CN101766697A - Antifungal medicament for treating skin tinea and preparation method thereof - Google Patents

Abstract

The invention discloses an antifungal medicament for treating skin tinea and a preparation method thereof. The medicament mainly comprises sweet wormwood volatile oil, divaricatus and rhubarb as raw materials to prepare effective components, and a pharmaceutically acceptable vector is added to prepare the medicament for external use. The medicament and the manufacturing method of the invention are unique, have a wide antifungal spectrum, obtain good curative effects for treating tinea capitis, tinea corporis, tinea cruris, tinea manuum, tinea pedis, tinea unguium and senile pruritus through clinical experiments, and have no toxic side effects on a human body and viscera.

Description

Medicine of a kind of antifungal therapy skin tinea and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, relate in particular to a kind of preparation method of medicine and this medicine of antifungal therapy skin tinea.

Background technology

Mycosis is skin frequently-occurring disease, common clinical, the pathogenic bacterium strains that go down to posterity that belong to more, medicine is easily produced drug resistance, because the transformation gene that goes down to posterity, a lot of medicines are through continuing or reuse after a while, mostly produce drug resistance, for example clotrimazole is controlled and is read strain bacterium property paronychia.Case: curative effect was fine in first two months, repeated to use to 3 months then to lose efficacy.Control as fluconazol and to read strain bacterium property paronychia case, took medicine 3 months, every day consumption 150mg, the basic healing is anti-recurrence, continues medication, 1 150mg clothes is to 9 months weekly, accumulative total continuous use totally a year, 12 finger (toe) still all recur.The ointment of present commercially available treatment dermatomycosis, tincture, water preparation have produced drug resistance mostly, and effect is not as good as time spent even inefficacy just.Therefore people's Chinese medicine and ancient prescription of seeking motherland's medical science is used for treating dermatomycosis tinea disease.It is mostly effective that the ancient prescription proved recipe is put washout outward on the skin, but use trouble, the part that still has some deficits, so draw former worthies' experience, by a large amount of clinical practices, coupling Chinese and western medicine knowledge is made the prescription rule at the rational matter of mycosis: 1, the effect of solution pervasion skin keratin is arranged; 2, drug effect can be oozed and be reached the focus sterilization; 3, the pharmacological action of powerful long-acting broad-spectrum antibacterial is arranged; 4, the compound recipe combined and alternatively uses multiple drug effect to prolong antibiotic effective acting time, and anti-drug resistance also strengthens antimicrobial effect; 5, strengthen the skin protection function to consolidate antibiotic dealing with problems arising from an accident.Select the medicine prescription according to above-mentioned rule, Clinical Practice is used for the treatment of tinea capitis, tinea corporis, tinea cruris, tinea manus and pedis, tinea unguium and moistens, and the itching skin disease of profit fungus invasion is lost in the effect of skin protection control fungus to middle-aged and elderly people autumn and winter skin, obtain good efficacy, and have no side effect.

Summary of the invention

One of purpose of the present invention provides a kind of medicine of antifungal therapy skin tinea, and this medicine can effectively improve mycotic cure rate, and has no side effect.

Another object of the present invention provides the preparation method of this medicine.

Solution of the present invention is based on: the inventor thinks that through clinical practice for many years and experimental study the tinea disease is to be produced toxin and fallen ill by the Dermallly affixed human body Intradermal that parasitizes of pathogenic fungus, the strains that go down to posterity that belong to more, change gene and drug resistance by going down to posterity, so found: can the solution pervasion skin keratin, thoroughly reach focus, powerful long-acting broad-spectrum antibacterial, multiple drug effect is pulled together antibiotic and the drug-fast treatment rule that prevents to go down to posterity, and forms effective prescription under the guidance of this treatment rule.

The present invention seeks to realize by following scheme:

The medicine of antifungal therapy skin tinea provided by the invention, it is the topical agent of making by effective ingredient and pharmaceutically acceptable carrier, in per 100 milliliters topical agent, effective ingredient mainly is to be made by following raw material by weight ratio: Herba Artemisiae Annuae volatile oil 4～18g, Radix Strophanthi Divaricati 20～50g, Radix Et Rhizoma Rhei 10～40g.

