CN105125470A - Hydrogel microcapsule for oil control and acne removal - Google Patents
Hydrogel microcapsule for oil control and acne removal Download PDFInfo
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Abstract
The invention discloses a hydrogel microcapsule for oil control and acne removal. The hydrogel microcapsule is composed of a capsule wall and a capsule core. The capsule core is prepared from, by weight, 5-10 parts of oil absorbing powder, 40-50 parts of fresh aloe vera juice, 3-8 parts of bee milk extracts, 2-10 parts of salvia miltiorrhiza extracts, 1-5 parts of licorice extracts, 1-5 parts of sugar kelp extracts, 1-5 parts of apple blossom extracts, 1-5 parts of allantoin, 5-10 parts of tea tree oil, 0.01-0.1 part of compound corrosion remover and the balance deionized water, and the total weight of the capsule core is supplemented to 100 parts. The compound corrosion remover is prepared from, by weight, 1-20 parts of plant root extracts, 1-20 parts of plant flower extracts, 10-20 parts of plant leaf extracts and 1-10 parts of plant peel extracts. By means of the hydrogel microcapsule for oil control and acne removal, oil secretion can be lowered, skin grease is absorbed, good acne removal, scar removal and skin repairing promotion effects are achieved, the hydrogel microcapsule can be used for preventing and treating whelks, the effect is obvious, the fast effect is achieved, and no trace is left after healing.
Description
Technical field
The present invention relates to household chemicals field, particularly a kind of hydrogel microcapsule controlling oily anti-acne.
Background technology
For acne skin that is neutral and oiliness, the secretion of its skin oil and fat is vigorous, easily causes oils and fats to pile up at forehead, wing of nose place, and many corse sweat pore, and skin is thick firmly rough.The oils and fats of too much secretion easily causes the blocking of pore, the growing of blackhead and small pox, and at present, a lot of anti-acne (acne of dispelling) product uses hormone, antibiotic, retinoic acid, the compositions such as fruit acid, zest is large, and easily cause skin to the drug resistance of Propiobacterium, safety is constantly under suspicion.Such as, often be used as acne, itch-stopping bactericidal, the cuticular salicylic acid of softening skin just can not consumption more than 0.5%, and uses rear xerosis cutis, can produce tight sense, and in existing natural composition product for resolving poxes, often just single selection natural extract carrys out anti-inflammation and sterilization, does not solve problem for the antibacterial of caused acne, so the speed that takes effect is not often very fast.Little to skin irritation, gentle, effective product for resolving poxes, has become the primary selection of nowadays acne skin fast, particularly along with people's living standard improves constantly, also more and more higher to requirement that is healthy and environmental protection.
Summary of the invention
The invention provides a kind of hydrogel microcapsule controlling oily anti-acne, it can reduce fat secretion, absorb skin oil and fat, and has good anti-acne, scar eliminating and promote skin repair effect, prevention and therapy comedo can be used for, its successful, effect is fast, without vestige after curing.
The present invention is achieved in that a kind of hydrogel microcapsule controlling oily anti-acne, be made up of cyst wall and capsule-core, described capsule-core is made up of the following each component with weight portion: 5 ~ 10 parts, oil suction powder, fresh aloe juice 40 ~ 50 parts, Lac regis apis extract 3 ~ 8 parts, Radix Salviae Miltiorrhizae extract 2 ~ 10 parts, Radix Glycyrrhizae extract 1 ~ 5 part, sugared Thallus Laminariae (Thallus Eckloniae) extract 1 ~ 5 part, flower of Fructus Mali pumilae extract 1 ~ 5 part, allantoin 1 ~ 5 part, tea tree oil 5 ~ 10 parts and Compositional antiseptic agent 0.01 ~ 0.1 part, surplus is deionized water, complements to 100 parts, described Compositional antiseptic agent is made up of the following each component with weight portion: plant roots extract 1 ~ 20 part, Plant flawer extracts 1 ~ 20 part, leaves of plants extract 10 ~ 30 parts and plant peel extract 1 ~ 10 part, described plant roots extract is by Radix Scutellariae 1 ~ 5 part, Radix Sophorae Flavescentis 0.1 ~ 1 part, 0.1 ~ 1 part, moss and Herba Houttuyniae 1 ~ 5 part of mixed extraction obtain, described Plant flawer extracts is obtained by Flos Inulae 5 ~ 10 parts and Flos Hibisci Mutabilis 1 ~ 10 part of mixed extraction, described leaves of plants extract is by 1 ~ 10 part, Folium Nelumbinis, Folium Ginkgo 5 ~ 10 parts, leaf of Herba Rosmarini Officinalis 2 ~ 5 parts, 1 ~ 5 part, Folium olive and Folium Perillae 5 ~ 10 parts of mixed extraction obtain, described plant peel extract is obtained by pomelo peel 5 ~ 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 1 ~ 5 part of mixed extraction.
