CN115177707B - Compound foot bath effervescent tablet and preparation method thereof - Google Patents

Compound foot bath effervescent tablet and preparation method thereof Download PDF

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CN115177707B
CN115177707B CN202210860319.6A CN202210860319A CN115177707B CN 115177707 B CN115177707 B CN 115177707B CN 202210860319 A CN202210860319 A CN 202210860319A CN 115177707 B CN115177707 B CN 115177707B
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chinese medicine
traditional chinese
medicine extract
foot bath
effervescent tablet
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CN115177707A (en
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包书茵
奥乌力吉
王秀兰
包晓华
孟和毕力格
苏都那布其
王秀枝
王爽
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Inner Mongolia Adisimon Pharmaceutical Co ltd
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Inner Mongolia Adisimon Pharmaceutical Co ltd
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Abstract

The application discloses a compound foot bath effervescent tablet, which comprises the following raw materials: the preparation comprises the following components of artemisia scoparia, dried ginger, phellodendron bark, white mountain, cacumen biotae, a lubricant, an alkali phase effervescing agent, an acid phase effervescing agent, polyvinyl alcohol, bentonite, chitosan, sodium dodecyl sulfate and glutaraldehyde; the weight ratio of the artemisia apiacea, the dried ginger, the phellodendron bark, the white mountain, the biota orientalis, the lubricant, the alkali phase effervescing agent, the acid phase effervescing agent, the polyvinyl alcohol, the bentonite, the chitosan, the acetic acid, the sodium dodecyl sulfonate and the glutaraldehyde is 10-20:10-20:10-20:1-5:1-5:2-6:1-5:1-5:1-4:1-4:1-2:1-3:0.1-1. The application also discloses a preparation method of the compound foot bath effervescent tablet.

Description

Compound foot bath effervescent tablet and preparation method thereof
Technical Field
The application relates to the technical field of foot bath effervescent tablets, in particular to a compound foot bath effervescent tablet and a preparation method thereof.
Background
At present, along with unreasonable application of antibiotics, increased application of hormones and various immunosuppressants, fungal infection diseases are increased year by year, but most of traditional antifungal medicines have the conditions of uncertain curative effect, large side effect or easy generation of drug resistance, so that more and more researchers now turn eyes to fungi inhibition researches of traditional Chinese medicine preparations. The Chinese medicinal antibacterial preparation is mostly composed of bitter and cold and toxic medicines, so that external means such as soaking, spraying, wet dressing, fumigation and the like are mostly adopted for the antibacterial application of the Chinese medicinal antibacterial preparation.
The traditional Chinese medicine bath therapy is a long-standing source in the treatment of traditional Chinese medicine fungal diseases, has the effects of clearing heat and detoxicating, moisturizing skin and relieving itching because of the numerous traditional Chinese medicines, is widely applied to the treatment of most of dermatophytes clinically, and becomes a daily method for treating dermatomycosis and preserving health and protecting health for people in recent years, but is difficult to popularize clinically because of complicated decoction procedures, complicated use processes, difficult mastery of dosage, use methods and external application time of patients.
The effervescent tablet takes acid source and alkali source as effervescent disintegrating agent, and reacts immediately after being put into water. The domestic research on the traditional Chinese medicine effervescent tablets is mainly on three types of oral effervescent tablets, oral effervescent tablets and vaginal effervescent tablets, has certain limitation on the use of the traditional Chinese medicine foot bath effervescent tablets, and has less research.
Compared with the traditional decoction, the foot bath effervescent tablet has the advantages of high bioavailability, convenient carrying and low cost. Therefore, it is necessary to search for the foot bath effervescent tablet with obvious curative effect, broad effect, small adverse reaction and convenient application.
Disclosure of Invention
The application aims to solve the defects in the prior art and provides a compound foot bath effervescent tablet and a preparation method thereof.
A compound foot bath effervescent tablet comprises the following raw materials in parts by mass: 10-20 parts of artemisia apiacea, 10-20 parts of dried ginger, 10-20 parts of phellodendron bark, 1-5 parts of white mountain, 1-5 parts of cacumen biotae, 2-6 parts of lubricant, 1-5 parts of alkali phase effervescing agent, 1-5 parts of acid phase effervescing agent, 1-4 parts of polyvinyl alcohol, 1-4 parts of bentonite, 1-2 parts of chitosan, 1-2 parts of acetic acid, 1-3 parts of sodium dodecyl sulfate and 0.1-1 part of glutaraldehyde.
