CN102258727A

CN102258727A - External medicament for treating equine seborrheic dermatitis and preparation method thereof

Info

Publication number: CN102258727A
Application number: CN2011101983425A
Authority: CN
Inventors: 温伟
Original assignee: Jilin Agricultural University
Current assignee: Jilin Agricultural University
Priority date: 2011-07-07
Filing date: 2011-07-07
Publication date: 2011-11-30
Anticipated expiration: 2031-07-07
Also published as: CN102258727B

Abstract

The invention discloses an external medicament for treating equine seborrheic dermatitis and a preparation method thereof. The medicament consists of the following components in parts by weight and alcohol: 45-55 parts of root bark of shaggy-fruited dittany, 40-50 parts of spreading hedyotis herb, 45-55 parts of lightyellow sophora root, 25-35 parts of cocklebur fruit, 25-35 parts of sessile stemona root, 40-50 parts of wild chrysanthemum, 25-35 parts of common cnidium fruit, 25-35 parts of broom cypress fruit, 20-35 parts of oriental arborvitae, 25-35 parts of fructus forsythiae, 25-35 parts of root bark of the peony tree, 105-189 parts of salicylic acid powder and 21-27 parts of sulfanilamide powder. In the medicament, the effects of clearing heat, dispelling wind and relieving itching of the formula are enhanced through organic combination, dialectical compatibility and mutual assistance, so that the aim of curing the equine seborrheic dermatitis is fulfilled. The external medicament has the advantages of low cost, easiness in preparation, no toxic or side effect and obvious therapeutic effect. Clinical practice proves that the cure rate of the medicament is 96.7 percent and the effectiveness ratio is 100 percent.

Description

Excessive dermatitis external used medicine of a kind of treatment horse fat and preparation method thereof

Technical field:

The present invention relates to excessive dermatitis external used medicine of a kind of treatment horse fat and preparation method thereof.

Background technology:

The seborrheic dermatitis of equus is comparatively common clinically, and pilosity is born in the saddle-riding horse, and the horses that particularly are easy to seborrhea are after driving, and sweating is too much, and fur loses again in scrubbing, and easily suffers from this disease.Cause that this sick reason is comparatively complicated, it is generally acknowledged relevant with the chronic stimulation of seborrhea, bacterial infection, endocrine and digestive system, neural functional disorder and contactant.During morbidity, suffer from horse before this at the back, particularly the general term for saddle and stirrups bottom secondly at buttocks, then at shank, is developed into abdominal part at last so that large-area dermatosis occurred to whole body.Performance skin is contaminated, is covered with the mixture of more greasy scales, dust and perspiration, by a hair bonding cluster, after 3-4 days, by a hair fall in flakes, skin have ooze out on a small quantity after, tie yellow crust, this disappears, and that is long, delay is repeatedly.Suffer from the horse pruritus, constantly rub the stake of tree sassafras, the horses skin that has is rubbed.Though, occur again in a few days through conscientiously cleaning.Primary disease is thought by veterinary of motherland is that strongly fragrant then blood is dry for a long time because heresy of wind heat is outer attacks, the then living wind of blood deficiency, the wind-dryness pathogenic heat is accumulate the resistance skin, skin lose moisten foster so that pachylosis, drying; Or, give birth to humidogene heat because feeding and management is improper, and the concentrate of feeding is too much, so that the intestines and stomach dysfunction of the spleen in transportation and transformation, the damp-heat accumulation skin forms.Scrape and get affected part squama, disconnected hair or crust suffering from horse, do not find vermin and fungal infection through microscopy.At present,, mostly be Western medicine greatly, have that toxic and side effects is big, a drug residue, contaminated environment though it is a lot of to treat the overflow medicine of dermatitis of horse fat both at home and abroad, and shortcoming such as treatment cost height, effect be not ideal enough.

