CN105147555A - Muslim plant skin care composition, Muslim plant cream as well as preparation methods of Muslim plant skin care composition and Muslim plant cream and application of Muslim plant skin care composition - Google Patents
Muslim plant skin care composition, Muslim plant cream as well as preparation methods of Muslim plant skin care composition and Muslim plant cream and application of Muslim plant skin care composition Download PDFInfo
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Abstract
The invention discloses a Muslim plant skin care composition, a Muslim plant cream as well as preparation methods of the Muslim plant skin care composition and the Muslim plant cream and an application of the Muslim plant skin care composition, belonging to the field of cosmetics. The Muslim skin care composition comprises the following raw materials in parts by weight: 30-60 parts of Inca inchi, 20-60 parts of garden balsam, 10-30 parts of olives and 10-30 parts of badam. The Muslim plant cream is prepared by mixing a plant extract obtained through extraction after compounding the active pharmaceutical ingredients with conventional auxiliary materials in the field of skin care products in proportion. The Muslim plant skin care composition and the Muslim plant cream have the functions of controlling oil, scavenging free radicals and removing redness and are safe and non-irritating to skins through verification by human patch tests. The Muslim plant skin care composition and the Muslim plant cream are disclosed aiming at Muslim people and have the beneficial effects that the raw materials are natural and are easy to gain; the preparation methods are simple and convenient; and the Muslim plant skin care composition and the Muslim plant cream are green and safe and have good application and market prospects.
Description
Technical field
The present invention relates to a kind of skin care compositions, be specifically related to a kind of the Islamic plant composition for skin care, Islamic plant cream frost and its preparation method and application with control oil, scavenging free radicals and Red blood streak dispelling effect, belong to cosmetic field.
Background technology
Latest data shows, and world population is to break through 7,000,000,000 high pointes, and wherein China is the populous nation that beats the world, and is secondly India; Whole Asia population is to reach 4,200,000,000.According to statistics, current Moslem's population more than 1,600,000,000, and expect the year two thousand thirty Moslem population will close to 2,000,000,000.Up to the present, Asia Moslem's population has reached more than 700,000,000 people, accounts for 62% of global Moslem's population.In the world, rank forefront in the country of ten at Moslem's population, Dou Shi Asian countries of the first four place country is Indonesia (200,000,000), Pakistan (1.8 hundred million), India (1.8 hundred million), Bangladesh (1.5 hundred million) respectively.
Moslem's cosmetics could must be accepted by vast " Moslem " people through Halal certification, and the guiding theory of product design is natural, environmental protection, health; Do not add animal oil, with extracts such as natural plants fruit, rhizomes for main active substances, the production technology and the production procedure that are equipped with advanced person obtain.At present, the superfine cosmetics sales shop of state's inside trade, does not almost accord with the cosmetics of " Moslem " crowd demand completely.Due to particularitys such as Moslem's cosmetic material source, certifications, to such an extent as to the available cosmetics of the Moslem people are few.
In the face of the particularity of numerous Moslem crowds and the consumer group, develop Islamic cosmetics targetedly and corresponding cosmetics consumption concept is provided, there is wide market prospect.
Summary of the invention
First object of the present invention is to provide a kind of Islamic plant composition for skin care, and said composition has effect of control oil, scavenging free radicals and Red blood streak dispelling;
Second object of the present invention is the preparation method providing a kind of described Islamic plant composition for skin care;
3rd object of the present invention is to provide a kind of Islamic plant cream frost, and this Islamic plant cream frost comprises the active component of above-mentioned Islamic plant composition for skin care;
4th object of the present invention is to provide a kind of method preparing described Islamic plant cream frost;
5th object of the present invention is to provide described Islamic plant composition for skin care to have the application in the cosmetics of control oil, scavenging free radicals and Red blood streak dispelling effect in preparation.
Above-mentioned purpose of the present invention is achieved by the following technical solution:
A kind of Islamic plant composition for skin care, is characterized in that, be made up of the crude drug of following weight portion: Inca inchi 30 ~ 60 parts, Flos Impatientis 20 ~ 60 parts, olea europaea fruit 10 ~ 30 parts, Amygdalus communis Lamarck 10 ~ 30 parts.
In the present invention, preferably, the weight portion of each crude drug is: the weight portion of each crude drug is: Inca inchi 40 ~ 60 parts, Flos Impatientis 40 ~ 60 parts, olea europaea fruit 20 ~ 30 parts, Amygdalus communis Lamarck 15 ~ 30 parts.
The present invention utilizes advanced biotechnology, in conjunction with the theory of Chinese medical science of Chinese tradition, Inca inchi, Flos Impatientis, olea europaea fruit, Amygdalus communis Lamarck is effectively combined, and forms compound preparation, and it can be used as the active component of Islamic surfactant.This formula is the optimum formula that inventor obtains through creative work, collaborative onset between each component of formula.
Wherein, Inca inchi: also known as print with Semen arachidis hypogaeae, Plukenetia volubilis Linneo is the perennial woody climber oilseed plant of Euphorbiaceae.Containing abundant oil in its fruit, wherein more than 70% is unsaturated fatty acid, can strengthen skin histology adhesion, repairs sebum film, strengthens the barrier function of epidermis.Reduce transdermal dehydration, improve the moisturizing rate of skin, soft skin, increase elasticity, reduce the generation of scytitis, improve pachylosis, low and deep situation.Meanwhile, the natural Vitamin E (tocopherol) of high-load gives again its good scavenging activated oxygen, antidotal function.
