CN104491355A - Medicament for treating intractable hiccup and preparation method thereof - Google Patents
Medicament for treating intractable hiccup and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
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- A61K9/2004—Excipients; Inactive ingredients
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a medicament for treating intractable hiccup and a preparation method thereof. The medicament is prepared from the following materials according to certain proportions by virtue of combination: codonopsis pilosula nnannf, asparagus, ruddle, pinellia tuber, desert cistanche, common anemarrhena rhizome and Chinese angelica. The traditional Chinese medicine composition disclosed by the invention has effects of calming the liver and reversion, cooling and stopping bleeding, removing dampness to reduce phlegm, reducing reversion and stopping vomiting, dissolving lumps and resolving masses, nourishing yin to reduce pathogenic fire, moisturizing pathogenic dryness to loosen the bowels and moistening the lung to clear away heart fire, and has a practical effect of treating intractable hiccup. The medicament disclosed by the invention is simple in preparation and low in cost, does not have toxic or side effects and is high in clinical application cure rate.
Description
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to a kind of medicine for the treatment of intractable singultus and preparation method thereof specifically.
Background technology
Singultus and intractable singultus, refer to gas superinverse from stomach, again and again utter a word between larynx, sound is anxious and very brief.Be phenomenon common on a physiology, caused by diaphragm spasm contraction.Also can there is transient singultus in Healthy People, how relevant with diet, and particularly too fast, the satiety of diet, take in awfully hot or cold food beverage, drink, ambient temperature changes and excessive smoking also can cause.Singultus is frequent or continue more than 24 hours, is called intractable singultus, is multiplely born in some disease.Normal health person can because of swallow too fast, gulp down gas or intra-abdominal pressure suddenly increases and causes singultus suddenly.How can disappear voluntarily.Sustainable long period had and become intractable singultus.At present, doctor trained in Western medicine cannot accurately judge the concrete cause of disease clinically, the therapeutic scheme that there is no, and mainly with treatments such as muscle relaxant, psychosis, antidepressants, antuepileptics, curative effect is also bad.At present, generally Chinese traditional treatment method is adopted clinically.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes a kind of medicine for the treatment of intractable singultus and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix codonopsis pilosulae (Radix Codonopsis) 4-8g, Radix Asparagi 3-6g, Haematitum 6-10g, Rhizoma Pinelliae 3-7g, Herba Cistanches 3-6g, Rhizoma Anemarrhenae 3-8g, Radix Angelicae Sinensis body 3-8g.Optimum ratio is: Radix codonopsis pilosulae (Radix Codonopsis) 6g, Radix Asparagi 4g, Haematitum 8g, Rhizoma Pinelliae 5g, Herba Cistanches 4g, Rhizoma Anemarrhenae 5g, Radix Angelicae Sinensis body 5g.Described medicament is decoction, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) Qu Fangzhong Radix codonopsis pilosulae (Radix Codonopsis), Radix Asparagi, Haematitum, the Rhizoma Pinelliae, Herba Cistanches, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis body pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
Radix codonopsis pilosulae (Radix Codonopsis): return spleen, lung meridian.Function cures mainly: invigorating middle warmer, and QI invigorating is promoted the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.
Radix Asparagi: sweet, bitter, cold.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, diphtheria.
Haematitum: there is suppressing the hyperactive liver town inverse, cooling blood for hemostasis effect.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.
The Rhizoma Pinelliae: there is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass effect.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.
Herba Cistanches: " abnormal smells from the patient " is sweet, tepor, nontoxic.There is YANG invigorating not dry, effect of the logical kidney yang the kidney invigorating void of temperature; " cure mainly " impairment caused by overstrain, essence loses dark complexion, nebulousurine of suffering from a deficiency of the kidney, hyperhidrosis constipation, easily hungry in disappearing, tetanus.
The Rhizoma Anemarrhenae: property bitter cold, has nourishing YIN to lower pathogenic fire, moisturizes laxation, the effect of sharp defecation.Gunpowder under genus heat clearing away, cures mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.
Radix Angelicae Sinensis body: having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of relaxing bowel.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
The present invention take Haematitum as monarch drug, and suppressing the hyperactive liver town is inverse, cooling blood for hemostasis, controls eructation vomiting, dysphagia and regurgitation.With Radix codonopsis pilosulae (Radix Codonopsis), the Rhizoma Pinelliae, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis as ministerial drug, invigorating middle warmer, QI invigorating, to promote the production of body fluid, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, nourishing YIN to lower pathogenic fire, moisturizes laxation, enriches blood and invigorates blood circulation.Assistant makes with Radix Asparagi, Herba Cistanches, and YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, YANG invigorating the kidney invigorating.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
beneficial effect
Chinese medicine composition of the present invention is inverse to having suppressing the hyperactive liver town, cooling blood for hemostasis, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, and nourishing YIN to lower pathogenic fire, moisturizes laxation, effect that lung moistening clears away heart-fire, and has practical curative effect to treatment intractable singultus.The preparation of this medicine is simple, cost is low, and have no side effect, clinical practice cure rate is high.
non-clinical statistical data
case is screened
2011-2013,intractable singultus patient 53 example, the course of disease is between 2 months-3 years.
therapeutic scheme
Decoction in embodiment 2 side, day potion that is decocted in water for oral dose takes at twice, within 30 days, is a course for the treatment of.
diagnostic criteria
Have the hiccups, during air-breathing, glottis is closed suddenly and is sent a kind of very brief sound, without other disease.