Summary of the invention:

The objective of the invention is to overcome the weak point on the treatment horse fat overflows dermatitis at present, the external used medicine that provides the higher treatment horse fat of a kind of easy, easy to prepare and cheap curative effect of drawing materials to overflow dermatitis.

A kind of treatment horse fat dermatitis external used medicine that overflows, it is made up of following weight parts:

Cortex Dictamni 45-55 part, Herba Hedyotidis Diffusae 40-50 part, Radix Sophorae Flavescentis 45-55 part, Fructus Xanthii 25-35 part, Radix Stemonae 25-35 part, Herba Dendranthematis indici 40-50 part, Fructus Cnidii 25-35 part, Fructus Kochiae 25-35 part, Cacumen Platycladi 20-35 part, Fructus Forsythiae 25-35 part, Cortex Moutan 25-35 part, salicylic acid powder 105-189 part, sulfa powder 21-27 part, ethanol 1400-1800 part;

Be preferably: 50 parts of Cortex Dictamni, 45 parts of Herba Hedyotidis Diffusaes, 50 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Xanthii, 30 parts of the Radixs Stemonae, 45 parts in Herba Dendranthematis indici, 30 parts of Fructus Cnidiis, 30 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 30 parts of Fructus Forsythiaes, 30 parts of Cortex Moutans, 144 parts of salicylic acid powder, 24 parts of sulfa powders;

Described alcohol concentration is 70-75%.

A kind of preparation method for the treatment of the excessive dermatitis external used medicine of horse fat, it comprises:

1) Chinese medicine is pulverized after, 50-90 ℃ water logging 2-6 hour, filter;

2) get filtering residue, alcohol-pickled 72 hours of reuse filters;

3) with the filtrate of step 1), with step 2) filtrate merges, and reenters to add salicylic acid powder and sulfa powder, and transferring to alcohol content is 70-75%, and Chinese medicine content is 2-3g/ml.

A kind of another embodiment for the treatment of the preparation method of the excessive dermatitis external used medicine of horse fat is:

With the alcohol-pickled Chinese medicine of 50-65%, get filtrate, behind adding salicylic acid and the sulfa powder, it is 70-75% that reuse 90%-100% ethanol transfers to alcohol content;

Preferred 60% alcohol-pickled Chinese medicine.

A kind of treatment horse fat provided by the invention dermatitis external used medicine that overflows, Cortex Dictamni, Radix Sophorae Flavescentis, Fructus Kochiae heat clearing and damp drying in the side, dispelling wind for relieving itching has curative effect preferably to skin pruritus; Herba Dendranthematis indici, Herba Hedyotidis Diffusae, Fructus Forsythiae, Cortex Moutan heat-clearing and toxic substances removing; The dehumidifying of Fructus Xanthii powder wind, the kind rubella pruritus of controlling; Fructus Cnidii the kidney warming, dampness, dispel the wind; The Radix Stemonae has after the effect of good killing parasites for relieving itching, particularly steeping in wine, better effects if; The Cacumen Platycladi cooling blood for hemostasis can promote the growth of fur; Salicylic acid has the ability of good exfoliation, unclogging, and is safe in finite concentration, and less to the zest of skin; Sulfa powder has the excellent antibiotic effect to skin.

All medicines share the agent that becomes clearing away heat and expelling wind antipruritic altogether.

The side's of system characteristics: our with heat clearing and damp drying, the detoxifcation of dispeling the wind, the antipruritic and usefulness of grease removal is held concurrently to promote hair growth, to prevent courses of infection, treating both the principal and secondary aspects of a disease.

Said medicine is through organic assembling, dialectical compatibility and assisting a ruler in governing a country mutually, and having strengthened should side's clearing away heat and expelling wind itching relieving effect, cures the overflow purpose of dermatitis of horse fat thereby reach.The external used medicine that adopts preparation method of the present invention to make has that cost is low, preparation easily, have no side effect and evident in efficacy.Clinical practice proves, the cure rate 96.7% of this medicine, effective percentage 100%.

