CN104771335B - Anti-dandruff nourishing essence dew of plant and preparation method thereof - Google Patents
Anti-dandruff nourishing essence dew of plant and preparation method thereof Download PDFInfo
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- CN104771335B CN104771335B CN201410017343.9A CN201410017343A CN104771335B CN 104771335 B CN104771335 B CN 104771335B CN 201410017343 A CN201410017343 A CN 201410017343A CN 104771335 B CN104771335 B CN 104771335B
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Abstract
The invention provides anti-dandruff nourishing essence dew of a kind of plant and preparation method thereof.The anti-dandruff nourishing essence dew of plant of the present invention, includes water, ethanol, butanediol, glycerine, glycine betaine, kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, tetrahydrochysene pipering, Sodium Hyaluronate, xanthans, Phenoxyethanol and Sensiva SC50.Contain the active ingredient extracted using modern plants extractive technique from the plants such as kuh-seng, the root bark of shaggy-fruited dittany, Radix Angelicae Sinensis, improve scalp microenvironment, improve scalp vigor, reduce the generation that dandruff and head are itched.
Description
Technical field
The present invention relates to anti-dandruff nourishing essence dew of a kind of plant and preparation method thereof.
Background technology
There is the shampoo of various brands on the market, there is various effect, it is anti-dandruff, antipruritic, submissive etc., there is dandruff
People will select with raise scalp function shampoo.Some shampoos just start with also relatively effectively, the time has been grown just not
Effective, reason, which is that chemistry is anti-dandruff, only rests on surface cleaning, it is impossible to thoroughly eradicates dandruff, chemical composition is remained in head on the contrary
Pi Shang, scalp is caused further to be stimulated and injured.The content of the invention
It is an object of the invention to provide anti-dandruff nourishing essence dew of a kind of plant and preparation method thereof.
The anti-dandruff nourishing essence dew of plant provided by the present invention, by water, ethanol, butanediol, glycerine, glycine betaine, radix sophorae
Extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, four
Hydrogen pipering, Sodium Hyaluronate, xanthans, Phenoxyethanol and Sensiva SC50 composition.
Wherein, the weight/mass percentage composition of the ethanol is 10-50%, and the weight/mass percentage composition of the water is 24.125-
84.825%, the butanediol weight/mass percentage composition is 2-10%, and the weight/mass percentage composition of the glycerine is 1-5%, the glycine betaine
Weight/mass percentage composition be 1-5%, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder
Total percentage composition with cnidium monnieri berry extract is 0.5-2.5%, and the weight/mass percentage composition of the panthenol is 0.2-1%, the radix glycyrrhizae
The weight/mass percentage composition of sour dipotassium is 0.2-1%, and the weight/mass percentage composition of the tetrahydrochysene pipering is 0.05-0.25%, described
The weight/mass percentage composition of bright matter acid sodium is 0.005-0.025%, and the weight/mass percentage composition of the xanthans is 0.02-0.1%, described
Phenoxyethanol, the weight/mass percentage composition of Sensiva SC50 are 0.2-1%.
In the above-mentioned anti-dandruff nourishing essence dew of plant, it is preferred that the weight/mass percentage composition of the ethanol is 32%, the water
Weight/mass percentage composition is 52.83%, and the butanediol weight/mass percentage composition is 5%, and the weight/mass percentage composition of the glycerine is 3.5%,
The weight/mass percentage composition of the glycine betaine is 3%, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, upright
Total percentage composition of RADIX STEMONAE powder and cnidium monnieri berry extract is 2%, and the weight/mass percentage composition of the panthenol is 0.5%, the radix glycyrrhizae
The weight/mass percentage composition of sour dipotassium is 0.5%, and the weight/mass percentage composition of the tetrahydrochysene pipering is 0.1%, the Sodium Hyaluronate
Weight/mass percentage composition be 0.01%, the weight/mass percentage composition of the xanthans is 0.06%, the Phenoxyethanol and ethylhexyl
The weight/mass percentage composition of glycerine is 0.5%.
Wherein, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder and cnidium monnieri fruit
The mass ratio of extract is 25%：20%：20%：20%：15%.
The preparation method of the anti-dandruff nourishing essence dew of plant provided by the present invention, comprises the following steps：
It is water, ethanol, butanediol, glycerine, glycine betaine, kuh-seng root extract, Cortex Dictamni extract, Angelica roots, straight
Vertical RADIX STEMONAE powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, tetrahydrochysene pipering, Sodium Hyaluronate, xanthans, Phenoxyethanol
Reveal with the well mixed anti-dandruff nourishing essence of plant that obtains of Sensiva SC50.
Wherein, the weight/mass percentage composition of the ethanol is 10-50%, and the weight/mass percentage composition of the water is 24.125-
84.825%, the butanediol weight/mass percentage composition is 2-10%, and the weight/mass percentage composition of the glycerine is 1-5%, the glycine betaine
Weight/mass percentage composition be 1-5%, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder
Total percentage composition with cnidium monnieri berry extract is 0.5-2.5%, and the weight/mass percentage composition of the panthenol is 0.2-1%, the radix glycyrrhizae
The weight/mass percentage composition of sour dipotassium is 0.2-1%, and the weight/mass percentage composition of the tetrahydrochysene pipering is 0.05-0.25%, described
The weight/mass percentage composition of bright matter acid sodium is 0.005-0.025%, and the weight/mass percentage composition of the xanthans is 0.02-0.1%, described
Phenoxyethanol, the weight/mass percentage composition of Sensiva SC50 are 0.2-1%.
