CN106038975A - Traditional Chinese medicine composition having function of suppressing cough and preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition having function of suppressing cough and preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition having the function of suppressing cough and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following bulk drugs: 0.5-3.5 parts by weight of lily bulbs, 0.7-5.3 parts by weight of boat-fruited sterculia seeds, 0.5-3.5 parts by weight of radish seeds, 0.5-3.5 parts by weight of white mustard seeds, 0.5-3.5 parts by weight of perilla seeds, 0.7-5.3 parts by weight of bitter apricot kernels, and 0.7-5.3 parts by weight of bayberry leaves. In the traditional Chinese medicine composition, meridian entry, nature, and flavors of the traditional Chinese medicines are fully considered, and the matching ratio of the traditional Chinese medicines is selected according to a cooperation relationship of sovereign, minister, assistant and courier, so that the traditional Chinese medicines have a combined effect on suppressing cough. The traditional Chinese medicine composition only contains seven bulk drugs and is simple in composition and low in cost. Furthermore, the traditional Chinese medicine composition has a certain curative effect on treating diseases, such as trachitis, pharyngolaryngitis, asthma and tonsillitis.
Description
Technical field
The invention belongs to medicine or field of health care products, be specifically related to a kind of Chinese medicine composition with antitussive action and system thereof
Preparation Method and purposes.
Background technology
Modern medicine is thought, cough is the reflex action of protecting human body, by cough, makes the foreign body in respiratory tract or expectorant
Liquid is moved out.Cough is the total symptom that many reasons causes, both may be by caused by the disease of flu etc, it is also possible to
Caused by serious disease.Additionally, cough can cause cardiovascular, gastrointestinal tract, urogenital, nervous system, muscle skeleton and
The complication of the systems such as breathing, the most then affect healthy and quality of life, heavy then sb.'s illness took a turn for the worse, threat to life.
Chinese patent literature CN1448081A discloses: a kind of prophylactic treatment cough and asthma pear, peach and apricot honey sugar slab, by following
The raw material composition of proportioning: semen juglandis 30 parts, Semen pruni armeniacae 1.5 parts, Fructus Perillae 1 part, 0.5 part of Herba Ephedrae, Cordyceps 0.5 part, Fructus Lycii 1
Part, Bulbus Lilii 3 parts, Semen Sinapis Albae 1 part, Bulbus Fritillariae Cirrhosae 1 part etc..But, above-mentioned composition exists and forms complicated, relatively costly, preparation side
The shortcomings such as method is more complicated, thus limit its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost there is antitussive action
Medicine significant.
Summary of the invention
Therefore, the present invention provide one to treat therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost have
The Chinese medicine composition of antitussive action, and then its preparation method and purposes are provided.
For solving above-mentioned technical problem, the present invention is achieved through the following technical solutions:
The present invention provides a kind of Chinese medicine composition with antitussive action, and its crude drug includes:
Bulbus Lilii 0.5～3.5 weight portion, Semen Sterculiae Lychnophorae 0.7～5.3 weight portion, Semen Raphani 0.5～3.5 weight portion, Semen Sinapis Albae
0.5～3.5 weight portions, Fructus Perillae 0.5～3.5 weight portion, Semen Armeniacae Amarum 0.7～5.3 weight portion, Folium Myricae rubrae 0.7～5.3 weight portion.
Preferably, the above-mentioned Chinese medicine composition with antitussive action of the present invention, its crude drug includes:
Bulbus Lilii 1～3 weight portion, Semen Sterculiae Lychnophorae 1.5～4.5 weight portion, Semen Raphani 1～3 weight portion, Semen Sinapis Albae 1～3 weight
Part, Fructus Perillae 1～3 weight portion, Semen Armeniacae Amarum 1.5～4.5 weight portion, Folium Myricae rubrae 1.5～4.5 weight portion.
