CN102258727B

CN102258727B - External medicament for treating equine seborrheic dermatitis and preparation method thereof

Info

Publication number: CN102258727B
Application number: CN 201110198342
Authority: CN
Inventors: 王开; 温伟
Original assignee: Jilin Agricultural University
Current assignee: Jilin Agricultural University
Priority date: 2011-07-07
Filing date: 2011-07-07
Publication date: 2013-01-30
Anticipated expiration: 2031-07-07
Also published as: CN102258727A

Abstract

The invention discloses an external medicament for treating equine seborrheic dermatitis and a preparation method thereof. The medicament consists of the following components in parts by weight and alcohol: 45-55 parts of root bark of shaggy-fruited dittany, 40-50 parts of spreading hedyotis herb, 45-55 parts of lightyellow sophora root, 25-35 parts of cocklebur fruit, 25-35 parts of sessile stemona root, 40-50 parts of wild chrysanthemum, 25-35 parts of common cnidium fruit, 25-35 parts of broom cypress fruit, 20-35 parts of oriental arborvitae, 25-35 parts of fructus forsythiae, 25-35 partsof root bark of the peony tree, 105-189 parts of salicylic acid powder and 21-27 parts of sulfanilamide powder. In the medicament, the effects of clearing heat, dispelling wind and relieving itching of the formula are enhanced through organic combination, dialectical compatibility and mutual assistance, so that the aim of curing the equine seborrheic dermatitis is fulfilled. The external medicament has the advantages of low cost, easiness in preparation, no toxic or side effect and obvious therapeutic effect. Clinical practice proves that the cure rate of the medicament is 96.7 percent and the effectiveness ratio is 100 percent.

Description

A kind of equine dermatitis external used medicine and preparation method thereof for the treatment of

Technical field:

The present invention relates to a kind of equine dermatitis external used medicine and preparation method thereof for the treatment of.

Background technology:

The seborrheic dermatitis of equus is comparatively common clinically, multiplely is born in the saddle-riding horse, particularly is easy to the horses of seborrhea after driving, and sweating is too much, and fur loses again in scrubbing, and easily suffers from this disease.Cause that this sick reason is comparatively complicated, it is generally acknowledged relevant with the chronic stimulation of seborrhea, antibacterial infection, endocrine and digestive system, neural functional disorder and contactant.During morbidity, suffer from horse before this at the back, particularly the general term for saddle and stirrups bottom secondly at buttocks, then at shank, is developed at last abdominal part so that large-area dermatosis occurred to whole body.Performance skin is contaminated, is covered with the mixture of more greasy scales, dust and perspiration, by a hair bonding cluster, after 3-4 days, by a hair fall in flakes, skin have ooze out on a small quantity after, tie yellow crust, this disappears, and that is long, delay is repeatedly.Suffer from the horse pruritus, constantly rub the stake of tree sassafras, the horses skin that has is rubbed.Though through conscientiously cleaning, occur again in a few days.Primary disease is thought by veterinary of motherland is that strongly fragrant then blood is dry for a long time because heresy of wind heat is outer attacks, and blood deficiency is living wind then, and the wind-dryness pathogenic heat is accumulate the resistance skin, skin lose moisten foster so that pachylosis, drying; Or because feeding and management is improper, and the concentrate of feeding is too much, so that the intestines and stomach dysfunction of the spleen in transportation and transformation, give birth to humidogene heat, the damp-heat accumulation skin forms.To suffering from horse scraping affected part squama, disconnected hair or crust through microscopy, do not find vermin and fungal infection.At present, although it is a lot of to treat the medicine of equine dermatitis both at home and abroad, mostly be greatly Western medicine, have that toxic and side effects is large, a drug residue, contaminated environment, and the shortcoming such as treatment cost is high, effect is not ideal enough.

Summary of the invention:

The object of the invention is to overcome the at present weak point on treatment equine dermatitis, the external used medicine of the higher treatment equine dermatitis of a kind of easy, easy to prepare and cheap curative effect of drawing materials is provided.