The present invention has following beneficial effect: oily for control anti-acne active component is embedded in cyst wall as capsule-core by the hydrogel microcapsule of control oil anti-acne of the present invention, make it not by the interference of outside environmental elements, keep stable biological activity, realize continuing control oil and acne-removing, epidermis antibacterial and hair follicle root bacillus can be killed fast, effective happy pore, cleaning hair follicle, collection oil suction, antiinflammatory, sterilization, accelerating, Bergamot Mint Extract is in one; Can reduce fat secretion, absorb skin oil and fat, and have good anti-acne, scar eliminating and promote skin repair effect, the abilities such as anti-acne effect are higher than commercially available prod; And scientific formulation of the present invention, dosage is applicable to, cheap, and curative effect is rapidly, significantly; This hydrogel microcapsule, quality is light and handy, and be convenient for carrying, can meet the requirement of carrying with, application is better.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention, is not limitation of the invention.
Fresh aloe juice is obtained by following methods: select organic Aloe Barbadensis Miller fresh leaf (fresh leaf of U.S.'s Curacao, trophophase more than 2 years, pollution-free disease-free) as raw material, after cleaning, sterilizing, remove end to end, trimming peeling, grind process, one-step method process that the Aloe gel after grinding is taked " stabilisation and sterilizing ", then be cooled to less than 40 DEG C rapidly with liquid nitrogen, then be aseptically separated by gravy, obtain the fresh juice of organic aloe.Wherein stabilisation sterilization treatment refers to by adding 0.23% citric acid and 0.085%EDTA-2Na in the Aloe gel after grinding respectively as acidulant, chelating agen, by heat treatment (85 DEG C), passivation is carried out to the enzyme in Aloe gel, to realize Aloe gel stabilisation sterilization treatment.In addition, in processing procedure, any enzyme should not be added.
It is a kind of ω-hydroxy acid be present in nature Lac regis apis that Lac regis apis extract contains 10-hydroxydecanoic acid, decanedioic acid, decanediol and 10-HDA, 10-HDA, and the Lac regis apis extract in the present invention is the AcnacidolBG purchased from ISP company.