Preferably, the lubricant is magnesium stearate.
Preferably, the alkaline phase effervescent agent is sodium bicarbonate.
Preferably, the acid phase effervescent agent is citric acid.
Artemisia scoparia, artemisia sphaerocephala, xiao Ai. Is prepared from Artemisia absinthium of Artemisia of Compositae by taking whole herb with flower as medicine. Harvesting for 7-8 months, and sun drying. Pungent and warm in nature. Has effects of eliminating dampness and killing parasites. It can be used for treating cholecystitis, expelling ascariasis, and enterobiasis.
The rhizoma Zingiberis is dried rhizome of rhizoma Zingiberis recens of Zingiberaceae. Collected in winter, removed fibrous root and silt, dried in the sun or dried at low temperature. The dried slices are dried in the sun or at low temperature. Pungent in flavor and warm in nature. It enters spleen, stomach, heart and lung meridians. Has the effects of warming middle energizer, dispelling cold, restoring yang, dredging collaterals, eliminating dampness, resolving phlegm, warming lung and resolving fluid retention. Is mainly used for treating cold pain in heart and abdomen, vomiting and diarrhea, weak cold pulse, cold-times dyspnea and cough, wind-cold-dampness arthralgia, yang deficiency vomiting, epistaxis and bleeding.
Cortex Phellodendri is dry bark of cortex Phellodendri or cortex Phellodendri of Rutaceae. The former is called "Chuan Bai Huang" and the latter is called "Gua Bai Huang". Bitter in flavor and cold in nature. Enter kidney, bladder and large intestine meridians. Has effects in clearing away heat and toxic materials, eliminating dampness, purging pathogenic fire, and clearing away deficiency heat. Can be used for treating damp-heat dysentery, jaundice, leukorrhagia, stranguria due to heat, tinea pedis, flaccidity, bone steaming, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema and pruritus.
White mountain, a name of Wanzhen, iron stone tea and white mirror. The preparation is prepared from Rhododendron simsii L.of Rhododendron of Ericaceae by taking branches and leaves as medicinal materials. Collected in summer and autumn and dried in the sun. Sour and pungent taste and warm nature. Enters the heart, lung and large intestine meridians. It is toxic. Has effects in dispelling pathogenic wind, dredging collaterals, regulating menstruation, relieving pain, eliminating phlegm, and relieving cough. Can be used for treating chronic tracheitis, rheumatalgia, lumbago, dysmenorrhea, and puerperal arthralgia.
The cacumen Platycladi is tender branch and leaf of Platycladus orientalis of Cupressaceae. Bitter and astringent, and slightly cold in nature. Enter the lung, liver and large intestine. Has effects of cooling blood, stopping bleeding, promoting hair growth, and blackening hair. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, hemorrhage, alopecia due to blood heat, and premature gray hair.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch and folium Platycladi, adding into 40-60% ethanol water solution, ultrasonic extracting for 2-4 times for 20-40min each time with ultrasonic frequency of 10-20kHz and ultrasonic power of 300-400W, mixing the filtrates, concentrating to obtain extract, drying, and pulverizing to obtain Chinese medicinal extract;
(2) Dividing the traditional Chinese medicine extract into three parts, and sequentially naming the three parts as a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract;
(3) Adding a lubricant and an alkali phase effervescent agent into the first traditional Chinese medicine extract, and uniformly mixing to obtain a prefabricated material a; adding a lubricant and an acid phase effervescent agent into the second traditional Chinese medicine extract, and uniformly mixing to obtain a prefabricated material b;
(4) Adding the third traditional Chinese medicine extract, bentonite, chitosan, acetic acid and sodium dodecyl sulfonate into the polyvinyl alcohol aqueous solution, stirring, adding glutaraldehyde, continuously stirring for 10-20min at 30-40 ℃, and cooling to obtain a prefabricated material c;
(5) And uniformly mixing the premix a, the premix b and the prefabricated material c, and tabletting to obtain the compound foot bath effervescent tablet.
