KR20080090806A - Cosmetic composition containing natural product extracts for restoring skin condition - Google Patents

Abstract

A cosmetic composition comprising a natural material of Vitis coignetiae seeds, Scutellaria baicalensis, green tea seeds, rice bran, Metaplexis japonica, Taraxacum platycarpum, Astragalus membranaceus, Umbilicaria esculenta, Agaricus blazei Murill, Rosa chinensis, Gynostemma pentaphyllum, Camellia japonica pericarps, and vegetable worms is provided to be more environment-friendly and lower-toxic than a cosmetic composition comprising chemical synthetic ingredients and show excellent skin condition improving effect. A cosmetic composition for skin whitening comprises 0.01-10 wt.% of an extract of at least one material selected from the group consisting of Vitis coignetiae seeds, Scutellaria baicalensis, green tea seeds, rice bran, Metaplexis japonica leaves, Metaplexis japonica roots, and Metaplexis japonica fruits. A cosmetic composition for skin moisturizing comprises 0.01-10 wt.% of an extract of at least one material selected from the group consisting of Taraxacum platycarpum, Astragalus membranaceus, Umbilicaria esculenta, Agaricus blazei Murill, Rosa chinensis, and Gynostemma pentaphyllum. An anti-atopic cosmetic composition comprises 0.01-10 wt.% of an extract of at least one material selected from the group consisting of Metaplexis japonica leaves, green tea seeds, Scutellaria baicalensis, Taraxacum platycarpum, Agaricus blazei Murill, Gynostemma pentaphyllum, Umbilicaria esculenta, and Camellia japonica pericarps. A cosmetic composition for blocking UV comprises 0.01-10 wt.% of an extract of at least one material selected from the group consisting of Taraxacum platycarpum, Astragalus membranaceus, Agaricus blazei Murill, green tea seeds, vegetable worms, and Camellia japonica pericarps.

Description

Cosmetic composition containing natural product extracts and having skin improvement effect {Cosmetic composition containing natural product extracts for restoring skin condition}

Figure 1 is a graph showing the results of measuring the inhibition rate of tyrosinase in vitro (in vitro) to find out the natural product showing the whitening effect.

Figure 2 is a photograph taken 24 hours after the natural product showing the whitening effect to the rat.

Figure 3 is a photograph taken 24 hours after the natural product showing the whitening effect to the rat.

Figure 4 is a photograph of the whitening effect after applying the extract of the leaves of gourd, gourd root and gourds on the rat.

FIG. 5 is a photograph taken after combining two kinds of natural products showing a whitening effect to a mouse. FIG.

6 is a graph showing the moisturizing effect of natural products.

Figure 7 is a graph showing the number of scratches for 1 hour after applying the natural product and the material that induces itching in rats to see if the natural product is effective for atopy.

FIG. 8 is a photograph of a state in which a damaged skin is exposed to ultraviolet rays and then recovered after treating camellia skin (KAP).

Figure 9 is a photograph of a state in which the damaged skin after exposure to ultraviolet rays recovered by the treatment of natural products.

The present invention relates to a cosmetic composition for improving skin condition containing natural products as an active ingredient and excellent in whitening, moisturizing, anti-atopic, and sunscreen effects. More specifically, the cosmetic composition containing extracts such as maroon seeds, golden, green tea seeds, rice bran, gourd green leaf, gourd green root, gourd green fruit, dandelion, astragalus, stone, agaricus, changchunhwa, dole, camellia peel, cordyceps, etc. as active ingredients It is about.

The pigment in the skin is synthesized in the melanosomes of melanin pesos, and this mechanism begins by the conversion of amino acids and L-tyrosine to 3,4-dihydroxyphenylalanine (L-dopa). do. Tyrosine is oxidized to dopa and dopaquinone by tyrosinase in melanocytes. Dopaquinone is then melanine by polymerization to dopachrome, 5,6-dihydroxyindole, indole-5,6-quinone. Is known to produce Therefore, it is possible to block the production of melanin by inhibiting the activity of tyrosinase, which acts when melanin is synthesized in melanocytes.

