KR101252560B1 - Cosmetic composition containing extracts of Impatiens balsamina L. for controlling anti-acne or anti-comedone - Google Patents

Abstract

The present invention relates to a cosmetic composition containing a natural product excellent in safety and effective in the prevention or treatment of acne. More specifically, the present invention relates to a cosmetic composition which is effective in the prevention or healing of acne by containing at least one selected from the group consisting of Balsam extract or Balsam extract among natural products as an active ingredient in the extract of Funglam, Silver and Licorice.

Balsam, mulberry, gilding, licorice, acne, cosmetic composition

Description

Cosmetic composition for improving acne containing balsam extracts {Cosmetic composition containing extracts of Impatiens balsamina L. for controlling anti-acne or anti-comedone}

The present invention relates to a cosmetic composition that is effective in the treatment or prevention of acne by containing natural products.

Acne is a chronic sebaceous inflammatory disease caused by clogged sebaceous hyperkeratosis in the pores, with 70-80% of patients focused on the age group of 11-25 years old. It can be said to be one of the skin features. The causes of acne can be largely explained by the increase in sebum secretion, stenosis caused by hyperkeratosis of hair follicles, the proliferation of acne bacteria, inflammatory reactions, and the like, depending on the degree of development of acne symptoms. It can also work.

If you look at the main factors,

First is the excessive secretion of sebum. Estrogen, a sex hormone that increases after puberty, excessively increases sebum secretion, producing sebum constantly, and secretes sebum on the skin surface from the sebaceous gland through anvilhead. In adult men, sebum secretion is constant due to testosterone activity secreted from the testis, but in women, acne worsens before and after menstruation because an increase in antibody hormone stimulates sebaceous glands and increases sebum secretion for a certain period after ovulation. It may become.

Second is keratinization of hair follicles. Anterior keratin hyperplasia tends to occur in the hair follicles of the hair follicles.As the thickened stratum corneum peels off the hair follicles, the hair follicles become blocked, which causes the scalp to form. Sebum is stagnated on the anvil to form microsurface. The result is an increase in acne bacillus, and its production stimulates the epithelial cells of the anvil, further enhancing keratinization.

Third is the growth of acne bacteria. Human blood normally contains many types of bacteria, called dermatophytes. Acne bacteria (Propionibacterium acnes) (hereinafter referred to as P. acnes) metabolize lipids in sebum to produce a number of fatty acids that are stimulating agents, and also recognized as antigens Inflammatory reactions occur because they stimulate the body's immune response. This causes papules and inflammatory acne lesions, and when deteriorated develops lesions such as cysts and pustules that destroy the hair follicle wall and damage tissues.

These three are the main factors that produce acne, but the enlargement of sebaceous glands, hyperkeratosis of the follicle pores, and the effects of bacteria are complicated to exacerbate acne, each of which makes acne alone. In addition, genetic factors such as the predisposition to acne, external factors such as the season, climate, food effects, fatigue and stress also related to acne. The cause of acne is still not clearly identified, but if the genetic and environmental factors are excluded, it has been confirmed in previous studies that the three important causes are directly involved in the development of acne.

There is a method of using oral or external preparations for the treatment of acne. Specifically, anti-sebum production methods using anti-male hormones, anti-inflammatory action of steroid hormones and nonsteroidal anti-inflammatory drugs, including lesochinol, sulfur, salicylic acid, benzoyl peroxide, retinoic acid or isotretinoin There is a method for inhibiting the activity of propionibacterium acne bacteria by antibiotics such as antimicrobial agents and exfoliants, tetracycline, erythromycin, and macrocycline. On the other hand, recently, a lot of treatment methods using azelaic acid have been used.

However, the methods described above have some results in acne treatment, but have some problems in terms of effectiveness, side effects, and usability. The use of hormonal agents has been reported side effects of hormonal abuse such as growth inhibition of the epidermis, and keratin peeling agents such as retinoic acid and benzoyl peroxide are known to have antibiotics, including tetracycline, which may cause skin irritation and contact dermatitis. The substance is known for bleeding and photosensitization of resistant bacteria. In particular, isotretinoin is known to have a teratogenic effect on the fetus.

Therefore, the necessity of developing a stable and excellent effect on the human body in acne skin is steadily emerging.

Therefore, the present inventors have conducted intensive studies to develop cosmetics that can prevent and cure acne, and as a result, antimicrobial effect and the antimicrobial effect on the composition further comprising extracts such as Funglam, Silver, Licorice, etc. It has been found that the effect of inhibiting lipid synthesis has an effect on the healing or prevention of acne to complete the present invention.