Flos Impatientis: sweet in the mouth, hardship, slightly warm in nature; There is expelling wind and removing dampness, promoting blood circulation and stopping pain, the effects such as removing toxic substances parasite killing.Main air wets disabled wilted limbs, waist side of body pain, and women closes stomachache, postnatal blood stasis not to the greatest extent, traumatic injury, fracture, skin sore, venom, leucorrhea, fungal infection of hand and foot, tinea unguium.
Olea europaea fruit: olive tree fruit, meridian distribution of property and flavor: bitter, cold.Enter liver, the heart two warp; Effect: suppressing the hyperactive liver and subsiding YANG, heat-clearing and toxic substances removing.For syndrome of upper hyperactivity of liver yang, burn and scald; There is the functions such as slow down aging, radioprotective, facilitating digestion system.
Amygdalus communis Lamarck: Amygdalus communis Lamarck has another name called Amygdaluscommunis L., is also commonly called as shell Semen Armeniacae Amarum, is the dry fruit that the Xinjiang Uygur people value most, is rich in multiple nutritional components.Amygdalus communis Lamarck has calms the nerves, and has one's ideas straightened out, brain-strengthening, improving eyesight kidney tonifying, lung moistening, intestine moistening, spermatogenesis, body-building, the functions such as stomach invigorating.Cure mainly cardiopalmus to breath with cough, deficiency of kidney-QI, soreness of the waist and knees, the diseases such as sexual impotence frequent micturition.
Further, the invention provides a kind of method preparing described Islamic plant composition for skin care, it is characterized in that, comprise the following steps:
(1) take each crude drug respectively according to described weight portion, after being pulverized by crude drug, mix homogeneously, obtains vegetable composition;
(2) in vegetable composition, add concentration of volume percent is that 60% ~ 95% ethanol carries out supersound extraction, obtains supersound extraction liquid;
(3) filter after supersound extraction liquid being left standstill, obtain filtrate;
(4) add in filtrate 1,3 butylene glycol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, collect filtrate, to obtain final product.
In the present invention, preferably, the pulverizing described in step (1) is for being crushed to 80 ~ 120 orders; In step (2), the ratio of vegetable composition quality and 60% ~ 95% ethanol contend is 1:10 ~ 1:30, g/mL; The condition of described supersound extraction is: Extracting temperature is 40 DEG C ~ 70 DEG C, and the time is 0.5 ~ 2h, and ultrasonic power is 300 ~ 500W; The concrete steps of step (3) are: stop heating to supersound extraction liquid, and supersound extraction liquid is left standstill 2 ~ 4 hours, and 100 ~ 200 orders obtain filtrate after filtering; The concrete steps of step (4) are: add in filtrate with the isopyknic 1,3 butylene glycol of 60% ~ 95% ethanol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
Further, the invention provides a kind of Islamic plant cream frost, it is characterized in that, described Islamic plant cream frost is made up of the raw material of following percentage by weight:
In the present invention, preferably, described emulsifying agent is cetearyl alcohol/Coco-Glucoside; Described thickening agent is xanthan gum; Described skin conditioning agent to be mass fraction be 1% HA solution (hyaluronate sodium); Described metal-chelator is EDETATE SODIUM; Described antiseptic is selected from least one in methyl parahydroxybenzoate, propyl p-hydroxybenzoate, propylene glycol/Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate/sodium chloride, phenoxyethanol/Sensiva SC50 and p-Hydroxybenzoic acid isobutyl ester.
In the present invention, preferably, described plant extract adopts following methods to prepare:
(1) take each crude drug according to following weight parts, Inca inchi 30 ~ 60 parts, Flos Impatientis 20 ~ 60 parts, olea europaea fruit 10 ~ 30 parts, Amygdalus communis Lamarck 10 ~ 30 parts, after being pulverized by crude drug, mix homogeneously, obtains vegetable composition;
(2) in vegetable composition, add concentration of volume percent is that 60% ~ 95% ethanol carries out supersound extraction, obtains supersound extraction liquid;
(3) filter after supersound extraction liquid being left standstill, obtain filtrate;
(4) add in filtrate 1,3 butylene glycol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, collect filtrate, to obtain final product.