Formulations such as hydroquinone, alpha arbutin, kojic acid and the like are used as agents for inhibiting the activity of tyrosinase.

Hydroquinone is currently the most powerful bleaching agent, and is currently the most widely used in whitening products all over the world, and it is also excellent in treating skin problems such as spots, freckles, and blotch. However, there is a problem that this component can cause skin cancer, and has been reported as a dangerous substance by the US Food and Drug Administration (FDA), which has been the subject of harmful debate between the industry and the FDA.

Meanwhile, another arranging whitening ingredient is alpha arbutin. This ingredient is a synthetic whitening ingredient developed in Japan and used as a main ingredient in Japanese whitening cosmetics. The advantage is that it is materially stable, effective, nontoxic and similar in structure to hydroquinone, so it has a whitening effect comparable to hydroquinone, but it is expensive.

There is also kojic acid, which is widely used in cosmetics for its excellent whitening effect. It has a weaker discoloring effect than hydroquinone preparation, but has good stability, no irritation to the skin and strong whitening effect. However, when applied to the skin may cause contact allergies, sensitive skin has the disadvantage of having to pay attention, and recently, the possibility of carcinogenesis has been raised.

Accordingly, the present inventors have studied to find a natural product with low toxicity and low toxicity while providing a whitening effect by inhibiting the activity of tyrosinase, thereby improving the skin condition. It was found that the extracts of the roots of the cauliflower and the fruits of the cauliflower were very excellent in the skin whitening effect.

In addition, green tea seeds, gourd green leaf, dandelion, Astragalus, stone, Agaricus, Changchunhwa, Dole, Camellia peel, Cordyceps sinensis extracts such as moisturizing, anti-atopy, sunscreen effect was found to complete the present invention.

Accordingly, it is an object of the present invention to provide a cosmetic composition having excellent skin whitening, moisturizing, anti-atopic and sunscreen effects by using natural products.

In order to achieve the above object, the present invention contains one or more extracts selected from the group consisting of beetroot seeds, golden, green tea seeds, rice bran, gourd green leaf, gourd green root and gourd green fruit as an active ingredient, cosmetic composition with excellent whitening effect To provide.

In addition, the present invention contains one or more extracts selected from the group consisting of dandelion, Astragalus, stone, Agaricus, Changchun Hwa and stone, as an active ingredient, provides a cosmetic composition excellent in moisturizing effect.

In addition, the present invention contains one or more extracts selected from the group consisting of gourd green leaf, green tea seeds, Astragalus, dandelion, agaricus, dodol, stone and camellia as an active ingredient, provides a cosmetic composition excellent in anti-atopic effect.

In addition, the present invention contains one or more extracts selected from the group consisting of dandelion, Astragalus, Agaricus, green tea seeds, Cordyceps sinensis and Camellia skin as an active ingredient, provides a cosmetic composition excellent in the sunscreen effect.

Hereinafter, the present invention will be described in more detail.

The buckthorn is buckthorn grapes and deciduous vines. The stems are long and thick, dark brown, and the other vines are wrapped around the vines. Leaves face this tendril, pentagonal, 10-30cm in diameter, deep heart-shaped, with dense red-brown curly hairs underneath. Large conical inflorescence faces the leaves in June, and there is often one tendril at the bottom of the inflorescence. Flowers are small, yellow-green, calyxes are wheel-shaped, petals are joined together, the lower part is split, and when the flowers fall, they are separated from the flower sill. Axillary ball-shaped, about 1cm in diameter, ripens in black. It is sour and edible. It grows in Korea (Ulleungdo) and Japan. Among the components of the bee, anti-cancer ingredients include resveratrol, a tetramer of four molecules of polyphenol, catechin, and resveratol, such as hopiphenol, heininol, iso-pipiphenol, citcin, and bitifuran. The content of these ingredients may vary depending on the variety or region, but catechin is about 50 mg / kg, polyphenol is about 150 µg / ml (juice extract), and resveraton is about 60 µg / g (waste. More than doubled), and contains a large amount of hopiphenol, heinol, iso-hopiphenol, cyticin, bitisifuran and the like (root).