Preferably, in the ultrasonic extraction process of the step (1), the feed liquid ratio is 1:10-15.
Preferably, in the step (2), the mass percentage of the first traditional Chinese medicine extract in the traditional Chinese medicine extract is 30-40%.
Preferably, in the step (2), the second traditional Chinese medicine extract accounts for 30-40% of the traditional Chinese medicine extract by mass.
Preferably, in the step (3), the mass ratio of the lubricant used for the pre-material a to the lubricant used for the pre-material b is 1-3:1-3.
Preferably, in step (4), the system is stirred until the volume of the system increases by a factor of 1.5 to 2.5 times the initial volume before glutaraldehyde is added.
Preferably, in the step (4), the preform c is obtained by means of liquid nitrogen cooling.
The technical effects of the application are as follows:
according to the application, the artemisia apiacea, the dried ginger, the phellodendron, the white mountain and the biota orientalis are compounded, ethanol extraction is adopted, and the ultrasonic conditions are controlled, so that the extraction efficiency is high, and the obtained traditional Chinese medicine extract has a remarkable fungus inhibition effect.
The traditional Chinese medicine extracts are adopted to prepare the prefabricated material a and the prefabricated material b respectively, so that after the effervescent tablet obtained by tabletting is added into water, the traditional Chinese medicine extracts are rapidly disintegrated and released, the traditional Chinese medicine extracts are rapidly released, the use is extremely convenient, the fungus inhibition effect is obvious, but the fungus inhibition effect is poor at the later stage of soaking along with the prolonged soaking time of foot bath.
Therefore, the application adopts the hydrogen bonding action between PVA, chitosan and bentonite, and is matched with sodium dodecyl sulfonate for foaming, and in-situ gelation is promoted by liquid nitrogen cooling, so that the application not only can provide a great load channel and specific surface area, but also has excellent adsorption performance on traditional Chinese medicine extract, high load capacity and poor structural stability. Therefore, the prefabricated material c prepared by crosslinking glutaraldehyde has good structural stability, can effectively and slowly release the active ingredient, simultaneously forms an internal through hole by freezing ice crystals in the prefabricated material c through liquid nitrogen cooling, provides a rich channel for water transmission, has extremely high water transmission speed, can realize quick water transmission, and can ensure that the water is continuously transmitted to the inside of a load matrix after the water drives the active ingredient to be extruded.
According to the application, the prefabricated material c, the prefabricated material a and the prefabricated material b are tabletted, the prefabricated material a and the prefabricated material b are rapidly disintegrated when meeting water, the prefabricated material c is released into foot bath liquid, the residual traditional Chinese medicine extracting solution can be slowly released, the antibacterial and sterilizing effects of the whole foot bath process are effectively ensured, meanwhile, a large amount of air bubbles are introduced into the prefabricated material c, the structural hardness is moderate, the prefabricated material c is trampled in the foot soaking process, the sole of a foot can be effectively massaged, the blood circulation of the sole of the foot is promoted, and the active ingredients in the prefabricated material c can be rapidly absorbed by the skin of the foot in the foot treading and massaging process, so that the antibacterial and sterilizing effects are obvious.
Drawings
FIG. 1 is an SEM photograph of the preform c obtained in example 5.
Fig. 2 is a graph comparing the instant antibacterial rate, the tested foot-increasing rate and the 12-hour actual antibacterial rate of the compound foot-bath effervescent tablets obtained in the example 5 and the comparative examples 1-2.
Detailed Description
The application is further illustrated below in connection with specific embodiments.