In above-mentioned preparation method, it is preferred that the weight/mass percentage composition of the ethanol is 32%, and the quality percentage of the water contains
Measure as 52.83%, the butanediol weight/mass percentage composition is 5%, and the weight/mass percentage composition of the glycerine is 3.5%, the glycine betaine
Weight/mass percentage composition be 3%, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder and
Total percentage composition of cnidium monnieri berry extract is 2%, and the weight/mass percentage composition of the panthenol is 0.5%, the matter of the dipotassium glycyrrhizinate
It is 0.5% to measure percentage composition, and the weight/mass percentage composition of the tetrahydrochysene pipering is 0.1%, the quality percentage of the Sodium Hyaluronate
Content is 0.01%, and the weight/mass percentage composition of the xanthans is 0.06%, the quality of the Phenoxyethanol and Sensiva SC50
Percentage composition is 0.5%.
In one embodiment, it is preferred that, the preparation method of the anti-dandruff nourishing essence dew of plant comprises the following steps：
The preparation method of the anti-dandruff nourishing essence dew of plant comprises the following steps：
1）Stirring is opened simultaneously to addition water and ethanol in tank is made, is well mixed, it is standby；
2）Continue to stir saturating to solution to addition panthenol, glycine betaine and dipotassium glycyrrhizinate in tank is made one by one under agitation
It is bright, produce mixed solution a；
3）Uniform butanediol, tetrahydrochysene pipering, hyalomitome are pre-mixed to making to continuously add in in-tank mixing solution a
Sour sodium mixed solution；Stirring 30 minutes, produces mixed solution b；
4）Uniform xanthans and glycerine mixed solution are pre-mixed to making to add in in-tank mixing solution b.Stirring 30
Minute, produce mixed solution c；
5）Kuh-seng root extract, Cortex Dictamni extract, Angelica roots, straight is added in in-tank mixing solution c to making
Vertical RADIX STEMONAE powder and cnidium monnieri berry extract, stir 10 minutes, produce mixed solution d；
6）Preservative Phenoxyethanol and Sensiva SC50 are added in tank to making, stirs 10 minutes, it is anti-dandruff to produce plant
Nourishing essence reveals.
Wherein, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder and cnidium monnieri fruit
The mass ratio of extract is 25%：20%：20%：20%：15%.
The plant anti-dandruff nourishing essence dew of the present invention contains using modern plants extractive technique from kuh-seng, the root bark of shaggy-fruited dittany, Radix Angelicae Sinensis
Deng the active ingredient extracted in plant, improve scalp microenvironment, improve scalp vigor, reduce the generation that dandruff and head are itched.This hair
It is bright will nursing with anti-dandruff combination, have no side effect to scalp, make anti-dandruff effect more preferable, it is anti-dandruff more longlasting.
Brief description of the drawings
The preparation technology flow chart of the anti-dandruff nourishing essence dew of Fig. 1 plants of the present invention.
Embodiment
Material used in following embodiments：
Kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder and cnidium monnieri berry extract it is mixed
Compound is purchased from thousand careless bio tech ltd of Kunming, wherein kuh-seng root extract, Cortex Dictamni extract, Angelica roots,
The mass ratio of radix stemonae sessilifoliae root powder and cnidium monnieri berry extract is 25%：20%：20%：20%：15%.
Panthenol（Following is D-pantothenyl aleohol）：Dutch DSM Co., Ltd 0413852；
Dipotassium glycyrrhizinate：Shanghai Jia Ye Industrial Co., Ltd.s PS-0009；
Sodium Hyaluronate：Bloomage Freda Biopharm Co., Ltd. 9067-37-7；
Xanthans：French Rhodia 11138-66-2；
Phenoxyethanol：German Shu Mei Co., Ltds；
Sensiva SC50：German Shu Mei Co., Ltds；
Tetrahydrochysene pipering：：Sabinsa0496CH；
Embodiment 1,
In the present embodiment, the anti-dandruff nourishing essence dew of plant is extracted by water, ethanol, butanediol, glycerine, glycine betaine, radix sophorae
Thing, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, tetrahydrochysene are recklessly
Green pepper alkali, Sodium Hyaluronate, xanthans, Phenoxyethanol and Sensiva SC50 composition.
The specific anti-dandruff nourishing essence dew product form of plant is as shown in table 1.
Table 1.
The preparation method following steps of the anti-dandruff nourishing essence dew of plant：
1）1 to No. 12 raw material is weighed by the formula shown in table 1, it is standby.
2）According to the Feedstock Component content shown in 1 and No. 2 in table 1, open and stir simultaneously to addition water, ethanol in tank is made
Mix, be well mixed, it is standby.
3）According to the Feedstock Component content in table 1 shown in 8,5 and No. 9, under agitation one by one to make added in tank panthenol,
Glycine betaine, dipotassium glycyrrhizinate, stir transparent to solution, produce mixed solution a.
4）To making to add in tank uniform fourth is pre-mixed according to the Feedstock Component content in table 1 shown in 3,10 and No. 12
Glycol, tetrahydrochysene pipering, Sodium Hyaluronate mixed solution.Stirring 30 minutes, produces mixed solution b.
5）To making to add in tank uniform xanthan is pre-mixed according to the Feedstock Component content shown in 11 and No. 4 in table 1
Glue and glycerine mixed solution.Stirring 30 minutes, produces mixed solution c.
6）Extracted according to the Feedstock Component content shown in No. 6 in table 1 to addition kuh-seng root extract, the root bark of shaggy-fruited dittany in tank is made
Thing, Angelica roots, radix stemonae sessilifoliae root powder and cnidium monnieri berry extract.Stirring 10 minutes, produces mixed solution d.