A kind of equine dermatitis external used medicine for the treatment of, it is comprised of following weight parts:

Cortex Dictamni 45-55 part, Herba Hedyotidis Diffusae 40-50 part, Radix Sophorae Flavescentis 45-55 part, Fructus Xanthii 25-35 part, Radix Stemonae 25-35 part, Herba Dendranthematis indici 40-50 part, Fructus Cnidii 25-35 part, Fructus Kochiae 25-35 part, Cacumen Platycladi 20-35 part, Fructus Forsythiae 25-35 part, Cortex Moutan 25-35 part, salicylic acid powder 105-189 part, sulfa powder 21-27 part, ethanol 1400-1800 part;

Be preferably: 50 parts of Cortex Dictamni, 45 parts of Herba Hedyotidis Diffusaes, 50 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Xanthii, 30 parts of the Radixs Stemonae, 45 parts in Herba Dendranthematis indici, 30 parts of Fructus Cnidiis, 30 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 30 parts of Fructus Forsythiaes, 30 parts of Cortex Moutans, 144 parts of salicylic acid powder, 24 parts of sulfa powders;

Described alcohol concentration is 70-75%.

A kind of preparation method for the treatment of equine dermatitis external used medicine, it comprises:

1) Chinese medicine is pulverized after, 50-90 ℃ water logging 2-6 hour, filter;

2) get filtering residue, use again alcohol-pickled 72 hours, filter;

3) with step 1) filtrate, with step 2) filtrate merges, and reenters to add salicylic acid powder and sulfa powder, transferring to alcohol content is 70-75%, Chinese medicine content is 2-3g/ml.

A kind of another embodiment for the treatment of the preparation method of equine dermatitis external used medicine is:

With the alcohol-pickled Chinese medicine of 50-65%, get filtrate, behind adding salicylic acid and the sulfa powder, transferring to alcohol content with 90%-100% ethanol again is 70-75%;

Preferred 60% alcohol-pickled Chinese medicine.

A kind of equine dermatitis external used medicine for the treatment of provided by the invention, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Kochiae heat clearing and damp drying in the side, dispelling wind for relieving itching has preferably curative effect to skin pruritus; Herba Dendranthematis indici, Herba Hedyotidis Diffusae, Fructus Forsythiae, Cortex Moutan heat-clearing and toxic substances removing; The dehumidifying of Fructus Xanthii powder wind, the kind rubella pruritus of controlling; Fructus Cnidii the kidney warming, dampness, dispel the wind; The Radix Stemonae has after the effect of good killing parasites for relieving itching, particularly steeping in wine, better effects if; The Cacumen Platycladi cooling blood for hemostasis can promote the growth of fur; Salicylic acid has the ability of good exfoliation, unclogging, and is safe in finite concentration, and less to the zest of skin; Sulfa powder has good antibacterial action to skin.

All medicines share the agent that becomes altogether clearing away heat and expelling wind antipruritic.

The side's of system characteristics: our with heat clearing and damp drying, the detoxifcation of dispeling the wind, the antipruritic and usefulness of grease removal holds concurrently to promote hair growth, prevent courses of infection, treating both the principal and secondary aspects of a disease.

Said medicine is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country has strengthened the antipruritic effect of the party's clearing away heat and expelling wind, thereby reached the purpose of curing the equine dermatitis.The external used medicine that adopts preparation method of the present invention to make has that cost is low, preparation easily, have no side effect and evident in efficacy.Clinical practice proves, the cure rate 96.7% of this medicine, effective percentage 100%.