Example 1
A compound foot bath effervescent tablet comprises the following raw materials: 10kg of artemisia apiacea, 10kg of dried ginger, 10kg of phellodendron bark, 1kg of white mountain, 1kg of cacumen biotae, 2kg of magnesium stearate, 1kg of sodium bicarbonate, 1kg of citric acid, 1kg of polyvinyl alcohol, 1kg of bentonite, 1kg of chitosan, 1kg of acetic acid, 1kg of sodium dodecyl sulfate and 0.1kg of glutaraldehyde.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 40% ethanol water solution, wherein the ratio of the liquid to the solid is controlled to be 1:10, carrying out ultrasonic extraction for 2 times, wherein each ultrasonic time is 20min, ultrasonic frequency is 10kHz, ultrasonic power is 300W, combining the filtrates after each extraction, concentrating to obtain extract, drying, and pulverizing to obtain traditional Chinese medicine extract;
(2) Dividing the traditional Chinese medicine extract into three parts, namely a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract in sequence, wherein the weight percentage of the first traditional Chinese medicine extract in the traditional Chinese medicine extract is 30%, and the weight percentage of the second traditional Chinese medicine extract in the traditional Chinese medicine extract is 30%;
(3) Adding 1kg of magnesium stearate and sodium bicarbonate into the first traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material a; adding 1kg of magnesium stearate and citric acid into the second traditional Chinese medicine extract, uniformly mixing, and sieving with an 80-mesh sieve to obtain a prefabricated material b;
(4) Adding a third traditional Chinese medicine extract, bentonite, chitosan, acetic acid and sodium dodecyl sulfate into 10kg of 10% polyvinyl alcohol aqueous solution by mass fraction, stirring at a high speed of 10000r/min until the volume of the system expands 1.5 times, adding glutaraldehyde, continuously stirring at 30 ℃ for 10min, and cooling by adopting liquid nitrogen to obtain a prefabricated material c;
(5) And uniformly mixing the premix a, the premix b and the prefabricated material c, and tabletting to obtain the compound foot bath effervescent tablet.
Example 2
A compound foot bath effervescent tablet comprises the following raw materials: 20kg of artemisia apiacea, 20kg of dried ginger, 20kg of phellodendron bark, 5kg of white mountain, 5kg of cacumen biotae, 6kg of magnesium stearate, 5kg of sodium bicarbonate, 5kg of citric acid, 4kg of polyvinyl alcohol, 4kg of bentonite, 2kg of chitosan, 2kg of acetic acid, 3kg of sodium dodecyl sulfate and 1kg of glutaraldehyde.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 60% ethanol water solution, wherein the ratio of the liquid to the solid is controlled to be 1:15, carrying out ultrasonic extraction for 4 times, wherein the ultrasonic time is 40min, the ultrasonic frequency is 20kHz, the ultrasonic power is 400W, combining the filtrates after each extraction, concentrating to obtain an extract, drying, and pulverizing to obtain a traditional Chinese medicine extract;
(2) Dividing the traditional Chinese medicine extract into three parts, and sequentially naming the three parts as a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract, wherein the first traditional Chinese medicine extract accounts for 40% of the traditional Chinese medicine extract by mass, and the second traditional Chinese medicine extract accounts for 40% of the traditional Chinese medicine extract by mass;
(3) Adding 3kg of magnesium stearate and sodium bicarbonate into the first traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material a; adding 3kg of magnesium stearate and citric acid into the second traditional Chinese medicine extract, uniformly mixing, and sieving with an 80-mesh sieve to obtain a prefabricated material b;
(4) Adding a third traditional Chinese medicine extract, bentonite, chitosan, acetic acid and sodium dodecyl sulfate into 20kg of 20% polyvinyl alcohol aqueous solution with mass fraction, stirring at a high speed of 20000r/min until the volume of the system expands 2.5 times, adding glutaraldehyde, continuously stirring at 40 ℃ for 20min, and cooling by adopting liquid nitrogen to obtain a prefabricated material c;
(5) And uniformly mixing the premix a, the premix b and the prefabricated material c, and tabletting to obtain the compound foot bath effervescent tablet.