7）According to the Feedstock Component content shown in No. 7 in table 1 preservative Phenoxyethanol and ethyl hexyl are added into making tank
Base glycerol.Stirring 10 minutes, produce the anti-dandruff nourishing essence dew semi-finished product of plant.
8）Filling, packaging after the anti-dandruff nourishing essence dew semi-finished product detection of plant is qualified, product inspection warehousing after passing, is produced
The anti-dandruff nourishing essence dew finished product of plant.
The application method and compliance test result of the anti-dandruff nourishing essence dew of plant：
【Application method】After hair washing, take appropriate this product to be uniformly applied to scalp, and suitably massage to promote to absorb.
【Points for attention】Avoid it is pleasing to the eye, if pleasing to the eye please being rinsed immediately with water accidentally；Shady place is positioned over, avoids children from grabbing
Take；Allergic constitution person uses with caution.
【Compliance test result】
1 materials and methods
1.1 main agents and instrument：Without the neutral shampoo of anti-dandruff and nourishing effect (the limited public affairs of ZHANGGUANG 101 science and technology share
Department provides）, the anti-dandruff scalp protective agent of Chinese medicine, SEBUMETER SM810 measuring instruments, Tewameter testers.
1.2 research object：Severe dandruff patient in 30, wherein male 4, women 26, average age 22.56 ±
3.42 year.
1.2.1 inclusion criteria：Total score is counted at 25 points according to international " ten grades of point systems of tackness dandruff " dandruff
Dandruff subject above.
1.1.2 exclusion standard：Meet above-mentioned inclusion criteria but merge other skin diseases, or system use in 2 weeks is anti-before Chinese medicine
The antipruritics such as histamine drug, glucocorticoid, antiandrogen preparation, estrogen, immunomodulator, antidepression class medicine and antimycotic
Class medicine history, or scalp external application glucocorticoid, cutin cracking-off agent, immunomodulator, antimycotic medicine and other treatment of dandruff
With the externally applied drug person of seborrhea;Used during Chinese medicine using other shampoos, hair conditioner, pour mask, treatment wax persons, or hair
The Hair Stying Products persons such as hair-dryer, straight panel folder;To testing with neutral shampoo allergy sufferers;Not strictly in accordance with experimental program person.
1.3 research contents
1.3.1 the phase is eluted：All subjects for intending participating in Chinese medicine unify neutrality of the use research offer without anti-dandruff component
Shampoo one week, have one's hair wash 1 time within average 1-3 days, have one's hair wash 1 time within 24 hours before experiment, it is desirable to which subject is in whole research cycle
Hair cleaning is carried out using the shampoo.
1.3.2 research method
1.3.2.1 blind is set and random coded processing:Using randomized double-blind blank research, third party will according to random table
Research object head on both sides（Using forehead hairline median line as boundary）It is divided into Chinese medicine side and blank side（Placebo）, and research is protected
Shield agent only marks subject's coding and left and right sides with protective agent with blank, gives researcher.
1.3.2.2 application method：It is required that subject is daily according to the bottled outer left and right sides for compiling note of protective agent by two kinds of scalps
Protective agent is uniformly applied to scalp left and right sides respectively, and once a day, service life is 4 weeks.
1.3.2.3 efficacy assessments：After the elution end of term, Chinese medicine 2 weeks, after 4 weeks, follow-up period carry out 4 evaluation and tests, evaluate and test content
Including symptom scores, skin barrier function determines two parts.
1.3.3 research contents
1.3.3.1 symptom scores
Scalp is divided into 6 regions（Left and right sides difference Qu E Ding Zhensange areas）, according to international " tackness head
Ten grades of point system notes of bits calculate dandruff score summation in selected viewing area.Dandruff standards of grading：0 point indicates no dandruff, 1-2
Be divided into the greyish white rough scales of small flakes, 3-4 points are as low as median size chip, 5-6 points be with loose be connected big of scalp and
Thin chip, 7-8 points are big tackness chip, and 9-10 points are the white thicker scales of skin that peel off to yellow with scalp close attachment.
With the forehead hairline median line point left and right sides, using subject's self-assessment method, self-appraisal content includes scalp oil
Greasy degree, itching of the scalp degree, the itching of the scalp frequency.
1.3.3.2 skin barrier function determines
It is required that 20 DEG C of laboratory temperature, air humidity 40%, subject is not engaged in strenuous exercise before functional examination in 1h,
Without dominant perspiration, and the 20min that sits quietly.
Measurement site takes at 4 points：With the forehead hairline median line point left and right sides, apart from scalp center line both sides about 3cm, apart from head
Skin anterior hair line 3cm chooses at 2 points, and horizontal scalp center line of boss parietal or so 3cm chooses at 2 points, and each measurement point is tested 3 times and taken repeatedly
Average value, forehead and top statistical average is taken to represent scalp barrier function average level.
Scalp fat secretion is determined using Sebumeter SM810 measuring instruments, Tewameter testers determine percutaneous moisture
Loss Rate.
1.3.3.3 safety evaluatio：According to《Cosmetics health specification》Normal individual trial Chinese medicine skin adverse reaction classification mark
Standard, respectively at mid-term on probation（2w）, try out latter stage（4w）, follow-up period monitoring product whether there is excitant.
1.3.4 data analysis
Data analysis is carried out using spss17.0 software kits, clinical efficacy scoring uses rank test, uses and match somebody with somebody between two groups
T is examined, with P<0.05 is significance test standard.