Medicine of the present invention is a principal agent with Herba Artemisiae Annuae volatile oil and Radix Strophanthi Divaricati broad-spectrum antifungal, Herba Artemisiae Annuae volatile oil gets the Radix Strophanthi Divaricati help, can prolong antibiotic effect duration, be aided with the anti-10 kinds of funguses of Radix Et Rhizoma Rhei, Radix Strophanthi Divaricati is joined Radix Et Rhizoma Rhei two medicine functions and is filled a vacancy expansion antimicrobial spectrum, the strong brave violent property of Radix Et Rhizoma Rhei inhibition Radix Strophanthi Divaricati mutually, eliminate its side effect, form strong effect wide-spectrum treatment tinea disease prescription altogether.

Thicker at tinea disease position skin keratin, active ingredient raw materials also further select for use the medicine of antibiotic dissolving cutin and preferably amount ranges be: salicylic acid 3～10g, benzoic acid 0.2～0.3g; Carrier is selected 95% concentration ethanol solution and glycerol for use, and the amount ranges of glycerol is 5～15g.Prepare per 100 milliliters of topical agents, wherein the optimum amount of each active ingredient raw materials is: Herba Artemisiae Annuae volatile oil 8g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 30g, salicylic acid 8g, benzoic acid 0.3g; In the carrier, the consumption of glycerol is 6g.

At the fungi conditioned pathogen, active ingredient raw materials also further add the skin protection antibacterials and preferably amount ranges be: Pericarpium Zanthoxyli volatile oil 3～9g, Oleum Verniciae fordii (or Oleum Camelliae) 30～40g, carrier is selected horse hair oil for use.Prepare 100 milliliters of topical agents, wherein the optimum amount of each active ingredient raw materials is: Herba Artemisiae Annuae volatile oil 12g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 20g, Pericarpium Zanthoxyli volatile oil 6g, Oleum Verniciae fordii (or Oleum Camelliae) 38g.

Going down to posterity at fungus changes the gene drug resistance, active ingredient raw materials also further add medicine and preferably amount ranges be: Pericarpium Zanthoxyli volatile oil 3～6g, salicylic acid 3～8g, benzoic acid 0.2～0.3g; Carrier is selected 95% concentration ethanol solution for use.Prepare 100 milliliters of topical agents, wherein each active ingredient raw materials optimised quantity is: Herba Artemisiae Annuae volatile oil 12g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 20g, Pericarpium Zanthoxyli volatile oil 6g, salicylic acid 6g, benzoic acid 0.2g.

At middle-aged and elderly people autumn and winter skin pruritus, active ingredient raw materials also further add the antimicrobial medicine of skin moistening and preferably amount ranges be: Oleum Verniciae fordii 26～30g, Oleum Camelliae 26～40g; Described carrier is a horse hair oil.Prepare 100 milliliters of topical agents, wherein each active ingredient raw materials optimised quantity is: Herba Artemisiae Annuae volatile oil 4g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 30g, Oleum Verniciae fordii 25g, Oleum Camelliae 30g.

The preparation method of medicine of the present invention is as follows:

1) it is standby to take by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei according to effective raw material weight proportioning; 2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicine, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B; 3) Herba Artemisiae Annuae volatile oil and medicinal liquid A, B mix homogeneously are stirred the effective ingredient of cost medicine, make 100 milliliters of topical agents with pharmaceutically acceptable carrier again.

If also with salicylic acid, benzoic acid, glycerol, the combination of 95% concentration ethanol solution, the preparation method of medicine of the present invention is as follows:

1) takes by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, salicylic acid, benzoic acid, glycerol and 95% enough concentration ethanol solution for standby according to effective raw material weight proportioning; 2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B; 3) with salicylic acid and benzoic acid and glycerol part 95% concentration ethanol solution dissolving, add medicinal liquid A, B and Herba Artemisiae Annuae volatile oil again, after evenly stirring, add 95% concentration ethanol solution again and make 100 milliliters of topical agents through even the stirring.

