CN104398912A - Medicine capable of moistening lung, relieving cough and reducing sputum and preparation method of medicine - Google Patents
Medicine capable of moistening lung, relieving cough and reducing sputum and preparation method of medicine Download PDFInfo
- Publication number
- CN104398912A CN104398912A CN201410703217.9A CN201410703217A CN104398912A CN 104398912 A CN104398912 A CN 104398912A CN 201410703217 A CN201410703217 A CN 201410703217A CN 104398912 A CN104398912 A CN 104398912A
- Authority
- CN
- China
- Prior art keywords
- medicine
- semen
- parched
- tablet
- relieving cough
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine capable of moistening lung, relieving cough and reducing sputum and a preparation method of the medicine. The medicine is prepared by mixing radix scutellariae, honey-made mulberry bark, flamed bitter apricot seeds, trichosanthes peel, fried waxgourd seeds, fried cassia seeds, herba ardisiae japonicae, fructus gardeniae praeparatus, rhizoma anemarrhenae, tendrilleaf fritillary bulb powder, cordate houttuynia, fried coix seeds and cortex magnoliae officinalis in parts by weight. The traditional Chinese medicine composition has the practical effect of treating cough, expectoration and blood-stained sputum caused by pneumonia, also has the effects of moistening lung, relieving cough, reducing sputum and treating pneumonia, and has no toxic or side effects.
Description
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to medicine of a kind of smoothing lung, relieving cough, eliminating phlegm and preparation method thereof specifically.
Background technology
The respiratory tract diseases such as tracheitis, pneumonia, bronchiectasis are more common in cough, abundant expectoration.Part patients with pneumonia there will be heating, cough, expectoration, sputum mixed with blood, can accompany the clinical symptoms such as chest pain or dyspnea.The cough caused for bacterial pneumonia, abundant expectoration, adopt antibiotic therapy, can cure more than 7 ~ 10 days.And the state of an illness of viral pneumonia, use antibiotic therapy invalid.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes medicine of a kind of smoothing lung, relieving cough, eliminating phlegm and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Scutellariae 5-15g, honey-made mulberry bark 7-17g, Semen Armeniacae Amarum (blanched in boiling water) 5-15g, Pericarpium Trichosanthis 7-17g, stir-fry Semen Benincasae 5-15g, Semen Cassiae (parched) 5-15g, Herba Ardisiae Japonicae 5-15g, Fructus Gardeniae Preparatus 7-17g, Rhizoma Anemarrhenae 5-15g, Bulbus Fritillariae Cirrhosae powder 3-8g, Herba Houttuyniae 10-20g, Semen Coicis (parched) 10-20g, Cortex Magnoliae Officinalis(processed with ginger) 5-15g.Optimum ratio is: Radix Scutellariae 10g, honey-made mulberry bark 12g, Semen Armeniacae Amarum (blanched in boiling water) 10g, Pericarpium Trichosanthis 12g, stir-fry Semen Benincasae 10g, Semen Cassiae (parched) 10g, Herba Ardisiae Japonicae 10g, Fructus Gardeniae Preparatus 12g, Rhizoma Anemarrhenae 10g, Bulbus Fritillariae Cirrhosae powder 5g, Herba Houttuyniae 15g, Semen Coicis (parched) 15g, Cortex Magnoliae Officinalis(processed with ginger) 10g.Described medicament is decoction, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Scutellariae, honey-made mulberry bark, Semen Armeniacae Amarum (blanched in boiling water), Pericarpium Trichosanthis, stir-fry Semen Benincasae, Semen Cassiae (parched), Herba Ardisiae Japonicae, Fructus Gardeniae Preparatus, the Rhizoma Anemarrhenae, Bulbus Fritillariae Cirrhosae powder, Herba Houttuyniae, Semen Coicis (parched), Cortex Magnoliae Officinalis(processed with ginger) pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
Radix Scutellariae: bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical antibiotic property of Radix Scutellariae is better than Rhizoma Coptidis, and does not develop immunity to drugs.
