CN104491571A - Medicament for treating throat pain and thirst and preparation method thereof - Google Patents

Medicament for treating throat pain and thirst and preparation method thereof Download PDF

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CN104491571A
CN104491571A CN201410703229.1A CN201410703229A CN104491571A CN 104491571 A CN104491571 A CN 104491571A CN 201410703229 A CN201410703229 A CN 201410703229A CN 104491571 A CN104491571 A CN 104491571A
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radix
tablet
medicament
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pill
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高春娟
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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Abstract

The invention provides a medicament for treating throat pain and thirst and a preparation method. The medicament is prepared from codonopsis pilosula, largehead atractylodes rhizome, tuckahoe, dried tangerine peel, Chinese yam, raw coix seed, fried rice sprout, day lily, divaricate saposhnikovia root, rehmannia root, figwort root, cicada slough and siberian cocklour fruit by combination. The medicament has effects of strengthening the spleen and tonifying the lung, detoxifying and removing stasis, relieving stuffy noses, expelling wind-damp, stopping bleeding and relieving restlessness, and driving away thirst, has a significant effect on treating thirst and throat pain caused by cold fever, and does not have side effects.

Description

A kind for the treatment of is had sore throat, the medicine of xerostomia and preparation method thereof
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relate to specifically a kind of treat anemopyretic cold cause have sore throat, the medicine of xerostomia and preparation method thereof.
Background technology
Having sore throat is a kind of modal disease, and it is mainly in the cold season in 1 year, and flu, tonsillitis, sinusitis, pertussis, pharyngolaryngitis and viral infection even myocardial infarction all can cause throat pain.The material of any stimulation throat and oral mucosa all may cause throat pain.They comprise: virus, bacteriological infection, anaphylaxis, dust, medicated cigarette, waste gas, hot beverage or food, tooth or gingival infection also can involve throat sometimes, chronic cough, bone-dry environment, gastroesophageal reflux and sound of speaking are excessive can stimulate throat equally, and hoarseness is common simultaneous phenomenon.Occur that the common disease of throat pain symptom has: systemic viral infection, parotitis, pharyngitis or tonsillitis, pharyngolaryngitis and flu.The throat pain simultaneous phenomenon that different pathogeny causes is not identical yet.
Respiratory tract infection is called for short upper sense, also known as common cold.It is the general name comprising nasal cavity, pharynx or acute throat inflammation.The upper sense of broad sense is not a medical diagnosis on disease, but one group of disease, comprise common cold, viral pharyngitis, laryngitis, herpangina, pharyngoconjunctival fever, bacterial pharyngotonsillitis.The upper sense of narrow sense, also known as common cold, is modal acute infections of respiratory tract disease, and how in self limiting, but incidence rate is higher.Adult is annual to be occurred 2 ~ 4 times, and child's incidence rate is higher, annual 6 ~ 8 times.The whole year all can fall ill, and winter-spring season is more.
Flu is divided into the types such as wind and cold, wind heat, heat-damp in summer, exterior cold and interior heat on tcm clinical practice.Anemopyretic cold main manifestations is the yellow sticky nasal mucus of stream, and obviously, even have high heat, perspiration, throat pain, cough, expectorant Huang thick, tongue fur is BOHUANG color, xerostomia in heating.
Caused by the traditional Chinese medical science thinks that anemopyretic cold is the evil criminal table of wind heat, lung qi is become estranged.Symptoms is heating weight, micro evil wind, distending pain in the head, have antiperspirant, red swelling and pain of throat, cough, expectorant are glutinous or yellow, yellow thick nasal discharge of having a stuffy nose, thirst and liking drink, the tip of the tongue limit are red, the micro-Huang of white and thin fur.Anemopyretic cold is more common in summer and autumn, caused by affection due to external wind and heat.The traditional Chinese medical science is thought, anemopyretic cold is the exterior syndrome caused by heresy experiencing wind heat.
At present, what western medicine flu caused has sore throat mainly with antiinflammatory, antibiotics treatment, but antiinflammatory, antibiolics class can only be taken stopgap measures and can not be effected a permanent cure, and side effect is larger.Chinese medicine is free from side effects substantially, but curative effect is slow.For many years, doctors are exploring curative effect Traditional Chinese medicinal prescription faster always, with the treatment of symptom of accelerating to have sore throat.
Summary of the invention