It is further preferred that the above-mentioned Chinese medicine composition with antitussive action of the present invention, its crude drug includes:
Bulbus Lilii 2 weight portion, Semen Sterculiae Lychnophorae 3 weight portion, Semen Raphani 2 weight portion, Semen Sinapis Albae 2 weight portion, Fructus Perillae 2 weight portion, hardship
Semen Armeniacae Amarum 3 weight portion, Folium Myricae rubrae 3 weight portion；Or
Bulbus Lilii 1 weight portion, Semen Sterculiae Lychnophorae 4.5 weight portion, Semen Raphani 1 weight portion, Semen Sinapis Albae 3 weight portion, Fructus Perillae 1 weight portion,
Semen Armeniacae Amarum 4.5 weight portion, Folium Myricae rubrae 1.5 weight portion；Or
Bulbus Lilii 3 weight portion, Semen Sterculiae Lychnophorae 1.5 weight portion, Semen Raphani 3 weight portion, Semen Sinapis Albae 1 weight portion, Fructus Perillae 3 weight portion,
Semen Armeniacae Amarum 1.5 weight portion, Folium Myricae rubrae 4.5 weight portion；Or
Bulbus Lilii 1.5 weight portion, Semen Sterculiae Lychnophorae 2.1 weight portion, Semen Raphani 1.7 weight portion, Semen Sinapis Albae 2.5 weight portion, Fructus Perillae 1.8
Weight portion, Semen Armeniacae Amarum 3.0 weight portion, Folium Myricae rubrae 4.3 weight portion.
It is further preferred that the above-mentioned Chinese medicine composition with antitussive action of the present invention, also include Spirit 250～750
Parts by volume, described weight portion is g/mL with the relation of parts by volume.
It is further preferred that the above-mentioned pharmaceutical composition with enhancing immunity and antifatigue effect of the present invention, also include
Spirit 500 parts by volume.
It is further preferred that the above-mentioned pharmaceutical composition with enhancing immunity and antifatigue effect of the present invention, described steaming
Evaporating wine is China white wine, and the number of degrees of described Spirit are 35～45 °.
It is further preferred that the above-mentioned pharmaceutical composition with enhancing immunity and antifatigue effect of the present invention, described in vain
Wine is 40 ° of China white wines.
The present invention also provides for the preparation method of a kind of above-mentioned Chinese medicine composition with antitussive action, comprises the following steps:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, mixed after grinding
Close or grind after mixing, make 50～150 mesh powder, toast at least 5min at 100～200 DEG C, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, be heated to reflux
Extracting at least 1 time, the water extraction of addition at least 1 weight times amount at least 0.5 hour, filters, merging filtrate, is concentrated into 50 DEG C every time
Relative density is 1.05-1.30, to obtain final product.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition with antitussive action of the present invention, including following step
Rapid:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, mixed after grinding
Close or grind after mixing, make 80～120 mesh powder, toast 10～30min at 130～170 DEG C, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, be heated to reflux
Extract 1～5 time, each water extraction 1 adding 1～5 weight times amount～3 hours, filter, merging filtrate, be concentrated into 50 DEG C relatively
Density is 1.10-1.25, to obtain final product.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition with antitussive action of the present invention, including following step
Rapid:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, mixed after grinding
Close or grind after mixing, make 100 mesh powder, toast 20min at 150 DEG C, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, be heated to reflux
Extracting 3 times, the water extraction of addition 3 weight times amount 2 hours, filter every time, and merging filtrate, being concentrated into 50 DEG C of relative densities is
1.10-1.25, to obtain final product.
The present invention also provides for the preparation method of a kind of above-mentioned Chinese medicine composition with antitussive action, comprises the following steps:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected
The Spirit of parts by volume, airtight immersion 7～10 days under room temperature, filter, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected
The Spirit of parts by volume, airtight dipping 1～3 times at 40～50 DEG C, every time dipping 1～5 day, cooling, filter, merge dipping
Liquid, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected
The Spirit of parts by volume, micro-boiling is extracted 1～4 time, extracts 1～3 hour every time, and cooling is filtered, united extraction liquid, to be obtained final product.
It is further preferred that the preparation side of the above-mentioned pharmaceutical composition with enhancing immunity and antifatigue effect of the present invention
Method, comprises the following steps:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected
The Chinese liquor of parts by volume, airtight immersion 8 days under room temperature, filter, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected
The Chinese liquor of parts by volume, airtight dipping 2 times at 45 DEG C, every time dipping 3 days, cooling, filter, merge impregnation liquid, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected
The Chinese liquor of parts by volume, micro-boiling is extracted 2 times, extracts 1.5 hours every time, and cooling is filtered, united extraction liquid, to be obtained final product.
It is further preferred that the preparation method of the above-mentioned Chinese medicine composition with antitussive action of the present invention, also include following
Step: by the crude drug of selected weight portion, be crushed to powder.
