WO2011126295A2 - Wrapping fermentation method using medicinal leaves, and composition for external skin application using same - Google Patents

Abstract

The present invention relates to a composition for external skin application containing extract of wrapping fermentation using medicinal leaves, and more specifically, a composition for external skin application which contains the wrapping fermentation extract prepared by wrapping or covering natural products with medicinal leaves and fermenting the same, and which is thus excellent for skin in antioxidant, anti-aging, whitening and moisturizing effects.

Description

Ssam fermentation method using medicinal leaves and external skin composition using same

The present invention relates to a skin external preparation composition containing Ssam fermentation extract using medicinal leaves, and more particularly, to contain skin antioxidants, anti-aging, whitening and The present invention relates to an external composition for skin having an excellent moisturizing effect.

Human skin is changed by a number of internal and external factors as it ages. That is, internally, the secretion of various hormones that regulate metabolism decreases, and the function of immune cells and the activity of cells decreases, thereby reducing the biosynthesis of immune proteins and constituent proteins necessary for living organisms. Due to the increase in the amount of ultraviolet rays that reach the surface of the sun's rays and further increase environmental pollution, free radicals and free radicals, such as free radicals, skin thickness is reduced, wrinkles are increased, elasticity is reduced only In addition, the color of the skin becomes dull, skin problems frequently occur, and various changes such as blemishes, freckles, and black mushrooms also increase.

As aging progresses, symptoms such as changes and decreases in the content and arrangement of collagen, elastin, hyaluronic acid, and glycoproteins, which are constituting skin, appear, and are subjected to oxidative stress caused by free radicals and active harmful oxygen. In addition, cyclooxygenase-2 (Cox-2, cyclooxygenase), an enzyme that produces proinflammatory cytokine, which is known to cause inflammation, in most cells constituting the skin due to aging or ultraviolet rays. Biosynthesis increases, and the biosynthesis of matrix metalloproteinase (MMP), an enzyme that breaks down skin tissues by these inflammatory factors, increases NO (nitric oxide) production by inducible nitric oxide synthase (iNOS). It is known to increase. In other words, the biosynthesis of the substrate material is reduced by the reduction of cellular activity and micro-inflammation due to naturally occurring endogenous aging, and by external factors such as the increase of stress caused by various harmful environments and the increase of free radical species caused by sunlight. As a result, decomposition and degeneration are accelerated, and the skin matrix is destroyed and thinned, resulting in various symptoms of skin aging. Therefore, a lot of research is being conducted on the active ingredient that can prevent and improve the phenomenon of aging.

On the other hand, free radicals generated by various physical, chemical and environmental factors such as enzymes, reducing metabolism, chemicals, pollutants and photochemical reactions in the body are non-selective and irreversible to cell components such as lipids, proteins, sugars and DNA. It has been known to cause various diseases including cell aging or cancer by performing a destructive action. In addition, various peroxides in the body, including lipid peroxides produced as a result of lipid peroxidation by these free radicals, also cause oxidative destruction of cells and cause various functional disorders. Accordingly, antioxidants such as free radical scavengers or peroxide production inhibitors are expected as agents for inhibiting or treating aging and various diseases caused by these oxides.

Recently, there is an increasing demand for fermentation methods of natural products using natural fermentation methods without adding artificial elements according to the trend of well-being, and the demand for products using the same continues. However, this natural fermentation method is difficult to use as a real product due to the risk of decay and contamination by E. coli, anaerobic bacteria harmful to the human body. In order to solve this problem, a sterilization method before fermentation, such as a boiling method, has been devised, but the development of a fermentation method by a non-sterilization method is necessary because the potent component can be destroyed by heat.

Recently, with increasing interest in traditional fermented foods, methods for preparing various extracts using these fermentation techniques have been developed. Accordingly, the development of functional foods and cosmetics using natural product extracts having fermentation of natural products and the like, which has superior performance to existing natural products, has been continued.

Accordingly, the present inventors conducted a study to find a natural product extract having a superior performance than the existing natural products, as compared to the conventional simple natural extracts and fermented extracts, the fermentation extract prepared by wrapping or fermenting the natural products with medicinal leaves, the skin antioxidant It was found that the anti-aging, whitening and moisturizing effect is excellent and completed the present invention.

Accordingly, it is an object of the present invention to provide a skin external preparation composition which is excellent in skin anti-oxidation, anti-aging, whitening and moisturizing effects by containing the fermented extract of Ssam ferment having excellent skin efficacy.

In order to achieve the above object, the present invention provides a composition for external application for skin containing Ssam fermented extract prepared by fermentation by wrapping or covering natural products with medicinal leaves.

In addition, the present invention comprises the steps of boiling or steaming washed and dried natural products for 30 minutes to 2 hours;

Cooling the boiled or steamed natural product at room temperature for 30 minutes to 1 hour;

Wrapping or covering the cooled natural products with medicinal leaves and placing them in an ong fermentation at room temperature for 4-7 days in the shade; And

Removing and extracting medicinal leaves from the fermented natural products;

It provides a method of producing Ssam fermented extract, characterized in that it comprises a.

The medicinal leaf fermented extract according to the present invention exhibits excellent skin efficacy against antioxidants, anti-aging, whitening, and moisturizing, compared to natural extracts or general natural fermentation extracts before fermentation. It can be utilized.

The present invention provides a composition for external application of skin containing Ssam fermented extract prepared by fermentation by wrapping or covering natural products with medicinal leaves.

In addition, the present invention comprises the steps of boiling or steaming washed and dried natural products for 30 minutes to 2 hours;

Cooling the boiled or steamed natural product at room temperature for 30 minutes to 1 hour;

Wrapping or covering the cooled natural products with medicinal leaves and placing them in an ong fermentation at room temperature for 4-7 days in the shade; And

Removing and extracting medicinal leaves from the fermented natural products;

It provides a method of producing Ssam fermented extract, characterized in that it comprises a.

Hereinafter, the present invention will be described in more detail.

The medicinal leaves usable in the present invention are mulberry leaves, lower leaves, twig leaves, soybean leaves, bamboo leaves, mugwort leaves, peppermint leaves, ginseng leaves, green tea leaves, pumpkin leaves, persimmon leaves, loquat leaves, stone leaves, perilla leaves, and mulberry leaves. And a tree leaf is selected from the group consisting of one or more.

Mulberry leaves are called the upper leaves. The upper lobe is used for fever, headache, eye redness, sea water, dry mouth and skin urticaria. This medicine is sweet and bitter and cold. As a pharmacological action, antidiabetic action, inhibitory activity against typhoid fever bacillus, staphylococci, etc. have been reported.

The lower leaves are the leaves of lotus, a perennial aquatic herb belonging to the water lily family. In general, it is known that the lower lobe has a hemostatic effect, and the effect of haemorrhage and blood pressure is reported.

The twigs are the leaves of Adenophora triphylla var. Japonica Hara, which is a perennial plant of the dicotyledons. Leaves from the roots have long petioles and almost die off when they are round or flowery. It is used as Jinhae, expectorant, antipyretic, tonic and drainage.

The soybean leaves are the leaves of the Glycine max, a yearly herb from the dicotyledonous rosewood legume. It contains a large amount of vegetable protein and can reduce cholesterol in the body, and can provide an excellent effect as a source of protein and fiber.

Bamboo leaves are the leaves of an evergreen perennial plant belonging to a monocotyledonous rice plant (rice) and bamboo subfamily. It is used as a roofing material, livestock feed, food packaging, antipyretics and antidote.

Artemisia mongolica (A. asiatica, A. princeps, A. argyi, etc.) is a perennial herb belonging to the genus Compositae, which grows in many countries and has a unique aroma and taste. It has been reported to significantly prolong blood coagulation time, have anticancer effect, help anti-fungal action, anti-complement effect, help host's defense system, allergy or inflammation, and lower blood pressure and sedative effect.

Mint leaves are the leaves of the mint (Mentha arvensis L. var. Piperascens). It contains 70 to 90% by weight of menthol and 1% by weight of essential oils. Other essential oil components include isomentone, neomenthol, pinene, camphor, L-limonene and the like, and high boiling point components include gamma-hexenolphenyl acetate and ethyl amyl ketone. The essential oils of peppermint leaves vary depending on the variety. Recently, various kinds of peppermint leaves are known, including linalool as the main ingredient. The main ingredient, menthol, is medicinal as an applicator, painkiller, stimulant, or nutrient, and is used as a fragrance or refreshing agent in toothpaste, candy, jam, cosmetics, tobacco, etc.

Ginseng leaves are the leaves that return to the end of the stem of Panax ginseng C.A.Meyer. The ginseng leaves have long petioles and the leaf body is divided into five to form palm-shaped double leaves. Small leaves are small on the outside, and three of them are 4.5-15cm long and 3 ~ 5.5cm long with a sharp tip. Ginseng leaves contain saponin and various enzymes.As a result of saponin analysis of ginseng leaves, ginsengoid-Rd (ginsenoid-Rd), ginsenoid-Re (ginsenoid-Re) and ginsenoid-Rg1 among the saponins contained in ginseng root Ingredients such as (ginsenoid-Rg1) have been detected as main seronin components, and -Rb1, -Rb2, -Rc, -Rf, -Rg2, etc. have been detected as trace saponin components.

Green tea leaves are the leaves of Camellia sinensis, a plant of Theaceae, and the antioxidant, anti-cancer, blood cholesterol lowering, anti-aging, heavy metal detoxification, caries prevention, Attention has been greatly attracted as the effects such as bad breath removal have been demonstrated.

Pumpkin leaves are characterized by wide leaves and many hairs. Rich in fiber and vitamins, low calories are good for diet. It also removes the oxides in the body, and is known to have an anticancer effect.

Persimmon leaves contain flavonoid glycosides, tannins, phenols, resins, carcumin compounds, reducing sugars, polysaccharides, essential oils, organic acids, and chlorophyll. Flavonoid glycosides include astragarine and myristic, especially rich in vitamin C. Some persimmon leaves in June contain about 100mg in 100g. Persimmon leaves are said to be good for bronchial protection according to our traditional folk remedies, and because they contain a lot of vitamin C, they help to absorb minerals such as iron, which are easily lost after excessive drinking.

Loquat leaf is the leaf of Eriobotrya japonica, an evergreen subfamily of the dicotyledonous plant Rosaceae. Loquat leaf contains vitamin B17 (amicdarin) as a main component and contains uronic acid, oleanolic acid, tannin, saponin, and vitamin B1. Loquat leaf is effective in calming heart constipation, constipation and cold. Herbal wood is used to treat hangovers and gastrointestinal diseases after drinking alcohol, clearing blood, and having excellent effects on adult diseases such as hypertension, neuralgia, arthritis, and anti-cancer effects.

A leaf is a leaf of Pyrrosia lingua, an evergreen perennial herbaceous genus. Stone leaves sprout straight and sparsely. It is long oval or lanceolate, green on the outside, and yellowish brown on the back. It is mainly used as a diuretic and gonorrhea cure, and it is used as a medicine for diuretic pain, clear heat hemostasis, hemostasis, openness, stone forest, hemostasis, urine blood, urinary bulge, boric acid, waste heat seawater, and fever.

Perilla leaves are annual herb, 30 ~ 60cm high, of Lamiaceae family. The scientific name is Perillafrutescens Britton var. It is crispa Decne and is called somatic or lobules. Perilla leaf has excellent antiseptic effect in addition to bactericidal effect, and recently it has been found to have a high anti-cancer and anti-allergic effect, attracting attention as a well-being plant. The perilla leaves contain a large amount of β-carotene, a large number of vitamins 1, 2, 6, vitamins C, E, and Y, and niacin. It is also rich in calcium and other minerals such as iron, potassium, magnesium and zinc.

Mulberry leaf is a biennial herb that accompanies the mustard family. It is used for fever, headache, sore throat and mumps because it lowers and detoxifies the fever.

Tree leaves are the leaves of the deciduous broad-leaved arborescent (Clerodendron trichotomum Thunb) and are used for food or medicinal purposes.The young leaves are eaten as herbs and used as pills or as pills or powders. do. Mainly deals with diseases of the nervous and circulatory systems.

The natural products that can be used in the present invention are soybeans, cabbage, brown root, spicy meat, gamguk, dried Guangji, dried lacquer, licorice, health, nut, ginseng, red pepper, gobon, ginseng, gallweed, fruit fruit, gojija, gwakyang, baekbaek, tangerine, Gold Silver Coins, Gujeolcho, Chrysanthemum, Gil-Gyeong, Cucumber Tree, Locust, Male, Green Ginkgo Bridge, Mung Bean, Deer Antler, Twill, Poly, Donkey, Tangyuja, Daegye, Rhubarb, Hemp, Contrast, Daecheongcho, Rhubarb, Doin, Single Bowel, Cordyceps Sinensis , Tofu, ephedra, machi, manpyeongcho, ginseng, malt, mackmundong, quince, throat, cedar, mulee, bark, peppermint, windproof, half, cabbage, white bran, baekduong, baekmi, baekbaekja, sandalwood, baekryeom, baekbokyeong, baekbuja, Baekjain, Baekhwasaengchok, Baekjak, Baekji, Baekchul, Bokbunja, Bokryeong, Daebokpi, Rich, Leek, North Siho, Icepyeon, Apple Rock, Sasam, Sansam, Sansa, Sansuyu, Sanak, Sanjoin, Sanchija, Sanbaekcho, Shoju, Sanggi, Sangbaekpi, Sangsan, Sangup, Sergeant, Ginger, Seokchangpo, Seonhakcho, Seolchocho, Sessin, Leaflet, Pine , Small lump, small fennel, rapeseed seed, sokdan, pine, horseback riding, shiho, new song, night gate, night view, eoseongcho, yeonkyo, lotus, lotus root , Okmisu, Okjuk, Wasong, Yonggyu, Yongdamcho, Yonganyuk, Wooslung, Wonji, Wonhwa, Wolgamcho, Yuryeongseon, Yu Geunpi, Rapeseed, Breeding Dragon, Eunsiho, Yin Yang Kwak, Uiin, Motherwort, Ikjiin, Ginseng, Injin, Ildangwi, One leaf, one cheongung palace, jawan, self-portrait, peony, remnant, low root skin, spirit, red bokyong, red sesau, red cabbage, red peony, jeonho, hole blood, clove, carving, sculptor, stalk, bell yong, kill, phalanx, earth Tree, jimo, branch father, jisil, jiyu, jihwang, jinbum, jingapi, nacre, dermis, teapot, changja, cheongung, cheonma, cheonmundong, cheoncho, cheongyuja, cheonnyeoncho, cheonsan dragon, cheonsan seolyeon, cheonhwabun, cheongho, Excess, Choo, Gardenia, Blue Box, Temperation, Incense, Taeglan, Taxa, Tenza, Tobokyeong, Earthenware, Korean Palace, Tongcho, Breakthrough , Green onion, pogongyoung, huangpu, balloon orchid, sewage, alliance, pedestrian, yangil gyuja, hyangbuja, balm, hyangchunja, hyangpo, Hyunsam, local herb, Hyunho color, hyungae, homaine, fenugreek, pumpkin, red pepper, red ginseng, It is one or more selected from the group consisting of black tea mushroom, black tea Chukcho, safflower, Hwapi, golden, Astragalus, Hwangjeong, Hwangjeong, Hwangmaemok, Hwangbaek, hickak, black dog milk, and rare.