In the present invention, preferably, in step (1), the weight portion of each crude drug is: Inca inchi 40 ~ 60 parts, Flos Impatientis 40 ~ 60 parts, olea europaea fruit 20 ~ 30 parts, Amygdalus communis Lamarck 15 ~ 30 parts, and described pulverizing is for being crushed to 80 ~ 120 orders; In step (2), the ratio of vegetable composition quality and 60% ~ 95% ethanol contend is 1:10 ~ 1:30, g/mL; The condition of described supersound extraction is: Extracting temperature is 40 DEG C ~ 70 DEG C, and the time is 0.5 ~ 2h, and ultrasonic power is 300 ~ 500W; The concrete steps of step (3) are: stop heating to supersound extraction liquid, and supersound extraction liquid is left standstill 2 ~ 4 hours, and 100 ~ 200 orders obtain filtrate after filtering; The concrete steps of step (4) are: add in filtrate with the isopyknic 1,3 butylene glycol of 60% ~ 95% ethanol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
Further, the invention provides a kind of method preparing described Islamic plant cream frost, it is characterized in that, comprise the following steps:
(1) butanediol in B phase, glycerol and thickening agent are stirred, stand-by;
(2) metal-chelator in B phase is added in deionized water, add the mixture of step (1) butanediol, glycerol and thickening agent after stirring, be heated to 80 ~ 85 DEG C, mixing;
(3) take A phase raw material successively, be heated to 80 ~ 85 DEG C, mixing;
(4) the A phase raw material that step (3) mixes all is joined in the B phase raw material that step (2) mixes, 2000 ~ 3000r/min, homogenizing 5 ~ 10min; Add C phase raw material, 4000 ~ 5000r/min, homogenizing 1 ~ 3min, start to stir cooling, stir speed (S.S.) 30 ~ 50r/min, rate of temperature fall is 1 ~ 2 DEG C/min;
(5) when temperature drops to 45 ~ 50 DEG C, add D phase raw material, stir;
(6) when temperature drops to 40 ~ 45 DEG C, add E phase raw material, stir, continue to be cooled to less than 40 DEG C, to obtain final product.
Further, present invention also offers the application of described Islamic plant composition for skin care in preparation has the cosmetics controlling oil, scavenging free radicals and Red blood streak dispelling effect.
In the preferred embodiment of the invention, what above-mentioned raw materials and method prepared is Islamic plant cream frost.Different according to use approach, Islamic plant composition for skin care of the present invention obtains plant extract after extracting, it also can be made into other skin nursing preparations, as cream, elite, shampoo, hair conditioner etc., but be not limited to above-mentioned dosage form, various different external preparation can be made according to known method in skin nursing product industrial circle.
The preparation method of vegetable composition of the present invention is not limited to of the present invention, and in this area, other conventional methods also can realize described effect, and the inventive method is the better preparation method of inventor's recommendation.Plant cream frost of the present invention is the optimum formula that inventor obtains through creative work, collaborative onset between each component of formula.Raw material used in the present invention and raw material sources are in table 2, and product quality and raw material sources all meet Islamic standard.
Cream frost recommendation method of the present invention is: after cleaning skin every day, gets appropriate cream frost uniform application in skin, is massaged into gently and absorbs completely.
Compared with prior art, beneficial effect of the present invention is embodied in:
Raw material selection natural plant composition of the present invention, non-stimulated to skin safe, plant extract itself not only has the effects such as control oil, scavenging free radicals and Red blood streak dispelling, also has the effect such as moisturizing, slow down aging.Raw material of the present invention obtains easily, preparation method is easy, green safety, and the crowd that is easy to accepts, and has good application prospect and market prospect.
Accompanying drawing explanation
Fig. 1 be 3 volunteers laser-Doppler picture before and after comparison diagram, wherein, left figure in Fig. 1 is respectively the laser-Doppler picture before No. 1, No. 2 and the experiment of 3 st volunteer, and right figure is respectively the laser-Doppler picture after No. 1, No. 2 and the experiment of 3 st volunteer;
Fig. 2 is that cream of the present invention frost removes DPPH free radical testing result figure;
Fig. 3 is the rate of change comparison diagram using cream of the present invention frost and matched group test section skin oil and fat content;
Fig. 4 is the relative change rate's comparison diagram using cream of the present invention frost and matched group test section skin oil and fat content; Wherein, *: p<0.05.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.But these embodiments are only exemplary, do not form any restriction to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments and replacement all fall within the scope of protection of the present invention.
Following examples medical material used all can be bought from China Medicament Group Corp. and obtain, and meets Pharmacopoeia of People's Republic of China 2005 editions standards.Other raw materials all obtain by commercially available purchase, and the instrument title that the present invention is used and producer are as table 1, and the present invention uses the source of raw material in table 2.