The present invention also provides for including the preparation of the above-mentioned Chinese medicine composition with antitussive action or including above-mentioned preparation side
What method prepared has the preparation of the Chinese medicine composition of antitussive action,
Described Chinese medicine composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule
Agent, powder, mixture, pill, granule, solution, syrup, soft extract, beverage, cookies, confection, cake or patch.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, anticorrosion
Agent, substrate etc..Filler includes: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.；Collapse
Solution agent includes: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low replacement hydroxyl
Third cellulose, cross-linked carboxymethyl cellulose are received；Lubricant includes: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, dioxy
SiClx etc.；Suspending agent includes: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc.；Bonding
Agent includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweeting agent includes: saccharin sodium, Aspartane, sugarcane
Sugar, cyclamate, enoxolone etc.；Correctives includes: sweeting agent and various essence；Preservative includes: parabens, benzoic acid,
Sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the eucalyptus oil of acetic acid chloroethene etc.；Substrate includes: PEG6000,
PEG4000, insect wax etc..
The present invention also provides for above-mentioned having the Chinese medicine composition of antitussive action, above-mentioned preparation method prepares only has
The preparation coughing the Chinese medicine composition of effect or the above-mentioned Chinese medicine composition with antitussive action has the medicine of antitussive action in preparation
Application in product or health product, application in the medicine of preparation treatment tracheitis, the medicine of preparation treatment pharyngolaryngitis or guarantor
Application in strong product, the application in the medicine or health product of preparation treatment asthma or treat tonsillitic medicine in preparation
Application in product or health product.
Compared with prior art, technical scheme has the advantage that
[Bulbus Lilii] property is put down, sweet in the mouth, and GUIXIN, through, lung meridian, has nourishing the lung to arrest cough, yin nourishing disappears heat, effect of clearing away heart-fire for tranquillization.
[Semen Sterculiae Lychnophorae] is cold in nature, sweet in the mouth, returns lung meridian, large intestine channel, has effect of clearing heat and moistening lung, liyan jiedu, loosening bowel to relieve constipation.
[Semen Raphani] property is put down, acrid in the mouth, sweet, returns spleen channel, stomach through, lung meridian, has effect of the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm.
[Semen Sinapis Albae] is warm in nature, and acrid in the mouth returns lung meridian, has warming the lung to eliminate phlegm, effect that promoting the circulation of QI eliminating stagnation, dredging collateral relieve the pain.
[Fructus Perillae] is warm in nature, acrid in the mouth, returns lung meridian, large intestine channel, has effect of relieving cough and asthma, loosening bowel to relieve constipation.
[Semen Armeniacae Amarum] slightly warm in nature, bitter in the mouth, return lung meridian, large intestine channel, there is effect of relieving cough and asthma, loosening bowel to relieve constipation.
[Folium Myricae rubrae] is warm in nature, bitter in the mouth, micro-pungent, have dampness, dispel the wind, antipruritic effect.
(1) Chinese medicine composition of the present invention, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine mutually it
Between proportioning, make each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", jointly act on, thus play cough-relieving and make
With；
(2) Chinese medicine composition of the present invention, only includes seven kinds of crude drug, and each crude drug is the most relatively conventional, easily obtain
Taking, composition is simple, cost is relatively low；
(3) diseases such as tracheitis, pharyngolaryngitis, asthma, tonsillitis are also had certain by Chinese medicine composition of the present invention
Therapeutical effect.
Detailed description of the invention
In following example of the present invention and experimental example, Bulbus Lilii, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae and Semen Armeniacae Amarum are
Commercially available product；Folium Myricae rubrae: the leaf of Myruca ceas plant Fructus Myricae rubrae, all can gather the whole year, generally gathers when cultivation training, using fresh herb or solarization
Dry.
Embodiment 1
The crude drug of the Chinese medicine composition that the present embodiment has antitussive action consists of: Bulbus Lilii 2g, Semen Sterculiae Lychnophorae 3g, Semen Raphani
2g, Semen Sinapis Albae 2g, Fructus Perillae 2g, Semen Armeniacae Amarum 3g, Folium Myricae rubrae 3g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, white
Semen Sinapis, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, grind after mixing or mixing, make 100 mesh powder after grinding, toasts at 150 DEG C
20min, to obtain final product.
Embodiment 2
The crude drug of the Chinese medicine composition that the present embodiment has antitussive action consists of: Bulbus Lilii 1g, Semen Sterculiae Lychnophorae 4.5g, Radix Raphani
Sub-1g, Semen Sinapis Albae 3g, Fructus Perillae 1g, Semen Armeniacae Amarum 4.5g, Folium Myricae rubrae 1.5g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, white
Semen Sinapis, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, heating and refluxing extraction 3 times, the water extraction of addition 3 weight times amount 2 hours, filter every time,
Merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The present embodiment has the Chinese medicine composition of antitussive action and adds customary adjuvant, according to common process, makes capsule.