Beans are also called soybeans. It is widely cultivated as an edible crop, and its stem is 60cm ~ 100cm in height, and it is a straight and vine variety. Flowers bloom in mauve red or white in July-August, forming a stratified inflorescence on short stalks from axilla. Calyx is bell-shaped and has 5 ends. Corollas are butterfly-shaped, with 10 stamens. Fruits are edible, streaked, flat oval, with 1-7 seeds. When fully cooked, the pod bursts, dispersing the seeds. Seeds vary in size, including round, flat and round, depending on the variety. Seeds come in many varieties such as yellow, black, light brown, and green.

Caucasus removes the seeds from the mature fruit of the terminalia chebula Retzius and is a dried flesh used to treat diarrhea, dysentery, crayfish and prolapse.

It is used for talking about root roots, lowering heat and sweating, and for thirst, headaches, and low back pain.

It is a biennial or perennial herb with mountainous shape, and its height is more than 2 meters, and the leaves are split, displaced and feather-shaped. A small white flower blooms at the end of the branch in August-September and the fruit is oval. Root-like roots are used as antipyretics and painkillers in herbal medicine.

Gamguk is also known as yellow kingdom. It grows mainly in the mountains, has short hairs all over the grass, and the stem is 60-90cm in height and is black and thin. In October, the flowers are dried and drunk, and young leaves are used as herbs. The flower has a rich scent and can be used for ornamental purposes. It is prescribed for the treatment of cold, pneumonia, bronchitis, headache, gastritis, enteritis, and boil in one shot.

Geonjiwang refers to the roots of dried Jihwang, the fever down, and writes medicines such as blood and hemostasis.

Dried lacquer is dried by collecting the lacquer gin and used for dysmenorrhea, blood, and roundworms.

Licorice is a medicinal plant. Its roots are reddish brown deep into the ground, the stems are gathered, and grow straight about 1m. In addition, white hairs are dense and appear gray-white, and preemption is scattered. Flowers bloom in July-August, 1.4-2.5cm long, purple, and the roots are sweet, so they are used as sweeteners and herbal medicines.

Health is used for the treatment of vomiting and diarrhea for the purpose of saying dried ginger in one shot.

The dog refers to the seed of morning glory, and the seed of red flower is called black axis and the seed of white flower is called white axis. Used for the treatment of constipation, edema, extraction, back pain.

The deficiency refers to the seeds of the imperfection tea, which is a yearly herb. The stem is about 1 meter high and yellow flowers bloom in summer. The fruit bears a long, curved fruit, like a bow, the seed in which is a fault.

It refers to the root or bark of the pine bark. Used as an insect repellent.

Gobon is a perennial herb that grows at the foot of a deep mountain and is distributed all over Korea. Its height is 30-80cm and hairless and fragrant throughout the grass. It bears an oval fruit and the root is medicinal. In oriental medicine, roots are cut and dried in the fall and are prescribed for headache, joint pain, toothache, abdominal pain, diarrhea and eczema.

Ginseng is a perennial plant of legumes. Its height is 80-100cm, and in summer, pale yellow flowers in the shape of butterflies are shot inflorescences blooming on the ends of stems and branches. The roots are medicinal in a consensus. Ginseng mainly refers to roots. It is used for jaundice, school work, and bleeding because of its bitter taste.

Gallweed is a deciduous broad-leaved shrub of the legume, about 2 meters high, and spiny. The leaves are alternate, pinnate double leaves, yellow butterfly-like yellow flowers bloom in the axils one by one in spring, and the fruit ripens in the autumn as a cylindrical fruit. Cultivated for ornamental purposes, distributed in Korea and China.

Guruin is a perennial vine of seeds of gourd, 3 ~ 5m long, leaves alternate, palm-shaped. In July-August, purple flowers bloom on the axilla, and the fruits ripen yellow in a ball shape. Use it to help with milk and faeces, or to sink the boil.

The wolfberry is the fruit of the wolfberry, egg-shaped or long oval, 1.5-2.5cm long. It ripens red from July and is harvested in late July to late November. Used as antipyretic and tonic.

Gwakhyang is a perennial herb of Lamiaceae. The stem is 20 ~ 30cm high, hairs are all over the body, and the leaves are egg-shaped and serrated. In July-September, lip-shaped light red flowers bloom in gunshot inflorescences. It grows in the mountains and is distributed in Jeju and Hambuk.

Kwonbaek is a perennial herb of the Buddha family. The stem is about 30cm high, many branches are extended, and the leaves are dark green and have the shape of scales. When dry, the branches tend to grow inside, and when they meet a wet energy, they will reopen. Used to treat menstrual cramps and bleeding.

The tangerine peel refers to the peel of the tangerine and its warm properties help digestion, and it is effective in coughing, diarrhea and harvesting.

Gold and silver coin refers to the flower of honeysuckle, lowering the heat and acting to solve the poison is used in things like onggi.

Gujeolcho is a perennial herb of Asteraceae, 50cm high, with red and white flowers blooming at the end of the stems, fruits are aquatic in September-November. The herbal medicine Gujeolcho is dried stems and leaves. In oriental medicine and folk medicine, the entire grass with flowers is prescribed for typhoons, gynecological diseases and gastrointestinal diseases.

Chrysanthemum is a perennial herb of the Asteraceae family, about 1m high, and flowers usually fall in autumn, with various flower shapes and colors. Depending on the size of the flower, it is divided into large, Chinese, and small countries.

Gilgil is a perennial herbaceous plant with a campanula, 40 ~ 100cm high, leaves alternate, oval. The roots are plump, and one or several stems gather. In July-August, white or light blue flowers bloom and the fruit is capsule. Roots are edible or used as medicinal herbs or Jinhae.

Kudji Mulberry is a deciduous tree of the Mulberry family and has many thorns on its branches and hairs on young branches. The leaves are shifted and sometimes split into three branches. In May-June, male flowers bloom in yellow, and female flowers bloom in the shape of balls about 1cm in diameter. Several fruits come together to form one large fruit and ripen in red in September. It is known to be effective in repairing tinnitus.

A moth is also called an undergarment and refers to the radish of the cruciferous plant or the seed of the same plant. Used to pretend or to rule a wall.

Men are also known as Chunnamseong and are perennials of Chunnamseong. The height is 30 ~ 60cm, and the leaves are divided into several branches and have the shape of a bird's feet. Green flowers bloom in broth in May-July, and fruits are red berries. It is used to treat freshwater, seawater, strokes, and jeons.

Noggak Bridge is made of grass like an orphan with deer's horns. It has the effects of blood, hemostasis, and anxiety. It is used for low back pain, gonorrhea and crayfish.

Mung beans are also called andu and gildu. It grows well on warm climate loam (black soil mixed with sand and clay) and is 30 ~ 80cm high. In the private sector, it is used to treat skin diseases and has antipyretic and detoxification effects.

Deer antler is a soft horn of a newly sprouted deer that is used as a medicine to strengthen the musculature.

Twill is a fruit of perennial herbaceous fruit. Roots in the mud, the stem grows thin and long in the water comes out over the water and has a feather-shaped water roots. The leaves are clustered at the top of the stem, triangular, and have a bulging buoy with air in the petiole, floating on the water. In summer, white flowers bloom and the fruit is eaten as a nucleus. It is found in ponds and swamps, and is distributed in Korea, Japan, and China.

Dachae is a green-yellow vegetable belonging to the Cruciferaceae, and contains a lot of vitamins, also called vitamins or vitamin vegetables. Carotene, which is comparable to the effect of vitamin A, is twice the amount of spinach, and 100g of vitamins are enough to fill 80% of the daily needs, and it is rich in iron and calcium.

Angelica is the root of Seunggeumcho, a perennial herb of mountainous family. Mainly anti-inflammatory, analgesic action.

Dangyu is an evergreen sub-tree, 6m high, with a slight stalk. Leaves are large, egg-shaped, long oval, 10 ~ 13cm long, 4 ~ 5cm wide, leafy 1 ~ 2.5cm long, and blades 0.4 ~ 1cm wide. There is a shallow mount on the chloroplast. Fruits are obovate, 10 ~ 12cm in length, 9 ~ 10cm in width, 6 indoors and outside. The weight is usually 200g, but the large reaches 500g, and there are some irregularities on the surface.

Dagye is a perennial herb of the Asteraceae family, also known as thistle. Stems stand straight, 50-100cm high, with white hairs and cob-like hairs. Flowers bloom from June to August and purple to red. Two flowers hang on the ends of branches and stems. Used as a hemostatic agent.

The rhubarb is the germination of the legume Glycine max Merrill. It is used for limb paralysis caused by summer humidity, limb tingling, swelling due to stagnation of water, and low urine. It is also used to reduce heat caused by colds and sweat.

Hemp is a perennial plant of the dicotyledon and moss-planting branch. The stem is purple-colored with thick branches, the leaves are alternate, the petioles are long, and the edges are uneven. The corolla of flowers is a light purple with trumpets and a tubular calyx encloses the corolla. The end of the corolla is divided into 5, 5 stamens, 1 pistil. Fruits are thorns with a lot of spiny spines, and when ripened in October, they are divided into 4 pieces and black seeds are produced.

Contrast means jujube, also called wood wheat. The surface is reddish brown, elliptical, 1.5 ~ 2.5cm long, and ripe when red. Fruits are not only raw but also dried and dried. They are used for confectionery, cooking, and medicinal purposes. In oriental medicine, they are used as diuretic, tonic, and laxative.

Primrose is an outpost of Hygrophila salicifolia (Vahl) Nees. It is known to treat pandemic fever, jaundice, sputum sputum, stop coughing and hemorrhage (Chinese medicine dictionary). It contains about 25% oil and trace amounts of alkaloids, calcium phosphate and calcium chloride.

Rhubarb is a perennial herbaceous perennial plant, about 1m high, hollow, and leaves are 25 ~ 30cm long. Flowers bloom in July-August and the medicinal roots are medicinal in nature and have a bitter taste. They are used for feces, bullshit, drooling, harvesting, gongga, and blood.

Doin refers to Jain (relatively large granular body in seed) in peach seed. When peach ripens around July ~ August, it collects seeds, breaks the hard husks, and extracts the inside of Jain. It is used as a medicine for coughing, constipation, and blood.

Dokdyeong is also known as jeopduul, kkumdur. It grows in the mountains. It is 1.5m high and has some hairs except flowers. Leaves are alternate, 50-100cm long, 3-20cm butterfly, with light brown hairs when young. Small leaves are oval or oval and serrated at the edges. The leaf surface is green, the back side is white, and there are small cotyledon on both sides of the petiole. It is used for muscle pain, paraplegia, headache, paraplegia.

Cordyceps sinensis, also known as hawthorn cordyceps, is a term that refers to the mushrooms of the family Cordyceps sinensis, which means that what was cut in winter is grass in summer. It parasitizes in the bodies of insects such as spiders, cicadas, butterflies and bees. There are red cordyceps and cicada cordyceps.

The larva is a deciduous arborescent with the larvae, over 10m in height, and the leaves are alternate and oval. In oriental medicine, bark is used as a tonic and tonic, to strengthen the cerebrum, and to control lung and knee ailments and groin. Folk in the leaves decoction is used for neuralgia, high blood pressure, is also taken by car.

Ephedra is an evergreen shrub with ephedra, which grows in dry highlands or sandy soil. It is 30-70cm in height. Stems stand upright and many branching branches are split. There are many nodes, and a pair of scale-like membranes (thin paper-like translucent) leaves hang in pairs, and the bottom is joined to surround the main stem. The root is hard like a tree and reddish brown. It is effective in sweating, antipyretic, antitussive, diuretic and used to treat fever and asthma.

Machi is also called purslane in our country, and is used as feed or medicine. This herb has a soft, peculiar smell, mucus, tastes salty, and cold. It has antipyretic, detoxification, and hemostatic effects. It is used for bacterial dysentery, boils, hemorrhoids, cervical lymphadenitis, eczema, lobster, uterine bleeding, and urine. As a pharmacological action, antimicrobial action, intestinal peristalsis due to the enhancement of uterine smooth muscle contractility, and diuretic action have been reported.

Manbyeongcho is an evergreen shrub of the Azalea family dicotyledon and grows in high altitude. It is 1-4m in height. The bark is white with ash. The leaves are alternate, but at the end of the branch, 5-7 dogs are gathered together, and are oval or elliptic basso, and leather (texture like leather). 8 ~ 20cm long, 2 ~ 5cm butterfly, with flat edges and curled backwards. It is dark green on the outside and dense brown hairs on the back. Petiole is 1-3cm long. Used as a diuretic and tonic.

Mansam is a vine-perennial herbaceous plant with dicotyledon plant lantern flower campanula. Roots are bellflower-shaped, about 30cm long. Leaves are alternate, but opposite short branches, oval or oval-shaped, with fine hairs on both sides, and white on back. The leaves are 1-5cm long, 1-3.5cm long, and petioles are 2-3cm long. Used as an expectorant.

Malt is a grain of barley that germinates by acting moisture, temperature, and oxygen on the barley, and is used as a raw material for beer brewing, and is also used to prepare microorganism incubators. It contains sugars and vitamins such as starch, and has a strong amylase, which is used as a nutritional supplement, a digestive agent (diastatase, etc.), sometimes a livestock feed, and a raw material of maltose.

McMoon-Dong grows in the shade of evergreen with monocotyledonous liliaceae. Leaves grow out of short, coarse rhizomes to form abandonment, and often the tip of the root grows to become peanuts. Stems stand straight and 20-50cm high. Leaves are dark green, linear, 30-50cm long, 8-12mm butterfly, and the bottom is like leaf leaf. Flowers bloom in May-June, purple, and hang 3 to 5 at the node of inflorescence. It is used as an anti-inflammatory, tonic, cough, expectorant and cardiac agent.

The quince is a medicinal herb that is medicinal and tastes warm. Used for muscle flexion disorders, keratin and sedimentary eggs.

The neck is a stem of the rake (Akebia quinata Decaisne) or other homologous plant, which is made by removing the bark and cutting it horizontally, and when the revenge is caused by pyelonephritis, cystitis and urethritis due to moist heat of the bladder, the rash develops in the mouth. When, heartburn, red urine, used for numb pain.

Mokhyang is a perennial herb of dicotyledon plant Bellflower Asteraceae, stem is straight, 0.8 ~ 2m high. The whole hair is dense and grown with herbs. The leaves are alternate, oval or long oval, serrated at the edges, with dense hairs on the back. Flowers bloom in July-August, 5-10cm in diameter, yellow, with one headpiece on axilla. It is used for sweating, diuresis and expectorant, and has insect repellent.

Mui is a dried medicinal herb of Ulmus macrocarpa, which belongs to the elm family. It is also used for intestinal bleeding, hemorrhoids, and severe wounds.

Peel is a medicinal herb made from peony root bark, menstrual disorder caused by blood fever, dysmenorrhea, bruising, bleeding, nosebleed, spots, swelling due to fever, blood pressure rise, blood removal, bruises, anti-inflammatory It is used for pain relief, boil treatment, early appendicitis, and eliminates chest discomfort. In addition, pharmacological action has been reported analgesic, sedation, antipyretic, anticonvulsion, anti-inflammatory, antithrombotic, anti-allergic, gastric secretion, uterine mucosa, antibacterial action.

Peppermint is a perennial plant that is a perennial plant with a dicotyledon plant and a calligraphy plant. It grows in damp fields and has a height of 60-100 cm. Stems are rectangular in cross section with hairs on the surface. The leaves are faced with a single leaf with a sack and the edge is serrated.