If also close with Pericarpium Zanthoxyli volatile oil, Oleum Verniciae fordii or Oleum Camelliae, horse hair line of oils, the preparation method of medicine of the present invention is as follows:

1) according to effective raw material weight proportioning take by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, Pericarpium Zanthoxyli volatile oil, Oleum Verniciae fordii or Oleum Camelliae, horse hair oil is standby; 2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B; 3) with the effective ingredient of medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Pericarpium Zanthoxyli volatile oil, Oleum Verniciae fordii or Oleum Camelliae mix homogeneously stirring cost medicine, add horse hair oil again and make 100 milliliters of topical agents through evenly stirring.

If also with salicylic acid, benzoic acid, Pericarpium Zanthoxyli volatile oil, the combination of 95% concentration ethanol solution, the preparation method of medicine of the present invention is as follows:

1) takes by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, salicylic acid, benzoic acid, Pericarpium Zanthoxyli volatile oil and 95% enough concentration ethanol solution for standby according to the raw material weight proportioning; 2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B; 3) salicylic acid, benzoic acid and glycerol are used the dissolving of part 95% concentration ethanol solution, added medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Pericarpium Zanthoxyli volatile oil again, add 95% concentration ethanol solution again through even stirring and make 100 milliliters of topical agents through even the stirring.

If also close with Oleum Verniciae fordii, Oleum Camelliae, horse hair line of oils, the preparation method of medicine of the present invention is as follows:

1) take by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, Oleum Verniciae fordii, Oleum Camelliae according to the raw material weight proportioning and enough horse hair oil standby; 2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B; 3) behind the effective ingredient with medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Oleum Verniciae fordii or Oleum Camelliae mix homogeneously stirring cost medicine, add horse hair oil again and make 100 milliliters of topical agents through evenly stirring.

The used medicine material of the present invention all can be buied from Chinese medicine shop or pharmaceutical factory, and its specification meets national medical standard; Below the pharmacology and the function of each raw material is introduced:

Radix Strophanthi Divaricati:

This product is the dry product of apocynaceae plant Radix Strophanthi Divaricati stem and leaf, and bitter cold is poisonous, can separate sore, parasite killing is controlled scabies, and its water extracting alcohol hypostasis effective ingredient can kill various funguses and read the strain bacterium.This medicine can be made the vein cardiotonic, and a small amount of external is to the human body avirulence.Be stated from the 15th edition 337 pages of " new pharmacology " Chen Xinqian works.This medicine choosing is stated from " Chinese medicinal plants will " Yang Lunliang work " poison book on Chinese herbal medicine " the 951st page.

Consumption: think that through 10 years'experiences 15% is effectively antibacterial, 30% is effectively antibiotic, and 50% is potent antibiotic, can antimicrobial agent.

Radix Et Rhizoma Rhei:

This product is the dry root and rhizome of polygonum rheum palmatum, Tang Gushi Radix Et Rhizoma Rhei or Rheum officinale.The removing pathogenic heat from blood and toxic substance from the body relieving constipation, water extract-alcohol precipitation liquid can resist 10 kinds of funguses, and can remove Radix Strophanthi Divaricati to itching to the inflammation effect, and antibacterials such as the staphylococcus of inhibition, molten chain, golden Portugal are arranged.(be selected from " Chinese medicine application "＜1〉the 61st page.)

Herba Artemisiae Annuae volatile oil:

This product is tender stem, leaf and the seed of feverfew Herba Artemisiae Annuae, the volatile oil of extraction, and 1% concentration is to all tinea bacterium and read the strain bacterium bactericidal action is arranged, and antivirus action is arranged.(seeing " Chinese medicine modern study and clinical practice " 1 the 401st page for details).(in state-owned 4 large-scale pharmaceutical factories produce and sell, be to extract) with " super critical extraction "

Oleum Verniciae fordii:

The fruit that the tung tree autumn and winter gather is through squeezing the oils and fats of coming out, and for oral administration poisonous, the traditional Chinese medical science is often done external, is surgery medicine commonly used, detoxifcation doctor's skin ulcer antifungal and antibacterial, and parasite killing is controlled scabies, and oily skin moistening is prevented and treated fungus, relieving itching.(choosing is stated from Zhanjiang region Chinese herbal medicine handbook commonly used, and publish in April, 1970) market is on sale.