Example 3
A compound foot bath effervescent tablet comprises the following raw materials: 12kg of artemisia apiacea, 17kg of dried ginger, 12kg of phellodendron bark, 4kg of white mountain, 2kg of cacumen biotae, 4kg of magnesium stearate, 4kg of sodium bicarbonate, 2kg of citric acid, 2.34kg of polyvinyl alcohol, 3kg of bentonite, 1.3kg of chitosan, 1.8kg of acetic acid, 1.5kg of sodium dodecyl sulfate and 0.8kg of glutaraldehyde.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 45% ethanol water solution, wherein the ratio of the liquid to the solid is controlled to be 1:13, carrying out ultrasonic extraction for 2 times, wherein each ultrasonic time is 35min, ultrasonic frequency is 13kHz, ultrasonic power is 370W, combining the filtrates after each extraction, concentrating to obtain extract, drying, and pulverizing to obtain traditional Chinese medicine extract;
(2) Dividing the traditional Chinese medicine extract into three parts, namely a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract in sequence, wherein the first traditional Chinese medicine extract accounts for 33% of the traditional Chinese medicine extract by mass, and the second traditional Chinese medicine extract accounts for 36% of the traditional Chinese medicine extract by mass;
(3) Adding 1.5kg of magnesium stearate and sodium bicarbonate into the first traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material a; adding 2.5kg of magnesium stearate and citric acid into the second traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material b;
(4) Adding a third traditional Chinese medicine extract, bentonite, chitosan, acetic acid and sodium dodecyl sulfate into 13kg of a polyvinyl alcohol aqueous solution with mass fraction of 18%, stirring at a high speed of 12000r/min until the volume of the system expands 2.2 times, adding glutaraldehyde, continuously stirring at 33 ℃ for 17min, and cooling by adopting liquid nitrogen to obtain a prefabricated material c;
(5) And uniformly mixing the premix a, the premix b and the prefabricated material c, and tabletting to obtain the compound foot bath effervescent tablet.
Example 4
A compound foot bath effervescent tablet comprises the following raw materials: 18kg of artemisia apiacea, 13kg of dried ginger, 18kg of phellodendron bark, 2kg of white mountain, 4kg of cacumen biotae, 4kg of magnesium stearate, 2kg of sodium bicarbonate, 4kg of citric acid, 2.04kg of polyvinyl alcohol, 2kg of bentonite, 1.7kg of chitosan, 1.4kg of acetic acid, 2.5kg of sodium dodecyl sulfate and 0.4kg of glutaraldehyde.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 55% ethanol water solution, wherein the ratio of the materials to the liquid is controlled to be 1:11, carrying out ultrasonic extraction for 4 times, wherein each ultrasonic time is 25min, ultrasonic frequency is 17kHz, ultrasonic power is 330W, combining the filtrates after each extraction, concentrating to obtain extract, drying, and pulverizing to obtain traditional Chinese medicine extract;
(2) Dividing the traditional Chinese medicine extract into three parts, and sequentially naming the three parts as a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract, wherein the first traditional Chinese medicine extract accounts for 37% of the traditional Chinese medicine extract by mass, and the second traditional Chinese medicine extract accounts for 34% of the traditional Chinese medicine extract by mass;
(3) Adding 2.5kg of magnesium stearate and sodium bicarbonate into the first traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material a; adding 1.5kg of magnesium stearate and citric acid into the second traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material b;
(4) Adding a third traditional Chinese medicine extract, bentonite, chitosan, acetic acid and sodium dodecyl sulfate into 17kg of 12% polyvinyl alcohol aqueous solution by mass fraction, stirring at a high speed of 18000r/min until the volume of the system expands 1.8 times, adding glutaraldehyde, continuously stirring at 37 ℃ for 12min, and cooling by adopting liquid nitrogen to obtain a prefabricated material c;
(5) And uniformly mixing the premix a, the premix b and the prefabricated material c, and tabletting to obtain the compound foot bath effervescent tablet.
Example 5
A compound foot bath effervescent tablet comprises the following raw materials: 15kg of artemisia apiacea, 15kg of dried ginger, 15kg of phellodendron bark, 3kg of white mountain, 3kg of cacumen biotae, 4kg of magnesium stearate, 3kg of sodium bicarbonate, 3kg of citric acid, 2.25kg of polyvinyl alcohol, 2.5kg of bentonite, 1.5kg of chitosan, 1.6kg of acetic acid, 2kg of sodium dodecyl sulfate and 0.6kg of glutaraldehyde.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 50% ethanol water solution, wherein the ratio of the liquid to the solid is controlled to be 1:12, carrying out ultrasonic extraction for 3 times, wherein each ultrasonic time is 30min, ultrasonic frequency is 15kHz, ultrasonic power is 350W, combining the filtrates after each extraction, concentrating to obtain extract, drying, and pulverizing to obtain traditional Chinese medicine extract;
(2) Dividing the traditional Chinese medicine extract into three parts, and sequentially naming the three parts as a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract, wherein the first traditional Chinese medicine extract accounts for 35% of the traditional Chinese medicine extract by mass, and the second traditional Chinese medicine extract accounts for 35% of the traditional Chinese medicine extract by mass;
(3) Adding 2kg of magnesium stearate and sodium bicarbonate into the first traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material a; adding 2kg of magnesium stearate and citric acid into the second traditional Chinese medicine extract, uniformly mixing, and sieving with an 80-mesh sieve to obtain a prefabricated material b;
(4) Adding a third traditional Chinese medicine extract, bentonite, chitosan, acetic acid and sodium dodecyl sulfate into 15kg of 15% polyvinyl alcohol aqueous solution with mass fraction, stirring at a high speed of 15000r/min until the volume of the system expands 2 times, adding glutaraldehyde, continuously stirring at 35 ℃ for 15min, and cooling by adopting liquid nitrogen to obtain a prefabricated material c;
(5) And uniformly mixing the premix a, the premix b and the prefabricated material c, and tabletting to obtain the compound foot bath effervescent tablet.
