CN106214576A - A kind of whitening and speckle dispelling skin care item and preparation method and application - Google Patents
A kind of whitening and speckle dispelling skin care item and preparation method and application Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/73—Polysaccharides
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention belongs to skin care field, be specifically related to a kind of whitening and speckle dispelling skin care item and preparation method and application.Described whitening and speckle dispelling skin care item comprise the components such as Flos Lonicerae extract, Herb Gynostemmae Pentaphylli extract, Flos Inulae extract, MEIGUI CHUNLU, Peppermint essential oil, vitamin E, Oligomeric Proanthocyanidins, hyaluronate sodium and Butyrospermum parkii fruit fat, wherein, Flos Lonicerae extract, Herb Gynostemmae Pentaphylli extract, Flos Inulae extract etc. can reduce melanin and generate and have significant inhibitory action to tryrosinase, has whitening effect and the freckle effect of excellence.The whitening and speckle dispelling skin care item gentleness that the present invention provides does not stimulates, and is applicable to sensitive skin crowd, has good application prospect.
Description
Technical field
The invention belongs to skin care field, be specifically related to a kind of whitening and speckle dispelling skin care item and preparation method and application.
Background technology
Melanin is present in a kind of protein of everyone skin base layer, and ultraviolet irradiation can make melanin produce
Change, generates a kind of material protecting skin, moving layer by layer via cellular metabolism again, has arrived skin epidermal area, thus formed
The skin problem such as the mottle seen, the colour of skin are irregular, dark yellow.Female face pigmentation, tarnish, dark yellow etc. be young and middle-aged
The skin of face problem that women especially this age working woman is most commonly seen, affects emotion and the life of young and middle-aged women.
Traditional skin-lightening cosmetic, often uses chemical substance, such as hydrogen peroxide, ammoniated mercury and various phenols
Derivant, these compounds can make melanin tissue disintegrate rapidly, reach effect of quick whitening.But because skin is corroded by it
Property, the factor such as cytotoxicity and anaphylaxis, there is great danger, the most disabled in the hygienic practices of many countries.Mesh
The skin-lightening cosmetic of front requirement should comply with two standards: one is to have higher suppression ratio to tyrosinase activity, can significantly subtract
Few melanic generation；Two is to have higher safety, nontoxic non-stimulated to human body skin.Folium Vaccinii vitis-idaeae is general, vitamin C and derivative
Thing and kojic acid are the whitening compositions relatively often used in the most domestic and international skin-lightening cosmetic.
China's skin-lightening cosmetic has long history, and Nails always advocates the whitening effect of " skin such as snow, solidifying such as fat "
Really, but China is owing to being limited by Sci-Tech Level in modern age, at biology, the research of whitening agent is the most still located starting in theory
There are bigger gap in stage, relatively Japan and Korea S..In recent years, due to developing rapidly of national economy, people have had and have substantially carried quality of life
Height, the demand of whitening type cosmetics is doubled and redoubled by the public.Latter stage in 20th century, Dermatology, pharmacology, physiology, biology etc.
Having started to penetrate in cosmetic science, high security also has the cosmetics of certain physiological function the most progressively by consumers in general
Accept." green ", is the theme of 21 century cosmetics, and natural active cosmetic complies with the trend and people gone back to nature
Consumer psychology.Along with China joined WTO, the competition of production domesticization cosmetic and external famous brand will aggravate, and natural active cosmetic is special
Be not Chinese herbal medicine cosmetic will be the magic weapons won victory of China's cosmetics.The development of modern science and technology, solving natural active matter should
Series of problems, provide technology for the development of natural active cosmetic and ensure.In terms of sales volume and per capita consuming level,
China's natural cosmetics has the biggest development space.The potentiality it can be said that natural active cosmetic tool grows a lot, will become
The main flow of China's cosmetics development.