Honey-made mulberry bark: modern medicine confirms, (1) has diuresis Cortex Mori decoct 2g/kg, to rabbit, oral or Cortex Mori aqueous extract and n-butanol extract 300 ~ 500mg/kg, to Oral Administration in Rats or lumbar injection, all have significant diuresis.(Na, K output in 6 hours, all significantly increases to make urine volume and the chloride in urinating.There is significant diuresis.(2) there is antiinflammatory action Cortex Mori water extract and have inhibitory action to the swollen feet caused by Oral Administration in Rats or injection on Carrageenan and glucosan.(3) there is antibacterial action Cortex Mori decoct and have stronger inhibitory action to staphylococcus aureus; Also slight inhibitory action is had to Bacillus typhi and shigella flexneri.Cortex Mori furan A all has stronger bacteriostatic activity to staphylococcus aureus, mycobacterium.Cyclomorusin also has antifungic action.
Semen Armeniacae Amarum (blanched in boiling water): Semen Armeniacae Amarum (blanched in boiling water) concocts a kind of method of medical material, steaming and decocting Dan method not only used fire with water, belonged to water and fire a total system.Steaming method and cooking method are used for the process of preparing Chinese medicine that some have tonic effect or toxic side effect medicine, and its tonic effect can be made after system to strengthen, and toxic and side effects reduces.Dan method is applicable to the kind subclass medicine that must remove the peel, and is convenient to be separated seed coat and kernel after system.Semen Armeniacae Amarum has following functions: (1) has antitussive, antiasthmatic effect.Containing amygdaloside in Semen Armeniacae Amarum, amygdaloside can be hydrolyzed by the emulsin contained by enteric microorganism enzyme or Semen Armeniacae Amarum itself in vivo, produces hydrocyanic acid and the benzaldehyde of trace, has inhibitory action, reach antitussive, antiasthmatic effect to respiratory center." book on Chinese herbal medicine is looked for the truth " records " Semen Armeniacae Amarum, the energy of existing dispersing wind-cold have the therapeutic method to keep the adverse QI flowing downwards to remove the power of breathing heavily again ".Kind relieving cough and resolving phlegm and relievining asthma, to chief complaint cough, the abundant expectoration of lung system, pants and have strong specific aim, therefore doctor it can be used as the medication use of lung system at all times, no matter internal injury diseases caused by exogenous pathogenic factor, new sick obstinate disease, all lungs that relate to, multiplex it.Adopt the test of guinea pig in vitro organ, almond water extracting solution can reduce the sensitivity that organ irritates ammonia, to antihistamine, acetylcholine, barium chloride to the excitation of tracheal smooth muscle, has obvious antitussive action.Adopt SO2 to cause the method for coughing to prove, after keeping 30min to mouse stomach amygdaloside 1mg/kg, 10mg/kg, 100mg/kg, it is respectively 26%, 22.8%, 25.3% to the suppression ratio of cough frequency.The effect of gavage Semen Armeniacae Amarum extract 48.3mg/kg is stronger than equivalent amygdaloside by 39.7%.Semen Armeniacae Amarum is conducive to pulmonary respiratory function because promoting the synthesis of pulmonary surfactant (PS), Semen Armeniacae Amarum can not only promote the synthesis of PS, and can improve the various physiology and biochemistry index about lung (as total phospholipids and pathological section etc. in lung homogenate, edema caused by the lung disorder amount, bronchial lavage).(2) there is antiinflammatory, analgesic activity.The amygdalate water extract of defat to caused by acetic acid mouse writhing reaction and cotton balls caused by rat granulomatous inflammation be formed with inhibitory action.By rat joints of foot edema method, during water soluble protein composition KR-A, KR-B5mg/kg of intravenous injection 40mg/kg Semen Armeniacae Amarum, there is inflammation-inhibiting effect.Show by mice naphthoquinone induced pain model test, during KR-A or KR-B intravenously administrable 5mg/kg, press down pain rate and be respectively 40.7% and 58.2%.They are swollen to Rat Carrageenan colloidality foot, and the ED50 of oral uptake is respectively 13.9mg/kg and 6.4mg/kg.Hot plate method in mice and acetic acid writhing method confirm, amygdaloside has analgesic activity, but is different from the analgesics of morphine.Amygdaloside decomposes the benzaldehyde quiet Benzoinum condensing enzyme effect produced and generates Benzoinum.Benzoinum has analgesic activity, and therefore the domestic people of having can remove the misery of patient with Semen Armeniacae Amarum treatment advanced liver cancer, and even not needing of having takes analgesic.
Pericarpium Trichosanthis: [function cures mainly] moistening the lung and resolving phlegm, promoting the circulation of QI the chest stuffiness relieving.Control phlegm-heat cough, pharyngalgia, chest pain, spit blood, epistaxis, quenches one's thirst, constipation, carbuncle pyogenic infections from tumour or sore.