2 results
2.1 subject's ordinary circumstances：30 subjects are fully completed this research, have no adverse reaction, test preceding both sides and face
Bed evaluation and scalp barrier function have comparativity through statistical calculations no significant difference（P ＞ 0.05）.
Chinese medicine side and the comparison of blank side symptom scores（x±s）
Note：1. before experiment（0w）Compare no difference of science of statistics in both sides（P ＞ 0.05）,
2.Compared with same time blank side, both sides are compared with significant difference（P ＜ 0.05）.
2.2 Chinese medicine sides and the comparison of blank side symptom scores
Chinese medicine side is compared with blank side, Chinese medicine side research latter stage（4w）Dandruff total score is less than blank side, has conspicuousness
Difference（Z=- 2.265, P=0.024）, both sides itching of the scalp degree, the itch frequency, the greasy degree of scalp has no notable difference（P>
0.05）（Table 1）.
2.3 Chinese medicine sides and blank side scalp fat secretion, the comparison of percutaneous loss of moist rate
Latter stage is studied compared with blank side in Chinese medicine side（4w）, follow-up period（5w）Chinese medicine side fat secretion amount is reduced, and has system
Meter learns difference（P=0.006, P=0.004）.Study latter stage（4w）Both sides loss of moist rate has no notable difference, after disabling 1w, with
The visit phase（5w）Chinese medicine side loss of moist rate is less than blank side, and both sides are compared with significant difference（P=0.001）.
Chinese medicine side and blank side scalp fat secretion, the comparison of percutaneous loss of moist rate
Note：1. before experiment（0w）Compare no difference of science of statistics in both sides（P ＞ 0.05）
2. compared with same time blank group, P ＜ 0.05.
Embodiment 2
In the present embodiment, the anti-dandruff nourishing essence dew of plant is extracted by water, ethanol, butanediol, glycerine, glycine betaine, radix sophorae
Thing, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, tetrahydrochysene are recklessly
Green pepper alkali, Sodium Hyaluronate, xanthans, Phenoxyethanol and Sensiva SC50 composition.
The specific anti-dandruff nourishing essence dew product form of plant is as shown in table 2.
Table 2.
The preparation method following steps of the anti-dandruff nourishing essence dew of plant（Fig. 1）：
1）1 to No. 12 raw material is weighed by the formula shown in table 2, it is standby.
2）According to the Feedstock Component content shown in 1 and No. 2 in table 2, open and stir simultaneously to addition water, ethanol in tank is made
Mix, be well mixed, it is standby.
3）According to the Feedstock Component content in table 2 shown in 8,5 and No. 9, under agitation one by one to make added in tank panthenol,
Glycine betaine, dipotassium glycyrrhizinate, stir transparent to solution, produce mixed solution a.
4）To making to add in tank uniform fourth is pre-mixed according to the Feedstock Component content in table 2 shown in 3,10 and No. 12
Glycol, tetrahydrochysene pipering, Sodium Hyaluronate mixed solution.Stirring 30 minutes, produces mixed solution b.
5）To making to add in tank uniform xanthan is pre-mixed according to the Feedstock Component content shown in 11 and No. 4 in table 2
Glue and glycerine mixed solution.Stirring 30 minutes, produces mixed solution c.
6）Extracted according to the Feedstock Component content shown in No. 6 in table 2 to addition kuh-seng root extract, the root bark of shaggy-fruited dittany in tank is made
Thing, Angelica roots, radix stemonae sessilifoliae root powder and cnidium monnieri berry extract.Stirring 10 minutes, produces mixed solution d.
7）According to the Feedstock Component content shown in No. 7 in table 2 preservative Phenoxyethanol and ethyl hexyl are added into making tank
Base glycerol.Stirring 10 minutes, produce the anti-dandruff nourishing essence dew semi-finished product of plant.
8）Filling, packaging after the anti-dandruff nourishing essence dew semi-finished product detection of plant is qualified, product inspection warehousing after passing, is produced
The anti-dandruff nourishing essence dew finished product of plant.
The application method and compliance test result of the anti-dandruff nourishing essence dew of plant：
【Application method】After hair washing, take appropriate this product to be uniformly applied to scalp, and suitably massage to promote to absorb.
【Points for attention】Avoid it is pleasing to the eye, if pleasing to the eye please being rinsed immediately with water accidentally；Shady place is positioned over, avoids children from grabbing
Take；Allergic constitution person uses with caution.
【Compliance test result】
1 materials and methods
1.1 main agents and instrument：Without the neutral shampoo of anti-dandruff and nourishing effect (the limited public affairs of ZHANGGUANG 101 science and technology share
Department provides）, the anti-dandruff scalp protective agent of Chinese medicine, SEBUMETER SM810 measuring instruments, Tewameter testers.
1.2 research object：Severe dandruff patient in 30, wherein male 6, women 24, average age 23.26 ±
3.02 year.
1.2.1 inclusion criteria：Total score is counted at 25 points according to international " ten grades of point systems of tackness dandruff " dandruff
Dandruff subject above.
1.1.2 exclusion standard：Meet above-mentioned inclusion criteria but merge other skin diseases, or system use in 2 weeks is anti-before Chinese medicine
The antipruritics such as histamine drug, glucocorticoid, antiandrogen preparation, estrogen, immunomodulator, antidepression class medicine and antimycotic
Class medicine history, or scalp external application glucocorticoid, cutin cracking-off agent, immunomodulator, antimycotic medicine and other treatment of dandruff
With the externally applied drug person of seborrhea;Used during Chinese medicine using other shampoos, hair conditioner, pour mask, treatment wax persons, or hair
The Hair Stying Products persons such as hair-dryer, straight panel folder;To testing with neutral shampoo allergy sufferers;Not strictly in accordance with experimental program person.