The present invention from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, propose a kind of cure mainly anemopyretic cold cause have sore throat, the medicine of xerostomia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Codonopsis 5-15g, Rhizoma Atractylodis Macrocephalae 5-15g, Poria 5-15g, Pericarpium Citri Reticulatae 5-15g, Rhizoma Dioscoreae 5-15g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 5-15g, Hemerocallis citrina Baroni 5-15g, Radix Saposhnikoviae 3-10g, Radix Rehmanniae 5-15g, Radix Scrophulariae 8-17g, Periostracum Cicadae 3-10g, Fructus Xanthii 5-15g.Optimum ratio is: Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Dioscoreae 10g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 10g, Hemerocallis citrina Baroni 10g, Radix Saposhnikoviae 5g, Radix Rehmanniae 10g, Radix Scrophulariae 12g, Periostracum Cicadae 5g, Fructus Xanthii 10g.Described medicament is decoction, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Semen Coicis, Fructus Setariae Germinatus (parched), Hemerocallis citrina Baroni, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Scrophulariae, Periostracum Cicadae, Fructus Xanthii pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
Radix Codonopsis: Radix Codonopsis is put down, sweet in the mouth, there is effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, body immunity can also be strengthened, improve the activity of superoxide dismutase, strengthen the ability eliminating free radical, there is the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.Be applicable to deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency, interior-heat such as to quench one's thirst at the disease.Energy lung heat clearing gold, invigorating primordial QI, opens sound, helps biceps, and supplementing QI for promoting the production of body fluid controls calentura thirsty, dry mouth and tougue.
The Rhizoma Atractylodis Macrocephalae: there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Poria: have promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves, for cough due to fluid-retention, phlegm-damp enters network, aching pain in should and back.
Pericarpium Citri Reticulatae: there is regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm effect, for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Dioscoreae: return spleen, lung, kidney channel; Have spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission effect, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.
Semen Coicis: Semen Coicis is the kernel of grass Semen Coicis, according to different body constitution needs, as cold body or fiery body, Semen Coicis concocts into Semen Coicis and ripe Semen Coicis.Enter spleen, lung, kidney channel.There is effect of spleen invigorating, tonifying the lung, heat clearing away, dampness removing." not Lu ": except muscles and bones pathogen is meciless, sharp the intestines and stomach, consumer edema, makes us eating.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
Fructus Setariae Germinatus (parched): there is spleen benefiting and stimulating the appetite, and in help digestion effect, control indigestion, distension, have loose bowels.
Hemerocallis citrina Baroni: property is flat, sweet in the mouth, micro-hardship, returns liver,spleen,kidney warp; Have clearing away heat and promoting diuresis, removing toxic substances and promoting subsidence of swelling, hemostasis relieving restlessness, the chest stuffiness relieving diaphragm, nourish blood suppressing the hyperactive liver, diuretic lactogenesis, sore-throat relieving the chest stuffiness relieving, eliminating damp-heat, the effect such as to stimulate the secretion of milk; Cure mainly the diseases such as vertigo and tinnitus, cardiopalmus unhappiness, hot urination, edema, hemorrhoidal hemorrhage.
Radix Saposhnikoviae: return urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.There is Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, itching-relieving efficacies, cure mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus.
The Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.There is clearing away heat and cooling blood effect to join the army blood for warm febrile disease, high fever coma, xerostomia crimson tongue.
Radix Scrophulariae: clearing away heat and cooling blood; Nourishing YIN to lower pathogenic fire; Detoxicating and resolving stagnation of pathogens.Main warm febrile disease and nutrient blood; Fever of the body; Excessive thirst; Crimson tongue; Send out speckle; Hectic fever due to YIN-deficiency chronic cough; Fidgets due to deficiency is awake not; Constipation is hindered in Tianjin; Order is puckery dim-sighted; Throat larynx swells and ache; Scrofula sucutaneous nodule; Skin sore.
Periostracum Cicadae: loose wind heat, lung qi dispersing, determines convulsion.Control affection due to external wind and heat, cough hoarseness, measles is sent out not smooth thoroughly, rubella pruritus, pediatric epilepsy scared, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.
Fructus Xanthii: return lung, Liver Channel.There is dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, analgesic efficacy, for anemofrigid cold, nasal sinusitis, rheumatic arthralgia, the cards such as rubella pruritus.