Windproof is a medicine made by using the roots and rhizomes of Sapshnikovia divaricata Schiskin. Windproof is a very important medicine for treating wind diseases. The windbreak is columnar and the bottom is slightly thin. The outer surface is light brown, and the upper part of the root stem has densely-shaped vertical wrinkles, and the residues of the brown hairy leaf leaf are attached. External headaches, chills, fever, systemic pain, sore throat, etc. are effective for all symptoms.

It is a perennial herb of Cheonnamseong Mok Cheonnamseong, growing in the field, about 30cm high. Although it is toxic to egg roots, it is used for nausea, diarrhea and vomiting during pregnancy because it has the effects of expectoration and cough.

Cabbage is a biennial herb of the poppy family Mustardaceae, whose outer leaves are upside down, with broad white middle veins in the center of the leaves, green or light green. 100 g of Chinese cabbage contains vitamin A 33 IU, carotene 100 IU, vitamin B₁0.05 mg, vitamin B2 0.05 mg, nicotinic acid 0.5 mg, and vitamin C 40 mg. The pale white part does not have vitamin A, and the blue part is a lot.

Baekgulchae is the ground part of the Chelidonium majus Linne. Branches have many branched stems and opposite leaves. The stems are hollow and light brown. The leaf back is white green. The yellow and yellow latex comes out all over the body, so it is called celandine. Pharmacological actions have been reported for anticonvulsions, intestinal linkage and salivation, antitumor, hepatitis, and antibacterial activity.

Baekduong refers to the roots of Pulsatilla koreana Nakai or the same plant in the country. The outer surface is columnar, yellowish brown or brown with irregular longitudinal wrinkles, and the epidermis is easily peeled off to expose the yellow neck and there is a netting pattern. The head has white soft hairs and has stems and leaf spots. The quality is hard and crumbly, so it is easily bent and the face is flat. It is used for dysentery due to moist heat, amoeba dysentery, cervical lymphadenitis and hemorrhoidal bleeding.

White rice is a medicinal herb made from the roots of the Cynanchum atratum Bunge of the Panaxia family or similar plants. Pale yellowish brown thin roots are gathered in a short rhizome and form a hook. It is distinguished. White rice cools blood heat and consumes blood and essence of human body in the late or postpartum period of heat, so that the body does not have a slight fever and heals the symptoms of the body.The seawater, diuresis, boil, swelling, sore throat, snake caused by fever and lung fever Used for wound bites.

White is a medicinal herb that is dried on the tuber of orchid family. Its efficacy is a hemostatic drug used for hemostasis caused by lung fever and hemorrhage caused by stomach fever. It is used for surgical diseases such as boils and makes new flesh grow. In addition, local bleeding hemostasis, gastric and duodenal treatment, fungi, blood pressure increase, and anticancer activity were reported as pharmacological effects.

Sandalwood is an evergreen broad-leaved arboreous tree with dandelion, 6-10m high, glossy in bluish white, and the leaves are opposite and egg-shaped. The inside of the tree has a yellowish, good fragrance and is used for incense burners, medicines, and crafts.

Pleurotus is a word that reaches the root of a gae saw in one shot, and is used to treat window and burns.

Baekbokryeong is the dried core of Bokryeong, also known as Baeksol Pungryeong. It is also grown and cultivated where pine trees are cut all over the country. Baekbokryeong is parasitic at the root of red pine, and its taste is sweet and boring. It has been used as a tonic since ancient times, and acts on menopause, parenteral, heart, nerve, and bladder to protect the spleen, sputum, and stabilize the mind. The results of pharmacological experiments have been shown to act as a diuretic, lowering blood sugar, sedation, and also known as an immune resurrection.

The white man is also known as the Yellow Dolphin and grows in grass or shrubbery. The root is strong poison, but in herbal medicine, it is used as a painkiller and painkiller.

White porcelain refers to the seeds of the cypress fruit. It stabilizes the mind and body and makes the intestines lubricate, so it is used for vigilance, worms, cold, constipation.

White flower is the outpost of the Oledenlandia diffusa (Willd.) Roxburgh. The name is given because the white flower blooms and the flower resembles the tongue of a snake. Since it was first collected in Baekunsan, Jeollanam-do, Korea, it is also called Baekwoon Grass. It grows mostly in the southern part and Jeju Island. It is used for seawater, tonsillitis, and sore throat due to waste heat. It is also used for appendicitis, pelvic inflammatory disease, jaundice hepatitis and dysentery.

The earl is a perennial herb of the Buttercup family, grows in deep mountains and is 45 ~ 50cm high. Roots are used for pain relief, myrrh, and gynecological diseases.

White paper refers to the roots of the billiards, and is used for headaches, low back pain, and reflexes caused by colds.

Baekchul is a dried medicinal plant that removes the inflorescences of Asteraceae or the rhizome or bark of Baekchul. It has a peculiar smell, tastes a bit bitter, sweet and viscous and warm. The function of the stomach is weak, so that the news, boredom, yellowish face, thin stool or diarrhea, good for stagnation of water, swelling and digestion when the body is not digested. It is also used for coughing and clear phlegm, and for colds and limb pain with gastrointestinal disorders.

Bokbun is a medicinal herb made from unripe fruits of Bokbunja strawberry of Rosaceae. It has no smell, tastes sweet and warm. Enhancing the new function, it is used in oil wells, dreams, etc., it is used for weakening eyesight, lightens the body and makes the head black. It also makes the skin soft and beautiful. Pharmacological actions have been reported to anti-inflammatory, antioxidant and anti-Helicobacter pylori.

Bokryeong is a fungus with a fungus of Democratic Mushrooms, which is parasitic on the roots of pine trees. Mycelia are 10 ~ 30cm in size, round or elongated or lumpy. The surface is reddish brown, light brown or blackish brown and rustiness, sometimes with a broken skin. The flesh is white and gradually turns pink. White is called Baekbokyeong, and red is called red. In addition, pine roots are penetrating through the ghost of the god called blessed. All herbal medicines are effective in tonic, diuretic and soothing, so they are used for kidney disease, cystitis and urethritis.

Daebokpi is a medicinal herb (Areca catechu L .: bin) of ripened skin (Korea, China, Japan), and the term “daebok” is an analogy of the shape of seeds. The outer side is yellowish brown with vertical wrinkles, covered with a sloppy layer of fibers, the inner side is yellow or dark brown, and has a glossy, fine longitudinal wrinkle.The cut side is fibrous and the cross section is light tan. On a magnifying glass, the group of fibers appears to be light brown or dark brown spots, namely low betel nut, betel nut, betel nut, betel nut, abdominal hair, large abdominal muscle, large abdominal cord, and large abalone.

The rich man is a tuber of gourds belonging to the buttercup family, also called Odu. In oriental medicine, the excitement of the warmth, strong feelings, pain, diuretics, gyeji, bokyeong, licorice and common, and never use in one side. In addition to restoring extreme declines in metabolic function, it is used for cold, chills, numbness, pain, neuralgia, and rheumatoid arthritis.

Leek is a perennial plant of the family Liliaceae. The scaly stem has short rhizomes underneath and black yellow fibers on the outside. Scales are used for dry stomach, burns, etc., and soft plants are eaten. Seeds are used in herbal medicine as urinary medicine.

The Northern Siho is also known as 묏 Minari, grows in the grass, and is 40 ~ 70cm high. The root contains saponin and fatty oil, so it is used as a medicine for antipyretic, analgesic, tonic or respiratory, digestive and circulatory diseases.

Ice is also called the brain, it is a crystal obtained from the brain. It is directional and is confused with strokes, phlegm and fever, and is used to treat sore throats.

Apple Lac is a delusional fiber and tube in the fruit of Luffa cylindrica Roemer. When this herb ripens, the flesh becomes fibrous, so it is called Sa and La. Appearance slightly bent from long cylindrical to long ridge, and both ends are relatively thin. The outer surface is white or yellowish white and looks like a net with several layers of reticulated fiber intersecting the whole. This drug is light, vaginal and not broken. The cut side has three ovaries, three large cavities, and some black seeds remain in it. It is also called Mangwa, which means 'Oh of the Southern Oranca'. Edema of the customary arthritis, anti-inflammatory, redness in the redness, suppression of skin bacterial infection, etc. have been reported.

Samsam is a medicinal herb made from Adenophora triphylla var. Japonica Hara or the root of the same plant (Korea). Samsam is called ginseng along with ginseng, Hyunsam, Dansam and Gosam. Is similar. The name Samsam is white and grows well on sandy ground. The shape is fusiform or long conical, curved and sometimes has branch roots. Root stems with transverse wrinkles on the upper side. The root is light and easy to bend, and the cut side is milky white with many gaps. Pharmacological action, expectorant action, antibacterial action, hemolytic action, cardiac action, etc. have been reported.

Wild ginseng is a kind of highly effective ginseng that grows in deep mountains. It tastes sweet and bitter, and its properties are slightly warm. Rain, menopause to refresh the effect is.

Sansa is the name of the medicinal herb dried from the ripe fruits of the crataegus pinnatifida Bunge var.typica Schneider and related plants. The name Sansa is named after a fruit with an apple flavor and red color. It is also called red tide because its shape is similar to red jujube. Cardiac activity, blood circulation improvement, and blood pressure lowering have been reported.

Cornus is the fruit of the cornus tree, a deciduous tree of the dogwood family. Oval nucleus, initially green, ripens red in August-October. The pulp contains glycosides such as cornin, morroniside, loganin, tannin and saponin, and organic acids such as vitric acid, malic acid and tartaric acid. It also contains vitamin A and a large amount of sugar. From ancient times, herbal medicine was used as a medicine for headache, tinnitus, seawater disease, fever, excessive menstruation, etc. It is also used for folk remedies such as cold sweat and nocturnal enuresis.

A potion is the root of the tuber of the vine (Disocorea japonica) or the yam (Disocorea batatas) belonging to the Disocoreaceae, which is harvested and dried between winter solstice after autumn fall, and the outer surface is white or yellowish brown and the powdery or luxurious inside. It is hard with keratin.

Sanjoin is a medicinal herb made from jujube seeds and used for nervousness, insomnia, forgetfulness, cold sweat, etc., and strengthens the stomach and is effective for anemia. Pharmacological action, sedation, hypnosis, lowering blood pressure, analgesic, lowering body temperature, antioxidant activity, immune hyperactivity, uterine excitement has been reported.

The gardenia is the fruit of the gardenia berry, and it is used as a medicine for fever, hemostasis, and diuresis.

* Three hundred perennial is a perennial herb of more than three hundred dicots of the dicotyledonous plant. Root stock is white and lateral in mud. The stem is 50-100cm in height. Leaves are alternate, egg-shaped oval, 5-15cm long, pointed end, heart-shaped at bottom, 5-7 veins, flat edge. The leaf surface is green and the back is light white, but 2-3 leaves on the upper part of the stem are white. The petiole is 1-5cm long and the bottom part is wide to surround the stem. When the body is swollen and urine is not well used, each, jaundice, hepatitis, etc. is also used.

The shochu is a perennial herb of dicotyledon plant Campanula Asteraceae. The root stem is thick, long, node and fragrant. Stems stand straight, with several branches branched at the upper part, 30-100 cm high. Leaves from the roots dry out when they bloom. The leaves on the stem are displaced, and the leaves on the bottom of the stem are deeply divided into pieces. The split pieces are 3-5 pieces, long oval shape with ellipse shape or an upside down egg. The spines have sawtooth-like teeth and petioles are 3 ~ 8cm long. Leaves on top of stem do not split and few petioles. It is used as a medicine to create root stem, which is effective for sweating, diuresis, pain, and stomach, and is used for anorexia, indigestion, gastroenteritis, and cold.

Said life is dried herbs, leaves and stems of Mistletoe mulberry (Loranthus parasticus Merr.) Or mistletoe (Viscum album L. var.coloratum Ohwi), which has the effect of lowering blood pressure, dizziness caused by hypertension It is used to strengthen the bones and muscles with bare feet and is used in the womb.

Sanbaekpi is a medicinal herb made of mulberry or the same plant's root bark. Sanbaekpi treats seawater and asthma caused by waste heat and has a diuretic effect. It is used for acute pyelonephritis and fragile edema and has a blood pressure-lowering effect. It is also used for epidemic hepatitis. Pharmacological action is reported by Jinhae, diuresis, lowering blood pressure, sedation, analgesic, fever, jingyeong, antibacterial.

Sangsan is a deciduous shrub with the dicotyledonous Rhiococcus ulciaceae growing in the mountains. The height is 1.5 to 3m, the bark is grayish brown, and the young branch has a little hair. Leaves are alternate, two on each side, elliptical 5 ~ 13cm long or upside down with egg, pointed end, rounded bottom, flat or wavy sawtooth. The leaf surface is yellowish green, glossy, peculiar smell, and petiole is short. The root is used as a medicinal herb, which treats seawater, fever, and sore throat caused by colds, and is effective in customary arthritis, dysentery, boils, and school work.

The upper leaves are the dried herbs of Mulberry (Morus alba L.) or related plant, and the young leaves are also called upper limbs. The symbol for mulberry tree is a combination of medicine and tree, which means sacred god of the East. This was used to distinguish the two, because the mulberry, the tree that silkworms eat, is as effective as the new tree. The upper lobe is used for fever, headache, eye redness, sea water, dry mouth and skin urticaria.

The boss is also called Hongdu. The pods are used as arrow poisons because of the highly toxic abrin, and the leaves contain glycyrrhizin, which is sweetened like licorice and is a sweet drink.

Ginger roots are dried and used as a spice in bread, sweets, curry, sauces, and pickles. Peel, boil, and marinated in syrup. Ginger tea and ginger are also made. In herbal medicine, dried root stem is used as a health medicine, which is effective for indigestion, vomiting and diarrhea, promotes blood circulation, and has anti-inflammatory and analgesic effects.

Seokchangpo is a perennial plant of Cheonnamseongmok, a monocotyledonous plant, and grows in streams of mountains or fields. Root stems are sideways, beard roots come out from the nodes, and the nodes are long in the ground, but those on the ground are short and green. The leaves are clustered in the rhizome, 30-50cm long, string-shaped, without leaf veins, and sharp at the ends. The lower part of the outer leaf encloses the lower part of the inner leaf and staggers in two rows. Root stems are used as painkillers, sedatives, and stomach juices.

Seonhakcho is a perennial herbaceous plant of the family Rosaceae, also known as straw shinnyum. Dried outposts before flowering from summer to autumn are called Seonhakcho or Yongacho. do.

It is a plant of Lamiaceae and the root of Salvia plebeian R. Br. Is bitter and spicy. It is also effective in relieving swelling and is known to be used to treat hemorrhage, nasal bleeding, buds, bruises, and poisoning.

Seshin is a dried herb of perennial plants belonging to the Rataceae family. Dig roots between spring and summer, rinse thoroughly in water and dry in shade. Cold or windy head hurts, clogged nose, fever, phlegm, coughing, short of breath is used. Good for laryngitis, rhinitis, bronchitis.

Leaflets are annual herbaceous plants with nectar, 30 ~ 100cm high, leaves facing each other, egg-shaped, serrated at the edges. In August-September, light purple flowers bloom at the end of leaf axles or stems, and the fruits bear a round achene. Leaves and stems are used as medicinal herbs and young leaves and seeds are edible. It is also called perilla and chazuki and is called seed.

Pine is an evergreen coniferous plant of the family Asteraceae, and leaves are used as indigestion or tonic, flowers are dysentery, and rosin is used as raw material of plaster.

Grenade uses the root of Jasminum floridum Bge., A plant of the ash family, and is used for wound healing.