Horse hair oil:

Claim Oleum Terebinthinae again, this product is the oleoresin that oozes out in the some plants of Pinaceae Pinus, through distilling or extracting the volatile oil that obtains, the effect of infiltration chafe is arranged.See " Chinese medicine modern study and clinical practice "＜3 for details〉the 159th page.Woodsization factory is on sale.

Pericarpium Zanthoxyli:

This product is the dry mature skin of Folium Symplocoris Caudatae plant green pepper or Pericarpium Zanthoxyli, and killing parasites for relieving itching is controlled eczema, the pruritus scabies, and volatile oil can suppress 15 kinds of funguses.Use supercritical extraction, also available high alcohol leaching is extracted and the way of distillation is extracted.(seeing " Chinese medicine uses 3 " the 108th page for details)

Oleum Camelliae:

This product is the expressed oil of plant of theaceae seed of Japanese Camellia, and edible oil among the people has profit skin, parasite killing detoxifcation, controls scabies and skin pruritus effect.See " Chinese medicine application "＜3〉the 198th page for details.

Salicylic acid:

" Chinese pharmacopoeia records antifungal, antipruritic, dissolving effect such as cutin (" new pharmacology " is also on the books).Usual amounts 3～10%.

Benzoic acid:

" Chinese pharmacopoeia records antifungic action, joins salicylic acid and controls scytitis, usual amounts 0.2～0.3%.(" new pharmacology " is also on the books))

Glycerol:

" Chinese pharmacopoeia records profit skin, antiinflammation, and the hydrotropy salicylic acid.(" new pharmacology " is also on the books)

The specific embodiment

Embodiment one

(1) take by weighing Herba Artemisiae Annuae volatile oil 18g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 30g is standby;

(2) with the effective ingredient of raw material Radix Strophanthi Divaricati with " decoction and alcohol sedimentation technique " extraction Radix Strophanthi Divaricati, be specially: pot is put in Radix Strophanthi Divaricati chopping decocted with water twice and (soak afterwards earlier and fry in shallow oil, soaked summer 3 hours, soaked winter 4 hours), adding for the first time 6 times of amounts of water (water and raw material weight ratio) fries in shallow oil, filter medicinal liquid A1, adding for the second time 5 times of amounts of water (water and raw material weight ratio) fries in shallow oil again, filter medicinal liquid A2, fry in shallow oil all is to fry in shallow oil out with high heat earlier at every turn, the reuse filtration of removing slag after four hours at a simmer, merge medicinal liquid A1 and A2 and carry out 70～80 ℃ of low-temperature evaporations, being condensed into the raw material weight ratio is 1: 20～1: 30 thick paste, divide again add gradually 95% concentration ethanol solution stirring evenly to the heavy liquid concentration of ethanol be till 75%, leave standstill the heavy hypostasis that goes then, reclaim ethanol, so heavy twice, reclaiming ethanol again and being condensed into the raw material weight ratio is 0.95: 10 medicinal liquid 4.75g; Add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, the medicinal liquid A of 10g is standby.The extraction of effective components of Radix Et Rhizoma Rhei is identical with the Radix Strophanthi Divaricati extracting method, and the medical liquid B that gets 6g is standby; And dated content of dispersion is as effective ingredient (the preferably back of decolouring clarification earlier reconcentration).

(3) mix medicinal liquid A, B and the mixing of Herba Artemisiae Annuae volatile oil thoroughly make this medicine effective ingredient, add pharmaceutically acceptable carrier (for example glycerol or horse hair oil again, carrier also can be selected according to known technology or the used feedstock property of medicine of the present invention voluntarily by those skilled in the art) to 100 milliliters, make topical agent through stirring, dosage form can be oil preparation, the agent of water alcohol.

Certainly, be not limited to and make 100 milliliters topical agent, if make some more or less topical agent, the material quantity of effective ingredient and carrier just correspondingly increases or reduces.

Embodiment two

Take by weighing Herba Artemisiae Annuae volatile oil 4g, Radix Strophanthi Divaricati 40g, Radix Et Rhizoma Rhei 10g; Concrete manufacture method such as embodiment one.