Table 1
| Title | Model | Producer |
| Ultraviolet-uisible spectrophotometer | UV2300 | Beijing Pu Xi all purpose instrument company limited |
| Ultrasound wave circulation extractor | SCIENTZ-HF5000 | Henan brother instrument and equipment company limited |
| Revolve steam generator | RE-6000A | Shanghai Yarong Biochemical Instrument Plant |
| Electricity pottery stove | LC-E013S | Official loyal to his sovereign Electric company |
| Agitator | Powerful control type-the vica of Eurostar | IKA company of Germany |
| Dispersion machine | T 25 digital display | IKA company of Germany |
| Control oily tester | 4K15 | Sigma company |
| Electronic balance | METTLER ML3002 | Mei Tele company |
| Doppler flowmeter | PeriScan PIM3 | Pa Rui medical science and technology company |
Table 2
The preparation of embodiment 1 Islamic plant composition for skin care of the present invention
Each crude drug is taken: Inca inchi 60g, Flos Impatientis 60g, olea europaea fruit 10g, Amygdalus communis Lamarck 20g by following weight; Above-mentioned each crude drug is crushed to 120 orders, mix homogeneously respectively, obtains vegetable composition; Adding concentration of volume percent to above-mentioned vegetable composition is that 95% ethanol 4500ml carries out supersound extraction, obtain supersound extraction liquid, Extracting temperature is 60 DEG C, and the time is 2h, ultrasonic power is 500W, and the quality of described vegetable composition and the volume ratio (g/mL) of 95% ethanol are 1:30; Stop heating, supersound extraction liquid is left standstill 4 hours, after 200 mesh screen, obtains filtrate; Add 4500ml1 in filtrate, 3-butanediol (with 95% ethanol equal-volume) miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
The preparation of embodiment 2 Islamic plant composition for skin care of the present invention
Each crude drug is taken: Inca inchi 30g, Flos Impatientis 30g, olea europaea fruit 25g, Amygdalus communis Lamarck 30g by following weight; Above-mentioned each crude drug is crushed to 80 orders, mix homogeneously respectively, obtains vegetable composition; Adding concentration of volume percent to above-mentioned vegetable composition is that 60% ethanol 1150ml carries out supersound extraction, obtain supersound extraction liquid, Extracting temperature is 45 DEG C, time is 0.5h, ultrasonic power is 350W, and the quality of described vegetable composition and the volume ratio (g/mL) of 60% ethanol are 1:10; Stop heating, supersound extraction liquid is left standstill 2 hours, after 100 mesh screen, obtains filtrate; Add 1150ml1 in filtrate, 3-butanediol (with 60% ethanol equal-volume) miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
The preparation of embodiment 3 Islamic plant composition for skin care of the present invention
Each crude drug is taken: Inca inchi 50g, Flos Impatientis 40g, olea europaea fruit 20g, Amygdalus communis Lamarck 25g by following weight; Above-mentioned each crude drug is crushed to 80 orders, mix homogeneously respectively, obtains vegetable composition; Adding concentration of volume percent to above-mentioned vegetable composition is that 85% ethanol 2700ml carries out supersound extraction, obtain supersound extraction liquid, Extracting temperature is 70 DEG C, time is 1.5h, ultrasonic power is 450W, and the quality of described vegetable composition and the volume ratio (g/mL) of 85% ethanol are 1:20; Stop heating, supersound extraction liquid is left standstill 3.5 hours, after 150 mesh screen, obtains filtrate; Add 2700ml1 in filtrate, 3-butanediol (with 85% ethanol equal-volume) miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
The preparation of embodiment 4 cream frost of the present invention
Raw material and proportioning (mass percent), in table 3:
Table 3
The preparation of plant extract in D phase:
(1) according to following weight parts weighting raw materials;
Inca inchi 50g, Flos Impatientis 40g, olea europaea fruit 20g, Amygdalus communis Lamarck 25g, be crushed to 80 orders respectively, mix homogeneously, obtain vegetable composition;
(2) in above-mentioned vegetable composition, add concentration of volume percent is that 85% ethanol 3375ml carries out supersound extraction, obtain supersound extraction liquid, Extracting temperature is 50 DEG C, time is 1h, ultrasonic power is 450W, and the quality of described vegetable composition and the volume ratio (g/mL) of 85% ethanol are 1:25;
(3) stop heating, supersound extraction liquid step (2) prepared leaves standstill 3.5 hours, and 150 orders obtain filtrate after filtering; Add 3375ml1 in filtrate, 3-butanediol (with 85% ethanol equal-volume) miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
Cream frost preparation method:
(1) butanediol in B phase, glycerol and xanthan gum are stirred, stand-by;
(2) EDETATE SODIUM in B phase is added in deionized water, add the mixture of step (1) butanediol, glycerol and xanthan gum after stirring, be heated to 80 ~ 85 DEG C, mixing;
(3) take A phase raw material successively, be heated to 80 ~ 85 DEG C, mixing;
(4) the A phase raw material that step (3) mixes all is joined in the B phase raw material that step (2) mixes, 2000 ~ 3000r/min, homogenizing 5 ~ 10min; Add C phase raw material, 4000 ~ 5000r/min, homogenizing 1 ~ 3min, start to stir cooling, stir speed (S.S.) 30 ~ 50r/min, rate of temperature fall is 1 ~ 2 DEG C/min;
(5) when temperature drops to 45 ~ 50 DEG C, add D phase raw material, stir;
(6) when temperature drops to 40 ~ 45 DEG C, add E phase raw material, stir, continue to be cooled to less than 40 DEG C, obtain cream frost.