That is, an object of the present invention is to provide a cosmetic composition that is effective in the prevention or healing of acne, which contains Balsam extract or Balsam extract, which contains more Fung, Geum or Licorice extract.

In order to achieve the above object, the present invention is characterized by containing Balsam extract as an active ingredient.

In addition, the Balsam extract is characterized in that it further contains at least one extract selected from the group consisting of Sunglam, gold and silver licorice as an active ingredient.

Hereinafter, the present invention will be described in more detail.

General properties, applications and identification test methods for balsam, mulberry, gold and licorice used in the present invention are as follows.

Balsam is an annual plant of the family Balsam, whose scientific name is Impatiens balsamina L., and is planted for ornamental purposes at home. The height is about 60cm, the stem is round and fleshy, the leaves are basso, and the fusiform fruits are used as medicinal herbs. In summer, red flowers, white flowers, etc. bloom, which are used to water nails. It is native to India, Malay and southern China. Balsam is used to treat pain, bruises, swelling, especially white flower balsam is effective in low back pain, infertility, menstrual irregularities, lobster, harvest, blood, neuralgia, kidney stones, urethral stones, fish poisoning, constipation.

Sungram board is also known as ramgeun (板藍根), the Korean War of the cruciferous (Isatis tinctoria L.). In China, it is the same as Korea, but in Japan, it was not imported as a process herbal medicine. Sungrak has a function of lowering and detoxifying fever, which is used for fever, headache, sore throat and mumps, but pharmacological action is unknown. The shape is columnar, twisted and slightly curved, and the outer side is light brown. Root head is a little thick, leaves and stems and leaves attached, there are traces of vertical wrinkles, trees and side roots. The vagina is brittle, the cross section is white, and the neck is pale yellow.

Gold coins are also called Indongcho, and they contain ingredients such as tannins, alkaloids, isocitol, flavonoids, luteonine, saponins, and loriserine, which promote the release of sedative sodium chloride. It has been known that drinking gold and silver coins as a tea can clear blood, remove poisons from the body, strengthen the stomach, and facilitate the discharge of urine. It is also known that bathing gold and silver coins in bath water is effective in treating swelling, joint pain, and bruises. In addition, gold and silver has a sweet and cold energy to fever and detoxification, it is known to act to reduce inflammation and discharge boil pus. In addition, gold and silver coins have bactericidal, immune responsive, anti-inflammatory, anti-inflammatory and analgesic, diuretic, anticancer, antiviral, etc. Conjunctivitis, stomatitis, colitis, cystitis, appendicitis, gastric ulcer, low back pain, arthritis, hemorrhoids, cold, diarrhea, febrile disease, acid fever detoxification, acute gonorrhea, syphilis, diabetes, skin beauty, etc. are known to be effective.

The scientific name of licorice is Glycyrrhiza It is a glabra and is a medicinal plant. The roots are reddish brown deep into the ground, the stems are gathered, and grow straight about 1m. In addition, white hairs are dense and appear gray-white, and preemption is scattered. The leaves are shifted and oddly littered leaf. Small leaves 7 ~ 17 each, egg-shaped, pointed end. The leaves are 2 ~ 5cm long, l ~ 3cm butterfly, with white hairs and dots on both sides, and no sawtooth. Flowers bloom in July-August, 1.4-2.5cm long, purple, and hanged on the axilla as a total inflorescence. The pod is long and thin like a line and bent like a bow, and has 6-8 seeds of kidney type. The root is sweet, so use it as a sweetener or herbal medicine. Glycyrrhizin or genin, the main component, activates estrogen and has anti-inflammatory, detoxification and anti-allergic effects. In addition, fractions containing a large amount of flavonoids have anti-ulcer action and mycelial action.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the scope of the present invention is not necessarily limited to these examples.

 Reference Example 1 Preparation of Balsam Extract

When the summer flowers bloomed, the ground parts of the balsam were cut, and the stems, flowers, and fruits were dried in the sun. The dried stems, flowers, and pulp parts were each purified and finely crushed, and then cooled for 5 days in a 5-fold extraction solvent. The extract was filtered and concentrated to obtain extracts of stems, flowers, and fruits. At this time, ethanol was used as the extraction solvent.

Reference Example 2 Preparation of Soong-lam Extract

Soonglam 10 ~ 11Wil roots are dried like half the sun in the sun, and then the soil is removed and dried. The dried roots were finely crushed and chilled in a 5-fold extraction solvent for 2 days, and then the extract was filtered and concentrated to obtain an extract. At this time, ethanol was used as the extraction solvent.