The specific embodiment

The excessive dermatitis external used medicine of 1 one kinds of treatments of embodiment horse fat

Composition by weight: 55 parts of Cortex Dictamni, 50 parts of Herba Hedyotidis Diffusaes, 55 parts of Radix Sophorae Flavescentiss, 35 parts of Fructus Xanthii, 35 parts of the Radixs Stemonae, 50 parts in Herba Dendranthematis indici, 35 parts of Fructus Cnidiis, 35 parts of the Fructus Kochiae, 35 parts of Cacumen Platycladis, 35 parts of Fructus Forsythiaes, 35 parts of Cortex Moutans, 189 parts of salicylic acid powder, 27 parts of sulfa powders; 1800 parts of ethanol.Described alcohol concentration is 70-75%.

The excessive dermatitis external used medicine of 2 one kinds of treatments of embodiment horse fat

Composition by weight: 45 parts of Cortex Dictamni, 40 parts of Herba Hedyotidis Diffusaes, 45 parts of Radix Sophorae Flavescentiss, 25 parts of Fructus Xanthii, 25 parts of the Radixs Stemonae, 40 parts in Herba Dendranthematis indici, 25 parts of Fructus Cnidiis, 25 parts of the Fructus Kochiae, 25 parts of Cacumen Platycladis, 25 parts of Fructus Forsythiaes, 25 parts of Cortex Moutans, 105 parts of salicylic acid powder, 21 parts of sulfa powders, 1400 parts of ethanol.Described alcohol concentration is 70-75%.

3 one kinds of external used medicines for the treatment of the excessive dermatitis of horse fat of embodiment

Composition by weight: 50 parts of Cortex Dictamni, 45 parts of Herba Hedyotidis Diffusaes, 50 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Xanthii, 30 parts of the Radixs Stemonae, 45 parts in Herba Dendranthematis indici, 30 parts of Fructus Cnidiis, 30 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 30 parts of Fructus Forsythiaes, 30 parts of Cortex Moutans, 144 parts of salicylic acid powder, 24 parts of sulfa powders, 1400 parts of ethanol.Described alcohol concentration is 70-75%.4 one kinds of preparation methoies for the treatment of the excessive dermatitis external used medicine of horse fat of embodiment

1) after the Chinese medicine pulverizing with embodiment 1,2 or 3,50-90 hot water soaked 2-6 hour, filtered;

2) get filtering residue, reuse 90% alcohol-pickled 72 hours filters;

Embodiment 5

Weigh by embodiment 1,2 or 3 proportionings, wherein Chinese medicine powder is broken into coarse powder after, adopt the mode of cold-maceration.Earlier the medical material of pulverizing is put into macerator and add 60% ethanol, be respectively 900 parts, 700 parts or 800 parts, build lid, flooded 72 hours, in dipping process, often jolting or stirring is to accelerate leaching.Take out impregnation liquid then, filter, and the squeezing medicinal residues, with the pressed liquor and the leachate merging of gained.Medicinal residues are put into macerator again, add 60% ethanol again, be respectively 450 parts, 350 parts, 400 parts dippings 72 hours; Squeeze medicinal residues once more, with the pressed liquor and the leachate merging of gained; Twice soak mixed, filter once more, add 900 parts of 90% ethanol, 700 parts, 800 parts then, make that the impregnation liquid alcohol concentration is about 75%.Be respectively 0.2528g/ml, 0.2529g/ml, 0.25g/ml through the contained Chinese medicine crude drug of the medicinal liquid of method for preparing.Soak is added 189 parts of salicylic acid powder, 105 parts, 144 parts respectively, add 27 parts, 21 parts, 24 parts of sulfa powders, constantly stir in the process that adds, it is fully dissolved, both must treat the overflow external used medicine liniment of dermatitis of horse fat.