the standard of curative effect evaluation
Cure: clinical symptom disappearance, each index of lab testing blood biochemistry is normal;
Invalid: clinical symptoms is without significant change, and each index of lab testing blood biochemistry is normal; .
statistical result
| Case load | Cure | Invalid | Cure rate |
| 53 | 53 | 0 | 100.00% |
Conclusion
Through to 2011-2013,53 examples of coming to go to a doctor are had the hiccups patient, and after application we treatment, all successfully cure, cure rate reaches 100%.This medicine is to cure hiccup, and especially intractable singultus has significant curative effect.
clinical summary:clinical trial for many years and use, this medicine has practical curative effect to treatment intractable singultus.
acute toxicity test:larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
Detailed description of the invention
embodiment 1:a kind of medicine for the treatment of intractable singultus and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix codonopsis pilosulae (Radix Codonopsis) 4-8g, Radix Asparagi 3-6g, Haematitum 6-10g, Rhizoma Pinelliae 3-7g, Herba Cistanches 3-6g, Rhizoma Anemarrhenae 3-8g, Radix Angelicae Sinensis body 3-8g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Radix codonopsis pilosulae (Radix Codonopsis) 4-8g, Radix Asparagi 3-6g, Haematitum 6-10g, Rhizoma Pinelliae 3-7g, Herba Cistanches 3-6g, Rhizoma Anemarrhenae 3-8g, Radix Angelicae Sinensis body 3-8g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) Qu Fangzhong Radix codonopsis pilosulae (Radix Codonopsis), Radix Asparagi, Haematitum, the Rhizoma Pinelliae, Herba Cistanches, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis body pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:a kind of medicine for the treatment of intractable singultus and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix codonopsis pilosulae (Radix Codonopsis) 6g, Radix Asparagi 4g, Haematitum 8g, Rhizoma Pinelliae 5g, Herba Cistanches 4g, Rhizoma Anemarrhenae 5g, Radix Angelicae Sinensis body 5g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Radix codonopsis pilosulae (Radix Codonopsis) 6g, Radix Asparagi 4g, Haematitum 8g, Rhizoma Pinelliae 5g, Herba Cistanches 4g, Rhizoma Anemarrhenae 5g, Radix Angelicae Sinensis body 5g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) Qu Fangzhong Radix codonopsis pilosulae (Radix Codonopsis), Radix Asparagi, Haematitum, the Rhizoma Pinelliae, Herba Cistanches, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis body pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3, medicine of the present invention can also be decoction, oral liquid, granule etc.
Claims (5)
1. treat a medicine for intractable singultus, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix codonopsis pilosulae (Radix Codonopsis) 4-8g, Radix Asparagi 3-6g, Haematitum 6-10g, Rhizoma Pinelliae 3-7g, Herba Cistanches 3-6g, Rhizoma Anemarrhenae 3-8g, Radix Angelicae Sinensis body 3-8g.
2. the medicine for the treatment of intractable singultus according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Radix codonopsis pilosulae (Radix Codonopsis) 6g, Radix Asparagi 4g, Haematitum 8g, Rhizoma Pinelliae 5g, Herba Cistanches 4g, Rhizoma Anemarrhenae 5g, Radix Angelicae Sinensis body 5g.
3. the medicine for the treatment of intractable singultus according to claim 1 and 2, is characterized in that: described medicament is decoction, capsule, tablet or pill.
4. the medicine for the treatment of intractable singultus according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) Qu Fangzhong Radix codonopsis pilosulae (Radix Codonopsis), Radix Asparagi, Haematitum, the Rhizoma Pinelliae, Herba Cistanches, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis body pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of intractable singultus according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215149A (en) * | 2016-08-22 | 2016-12-14 | 常德永利盛祥生物科技有限公司 | A kind of Chinese medicine composition of cure hiccup and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579518A (en) * | 2009-04-08 | 2009-11-18 | 李永胜 | Granules and powdered medicine for preventing and treating vomiting |
| WO2011080723A2 (en) * | 2009-12-31 | 2011-07-07 | Himalaya Global Holdings Limited | A herbal composition for gastrointestinal disorders |
| CN103127484A (en) * | 2013-02-06 | 2013-06-05 | 张聿民 | Traditional Chinese medicine composition used for treating intractable hiccup |
| CN103656151A (en) * | 2013-11-26 | 2014-03-26 | 隗存富 | Chinese medicine formula for treating hiccup |
-
2014
- 2014-11-30 CN CN201410703952.XA patent/CN104491355A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579518A (en) * | 2009-04-08 | 2009-11-18 | 李永胜 | Granules and powdered medicine for preventing and treating vomiting |
| WO2011080723A2 (en) * | 2009-12-31 | 2011-07-07 | Himalaya Global Holdings Limited | A herbal composition for gastrointestinal disorders |
| CN103127484A (en) * | 2013-02-06 | 2013-06-05 | 张聿民 | Traditional Chinese medicine composition used for treating intractable hiccup |
| CN103656151A (en) * | 2013-11-26 | 2014-03-26 | 隗存富 | Chinese medicine formula for treating hiccup |
Non-Patent Citations (3)
| Title |
|---|
| 吴限: "《李延学术经验集》", 31 March 2014, 中国中医药出版社 * |
| 孙世发等: "《消化内科顽症金方》", 31 January 2007, 科学技术文献出版社 * |
| 陈进: "顽固性呃逆治验", 《实用中医药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215149A (en) * | 2016-08-22 | 2016-12-14 | 常德永利盛祥生物科技有限公司 | A kind of Chinese medicine composition of cure hiccup and preparation method thereof |
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