REFERENCE EXAMPLE 3 Preparation of Gold Coin and Licorice Extract

Gold, silver and licorice extraction method is as follows. First, their roots, stems, leaves, and flowers were purified and powdered to extract about 1-10 times the amount of methanol, ethanol, propanol, butanol, purified water, glycerol, propylene glycol, 1-3- with respect to each dry weight. After cooling for 5-10 days using one or two or more mixed solvents selected from polyols such as butylene glycol, methyl acetate, ethyl acetate, benzene, hexane, diethyl ether, and dichloromethanol, the extract is filtered and concentrated. And a dry powder of each extract by a method such as lyophilization.

The antimicrobial and lipid production inhibitory effects of extracts of Balsam, Mullam, Geummi and Licorice obtained by the above method were measured as follows.

Test Example 1 Antibacterial Effect Measurement by Natural Product Sample

The antibacterial effect of representative triclosan as extracts of Balsam, Sungram, Geum and Licorice and chemical synthetic antimicrobial agents was examined.

<Bacteria>

Propionibacterium , acne bacterium acnes ATCC 6919 was used.

<Test method>

The antimicrobial activity against P. acnes was determined by liquid medium dilution method. After diluting each sample in 100 ppm intervals from 0 to 1000 ppm in 2 ml of liquid BHI medium, 20 μl of 10 ⁶ / ml of the bacterial solution was inoculated and incubated for 48 hours. The minimum concentration at which growth was inhibited based on turbidity was defined as the minimum growth inhibition concentration (MIC). The results obtained are shown in Table 1 below.

sample
Minimum Growth Inhibitory Concentration (PPM) P.acnes ATCC 6919 Balsam flower 1700 Balsam fruit 1000 Balsam Stem 400 Adoration 1200 Gold coins 1200 licorice 600

As shown in Table 1, it can be seen that the extracts of Balsam, Solam, Geum, Licorice have antibacterial activity against acne bacteria, and among them, the antibacterial activity of Balsam stems was particularly excellent.

Experimental Example 2 Lipogenesis Inhibition Test

The sebaceous glands are many hamster biopsy (biopsy) the ear tissue in order to assess the degree of lipid synthesis inhibition on sebaceous gland by the method for evaluating the consumption of the carbon element (uptake) Lipid synthesis inhibitors to quantify the extent to the extent necessary for lipid synthesis is C ¹⁴ Incubated for 6 hours in a labeled medium and the degree of inhibition was assessed by comparative quantitation of the control and the sample group using a radiometer. As a sample group, 0.01% of the sample solution was added to the medium using hamster right ear tissue, and 0.01% of physiological saline was added to the medium using the hamster left ear tissue as a control group. The results are shown in Table 2. Inhibition rate in Table 2 was calculated by the following formula 1, the value is the average value performed for five hamsters.

Inhibition rate (%) = sample group / control group × 100

sample % Inhibition Balsam flower 72 Balsam seeds 66 Balsam Stem 24 Adoration 52 licorice 18 Gold coins 64

As shown in Table 2, it can be seen that extracts of Balsam, Solam, Geum and Licorice have an inhibitory effect on lipid synthesis. Therefore, sebum is reduced by inhibiting lipid synthesis, thereby suppressing the occurrence of acne.

[Examples 1-11, Comparative Example 1]

In order to measure the effects on the acne skin and skin irritation of the composition for acne skin containing Balsam, Mullam, gilding and licorice, a skin lotion, which is one of the skin cosmetics for acne skin, was prepared.

Raw material Content (weight 100%) Disodium iodide 0.02 Betaine 2.0 Fiji Fiji-17.6 copolymer 3.0 glycerin 1.0 Butylene Glycol 2.0 Ethanol 7.0 Polyoxyethylene Hydrogenated Castor Oil 0.4 Polysorbate 20 0.15 Salicylic Acid 0.25 Methylparaben Suitable amount Combination fragrance Suitable amount Purified water To 100 Natural product extract
(One or more of Balsam, Solam, Gummi, Licorice) Kind content see Table 4

In the following Table 4, "○" mark indicates that the natural product marked "○" is additionally used in the composition of Table 3. In addition, the content of natural products used in each example is 0.2% balsam flower, 0.2% balsam seed, 0.2% balsam stem, 0.05% mulberry, 0.2% licorice, 0.2% gold and silver.

Natural products Example Comparative Example 1 One 2 3 4 5 6 7 8 9 10 11 Peach blossom ○ Balsam seeds ○ Balsam Stem ○ ○ ○ ○ ○ ○ ○ ○ Adoration ○ ○ ○ ○ ○ Gold coins ○ ○ ○ ○ ○ licorice ○ ○ ○ ○ ○

[Test Example 3] Primary skin irritation test

Human skin stimulation test was carried out with Examples 1 to 11 and Comparative Example 1 in order to determine whether the extract of Balsam, Sungram, Geum and Licorice is harmful to the human body when applied to cosmetics.