The prepared material c obtained in the example 5 is freeze-dried, then is subjected to electron microscope scanning, and the obtained SEM spectrogram is shown in figure 1, frozen ice crystals are formed in the prepared material c through liquid nitrogen cooling, and then are gasified through freeze-drying, so that pores generated by growth and extrusion of the ice crystals are left, and a rich channel is provided for water transmission.
Comparative example 1
A compound foot bath effervescent tablet comprises the following raw materials: 15kg of artemisia apiacea, 15kg of dried ginger, 15kg of phellodendron bark, 3kg of white mountain, 3kg of biota orientalis, 4kg of magnesium stearate, 3kg of sodium bicarbonate and 3kg of citric acid.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 50% ethanol water solution, wherein the ratio of the liquid to the solid is controlled to be 1:12, carrying out ultrasonic extraction for 3 times, wherein each ultrasonic time is 30min, ultrasonic frequency is 15kHz, ultrasonic power is 350W, combining the filtrates after each extraction, concentrating to obtain extract, drying, and pulverizing to obtain traditional Chinese medicine extract;
(2) Dividing the traditional Chinese medicine extract into three parts, and sequentially naming the three parts as a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract, wherein the first traditional Chinese medicine extract accounts for 35% of the traditional Chinese medicine extract by mass, and the second traditional Chinese medicine extract accounts for 35% of the traditional Chinese medicine extract by mass;
(3) Adding 2kg of magnesium stearate and sodium bicarbonate into the first traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material a; adding 2kg of magnesium stearate and citric acid into the second traditional Chinese medicine extract, uniformly mixing, and sieving with an 80-mesh sieve to obtain a prefabricated material b;
(4) Mixing premix a, premix b and the third traditional Chinese medicine extract uniformly, and tabletting to obtain the compound foot bath effervescent tablet.
Comparative example 2
A compound foot bath effervescent tablet comprises the following raw materials: 15kg of artemisia apiacea, 15kg of dried ginger, 15kg of phellodendron bark, 3kg of white mountain, 3kg of cacumen biotae, 4kg of magnesium stearate, 3kg of sodium bicarbonate, 3kg of citric acid, 2.25kg of polyvinyl alcohol, 2.5kg of bentonite and 2kg of sodium dodecyl sulfate.
The preparation method of the compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 50% ethanol water solution, wherein the ratio of the liquid to the solid is controlled to be 1:12, carrying out ultrasonic extraction for 3 times, wherein each ultrasonic time is 30min, ultrasonic frequency is 15kHz, ultrasonic power is 350W, combining the filtrates after each extraction, concentrating to obtain extract, drying, and pulverizing to obtain traditional Chinese medicine extract;
(2) Dividing the traditional Chinese medicine extract into three parts, and sequentially naming the three parts as a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract, wherein the first traditional Chinese medicine extract accounts for 35% of the traditional Chinese medicine extract by mass, and the second traditional Chinese medicine extract accounts for 35% of the traditional Chinese medicine extract by mass;
(3) Adding 2kg of magnesium stearate and sodium bicarbonate into the first traditional Chinese medicine extract, uniformly mixing, and sieving with a 80-mesh sieve to obtain a prefabricated material a; adding 2kg of magnesium stearate and citric acid into the second traditional Chinese medicine extract, uniformly mixing, and sieving with an 80-mesh sieve to obtain a prefabricated material b;
(4) Adding a third traditional Chinese medicine extract, bentonite and sodium dodecyl sulfate into 15kg of 15% polyvinyl alcohol aqueous solution with mass fraction, stirring at a speed of 15000r/min at a high speed until the volume of the system expands 2 times, and cooling by adopting liquid nitrogen to obtain a prefabricated material c;
(5) And uniformly mixing the premix a, the premix b and the prefabricated material c, and tabletting to obtain the compound foot bath effervescent tablet.