Embodiment 3
The crude drug of the Chinese medicine composition that the present embodiment has antitussive action consists of: Bulbus Lilii 3g, Semen Sterculiae Lychnophorae 1.5g, Radix Raphani
Sub-3g, Semen Sinapis Albae 1g, Fructus Perillae 3g, Semen Armeniacae Amarum 1.5g, Folium Myricae rubrae 4.5g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, white
Semen Sinapis, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, heating and refluxing extraction 1 time, the water extraction of addition 5 weight times amount 1 hour, filters every time,
Merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The present embodiment has the Chinese medicine composition of antitussive action and adds customary adjuvant, according to common process, makes tablet.
Embodiment 4
The crude drug of the Chinese medicine composition that the present embodiment has antitussive action consists of: Bulbus Lilii 1.5g, Semen Sterculiae Lychnophorae 2.1g, Lay
Fu 1.7g, Semen Sinapis Albae 2.5g, Fructus Perillae 1.8g, Semen Armeniacae Amarum 3.0g, Folium Myricae rubrae 4.3g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, white
Semen Sinapis, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, heating and refluxing extraction 5 times, the water extraction of addition 1 weight times amount 3 hours, filter every time,
Merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The present embodiment has the Chinese medicine composition of antitussive action and adds customary adjuvant, according to common process, makes oral liquid.
Embodiment 5
The crude drug of the Chinese medicine composition that the present embodiment has antitussive action consists of: Bulbus Lilii 2g, Semen Sterculiae Lychnophorae 3g, Semen Raphani
2g, Semen Sinapis Albae 2g, Fructus Perillae 2g, Semen Armeniacae Amarum 3g, Folium Myricae rubrae 3g, 40 ° of China white wine 500mL；
The preparation method of this Chinese medicine composition, comprises the following steps:
Take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected body
40 ° of long-pending China white wines, airtight immersion 8 days under room temperature, filter, to obtain final product；Or
Take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected body
40 ° of long-pending China white wines, airtight dipping 2 times at 45 DEG C, every time dipping 3 days, cooling, filter, merge impregnation liquid, to obtain final product；Or
Person
Take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected body
40 ° of long-pending China white wines, micro-boiling is extracted 2 times, extracts 1.5 hours every time, and cooling is filtered, united extraction liquid, to be obtained final product.
Embodiment 6
The crude drug of the Chinese medicine composition that the present embodiment has antitussive action consists of: Bulbus Lilii 1.5g, Semen Sterculiae Lychnophorae 2.1g, Lay
Fu 1.7g, Semen Sinapis Albae 2.5g, Fructus Perillae 1.8g, Semen Armeniacae Amarum 3.0g, Folium Myricae rubrae 4.3g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, white
Semen Sinapis, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, grind after mixing or mixing, make 80 mesh powder after grinding, toasts at 170 DEG C
10min, to obtain final product.
Embodiment 7
The crude drug of the Chinese medicine composition that the present embodiment has antitussive action consists of: Bulbus Lilii 1g, Semen Sterculiae Lychnophorae 4.5g, Radix Raphani
Sub-1g, Semen Sinapis Albae 3g, Fructus Perillae 1g, Semen Armeniacae Amarum 4.5g, Folium Myricae rubrae 1.5g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Bulbus Lilii of selected weight, Semen Sterculiae Lychnophorae, Semen Raphani, white
Semen Sinapis, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, grind after mixing or mixing, make 120 mesh powder after grinding, toasts at 130 DEG C
30min, to obtain final product.
Experimental example 1The research of the cough-relieving curative effect of Chinese medicine composition of the present invention
1, experiment material
In this experimental example, each crude drug is commercially available product.
2, experimental technique
2.1 for reagent thing
Experimental group: the Chinese medicine composition of embodiment 1 preparation；Matched group: placebo.
2.2 experiment packets
Select in medical various cough patients 120 example in March, 2014 in February, 2015, patient age 18-68 year, flat
All 37.3 years old ages；All patients all get rid of the serious systemic diseases such as serious hepatorenal disease, malignant tumor.
Above-mentioned patient is randomly divided into experimental group and matched group, wherein experimental group 60 example, matched group 60 example, and two groups of patients are general
Data is not statistically significant (P ＞ 0.05) after statistical analysis, has comparability.
