CN101502480A - Chinese herbal medicine composition with bacteriostatic, anti-dandruff and itching-relieving efficacies - Google Patents

Abstract

The invention discloses a Chinese traditional medicine composition having bacteriostatic, anti-dandruff and anti-itch functions. The active ingredients and weight percents of the composition are as follows: 1-50% of fructus cnidii, 1-60% of lightyellow sophora root, 0.5-40% of radix stemonae and 0.5-40% of densefruit pittany root-bark. Through conventional processes, the composition of the invention can be prepared into several kinds of hair cleanness and care products, such as liquid shampoos, cream shampoos or hair conditioners, etc. The composition of the invention is characterized in that natural and safe Chinese traditional medicines are used as main raw materials; reasonable processing technic is adopted; various ingredients are reasonably combined to reach the synergetic effect and are blended internally and externally via various ways to achieve the bacteriostatic, anti-dandruff and anti-itch effects.

Description

A Chinese herbal medicine composition with antibacterial, anti-dandruff and anti-itch effects

technical field

The present invention relates to a Chinese herbal medicine composition with antibacterial, antidandruff and antipruritic effects prepared with natural Chinese herbal medicines as main raw materials, in particular to a hair antibacterial, antidandruff and antipruritic effect prepared with natural Chinese herbal medicines as main raw materials Cleaning, care products such as shampoo, shampoo or conditioner etc.

Background technique

With the improvement of living standards and the popularization of health awareness, the shampooing frequency of Chinese urban residents is getting closer and closer to the level of developed countries, reaching 3 to 3.5 times per week. But to really be in line with the correct and healthy concept of life, blindly increasing the number of shampoos is far from enough. What we need to understand is how to scientifically wash and care for hair. In the environment we currently live in, pollution has reached an unprecedented level with the development of industrialization. Dust, ultraviolet rays, chemicals and various microorganisms (bacteria, mold/yeast) invade our hair all the time, causing various hair problems , such as dandruff, itchy scalp, split ends, dry hair, etc.

Dandruff is one of the main problems that plague modern people's hair. The main factors that dandruff produces are abnormal metabolism of the head and the reproduction and growth of Pityrosporum (Malassezia). According to a study by the Scalp Health Research Center of the China Health Education Association, 59% of female consumers and 63% of Chinese adults Male consumers have been plagued by dandruff. Simply shampooing with ordinary shampoo can at best clean the dirt and temporarily remove the dandruff on the surface of the hair, but it cannot really solve the dandruff problem fundamentally and meet the nutritional repair needs of the hair itself.

Contents of the invention

The object of the present invention is to provide a Chinese herbal medicine composition with antibacterial, anti-dandruff and antipruritic effects prepared from natural Chinese herbal medicines. Antibacterial, anti-dandruff and anti-itch effect.

The Chinese herbal medicine composition provided by the present invention has antibacterial, dandruff-relieving and antipruritic effects, and its active components and their proportions by weight are:

Fructus Cnidii 1-50, Sophora flavescens 1-60, Cnidaria 0.5-40, Radix Cortex 0.5-40.

The preferred proportioning by weight of the active components of the Chinese herbal medicine composition of the present invention is:

Fructus Cnidii 10-30, Sophora flavescens 20-50, Centipeda 5-25, and Fresh Peel 5-25.

The optimal weight ratio of the active components of the Chinese herbal medicine composition of the present invention is:

Fructus Cnidii 25, Sophora flavescens 35, Baibu 20, and Fresh Skin 20.

The above-mentioned Chinese herbal medicine composition with antibacterial, antidandruff and antipruritic effects can be made into various types of hair cleaning and care products, such as shampoo, shampoo or conditioner, etc. through conventional techniques.

Fructus Cnidii main functional ingredient is osthole, hard in nature, warm; It has the effect of expelling wind and relieving itching, drying dampness, and killing insects ("Preparation for the Nature of Herbal Medicine"), and can be used for applying sores to relieve itching, washing leprosy (treatment Scalp eczema), antibacterial and anti-inflammatory, regulate scalp keratinocyte metabolism. According to the in vitro antibacterial test, the osthole extract has a strong inhibitory effect on Malassezia (M.furfur) that induces dandruff.

The main functional ingredients of Sophora flavescens are matrine, oxymatrine, bitter and cold in nature; it has the effect of clearing away heat and dampness, and killing insects. It is suitable for dandruff, itchy scalp, eczema, eczema, scabies, leprosy and other symptoms. Mainly follow the "external cause" approach to achieve the effect of sterilization, antipruritic and anti-dandruff.