Fry Semen Benincasae: [function cures mainly] moistening the lung and resolving phlegm, diuretic.Control phlegm-heat cough, lung abscess, acute appendicitis, gonorrhea, edema, beriberi, hemorrhoid, nasal surface wine Zha
Semen Cassiae (parched): Semen Cassiae is also named that Semen Cassiae, sheep are bright, Cornu Caprae seu Ovis, Horse hoof Semen Cassiae, go back gb 1, bullshit bean, false Semen phaseoli radiati, Horse hoof, Herba Senecionis Scandentis, celery certainly, swordweed, wild Semen phaseoli radiati, Os Sus domestica bright, the blue bean of pig dung, spire Herba crotalariae mucronatae, night rock, sheep tail bean.Bitter in the mouth, sweet and cool in nature, there is the functions such as clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight.
Herba Ardisiae Japonicae: [meridian distribution of property and flavor] property is put down, acrid in the mouth, micro-hardship.Return lung, Liver Channel.[function cures mainly] preventing phlegm from forming and stopping coughing, dampness removing, invigorates blood circulation.For cough, sputum mixed with blood, chronic bronchitis, jaundice due to damp-heat, injury from falling down.
Fructus Gardeniae Preparatus: [meridian distribution of property and flavor] is bitter, cold.GUIXIN, lung, tri-jiao channel.[function cures mainly] cooling blood for hemostasis.Nosebleed is told, hematuria metrorrhagia for heat in blood.
The Rhizoma Anemarrhenae: property bitter cold, has nourishing YIN to lower pathogenic fire, moisturizes laxation, the effect of sharp defecation.Gunpowder under genus heat clearing away, cures mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.
Bulbus Fritillariae Cirrhosae powder: [nature and flavor] are cool in nature, Gan Ping.[return through] enters lung meridian, stomach warp.The resolving phlegm and relieving asthma of [effect] nourishing the lung to arrest cough, removing heat-phlegm.
Herba Houttuyniae: acrid in the mouth, cold, return lung meridian.Heat-clearing and toxic substances removing, detumescence can treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion, by the lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. of controlling excess-heat, pyretic toxicity, damp, disease heat are trouble.Modern pharmacology experiment shows, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Control viral pneumonia, bronchitis; Control lung abscess vomiting pus to spit blood.
Semen Coicis (parched): Semen Coicis, Chinese medicine, another name Semen Coicis, NLIUGU, Semen Coicis, the Fructus Sapindi Mukouossi.Nature and flavor are cool in nature, sweet in the mouth, light.There is spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal.For effect of edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen.Cure mainly: consumptive lung disease is coughed, and has pus and blood.The excessively inclined property of parching to brown energy obtundent, the fragrance simultaneously distributed, the effect of resolving depression of regulating the flow of vital energy in addition.
Cortex Magnoliae Officinalis(processed with ginger): return spleen, lung, stomach, large intestine channel.[function cures mainly] alleviating distention in middle-JIAO is regulated the flow of vital energy, and removing dampness dissipating depression of QI, removing food stagnancy is relievingd asthma.
The present invention is with Herba Houttuyniae, Semen Coicis (parched) for monarch drug, and treatment excess-heat, pyretic toxicity, damp, disease heat are lung abscess, the sore swollen toxin of suffering from, treatment viral pneumonia, and treatment lung abscess vomiting pus is spitted blood, and consumptive lung disease is coughed.
With honey-made mulberry bark, Pericarpium Trichosanthis, Fructus Gardeniae Preparatus for ministerial drug, antimicrobial antiphlogistic, moistening the lung and resolving phlegm, promoting the circulation of QI the chest stuffiness relieving, cooling blood for hemostasis.
Assistant makes with Radix Scutellariae, Semen Armeniacae Amarum (blanched in boiling water), stir-fry Semen Benincasae, Semen Cassiae (parched), Herba Ardisiae Japonicae, the Rhizoma Anemarrhenae, Cortex Magnoliae Officinalis(processed with ginger), Bulbus Fritillariae Cirrhosae powder, heat clearing and damp drying, eliminating fire and detoxication, moistening the lung and resolving phlegm, relieving cough and asthma.
Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
beneficial effect
The cough that Chinese medicine composition of the present invention causes treatment pneumonia, expectoration, sputum mixed with blood have practical curative effect, have effect of smoothing lung, relieving cough, eliminating phlegm, treatment pneumonia.And have no side effect.
medicine for a better understanding of the present invention, first by as follows for clinical data statistics:
case is screened
In June ,-2014 in 2012, acute pulmonary abscess patient, patients with pneumonia, clinical symptoms is: thick sputum, cough, expectoration, sputum mixed with blood, applies patient 187 example of Drug therapy of the present invention.
diagnostic method
Blood routine examination;
Sputum culturing;
X-ray chest film inspection;
Clinical symptoms: heating, cough, expectoration, sputum mixed with blood, can accompany chest pain or dyspnea.
therapeutic Method
Medicine decoction of the present invention, every day potion, sooner or later twice decoction 10 days is a course for the treatment of.
the standard of curative effect evaluation
Cure: symptom, sign disappear completely;
Effective: symptom obviously alleviates, sign is clearly better;
Invalid: symptom, sign without being clearly better, or increase the weight of;
Total effective rate=cure rate+effective percentage.
statistical result
Case load | Cure | Effectively | Invalid | Cure rate | Total effective rate |
187 | 165 | 20 | 2 | 88.24% | 98.93% |
conclusion
Pass through in June ,-2014 in 2012, acute pulmonary abscess patient, patients with pneumonia, clinical symptoms is: thick sputum, cough, expectoration, sputum mixed with blood, and the 187 routine patient's curative effects applying Drug therapy of the present invention are added up, and cures 165 examples, cure rate reaches 88.24%, effective 20 examples, invalid 2 examples, total effective rate reaches 98.93%.
Clinical trial for many years and use, the cough that medicine of the present invention causes treatment pneumonia, chronic obstructive pulmonary disease, pulmonary tuberculosis, pulmonary carcinoma acute and chronic respiratory tract disease, abundant expectoration, thick sputum, sputum mixed with blood have remarkable contribution, and have no side effect.
Acute toxicity test: larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
Detailed description of the invention
embodiment 1:medicine of a kind of smoothing lung, relieving cough, eliminating phlegm and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Scutellariae 5-15g, honey-made mulberry bark 7-17g, Semen Armeniacae Amarum (blanched in boiling water) 5-15g, Pericarpium Trichosanthis 7-17g, stir-fry Semen Benincasae 5-15g, Semen Cassiae (parched) 5-15g, Herba Ardisiae Japonicae 5-15g, Fructus Gardeniae Preparatus 7-17g, Rhizoma Anemarrhenae 5-15g, Bulbus Fritillariae Cirrhosae powder 3-8g, Herba Houttuyniae 10-20g, Semen Coicis (parched) 10-20g, Cortex Magnoliae Officinalis(processed with ginger) 5-15g.Described medicament is decoction, capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Radix Scutellariae 5-15g, honey-made mulberry bark 7-17g, Semen Armeniacae Amarum (blanched in boiling water) 5-15g, Pericarpium Trichosanthis 7-17g, stir-fry Semen Benincasae 5-15g, Semen Cassiae (parched) 5-15g, Herba Ardisiae Japonicae 5-15g, Fructus Gardeniae Preparatus 7-17g, Rhizoma Anemarrhenae 5-15g, Bulbus Fritillariae Cirrhosae powder 3-8g, Herba Houttuyniae 10-20g, Semen Coicis (parched) 10-20g, Cortex Magnoliae Officinalis(processed with ginger) 5-15g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Scutellariae, honey-made mulberry bark, Semen Armeniacae Amarum (blanched in boiling water), Pericarpium Trichosanthis, stir-fry Semen Benincasae, Semen Cassiae (parched), Herba Ardisiae Japonicae, Fructus Gardeniae Preparatus, the Rhizoma Anemarrhenae, Bulbus Fritillariae Cirrhosae powder, Herba Houttuyniae, Semen Coicis (parched), Cortex Magnoliae Officinalis(processed with ginger) pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Described decoction clear water decocts, under after Bulbus Fritillariae Cirrhosae powder.