Golden silver scientific name Scutellaria Perennial grass with baicalensis , Lamiaceae, grows in grass of mountain area, height 20 ~ 60cm. Several generations come out, grow up in abandonment, have hairs, branches are split, leaves are facing each other in the shape of basso, and the edges are flat. Flowers bloom in July-August, turn purple, and run away from one side with gunshot inflorescences. Corolla curled at the bottom, standing straight, tubular, 1.5-2.5cm long, lip-shaped. Calyx is bell shaped. Two of the four surgeries are long, one pistil, and the ovary is deeply divided into four. Fruits are fruiting in September, rounded in calyx. The cone is conical and the flesh is yellow. In oriental medicine, roots are used as antipyretic, diuretic, branch, edam and anti-inflammatory agents, and they are grown as medicinal plants and distributed in Korea, China, Mongolia and eastern Siberia.

Green tea is a favorite food containing unique fragrances such as caffeine, theanine, and tannin and a large amount of vitamins, and is also widely used as a health drink to help improve health. In addition, it is a food containing a large amount of flavonoids, which contains purine base, catechins, and various other ingredients. Therefore, it suppresses cancer cell proliferation, lowers blood pressure, lowers cholesterol, inhibits platelet aggregation, and blood sugar. There are many health benefits such as synergistic inhibitory effect, fatty liver inhibitory effect, antibacterial effect, intestinal useful bacterial growth promotion effect, neovascularization inhibitory effect and whitening effect, and green tea is added to foods to take advantage of the various effects of green tea. Many studies are being conducted to derive the unique taste or aroma of green tea.

Rice bran is a pulverized mixture of skin, seedling and whistle layer from the process of turning from brown rice to white rice. Thus, rice bran is a byproduct of polished rice, but it is quite good in terms of nutrition. Rice bran contains vitamins A and B1, B6, iron, phosphorus and minerals. The standard chemical composition of rice bran is 13.5% moisture, 18.3% fat, 38.3% sugar, 7.8% fiber, and 8.9% ash. Vitamin B1 contains 2.5mg of 100g, and vitamin E is high. Rice bran contains many beneficial ingredients for the human body, and especially contains ingredients such as Peruvian acid, gamma-orolinol, and inositol. These ingredients are already used in various medicines in the cosmetics and pharmaceutical industry, and have a reputation for having a very high medicinal effect. Peruurasan is a bioactive substance that is rich in rice bran. The effects of inhibiting the damage of ultraviolet rays known as the cause of skin cancer and the inhibitory effect of melanin production are recognized. Gamma-orinol is a nutrient unique to rice bran, has rejuvenation of the skin, and climacteric dysfunction and autonomic ataxia (various symptoms caused by disorders of the autonomic nerve that control internal organs or hormones regardless of will) It is used as an effective ingredient for the improvement of.

Park Ju-Gi is a vine grass with several oysters belonging to the genus Gam-Gi-O-Gi. The leaves are opposite each other, long egg flower heart-shaped, and the back is white green. In July-August, peduncles extend higher than the leaves and light purple flowers bloom. The flower bill is deeply divided into 5 pieces with dense hairs inside the cracked pieces. The leaves are opposite, long oval heart-shaped, and the back is white green. In July-August, peduncles extend higher than the leaves and light purple flowers bloom. The flower bill is deeply divided into 5 pieces with dense hairs inside the cracked piece. Fruits are broad, lanceolate, large, with projections on the surface, with long white hairs on the seeds. Seeds and leaves are dried and medicated. Seed hair has been used as a substitute for cotton. Most of the genus is a panicle, and the petals are shorter than the flower stamens and have long horn-shaped protrusions on the pistil. Distributed from temperate to subtropical in East Asia. White latex contains toxic components and is a mild sterling silver herb. Leaves and fruits are medicinal for tonic, tonic and detoxification. Seed hair is used to make stamp rice and needle wrap instead of cotton. It is distributed in Korea, Japan, and China.