1.3 research contents
1.3.1 the phase is eluted：All subjects for intending participating in Chinese medicine unify neutrality of the use research offer without anti-dandruff component
Shampoo one week, have one's hair wash 1 time within average 1-3 days, have one's hair wash 1 time within 24 hours before experiment, it is desirable to which subject is in whole research cycle
Hair cleaning is carried out using the shampoo.
1.3.2 research method
1.3.2.1 blind is set and random coded processing:Using randomized double-blind blank research, third party will according to random table
Research object head on both sides（Using forehead hairline median line as boundary）It is divided into Chinese medicine side and blank side（Placebo）, and research is protected
Shield agent only marks subject's coding and left and right sides with protective agent with blank, gives researcher.
1.3.2.2 application method：It is required that subject is daily according to the bottled outer left and right sides for compiling note of protective agent by two kinds of scalps
Protective agent is uniformly applied to scalp left and right sides respectively, and once a day, service life is 4 weeks.
1.3.2.3 efficacy assessments：After the elution end of term, Chinese medicine 2 weeks, after 4 weeks, follow-up period carry out 4 evaluation and tests, evaluate and test content
Including symptom scores, skin barrier function determines two parts.
1.3.3 research contents
1.3.3.1 symptom scores
Scalp is divided into 6 regions（Left and right sides difference Qu E Ding Zhensange areas）, according to international " tackness head
Ten grades of point system notes of bits calculate dandruff score summation in selected viewing area.Dandruff standards of grading：0 point indicates no dandruff, 1-2
Be divided into the greyish white rough scales of small flakes, 3-4 points are as low as median size chip, 5-6 points be with loose be connected big of scalp and
Thin chip, 7-8 points are big tackness chip, and 9-10 points are the white thicker scales of skin that peel off to yellow with scalp close attachment.
With the forehead hairline median line point left and right sides, using subject's self-assessment method, self-appraisal content includes scalp oil
Greasy degree, itching of the scalp degree, the itching of the scalp frequency.
1.3.3.2 skin barrier function determines
It is required that 20 DEG C of laboratory temperature, air humidity 40%, subject is not engaged in strenuous exercise before functional examination in 1h,
Without dominant perspiration, and the 20min that sits quietly.
Measurement site takes at 4 points：With the forehead hairline median line point left and right sides, apart from scalp center line both sides about 3cm, apart from head
Skin anterior hair line 3cm chooses at 2 points, and horizontal scalp center line of boss parietal or so 3cm chooses at 2 points, and each measurement point is tested 3 times and taken repeatedly
Average value, forehead and top statistical average is taken to represent scalp barrier function average level.
Scalp fat secretion is determined using Sebumeter SM810 measuring instruments, Tewameter testers determine percutaneous moisture
Loss Rate.
1.3.3.3 safety evaluatio：According to《Cosmetics health specification》Normal individual trial Chinese medicine skin adverse reaction classification mark
Standard, respectively at mid-term on probation（2w）, try out latter stage（4w）, follow-up period monitoring product whether there is excitant.
1.3.4 data analysis
Data analysis is carried out using spss17.0 software kits, clinical efficacy scoring uses rank test, uses and match somebody with somebody between two groups
T is examined, with P<0.05 is significance test standard.
2 results
2.1 subject's ordinary circumstances：30 subjects are fully completed this research, have no adverse reaction, test preceding both sides and face
Bed evaluation and scalp barrier function have comparativity through statistical calculations no significant difference（P ＞ 0.05）.
Chinese medicine side and the comparison of blank side symptom scores（x±s）
Note：1. before experiment（0w）Compare no difference of science of statistics in both sides（P ＞ 0.05）,
2.Compared with same time blank side, both sides are compared with significant difference（P ＜ 0.05）.
2.2 Chinese medicine sides and the comparison of blank side symptom scores
Chinese medicine side is compared with blank side, Chinese medicine side research latter stage（4w）Dandruff total score is less than blank side, has conspicuousness
Difference（Z=- 2.265, P=0.024）, both sides itching of the scalp degree, the itch frequency, the greasy degree of scalp has no notable difference（P>
0.05）（Table 1）.
2.3 Chinese medicine sides and blank side scalp fat secretion, the comparison of percutaneous loss of moist rate
Latter stage is studied compared with blank side in Chinese medicine side（4w）, follow-up period（5w）Chinese medicine side fat secretion amount is reduced, and has system
Meter learns difference（P=0.006, P=0.004）.Study latter stage（4w）Both sides loss of moist rate has no notable difference, after disabling 1w, with
The visit phase（5w）Chinese medicine side loss of moist rate is less than blank side, and both sides are compared with significant difference（P=0.001）.
Chinese medicine side and blank side scalp fat secretion, the comparison of percutaneous loss of moist rate
Note：1. before experiment（0w）Compare no difference of science of statistics in both sides（P ＞ 0.05）
2. compared with same time blank group, P ＜ 0.05.
Embodiment 3
In the present embodiment, the anti-dandruff nourishing essence dew of plant is extracted by water, ethanol, butanediol, glycerine, glycine betaine, radix sophorae
Thing, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae root powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, tetrahydrochysene are recklessly
Green pepper alkali, Sodium Hyaluronate, xanthans, Phenoxyethanol and Sensiva SC50 composition.
The specific anti-dandruff nourishing essence dew product form of plant is as shown in table 3.
Table 3.