embodiment 2:medicine of a kind of smoothing lung, relieving cough, eliminating phlegm and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Scutellariae 10g, honey-made mulberry bark 12g, Semen Armeniacae Amarum (blanched in boiling water) 10g, Pericarpium Trichosanthis 12g, stir-fry Semen Benincasae 10g, Semen Cassiae (parched) 10g, Herba Ardisiae Japonicae 10g, Fructus Gardeniae Preparatus 12g, Rhizoma Anemarrhenae 10g, Bulbus Fritillariae Cirrhosae powder 5g, Herba Houttuyniae 15g, Semen Coicis (parched) 15g, Cortex Magnoliae Officinalis(processed with ginger) 10g.Described medicament is decoction, capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Radix Scutellariae 10g, honey-made mulberry bark 12g, Semen Armeniacae Amarum (blanched in boiling water) 10g, Pericarpium Trichosanthis 12g, stir-fry Semen Benincasae 10g, Semen Cassiae (parched) 10g, Herba Ardisiae Japonicae 10g, Fructus Gardeniae Preparatus 12g, Rhizoma Anemarrhenae 10g, Bulbus Fritillariae Cirrhosae powder 5g, Herba Houttuyniae 15g, Semen Coicis (parched) 15g, Cortex Magnoliae Officinalis(processed with ginger) 10g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Scutellariae, honey-made mulberry bark, Semen Armeniacae Amarum (blanched in boiling water), Pericarpium Trichosanthis, stir-fry Semen Benincasae, Semen Cassiae (parched), Herba Ardisiae Japonicae, Fructus Gardeniae Preparatus, the Rhizoma Anemarrhenae, Bulbus Fritillariae Cirrhosae powder, Herba Houttuyniae, Semen Coicis (parched), Cortex Magnoliae Officinalis(processed with ginger) pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Described decoction clear water decocts, under after Bulbus Fritillariae Cirrhosae powder.
Embodiment 3: medicine of the present invention can also be oral liquid, granule etc.
Claims (5)
1. a medicine for smoothing lung, relieving cough, eliminating phlegm, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Scutellariae 5-15g, honey-made mulberry bark 7-17g, Semen Armeniacae Amarum (blanched in boiling water) 5-15g, Pericarpium Trichosanthis 7-17g, stir-fry Semen Benincasae 5-15g, Semen Cassiae (parched) 5-15g, Herba Ardisiae Japonicae 5-15g, Fructus Gardeniae Preparatus 7-17g, Rhizoma Anemarrhenae 5-15g, Bulbus Fritillariae Cirrhosae powder 3-8g, Herba Houttuyniae 10-20g, Semen Coicis (parched) 10-20g, Cortex Magnoliae Officinalis(processed with ginger) 5-15g.
2. the medicine of smoothing lung, relieving cough, eliminating phlegm according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Scutellariae 10g, honey-made mulberry bark 12g, Semen Armeniacae Amarum (blanched in boiling water) 10g, Pericarpium Trichosanthis 12g, stir-fry Semen Benincasae 10g, Semen Cassiae (parched) 10g, Herba Ardisiae Japonicae 10g, Fructus Gardeniae Preparatus 12g, Rhizoma Anemarrhenae 10g, Bulbus Fritillariae Cirrhosae powder 5g, Herba Houttuyniae 15g, Semen Coicis (parched) 15g, Cortex Magnoliae Officinalis(processed with ginger) 10g.
3. the medicine of smoothing lung, relieving cough, eliminating phlegm according to claim 1 and 2, is characterized in that: described medicament is decoction, capsule, tablet or pill.