Human skin primary stimulation test was a human patch test (human patch test). That is, 30 healthy women aged 20-30 years old were tested according to CTFA guidelines (The Cosmetic, Toiletry and Fragrance Association. Inc. Washington, D.C., 20036, 1991). 20 μl of the test substance (10% in patch base) prepared in the Finn Chamber was added dropwise, washed with 70% ethanol, dried, and fixed on the back of the test site with a micropore tape. I was. After 24 hours, the fan chamber was removed and the skin change was read visually and the results are shown in Table 5. In Table 5, the average reactivity was calculated according to Equation 2 below, and after 24 hours of patch,-is no erythema or unusual phenomenon, ± is slightly redder than the surroundings, + is significantly redder than the surroundings, and ++ is reddened and swollen more than the surroundings. The criterion of the rating was less than 0.1 for class I (no stimulation range), less than 0.3 for class II (hard stimulation range), less than 0.5 for class III (medium stimulation range), and 0.55 or more for class IV (strong stimulation range). It was based on.

Average Responsiveness = [(±) Number * 1 + (+) Number * 2 + (++) Number * 3] / Number of Subjects

Test substance Judgment result Average reactivity
Judgment grade
- ± + ++ Example 1 27 3 - - 0.1 I Example 2 28 2 - - 0.07 I Example 3 27 2 One - 0.13 Ⅱ Example 4 27 2 One - 0.13 Ⅱ Example 5 26 2 2 - 0.2 Ⅱ Example 6 27 2 One - 0.13 Ⅱ Example 7 26 3 One - 0.17 Ⅱ Example 8 26 2 2 - 0.2 Ⅱ Example 9 27 3 - - 0.1 I Example 10 26 3 One - 0.17 Ⅱ Example 11 27 2 One - 0.13 Ⅱ Comparative Example 1 27 2 One - 0.13 Ⅱ

As shown in Table 5, Comparative Example 1, a cosmetic containing no natural product extract, showed a stimulus value in a safe range, but the stimulus was rather high. All the ingredients showed a stimulus below grade II in the test prescription, and the combinations of various ingredients were below the safety range of grade II (less than 0.3 stimulus level).

Test Example 4 Measurement of Improvement of Acne

20 women 19 to 26 years of age with acne were to use the lotion of Examples 1 to 11, and Comparative Example 1 using the same method of daily lotion for each 4 weeks, according to the opinion of the user to improve It was judged according to the evaluation criteria of. The test results are shown in Table 6.

<Evaluation Criteria>

+++: Very good improvement.

++: Significant improvement.

+: A slight improvement.

±: No improvement but no weakening

-: No improvement, rather weakened.

Test substance term 1 week 2 weeks 3 weeks 4 weeks Example 1 ± ± + + Example 2 ± + + + Example 3 ± + ++ ++ Example 4 ± + ++ ++ Example 5 ± + ++ ++ Example 6 ± + ++ ++ Example 7 + + ++ ++ Example 8 ± + ++ ++ Example 9 ± + ++ ++ Example 10 + ++ ++ +++ Example 11 ± + + + Comparative Example 1 ± ± ± ±

As can be seen in Table 6, it can be seen that the lotion containing extracts of balsam, mulberry, gold and silver licorice has an improvement effect on acne, among which all contain extracts of balsam stem, mulberry, gold and licorice. The lotion of Example 10 was found to have the best improvement on acne.

As described above, the cosmetics according to the present invention further contain one or more extracts selected from the group consisting of Balsam extract or Balsam extract, from the group consisting of Solam, Gold and Cocoa Licorice, which have antibacterial effects, lipid synthesis inhibition, etc. Or it can be seen that it is effective in prevention. Among them, cosmetics containing Balsam stem extract and Sunglam, gold and silver or licorice extract can be seen that the acne treatment and prevention effect is more excellent.

Claims (5)

Acne-improving cosmetic composition, characterized in that it contains the extract of Balsam, Sorak, Geum and Licorice as an active ingredient. delete The cosmetic composition for improving acne according to claim 1, wherein the balsam is a stem, a flower or a fruit. The cosmetic composition for improving acne according to claim 1, wherein the cosmetic composition inhibits Propionibacterium acnes , which is an acne bacterium. According to claim 1, wherein the cosmetic composition is a cosmetic composition for improving acne, characterized in that to inhibit Lipogenesis (Lipogenesis).