Summary of the invention
In order to overcome the deficiencies in the prior art and shortcoming, the primary and foremost purpose of the present invention is to provide a kind of whitening and speckle dispelling skin protection
Product.
Another object of the present invention is to provide the preparation method of above-mentioned a kind of whitening and speckle dispelling skin care item.
It is still another object of the present invention to provide the application of above-mentioned a kind of whitening and speckle dispelling skin care item.
The purpose of the present invention is achieved through the following technical solutions:
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
Described whitening and speckle dispelling skin care item, preferably comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item, comprises the steps of:
(1) by caprylic/capric triglyceride, Butyrospermum parkii fruit fat, cetearyl alcohol, glyceryl stearate and methyl
Sesquistearate mixes, and at 55～70 DEG C, heated and stirred mixing, obtains product 1；
(2) hyaluronate sodium, glycerol, butanediol, xanthan gum and water are mixed, heated and stirred mixing at 55～70 DEG C,
Obtain product 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum is equal
Matter emulsifying, obtains product 3；
(4), after prepared for step (3) product being cooled to 30～40 DEG C, mix all with remaining component of whitening and speckle dispelling skin care item
Even, obtain whitening and speckle dispelling skin care item；
Heated and stirred described in step (1) is preferably carried out in oil phase pot；
The condition of the heated and stirred described in step (1) is preferably heated and stirred 30～40min at 55～70 DEG C；
The condition of the heated and stirred described in step (1) more preferably heated and stirred 35min at 60 DEG C；
Heated and stirred described in step (2) is preferably carried out in aqueous phase pot；
The condition of the heated and stirred described in step (2) is preferably heated and stirred 20～30min at 55～70 DEG C；
The condition of the heated and stirred described in step (2) more preferably heated and stirred 25min at 60 DEG C；
The time of the vacuum emulsifying described in step (3) is preferably 5～20min；
The time more preferably 10min of the vacuum emulsifying described in step (3)；
The application in skin care field of the described whitening and speckle dispelling skin care item；
The principle of the present invention:
Comprising multiple natural plant sun extract in the whitening and speckle dispelling skin care item that the present invention provides, wherein, Flos Lonicerae carries
Take thing, in whole ultraviolet spectra district, there is good sun-proof performance, and Flos Lonicerae extract can have good antiseptic effect；
Herb Gynostemmae Pentaphylli extract contains gypenoside, aminoacid, protein, fat, flavonoid, saccharide, inorganic elements, cellulose and dimension
The Multiple components such as raw element, gypenoside can significantly reduce and suppress the formation of lipid peroxidation, and strengthens human body and epiderm skin
Cell SOD vigor and the ability of scavenging capacity oxygen-derived free radicals, improve the metabolism of body, protection Skin Cell from damage, and then
Prevent skin aging, extend cell survival, accelerate skin epidermal cells and update, ultraviolet and daylight etc. can be resisted to skin
Effect, prevents skin tanning, alleviates the chloasma that even disappears；Flos Inulae extract can alleviate pigmentation, alleviates dermatitis
Disease, reduces cutaneous sensibility, and MEIGUI CHUNLU is of value to people rich in multivitamin, glucose, fructose, citric acid, malic acid etc.