The specific embodiment

1 one kinds of treatments of embodiment equine dermatitis external used medicine

Composition by weight: 55 parts of Cortex Dictamni, 50 parts of Herba Hedyotidis Diffusaes, 55 parts of Radix Sophorae Flavescentiss, 35 parts of Fructus Xanthii, 35 parts of the Radixs Stemonae, 50 parts in Herba Dendranthematis indici, 35 parts of Fructus Cnidiis, 35 parts of the Fructus Kochiae, 35 parts of Cacumen Platycladis, 35 parts of Fructus Forsythiaes, 35 parts of Cortex Moutans, 189 parts of salicylic acid powder, 27 parts of sulfa powders; 1800 parts of ethanol.Described alcohol concentration is 70-75%.

2 one kinds of treatments of embodiment equine dermatitis external used medicine

Composition by weight: 45 parts of Cortex Dictamni, 40 parts of Herba Hedyotidis Diffusaes, 45 parts of Radix Sophorae Flavescentiss, 25 parts of Fructus Xanthii, 25 parts of the Radixs Stemonae, 40 parts in Herba Dendranthematis indici, 25 parts of Fructus Cnidiis, 25 parts of the Fructus Kochiae, 25 parts of Cacumen Platycladis, 25 parts of Fructus Forsythiaes, 25 parts of Cortex Moutans, 105 parts of salicylic acid powder, 21 parts of sulfa powders, 1400 parts of ethanol.Described alcohol concentration is 70-75%.

3 one kinds of external used medicines for the treatment of the equine dermatitis of embodiment

Composition by weight: 50 parts of Cortex Dictamni, 45 parts of Herba Hedyotidis Diffusaes, 50 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Xanthii, 30 parts of the Radixs Stemonae, 45 parts in Herba Dendranthematis indici, 30 parts of Fructus Cnidiis, 30 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 30 parts of Fructus Forsythiaes, 30 parts of Cortex Moutans, 144 parts of salicylic acid powder, 24 parts of sulfa powders, 1400 parts of ethanol.Described alcohol concentration is 70-75%.4 one kinds of preparation methoies for the treatment of equine dermatitis external used medicine of embodiment

1) embodiment 1,2 or 3 Chinese medicine are pulverized after, 50-90 hot water soaked 2-6 hour, filtered;

2) get filtering residue, use again 90% alcohol-pickled 72 hours, filter;

Embodiment 5

Weigh by embodiment 1,2 or 3 proportionings, wherein Chinese medicine powder is broken into coarse powder after, adopt the mode of cold-maceration.First the medical material of pulverizing is put into macerator and add 60% ethanol, be respectively 900 parts, 700 parts or 800 parts, build lid, flooded 72 hours, in dipping process, often jolting or stirring is to accelerate leaching.Then take out impregnation liquid, filter, and the squeezing medicinal residues, with pressed liquor and the leachate merging of gained.Medicinal residues are put into macerator again, add again 60% ethanol, be respectively 450 parts, 350 parts, 400 parts dippings 72 hours; Again squeeze medicinal residues, with pressed liquor and the leachate merging of gained; Twice soak mixed, again filter, then add 900 parts of 90% ethanol, 700 parts, 800 parts, so that the impregnation liquid alcohol concentration is about 75%.The contained Chinese medicine crude drug of medicinal liquid through the said method preparation is respectively 0.2528g/ml, 0.2529g/ml, 0.25g/ml.Soak is added respectively 189 parts of salicylic acid powder, 105 parts, 144 parts, add 27 parts, 21 parts, 24 parts of sulfa powders, constantly stir in the process that adds, it is fully dissolved, both must treat the external used medicine liniment of equine dermatitis.

Experimental example

Using method: 1. before the medication, will suffer from first the horse whole body and conscientiously scrub, words with good conditionsi, available shampoo of dispelling oils and fats is scrubbed.Remove quilt hair, greasy scales and other dirts of bonding cluster.

2. scrubbed Ma Tihou, after by the moisture drying of hair,, examine with tweezers folder cotton balls embrocate at the skin affected part of horse, the place of omission has not been arranged.