Embodiment three

Take by weighing Herba Artemisiae Annuae volatile oil 4g, Radix Strophanthi Divaricati 20g, Radix Et Rhizoma Rhei 10g; Concrete manufacture method such as embodiment one.

Embodiment four

Take by weighing Herba Artemisiae Annuae volatile oil 18g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 40g; Concrete manufacture method such as embodiment one.

Embodiment five

(1) takes by weighing Herba Artemisiae Annuae volatile oil 8g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 30g, salicylic acid 8g, benzoic acid 0.3g, glycerol 6g and 95% enough concentration ethanol solution for standby;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei according to the extracting method of embodiment one respectively medicinal liquid A, B are standby;

(3) earlier salicylic acid, benzoic acid and glycerol are dissolved with part 95% concentration ethanol solution, add medicinal liquid A, B and Herba Artemisiae Annuae volatile oil again, add 95% concentration ethanol solution to 100 milliliter again through stirring, leaving standstill to sink in 7-15 days after stirring goes microgranule to make topical agent, this topical agent is the agent of high sour water alcohol, be primarily aimed at the thicker use of tinea manus and pedis disease position skin keratin, can be used for whole body tinea disease (reason be anti-salicylic acid consumption too much cause acid absorb and poison) on a small quantity.

Embodiment six

(1) it is standby to take by weighing Herba Artemisiae Annuae volatile oil 12g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 20g, Pericarpium Zanthoxyli volatile oil 6g, Oleum Verniciae fordii 38g (available Oleum Camelliae replacement) and the horse hair oil of capacity;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei according to the extracting method of embodiment one respectively medicinal liquid A, B are standby;

(3) medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Pericarpium Zanthoxyli volatile oil, Oleum Verniciae fordii mix homogeneously are stirred the effective ingredient of cost medicine after, add horse hair oil to 100 milliliter again, make topical agent through stirring, this topical agent is an oil preparation, is primarily aimed at the fungi conditioned pathogen; Major function is antibiotic and strengthens skin care function control fungus.Whole body tinea disease all is suitable for, and notes not using mucosa, wound, pudendum organ, than the careful usefulness of book skin (oxter, abdominal part ditch, pudendum).Write for the ease of following, claim that this topical agent is the wholesomeness oil preparation.

Certainly, in the present embodiment, Oleum Verniciae fordii can replace with the Oleum Camelliae of equivalent.

Embodiment seven

(1) takes by weighing 95% concentration ethanol solution for standby of Herba Artemisiae Annuae volatile oil 12g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 20g, Pericarpium Zanthoxyli volatile oil 6g, salicylic acid 6g, benzoic acid 0.2g and capacity;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei according to the extracting method of embodiment one respectively medicinal liquid A, B are standby;

(3) salicylic acid, benzoic acid and glycerol are dissolved with part 95% concentration ethanol solution, add medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Pericarpium Zanthoxyli volatile oil again, add 95% concentration ethanol solution to 100 milliliter again through stirring, leave standstill after making through stirring and heavyly went microgranule to make topical agent in 7-15 days, this topical agent is the agent of low sour water alcohol.Whole body tinea disease all is suitable for, and notes not using mucosa, wound, pudendum organ, than the careful usefulness of book skin (oxter, abdominal part ditch, pudendum).

Embodiment eight

(1) it is standby to take by weighing the horse hair oil of Herba Artemisiae Annuae volatile oil 4g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 30g, Oleum Verniciae fordii 25g, Oleum Camelliae 30g and capacity;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei according to the extracting method of embodiment one respectively medicinal liquid A, B are standby;

(3) behind the effective ingredient with medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Oleum Camelliae, Oleum Verniciae fordii mixing and stirring cost medicine, after stirring, add horse hair oil to 100 milliliter again, make topical agent through stirring, this topical agent is an oil preparation, at person in middle and old age's autumn and winter skin pruritus; Write for the ease of following, claim that this topical agent is general oil preparation.

Certainly, above embodiment is not limited to and makes 100 milliliters topical agent, if make some more or less topical agent, the material quantity of effective ingredient and carrier just correspondingly increases or reduces.