The nutrient substance that body is healthy, also rich in triterpenoid compound (triterpenoid compound has good defying age function), has and prolongs
Slow skin aging function, can effectively remove wrinkle；Butyrospermum parkii fruit fat is as skin conditioning agent and thickening agent: first, it is permissible
Assist in keeping moisture, form protective barrier at skin surface, reduce water loss；This material contains the fat of non-saponified, this meaning
Taste, and unlike other fatty oils, if with the presence of other highly basic, it will not form soap base, thus keeps its
Moisture-retaining capacity.Secondly, it can also reduce the degree of roughness of skin and be dried, and it can help epidermis cell structure to keep
Whole, effectively to antibacterium, beneficially skin healing, prevent skin irritation and make skin regeneration；3rd, this material can also disappear
Inflammation, help to releive skin pruritus, stimulation or skin burn.The most always, it has the natural energy absorbing solar ultraviolet
Power, protects the skin from injury, also has oxidation resistance properties.Flos Lonicerae extract, Herb Gynostemmae Pentaphylli extract, Flos Inulae extract,
MEIGUI CHUNLU and the compounding propagation to tryrosinase and melanocyte of Butyrospermum parkii fruit fat have significant inhibitory action, have
Excellent whitening effect.Vitamin E uses as antioxidant, has slow down aging, reduces wrinkle, effect of speckle dispelling and can promote
Entering the absorption of skin care item, Oligomeric Proanthocyanidins is as the protective agent of vitamin E, and Oligomeric Proanthocyanidins skin is non-stimulated, to skin
Skin has anti-oxidation protection effect, can improve the skin protection whitening and speckle dispelling effect of these skin care item；Hyaluronate sodium, is the structure of human body skin
One of become, be the widest a kind of acid glutinous sugar of people's distribution in vivo, be present in the substrate of connective tissue, there is good moisturizing and make
With；Glycerol, caprylic/capric triglyceride, butanediol, as wetting agent and emollient, can have the strongest with adsorbed water molecule
Moisture-keeping function, wherein butanediol is as little molecule wetting agent, and it is the least to grab water ratio, is possible to prevent waving of other volatile components
Send out, have certain bacteriostasis simultaneously.
The present invention has such advantages as relative to prior art and effect:
(1) the whitening and speckle dispelling skin care item that the present invention provides comprise multiple natural plant sun extract, wherein, Flos Lonicerae
Extract, Herb Gynostemmae Pentaphylli extract, Flos Inulae extract etc. can reduce melanin and generate and have tryrosinase and significantly press down
Make use, there is the whitening effect of excellence.
(2) Flos Lonicerae extract comprised in the whitening and speckle dispelling skin care item that the present invention provides can have good anticorrosion effect
Really, it is not necessary to add extra chemical preservative, natural, safety, green.
(3) Herb Gynostemmae Pentaphylli extract and the Flos Inulae extract comprised in the whitening and speckle dispelling skin care item that the present invention provides can subtract
Light pigmentation, has good freckle effect.
(4) the whitening and speckle dispelling skin care item milder that the present invention provides, is applicable to sensitive skin crowd.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Flos Lonicerae extract (chlorogenic acid content >=15%) in embodiment, (Herb Gynostemmae Pentaphylli total glycosides contains Herb Gynostemmae Pentaphylli extract
Amount >=80%) purchased from Shaanxi Zhong Xin Bioisystech Co., Ltd；Flos Inulae extract (product specification: 10:1) is purchased from Xi'an match Austria
Bioisystech Co., Ltd；Butyrospermum parkii fruit fat is purchased from Bai Chuan bio tech ltd, Xi'an.
Embodiment 1
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item, comprises the steps of:
(1) by caprylic/capric triglyceride, Butyrospermum parkii fruit fat, cetearyl alcohol, glyceryl stearate and methyl
Sesquistearate mixes in oil phase pot, 60 DEG C of heated and stirred 35min, obtains product 1；
(2) hyaluronate sodium, glycerol, butanediol, xanthan gum and water are mixed in aqueous phase pot, 60 DEG C of heated and stirred
25min, obtains product 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum is equal
Matter emulsifying 10min, obtains product 3；
(4), after prepared for step (3) product being cooled to 30 DEG C, mix homogeneously with remaining component of whitening and speckle dispelling skin care item,
Obtain whitening and speckle dispelling skin care item.