3. respectively embrocate once morning and afternoon every day, five days is a course for the treatment of.Have pair horse to realize really at every turn before embrocating and scrub, in therapeutic process, the phenomenon that the top layer scurf comes off can appear in pars affecta skin, scurf must be cleaned out again embrocate, in order to avoid medicinal liquid does not reach skin.

Criterion of therapeutical effect: the seborrheic dermatitis of the external medication horse for the treatment of equine dermatitis, whether the symptom of efficacy determination Main Basis equine dermatitis disappears.Taking medicine 5 days is a course for the treatment of, and concrete curative effect is divided into three grades:

Cure: the seborrheic dermatitis symptom of horse all disappears;

Take a turn for the better: the seborrheic dermatitis symptom of horse partly disappears;

Invalid: the seborrheic dermatitis symptom of horse is without obvious improvement.

I am between more than ten years of 1995-2007, and seborrheic dermatitis 36 examples for the treatment of altogether various horses in certain Derby, certain vehicle and horse guard of honour are treated a course for the treatment of, wherein cure 34 examples, 2 examples that take a turn for the better, cure rate 94.44%, effective percentage 100%.

Claims

1. treat equine dermatitis external used medicine for one kind, it is comprised of the following raw material medicaments weight portion: Cortex Dictamni 45-55 part, Herba Hedyotidis Diffusae 40-50 part, Radix Sophorae Flavescentis 45-55 part, Fructus Xanthii 25-35 part, Radix Stemonae 25-35 part, Herba Dendranthematis indici 40-50 part, Fructus Cnidii 25-35 part, Fructus Kochiae 25-35 part, Cacumen Platycladi 20-35 part, Fructus Forsythiae 25-35 part, Cortex Moutan 25-35 part, salicylic acid powder 105-189 part, sulfa powder 21-27 part, ethanol 1400-1800 part.

2. a kind of equine dermatitis external used medicine for the treatment of according to claim 1 is characterized in that it is comprised of the following raw material medicaments weight portion:

50 parts of Cortex Dictamni, 45 parts of Herba Hedyotidis Diffusaes, 50 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Xanthii, 30 parts of the Radixs Stemonae, 45 parts in Herba Dendranthematis indici, 30 parts of Fructus Cnidiis, 30 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 30 parts of Fructus Forsythiaes, 30 parts of Cortex Moutans, 144 parts of salicylic acid powder, 24 parts of sulfa powders.

3. a kind of equine dermatitis external used medicine for the treatment of according to claim 1 and 2 is characterized in that alcohol concentration is 70-75%.

4. preparation method for the treatment of equine dermatitis external used medicine, it comprises:

1) Cortex Dictamni 45-55 part, Herba Hedyotidis Diffusae 40-50 part, Radix Sophorae Flavescentis 45-55 part, Fructus Xanthii 25-35 part, Radix Stemonae 25-35 part, Herba Dendranthematis indici 40-50 part, Fructus Cnidii 25-35 part, Fructus Kochiae 25-35 part, Cacumen Platycladi 20-35 part, Fructus Forsythiae 25-35 part, Cortex Moutan 25-35 part, salicylic acid powder 105-189 part, sulfa powder 21-27 part, ethanol 1400-1800 part, after the Chinese medicine pulverizing, 50-90 ℃ of hot water soaked 2-6 hour, filtered;

2) get filtering residue, use again alcohol-pickledly, filter;

3) with the filtrate of step 1), with step 2) filtrate merges, and adds salicylic acid powder and sulfa powder again, and rectification essence to content is 70-75%, and Chinese medicine content is 2-3 g/ml.

5. preparation method for the treatment of equine dermatitis external used medicine is characterized in that: with the alcohol-pickled Chinese medicine of 50-65%, get filtrate, add salicylic acid and sulfa powder after, transferring to alcohol content with 90%-100% ethanol again is 70-75%.

6. a kind of preparation method for the treatment of equine dermatitis external used medicine according to claim 7 is characterized in that: with 60% alcohol-pickled Chinese medicine.