2.3 medication
Experimental group is administered orally the Chinese medicine composition of embodiment 1 preparation, each 0.6g, every day 2 times (early, evening each 1 time), takes continuously
Medicine 4 weeks；Matched group oral placebo, each 0.6g, every day 2 times (early, evening each 1 time), takes medicine 4 weeks continuously.
3, experimental data detection and process
After taking medicine 4 weeks, all patients are carried out the observation of cough clinical symptoms, it is judged that clinical efficacy.
Symptom assessment standard: (1) is effective: experimenter's clinical symptoms of coughing is wholly absent；(2) effective: experimenter's cough is faced
Bed symptom is obviously improved；(3) invalid: compared with before treatment, experimenter's clinical symptoms of coughing is unchanged or increase the weight of.Wherein, effective
Rate and effective percentage sum are referred to as total effective rate.
4, experimental result
The specific experiment result of experimental group and matched group is as shown in table 1.
The specific experiment result of 1 liang of table group patient
| Group | Number of cases | Effective number of cases | Effectively number of cases | Invalid number of cases | Total effective rate (%) |
| Experimental group | 60 | 40 | 16 | 4 | 93.3** |
| Matched group | 60 | 5 | 14 | 41 | 31.7 |
Note: compare with matched group,**P ＜ 0.01
As shown in Table 1, the total effective rate of experimental group is 93.3%, hence it is evident that be better than the total effective rate 31.7% of matched group；Two
The difference that group compares has statistical significance (P < 0.01).This shows, the Chinese medicine composition of embodiment 1 preparation can significantly improve
The total effective rate for the treatment of cough.
5, experiment conclusion
Chinese medicine composition of the present invention has significant therapeutic effect to cough, can be as the medicine of potential treatment cough
Thing.
Obviously, above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.Right
For those of ordinary skill in the field, can also make on the basis of the above description other multi-form change or
Variation.Here without also cannot all of embodiment be given exhaustive.And the obvious change thus extended out or
Change among still in the protection domain of the invention.
Claims (10)
1. a Chinese medicine composition, it is characterised in that its crude drug includes:
Bulbus Lilii 0.5～3.5 weight portion, Semen Sterculiae Lychnophorae 0.7～5.3 weight portion, Semen Raphani 0.5～3.5 weight portion, Semen Sinapis Albae 0.5～
3.5 weight portions, Fructus Perillae 0.5～3.5 weight portion, Semen Armeniacae Amarum 0.7～5.3 weight portion, Folium Myricae rubrae 0.7～5.3 weight portion.
Chinese medicine composition the most according to claim 1, it is characterised in that its crude drug includes:
Bulbus Lilii 1～3 weight portion, Semen Sterculiae Lychnophorae 1.5～4.5 weight portion, Semen Raphani 1～3 weight portion, Semen Sinapis Albae 1～3 weight portion, Soviet Union
Son 1～3 weight portions, Semen Armeniacae Amarum 1.5～4.5 weight portion, Folium Myricae rubrae 1.5～4.5 weight portion.
Chinese medicine composition the most according to claim 2, it is characterised in that its crude drug includes:
Bulbus Lilii 2 weight portion, Semen Sterculiae Lychnophorae 3 weight portion, Semen Raphani 2 weight portion, Semen Sinapis Albae 2 weight portion, Fructus Perillae 2 weight portion, Semen Armeniacae Amarum 3
Weight portion, Folium Myricae rubrae 3 weight portion；Or
Bulbus Lilii 1 weight portion, Semen Sterculiae Lychnophorae 4.5 weight portion, Semen Raphani 1 weight portion, Semen Sinapis Albae 3 weight portion, Fructus Perillae 1 weight portion, bitter Fructus Pruni
Core 4.5 weight portion, Folium Myricae rubrae 1.5 weight portion；Or
Bulbus Lilii 3 weight portion, Semen Sterculiae Lychnophorae 1.5 weight portion, Semen Raphani 3 weight portion, Semen Sinapis Albae 1 weight portion, Fructus Perillae 3 weight portion, bitter Fructus Pruni
Core 1.5 weight portion, Folium Myricae rubrae 4.5 weight portion；Or
Bulbus Lilii 1.5 weight portion, Semen Sterculiae Lychnophorae 2.1 weight portion, Semen Raphani 1.7 weight portion, Semen Sinapis Albae 2.5 weight portion, Fructus Perillae 1.8 weight
Part, Semen Armeniacae Amarum 3.0 weight portion, Folium Myricae rubrae 4.3 weight portion.