Dandelion is the herbal name of Pogongyoung (浦 公 英, Taraxam). coreanum , Compositae ), a perennial herb of the Asteraceae. Commonly called dandelion (dandelion), the entire plant, such as roots, leaves, flowers, stalks are used for medicinal purposes. The scientific name Taraxacum is known to have effects on the liver, gallbladder, and kidney as shown by the compound words of taraxis (anxiety) and aceomi (treatment). In Korea, it is divided into T. hallaisanense , T. ohwianum , T. coreanum , T. officinale , and short domestic species . Indigenous dandelion in Korea takes several years to grow after flowering and blooms in spring, and it is difficult to use because it is not self-fertilizing. Dandelion that we see a lot around us is a naturalized plant, many of which are T. officinale and have strong vitality and breeding ability, so it can be collected and cultivated all year round, and the roots are straight, thick, and 10 to 15 days old. It can be re-harvested, making it a very economical plant and especially effective for soaking kimchi. In addition, there is no limit to its use as it is recognized as GRAS (generally recognized as safe) grade 10 in the US. Its main ingredients are rich in vitamins and minerals, low in fat and calories, and are suitable for well-being foods.It is rich in high-flavored taraxin, inulin, and carotenoid, taraxatin ( taraxathin, taraxerol, a triterpene, taraxasterol, β-sitisterol, caffeic acid, taraxacine and other vitamins A and vitamin It is rich in C, tocopherol, Ca, Fe and K. The leaves have a diuretic that does not cause hypokalemia, and the high-flavored ingredients stimulate the digestive tract to help digestion, improve the liver function of taurine, and promote bile secretion to promote digestion of fat. In addition, it is used for hepatitis in oriental medicine, and in addition to detoxification, diuresis, and lactation, it also lowers heat, releases wool, and reduces inflammation. Viii) used. In Europe, the leaves are used as salads and the flowers are used to soak alcohol.

Dandelion's physiological activities include anti-oxidative activity, hydroxyl radical scavenging activity, antibacterial activity against food poisoning bacteria, antibacterial activity against inflammatory staphylococci and skin fungi. Kimchi fermented strains have been reported to have no effect. In addition, hot water extracts are known to have excellent antitumor effects, and have strong anticancer activity against sarcoma 180 (sarcoma 180) solid cancer. In addition, it is known to have an effect of improving lipid metabolism and anti-inflammatory effects in the body.

Cordyceps sinensis is a type of mushroom that parasitizes various insects in winter, but when the temperature and humidity increase in summer, it generates fruiting bodies or forms spores on the insects. The species of Cordyceps sinensis which are distributed and presented in the "Food Raw Material Classification Table" in the Korean Food Code include the Snowflake Cordyceps and Militaris Cordyceps. The useful components of Cordyceps sinensis have been reported as cordycepin, cordycepic acid, amino acids, polysaccharides, vitamins, etc., and antibacterial, anti-cancer, immune function enhancement, drug detoxification function, tumor growth Inhibitory and immunomodulatory functions are known.

The cosmetic composition for skin whitening of the present invention contains at least 0.01 to 10% by weight of the cosmetic composition with one or more extracts selected from the group consisting of seeds, golden, green tea seeds, rice bran, gourd green leaf, gourd green root and gourd green fruit. do.

In addition, the cosmetic composition for moisturizing the skin of the present invention contains one or more extracts selected from the group consisting of dandelion, Astragalus, stone, agaricus, Changchunhwa and Dool, based on the total weight of the cosmetic composition 0.01 to 10% by weight.

In addition, the cosmetic composition for anti-atopic dermatitis of the present invention is 0.01 to 10% by weight of one or more cold water selected from the group consisting of gourd green leaf, green tea seed, Astragalus, dandelion, agaricus, dodol, stone and camellia skin It is contained in%.

In addition, the sunscreen cosmetic composition of the present invention contains one or more extracts selected from the group consisting of dandelion, Astragalus, Agaricus, green tea seeds, Cordyceps sinensis and Camellia peel in 0.01 to 10% by weight relative to the total weight of the cosmetic composition.

Hereinafter, the present invention will be described in more detail with reference to test examples, but the scope of the present invention is not limited only to these examples.