The preparation method following steps of the anti-dandruff nourishing essence dew of plant（Fig. 1）：
1）1 to No. 12 raw material is weighed by the formula shown in table 3, it is standby.
2）According to the Feedstock Component content shown in 1 and No. 2 in table 3, open and stir simultaneously to addition water, ethanol in tank is made
Mix, be well mixed, it is standby.
3）According to the Feedstock Component content in table 3 shown in 8,5 and No. 9, under agitation one by one to make added in tank panthenol,
Glycine betaine, dipotassium glycyrrhizinate, stir transparent to solution, produce mixed solution a.
4）To making to add in tank uniform fourth is pre-mixed according to the Feedstock Component content in table 3 shown in 3,10 and No. 12
Glycol, tetrahydrochysene pipering, Sodium Hyaluronate mixed solution.Stirring 30 minutes, produces mixed solution b.
5）To making to add in tank uniform xanthan is pre-mixed according to the Feedstock Component content shown in 11 and No. 4 in table 3
Glue and glycerine mixed solution.Stirring 30 minutes, produces mixed solution c.
6）Extracted according to the Feedstock Component content shown in No. 6 in table 3 to addition kuh-seng root extract, the root bark of shaggy-fruited dittany in tank is made
Thing, Angelica roots, radix stemonae sessilifoliae root powder and cnidium monnieri berry extract.Stirring 10 minutes, produces mixed solution d.
7）According to the Feedstock Component content shown in No. 7 in table 3 preservative Phenoxyethanol and ethyl hexyl are added into making tank
Base glycerol.Stirring 10 minutes, produce the anti-dandruff nourishing essence dew semi-finished product of plant.
8）Filling, packaging after the anti-dandruff nourishing essence dew semi-finished product detection of plant is qualified, product inspection warehousing after passing, is produced
The anti-dandruff nourishing essence dew finished product of plant.
The application method and compliance test result of the anti-dandruff nourishing essence dew of plant：
【Application method】After hair washing, take appropriate this product to be uniformly applied to scalp, and suitably massage to promote to absorb.
【Points for attention】Avoid it is pleasing to the eye, if pleasing to the eye please being rinsed immediately with water accidentally；Shady place is positioned over, avoids children from grabbing
Take；Allergic constitution person uses with caution.
【Compliance test result】
1 materials and methods
1.1 main agents and instrument：Without the neutral shampoo of anti-dandruff and nourishing effect (the limited public affairs of ZHANGGUANG 101 science and technology share
Department provides）, the anti-dandruff scalp protective agent of Chinese medicine, SEBUMETER SM810 measuring instruments, Tewameter testers.
1.2 research object：Severe dandruff patient in 30, wherein male 5, women 25, average age 21.66 ±
2.87 year.
1.2.1 inclusion criteria：Total score is counted at 25 points according to international " ten grades of point systems of tackness dandruff " dandruff
Dandruff subject above.
1.1.2 exclusion standard：Meet above-mentioned inclusion criteria but merge other skin diseases, or system use in 2 weeks is anti-before Chinese medicine
The antipruritics such as histamine drug, glucocorticoid, antiandrogen preparation, estrogen, immunomodulator, antidepression class medicine and antimycotic
Class medicine history, or scalp external application glucocorticoid, cutin cracking-off agent, immunomodulator, antimycotic medicine and other treatment of dandruff
With the externally applied drug person of seborrhea;Used during Chinese medicine using other shampoos, hair conditioner, pour mask, treatment wax persons, or hair
The Hair Stying Products persons such as hair-dryer, straight panel folder;To testing with neutral shampoo allergy sufferers;Not strictly in accordance with experimental program person.
1.3 research contents
1.3.1 the phase is eluted：All subjects for intending participating in Chinese medicine unify neutrality of the use research offer without anti-dandruff component
Shampoo one week, have one's hair wash 1 time within average 1-3 days, have one's hair wash 1 time within 24 hours before experiment, it is desirable to which subject is in whole research cycle
Hair cleaning is carried out using the shampoo.
1.3.2 research method
1.3.2.1 blind is set and random coded processing:Using randomized double-blind blank research, third party will according to random table
Research object head on both sides（Using forehead hairline median line as boundary）It is divided into Chinese medicine side and blank side（Placebo）, and research is protected
Shield agent only marks subject's coding and left and right sides with protective agent with blank, gives researcher.
1.3.2.2 application method：It is required that subject is daily according to the bottled outer left and right sides for compiling note of protective agent by two kinds of scalps
Protective agent is uniformly applied to scalp left and right sides respectively, and once a day, service life is 4 weeks.
1.3.2.3 efficacy assessments：After the elution end of term, Chinese medicine 2 weeks, after 4 weeks, follow-up period carry out 4 evaluation and tests, evaluate and test content
Including symptom scores, skin barrier function determines two parts.
1.3.3 research contents
1.3.3.1 symptom scores
Scalp is divided into 6 regions（Left and right sides difference Qu E Ding Zhensange areas）, according to international " tackness head
Ten grades of point system notes of bits calculate dandruff score summation in selected viewing area.Dandruff standards of grading：0 point indicates no dandruff, 1-2
Be divided into the greyish white rough scales of small flakes, 3-4 points are as low as median size chip, 5-6 points be with loose be connected big of scalp and
Thin chip, 7-8 points are big tackness chip, and 9-10 points are the white thicker scales of skin that peel off to yellow with scalp close attachment.
With the forehead hairline median line point left and right sides, using subject's self-assessment method, self-appraisal content includes scalp oil
Greasy degree, itching of the scalp degree, the itching of the scalp frequency.