Small fennel is a yearly herb that is also known as dill. Flowers, leaves, stems, and seeds are used as herbs because they have a unique scent throughout. Seeds are good for digestion, gusts, sedation and hypnosis, good for removing bad breath and preventing atherosclerosis, and can be used as a pillow for a good night's sleep.

Seed seed is a seed of the seed medicinal plant and uses oily debris for diuretics, laxatives, edema, ascites and food poisoning. Indigenous seeds are highly toxic and care should be taken.

Sokdan is a perennial herb of the dicotyledon and moss plant. It grows in mountainous areas. Stems stand upright, about 1m high, with fine hairs all over, and roots have about 5 thick tubers. The leaves are facing each other, the petiole is long, and heart-shaped eggs. The leaf edge also has regular, dull teeth and fine hairs on the back. Coarse roots are used for gold sores and gynecological diseases.

Matsutake is an edible mushroom of the quince family with a unique aroma and taste that occurs on the pine forest land. In general, pine mushrooms occur in 20 ~ 60 year old pine forests, and pine mushrooms are symbiotic bacteria that attach to the roots of pine and form mycorrhiza.

Horseback riding is a perennial herb of the Buttercup family, and is also known as a staghorn. In oriental medicine, the root is called horse riding and used as an antipyretic and antidote. It has been reported that if you use a lot of heat with a cold, you will sweat and get fever.

Shiho is a perennial herb of the dicotyledonous cultivated plant Apiaceae. The root contains saponin and fatty oil, so it is used as a medicine for fever, pain relief, tonic, respiratory, digestive and circulatory diseases.

A new song is called a physical song and usually means a mixture of six medicines. Extinguishing the function of the digestive system and the action to help digestion has the effect of relaxing the inside. When you pretend, your chest is stuffy and full, vomiting and diarrhea, postpartum blood pain when the stomach is effective. Pharmacological experiments have been reported to have a health effect.

The night gate is a half-tree of the dicotyledon rose Rosaceae, also known as Nowoo Geun, Hojija, Wild Vegetables, and Non-Suri. It is used for lack of yang, ulcer, premature ejaculation, cough, whooping cough, and snake bites. As a pharmacological action, it has been reported that the seaweed action, expectorant action, Pyeongcheon action, action on the uterus, antibacterial action.

Yagyo, etc. refers to the stem of sewage, a vine perennial plant, with dicotyledonous plants, soybeans, and is effective for Jinhae, expectoration, and arthritis.

Eoseongcho refers to the terrestrial part of the flowering period of the weak wheat of more than three hundred. Echoseongcho is excellent for fever, drainage, cough due to lung abscess, pus, vomiting, pneumonia, acute pharyngitis, enteritis, urinary tract infections, boils, fever and urine can not be used. As a pharmacological action, antimicrobial action, immune enhancing action, anti-inflammatory action, diuretic action, antitussive action has been reported.

Fellowship is the fruit of the forsythia forsythia of the ash family. Yeonkyo lowers and detoxifies the fever and lowers the heart's fever in the early stages of fever, and is used for high fever and mental confusion, boils, rashes, appendicitis, lung abscesses, lymphadenitis, sore throat, and diuretic, anti-inflammatory. As pharmacological action, antibacterial action, anti-inflammatory action, blood pressure drop, hemostatic action, liver treatment action, antipyretic effect, clay, diuretic effect have been reported.

Lotus is the fruit of lotus. It is used for gynecological diseases.

Lotus is a seed of lotus and peeled and dried. It is a medicine that has been widely used because it helps the stomach and the spirit and energy, and when it is taken for a long time, it makes the body light, not old, hungry, and has a long life. Pharmacological action has been reported to inhibit nasal cancer and throat.

It is native to southern China and is often grown as fruit trees. The fruit is round and about 3cm in diameter, and looks like a turtle's back with a bump on the outside. The flesh is sour and sweet and has a unique scent and eats raw. In southern China, it is said to be the king of fruits.

* Yeochunhwa is also known as poppy flower, and the civilian separated the fruit and plant of poppy and used it for emergency diseases. Smoking opium with cigarettes leads to anesthesia, dullness, and addiction when habitual, and even death. Seed contains 45-50% fat, so it is used for food or industry. There is no anesthetic component.

Ganoderma lucidum is a semi-circular, elongated, or fan-shaped mushroom, which is effective in tonic, Jinhae, and small species in oriental medicine, and is used for nervous breakdown, heart disease, hypertension and various carcinomas. The mushrooms are covered with hard skin and have varnish like varnish. They are used as an herbal medicine in Japan and are used as decorative medicines.

Odu is also known as the rich root of the roots of the buttercup family. In oriental medicine, the excitement of the warmth, strong feelings, pain, diuretics, gyeji, bokyeong, licorice and common, and never use in one side. In addition to restoring extreme declines in metabolic function, it is used for colds, chills, numbness, pain, neuralgia, and rheumatoid arthritis.

Ogapi refers to the bark of the roots, stems and branches of the algae or the same plant. Ogapi strengthens the tendons and bones by keeping the liver and kidneys strong, so they are used for limb paralysis, cough, weakness in the lower back and knees, lower limbs, fractures, bruises, edema. Pharmacological action has been reported to enhance immune, antioxidant, anti-fatigue, anti-high temperature, anti-irritant, endocrine function, blood pressure control, anti-radioactivity, detoxification.

Schisandra chinensis is a fruit of Schisandra chinensis and is dark red with a diameter of about 1cm. The inside contains 1 to 2 red juice and reddish brown seeds. It has five flavors: sweet, sour, bitter, salty, and spicy, with strong acidity. It contains ingredients such as xanthrin, gomisin, citric acid, malic acid, and citric acid, which strengthens the heart, lowers blood pressure, and boosts immunity. Strong lung function, cough, expectorant action to help treat coughs and thirst.

The gall bladder is an insect lump formed by the locust bark of the cicada aphid and parasitic on the leaves of the Rhododendron of the sumac. It is often shaped like a human ear with an irregular bag shape. It is hollow and tastes very sour. In oriental medicine, it has the effect of astringent, hemostasis, detoxification, antibacterial, and is prescribed for diarrhea, prolapse, gastric ulcer, duodenal ulcer, cold, oil well, bloody stool, hematuria, stomatitis. It contains 50 to 60% of the tannin component, and is a raw material for hair dyes and inks including tannins.

Fructus is a deciduous arborescent of the dicotyledonous group of Lichen Fructus Rats, and it is called sewage or sorghum that is dried and harvested from brownish green immature fruit around September. It is used as dry, insect repellent, detoxification and diuretic.

Ojak is a tuber of dried Cheontaejak, which is used for the treatment of heart pain, each one, and urinary emptying by making the qi well, removing Hansa, and warming the kidneys and bladder.

Okmisu refers to corn whiskers in Chinese medicine. Adult diseases such as diabetes mellitus, blood pressure, cholesterol, diuresis, acute gastritis, nephritis, pregnant woman edema, fever, fever, hemostasis, stones, pleurisy, ascites, cystitis, urethritis, jaundice, hepatitis, gallbladder Used for cholecystitis, cirrhosis, arthritis, etc.

Okjuk refers to a dried herb root, and has the effect of clean and yin and yang.

Wasong is a perennial plant with dicotyledonous rosewood snails, growing on or near the rocks of the mountain. Medicinal whole grass as a tonic, leaves are used to squeeze juice and bite insects or burn. Excellent anti-cancer effect, effective for fever, hemostasis, hepatitis, eczema, dysentery, malignant tumors, burns.

Yonggyu is a perennial plant of the dicotyledon and moss-planting family, also known as kiln, kka paper, and camellia. In oriental medicine, the whole grass is dried and dried in summer and autumn, and it is prescribed for colds, chronic bronchitis, nephritis, high blood pressure, jaundice, boils, and cancer. In the private sector, the grass is crushed and glued to a diseased or injured place, or the decoction is used to wipe the affected area.

Gentian is a perennial herb of gentian and is used for jaundice, dysentery, vaginal itch, cramps, eczema caused by hepatobiliary fever, and it is compounded in hand and foot cramps due to high fever. Write on symptoms you can't hear. The pharmacological action promotes the protection of liver function and promotes the secretion of bile, and relatively strong inhibitory effect has been reported on Pseudomonas aeruginosa, modified bacillus, meningitis diplococci and Staphylococcus aureus.

Longan meat refers to alfalfa of longan in Apatiaceae. The texture is light, sticky, sweet, and has a unique scent. Longan meat is also used to think too much of the heart beating irregularly, forgetfulness, insomnia, indigestion and loose stools. It is used when postpartum blood is weak and edema occurs when you are unable to control anemia, boredom and sweat after illness. Pharmacological actions include scabies suppression, tonic action, antioxidant action, immune function activation.

The dew is the root of the knee or the dew with the amaranth. This drug is odorless and mucus. The taste is slightly bitter and the nature is flat without any bias. If you use raw materials to remove the blood and boils, if you boil the liver and gods to strengthen the muscles and skeleton. It is used for menstrual irregularities and postpartum abdominal pain by removing blood, supplementing bone marrow and making the penis well through arthritis, and treating rashes in the mouth and tongue caused by immunization sinus. In addition, pharmacological action, uterine excitement, cholesterol lowering action, diuretic action, hypoglycemic action, liver function improvement, and the like have been reported.

Wonji is a perennial herb of the dicotyledonous rat handiwork, and it is called as Wonji in oriental medicine, and it is used as an expectorant, tonic and gangjeong.

Wonhwa refers to the buds of the red azaleas of the Azalea family. Wonhwa is used for species to shed water in asthma, sea water and flanks. Also use only for abdominal swelling, boils, head rashes, urine, and stool. Pharmacological actions were reported to increase urine, suppress the intestinal and uterine movements, and kill insecticides.

Wolbongcho is another name called Evening Primrose, night scent, moon hawthorn, etc. Its root is used as a medicinal herb. Depending on the disease, the leaves are used. Efficacy in antipyretic, anti-inflammatory, good roots for colds, sore throat, bronchitis, dermatitis, seed cough is effective in diabetes, hypertension, obesity, and suppresses excessive accumulation of lipid components, including cholesterol, is applied to hyperlipidemia.

The lieutenant line is also called flower ari, and the root is called lieutenant line in oriental medicine and is used for gout, arthritis, jaundice and tetanus.

The roots of elder bark are the bark of elm, which are effective for stomach ulcer, duodenal ulcer, small intestine ulcer, colon ulcer, edema, edema, gastric cancer, rectal cancer, uterine cancer, diuresis, sinusitis, rhinitis, swelling, boil, and swelling.

Rapeseed is also called rape, and seeds contain 38-45% of oil. It is an edible oil containing 15-20% of soluble nitrogen and 20% of protein. It is the second most consumed after soybean oil. Write Flowers are wheat plants, and the fatty oil separated from the seeds is used as a meat-based, oil-based solvent or machine lubricant.

Breeding is a medicinal herb made from breeding with fructose or other closely related plant species. It has a peculiar smell, tastes sweet, sour, salty, bitter and warm. It is used for breeding, and it is used for constipation caused by dry intestine, low back pain of the lack of sinyang, weak and weakness of the legs, tinnitus, amnesia, oil well, yuno, infertility, crayfish, lower abdominal cold, bleeding, sweating, and constipation. In addition, pharmacological actions have been reported to lower blood pressure, promote saliva secretion, and improve respiratory paralysis.

Eun Siho refers to the roots of the crabs of Sukju. It has no smell, is beautiful, tastes sweet, and is slightly cold. It is used for fever, fever due to overwork, cold sweat, fever, and bloating. Pharmacological action has been reported to prevent atherosclerosis, prevent cholesterol accumulation, antipyretic, killing action.

Eum Yanggwa is the terrestrial part of the trilobite or other cognate plants of the barberry family. Eum yanggae is used for erectile dysfunction, oil well, cold uterus, cold limb, skin paralysis, gut wasabi, forgetfulness, paraplegia, back and knee weakness, hypertension, polio. Pharmacological action promotes semen secretion, lowers blood pressure, increases coronary blood flow, lowers blood sugar, lowers cholesterol, boosts immune function, Jinhae, expectoration, Pyeongcheon, sedation, fungi, anti-inflammatory action, chicken femoral growth and protein polysaccharide activation Reported.

Uiin refers to the seed that has removed the seedling of the rice barley. Uiyiin is a species, each, a stomach ulcer is a symptom of poor urine, diarrhea, edible use, etc. used for limb paralysis, pain, dyspnea and muscle pain, fever, drainage, appendicitis. The drug action has been reported anti-cancer, skeletal muscle contraction suppression, intestinal uterus suppression, sedation, analgesic, antipyretic effect.

Motherwort is the medicinal herb dried on the ground when the motherwort blossoms. Motherwort is amenorrhea, dysmenorrhea, postpartum uterine contraction, bleeding, abdominal pain when there is a blood to remove (瘀血) and help the uterus contractions. It has a light diuretic effect when the amount of urine decreases and does not come out well. It is used when the body is swollen. It is used for eczema, itching, and boils. Pharmacological action, uterine excitement, thrombolytic action, increased blood flow to the heart and coronary arteries, respiratory excitability, diuretic effect, skin fungal inhibitory action has been reported.

The ripe person refers to the ripe fruit of the ginger family. It is used when a runny nose flows due to abdominal bloating due to weakness of the stomach, weakness of the kidney due to weakness of the kidney function, frequent urination and weakness of feces, microurea, uterine bleeding during pregnancy, and spleen convergence. Pharmacological actions have been reported to increase cardiac contractility, suppression of ascites cancer cells, and ileal contractility.

Ginseng is a perennial herb of the dicotyledonous plant type Arboraceae, whose root is medicinal and its shape is human form. Ginseng is said to be a traditional medicine of Buddha, ripening and freshness.

Injin is a medicinal herb that dried the ground part of Asteraceae. Injin is used for jaundice due to moist heat, that is, acute hepatitis, fuming, systemic yellowness, red and low urine. It is also used for chronic hepatitis, cirrhosis, liver cancer, cholecystitis, and gallbladder stones. Eczema, scabies, ringworm, rubella, etc. It is also used for symptoms of fever and radiance due to skin diseases and spinal diseases. Pharmacological action has been reported to promote bile secretion, antipyretic, diuretic, antimicrobial, inhibitory effect of experimental cancer cells.

One-Dang-Dong-Gang is also called Japanese Donkey, Korean Dang-Dang-Gi, Cha-Dang-Gi-Gi, and Gai-Gang-Bow. The root of the mature Angelica is used as a medicinal herb, and it has immunity and is used for anticancer drugs. It is used for anemia, menstrual irregularities, cold shoulder pain, physical pain, and tonic. Pharmacological action has been reported to lower blood pressure and diuretic action.

One lobe is the herbal medicine name of the clown, has the effect of blood, euneun root, gonbi, pixin. It treats low back pain, limb paralysis, paraplegia, vulgaris, facial nerve palsy and polio after rheumatism.

Ilcheongung is a perennial plant with mountain type, and in other names, Cheonggung, Gungung, and Waegungung are called. It is effective for pain relief, cramping, foam, and blood.

Jawan is the root of the ant odor of the Asteraceae. It has a peculiar smell, it is a little bit sweet, bitter and sweet. Jawan softens the lungs and is used for seawater, sputum, asthma, ripening, and Pyeongcheon, especially for the treatment of blood mixing in old seawater and sputum. It is also used for sore throats and acute respiratory infections. As a pharmacological action, antitussive, expectorant, antibacterial and ascites cancer inhibitory activity has been reported.