The clinical observation of [test example] this medicine antifungal therapy skin tinea

Totally 188 routine tinea disease patient reception tests, male's 98 examples, women's 90 examples, tinea capitis 38 examples wherein, tinea corporis 31 examples, tinea cruris 29 examples, tinea manus and pedis 62 examples, tinea unguium 28 examples.Experimenter's 70% case had been accepted to recur after 1～3 kind of tincture of controlling the tinea disease or the Ointment in Treatment and had been tried.The some months that the course of disease is short, long 3～5 years, the case stubborn dermatitis that has and read the strain bacterium property paronychia course of disease and more reach 5～9 years was with the tired obstinate case of controlling tired of various medicines.

One, administrated method:

1, conventional usage: the agent of high sour water alcohol, low sour water alcohol agent and oil preparation medication every day 3～4 times, each 1～3 milliliter (time spent shakes up earlier, shakes up promptly to use), fortnight is 1 course of treatment, stops second course of treatment of reuse after 1 course of treatment 2～3 days.Do not contact water after the medication in 2 hours, liquid medicine is not to the fine and site of injury wound of eye during medication.

Children: usage and dosage is not bright in half cycle year, and careful usefulness of one full year of life in half cycle year to one is used oil preparation on a small quantity, low sour water alcohol agent of careful usefulness of 1-2 one full year of life and oil preparation, and a small amount of the use; 3-5 one full year of life is used (within 1 milliliter) on a small quantity with low sour water alcohol agent or oil preparation.Redden as the colour of skin and to stop using immediately.

2, the using method of suiting the medicine to the illness:

1. skin tinea (not comprising skin book place tinea such as oxter, abdominal part ditch) can use medicine of the present invention, and is more effective in cure by following usage.

2. head, body, tinea cruris are with hanging down sour water alcohol agent and wholesomeness oil preparation.

3. hands, foot, first stubborn dermatitis are used the wholesomeness oil preparation with after course of treatment of the pure agent of high sour water earlier.

4. the serious tinea disease wholesomeness oil preparation of skin lesion, coating is from a small quantity.(cumulative to normal amount) by 1 milliliter of beginning

5. middle-aged and elderly people autumn and winter fungus skin pruritus and epidermis ringworm are treated with general oil preparation.Also available wholesomeness oil preparation.

6. skin book place tinea disease such as oxter, abdominal part ditch is careful with oil preparation with forbid the agent of high sour water alcohol, the agent of low sour water alcohol.

During the treatment, scrape every day and wash the affected part, remove crust knot thing, make medicine easily infiltrate focus, paronychia was used to scrape through the disinfectant bamboo tooth pick and is washed nail groove crust knot thing in per 3～5 days, and thorn decreases nail groove, otherwise medicine is to wound meeting inflammation.As scrape and wash the back medication redness to occur be to scrape the damage epidermis, due to medicine was invaded too much, drug withdrawal can continue medication after 2 days.

Attention:

1. stop using immediately as irritated dermatitis occurring, use the hot water injection, coat desensitization anti-inflammatory ointment.

2. this medicine is forbidden the large tracts of land medication, because of oil preparation influences the pore heat rejection function.A large amount of salicylic acid can be poisoned, and forbid medicine to wound, in case inflammation.

3. this medicine is forbidden in mucosa, wound and pudendum organ.

Two, efficacy determination: 1, cure: skin lesion pruritus transference cure.2, significantly effectively: 75% above skin lesion and pruritus card shape disappear.3, effective: 50% above skin lesion and pruritus sx.4, invalid: medication skin lesion pruritus two courses of treatment symptom does not have improvement.

Three, clinical observation result: modern medicine study confirms that this medicine can effectively dissolve cutin, and the drug effect penetration is strong, and the long-acting broad-spectrum antibacterial effect is arranged, and interruption and long-term prescription do not find to produce the drug resistance phenomenon.Medication does not have the generation untoward reaction in accordance with regulations, and personal allomeric function and internal organs are had no side effect.Radix Strophanthi Divaricati through the present embodiment method fry in shallow oil carry precipitate with ethanol after, carry out external with usage and dosage of the present invention and do not have and have side effects.Modern medicine (new pharmacology) proves also that with this medicine system vein cardiotonic this medicine can be used for the mankind, and is nontoxic to human body.