The preparation of embodiment 5 cream frost of the present invention
Raw material and proportioning (mass percent), in table 4:
Table 4
The preparation of plant extract in D phase:
(1) according to following weight parts weighting raw materials;
Inca inchi 30g, Flos Impatientis 30g, olea europaea fruit 25g, Amygdalus communis Lamarck 30g; Above-mentioned each crude drug is crushed to 120 orders, mix homogeneously respectively, obtains vegetable composition;
(2) in above-mentioned vegetable composition, add concentration of volume percent is that 60% ethanol 1725ml carries out supersound extraction, obtain supersound extraction liquid, Extracting temperature is 70 DEG C, time is 1.5h, ultrasonic power is 300W, and the quality of described vegetable composition and the volume ratio (g/mL) of 60% ethanol are 1:15;
(3) stop heating, supersound extraction liquid step (2) prepared leaves standstill 2 hours, and 100 orders obtain filtrate after filtering; Add 1725ml1 in filtrate, after 3-butanediol miscible evenly (with 60% ethanol equal-volume), revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
Cream frost preparation method:
(1) butanediol in B phase, glycerol and xanthan gum are stirred, stand-by;
(2) EDETATE SODIUM in B phase is added in deionized water, add the mixture of step (1) butanediol, glycerol and xanthan gum after stirring, be heated to 80 ~ 85 DEG C, mixing;
(3) take A phase raw material successively, be heated to 80 ~ 85 DEG C, mixing;
(4) the A phase raw material that step (3) mixes all is joined in the B phase raw material that step (2) mixes, 2000 ~ 3000r/min, homogenizing 5 ~ 10min; Add C phase raw material, 4000 ~ 5000r/min, homogenizing 1 ~ 3min, start to stir cooling, stir speed (S.S.) 30 ~ 50r/min, rate of temperature fall is 1 ~ 2 DEG C/min;
(5) when temperature drops to 45 ~ 50 DEG C, add D phase raw material, stir;
(6) when temperature drops to 40 ~ 45 DEG C, add E phase raw material, stir, continue to be cooled to less than 40 DEG C, obtain cream frost.
The preparation of embodiment 6 cream frost of the present invention
Raw material and proportioning (mass percent), in table 5:
Table 5
The preparation of plant extract in D phase:
(1) according to following weight parts weighting raw materials;
Inca inchi 60g, Flos Impatientis 60g, olea europaea fruit 10g, Amygdalus communis Lamarck 20g; Above-mentioned each crude drug is crushed to 80 orders, mix homogeneously respectively, obtains vegetable composition;
(2) in above-mentioned vegetable composition, add concentration of volume percent is that 95% ethanol 3000ml carries out supersound extraction, obtain supersound extraction liquid, Extracting temperature is 40 DEG C, time is 2h, ultrasonic power is 500W, and the quality of described vegetable composition and the volume ratio (g/mL) of 95% ethanol are 1:20;
(3) stop heating, supersound extraction liquid step (2) prepared leaves standstill 4 hours, and 200 orders obtain filtrate after filtering; Add 3000ml1 in filtrate, 3-butanediol (with 95% ethanol equal-volume) miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
Cream frost preparation method:
(1) butanediol in B phase, glycerol and xanthan gum are stirred, stand-by;
(2) EDETATE SODIUM in B phase is added in deionized water, add the mixture of step (1) butanediol, glycerol and xanthan gum after stirring, be heated to 80 ~ 85 DEG C, mixing;
(3) take A phase raw material successively, be heated to 80 ~ 85 DEG C, mixing;
(4) the A phase raw material that step (3) mixes all is joined in the B phase raw material that step (2) mixes, 2000 ~ 3000r/min, homogenizing 5 ~ 10min; Add C phase raw material, 4000 ~ 5000r/min, homogenizing 1 ~ 3min, start to stir cooling, stir speed (S.S.) 30 ~ 50r/min, rate of temperature fall is 1 ~ 2 DEG C/min;
(5) when temperature drops to 45 ~ 50 DEG C, add D phase raw material, stir;
(6) when temperature drops to 40 ~ 45 DEG C, add E phase raw material, stir, continue to be cooled to less than 40 DEG C, obtain cream frost.
The preparation of embodiment 7 cream frost of the present invention
Raw material and proportioning (mass percent), in table 6:
Table 6
The preparation of plant extract in D phase:
(1) according to following weight parts weighting raw materials;
Inca inchi 45g, Flos Impatientis 20g, olea europaea fruit 16g, Amygdalus communis Lamarck 14g, be crushed to 100 orders respectively, mix homogeneously, obtain vegetable composition;
(2) in above-mentioned vegetable composition, add percent by volume is that 80% ethanol 2850ml carries out supersound extraction, obtain supersound extraction liquid, Extracting temperature is 65 DEG C, time is 2h, ultrasonic power is 400W, and the quality of described vegetable composition and the volume ratio (g/mL) of 80% ethanol are 1:30;
(3) stop heating, supersound extraction liquid step (2) prepared leaves standstill 3 hours, and 100 orders obtain filtrate after filtering; Add 2850ml1 in filtrate, 3-butanediol (with 80% ethanol equal-volume) miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
Cream frost preparation method:
(1) butanediol in B phase, glycerol and xanthan gum are stirred, stand-by;
(2) EDETATE SODIUM in B phase is added in deionized water, add the mixture of step (1) butanediol, glycerol and xanthan gum after stirring, be heated to 80 ~ 85 DEG C, mixing;
(3) take A phase raw material successively, be heated to 80 ~ 85 DEG C, mixing;
(4) the A phase raw material that step (3) mixes all is joined in the B phase raw material that step (2) mixes, 2000 ~ 3000r/min, homogenizing 5 ~ 10min; Add C phase raw material, 4000 ~ 5000r/min, homogenizing 1 ~ 3min, start to stir cooling, stir speed (S.S.) 30 ~ 50r/min, rate of temperature fall is 1 ~ 2 DEG C/min;
(5) when temperature drops to 45 ~ 50 DEG C, add D phase raw material, stir;
(6) when temperature drops to 40 ~ 45 DEG C, add E phase raw material, stir, continue to be cooled to less than 40 DEG C, obtain cream frost.