1.3.3.2 skin barrier function determines
It is required that 20 DEG C of laboratory temperature, air humidity 40%, subject is not engaged in strenuous exercise before functional examination in 1h,
Without dominant perspiration, and the 20min that sits quietly.
Measurement site takes at 4 points：With the forehead hairline median line point left and right sides, apart from scalp center line both sides about 3cm, apart from head
Skin anterior hair line 3cm chooses at 2 points, and horizontal scalp center line of boss parietal or so 3cm chooses at 2 points, and each measurement point is tested 3 times and taken repeatedly
Average value, forehead and top statistical average is taken to represent scalp barrier function average level.
Scalp fat secretion is determined using Sebumeter SM810 measuring instruments, Tewameter testers determine percutaneous moisture
Loss Rate.
1.3.3.3 safety evaluatio：According to《Cosmetics health specification》Normal individual trial Chinese medicine skin adverse reaction classification mark
Standard, respectively at mid-term on probation（2w）, try out latter stage（4w）, follow-up period monitoring product whether there is excitant.
1.3.4 data analysis
Data analysis is carried out using spss17.0 software kits, clinical efficacy scoring uses rank test, uses and match somebody with somebody between two groups
T is examined, with P<0.05 is significance test standard.
2 results
2.1 subject's ordinary circumstances：30 subjects are fully completed this research, have no adverse reaction, test preceding both sides and face
Bed evaluation and scalp barrier function have comparativity through statistical calculations no significant difference（P ＞ 0.05）.
Chinese medicine side and the comparison of blank side symptom scores（x±s）
Note：1. before experiment（0w）Compare no difference of science of statistics in both sides（P ＞ 0.05）,
2.Compared with same time blank side, both sides are compared with significant difference（P ＜ 0.05）.
2.2 Chinese medicine sides and the comparison of blank side symptom scores
Chinese medicine side is compared with blank side, Chinese medicine side research latter stage（4w）Dandruff total score is less than blank side, has conspicuousness
Difference（Z=- 2.265, P=0.024）, both sides itching of the scalp degree, the itch frequency, the greasy degree of scalp has no notable difference（P>
0.05）（Table 1）.
2.3 Chinese medicine sides and blank side scalp fat secretion, the comparison of percutaneous loss of moist rate
Latter stage is studied compared with blank side in Chinese medicine side（4w）, follow-up period（5w）Chinese medicine side fat secretion amount is reduced, and has system
Meter learns difference（P=0.006, P=0.004）.Study latter stage（4w）Both sides loss of moist rate has no notable difference, after disabling 1w, with
The visit phase（5w）Chinese medicine side loss of moist rate is less than blank side, and both sides are compared with significant difference（P=0.001）.
Chinese medicine side and blank side scalp fat secretion, the comparison of percutaneous loss of moist rate
Note：1. before experiment（0w）Compare no difference of science of statistics in both sides（P ＞ 0.05）
2. compared with same time blank group, P ＜ 0.05.
Claims (7)
- A kind of 1. anti-dandruff nourishing essence dew of plant, by water, ethanol, butanediol, glycerine, glycine betaine, kuh-seng root extract, the root bark of shaggy-fruited dittany It is extract, Angelica roots, radix stemonae sessilifoliae root powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, tetrahydrochysene pipering, transparent Matter acid sodium, xanthans, Phenoxyethanol and Sensiva SC50 composition,Wherein, the weight/mass percentage composition of the ethanol is 10-50%, and the weight/mass percentage composition of the water is 24.125- 84.825%, the butanediol weight/mass percentage composition is 2-10%, and the weight/mass percentage composition of the glycerine is 1-5%, the sweet tea The weight/mass percentage composition of dish alkali is 1-5%, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae Total percentage composition of root powder and cnidium monnieri berry extract is 0.5-2.5%, and the weight/mass percentage composition of the panthenol is 0.2-1%, institute The weight/mass percentage composition for stating dipotassium glycyrrhizinate is 0.2-1%, and the weight/mass percentage composition of the tetrahydrochysene pipering is 0.05- 0.25%, the weight/mass percentage composition of the Sodium Hyaluronate is 0.005-0.025%, and the weight/mass percentage composition of the xanthans is 0.02-0.1%, the Phenoxyethanol, the weight/mass percentage composition of Sensiva SC50 are 0.2-1%.
- 2. the anti-dandruff nourishing essence dew of plant according to claim 1, it is characterised in that the weight/mass percentage composition of the ethanol For 32%, the weight/mass percentage composition of the water is 52.83%, and the butanediol weight/mass percentage composition is 5%, the matter of the glycerine It is 3.5% to measure percentage composition, and the weight/mass percentage composition of the glycine betaine is 3%, the kuh-seng root extract, root bark of shaggy-fruited dittany extraction Thing, Angelica roots, total percentage composition of radix stemonae sessilifoliae root powder and cnidium monnieri berry extract are 2%, the quality hundred of the panthenol It is 0.5% to divide content, and the weight/mass percentage composition of the dipotassium glycyrrhizinate is 0.5%, and the quality percentage of the tetrahydrochysene pipering contains Measure as 0.1%, the weight/mass percentage composition of the Sodium Hyaluronate is 0.01%, and the weight/mass percentage composition of the xanthans is 0.06%, the weight/mass percentage composition of the Phenoxyethanol and Sensiva SC50 is 0.5%.
- 3. the anti-dandruff nourishing essence dew of plant according to claim 1 or 2, it is characterised in that the kuh-seng root extract, white Fresh hide extract, Angelica roots, the mass ratio of radix stemonae sessilifoliae root powder and cnidium monnieri berry extract are 25%：20%：20%： 20%：15%.