Embodiment 2
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item, comprises the steps of:
(1) by caprylic/capric triglyceride, Butyrospermum parkii fruit fat, cetearyl alcohol, glyceryl stearate and methyl
Sesquistearate mixes in oil phase pot, 50 DEG C of heated and stirred 40min, obtains product 1；
(2) hyaluronate sodium, glycerol, butanediol, xanthan gum and water are mixed in aqueous phase pot, 55 DEG C of heated and stirred
30min, obtains product 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum is equal
Matter emulsifying 5min, obtains product 3；
(4), after prepared for step (3) product being cooled to 40 DEG C, mix homogeneously with remaining component of whitening and speckle dispelling skin care item,
Obtain whitening and speckle dispelling skin care item.
Embodiment 3
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item, comprises the steps of:
(1) by caprylic/capric triglyceride, Butyrospermum parkii fruit fat, cetearyl alcohol, glyceryl stearate and methyl
Sesquistearate mixes in oil phase pot, 70 DEG C of heated and stirred 30min, obtains product 1；
(2) hyaluronate sodium, glycerol, butanediol, xanthan gum and water are mixed in aqueous phase pot, 70 DEG C of heated and stirred
20min, obtains product 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum is equal
Matter emulsifying 20min, obtains product 3；
(4), after prepared for step (3) product being cooled to 35 DEG C, mix homogeneously with remaining component of whitening and speckle dispelling skin care item,
Obtain whitening and speckle dispelling skin care item.
Comparative example 1 (without Flos Lonicerae extract)
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item is with embodiment 1.
Comparative example 2 (without Herb Gynostemmae Pentaphylli extract)
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item is with embodiment 1.
Comparative example 3 (without Flos Inulae extract)
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item is with embodiment 1.
Comparative example 4 (without Butyrospermum parkii fruit fat)
A kind of whitening and speckle dispelling skin care item, comprise following component the most by mass percentage:
The preparation method of described whitening and speckle dispelling skin care item is with embodiment 1.
Effect example
One, Cavia porcellus whitening effect investigates experiment
Taking each 10 of black Cavia porcellus male and female, body weight is 250～350g, divides 7 groups, often group 4.Administration group is shaved in both sides, back
Hair become 3cm × 3cm size go to hair-fields, with swab stick take experiment reagent (1% whitening and speckle dispelling skin care item) arranged on left and right sides skin be coated with
Smear uniformly, every day 2 times.Naive animals to lose hair or feathers in both sides equally, and ensures the phase similar shape of other experiment conditions and experimental group
Shine in pairs.In Cavia porcellus feeding process, to strictly control indoor temperature and be maintained at about 25 DEG C, relative humidity be maintained at 50%～
Between 60%, every Cavia porcellus is taken food feedstuff 10～15g, Radix Dauci Sativae or vegetable 10～15g every time, the endless supply of water.Through 28
After it, take guinea pig skin living tissue, fix with 10% formalin, paraffin embedding, cut into slices, observe.Use Image-
ProPlus6.0 software, to analysis of being taken a picture, uses optical density/section area and optical density/melanocyte area to characterize melanocyte
Content.30 photos of each slide random shooting carry out processing statistical analysis.Result such as following table:
Table 1 different group contrast of melanocyte value after ferrous sulfate absorption process dyes
As it can be seen from table 1 embodiment 1～3 is either from optical density/section area or optical density/melanocyte face
Amass and be below comparative example 1～4, Flos Lonicerae extract, Herb Gynostemmae Pentaphylli extract, Flos Inulae extract and Butyrospermum parkii fruit are described
Fat is compounding can significantly improve whitening effect.
Two, normal individual trial experiment
The whitening and speckle dispelling skin care item prepared are carried out clinic trial observation.
The object of observation: age 20～45 years old middle-aged women.Choosing face has chloasma in various degree, butterfly spot, senile plaque
Female middle-aged 100 example Deng pigment.
Observational technique: before sleep every night after cleaning skin, coat above-mentioned whitening and speckle dispelling skin care item.Use 28 days continuously
It it is a course for the treatment of.