The traditional Chinese medical science is thought, caused by anemopyretic cold is the evil criminal table of wind heat, lung qi is become estranged, has sore throat, the cardinal symptom of xerostomia anemopyretic cold, and mainly anemopyretic cold fever dissipation body fluid, lack of lung-YIN, the blockage of main and collateral channels of throat, caused by blood circulation is bad.Therefore, the present invention with Semen Coicis, Radix Scrophulariae for monarch drug, strengthening the spleen and tonifying the lung, clearing away heat-damp and promoting diuresis, clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens.With Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Setariae Germinatus (parched), Hemerocallis citrina Baroni, the Radix Rehmanniae, Fructus Xanthii for ministerial drug, invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, invigorating the spleen and benefiting QI, dampness diuretic, promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing, regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, spleen benefiting and stimulating the appetite, and in help digestion, clearing away heat and promoting diuresis, removing toxic substances and promoting subsidence of swelling, hemostasis relieving restlessness, the chest stuffiness relieving diaphragm, nourish blood suppressing the hyperactive liver, clearing away heat and cooling blood, dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving.Assistant makes with Radix Saposhnikoviae, Periostracum Cicadae, and expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic are antipruritic, and loose wind heat, lung qi dispersing determines convulsion.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
beneficial effect
Chinese medicine composition of the present invention can strengthening the spleen and tonifying the lung, detoxicating and resolving stagnation of pathogens, clearing the nasal passage, wind-damp dispelling, hemostasis relieving restlessness, xerostomia of dispelling, and to treatment because the xerostomia that causes of cat fever, has sore throat evident in efficacy, and has no side effect.
non-clinical statistical data
1, case selection
Anemopyretic cold patient 56 example.
2, diagnostic criteria
Anemopyretic cold: heating weight, micro evil wind, distending pain in the head, have that antiperspirant, red swelling and pain of throat, cough, expectorant are glutinous or yellow, yellow thick nasal discharge of having a stuffy nose, thirst and liking drink, the tip of the tongue limit are red, the micro-Huang of white and thin fur.
3, therapeutic scheme
The made capsule of embodiment 2, the morning, noon and afternoon each 4 after meal, every 0.3g, 4 days is a course for the treatment of, adds up after 2 courses for the treatment of.
4, the standard of curative effect evaluation
Cure: body temperature is normal, red swelling and pain of throat disappears, and sputum is normal, and tongue fur is ruddy;
Effective: body temperature is normal, and red swelling and pain of throat slows down, and xerostomia slows down;
Invalid: symptom without significant change, or increases the weight of;
Total effective rate=cure rate+effective percentage.
5, data statistics
Case load Cure Effectively Invalid Cure rate Total effective rate
56 47 8 1 83.93% 98.21%
6, select anemopyretic cold patient 56 example according to diagnostic criteria, according to therapeutic scheme, test of cure is carried out to this 56 routine patient, according to the standard of curative effect evaluation, obtain result as follows, 56 routine patients, cure 42 examples, cure rate reaches 83.93%, effective 14 examples, invalid 1 example, total effective rate reaches 98.21%.Illustrate, medicine of the present invention emits laryngopharynx swelling and pain, the xerostomia caused to have significant therapeutic effect to treatment wind heat sexuality.
acute toxicity test:larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
Detailed description of the invention
embodiment 1:a kind for the treatment of is had sore throat, the medicine of xerostomia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Codonopsis 5-15g, Rhizoma Atractylodis Macrocephalae 5-15g, Poria 5-15g, Pericarpium Citri Reticulatae 5-15g, Rhizoma Dioscoreae 5-15g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 5-15g, Hemerocallis citrina Baroni 5-15g, Radix Saposhnikoviae 3-10g, Radix Rehmanniae 5-15g, Radix Scrophulariae 8-17g, Periostracum Cicadae 3-10g, Fructus Xanthii 5-15g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Radix Codonopsis 5-15g, Rhizoma Atractylodis Macrocephalae 5-15g, Poria 5-15g, Pericarpium Citri Reticulatae 5-15g, Rhizoma Dioscoreae 5-15g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 5-15g, Hemerocallis citrina Baroni 5-15g, Radix Saposhnikoviae 3-10g, Radix Rehmanniae 5-15g, Radix Scrophulariae 8-17g, Periostracum Cicadae 3-10g, Fructus Xanthii 5-15g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Semen Coicis, Fructus Setariae Germinatus (parched), Hemerocallis citrina Baroni, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Scrophulariae, Periostracum Cicadae, Fructus Xanthii pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:a kind for the treatment of is had sore throat, the medicine of xerostomia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Dioscoreae 10g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 10g, Hemerocallis citrina Baroni 10g, Radix Saposhnikoviae 5g, Radix Rehmanniae 10g, Radix Scrophulariae 12g, Periostracum Cicadae 5g, Fructus Xanthii 10g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Dioscoreae 10g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 10g, Hemerocallis citrina Baroni 10g, Radix Saposhnikoviae 5g, Radix Rehmanniae 10g, Radix Scrophulariae 12g, Periostracum Cicadae 5g, Fructus Xanthii 10g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Semen Coicis, Fructus Setariae Germinatus (parched), Hemerocallis citrina Baroni, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Scrophulariae, Periostracum Cicadae, Fructus Xanthii pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3: medicine of the present invention can also be decoction, oral liquid, granule etc.