Self-cultivation is a mushroom that grows on branches that extend above water such as lakes, ponds, and swamps.

Peony is a term used throughout the perennial herbaceous plant of the Nagaria Javit. The flowers are large and beautiful and are cultivated for ornamental purposes in the garden. There are Count, Crop, Red, and Hokkap. The taste is bitter and sour, and the nature is slightly cold. It has a blue blood effect and eliminates blood, which is used for fever, blood, menopause, and bruises.

It is a perennial herb that is a dicotyledon plant lantern flower, also known as Sasam, Takju, and Jenny. In oriental medicine, the root is called samsam and is used as Jinhae, expectorant, antipyretic, tonic, and drainage.

Low root baekpi is a bark of the roots of the leather from the root of the horse, diarrhea, diarrhea, it is effective in the symptoms of blood mixed with feces.

He is a mushroom of the fungus of Democratic Mushrooms, which is used as a diuretic in oriental medicine.

Jeokbokyeong is a medicine made by removing the outer layer with the fungus nucleus of Jangyeongbi, which is parasitic on the root of pine. Take off the outer skin with a knife and cut it to a suitable size and dry it in the sun. The white inside is Baekbokyeong, and the red one is called Redbokyeong. Fukryeong can not urinate and edema of the stomach and whole body, seawater, vomiting, diarrhea in the presence of nerve hypersensitivity for nervousness, oil wells, also used for heart edema. Pharmacological actions include diuresis, fungi, intestinal relaxation, ulcer prevention effect, hypoglycemic action, increased cardiac contractility, immunopotentiation, and antitumor action.

Drip sewage refers to a dried medicinal herb. The roots of red mocks are cut or split in the fall and dried to protect the intestines and stop diarrhea.

Red cabbage is a type of cabbage belonging to the Cruciferaceae, and is one of the representative healthy vegetables that have effects such as gastric ulcer, anti-aging, and liver function recovery. Because of its beautiful color, it is often used as a decoration for salads and as a vegetable sprout. There are more nutrients such as fructose and glucose, vegetable protein lysine and vitamin C than ordinary white cabbage. In addition, it is rich in vitamin U and is effective in gastric ulcer, and it is also considered as a representative healthy vegetable because it is rich in selenium (selenium), which plays a role in preventing aging, mercury poisoning, and restoring liver function. However, people who are cold and often have diarrhea should not eat much.

The peony peony is a kind of peony and is called a peony because it turns red when the root is cut.

Jeonho is a perennial herb in mountainous shape, about 1m high, branches are split, and leaves are long, petioles are split. In oriental medicine, the roots of body herbs are used for headaches, relieves and phlegm.

Hole blood is the depigmentation of barberry, a deciduous arborescent of the dicotyledon, Leepanhwa, Rosaceae. It is effective in tonic, wind and Jinhae, and it treats physical weakness, pain in pain, stomach pain, customs pain, sea water and white hair.

Clove, also called clove, is known for its good appetite because it is sweet and spicy.

Sculpture is also called johyeop, the fruit of the legume juniper. Johyup has a strong expectorant effect and is used for pulmonary tuberculosis, lung abscess, and chronic bronchitis. It is also used for mental confusion due to a stroke, inability to greet, jeongan, and also used for boils, skin ulcers and constipation. The pharmacological effects of gastric mucosal irritation, respiratory tract endocrine secretion promotion, antibacterial action, and central nerve palsy have been reported.

Carver refers to the thorns of the legume juniper. Engraver is a strong drainage, anti-inflammatory action used to boil and release the skin poison. As a pharmacological action, antipyretic and anti-inflammatory effects of acute tonsillitis have been reported.

Jordae is bamboo with a monocotyledonous rice plant.

Jongyong, also known as sarcoma, is a medicinal herb made using sarcoidoscopes of sarcoma or other related plant species. It is used for breeding, and it is used for constipation caused by dry intestine, low back pain of the lack of sinyang, weak and weakness of the legs, tinnitus, amnesia, oil well, yuno, infertility, crayfish, lower abdominal cold, bleeding, sweating, and constipation. Pharmacological actions have been reported to lower blood pressure, promote saliva secretion, and improve respiratory paralysis.

It is a horse that kills the thin inner skin of a cotton pad, and it has the effect of stopping the heat and stopping the sleep, erasing the wall and stabilizing the fetus.

Phalanx is a medicinal herb dried from the roots of a wolfberry or other similar plant. Phalanges are good for cold sweats, sea water, asthma, hemorrhage, nosebleeds, urine bleeding, high blood sugar, high blood pressure, neuralgia, headache, shoulder pain, muscle pain, back pain, and back and knee weakness. Pharmacological action has been reported to reduce blood pressure and blood sugar of the cardiovascular system.

Earth tree is also called earth tree bark and stem bark of barn tree. Earthwood has been reported to help blood circulation, release muscles, and hepatoprotective action as a pharmacological action.

Jimo is a monocotyledonous genus Limoaceae, whose root stem contains aponin and salsapokenin, which can be used as an ingredient in medicine. In oriental medicine, the root stem is used as a medicinal herb, used as an antipyretic, and has been reported to be effective in chronic bronchitis and diabetes.

The branch is a seed of the annual herbaceous genus, also known as the rapeseed or the expensive. The branch has been reported to be used as a tonic, diuretic and as a medicinal herb for hyperthyroidism and atopic symptoms.

Jisil refers to the young fruits of tanza trees, which are stagnant and full of chest and abdomen, swelling and swelling of the chest, tingling pain, swelling, indigestion, constipation, etc. It turned out. Pharmacological action, uterine contraction, gastrointestinal hyperactivity, cardiopulmonary action, diuretic effect has been reported.

Fat milk is the abbreviation of cucumber grass and is used for diarrhea, colitis, bleeding, swelling, and burns. Especially, it is used for bleeding various kinds of bleeding due to its strong hemostatic effect.

Jihwang is a plant of the Korean ginseng family, and in oriental herbs, raw jizohwang, dried dried geonjihwang, steamed dried sukjihwang is called. Sukjihwang is used as a blood donor, menstrual disorders, weak constitution, children's developmental insufficiency, dementia, premature ejaculation, erectile dysfunction, raw jizohwang is used for weak constitution, bleeding, nosebleed, uterine bleeding, menstrual irregularity, constipation It has been reported to be effective for thirst caused by internal thirst and internal organ fever and to stop blood and nosebleeds.

Jin Bum is a plant of the genus Amanaceae, which is used as a medicinal herb in oriental medicine. It has been reported to be used for arthritis, spasms of muscles and bones, jaundice, and urine due to its high wind, analgesic, and diuretic effects.

Jingapi refers to a kind of ogapi. Outside to eliminate the customs and meridians to communicate well, has an analgesic action inside the liver and kidneys to strengthen the function of the muscles and bones.

Jinjucho is an annual herb that grows in a field or grass. Other names are fox bead, single wild green, cruciferous pearl, yin and yang candle, soybean persimmon, edible fish, lake water, quinoa, wild rapeseed pearl, lacji oil, sound Persimmons, persimmons, yachocho, mountain pieces, leaf lords, yugamcho, young vinegar is also called. Jinjucho is known to have chronic hepatitis, nephritis, enteritis, dysentery and brightening eyes.

The dermis is the medicinal use of the fruit peel of tangerine trees. The dermis relieves clumping and strengthens the function of fat to treat only the abdominal swelling, belching, vomiting, nausea, indigestion, flatulence, drowsiness, and diarrhea. Removes seawater and phlegm and acts as a diuretic. Pharmacological action has been reported that the essential oil components have digestive stimulation, digestion, expectoration, anti-ulcer, anti-gastric secretion, cardiac, blood pressure increase, anti-allergic, bile secretion, uterine smooth muscle suppression, antibacterial action.

The tea is the seed of plantain in one shot. The teapot is used to urinate well, to control diarrhea, to clear eyes, and to stop coughing.

Changsha is the fruit of the Akomari of the Asteraceae. Changsha is a medicinal herb that removes winds and is used for sinusitis, rhinitis, headache, fever, cough, quadriplegia, and discomfort, skin itching and otitis media. Pharmacological actions have been reported in toxic reactions to essential oils and alkaloids, hypoglycemia, leukocyte reduction, cough, cardiac suppression.

Cheongung is an apiaceae plant that is effective in soothing roots, pain, and tonic in oriental medicine. It is used for headache, anemia, and gynecological diseases.

Cheonma refers to perennial herb of the monocotyledonous plant Orchidaceae Orchidaceae, and uses outpost for tonic, nervous breakdown, dizziness and headache.

Cheonmun-dong is a plant of the family Liliaceae. Its edible tender shoots are used for darkening, diuresis and tonic. It is reported that it is not recommended for people who are diarrhea due to cold body and bowel.

Cheoncho, also known as Sancho, is a medicinal herb made by removing seeds as much as possible from the bark of the horticulture or the skin of the same plant. Cheoncho is used for abdominal pain, diarrhea and toothache, asthma and low back pain caused by cold energy of the abdomen, and it is used for scabies, ringworm, vaginal itching, and scrotum eczema. Local anesthesia, intestinal linkage, and antibacterial activity have been reported as pharmacological action.

Cheongyuja, also known as frog claw, grows at the foot of a mountain and is 20 ~ 30cm high. In Chinese medicine, it is prescribed for urinary tract, urolithiasis, lymphadenitis, hemorrhoids, uterus, gonorrhea, game, and epilepsy. In folk medicine, when bitten by a snake or insect, it is steamed and attached to the wound.

Cheonnyeoncho is also called dracaena, with about 50 species distributed in the tropics. The leaves are parallel veins, leathery, knife-like leaves or broad ovals. 30-50cm long, 6-10cm butterfly, with petiole. The stem stands upright in wood, and at the end of the stem, the flower of the mountain is spiked, and the small flower with 6 petals grows.

Cheonsanryong is also called Maple Horse, and the root stem is used as a medicine called Cheonsanryong in oriental medicine. It is used to immerse the blood in the blood and immerse it in alcohol. It helps to reduce asthma and lower blood heat, so it is used for boils and skin rashes.

Cheonsan Seolyeon is the perennial herb (Cheonyeonhwa) of Chunsan, China. It is a perennial herb of the liana, which is a plant with the beard roots gathered in the thick and short rhizome, the stems standing upright, and the base of the stem is wrapped in scale pieces. Cheonsan Seolyeon especially helps men's rejuvenation, has a great effect on various women's diseases, cold sickness, kidney, arthritis, diabetes, customary cold hysteresis, and great effect on residual disease.

Cheonhwahwa, also known as sphincter, refers to the roots of the peeled skin of Hanultari or Yellow Hanultari. Heals thirst, boils and pus when the fluid is damaged by heat. Mainly lowers the heat of the lungs and stomach, making the essences to quench thirst and soothe the body. Pharmacological actions have been reported to inhibit malignant grapes and epithelial cell carcinoma, uterine smooth muscle excitability, hepatocarcinogenic effect, hypoglycemic activity, and bactericidal action.

Cheongho is said to be high among the arcs that refer to mugwort. Only Cheongho is called Ho. Cheongho turns off blood fever to treat nausea, headaches and vomiting caused by schoolwork and summer heat, and swelling of the bone due to fever, symptoms of mild fever and summer cold. It is said to improve the color of the face and make white hair black. As a pharmacological action has been reported to inhibit agonists, hepatostomosis suppression, lowering blood pressure, antipyretic, skin fungal suppression, Jinhae, expectoration, asthma, bile secretion, immune regulation.

The excess is a plant of ginger family, and the excess fruit is used in our country. Excess heats the stomach, dehumidifies, and is used for abdominal pain, abdominal swelling, nausea, vomiting and diarrhea.

Choo is a medicinal herb made from the lump root of the horticulture or the root of the same plant. Ciao is used for headaches, abdominal pain, boils, involuntary death, inability to greet, and guanwasa. It is used for the treatment of paralysis due to acupuncture, infertility, rheumatoid arthritis, neuralgia, low back pain and tetanus. Pharmacological effects include analgesic, sedation, anti-inflammatory, topical mildew, and cardiomotor excitement has been reported with high doses.

Gardenia refers to the fruit of gardenia, an evergreen shrub of the locust family. In oriental medicine, it has been reported to be effective in the treatment of insomnia and jaundice, anti-inflammatory, hemostatic and diuretic.

Blue box refers to the seeds of mandarin with amaranth, and blue box lowers the fever, so it is used for congestion, white convulsions, tears, light reluctance, high blood pressure, and headache. It is a pharmacological action used in eye diseases and applied to skin swelling.

Kwakhwa is a mallow flower, and Kwakhwa is used for white crabs, cold abdomen, fecal incontinence, bleeding, uterine bleeding, burns, and redness of the nose. It has been reported that pharmacological action is effective against malaria.

Acupuncture is an evergreen arboreal tree of Azalea, which is used as a medicinal herb in oriental medicine. It has soothing, dry stomach, and aeration.

The talan is the above-ground part before the flowering of the easy-to-flower nectar. Talanchoe is used for amenorrhea, menstrual cramps, postpartum abdominal pain and bruises caused by bleeding blood, and is effective for boils, liver dysfunction and postpartum urination. Among the drugs that release the blood, it does not damage the regular, it is applied to gynecology a lot. Strong action has been reported as a pharmacological action.

Taxi is also known as boiled greens and root stem is reported as a medicine for diuretics, species and gonorrhea in Chinese medicine.

A tanza is the fruit of a tanza, which is fragrant and medicinal.

Tobokyeong refers to the roots of Cheongmirae (Myeongmyeong and Mt.) vines. Tobokyeong contains a lot of starch, constipation, syphilis, gonorrhea, poisoning, swelling, chronic dermatitis, mercury poisoning, cold, neuralgia is known to be effective.

Tosa is a seed of the annual ginseng, a vine plant belonging to the Coniferous family. Tosa is known as a medicine that mainly protects the liver and kidneys, brightens the eyes, helps yang, and strengthens the kidney function. Impaired sexual intercourse in men with weak kidneys, semen flowing spontaneously, it is effective for dreaming. It strengthens the bones and strengthens the strength of the lower back, and weak kidney function to heal the sore and sore back and knees. It has also been reported to be effective in the treatment of diabetes and diarrhea, and in treating diabetes.

Tocheongung is the medicinal root of Tounggung, which is used for the treatment of jingyeong, soothing, strengthening blood pressure, vasodilation, and antibacterial action.

Tongcho refers to the stem of the tree splinter of the family Arboraceae. Tongcho has been reported to promote gonorrhea, urethritis, cystitis and postpartum milk secretion by lowering heat and increasing urine volume.

Paegukcheon is also called Noni, and leaves, stems, flowers, fruits and seeds have been used in folk medicine. According to ancient literature in the South Pacific region, it is listed as the best natural remedy. In fact, it contains ingredients such as anthraquinone and serotonin, which help digestion, reduce pain, and are effective in hypertension and cancer. Usually deeply rooted and grows in volcanic soil.

Phadu is an evergreen broad-leaved shrub with the Great Sage, and in Chinese medicine it refers to its seed. Tasteful and eagerly poisonous medicinal herb that is filled with water and is used for constipation.

Pogongyoung refers to a dried herb of a dandelion or related plant. It is a medicine that reduces heat poisoning and dissipates boils. It is used for swelling, mastitis, sore throat, and carbuncles (sentitis, pulmonary abscess, peritonitis). It is used for ocular hyperemia, acute hepatitis, jaundice and fever due to fever. As a pharmacological action, fungal action, immune function enhancement, bile secretion action, liver function protection action, and diuretic action have been reported.