( Reference Example ) Preparation of Extract of Natural Product

Each natural product is extracted with 300ml of 1500ml of ethanol (or water), refluxed for 4-6 hours without heating or heating, concentrated with an evaporator, and freeze-dried. To make a cream formulation.

( Test Example 1) investigation of natural products having a whitening effect

Tyrosinase inhibitory activity was measured using various natural products.

1 ml of 1.66 mM L-tyrosine solution, 1 ml of sample solution, and 1 ml of 30 mM sodium phosphate were added thereto, and then heated in a 37 ° C. constant temperature water bath for 10 minutes, and 0.01 ml of tyrosine in a 37 ° C. mixed solution. After mixing and adding the aze, the reaction was carried out for exactly 10 minutes in a 37 ° C. constant temperature water bath, taken out, immediately put in ice to stop the reaction, and the absorbance was measured at 475 nm. A sample containing 1 ml of distilled water, instead of 1 ml of sample solution, A was added to the sample solution and tyrosinase was added to B, and 0.01 ml of distilled water instead of tyrosinase was calculated as C. The value was obtained and the result is shown in FIG.

Referring to Figure 1, the seedlings, golden, green tea seeds, water extract of rice bran, ethanol extract of rice bran, gourd green leaf, gourd green leaf and gourd green fruit showed a very good effect on the whitening effect.

(Test Example 2) Measurement of natural products whitening

Distilled Water (DDW), Cosmetic Base Agent (Control), Dandelion Extract (DAD), Astragalus Extract (HWG), Mercury Seed Extract (WGS), Agaricus Extract (AGA), Rice Bran Ethanol Extract (SSGE), Rice Bran Ethanol Heated Extract (SSGEH) ), Rice Bran Water Extract (SSGW), Green Tea Extract (GT), Green Tea Seed Extract (GSE), Golden Extract (HGG), Dol-Eu (CHIL), Seok-I (SUK), Green Leaf, Green Leaf Extract, The whitening effect of the product was measured. After removing hair on the side of the experimental rat (Sprague-Dawley), the natural product was applied to the marking site, and the formulation of the natural product used was as follows.

Component (A) of Table 1 is mixed while warming to 80 ℃, component (B) is mixed with the extract of the natural product while heating to 70 ~ 75 ℃. If the extract of the natural product to be added is fat-soluble, it is added to component (A), and if water-soluble, it is added to component (B) to dissolve, then the two components are combined and mixed, cooled to 30 ° C, and stored at room temperature. Experiment. Photographs were taken 24 hours after application to the marking site, and the results are shown in FIGS.

Referring to Figures 2 to 4, the fruit seed extract, golden extract, green tea seed extract, rice bran water extract, rice bran ethanol extract, green leaves, gourd green leaf and gourd green fruit showed a very good effect on the whitening effect.

Animal experiments using two good effects in the above experiments are as follows. Animal experiments were conducted using green tea seed extract and rice bran water extract, rice bran water extract and gourd green leaf extract, green tea seed extract and gourd green leaf extract, and the results are shown in FIG. 5.

Referring to Figure 5, even if the two kinds of natural products can be seen that the whitening effect is remarkable.

Through the above test, the fruit seed extract, golden extract, green tea seed extract, rice bran water extract, rice bran ethanol extract, gourd green leaf extract, gourd green leaf extract, gourd green fruit extract, etc. are excellent in whitening effect. It was also confirmed that the effect was maintained.

(Test Example 3) The moisturizing effect of the measured natural products

1 ml of agar made with 1.5% agar on a plate, put the same amount, weighed, coated 3 times or more with gelatin, and then 1 ml of a specific cosmetic product containing natural products The natural products used in the experiment were Dandelion (DAD), Cha (CJJ), Green Tea (GT), Astragalus (HWG), Seok (SUK), Green Tea Seed (GSE), Agaricus (AGA), and Roe Deer. Fungus mushrooms (NRM), Changchunhua (JCW), Cordyceps sinensis (DCHC) and Dol extraneous (CHIL) extracts. After 18 hours at 37 ℃ after the coating was weighed and the moisturizing effect was measured by the reduced ratio, the results are shown in FIG.