According to clinical observation: be coated with this medicine according to the observation and put various fungus tinea diseases on the skin, 1～3 day skin lesion pruritus of medication doing well,improving 70%; 1 course of treatment of medication, 60% patient's skin lesion and pruritus transference cure reach clinical cure, 20% patient's produce effects, and 20% is effective.Adhere to the medication case of 1 to 6 course of treatment by Therapeutic Method, cure 169 examples, cure rate reaches 90%, produce effects 12 examples, and invalid have 7 examples (1 the automatic drug withdrawal course of treatment).Tracing observation 86 examples had 16 example recurrences in 2 years, relapse rate reaches 20%.It is still effective to reuse this medicine treatment, does not produce drug resistance.

The drug toxicology reaction:

This medicine is in the local skin external, and below 1/10, each medication is no more than half bottle (5ml) to area, can use to 1 bottle as healthy and strong adult less than the health area, and safety has no adverse reaction, and is not bright as yet above reaching the large tracts of land systemic administration more than the 10ml.The of short duration pain of slightly itching was felt in the part after the heavier tinea disease of part skin lesion people applied ointment, as the disappearance (because of containing 60% ethanol) in 1～2 hour of ethanol zest.

All 1～2 short week of patient's medication, long half a year, the multiple obstinate case medication that has reaches 1 year, and the whole skin internal organs are discovery feature and organic symptom not.

Press:

Oleum Verniciae fordii and Oleum Verniciae fordii are for oral administration poisonous, and being that traditional Chinese medical science conventional surgical is commonly used controls carbuncle scabies skin infection dermatitis medicine, and because of it has broad-spectrum antibacterial action, therapeutic effect is good, so select it for use, if Oleum Verniciae fordii does not meet modern pharmacology, can only use Oleum Camelliae without Oleum Verniciae fordii.

The former medicine decoct of Radix Strophanthi Divaricati high concentration liquid is used for washout and has put on the skin outward to itching to the inflammation effect, so the traditional Chinese medical science is called toxic medicament, modern removes noxious substance twice, and join Radix Et Rhizoma Rhei and separate its poison and help its antifungal through water extract-alcohol precipitation, a small amount of external has good antifungic action, and the antimicrobial spectrum broadness; There is not toxicity less than the wound mucosa.Surplus 180, have only 8 examples to read strain bacterium property paronychia among the routine experimenter, local red and swollen because of scraping the medication generation of thorn damage back, dissipated voluntarily in 3～5 days after the drug withdrawal, need not the medication treatment.Reason is that Wound medicine infiltrates too much, and Radix Strophanthi Divaricati wherein, salicylic acid, ethanol stimulate and causes.Modern medicine is made quiet of Radix Strophanthi Divaricati cardiotonic (new pharmacology) with Radix Strophanthi Divaricati, proves that also preparation can be used for human body and has no adverse reaction.

Claims (14)

1. the medicine of an antifungal therapy skin tinea, it is the topical agent of making by effective ingredient and pharmaceutically acceptable carrier, it is characterized in that, in per 100 milliliters topical agent, described effective ingredient mainly is to be made by following raw material by weight ratio: Herba Artemisiae Annuae volatile oil 4～18g, Radix Strophanthi Divaricati 20～50g, Radix Et Rhizoma Rhei 10～40g.

2. medicine according to claim 1 is characterized in that, described active ingredient raw materials also comprises: salicylic acid 3～10g, benzoic acid 0.2～0.3g; Described carrier is selected 95% concentration ethanol solution and glycerol for use, and in per 100 milliliters topical agent, the amount ranges of glycerol is 5～15g.

3. medicine according to claim 2 is characterized in that, the consumption of described each active ingredient raw materials is: Herba Artemisiae Annuae volatile oil 8g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 30g, salicylic acid 8g, benzoic acid 0.3g; In the carrier, the consumption of glycerol is 6g.

4. medicine according to claim 1 is characterized in that, described active ingredient raw materials also comprises: Pericarpium Zanthoxyli volatile oil 3～9g, Oleum Verniciae fordii or Oleum Camelliae 30～40g; Described carrier is a horse hair oil.