- 4. a kind of preparation method of the anti-dandruff nourishing essence dew of plant, comprises the following steps：Water, ethanol, butanediol, glycerine, glycine betaine, kuh-seng root extract, Cortex Dictamni extract, Angelica roots, upright hundred Portion's root powder, cnidium monnieri berry extract, panthenol, dipotassium glycyrrhizinate, tetrahydrochysene pipering, Sodium Hyaluronate, xanthans, Phenoxyethanol and second Base hexyl glycerine is well mixed to obtain the anti-dandruff nourishing essence dew of plant,Wherein, the weight/mass percentage composition of the ethanol is 10-50%, and the weight/mass percentage composition of the water is 24.125- 84.825%, the butanediol weight/mass percentage composition is 2-10%, and the weight/mass percentage composition of the glycerine is 1-5%, the sweet tea The weight/mass percentage composition of dish alkali is 1-5%, the kuh-seng root extract, Cortex Dictamni extract, Angelica roots, radix stemonae sessilifoliae Total percentage composition of root powder and cnidium monnieri berry extract is 0.5-2.5%, and the weight/mass percentage composition of the panthenol is 0.2-1%, institute The weight/mass percentage composition for stating dipotassium glycyrrhizinate is 0.2-1%, and the weight/mass percentage composition of the tetrahydrochysene pipering is 0.05- 0.25%, the weight/mass percentage composition of the Sodium Hyaluronate is 0.005-0.025%, and the weight/mass percentage composition of the xanthans is 0.02-0.1%, the Phenoxyethanol, the weight/mass percentage composition of Sensiva SC50 are 0.2-1%.
- 5. according to the method for claim 4, it is characterised in that the weight/mass percentage composition of the ethanol is 32%, the water Weight/mass percentage composition be 52.83%, the butanediol weight/mass percentage composition is 5%, and the weight/mass percentage composition of the glycerine is 3.5%, the weight/mass percentage composition of the glycine betaine is 3%, the kuh-seng root extract, Cortex Dictamni extract, angelica root extraction Total percentage composition of thing, radix stemonae sessilifoliae root powder and cnidium monnieri berry extract is 2%, and the weight/mass percentage composition of the panthenol is 0.5%, The weight/mass percentage composition of the dipotassium glycyrrhizinate is 0.5%, and the weight/mass percentage composition of the tetrahydrochysene pipering is 0.1%, described The weight/mass percentage composition of Sodium Hyaluronate is 0.01%, and the weight/mass percentage composition of the xanthans is 0.06%, the benzene oxygen second The weight/mass percentage composition of alcohol and Sensiva SC50 is 0.5%.
- 6. according to the method for claim 5, it is characterised in that the preparation method of the anti-dandruff nourishing essence dew of plant includes Following steps：1) to making addition water and ethanol in tank while opening stirring, it is well mixed, it is standby；2) continue to add panthenol, glycine betaine and dipotassium glycyrrhizinate in tank to making one by one under agitation, stir it is transparent to solution, i.e., Obtain mixed solution a；3) continuously added into making in-tank mixing solution a and be pre-mixed uniform butanediol, tetrahydrochysene pipering, Sodium Hyaluronate Mixed solution；Stirring 30 minutes, produces mixed solution b；4) added into making in-tank mixing solution b and be pre-mixed uniform xanthans and glycerine mixed solution, stirred 30 minutes, Produce mixed solution c；5) kuh-seng root extract, Cortex Dictamni extract, Angelica roots, upright hundred are added into making in-tank mixing solution c Portion's root powder and cnidium monnieri berry extract, stir 10 minutes, produce mixed solution d；6) to addition preservative Phenoxyethanol and Sensiva SC50 in tank is made, stir 10 minutes, produce the anti-dandruff nourishing of plant Elite is revealed.
- 7. according to the method any one of claim 4-6, it is characterised in that the kuh-seng root extract, the root bark of shaggy-fruited dittany carry The mass ratio for taking thing, Angelica roots, radix stemonae sessilifoliae root powder and cnidium monnieri berry extract is 25%：20%：20%：20%： 15%.
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| CN105963165A (en) * | 2016-04-08 | 2016-09-28 | 东莞市长欣家化有限公司 | Shampoo prepared from wheat germ |
| CN107998046B (en) * | 2017-12-23 | 2019-11-05 | 江南大学 | A kind of scalp care compositions and preparation method thereof |
| CN108553382B (en) * | 2018-06-04 | 2020-06-23 | 纳爱斯集团有限公司 | Scalp care solution, scalp care composition and application thereof |
| CN110934783B (en) * | 2018-09-21 | 2022-06-28 | 珠海伊斯佳科技股份有限公司 | Dandruff-removing and itching-relieving composition containing Chinese herbal medicines, silicone oil-free amino acid shampoo containing composition, and preparation method and application of silicone oil-free amino acid shampoo |
| CN115245476A (en) * | 2022-06-16 | 2022-10-28 | 上海松皓生物科技有限公司 | Composition for removing dandruff, relieving itching and improving scalp microenvironment and preparation method thereof |
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| CN102580054A (en) * | 2012-02-24 | 2012-07-18 | 北京章光101科技股份有限公司 | Female scalp soothing hair-care shampoo and preparation method thereof |
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| CN102580054A (en) * | 2012-02-24 | 2012-07-18 | 北京章光101科技股份有限公司 | Female scalp soothing hair-care shampoo and preparation method thereof |
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