The corresponding instrument was wiped with 75% alcohol and irradiated with ultraviolet light for 2 hours. Taking a disposable sterile plastic bag to be sleeved in a foot bath basin, respectively adding the compound foot bath effervescent tablets obtained in the example 5 and the comparative examples 1-2 into the foot bath basin, adding 1L of sterile warm water (50 ℃), standing until the water temperature is 40+/-1 ℃, immersing the test foot in the medicinal liquid, completely immersing the sampling part in the medicinal liquid, and soaking and washing for 20 minutes. The subject properly moves the foot and toe joints for 30 seconds every 5 minutes during the soak. And finally, wiping the skin with a sterile dressing, and sleeving a sterile foot sleeve by an operator according to a sterile principle after sampling.
The operator takes a cotton swab containing the sampling liquid, holds the cap end, and smears the swab 2 times at the webbings (each webbings has an area of about 2 cm) 2 Totaling 16cm 2 ) Taking sterile standard plate (3×4 cm) and respectively placing at instep and plantar metatarsal bones, respectively, and repeatedly rubbing with swab cotton head for 2 times, about 48cm 2 The subjects were then instructed to apply the ankle dorsal extension to the posterior lateral skin fold of the heel (around the near achilles tendon stop) for 2 passes over an area of about 6cm 2 In the process of smearing, the swab is continuously rotated to ensure that the cotton swab head is fully contacted with the skin, and the total sampling area is about 70cm 2 . Alcohol burner external flame burning nozzle and then inserting wiperSub-sealing and coding inspection.
1. Sensitization evaluation
After foot bath, the patient was asked for skin feel, and the local skin reaction was observed for 48 hours, and the sensitization response rate was calculated. The sensitization rate of example 5 was 0, the sensitization rate of comparative example 1 was 26.67%, and the sensitization rate of comparative example 2 was 10%.
The inventors consider that: the compound foot bath effervescent tablet obtained in the comparative example 1 is rapidly disintegrated in water, so that the concentration of the traditional Chinese medicine extract in water is rapidly increased to the highest level, and the traditional Chinese medicine extract contains partial sensitization components, so that skin allergy of sensitive people is caused. And bentonite is adopted in the compound foot bath effervescent tablet obtained in the comparative example 2 for compatibility, and a slow release effect is formed on the traditional Chinese medicine extract, so that the sensitization reaction rate of the compound foot bath effervescent tablet obtained in the comparative example 2 is lower than that of the comparative example 1. In the preparation process of the embodiment 5, the prefabricated material c is adopted as a slow release component, so that part of the traditional Chinese medicine extract is slowly released, the initial concentration of the compound foot bath effervescent tablet added into water is inferior to that of the comparative example, and the allergic reaction of a subject is avoided.
2. Immediate bacteriostasis rate
And calculating the instant bacteriostasis rate according to the data before and after soaking and washing of each group, and reflecting the instant bacteriostasis effect.
Immediate antibacterial ratio = (number of colonies before soaking-number of colonies after soaking)/(number of colonies before soaking ×100%)
3. Test foot enrichment rate
According to the colony number after soaking and washing and the colony number after soaking and washing for 12 hours, the bacterial increment rate of the tested foot is calculated, and the delay antibacterial effect is reflected.
Test foot enrichment ratio= (number of colonies after soaking and washing 12 h-number of colonies after soaking and washing)/(number of colonies after soaking and washing×100%)
4. 12h actual antibacterial rate
According to the colony number of each group of the bacteria after soaking and washing and the colony number before soaking and washing, calculating the actual antibacterial rate of 12 hours, and reflecting the antibacterial effect of the time interval of the medication.