Criterion of therapeutical effect: (1) is effective: melanin disappears and reaches more than 90%, skin has the most moist smooth feeling；(2) effective:
Melanin disappears more than 50%, and skin is relatively moistened smooth；(3) invalid: unchanged before and after treatment.Result is as shown in table 2:
Table 2 normal individual trial experiment effective percentage result
The above results shows: whitening and speckle dispelling skin care item Flos Lonicerae extract that the present invention prepares, Herb Gynostemmae Pentaphylli extract, gold small cup
Flower extract and Butyrospermum parkii fruit fat is compounding is possible not only to significantly improve whitening effect, and have and well moisten moisturizing, light
Change speckle dispelling and effect of gloss exquisiteness.
Above-described embodiment is the present invention preferably embodiment, but embodiments of the present invention are not by above-described embodiment
Limit, the change made under other any spirit without departing from the present invention and principle, modify, substitute, combine, simplify,
All should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (10)
1. whitening and speckle dispelling skin care item, it is characterised in that comprise following component the most by mass percentage:
Whitening and speckle dispelling skin care item the most according to claim 1, it is characterised in that comprise following group by mass percentage
Point:
3. the preparation method of the whitening and speckle dispelling skin care item described in claim 1 or 2, it is characterised in that comprise the steps of:
(1) by caprylic/capric triglyceride, Butyrospermum parkii fruit fat, cetearyl alcohol, glyceryl stearate and methyl sesquialter
Stearate mixes, and at 55～70 DEG C, heated and stirred mixing, obtains product 1；
(2) hyaluronate sodium, glycerol, butanediol, xanthan gum and water being mixed, at 55～70 DEG C, heated and stirred mixing, obtains
Product 2；
(3) under agitation, the product 2 that the product 1 step (1) prepared prepares with step (2) mixes, and vacuum homogenized milk
Change, obtain product 3；
(4), after prepared for step (3) product being cooled to 30～40 DEG C, mix homogeneously with remaining component of whitening and speckle dispelling skin care item,
Obtain whitening and speckle dispelling skin care item.
The preparation method of white spot-eliminating skin care product the most according to claim 3, it is characterised in that:
Heated and stirred described in step (1) is carried out in oil phase pot.
The preparation method of white spot-eliminating skin care product the most according to claim 3, it is characterised in that:
The condition of the heated and stirred described in step (1) is heated and stirred 30～40min at 55～70 DEG C.
The preparation method of white spot-eliminating skin care product the most according to claim 3, it is characterised in that:
Heated and stirred described in step (2) is carried out in aqueous phase pot.
The preparation method of white spot-eliminating skin care product the most according to claim 3, it is characterised in that:
The condition of the heated and stirred described in step (2) is heated and stirred 20～30min at 55～70 DEG C.
The preparation method of white spot-eliminating skin care product the most according to claim 3, it is characterised in that:
The time of the vacuum emulsifying described in step (3) is 5～20min.
The preparation method of white spot-eliminating skin care product the most according to claim 8, it is characterised in that:
The time of the vacuum emulsifying described in step (3) is 10min.
10. the application in skin care field of the whitening and speckle dispelling skin care item described in claim 1 or 2.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108309917A (en) * | 2018-05-03 | 2018-07-24 | 左雨萌 | Plant extract skin care product and preparation method thereof with effects of wrinkle resistance, whitening and freckle removal |
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| JPWO2019098352A1 (en) * | 2017-11-17 | 2021-01-14 | ロート製薬株式会社 | Cosmetological composition, screening method and cosmetological method |
| CN108309917A (en) * | 2018-05-03 | 2018-07-24 | 左雨萌 | Plant extract skin care product and preparation method thereof with effects of wrinkle resistance, whitening and freckle removal |
| CN116077385A (en) * | 2022-08-26 | 2023-05-09 | 陕西慧康生物科技有限责任公司 | Skin care composition containing Ruipage and application thereof |
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