of screening is 70 orders;
60the dosage of Co-gamma-ray irradiation is 12kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 1:1000; Enzymatic hydrolysis condition is temperature is 40 DEG C; Enzymolysis time is 60min; The medicinal extract obtained is carried out spraying dry and make orange peel tea extraction dry powder; Wherein, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 29000r/min; After bird's nest oven dry, pulverizing, the dosage through x ray irradiation x is 12kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 80% ethanol percolation, residue volatilizes ethanol, adds 4-8 times of water gaging refluxing extraction 2 times, each 6 hours, and reflux temperature is 60 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract; Following material is weighed: orange peel tea extracts 3 parts, dry powder, birds nest extract 5 parts, white granulated sugar 10 parts, sodium acid carbonate 30 parts, polyethylene glycol 14 parts, peppermint powdered flavor 6 parts according to mass parts; By load weighted white granulated sugar, sodium acid carbonate, polyethylene glycol, peppermint powdered flavor grinds, and crosses 50 mesh sieves, adds orange peel tea and extracts dry powder and birds nest extract, mix; The mixed powder prepared is granulated, flattens, prepare orange peel tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 75 DEG C, and pressure is 0.4MP.
Comparative example
The effervescent tablet that common process prepares.
Below in conjunction with disintegration time limited, subjective appreciation, hardness, outward appearance evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the particle assembled.No longer include gas to solution to overflow and time difference T (s) of dissolving is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind study " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
4, the test of pesticide effectiveness
The routine patient of clinical observation 60, treatment group 30 example, control group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes orange peel tea effervescent tablet one week.
Diagnosis basis: the standard that disconnected standard is demonstrate,proved based on anemopyretic cold relevant in " disease of tcm Standardization of diagnosis and curative effect ", 1. heating, micro-aversion to wind and cold, nasal obstruction runny nose, sneeze, headache, general malaise.2. pink tongue or limit point red, platform book is yellow, superficial and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, bodily pain, runny nose, pharyngalgia, congestion of throat, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet traditional Chinese medical science anemopyretic cold card diagnostic criteria, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of lung, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be the gestational period, women breast-feeding their children, and physique allergy sufferers.
Control group: comparative example effervescent tablet, 3 times/d, 7d were 1 course for the treatment of.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard more than temperature decline 0.5C is onset, dropping to 37.4C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Treatment results: in table 2.
Contrast with embodiments of the invention 1-3 and comparative example, draw the following conclusions.
Table 1 comparing result
| Disintegration time limited (s) | Sensory evaluation scores (dividing) | Hardness (N) | |
| Embodiment 1 | 110s | 99 | 75N |
| Embodiment 2 | 132s | 88 | 59N |
| Embodiment 3 | 126s | 85 | 63N |
| Comparative example | 426s | 49 | 52N |
The observation of curative effect of this effervescent tablet of table 2 treatment anemopyretic cold patient
| Group | Total number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Embodiment 1 | 30 | 25 | 2 | 1 | 2 | 93.3％ |
| Embodiment 2 | 30 | 24 | 2 | 1 | 3 | 90％ |
| Embodiment 3 | 30 | 18 | 5 | 2 | 5 | 83.3％ |
| Comparative example | 30 | 6 | 4 | 5 | 15 | 50％ |
As shown in Table 2, illustrate that the effective component ratio in effervescent tablet of the present invention is easier to extract, effervescent tablet treatment anemopyretic cold effect of the present invention is higher than the effect of existing dried orange peel.
4.2, the immunoregulation effect of this effervescent tablet:
This effervescent tablet of table 3 is on the impact of Turnover of Mouse Peritoneal Macrophages phagocytic activity
| Group | Phagocytic rate (%) | Phagocytic index (%) |
| Comparative example | 33.46±4.09 | 1.12±0.26 |
| Embodiment 1 | 31.38±3.28* | 1.65±0.21 |
| Embodiment 2 | 37.50±2.95** | 1.57±0.21 |
| Embodiment 3 | 41.09±5.89** | 2.00±0.26** |
Note:
##p<0.01, compared with comparative example.
Effervescent tablet of the present invention comparatively can significantly improve the phagocytic rate of Turnover of Mouse Peritoneal Macrophages, can also significantly improve the phagocytic index of abdominal cavity phagocytic in embodiment 3, shows that dried orange peel effervescent tablet can improve hypoimmunity mice non-specific immune function.
1., according to the inventive method, the application manually produces 150 batches of orange peel tea effervescent tablets altogether, product percent of pass 100%;
2. according to national standard, the orange peel tea effervescent tablet term of validity 24 months, the applicant's reserved sample observing to 36 month, every quality index has not yet to see obvious change;
3. embodiment 1-3 and comparative example illustrate and the invention solves the slow difficult problem of Effervescent tablet disintegration, the screening by the proportioning to orange peel tea and the screening to gas-producing disintegrant and lubricant etc., make orange peel tea effervescent tablet of the present invention obtain best effervesce effect;
4. can be found out by above-mentioned result of the test, it is fast that orange peel tea effervescent tablet of the present invention has disintegration compared with prior art products, and good stability, the advantages such as weight differential is little, can provide more stable, effective, safe product for patient.