The Efficacy experiments of test example 1 Islamic plant of the present invention cream frost
One, Red blood streak dispelling effect
1, experimental principle
Doppler flowmeter
Laser doppler technique is a kind of unique technology of monitoring tissue blood flow continuously.When the hemocyte etc. moved in monochromatic laser beam and blood flow interacts, according to Doppler effect, reflected light frequency changes, and the increase and decrease of this frequency is relevant with blood flow direction and flow velocity (being proportional to the quantity by the hemocyte of certain vascular cross-section in the unit interval) with the size of knots modification.Detector on probe can detect these small changes, and in systems in which store, analyzing and processing, the image of last synthetic reaction blood circumstance.
2, experiment content
1. choosing 30 volunteers uses cleansing milk to clean face skin, after clean skin 22 ± 1 DEG C, sit quietly in the constant-humidity constant-temperature laboratory of 50 ± 5% moistures 20min;
2. the data such as volunteer's background values and picture are measured successively;
3. volunteer was according to the cold cream frost using separately embodiment 4 in the present invention accustomed to using of astringent cream frost to prepare 30 days, and every day respectively smears once sooner or later;
4. use cream frost after 30 days, volunteer, according to survey background values data method, again measures and uses the data such as numerical value and picture after product;
5. volunteer is according to the effect of use product after 30 days, fills in relevant investigation questionnaire, reclaims questionnaire and add up corresponding data, carrying out data analysis;
6. according to data and picture analyzing.
3, interpretation of result
1. 30 parts of statistics questionnaire investigation results, what volunteer obviously can feel that red blood trace on face amount reduces is 78%, and red blood streak quantity has minimizing but is not especially significantly account for 19%, and red blood streak quantity and vicissitudinously do not account for 3%.
2. doppler flowmeter data results (get 3 volunteers and test shooting image)
3 volunteers test shooting image and see Fig. 1, wherein, left figure in Fig. 1 is respectively the laser-Doppler picture before No. 1, No. 2 and the experiment of 3 st volunteer, the laser-Doppler picture (using the cream frost of embodiment 4 preparation after 30 days) after right figure is respectively No. 1, No. 2 and the experiment of 3 st volunteer, in Fig. 1, black region area is larger, shows that blood perfusion amount is lower.Carry out data analysis according to Fig. 1, concrete analysis the results are shown in Table 7.
Comparing result before and after table 7 volunteer laser-Doppler picture
From Fig. 1 and table 7, after using product of the present invention, blood perfusion amount obviously reduces before comparatively using product, after using product, skin Average baseline value has reduction before comparatively using, this shows that test sample of the present invention has the effect reducing skin microcirculation, thus reduces visual blood capillary quantity to reach effect of Red blood streak dispelling.
Two, scavenging free radicals effect
1, experimental principle
DPPH (1,1-disphenyl-2-picry1-hydrazy1), chemical name is 1,1-diphenyl-2-trinitrophenyl-hydrazine, and molecular formula is (C
6h
5)
2n-NC
6h
5(NO
2)
3, on nitrogen bridge atom, have the valency electron that is not paired in this compound, and the orbital motion of this electronics almost offset by molecular structure, usually to catch the index of DPPH free radical as evaluation oxidation resistance.The reaction mechanism of concrete DPPH free radical as shown in the formula:
2, experimental apparatus and sample
Experimental apparatus: ultraviolet-uisible spectrophotometer; Analytical balance.
Sample: cream frost prepared by embodiment 4.
Positive control: vitamin C (vitamin C is a kind of antioxidant, and protection health avoids the threat of free radical).
Get 0.1g vitamin C, add water and be settled to 100ml, be the vitamin c solution of 0.01%.
3, experimental technique
1) liquid to be measured of 1mL and 2 × 10 of 1mL are got
-4the DPPH solution mixing (A of mol/L
1pipe);
2) dehydrated alcohol of 1mL and 2 × 10 of 1mL are got
-4the DPPH solution mixing (A of mol/L
2pipe);
3) liquid to be measured of the dehydrated alcohol and 1mL of getting 1mL mixes (A3 manages);
4), after reacting 30min, under 517nm, A is surveyed
1, A
2, A
3pipe absorbance.
Table 8
| Numbering | DPPH solution | Dehydrated alcohol | Cream frost | Cumulative volume |
| A 1 | 1.0mL | —— | 1.0mL | 2mL |
| A 2 | 1.0mL | 1.0mL | —— | 2mL |
| A 3 | —— | 1.0mL | 1.0mL | 2mL |
4, interpretation of result
Clearance rate computing formula is: clearance rate (%)=[(A
2+ A
3)-A
1]/A
2
Analyze: wherein positive control is vitamin C.
Clearance rate is in effective range as seen from Figure 2, and the clearance rate of sample, in effective range (0-100%), namely has the effect removing DPPH free radical, and larger, and effect is better.
Therefore, sample has the effect removing DPPH free radical.
Three, oily effect is controlled
1, experimental principle
Human experimentation, forms test population by particular experiment crowd (Moslem crowd), and test subject uses the change of skin oil and fat content before and after cream frost, thus deterministic cosmetic (or functional component) press down fat effect.