Baibu contains various active ingredients such as alkaloids, polysaccharides, proteins, malic acid, etc., which have the effects of warming lung qi, relieving cough, and killing insects. It mainly follows the "internal cause" approach to expelling wind and dampness, cooling blood stasis effect.

Cortex dictamni contains active ingredients such as leuconine, leucinactone, sitosterol, choline, etc. It has the functions of clearing away heat and dampness, expelling wind, and detoxifying. It is suitable for symptoms such as damp-heat sores and skin itching. Reach the effect of expelling wind and dampness, clearing heat and detoxifying.

The Chinese herbal medicine composition of the invention is characterized by taking natural Chinese herbal medicine as the main raw material, utilizing various components to rationally combine and synergize, and to achieve the effects of inhibiting bacteria, removing dandruff and relieving itching through various ways. The composition can be widely used in products such as shampoos, shampoos, and conditioners through conventional processing techniques, and can effectively inhibit the generation of dandruff and relieve symptoms such as itchy scalp and dry hair. The composition effectively combines traditional Chinese medicine theory with modern medical research results, and at the same time follows the principles of "internal cause" and "external cause" to achieve both internal and external effects, and provides a reference for comprehensively and thoroughly solving the problems of dandruff and itching. way.

Description of drawings

Fig. 1 is the objective image analysis figure of product effect experiment of the present invention;

Fig. 2 is the subjective evaluation data figure of product effect experiment of the present invention.

The present invention will be further described below through specific implementation methods and product effect research results.

Detailed ways

Some specific examples are listed below to illustrate the present invention. It should be pointed out that the following specific examples are only used to further illustrate the present invention, and do not represent limitations to the protection scope of the present invention. Some non-essential modifications and adjustments made by others according to the present invention still belong to the protection scope of the present invention.

Example 1

A Chinese herbal medicinal composition with antibacterial, dandruff-relieving and antipruritic effects, the active components and their weight ratios are: 25 parts of Cnidium chinensis, 35 parts of Sophora flavescens, 20 parts of Radix chinensis, and 20 parts of Radix Cortex.

Example 2

A Chinese herbal medicine composition with antibacterial, dandruff-relieving and antipruritic effects, the active components and their proportions by weight are: 15 parts of Cnidium Fructus Cnidii, 40 parts of Sophora Sophora, 25 parts of Herba Centifolia, and 20 parts of Cortex Dictatus.

Example 3

A Chinese herbal medicine composition with antibacterial, dandruff-relieving and antipruritic effects, the active components and their proportions by weight are as follows: 10 Cnidium Fructus Cnidii Fructus, 50 Sophora Sophorae, 30 Centipeda radix, and 10 Radix Cortex.

Example 4

A Chinese herbal medicinal composition with antibacterial, dandruff-relieving and antipruritic effects, the active components and their proportions by weight are as follows: 20 Cnidium Fructus Cnidii, 30 Sophora Sophora, 15 Centipeda and 35 Radix Cortex.

Example 5

A Chinese herbal medicine composition with antibacterial, dandruff-relieving and antipruritic effects, the active components and their proportions by weight are: 30 parts of Cnidium Fructus Cnidii, 35 parts of Sophora Sophora, 20 parts of Herba Centifolia, and 15 parts of Cortex Dictatus.

The Chinese herbal medicine composition described in the above examples can be formulated into various hair cleaning and care products, such as shampoo, shampoo or hair conditioner, etc. through conventional techniques.

Antibacterial effect research

According to the shampoo product that above-mentioned embodiment 1 makes, composition addition is 0.20% (w/w), and numbering is NF, and the applicant has carried out the bacteriostasis test to hair (skin) easy breeding, infection bacterium and fungus, The test results are as follows:

1. Test sample

A total of 4 shampoos, numbered as follows:

NF, KB, ZY (Phytoya): Provided by Southern Lee Kum Kee Co., Ltd.; BW: Well-known Chinese herbal medicine concept anti-dandruff shampoo on the market, (KB is a blank shampoo that does not add Chinese herbal medicine composition, and the rest of the ingredients are exactly the same as NF) .

2. Test indicators

Diameter of inhibition zone (mm); minimum inhibitory concentration (MIC, %)

3. Test results

3.1 Broad-spectrum antibacterial test results

Note: ^* D is the sum of the diameters of the inhibition zone for the three tested strains, the concentration of the bacteria solution is about 5.0×10 ⁷ cfu/ml, and the concentration of the mold and yeast solution is about 3.5×10 ⁶ cfu/ml.

According to the test data, except KB, the other three shampoos are more sensitive to the tested strains (D>27.0), among which NF has the best antibacterial effect.