4. according to the Chinese medicine composition described in any one of claim 1-3, it is characterised in that also include Spirit 250～750 body
Long-pending part, described weight portion is g/mL with the relation of parts by volume.
5. the preparation method of the Chinese medicine composition described in an any one of claim 1-3, it is characterised in that include following step
Rapid:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, after grinding mixing or
Grind after mixing, make 50～150 mesh powder, toast at least 5min at 100～200 DEG C, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, heating and refluxing extraction
At least 1 time, the water extraction of addition at least 1 weight times amount at least 0.5 hour, filters, merging filtrate every time, is concentrated into 50 DEG C relatively
Density is 1.05-1.30, to obtain final product.
The preparation method of Chinese medicine composition the most according to claim 5, it is characterised in that comprise the following steps:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, after grinding mixing or
Grind after mixing, make 80～120 mesh powder, toast 10～30min at 130～170 DEG C, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, heating and refluxing extraction 1
～5 times, each water extraction 1 adding 1～5 weight times amount～3 hours, filter, merging filtrate, being concentrated into 50 DEG C of relative densities is
1.10-1.25, to obtain final product.
The preparation method of Chinese medicine composition the most according to claim 6, it is characterised in that comprise the following steps:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, after grinding mixing or
Grind after mixing, make 100 mesh powder, toast 20min at 150 DEG C, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, heating and refluxing extraction 3
Secondary, the water extraction of addition 3 weight times amount 2 hours, filter every time, and merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-
1.25, to obtain final product.
8. the preparation method of the Chinese medicine composition described in a claim 4, it is characterised in that comprise the following steps:
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected volume
Part Spirit, airtight immersion 7～10 days under room temperature, filter, to obtain final product；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected volume
Part Spirit, airtight dipping 1～3 times at 40～50 DEG C, every time dipping 1～5 day, cooling, filter, merge impregnation liquid, i.e.
?；Or
Take the Bulbus Lilii of selected weight portion, Semen Sterculiae Lychnophorae, Semen Raphani, Semen Sinapis Albae, Fructus Perillae, Semen Armeniacae Amarum and Folium Myricae rubrae, add selected volume
The Spirit of part, micro-boiling is extracted 1～4 time, extracts 1～3 hour every time, cooling, filtration, and united extraction liquid to obtain final product.
9. include the preparation of the Chinese medicine composition described in any one of claim 1-4 or include any one of claim 5-8 institute
The preparation of the Chinese medicine composition that the preparation method stated prepares, it is characterised in that
Described Chinese medicine composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule, dissipates
Agent, mixture, pill, granule, solution, syrup, soft extract, beverage, cookies, confection, cake or patch.
10. prepared by the Chinese medicine composition described in any one of claim 1-4, the preparation method described in any one of claim 5-8
The preparation of the Chinese medicine composition described in the Chinese medicine composition obtained or claim 9 preparation have antitussive action medicine or
Application in health product, application in the medicine of preparation treatment tracheitis, at the medicine of preparation treatment pharyngolaryngitis or health product
In application, application in the preparation treatment medicine of asthma or health product or preparation treat tonsillitic medicine or
Application in health product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610629591.8A CN106038975A (en) | 2016-08-01 | 2016-08-01 | Traditional Chinese medicine composition having function of suppressing cough and preparation method and application of traditional Chinese medicine composition |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610629591.8A CN106038975A (en) | 2016-08-01 | 2016-08-01 | Traditional Chinese medicine composition having function of suppressing cough and preparation method and application of traditional Chinese medicine composition |
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| CN201610629591.8A Pending CN106038975A (en) | 2016-08-01 | 2016-08-01 | Traditional Chinese medicine composition having function of suppressing cough and preparation method and application of traditional Chinese medicine composition |
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| CN106721740A (en) * | 2017-01-12 | 2017-05-31 | 广州仁惠经典网络科技有限公司 | Sweet basil drinks and preparation method thereof |
| CN107320709A (en) * | 2017-09-04 | 2017-11-07 | 上海市中医医院 | A kind of Chinese medicine composition for treating asthma in children |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106721740A (en) * | 2017-01-12 | 2017-05-31 | 广州仁惠经典网络科技有限公司 | Sweet basil drinks and preparation method thereof |
| CN107320709A (en) * | 2017-09-04 | 2017-11-07 | 上海市中医医院 | A kind of Chinese medicine composition for treating asthma in children |
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