5. medicine according to claim 4 is characterized in that, the consumption of described active ingredient raw materials is: Herba Artemisiae Annuae volatile oil 12g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 20g, Pericarpium Zanthoxyli volatile oil 6g, Oleum Verniciae fordii or Oleum Camelliae 38g.

6. medicine according to claim 1 is characterized in that, described active ingredient raw materials also comprises: Pericarpium Zanthoxyli volatile oil 3～6g, salicylic acid 3～8g, benzoic acid 0.2～0.3g; Described carrier is 95% concentration ethanol solution.

7. medicine according to claim 6 is characterized in that, the consumption of described each active ingredient raw materials is: Herba Artemisiae Annuae volatile oil 12g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 20g, Pericarpium Zanthoxyli volatile oil 6g, salicylic acid 6g, benzoic acid 0.2g.

8. medicine according to claim 1 is characterized in that, the consumption of described each active ingredient raw materials is: Oleum Verniciae fordii 20～30g, Oleum Camelliae 26～40g; Described carrier is a horse hair oil.

9. medicine according to claim 8 is characterized in that, the consumption of described each active ingredient raw materials is: Herba Artemisiae Annuae volatile oil 4g, Radix Strophanthi Divaricati 50g, Radix Et Rhizoma Rhei 30g, Oleum Verniciae fordii 25g, Oleum Camelliae 30g.

10. a method for preparing the described medicine of claim 1 is characterized in that comprising the following steps:

(1) it is standby to take by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei according to the active ingredient raw materials weight proportion;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B;

(3) with the effective ingredient of Herba Artemisiae Annuae volatile oil and medicinal liquid A, B mixing and stirring cost medicine, make topical agent with pharmaceutically acceptable carrier again.

11. the preparation method of any described medicine of claim 2 to 3 is characterized in that comprising the following steps:

(1) takes by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, salicylic acid, benzoic acid, glycerol and 95% enough concentration ethanol solution for standby according to the raw material weight proportioning;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B;

(3) earlier with salicylic acid and benzoic acid and glycerol with the dissolving of part 95% concentration ethanol solution, add medicinal liquid A, B and Herba Artemisiae Annuae volatile oil again, shake and evenly add 95% concentration ethanol solution stirring again and evenly make topical agent.

12. the preparation method of any described medicine of claim 4 to 5 is characterized in that comprising the following steps:

(1) according to the raw material weight proportioning take by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, Pericarpium Zanthoxyli volatile oil, Oleum Verniciae fordii or Oleum Camelliae, horse hair oil is standby;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B;

(3), add Oleum Verniciae fordii or Oleum Camelliae again and horse hair oil is evenly made topical agent with the effective ingredient of medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Pericarpium Zanthoxyli volatile oil mix homogeneously cost medicine.

13. the preparation method of any described medicine of claim 6 to 7 is characterized in that comprising the following steps:

(1) takes by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, salicylic acid, benzoic acid, Pericarpium Zanthoxyli volatile oil and 95% enough concentration ethanol solution for standby according to the raw material weight proportioning;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B;

(3) earlier with salicylic acid, benzoic acid and glycerol with the dissolving of part 95% concentration ethanol solution, add medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Pericarpium Zanthoxyli volatile oil again, shake and evenly add 95% concentration ethanol solution stirring again and evenly make topical agent.

14. the preparation method of any described medicine of claim 8 to 9 is characterized in that comprising the following steps:

(1) take by weighing Herba Artemisiae Annuae volatile oil, Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei, Oleum Verniciae fordii, Oleum Camelliae according to the raw material weight proportioning and enough horse hair oil standby;

(2) Radix Strophanthi Divaricati, Radix Et Rhizoma Rhei are used the decoction and alcohol sedimentation technique effective component extracting respectively, and respectively correspondence to be condensed into the raw material weight ratio be 0.95: 10 medicinal liquid, respectively add again 95% concentration ethanol solution transfer to the raw material weight ratio be 1: 5, standby to deserved medicinal liquid A, B;

(3), add horse hair oil again and stir and make topical agent with the effective ingredient of medicinal liquid A, B and Herba Artemisiae Annuae volatile oil, Oleum Verniciae fordii, Oleum Camelliae mixing and stirring cost medicine.