Claims (5)

1. treatment have sore throat, the medicine of xerostomia, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Codonopsis 5-15g, Rhizoma Atractylodis Macrocephalae 5-15g, Poria 5-15g, Pericarpium Citri Reticulatae 5-15g, Rhizoma Dioscoreae 5-15g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 5-15g, Hemerocallis citrina Baroni 5-15g, Radix Saposhnikoviae 3-10g, Radix Rehmanniae 5-15g, Radix Scrophulariae 8-17g, Periostracum Cicadae 3-10g, Fructus Xanthii 5-15g.
2. treatment according to claim 1 have sore throat, the medicine of xerostomia, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Pericarpium Citri Reticulatae 10g, Rhizoma Dioscoreae 10g, Semen Coicis 15g, Fructus Setariae Germinatus (parched) 10g, Hemerocallis citrina Baroni 10g, Radix Saposhnikoviae 5g, Radix Rehmanniae 10g, Radix Scrophulariae 12g, Periostracum Cicadae 5g, Fructus Xanthii 10g.
3. treatment according to claim 1 and 2 have sore throat, the medicine of xerostomia, it is characterized in that: described medicament is decoction, capsule, tablet or pill.
4. treatment according to claim 3 have sore throat, the medicine of xerostomia, it is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Semen Coicis, Fructus Setariae Germinatus (parched), Hemerocallis citrina Baroni, Radix Saposhnikoviae, the Radix Rehmanniae, Radix Scrophulariae, Periostracum Cicadae, Fructus Xanthii pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry for step granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. treatment according to claim 4 have sore throat, the preparation method of the medicine of xerostomia, it is characterized in that the mixture described in step (2), the number of times decocted with water is 2 times, and first time be 60-80 minute, is 40-60 minute for the second time.
CN201410703229.1A 2014-11-29 2014-11-29 Medicament for treating throat pain and thirst and preparation method thereof Pending CN104491571A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109125558A (en) * 2018-08-21 2019-01-04 鲁振荣 A kind of Chinese medicine composition for treating flu

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101698054A (en) * 2009-11-24 2010-04-28 李晓恩 Preparation for treating sore throat
WO2011126295A2 (en) * 2010-04-06 2011-10-13 (주)아모레퍼시픽 Wrapping fermentation method using medicinal leaves, and composition for external skin application using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101698054A (en) * 2009-11-24 2010-04-28 李晓恩 Preparation for treating sore throat
WO2011126295A2 (en) * 2010-04-06 2011-10-13 (주)아모레퍼시픽 Wrapping fermentation method using medicinal leaves, and composition for external skin application using same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
宋兴等: "《中医疑难病秘验方大典》", 31 May 1995 *
张卓: "《疼痛名医诊治绝招大全》", 31 January 2002 *
王媛: "培土健脾法治疗慢性咽炎临床体会", 《内蒙古中医药》 *
邹文清: "参苓白术散临床应用举隅", 《湖北中医杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109125558A (en) * 2018-08-21 2019-01-04 鲁振荣 A kind of Chinese medicine composition for treating flu

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