Sulfur refers to the riches of the family or the pollen of the same plant. It is used to reduce blood fever, convergence, and topography, which is used for keratosis, hemorrhage, nosebleed, urine bleeding, and uterine bleeding, and improves blood circulation. As pharmacological action, uterine excitement, lowering blood pressure, menstruation, reducing blood coagulation time, suppressing tuberculosis bacterium growth, lowering cholesterol, etc.

A balloon orchid is called a balloon or a bag. It grows in coniferous forests and is about 30cm high. Root stock is fleshy, ellipsoid, with one leaf and stem at the end. Leaves have petioles and oval or oval in shape. The tip of the leaf is also sharp, rounded at the bottom, wrinkled vertically, and the back is purple.

Sewao is native to China and is grown as a medicinal plant. Reddish brown tubers are called sewage in Chinese medicine and are used as tonics, tonics and laxatives. The leaves are made of herbs and attached to the fresh leaves to absorb pus.

The alliance is also known as silkworm grass. It grows in marshes and stems stand up to 50-80 cm in height. Branches split off and hollow in the upper part. The leaves are alternated and single-lobed. Small leaves are 20 ~ 30 pairs, oval-shaped oval, flat at the edge, and white on the back.

A passerby is an apricot seed that is used in coughing, asthma, and constipation.

Hyangilgyu means sunflower seeds, lowers cholesterol levels and prevents cardiovascular disease and arteriosclerosis. In addition, it is rich in minerals such as calcium, potassium, iron, etc. It is also good for people with weak digestive, cold and weak. It is also rich in vitamin B antibodies, which have a pronounced effect on hypertension and nervousness.

* Hyangbu is a perennial herb that is a perennial herb that contains root essential oils and fatty oils, and is used in oriental medicine as headache, abdominal pain and irregular menstruation, and as a pulmonary tuberculosis drug in the private sector.

Humpback is a plant of the family Lamiaceae, also called Noyagi. In oriental medicine, dried flowers are called balm, and it is reported that they are used for the treatment of swelling, fever, diarrhea, hepatitis, gastritis, nasal bleeding and bad breath as perspiration, antipyretic, diuretic, and hemostatic agents.

Hyangchun is the fruit of oak. Hyangchun has the effects of swelling, acidity, and pain, and heals abundance, deep pain, rheumatic joint pain, and acid.

Hyangpo is also known as huangpo, and refers to the wealth of the family or the pollen of the same plant. Lower blood fever, convergence, hemostatic action is used for keratinemia, hemostasis, nosebleeds, urine bleeding, uterine bleeding, improve blood circulation is used for heart pain caused by agglutination of blood in the chest, postpartum pain pain, menstrual pain. Pharmacological action has been reported, such as uterine excitement, lowering blood pressure, jingyeong, reduction of blood coagulation time, mycobacterium tuberculosis growth, cholesterol lowering action.

Hyunsam is a perennial plant with Hyunsam, and is also called Great, Modern, Ear, and Horse Horse. In oriental medicine, it is reported that root is called ginseng and used as antipyretic for sore throat, boil and lymphadenitis.

Local grass is a year-round grass with a rat's hand grass. It removes customs and communicates meridians to strengthen the skeleton and muscles, so it is used for limb pain, joint pain, bruise. It is also effective for dysentery, chronic diarrhea and colic and enteritis. It is also effective for skin itching, scabies and swelling.

Hyun-ho color is a perennial plant of the genus Poppy-namo, also called Namhwachae and Wonho. In oriental medicine, tubers are reported to be used for blood decontamination, antispasmodics and analgesics.

The hyunggae is a year-old herb, and it is said that it is used to dry outposts in oriental medicine, and it is used when a cold causes fever, headache, sore throat, and bleeding in the boil.

Hominein is a word that comes from a single shot of sesame seeds or black sesame seeds, and is known to be effective for people with swelling or gray hair.

Fenugreek is a perennial herb that grows up to about 50cm in height. Fenugreek seeds are usually dried in the sun and medicated. Seeds contain a very small amount of essential oils, which contain about 40 components: different types of alkaloids, proteins and fats. Because of its warm nature and no poison, it has been used to treat bladder and kidney disease in Africa, the Middle East, and India, and has been used to treat people with cold sweats or full stomach. Today, it is effective to maintain the balance between blood sugar and insulin in the body, and is known to be effective for weight control.

Pumpkin is a vine-like annual herb that has the highest starch content among fruits and vegetables, and is known to be high in calories following potatoes, sweet potatoes and beans. It is usually used for cooking, and the berry contains a large amount of vitamin A and some vitamins B and C, which is very important as a vitamin source.

Hongmogapi refers to thorny ogapi whose thorn is reddish red.

Red ginseng is a red ginseng dried by steaming ginseng, which has sedative and excitatory effects on the central nervous system. It also acts on the circulatory system to prevent hypertension or arteriosclerosis. It also lowers hematopoietic and blood sugar levels, protects the liver, and acts indirectly on sexual and reproductive effects by acting on the endocrine system, has anti-inflammatory and anti-tumor effects, protects against radiation, and protects the skin. It also works to soften. The most important of the effects of red ginseng is the adaptogen effect, which has been scientifically proven to increase the ability of the living body to adapt more easily by protecting against various diseases such as leakage, stress, and other harmful effects from the environment.

Black tea mushroom is a tea with sugary tea that grows yeast and has a taste similar to lemon tea. Most of the acid is acetic acid, and other organic acids such as gluconic acid are also contained.

Black tea herb is a bean and perennial herb, called red shamrock and gold coin. In folk medicine, outpost was used as a diuretic, analgesic, digestive, sputum, and hemostatic medicine.

Safflower is also called safflower, and it is dried flowers called safflower. It is used for women's diseases, pain and stomachache in oriental medicine. It is squeezed with fruit and used for kerosene and edible oil. The oil squeezed from seeds contains a lot of linolic acid. Good for the prevention and treatment of atherosclerosis.

Hwapi is located on the outside of the stamens and pistil to protect the stamens and pistil, also known as flower cover.

Gold is a perennial herb of Lamiaceae. In oriental medicine, roots are used as antipyretic, diuretic, branch, edam and anti-inflammatory agents.

Astragalus is a perennial herb of legumes. It is commonly cultivated as a herb, and it is harvested in autumn in oriental medicine to remove outcrops and roots, and dried in the sun. It is called Astragalus of medicinal herbs. It has the effects of tonic, cold, diuretic, swelling, etc. It has been reported to be prescribed for uterine dislocation, visceral sewage, cold sweat, and peripheral nerve.

Huangshan is cultivated for herbal medicine, and in November, oriental medicine is harvested from the roots of 5-6 years old Hwangyeon and Korean Waxy Soybeans and dried in the sun. It is prescribed for the treatment of insufficiency, gastritis, enteritis, abdominal pain, vomiting, dysentery, palpitation, fevers, mental anxiety, sore throat, hemorrhage, nosebleeds, bleeding, and burns.

Hwangjeong is a word that comes from the root of bamboo shoots.

Hwangmaemok refers to dried branches of gingko ginger tree, and is used as a medicine for fish blood, abdominal pain, postpartum pain and phlegm in oriental medicine.

Hwangbaek refers to dried bark of anti-bark belonging to the Unhyang family. Peel the bark from the trunk before or after the summer to remove the rough skin or slice it to dry in the sun. This bark is used as a medicine, hypoglycemia, pneumococcal pneumoniae, pneumococcal tuberculosis, staphylococcus aureus, etc., while inhibiting the development of tumor cells, and inhibits the sterilization. When taken, palpation of gastric juice is promoted by palpation of taste reflexes, and also leads to edible hyperactivity. General alkaloids do not have a systemic effect, so even if administered in high doses can be used as a formal agent as well as a stomach agent. In addition, since it does not develop resistance to various bacteria, it can also be used as a cleansing disinfectant when epidemic eye disease is in epidemic. In addition, the effects of blood pressure lowering, central nervous system suppression, anti-inflammatory, etc. have been reported. In Oriental medicine, it is used for Hwangnyeon Haedoktang, Shihocheonggantang, and Hyeonggaeyeongyotang.

Hubak is an evergreen tree of the dicotyledonous plant of the genus Amphitaceae, and in the oriental medicine, the bark is called hoobakpi and is used for asthma and gastrointestinal diseases.

Black dog cow refers to black seeds of morning glory. Collect seeds from September to October, dry them in the sun, pick dry ones and collect only dry seeds. White dog is white and black dog is black dog. Is no different.

A rare rice is a medicinal herb made from the hairy chrysanthemum or the ground of the chrysanthemum. It is used to remove customs, and to write on arthritis, limb pain, paralysis, paralysis and paralysis, and to boil, rash, itching and eczema. Use for high blood pressure, headache, dizziness, acute hepatitis, etc. As pharmacological action, joint edema suppression and blood pressure lowering action have been reported.

Ssam fermentation extract of the present invention is boiled or steamed for 30 minutes to 2 hours washed and dried natural products; Cooling the boiled or steamed natural product at room temperature for 30 minutes to 1 hour; Wrapping or covering the cooled natural products with medicinal leaves and placing them in an ong fermentation at room temperature for 4-7 days in the shade; And extracting and extracting medicinal leaves from the fermented natural products.

Generally, when natural products are fermented without mixing sugars, salts or yeasts, the natural products are not fermented and decay. However, when the natural products are fermented using medicinal leaves according to the method of the present invention, the natural products are not rotten without addition of sugar, salt or yeast. There is an advantage that can be fermented without.

Ssam fermented extract of the present invention is contained in an amount of 0.001 to 30% by weight based on the total weight of the composition. If it is less than 0.001% by weight, the desired effect cannot be expected. If it exceeds 30% by weight, the increase of the effect is insignificant compared to the increase in content, and the formulation stability may be deteriorated.

Ssam fermented extract using medicinal leaves according to the present invention is very excellent in skin antioxidant, anti-aging, whitening, moisturizing effect.

In the external preparation composition for skin of the present invention, the external preparation composition for skin has a softening lotion, nourishing cream, massage cream, nourishing cream, essence, pack, gel, ampoule or skin adhesive type cosmetic formulation, lotion, ointment, gel, It is characterized by having a transdermal dosage form such as a cream, patch or spray.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the scope of the present invention is not necessarily limited to these examples.

Example 1 Preparation of Rat Eye Extract Fermented in Mulberry Leaf Ssam Form

1.5kg of commercial rat bean (= Seomoktae) was put in 2L of water and boiled for 1 hour at medium heat (60-80 ℃). The boiled rat eye was picked up with beans and cooled for 1 hour at room temperature. The cooled rat eye was wrapped in 30g of mulberry leaves and tied up in cotton thread so that the mulberry leaf would not be released. In the same way, boiled rats soybeans wrapped in mulberry leaves and put ingredients in Onggi was stored for 7 days at room temperature in the shade. Thereafter, after removing the mulberry leaves, the rats' eye beans were collected and crushed with a blender. Then, 7 L of 80% ethanol aqueous solution was added, and refluxed three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 344 g of mulberry leaf paste fermented rattan extract.

Example 2 Preparation of Cornus Extract Fermented in Lower Lobe Ssam Form

1.5 kg of commercial cornus oil was steamed for 1 hour at medium heat (60-80 ° C.) using 2 liters of water. After picking out steamed cornus, it was cooled for 1 hour at room temperature and wrapped in 20g of chilled cornus oil and tied to a cotton thread so that the lower lobe could not be released. In this way, steamed cornus was wrapped in the lower leaves of the ingredients in the Onggi was stored for 7 days at room temperature in the shade. Thereafter, after removing the lower lobe, the cornus oil was collected, pulverized with a blender, and 7 L of 80% ethanol aqueous solution was added thereto, followed by extraction under reflux three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 412 g of lower loaves fermented cornus extract.

Comparative Example 1 Preparation of Rat Bean Extract

1.5 kg of commercial rat bean (= Seomoktae) was pulverized with a blender, and 7 liters of 80% ethanol aqueous solution was added, and refluxed three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 386 g of mouse eye extract.

Comparative Example 2 Preparation of General Fermented Rat Bean Extract

1.5kg of commercial rat bean (= Seomoktae) was put in 2L of water and boiled for 1 hour at medium heat (60-80 ℃). The boiled rat eye was delivered and cooled for 1 hour at room temperature. The cooled rat eye was placed in Onggi and stored for 7 days at room temperature in the shade. At this time, unlike Examples 1 to 2, it was observed that the rats' eyes are not fermented properly and rot. Thereafter, the mouse eye was pulverized with a blender, and 7 L of 80% ethanol aqueous solution was added thereto, followed by extraction under reflux three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 368 g of general fermented rat bean extract.

Comparative Example 3 Preparation of General Fermented Mulberry Leaf Extract

1kg of the commercial mulberry leaf was put in 2ℓ of water and boiled for 10 minutes at medium heat (60 ~ 80 ℃). After removing the boiled mulberry leaves, cooled to room temperature for 1 hour and put it in Onggi for 7 days at room temperature in the shade. At this time, unlike Examples 1 to 2, it was observed that the fermentation of mulberry leaves are not properly made and rotten. Thereafter, the mulberry leaves were pulverized with a blender, and 7 L of 80% ethanol aqueous solution was added thereto, followed by extraction under reflux three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 258 g of general fermented mulberry leaf extract.

Comparative Example 4 Preparation of Cornus Extract

1.5 kg of commercial cornus oil was pulverized with a blender, and 7 L of an 80% ethanol aqueous solution was added thereto, followed by extraction under reflux three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 355 g of cornus oil extract.

Comparative Example 5 Preparation of General Fermented Cornus Extract

1.5kg of commercial cornus oil was added to 2L of water and steamed for 1 hour at medium heat (60-80 ℃). After steaming steamed cornus, it was cooled for 1 hour at room temperature, and cooled cornus oil was placed in Onggi for 7 days at room temperature. At this time, unlike Examples 1 to 2 it was observed that the fermentation of cornus milk is not made properly, but rotting. Thereafter, the cornus oil was pulverized with a blender, and 7 L of 80% ethanol aqueous solution was added thereto, followed by extraction under reflux three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 331 g of general fermented cornus oil extract.

Comparative Example 6 Preparation of Normal Fermented Lower Lobe Extract

1 kg of commercially available lower lobe was placed in 2 L of water and boiled for 10 minutes at medium heat (60-80 ° C). The boiled lower lobe was harvested, cooled at room temperature for 1 hour, and placed in pottery and stored for 7 days at room temperature in the shade. At this time, unlike Examples 1 to 2, it was observed that the fermentation of the lower lobe is not performed properly and rots. After crushing the lower lobe with a blender, 7 L of 80% ethanol aqueous solution was added, and refluxed three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation, and the separated filtrate was concentrated under reduced pressure to obtain 263 g of a general fermentation lower lobe extract.

Comparative Example 7 Preparation of Rat Eye Extract Fermented with Mixed Mulberry Leaves

1.5kg of commercial rat bean (= Seomoktae) was put in 2L of water and boiled for 1 hour at medium heat (60-80 ℃). The boiled rat eye was picked up and cooled for 1 hour at room temperature, and 10 g each of mulberry leaves cut to 30 g of the cooled rat eye bean was cut to a suitable size. In this way, mulberry leaves mixed with boiled rat bean ingredients were put in Onggi and stored for 7 days at room temperature in the shade. Thereafter, after removing the mulberry leaves, only the rat eye was collected, crushed with a blender, and 7 L of 80% ethanol aqueous solution was added, and refluxed three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 351 g of the mulberry leaf mixed fermented rattan extract.