Referring to Figure 6, dandelion (DAD), Astragalus (HWG), Suk (SUK), Agaricus (AGA), Changchunhwa (JCW) and Dol extraordinary (CHIL) and the like have a high effect of maintaining the moisturizing.

(Test Example 4) Measurement of atopic wherein effects of natural products

One of the symptoms of atopic dermatitis was itching, and it was measured whether the natural product had an effect on atopy by inducing itching and scraping.

Compound 48/80, an itch-inducing substance, is applied to the back area of the chest behind the neck of the Sprague-Dawley neck, and 0.5% of compound 48/80 is applied to the skin. Scraping was performed. After 24 hours, a mixture of Compound 48/80 and the sample was applied 1: 1 and compared to the number of scratches for 1 hour. The natural products used in the experiments were Astragalus, Green Tea Seed, Agaricus, Dol-E, Park Jujube Leaf, and Maroon Seed, green tea, dandelion, stone and camellia extract. The number of scratches after applying Compound 48/80 was 100, and the number of scratches after mixing and mixing the sample with Compound 48/80 was shown in FIG. 7.

Referring to Figure 7 as a natural product that suppresses atopy, green leaves, green tea seeds, Astragalus, dandelion, agaricus, stone, stone, camellia and the like showed a good effect.

(Test Example 5) after UV exposure of the natural product of the measured upper skin recovered effect

The mouse was exposed to hairless nude mice with 280-320nm UVB twice every two hours, two hours apart, and the skin was rough and flaky, and the natural products were applied. Is an extract of Dandelion, Astragalus, Agaricus, Green Tea, Cordyceps Sinensis, Sukki and Green Tea Seeds. After application, the state of the skin was photographed after 24 hours, and the results are shown in FIGS. 8 and 9.

8 and 9, the treated samples all played an important role in recovering the skin after UV treatment. All of the natural products used were found to restore skin to its original condition. Dandelion (DAD), Astragalus (HWG), Agaricus (AGA), Green Tea Seeds (GSE), Cordyceps Sinensis (DCHC) and Camellia Peel (KAP) show good effects.

Chemistry by providing a cosmetic composition containing natural products such as wild seed extract, golden extract, green tea seed extract, rice bran extract, gourd green extract, dandelion, yellow rice, stone, agaricus, chunchunhua, dol-eup, camellia rind and cordyceps as active ingredients Environment-friendly and low-toxicity than the use of synthetic ingredients, but also improve the skin condition can provide an excellent cosmetic composition.

Claims (9)

A cosmetic composition for skin whitening containing at least one extract selected from the group consisting of maroon seed, golden, green tea seed, rice bran, gourd green leaf, gourd green root and gourd green fruit as an active ingredient. The cosmetic composition according to claim 1, wherein the extract of rice bran contains water extract or ethanol extract and contains extracts of natural products. The cosmetic composition according to claim 1, wherein the active ingredient is contained in an amount of 0.01 to 10% by weight based on the total weight of the cosmetic composition. Skin moisturizing cosmetic composition containing as an active ingredient at least one extract selected from the group consisting of dandelion, Astragalus, Seokyi, Agaricus, Changchun Hwa and Dool et al. The cosmetic composition according to claim 4, wherein the active ingredient is contained in an amount of 0.01 to 10 wt% based on the total weight of the cosmetic composition. Anti-atopic cosmetic composition containing as an active ingredient at least one extract selected from the group consisting of gourd leaf, green tea seed, Astragalus, dandelion, agaricus, dole, stone, and camellia skin. The cosmetic composition according to claim 6, wherein the active ingredient is contained in an amount of 0.01 to 10% by weight based on the total weight of the cosmetic composition. Dandelion, Astragalus, Agaricus, green tea seed, Cordyceps sinensis and Camellia peel, sunscreen cosmetic composition containing as an active ingredient one or more extracts. The cosmetic composition according to claim 8, wherein the active ingredient is contained in an amount of 0.01 to 10% by weight based on the total weight of the cosmetic composition.

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