3.2 Antibacterial test results of characteristic bacteria

sample name Test strain Minimum Inhibitory Concentration (MIC) NF Malassezia (ATCC 14521) 0.10% KB Malassezia (ATCC 14521) >0.50% ZY Malassezia (ATCC 14521) 0.30% BW Malassezia (ATCC 14521) 0.15%

Note: The action concentration of Malassezia bacteria solution is about 4.0×10 ⁵ cfu/ml.

According to the test data, the four shampoos have certain inhibitory effects on the tested strains, and the antibacterial effect of NF is better than that of ZY and BW.

Human Efficacy Research

According to the shampoo sample NF prepared in the above-mentioned Example 1, the applicant has carried out a human body anti-dandruff efficacy verification test, and the test results are as follows:

1. Experimental materials

1.1 Test sample

A total of 2 shampoos, numbered NF and BW (same as above).

1.2 Test object

The inclusion criteria were: non-pathological dandruff phenomenon of moderate or higher degree, and the degree of dandruff infection on the left and right sides was roughly the same.

1.3 Number of people tested

A total of 26 volunteers were selected for the experiment and divided into 2 groups. The actual number of participants was 20, including 10 males and 10 females, aged 20 to 50 years.

2. Experimental Design and Methods

2.1 Objective image analysis

According to the standard operating procedure, comb the dandruff on the left and right sides to the glass plate, then cover it with another glass plate of the same size, seal it and save it. Image analysis of glass plates was performed within 14 days.

Under the illumination condition of cold light source, a monochrome CCD camera was used to collect and save images of the glass plate against a black background. The pictures were analyzed by analysis software, and the area percentage (%) of dandruff was calculated.

2.2 Subjective evaluation of dandruff volume

The technicians scored the amount of dandruff on the left and right sides respectively according to the scoring criteria:

0...no dandruff; 1...scattered dandruff; 2...a little dandruff; 3...moderate dandruff; 4...a lot of dandruff.

2.3 Product Adaptability Evaluation

The technicians and the volunteers themselves evaluated the adaptability of the product on the left and right sides respectively. The adaptability evaluation parameters included scalp redness, scalp itching and burning sensation. The technicians evaluated the scalp redness; scalp itching and burning sensation were evaluated by Volunteers themselves conduct the evaluation.

Rating criteria for scalp redness, scalp itching, and burning sensation:

0…none; 1…slight; 2…moderate; 3…serious; 4…very serious.

3. Experimental results

3.1 Objective image analysis

As shown in Figure 1, from the image analysis data as a whole, the amount of dandruff in the BW group and the NF group basically decreased with the increase of the use time. The amount of dandruff in the NF group showed a significant decrease compared with the early use (t0) in the later period of product use (t5); the amount of dandruff in the BW group showed a downward trend, but there was no significant difference.

3.2 Subjective evaluation

As shown in Figure 2, from the perspective of subjective data as a whole, the amount of dandruff in the BW group and the NF group basically decreased with the increase of the use time. Compared with the early period (t0) of product use (t5), the amount of dandruff in the two test groups showed a significant reduction.

3.3 Product Adaptability Evaluation

Table 1.Result of the feeling itching of scalp

For scalp itching, scalp redness and burning sensation, both NF and BW showed a certain degree of relief (t4 compared with t0).

4. Summary

After using Shampoo NF for one month, through objective analysis and subjective evaluation, the amount of dandruff showed a decreasing trend, and it also relieved scalp itching, scalp redness and burning sensation to a certain extent.

Claims (4)

1. one kind has herbal composite antibacterial, anti-dandruff and itching-relieving efficacies, it is characterized in that the active component of said composition and weight portion proportioning thereof are: Fructus Cnidii 1～50, Radix Sophorae Flavescentis 1～60, the Radix Stemonae 0.5～40, Cortex Dictamni 0.5～40.

2. according to claim 1 have a herbal composite antibacterial, anti-dandruff and itching-relieving efficacies, and wherein the weight portion proportioning of each active component is: Fructus Cnidii 10～30, Radix Sophorae Flavescentis 20～50, the Radix Stemonae 5～25, Cortex Dictamni 5～25.

3. according to claim 1 have a herbal composite antibacterial, anti-dandruff and itching-relieving efficacies, and wherein the weight portion proportioning of each active component is: Fructus Cnidii 25, Radix Sophorae Flavescentis 35, the Radix Stemonae 20, Cortex Dictamni 20.

4. describedly have a herbal composite antibacterial, anti-dandruff and itching-relieving efficacies according to claim 1,2 or 3, it is characterized in that described herbal composite is shampoo, hair cream or hair conditioner.

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