Comparative Example 8 Preparation of Cornus Extract Fermented with Mixed Lower Leaves

1.5 kg of commercial cornus oil was steamed for 1 hour at medium heat (60-80 ° C.) using 2 liters of water. After steaming steamed cornus, it was cooled for 1 hour at room temperature, and 10g each of the lower lobe cut into suitable sizes was mixed with 20g of chilled cornus. In this way, steamed cornus oil mixed with the lower lobe was put in the pot and stored for 7 days at room temperature in the shade. After removing the lower lobe, only the cornus oil was recovered and pulverized with a blender. Then, 7 L of an 80% ethanol aqueous solution was added, and refluxed three times, followed by immersion at 15 ° C. for 1 day. Thereafter, the residue and the filtrate were separated through filter cloth filtration and centrifugation. The separated filtrate was concentrated under reduced pressure to obtain 408 g of a mixed leaf fermentation cornus extract.

Test Example 1 Antioxidant Effect Test (DPPH Test)

In order to examine the antioxidant effects of the extracts prepared in Comparative Examples 1 to 8 and Examples 1 and 2, the organic radical DPPH (1,1-diphenyl-2-picrylhydrazyl; 1,1-diphenyl-2 It was performed as a method of evaluating the antioxidant capacity by comparing the DPPH oxidation inhibitory effect through the change in absorbance generated by the reduction of -picryl hydrazyl). That is, the extracts obtained in Comparative Examples 1 to 8 and the extracts obtained in Examples 1 and 2 were inhibited from the oxidation of DPPH, and the degree of absorbance was decreased compared to the control group, and 50% or less of the absorbance of the control group was measured. The concentration showing the absorbance of was evaluated as the effective antioxidant concentration.

190 μl of 100 μM (in ethanol) DPPH solution and 10 μl of Comparative Examples 1 to 8, Examples 1 to 2, and the positive control group, respectively, were added to the reaction solution, and the reaction was performed at 37 ° C. for 30 minutes. Measured. As the positive control group, Trolox, a synthetic antioxidant widely used, was used. DPPH analysis results of each substance are shown in Table 1 below, and IC ₅₀ means the sample concentration when the absorbance was reduced by 50% by the added sample.

Table 1 DPPH analysis results

Test substance		IC 50 (ppm)
Trolox		45
Comparative Example 1	Rat Bean Extract	66
Comparative Example 2	Normal Fermented Rat Soybean Extract	96
Comparative Example 3	General Fermented Mulberry Leaf Extract	91
Comparative Example 4	Cornus Extract	71
Comparative Example 5	General Fermented Cornus Extract	99
Comparative Example 6	Normal Fermented Lower Lobe Extract	80
Comparative Example 7	Mulberry Leaf Mixed Fermented Root Bean Extract	47
Comparative Example 8	Lower lobe mixed fermented cornus extract	54
Example 1	Fermented Root Bean Extract of Mulberry Leaf Ssam	19
Example 2	Lower Lobe Ssam Fermented Cornus Extract	24

As can be seen in Table 1, the antioxidant capacity of the mulberry leaf Ssam fermented fermented soybean extract and lower leaf Ssam fermented cornus extract of Examples 1 to 2 was significantly superior to the raw product extracts (Comparative Examples 1 and 4) as well as a positive control group. Compared to trolox, a synthetic antioxidant used, the effect was much better. On the other hand, the general fermented extract fermented without medicinal leaves (Comparative Examples 2, 5) was found to have almost no antioxidant effect. In addition, in the case of simple mixed fermentation extract (Comparative Examples 7, 8) rather than Ssam form, the antioxidant activity was slightly increased compared to the raw extract, but the effect was insufficient compared to the fermentation method of Ssam form.

Therefore, medicinal leaf ssam fermented extract according to the present invention was found to have excellent antioxidant effect.

Test Example 2 Anti-Aging Effect Test I (Measurement of Collagenase Expression Inhibition Effect)

The collagenase production inhibitory ability of the extracts obtained in Comparative Examples 1 to 8 and Examples 1 and 2 was measured in comparison with tocopherol and EGCG. Tocopherol and EGCG are antioxidants and are known to have the function of regenerating the epidermal cells of the skin to prevent aging of the skin.

The test was performed by placing human fibroblasts at 5,000 cells / well in a 96-well microtiter plate containing Dulbecco's Modified Eagle's Media (DMEM) medium containing 2.5% fetal calf serum. Incubate until 90% growth. Thereafter, the cells were incubated in serum-free DMEM medium for 24 hours, and then, each of the extracts of Comparative Examples 1 to 8, Examples 1 and 2, tocopherol and EGCG dissolved in serum-free DMEM medium was treated at 10 ^-4 molarity for 24 hours. After that, the cell culture fluid was collected.

The collected cell culture solution was measured for collagenase production using a commercially available collagenase measuring instrument (Amersham Pharma Co., Ltd., USA). First, the collected cell culture was placed in a 96-well plate uniformly coated with primary collagenase antibody, and the antigen-antibody reaction was performed in a thermostat for 3 hours.

After 3 hours, the chromophore-bound secondary collagen antibody was placed in a 96-well plate and reacted for another 15 minutes. After 15 minutes, the coloring stimulant was added, causing color development at room temperature for 15 minutes, and 1M sulfuric acid was added again to stop the reaction (color development). The color of the reaction solution was yellow and the degree of yellow color was different according to the progress of the reaction.

The absorbance of the yellowish 96-well plate was measured at 405 nm using an absorbance meter, and the degree of synthesis of collagenase was calculated by Equation 1 below. At this time, the reaction absorbance of the collected cell culture medium of the group not treated with the composition was used as a control. That is, the expression level of collagenase in the non-treated group was set to 100, and the collagenase expression level in the group treated with the test substance was calculated. The results are shown in Table 2 below.

Equation 1

TABLE 2

Test substance		Collagenase expression level (%)
Untreated group		100
Tocopherol		75
EGCG		60
Comparative Example 1	Rat Bean Extract	91
Comparative Example 2	Normal Fermented Rat Soybean Extract	99
Comparative Example 3	General Fermented Mulberry Leaf Extract	94
Comparative Example 4	Cornus Extract	89
Comparative Example 5	General Fermented Cornus Extract	98
Comparative Example 6	Normal Fermented Lower Lobe Extract	90
Comparative Example 7	Mulberry Leaf Mixed Fermented Root Bean Extract	81
Comparative Example 8	Lower lobe mixed fermented cornus extract	79
Example 1	Fermented Root Bean Extract of Mulberry Leaf Ssam	69
Example 2	Lower Lobe Ssam Fermented Cornus Extract	60

The lower the expression level of collagenase, the higher the expression inhibiting ability of collagenase and the less the amount of wrinkles generated due to less degradation of collagen in the skin. In Table 2, the mulberry leaf Ssam fermented fermented soybean extract and the lower leaf Ssam fermented cornus extract according to the present invention inhibited the expression of collagenase more effectively than the raw product extracts (Comparative Examples 1 and 4) in vitro , It was confirmed that collagenase expression inhibition was superior to tocopherol known as an antioxidant. On the other hand, normal fermented extracts (Comparative Examples 2 and 5) fermented without medicinal leaves showed little anti-aging effect as collagenase expression suppression ability was similar to that of the untreated group. In addition, in the case of simple mixed fermentation extract (Comparative Examples 7, 8) rather than Ssam form, collagenase expression inhibiting ability was slightly increased compared to raw extract, but the effect was insignificant compared to Ssam form fermentation method.

Therefore, the medicinal leaf ssam fermented extract according to the present invention was found to have an excellent anti-aging effect by effectively inhibiting the expression of collagenase to reduce collagen degradation in the skin.

Test Example 3 Anti-aging Effect Test II (Procollagen Production Promoting Effect Test)

The procollagen production ability of the extracts obtained in Comparative Examples 1 to 8 and Examples 1 and 2 was measured by comparing with vitamin C. Procollagen is a substance that induces collagen production and is necessary for collagen production and anti-aging, and vitamin C is known as an essential ingredient for collagen synthesis.

The test was performed by placing human fibroblasts at 5,000 cells / well in a 96-well microtiter plate containing Dulbecco's Modified Eagle's Media (DMEM) medium containing 2.5% fetal calf serum. Incubate until 90% growth. Thereafter, incubated in serum-free DMEM medium for 24 hours, and then each of the extracts of Comparative Examples 1 to 8, Examples 1 and 2, and vitamin C dissolved in serum-free DMEM medium for 10 hours at 10 ^-4 molarity. After that, the cell culture was collected. After 24 hours, the amount of free collagen in the medium was measured using the procollagen type-1 C-peptide EIA kit (MK101, Takara, Japan).

The degree of procollagen production in the untreated group was set to 100, and procollagen production in the group treated with the test substance was calculated, and the results are shown in Table 3 below.

TABLE 3

Test substance		Procollagen production level (%)
Untreated group		100
Vitamin c		120
Comparative Example 1	Rat Bean Extract	107
Comparative Example 2	Normal Fermented Rat Soybean Extract	97
Comparative Example 3	General Fermented Mulberry Leaf Extract	102
Comparative Example 4	Cornus Extract	105
Comparative Example 5	General Fermented Cornus Extract	98
Comparative Example 6	Normal Fermented Lower Lobe Extract	100
Comparative Example 7	Mulberry Leaf Mixed Fermented Root Bean Extract	110
Comparative Example 8	Lower lobe mixed fermented cornus extract	113
Example 1	Fermented Root Bean Extract of Mulberry Leaf Ssam	126
Example 2	Lower Lobe Ssam Fermented Cornus Extract	131

The higher the degree of procollagen production, the higher the degree of collagen production, thus preventing the formation of skin wrinkles. In Table 3, the mulberry leaf ssam fermented fermented soybean extract and lower leaf ssam fermented cornus extract according to the present invention promoted the production of procollagene more effectively than the raw product extracts (Comparative Examples 1 and 4) in vitro , and collagen. It was confirmed that the degree of promoting the production of procollagen is better than vitamin C, which is known as an essential ingredient for the synthesis. On the other hand, the general fermentation extract (Comparative Examples 2, 5) fermented without medicinal leaves showed a procollagen production level similar to that of the untreated group, showing little anti-aging effect. And in the case of simple mixed fermentation extract (Comparative Examples 7, 8), not the form of Ssam, the production of procollagen increased slightly compared to the raw extract, but the effect was insignificant compared to the form of fermentation of Ssam.

Therefore, the medicinal leaf ssam fermented extract according to the present invention was effectively promoted the production of procollagen to help the production of collagen in the skin was found to be excellent anti-aging effect.

Test Example 4 Whitening Effect Test (Measurement of Melanin Production Inhibition Using Pigment Cells)

The melanin production inhibitory ability of the extract obtained in Comparative Examples 1 to 8 and Examples 1 and 2 was measured in comparison with hydroquinone.

Mel-Ab cells derived from C57BL / 6 mice (Dooley, TP et al, Skin pharmacol, 7, pp 188-200) in DMEM with 10% fetal placental serum, 100 nM 12-O-tetradecanoyl Incubated at 37 ° C. and 5% CO ₂ in a medium to which phorbol (tetradecanoylphorbol) -13-acetate and 1 nM cholera toxin were added. The cultured Mel-Ab cells were detached with 0.25% trypsin-EDTA, the cells were incubated at a concentration of 10 ⁵ cells / well in 24-well plates, and then each test material was added for 3 consecutive days. And incubated. As a test substance, hydroquinone and the extracts of Comparative Examples 1 to 8 and Examples 1 and 2 were used at concentrations of 10 ppm, respectively. At this time, the hydroquinone was used as a positive control group. Then, the culture solution was removed, washed with PBS, dissolved in 1N sodium hydroxide, and measured for absorbance at 400 nm. Dooley's way).

Equation 2

Table 4

Test substance		Melanin production inhibition rate (%)
Untreated group		100
Hydroquinone (positive control)		41.1
Comparative Example 1	Rat Bean Extract	97.2
Comparative Example 2	Normal Fermented Rat Soybean Extract	99.4
Comparative Example 3	General Fermented Mulberry Leaf Extract	99.1
Comparative Example 4	Cornus Extract	101.2
Comparative Example 5	General Fermented Cornus Extract	100.3
Comparative Example 6	Normal Fermented Lower Lobe Extract	99.7
Comparative Example 7	Mulberry Leaf Mixed Fermented Root Bean Extract	65.9
Comparative Example 8	Lower lobe mixed fermented cornus extract	70.2
Example 1	Fermented Root Bean Extract of Mulberry Leaf Ssam	40.3
Example 2	Lower Lobe Ssam Fermented Cornus Extract	41.4

As shown in Table 4, the mulberry leaf ssam fermented fermented soybean extract and the lower leaf ssam fermented cornus extract of the present invention more effectively inhibited the production of melanin than raw extracts (Comparative Examples 1 and 4), hydroquinone and a known whitening substance. It was confirmed that the degree of inhibition of melanin production was similar. On the other hand, the general fermentation extract (Comparative Examples 2, 5) fermented without medicinal leaves was found to have almost no whitening effect at the same level as the untreated group. In addition, in the case of simple mixed fermentation extract (Comparative Examples 7, 8) rather than the form of Ssam, melanin production inhibition was slightly increased compared to the raw extract, but the effect was insignificant compared to the form of fermentation.

Therefore, the medicinal leaf ssam fermented extract according to the present invention was found to have an excellent whitening effect by effectively inhibiting melanin production in the skin.

Test Example 5 Irritation Test

In order to compare the usability of kojic acid, a known whitening substance, and the mulberry leaf fermented rat bean extract used as an active ingredient in the present invention, the degree of irritation such as stinging, burning, etc. was applied to 15 panelists sensitive to irritation such as stinging, burning, etc. Was tested.

Kojic acid (obtained from YM chemical) and mulberry leaf fermented rat bean extract (Example 1) were applied to each subject by randomly changing the left and right by 0.5ml, and scored between 0 and 3.0 in units of 0.1 points. It was made. The results are shown in Table 5 below.

<Evaluation Criteria>

0 to 0.4: no stimulation

0.5 to 1.0: slightly irritating

1.1 to 2.0: moderate stimulation

2.1 to 3.0: severe irritation

Table 5

Test substance		division
		Stinging	Burning	Average
Kojic acid		0.85	0.50	0.68
Comparative Example 1	Rat Bean Extract	0.65	0.44	0.55
Comparative Example 2	Normal Fermented Rat Soybean Extract	2.24	2.90	2.57
Comparative Example 3	General Fermented Mulberry Leaf Extract	2.45	3.00	2.73
Comparative Example 4	Cornus Extract	0.76	0.65	0.71
Comparative Example 5	General Fermented Cornus Extract	1.98	2.44	2.21
Comparative Example 6	Normal Fermented Lower Lobe Extract	1.90	2.04	1.97
Comparative Example 7	Mulberry Leaf Mixed Fermented Root Bean Extract	1.30	1.15	1.23
Comparative Example 8	Lower lobe mixed fermented cornus extract	1.19	1.40	1.30
Example 1	Fermented Root Bean Extract of Mulberry Leaf Ssam	0.14	0.22	0.18
Example 2	Lower Lobe Ssam Fermented Cornus Extract	0.42	0.30	0.36

As can be seen in Table 5, in the case of kojic acid, there was some degree of tingling, burning, there was a sense of irritation that can usually be felt slightly. In addition, raw extracts (Comparative Examples 1 and 4) have a slight sense of irritation, and general fermented extracts (Comparative Examples 2 and 5) fermented without medicinal leaves were found to have severe irritation. And, in the case of simple mixed fermentation extracts (Comparative Examples 7, 8) that are not in the form of ssam, although the degree of stimulation is lower than that of the general fermentation extract, it appears that there is a moderate degree of stimulation. There was a sense of irritation when using these extracts were found to be not good. On the other hand, the mulberry leaf ssam fermented fermented soybean extract and the lower leaf ssam fermented cornus extract used in the present invention was almost irritable because it is hardly felt both hot and stinging.