2, experimental apparatus and sample
Experimental apparatus: skin oil and fat tester
sM815.
Laboratory sample: cream frost prepared by embodiment 4.
Blank group: namely do not smear any product, contrasts with laboratory sample group by measuring skin secretion oils and fats data, to determine laboratory sample group control oil effect.
3, Subject Population
Experimenter amounts to 30 people.Concrete sex composition and age structure are determined at random.If period has 2 people to occur untoward reaction, then stop test; Result does not find untoward reaction.
4, experimental technique
1. experimenter's forehead labelling is selected.
2. technical staff uses skin oil and fat tester
3 times, SM815 test test position, averages, is designated as initial value.
3. experimenter tries out sample and smears forehead region, and test period can not smear other the control oil product controlling oily effect.
4. experimenter after continuously using cream frost first week, second week, after 4th week, use skin oil and fat tester by technical staff
sM815 measures 3 times, averages.
5. add up the numerical value recorded, analyze its skin oil and fat changes of contents rule.
5, results and analysis
Within test period, this test event is screened 30 people altogether and is included research in, comes off without between group, and does not occur the skin irritation of obvious systemic adverse reactions or more than 3 grades in tested crowd, therefore effective volunteer's number of this test is 30 people.
△＝Tn-T0
Rate of change (%)=((Tn-T0)/T0) × 100, this value is lower, and it is fewer that skin secretes oil quantity in time.
Relative change rate (%)=(((Tn-T0)-(KTn-KT0))/T0) × 100, this value is lower, and relative comparison group is described, test section skin oil and fat content is fewer.
In formula, Tn---tested region changes numerical value in time
T0---tested region initial value
KTn---white space changes numerical value in time
KT0---white space initial value
Rate of change value and the relative change rate of skin oil and fat content see Fig. 3 and Fig. 4.
As seen from Figure 3, within 4 weeks test periods, after experimenter uses test sample, test section skin oil and fat content is all in rising trend, but rate of change lower than matched group, illustrates that test section skin oil and fat content is less than matched group at the 1st week, the 2nd week and the 4th Zhou Shijun.
As seen from Figure 4, within 4 weeks test periods, after experimenter uses test sample, skin oil and fat content equal relative change rate in test section is negative value when the 1st week, the 2nd week and the 4th week, illustrate that test section skin oil and fat content is less than matched group, and there is significant difference (p<0.05) when the 4th week, namely sample has the oily effect of control.
Four, human body patch test
1, test objective
Human trial, forms test population by special test crowd (Moslem crowd), and test subject makes to apply some make up and causes the probability of human body skin untoward reaction before and after (and cosmetic industry composition).
2, test material
Speckle examination device: Beijing North doctor management of investment company limited produces, circular, diameter 12mm.
Speckle examination thing: cream frost 0.025g prepared by Example 4.
3, crowd and testing time is tested
Effective experimenter amounts to 30 people, and concrete sex composition and age structure are determined at random (meets that 2007 " cosmetics health specifications " are included in, exclusion standard.
The test time started: on 07 06th, 2015 on 07 08th, 2015.
4, test method
1. press subject enrollment Standard Selection subject, number is 30 examples.
2. select qualified patch material, sample is put into speckle examination device (amount of samples is 0.020g ~ 0.025g), control wells is blank (declining any material).Sample and blank are all affixed on the bent side of forearm of experimenter, gently press with palm and make it to stick equably on skin, continue 24h.
3. interval 30min after removal patch device, observes dermoreaction after impression disappears.
4. after patch test, 24h and 48h observes once respectively again, observes dermoreaction.
5. skin adverse reaction grade scale is in table 9.
The classification of table 9 skin adverse reaction
5, result of the test
Table 10 takes out patch device 0.5 hour observed result
Speckle examination device 24 hours observed results removed by table 11
Speckle examination device 48 hours observed results removed by table 12
Explain according to skin enclosed type patch test results: in 30 routine experimenters, occur that the number of 1 grade of skin adverse reaction is more than 5 examples, or the number of 2 grades of skin adverse reactions is more than 2 examples, or when there is any 1 example more than 3 grades or 3 grades skin adverse reactions, judge that tested material has untoward reaction to human body.
Skin enclosed type patch test results is in table 10,11 and 12, and according to result display, inventive samples has no adverse reaction to human body skin.The sample that inventor utilizes other embodiments to prepare repeats above-mentioned test, and result of the test, with above-mentioned, all has no adverse reaction to human body skin.
Claims (10)
1. an Islamic plant composition for skin care, is characterized in that, is made up of the crude drug of following weight portion: Inca inchi 30 ~ 60 parts, Flos Impatientis 20 ~ 60 parts, olea europaea fruit 10 ~ 30 parts, Amygdalus communis Lamarck 10 ~ 30 parts.
2. Islamic plant composition for skin care according to claim 1, is characterized in that, the weight portion of each crude drug is: Inca inchi 40 ~ 60 parts, Flos Impatientis 40 ~ 60 parts, olea europaea fruit 20 ~ 30 parts, Amygdalus communis Lamarck 15 ~ 30 parts.