Experimental example

Using method: 1. before the medication, will suffer from the horse whole body earlier and conscientiously scrub, words with good conditionsi are availablely dispeled greasy shampoo and are scrubbed.Remove quilt hair, greasy scales and other dirts of bonding cluster.

2. scrubbed Ma Tihou, treated, with tweezers folder cotton balls embrocate, examine, the place of omission has not been arranged at the skin affected part of horse by behind the moisture drying of hair.

3. respectively embrocate once morning and afternoon every day, five days is a course of treatment.All have pair horse to realize really at every turn before embrocating and scrub, in therapeutic process, the phenomenon that the top layer scurf comes off can appear in pars affecta skin, scurf must be cleaned out embrocate again, in order to avoid medicinal liquid does not reach skin.

Criterion of therapeutical effect: the seborrheic dermatitis of the external medication horse of the excessive dermatitis of treatment horse fat, whether efficacy determination mainly disappears according to the symptom of the excessive dermatitis of horse fat.Taking medicine 5 days is a course of treatment, and concrete curative effect is divided into three grades:

Cure: the seborrheic dermatitis symptom of horse all disappears;

Take a turn for the better: the seborrheic dermatitis symptom of horse partly disappears;

Invalid: the seborrheic dermatitis symptom of horse does not have obvious improvement.

I 1995-2007 ten surplus in the period of, seborrheic dermatitis 36 examples for the treatment of various horses altogether in certain Derby, certain vehicle and horse guard of honour are treated a course of treatment, wherein cure 34 examples, 2 examples that take a turn for the better, cure rate 94.44%, effective percentage 100%.

Claims

1. treat the excessive dermatitis external used medicine of horse fat for one kind, it is made up of following weight parts: Cortex Dictamni 45-55 part, Herba Hedyotidis Diffusae 40-50 part, Radix Sophorae Flavescentis 45-55 part, Fructus Xanthii 25-35 part, Radix Stemonae 25-35 part, Herba Dendranthematis indici 40-50 part, Fructus Cnidii 25-35 part, Fructus Kochiae 25-35 part, Cacumen Platycladi 20-35 part, Fructus Forsythiae 25-35 part, Cortex Moutan 25-35 part, salicylic acid powder 105-189 part, sulfa powder 21-27 part, ethanol 1400-1800 part.

2. a kind of treatment horse fat according to claim 1 dermatitis external used medicine that overflows is characterized in that it is made up of following weight parts:

50 parts of Cortex Dictamni, 45 parts of Herba Hedyotidis Diffusaes, 50 parts of Radix Sophorae Flavescentiss, 30 parts of Fructus Xanthii, 30 parts of the Radixs Stemonae, 45 parts in Herba Dendranthematis indici, 30 parts of Fructus Cnidiis, 30 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 30 parts of Fructus Forsythiaes, 30 parts of Cortex Moutans, 144 parts of salicylic acid powder, 24 parts of sulfa powders.

3. a kind of treatment horse fat according to claim 1 and 2 dermatitis external used medicine that overflows is characterized in that alcohol concentration is 70-75%.

4. treat the overflow preparation method of dermatitis external used medicine of horse fat for one kind, it comprises:

1) with after the Chinese medicine pulverizing, 50-90 ℃ of hot water soaked 2-6 hour, filtered;

2) get filtering residue, reuse is alcohol-pickled, filters;

3) with the filtrate of step 1), with step 2) filtrate merges, and adds salicylic acid powder and sulfa powder again, and rectification essence to content is 70-75%, and Chinese medicine content is 2-3g/ml.

5. treat the overflow preparation method of dermatitis external used medicine of horse fat for one kind, it is characterized in that: with the alcohol-pickled Chinese medicine of 50-65%, get filtrate, add salicylic acid and sulfa powder after, it is 70-75% that reuse 90%-100% ethanol transfers to alcohol content.

6. a kind of preparation method for the treatment of the excessive dermatitis external used medicine of horse fat according to claim 7 is characterized in that: with 60% alcohol-pickled Chinese medicine.