4. the medicine of smoothing lung, relieving cough, eliminating phlegm according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Scutellariae, honey-made mulberry bark, Semen Armeniacae Amarum (blanched in boiling water), Pericarpium Trichosanthis, stir-fry Semen Benincasae, Semen Cassiae (parched), Herba Ardisiae Japonicae, Fructus Gardeniae Preparatus, the Rhizoma Anemarrhenae, Bulbus Fritillariae Cirrhosae powder, Herba Houttuyniae, Semen Coicis (parched), Cortex Magnoliae Officinalis(processed with ginger) pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine of smoothing lung, relieving cough, eliminating phlegm according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410703217.9A CN104398912A (en) | 2014-11-29 | 2014-11-29 | Medicine capable of moistening lung, relieving cough and reducing sputum and preparation method of medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410703217.9A CN104398912A (en) | 2014-11-29 | 2014-11-29 | Medicine capable of moistening lung, relieving cough and reducing sputum and preparation method of medicine |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104398912A true CN104398912A (en) | 2015-03-11 |
Family
ID=52636621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410703217.9A Pending CN104398912A (en) | 2014-11-29 | 2014-11-29 | Medicine capable of moistening lung, relieving cough and reducing sputum and preparation method of medicine |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104398912A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105030992A (en) * | 2015-08-26 | 2015-11-11 | 唐媚英 | Traditional Chinese medicine preparation for treating cough and preparation method thereof |
CN107296928A (en) * | 2017-06-30 | 2017-10-27 | 成都恒凌科技有限公司 | A kind of paste and application thereof |
CN114732070A (en) * | 2022-05-16 | 2022-07-12 | 昆明理工大学 | Functional herbal tea capable of relieving cough and reducing sputum and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103417875A (en) * | 2013-09-09 | 2013-12-04 | 张建怀 | Traditional Chinese medicine preparation for treating chronic bronchitis and preparing method thereof |
-
2014
- 2014-11-29 CN CN201410703217.9A patent/CN104398912A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103417875A (en) * | 2013-09-09 | 2013-12-04 | 张建怀 | Traditional Chinese medicine preparation for treating chronic bronchitis and preparing method thereof |
Non-Patent Citations (2)
Title |
---|
沈湘妹等: "苇茎汤加味治疗小儿过敏性咳嗽60例", 《辽宁中医杂志》 * |
霍光磊: "浅谈冬春季时行感冒的治疗体会", 《新疆中医药》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105030992A (en) * | 2015-08-26 | 2015-11-11 | 唐媚英 | Traditional Chinese medicine preparation for treating cough and preparation method thereof |
CN107296928A (en) * | 2017-06-30 | 2017-10-27 | 成都恒凌科技有限公司 | A kind of paste and application thereof |
CN114732070A (en) * | 2022-05-16 | 2022-07-12 | 昆明理工大学 | Functional herbal tea capable of relieving cough and reducing sputum and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100404067C (en) | Traditional medicine preparation for treating children's pulmonary disease | |
CN101972338B (en) | Chinese medicinal preparation for treating infantile upper respiratory tract infection and preparation method thereof | |
CN104173937A (en) | Traditional Chinese medicine composition for dispersing stagnated liver qi for promoting bile flow and applications thereof | |
CN104398912A (en) | Medicine capable of moistening lung, relieving cough and reducing sputum and preparation method of medicine | |
CN106606719A (en) | Traditional Chinese medicine used for treating chronic cough | |
CN104758900A (en) | Traditional Chinese medicine for treating acute pancreatitis | |
CN103599362A (en) | Traditional Chinese medicine composition for treating swine enzootic pneumonia and preparation method thereof | |
CN103055218A (en) | Traditional Chinese medicine composition for treating neonatal jaundice and preparation method thereof | |
CN102727738A (en) | Traditional Chinese medicine composition used for treating chronic obstructive pulmonary disease, and preparation method thereof | |
CN105999092A (en) | Traditional Chinese medicine pill for treating melanosis coli | |
CN104399040A (en) | Drug for treating gastrectasia and preparation method thereof | |
CN104906472A (en) | Traditional Chinese medicine composition for preventing and treating cough-variant asthma | |
CN103860844B (en) | A kind of Chinese medicine preparation for the treatment of chronic colitis and preparation method thereof | |
CN103656459B (en) | A kind of Chinese medicine for the treatment of deficiency of both lung and spleen syndrome cough | |
CN116549595B (en) | Pharmaceutical composition for treating functional dyspepsia of children, preparation and application thereof | |
CN103007202A (en) | Traditional Chinese medicine composition for treating pancreatic cancer | |
CN1222364A (en) | Serial medicines for curing cancer through oral taking, dressing and medicated diet and preparation thereof | |
CN102755575B (en) | Radix asparagi, fructus trichosanthis and pepperweed seed powder for infant pertussis syndrome | |
CN102166300B (en) | Traditional Chinese medicine preparation for treating pulmonary yin deficiency, gastric yin deficiency and diabetic yin deficiency | |
CN100540033C (en) | A kind of externally-applied health-care products that is used for hepatitis B recuperating medicine and preparation method thereof | |
CN106620266A (en) | Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine | |
CN104491571A (en) | Medicament for treating throat pain and thirst and preparation method thereof | |
CN105168847A (en) | Traditional Chinese medicine for treating helicobacter pylori infected peptic ulcer | |
CN104398889A (en) | Traditional Chinese medicine composition capable of expelling phlegm and arresting coughing and preparation method of traditional Chinese medicine composition | |
CN103800742A (en) | Acne removing composition prepared from medicine-food homologous medicinal materials fully |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150311 |