5. the dried orange peel effervescent tablet prepared, smooth appearance, uniform color, sweet and sour taste, this stable process conditions of experiment results proved is feasible.
Claims (9)
1. an orange peel tea effervescent tablet, is characterized in that, comprises following component according to mass parts: orange peel tea extracts 1 part-4 parts, dry powder, birds nest extract 4 parts-6 parts, white granulated sugar 8 parts-12 parts, sodium acid carbonate 25 parts-35 parts, polyethylene glycol 12 parts-16 parts, peppermint powdered flavor 4 parts-8 parts.
2. orange peel tea effervescent tablet according to claim 1, is characterized in that, described orange peel tea is extracted dry powder and obtained by following steps:
Step 1.1, tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 45-60min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract; Wherein, the sieve mesh of screening is 60-80 order;
60the dosage of Co-gamma-ray irradiation is 2-24kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 1:1500-3:1000; Enzymatic hydrolysis condition is temperature is 30-50 DEG C; Enzymolysis time is 20-100min;
Step 1.2, spraying dry: the medicinal extract obtained in step 1.1 is carried out spraying dry and make orange peel tea extraction dry powder; Wherein, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 28000r/min-30000r/min.
3. orange peel tea effervescent tablet according to claim 1, is characterized in that, described birds nest extract is prepared by following steps: after bird's nest oven dry, pulverizing, the dosage through x ray irradiation x is 2-24kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 60-95% ethanol percolation, residue volatilizes ethanol, adds 4-8 times of water gaging refluxing extraction 1-3 time, and each 4 hours-8 hours, reflux temperature was 45 DEG C-75 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract.
4. a preparation method for orange peel tea effervescent tablet, is characterized in that, comprises the following steps:
Step 1, prepare orange peel tea extract dry powder;
Step 2, prepare birds nest extract;
Step 3, weighing: weigh following material according to mass parts: orange peel tea extracts 1 part-4 parts, dry powder, birds nest extract 4 parts-6 parts, white granulated sugar 8 parts-12 parts, sodium acid carbonate 25 parts-35 parts, polyethylene glycol 12 parts-16 parts, peppermint powdered flavor 4 parts-8 parts;
Step 4, grinding: by load weighted white granulated sugar, sodium acid carbonate, polyethylene glycol, peppermint powdered flavor grinds, and crosses 50 mesh sieves, adds orange peel tea and extracts dry powder and birds nest extract, mix;
Step 5, the mixed powder prepared in step 4 to be granulated, flatten, prepare orange peel tea effervescent tablet.
5. the preparation method of orange peel tea effervescent tablet according to claim 4, is characterized in that, prepares orange peel tea extraction dry powder and be specially in described step 1:
Step 1.1, tangerine peel powder is broken into tea powder, crosses 50 mesh sieves, warp
60co-gamma-ray irradiation; Obtain Dried Tangerine Peel, and with cellulase, carry out enzymolysis, obtain enzymolysis processing liquid, by enzymolysis processing liquid ultrasonic process 45-60min at normal temperatures, obtain ultrasonic wave treatment fluid; With methyl alcohol dipping, filter, by filtrate simmer down to medicinal extract;
Step 1.2, spraying dry: the medicinal extract obtained in step 1.1 is carried out spraying dry and make orange peel tea extraction dry powder.
6. the preparation method of orange peel tea effervescent tablet according to claim 5, is characterized in that, in described step 1.1, the sieve mesh of screening is 60-80 order;
60the dosage of Co-gamma-ray irradiation is 2-24kGy, and the mass ratio of cellulase and Dried Tangerine Peel is 1:1500-3:1000; Enzymatic hydrolysis condition is temperature is 30-50 DEG C; Enzymolysis time is 20-100min.
7. the preparation method of orange peel tea effervescent tablet according to claim 5, is characterized in that, in described step 1.2, spray drying condition is: pressure: 55Mpa, feeding temperature: 60 DEG C, EAT: 190 DEG C, leaving air temp: 90 DEG C; Rotating speed is 28000r/min-30000r/min.
8. the preparation method of orange peel tea effervescent tablet according to claim 4, is characterized in that, in described step 2, birds nest extract is prepared by following steps: after bird's nest oven dry, pulverizing, the dosage through x ray irradiation x is 2-24kGy's
60co-gamma-ray irradiation, obtains bird's nest powder; Use 60-95% ethanol percolation, residue volatilizes ethanol, adds 4-8 times of water gaging refluxing extraction 1-3 time, and each 4 hours-8 hours, reflux temperature was 45 DEG C-75 DEG C, filters, by filtrate simmer down to medicinal extract; To the water-soluble solution of medicinal extract, filter, column purification on filtrate, QFF is as ion exchange column, and 10mMTris-HCl, pH8.0 Gradient elution, obtains birds nest extract.
9. the preparation method of orange peel tea effervescent tablet according to claim 4, is characterized in that, in described step 5, grain made parameter is aperture is 3.0, and compression ratio is 1:3, and temperature is 72 DEG C-78 DEG C, and pressure is 0.3MP-0.5MP.
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Application publication date: 20160427 |