12h actual antibacterial ratio= (number of colonies before washing by bubbling-number of colonies after washing by bubbling)/(number of colonies before washing by bubbling ×100%)
The instant antibacterial rate, the tested foot-increasing rate and the 12-hour practical antibacterial rate are shown in figure 2, the instant antibacterial rate of the compound foot-bath effervescent tablet obtained in the example 5 is slightly lower than that of the comparative example, but the tested foot-increasing rate and the 12-hour practical antibacterial rate are far better than those of the comparative example. The inventors consider that: the preparation process of the embodiment 5 adopts the prefabricated material c as a slow release component, so that part of traditional Chinese medicine extract is slowly released, the initial concentration of the compound foot bath effervescent tablet added into water is not the same as that of the comparative example, but along with the extension of the soaking and washing process, the prefabricated material c can be partially adhered to feet, so that the long-acting slow release can be realized, the antibacterial effect is improved, the tested foot enrichment rate is reduced, and the practical antibacterial rate is increased by 12 hours.
The foregoing is only a preferred embodiment of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art, who is within the scope of the present application, should make equivalent substitutions or modifications according to the technical scheme of the present application and the inventive concept thereof, and should be covered by the scope of the present application.

Claims (1)

1. A compound foot bath effervescent tablet for bacteriostasis and sterilization is characterized by comprising the following components:
the weight ratio of the artemisia apiacea, the dried ginger, the phellodendron bark, the white mountain, the biota orientalis, the lubricant, the alkali phase effervescing agent, the acid phase effervescing agent, the polyvinyl alcohol, the bentonite, the chitosan, the acetic acid, the sodium dodecyl sulfonate and the glutaraldehyde is 10-20:10-20:10-20:1-5:1-5:2-6:1-5:1-5:1-4:1-4:1-2:1-3:0.1-1;
the preparation method of the antibacterial and bactericidal compound foot bath effervescent tablet comprises the following steps:
(1) Pulverizing herba Artemisiae Scopariae, zingiberis rhizoma, cortex Phellodendri, radix et rhizoma Rhei Franch, and folium Platycladi, adding into 40-60% ethanol water solution, and controlling the feed-liquid ratio to be 1:10-15, performing ultrasonic extraction for 2-4 times, wherein each time the ultrasonic frequency is 10-20kHz and the ultrasonic power is 300-400W, mixing the filtrates after each extraction, concentrating to obtain extract, drying, and pulverizing to obtain Chinese medicinal extract;
(2) Dividing the traditional Chinese medicine extract into three parts, and sequentially naming the three parts as a first traditional Chinese medicine extract, a second traditional Chinese medicine extract and a third traditional Chinese medicine extract;
wherein the first traditional Chinese medicine extract accounts for 30-40% of the traditional Chinese medicine extract by mass, the second traditional Chinese medicine extract accounts for 30-40% of the traditional Chinese medicine extract by mass, and the balance is the third traditional Chinese medicine extract;
(3) Adding magnesium stearate and sodium bicarbonate into the first Chinese medicinal extract, and mixing to obtain a preformaThe method comprises the steps of carrying out a first treatment on the surface of the Adding magnesium stearate and citric acid into the second Chinese medicinal extract, and mixing to obtain preformb；
(4) Adding the third Chinese medicinal extract, bentonite, chitosan, acetic acid, and sodium dodecyl sulfate into polyvinyl alcohol water solution, stirring until the system volume is increased to 1.5-2.5 times of the initial volume, adding glutaraldehyde, stirring at 30-40deg.C for 10-20min, and cooling with liquid nitrogen to obtain prefabricated materialc；
(5) Premix compoundaPremix compoundbPrefabricated materialcMixing uniformly, tabletting to obtain the antibacterial and bactericidal compound foot bath effervescent tablet.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040092496A (en) * 2003-04-24 2004-11-04 김정태 Dried laver food added chiness medicinal herbs and the processing method thereof
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KR20060033070A (en) * 2004-10-14 2006-04-19 김태균 Hip-bath compositions for treatment of herorrhoids or gynecological diseases, and hip-bath bag containing it
WO2011126295A2 (en) * 2010-04-06 2011-10-13 (주)아모레퍼시픽 Wrapping fermentation method using medicinal leaves, and composition for external skin application using same
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