3. prepare a method for the Islamic plant composition for skin care described in claim 1 or 2, it is characterized in that, comprise the following steps:
(1) take each crude drug respectively according to described weight portion, after being pulverized by crude drug, mix homogeneously, obtains vegetable composition;
(2) in vegetable composition, add concentration of volume percent is that 60% ~ 95% ethanol carries out supersound extraction, obtains supersound extraction liquid;
(3) filter after supersound extraction liquid being left standstill, obtain filtrate;
(4) add in filtrate 1,3 butylene glycol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, collect filtrate, to obtain final product.
4. method according to claim 3, is characterized in that, the pulverizing described in step (1) is for being crushed to 80 ~ 120 orders; In step (2), the ratio of vegetable composition quality and 60% ~ 95% ethanol contend is 1:10 ~ 1:30, g/mL; The condition of described supersound extraction is: Extracting temperature is 40 DEG C ~ 70 DEG C, and the time is 0.5-2h, and ultrasonic power is 300 ~ 500W; The concrete steps of step (3) are: stop heating to supersound extraction liquid, and supersound extraction liquid is left standstill 2 ~ 4 hours, and 100 ~ 200 orders obtain filtrate after filtering; The concrete steps of step (4) are: add in filtrate with the isopyknic 1,3 butylene glycol of 60% ~ 95% ethanol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
5. an Islamic plant cream frost, is characterized in that, described Islamic plant cream frost is made up of the raw material of following percentage by weight:
6. Islamic plant cream frost according to claim 5, it is characterized in that, described emulsifying agent is cetearyl alcohol/Coco-Glucoside; Described thickening agent is xanthan gum; Described skin conditioning agent to be mass fraction be 1% HA solution; Described metal-chelator is EDETATE SODIUM; Described antiseptic is selected from least one in methyl parahydroxybenzoate, propyl p-hydroxybenzoate, propylene glycol/Methylisothiazolinone/iodine propilolic alcohol butyl mephenesin Carbamate/sodium chloride, phenoxyethanol/Sensiva SC50 and p-Hydroxybenzoic acid isobutyl ester.
7. Islamic plant cream frost according to claim 5, is characterized in that, described plant extract adopts following methods to prepare:
(1) take each crude drug according to following weight parts, Inca inchi 30 ~ 60 parts, Flos Impatientis 20 ~ 60 parts, olea europaea fruit 10 ~ 30 parts, Amygdalus communis Lamarck 10 ~ 30 parts, after being pulverized by crude drug, mix homogeneously, obtains vegetable composition;
(2) in vegetable composition, add concentration of volume percent is that 60% ~ 95% ethanol carries out supersound extraction, obtains supersound extraction liquid;
(3) filter after supersound extraction liquid being left standstill, obtain filtrate;
(4) add in filtrate 1,3 butylene glycol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, collect filtrate, to obtain final product.
8. Islamic plant cream frost according to claim 7, it is characterized in that, in step (1), the weight portion of each crude drug is: Inca inchi 40 ~ 60 parts, Flos Impatientis 40 ~ 60 parts, olea europaea fruit 20 ~ 30 parts, Amygdalus communis Lamarck 15 ~ 30 parts, and described pulverizing is for being crushed to 80 ~ 120 orders; In step (2), the ratio of vegetable composition quality and 60% ~ 95% ethanol contend is 1:10 ~ 1:30, g/mL; The condition of described supersound extraction is: Extracting temperature is 40 DEG C ~ 70 DEG C, and the time is 0.5 ~ 2h, and ultrasonic power is 300 ~ 500W; The concrete steps of step (3) are: stop heating to supersound extraction liquid, and supersound extraction liquid is left standstill 2 ~ 4 hours, and 100 ~ 200 orders obtain filtrate after filtering; The concrete steps of step (4) are: add in filtrate with the isopyknic 1,3 butylene glycol of 60% ~ 95% ethanol miscible evenly after, revolve the ethanol steamed in solution, vacuum filtration, vacuum is 0.06 ~ 0.1MPa, collects filtrate, to obtain final product.
9. prepare a method for Islamic plant cream frost according to claim 5, it is characterized in that, comprise the following steps:
(1) butanediol in B phase, glycerol and thickening agent are stirred, stand-by;
(2) metal-chelator in B phase is added in deionized water, add the mixture of step (1) butanediol, glycerol and thickening agent after stirring, be heated to 80 ~ 85 DEG C, mixing;
(3) take A phase raw material successively, be heated to 80 ~ 85 DEG C, mixing;
(4) the A phase raw material that step (3) mixes all is joined in the B phase raw material that step (2) mixes, 2000 ~ 3000r/min, homogenizing 5 ~ 10min; Add C phase raw material, 4000 ~ 5000r/min, homogenizing 1 ~ 3min, start to stir cooling, stir speed (S.S.) 30 ~ 50r/min, rate of temperature fall is 1 ~ 2 DEG C/min;
(5) when temperature drops to 45 ~ 50 DEG C, add D phase raw material, stir;
(6) when temperature drops to 40 ~ 45 DEG C, add E phase raw material, stir, continue to be cooled to less than 40 DEG C, to obtain final product.
10. the Islamic plant composition for skin care described in claim 1 or 2 has the application in the cosmetics of control oil, scavenging free radicals and Red blood streak dispelling effect in preparation.
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