Therefore, the medicinal leaf ssam fermented extract of the present invention was confirmed that there is no irritation unlike kojic acid can provide a better feeling of use.

Test Example 6 Skin Moisturizing Test (Induction Test for Differentiation of Human Keratinocytes)

In order to confirm the skin barrier function and skin moisturizing ability of the extracts of Comparative Examples 1 to 8 and Examples 1 and 2, the cells were first attached to the bottom of the culture keratinocytes in a culture flask by absorbance test. , Comparative Examples 1 to 8, and extracts of Examples 1 to 2 were added to the culture solution as shown in Table 6 below, and cultured for 5 days until the cells grew about 70 to 80% of the floor area. The cells were harvested and washed with PBS (phosphate buffered saline), followed by 10 mM Tris-HCl (Tris-HCl) containing 2% Sodium Dodecyl Sulfate (SDS) and 20 mM Dithiothreitol (DTT). , pH 7.4) 1ml was added, and then boiled for 10 minutes after sonication (sonication) for 3 minutes. The precipitate was separated by centrifugation at 1200 rpm for 30 minutes and suspended again in 1 ml of PBS to measure absorbance at 340 nm.

Separately, a portion of the solution after the sonication was taken to measure the protein content, which was used as a reference for evaluating the degree of cell differentiation. Low calcium (0.03mM) treated group and high calcium (1.2mM) treated group as a negative / positive control, respectively, the test results performed by adding the test substance to the low calcium concentration is shown in Table 6 below.

Table 6

Test substance	Concentration	Differentiation capacity in keratinocytes (%)
Control	Low Ca 2+ (0.03 mM)	100
Control	High Ca 2+ (1.2 mM)	206
Rat bean extract (Comparative Example 1)	0.1 ppm	107
	0.05 ppm	96
General Fermented Rat Soybean Extract (Comparative Example 2)	0.1 ppm	110
	0.05 ppm	103
General Fermented Mulberry Leaf Extract (Comparative Example 3)	0.1 ppm	98
	0.05 ppm	91
Cornus Extract (Comparative Example 4)	0.1 ppm	112
	0.05 ppm	100
General Fermented Cornus Extract (Comparative Example 5)	0.1 ppm	121
	0.05 ppm	110
Normal Fermented Lower Leaf Extract (Comparative Example 6)	0.1 ppm	99
	0.05 ppm	92
Mixed Fermented Mulberry Leaf Extract of Mulberry Leaf (Comparative Example 7)	0.1 ppm	159
	0.05 ppm	139
Lower lobe mixed fermented cornus extract (Comparative Example 8)	0.1 ppm	166
	0.05 ppm	134
Mulberry leaf Ssam fermented rat eye bean extract (Example 1)	0.1 ppm	198
	0.05 ppm	180
Lower lobe Ssam fermented lactation extract (Example 2)	0.1 ppm	195
	0.05 ppm	183

As shown in Table 6 above, as a result of measuring the amount of CE (Cornified Envelop) produced during keratinocyte differentiation, comparing the effect of promoting cell differentiation, It can be seen that the mulberry leaf Ssam fermented fermented rat eye extract and the lower leaf Ssam fermented cornus extract promoted differentiation in keratinocytes more effectively than raw product extracts (Comparative Examples 1 and 4) and general fermented extracts (Comparative Examples 2 and 5). there was. Therefore, the medicinal leaf fermented extract according to the present invention was found to enhance skin barrier function and enhance skin moisturizing ability. In the case of simple mixed fermentation extracts (Comparative Examples 7, 8), which are not in the form of Ssam, the differentiation ability of keratinocytes was slightly increased compared to the raw extract, but the effect was insignificant compared to that of Ssam form.

Examples of the formulation of the composition are described below, but are not intended to limit the present invention but merely to be described in detail.

Formulation Example 1 Nutritional Cosmetics

Nutrients were prepared in a conventional manner according to the composition shown in the table below.

TABLE 7

ingredient	Content (% by weight)
Mulberry leaf Ssam fermented rat eye extract (Example 1)	5.0
Squalane	5.0
Beeswax	4.0
Polysorbate 60	1.5
Sorbitan sesquioleate	1.5
Liquid paraffin	0.5
Caprylic / Capric Triglycerides	5.0
glycerin	3.0
Butylene glycol	3.0
Propylene glycol	3.0
Carboxy Vinyl Polymer	0.1
Triethanolamine	0.2
Preservative, coloring, flavoring	Quantity
Purified water	Remaining amount
Sum	100

Formulation Example 2 Nutrition Cream

Nutritional creams were prepared in a conventional manner according to the composition described in the table below.

Table 8

ingredient	Content (% by weight)
Mulberry leaf Ssam fermented rat eye extract (Example 1)	5.0
Polysorbate 60	1.5
Sorbitan sesquioleate	0.5
PEG60 Cured Castor Oil	2.0
Liquid paraffin	10.0
Squalane	5.0
Caprylic / Capric Triglycerides	5.0
glycerin	5.0
Butylene glycol	3.0
Propylene glycol	3.0
Triethanolamine	0.2
Preservative, coloring, flavoring	Quantity
Purified water	Remaining amount
Sum	100

Formulation Example 3 Massage Cream

Massage cream was prepared in a conventional manner according to the composition described in the table below.

Table 9

ingredient	Content (% by weight)
Mulberry leaf Ssam fermented rat eye extract (Example 1)	5.0
Beeswax	10.0
Polysorbate 60	1.5
Sorbitan sesquioleate	0.8
PEG60 Cured Castor Oil	2.0
Liquid paraffin	40.0
Squalane	5.0
Caprylic / Capric Triglycerides	4.0
glycerin	5.0
Butylene glycol	3.0
Propylene glycol	3.0
Triethanolamine	0.2
Preservative, coloring, flavoring	Quantity
Purified water	Remaining amount
Sum	100

[Formulation Example 4] Pack

Packs were prepared by conventional methods according to the compositions described in the table below.

Table 10

ingredient	Content (% by weight)
Mulberry leaf Ssam fermented rat eye extract (Example 1)	5.0
Polyvinyl alcohol	13.0
Sodium Carboxymethyl Cellulose	0.2
glycerin	5.0
Allantoin	0.1
ethanol	6.0
PEG 12 nonylphenyl ether	0.3
Polysorbate 60	0.3
Preservative, coloring, flavoring	Quantity
Purified water	Remaining amount
Sum	100

Those skilled in the art to which the present invention pertains will be able to perform various applications and modifications within the scope of the present invention based on the above contents.

Claims (11)

1. A skin external preparation composition containing Ssam fermented extract prepared by fermenting by wrapping or covering natural products with medicinal leaves.
2. The method of claim 1, wherein the natural product is soybeans, cayenne meat, brown root, vigor, gamguk, guangjihwang, dried lacquer, licorice, health, dog, gwanja, red bark, gobon, ginseng, gallweed, fruit fruit, gojija, kwakyang, kwonbaek, Mandarin orange, gold and silver coins, gujeolcho, chrysanthemum, gilyeong, kkujija, nabokjak, male, kunggagyo, mung bean, antler, twill, multicolored, donkey, sugar citrus, daegye, soybean yellow, hemp , Cordyceps sinensis, tofu, ephedra, machi, manpyeongcho, ginseng, malt, mackmundong, quince, throat, cedar, radish, bark skin, peppermint, windproof, half, cabbage, white bran, baekduong, baekmi, baekbaek, sandalwood, baekryong, baekbokyeong, Baekbuja, Baekjain, Baekseolsaengcho, Baekjak, Baekji, Baekchul, Bokbunja, Bokryeong, Daebokpi, Rich, Leek, North Siho, Icepyeon, Apple Rock, Samsam, Sansam, Sansa, Sansuyu, Sanjang, Sanjoin, Sanchija, Sambaekcho, Shovel, Sangsan, Sangbaekpi, Sangsan, Sangup, Sergeant, Ginger, Seokchangpo, Seonhakcho, Seolchocho, Sesin, Lobules, Pine, Soyulgot, Sohyanghyang, Seedling seed, Sokdan, Matsutake, Horse riding, Shiho, New song, Night gate, Night view, Eoseongcho, Yeongyo, Yeonbap, Yeonjak, Yeogi, Yeonhwahwa, Ganoderma lucidum, Odu, Ogapi, Omija, Ogja, Osuyu, Ojak, Okmisu, Okjuk, Wasong, Yonggyu, Yongdamcho, Yonganyuk, Wooseol, Wonji, Wonhwa, Wolgamcho, Yuryeongseon, Yugeunpi, Rapeseed, Breeding Dragon, Eunsiho, Yinyanggak, Uiin, Motherwort, Ikjiin, Ginseng, Injin, Ildonggwi, One leaf Pendulum, cheongunggung, jawan, self-portrait, peony, remnant, low root skin, spirit, red bok ryok, red sesau, red cabbage, red peony, jeonho, gongpi, clove, carving, sculptor, stalk, jongyong, kill, phalanx, earth tree , Jimo, jibuja, jisil, jiyu, jihwang, jinbum, jingapi, pearl grass, dermis, teapot, changja, cheongung, cheonma, cheonmundong, cheoncho, cheongyuja, cheonnyeoncho, cheonsan dragon, cheonsan seolyeon, cheonhwabun, cheongho, excess , Choo, Gardenia, Blue Box, Quikhwa, Incense, Tarantula, Taxa, Tenza, Tobokyeong, Tosa, Seonggung Palace, Tongcho, Breakthrough , Green onion, pogongyoung, huangpu, balloon orchid, sewage, alliance, pedestrian, yangil gyuja, hyangbuja, balm, hyangchunja, hyangpo, Hyunsam, local herb, Hyunho color, hyungae, homaine, fenugreek, pumpkin, red pepper, red ginseng, Black tea mushroom, black tea Chukcho, safflower, Hwapi, golden, Astragalus, yellow lotus, yellow flower, yellow lumber, yellow and white, thick, black dog milk and rare skin composition, characterized in that at least one selected from the group consisting of.
3. The method of claim 1, wherein the medicinal leaves are mulberry leaves, lower leaves, twigs, bean leaves, bamboo leaves, mugwort leaves, mint leaves, ginseng leaves, green tea leaves, pumpkin leaves, persimmon leaves, loquat leaves, stone leaves, perilla leaves, mulberry leaves, and nuri Skin external composition, characterized in that at least one member selected from the group consisting of berry.
4. The composition for external application of skin according to claim 1, wherein the extract of Ssam fermented is contained in an amount of 0.001 to 30% by weight based on the total weight of the composition.
5. Use of the topical skin composition according to any one of claims 1 to 4 as an antioxidant.
6. Use as anti-aging of the external preparation composition for skin according to any one of claims 1 to 4.
7. Use of the external preparation composition for skin whitening as described in any one of Claims 1-4 for skin whitening.
8. Use of the external preparation composition for skin moisturizing as described in any one of Claims 1-4.
9. Boiling or steaming the washed and dried natural products for 30 minutes to 2 hours;

   Cooling the boiled or steamed natural product at room temperature for 30 minutes to 1 hour;

   Wrapping or covering the cooled natural products with medicinal leaves and placing them in an ong fermentation at room temperature for 4-7 days in the shade; And

   Removing and extracting medicinal leaves from the fermented natural products;

   Ssam fermentation extract manufacturing method comprising a.
10. 10. The method of claim 9, wherein the natural product is soybeans, cayenne meat, brown root, vigor, gamguk, guangjihwang, dried lacquer, licorice, health, dog, gwanja, red bark, gobon, ginseng, gallweed, fruit fruit, wolfberry, kwakyang, kwonbaek, Mandarin orange, gold and silver coins, gujeolcho, chrysanthemum, gilyeong, kkujija, nabokjak, male, kunggagyo, mung bean, antler, twill, multicolored, donkey, sugar citrus, daegye, soybean yellow, hemp , Cordyceps sinensis, tofu, ephedra, machi, manpyeongcho, ginseng, malt, mackmundong, quince, throat, cedar, radish, bark skin, peppermint, windproof, half, cabbage, white bran, baekduong, baekmi, baekbaek, sandalwood, baekryong, baekbokyeong, Baekbuja, Baekjain, Baekseolsaengcho, Baekjak, Baekji, Baekchul, Bokbunja, Bokryeong, Daebokpi, Rich, Leek, North Siho, Icepyeon, Apple Rock, Samsam, Sansam, Sansa, Sansuyu, Sanjang, Sanjoin, Sanchija, Sambaekcho, Shovel, Sangsan, Sangbaekpi, Sangsan, Sangup, Sergeant, Ginger, Seokchangpo, Seonhakcho, Seolchocho, Sesin, Lobules, Pine, Soyulgot, Sohyanghyang, Seedling seed, Sokdan, Matsutake, Horse riding, Shiho, New song, Night gate, Night view, Eoseongcho, Yeongyo, Yeonbap, Yeonjak, Yeogi, Yeonhwahwa, Ganoderma lucidum, Odu, Ogapi, Omija, Ogja, Osuyu, Ojak, Okmisu, Okjuk, Wasong, Yonggyu, Yongdamcho, Yonganyuk, Wooslung, Wonji, Wonhwa, Wolgamcho, Maengryon, Yu Geunpi, Rapeseed, Breeding Dragon, Eunsiho, Yin Yangkwa, Uiin, Motherwort, Ikjiin, Ginseng, Injin, Ildangwi, One Leaf Pendulum, cheongunggung, jawan, self-portrait, peony, remnant, low root skin, spirit, red bok ryok, red sesau, red cabbage, red peony, jeonho, gongpi, clove, carving, sculptor, stalk, jongyong, kill, phalanx, earth tree , Jimo, branch father, jisil, jiyu, jihwang, jinbum, jingapi, pearl grass, dermis, teapot, changza, cheongung, cheonma, cheonmun-dong, cheoncho, cheongyuja, cheonnyeoncho, cheonsan dragon, cheonsan seolyeon, cheonhwabun, cheongho, excess , Choo, Gardenia, Blue Box, Quikhwa, Incense, Tarantula, Taxa, Tenza, Tobokyeong, Tosa, Seonggung Palace, Tongcho, Breakthrough , Green onion, pogongyoung, huangpu, balloon orchid, sewage, alliance, pedestrian, yangil gyuja, hyangbuja, balm, hyangchunja, hyangpo, Hyunsam, local herb, Hyunho color, hyungae, homaine, fenugreek, pumpkin, red pepper, red ginseng, Black tea mushroom, black tea Chukcho, safflower, Hwapi, golden, Astragalus, yellow lotus, yellow flower, yellow lumber, yellow and white, hickory, black dog, and the production method of Ssam fermentation extract, characterized in that at least one selected from the group consisting of.
11. The method according to claim 9, wherein the medicinal leaves are mulberry leaves, lower leaves, twigs, bean leaves, bamboo leaves, mugwort leaves, peppermint leaves, ginseng leaves, green tea leaves, pumpkin leaves, persimmon leaves, loquat leaves, stone leaves, perilla leaves, mulberry leaves and nuri Method of producing Ssam fermented extract, characterized in that at least one selected from the group consisting of berry.