Radix Salviae Miltiorrhizae extract is obtained by following methods: get salvia piece, adds 10 times of water gagings of Radix Salviae Miltiorrhizae dry weight, under reduced pressure, 75 DEG C of extractions 3 times of seething with excitement, each 2.5h, merge extractive liquid, filter, less than 60 DEG C concentrating under reduced pressure, are concentrated into the clear paste that relative density is 1.2, clear paste is 190 DEG C in spray dryer inlet temperature, and outlet temperature is 80 DEG C, under moisture less than 8% condition, carry out spraying dry, the granule that spraying dry obtains is pulverized, and crosses 80 mesh sieves, obtains Radix Salviae Miltiorrhizae extract.Radix Salviae Miltiorrhizae extract has the functions such as promoting blood flow to regulate menstruation, promoting tissue regeneration by removing blood stasis, tranquillizing and allaying excitement, removing heat from blood eliminating carbuncle, reducing swelling and alleviating pain.In Radix Salviae Miltiorrhizae, active component TANSHINONES has antibacterial action, extremely sensitive to Propiobacterium, and be a kind of estrogen-like product of mitigation, play anti-androgen effect, also there is the antiinflammatory action of similar hydrocortisone simultaneously, strong to gram-positive bacteria antibacterial action, obviously can reduce propionibacterium acnes counting, and can suppress acute and react with subacute inflammation, there is antiinflammatory action.Still have gentle estrogenic activity and anti-in acid andrusol effect, anti-androgenic effect and the effect of anti-sebum glandular secretion definite.Gonadal hormone especially androgen has close relationship with the generation of acne, development, persistent state.TANSHINONES avoids application estrin treatment acne usually, and the shortcoming of interference patient body intracellular metabolite, improves the clinical symptoms of acne from many aspects. and subject range is wider.In addition, the blood circulation promoting and blood stasis dispelling function that TANSHINONES has still raised path between farm fields improves the blood circulation of face, promotes the metabolism of affected skin.
Radix Glycyrrhizae extract is obtained by following methods: according to 1:5 weight ratio, drops into ethanol and carries out extracting, filtering, obtain extracting solution in Radix Glycyrrhizae; Extracting solution is concentrated, makes the concentration ratio of extracting solution simmer down to 30 Brix degree; Add distilled water according to the ratio of 1:2 in extracting solution after above-mentioned concentrating, the extracting solution after concentrated is washed; Extracting solution after washing carries out concentrating under reduced pressure again; Extracting solution after concentrated is carried out drying, obtains Radix Glycyrrhizae extract.Radix Glycyrrhizae has the anti-aging effect of whitening antiinflammatory.
Sugar Thallus Laminariae (Thallus Eckloniae) extract is brown algae extract; Preferably purchased from Féraud stamen gold and/or the Féraud stamen gold BG of MarineBiotech, France, can also be that the product being HG657 from the product designation of Ennagram, France company obtains.Sugar Thallus Laminariae (Thallus Eckloniae) extract can regulation of skin fat secretion well, significantly improves sebum overflow, suppresses the inflammation that lipolytic enzyme causes, rebuild skin physiology balance.
This flower of Fructus Mali pumilae extract is obtained by following methods: finishing collecting apple flower is positioned in pulverizer cylinder body, adds the ethanol mixing that concentration is 65%, carries out historrhexis 3 times, each 10 minutes, then leave standstill 3 hours, obtain mixed liquor with the rotating speed of 5000r/min; With membrane filtration, obtain feed liquid; Feed liquid is positioned in distillator and distills, obtain concentrate; Concentrate is placed in oil water separator and is separated, obtain flower of Fructus Mali pumilae extract.Apple flower mouthfeel is unique, have enrich blood or alleviate neuralgia, improving eyesight of enriching blood, pox-eliminating whitening effect.
Described oil suction powder is the mixture of starch ocentyl succinic aluminum, acrylic copolymer, magnesium carbonate composition, and wherein the part by weight of starch ocentyl succinic aluminum, acrylic copolymer, magnesium carbonate is 3:2:1.This oil suction powder is the modified starch of a oil absorption, and oil absorption is outstanding, energy deep layer cleaning skin, the oils and fats piled up in sucking-off pore and dirt.
Plant roots extract is obtained by following methods: finishing collecting Radix Scutellariae, Radix Sophorae Flavescentis, moss and Herba Houttuyniae are positioned in pulverizer cylinder body, add ethanol mixing (liquid material mass ratio is 25:1) that concentration is 64%, soak 3h, historrhexis is carried out 4 times with the rotating speed of 10000r/min, each 8 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 15%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 35%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product.
Plant flawer extracts is obtained by following methods: finishing collecting Flos Hibisci Mutabilis and Flos Inulae are positioned in pulverizer cylinder body, add ethanol mixing (liquid material mass ratio is 12:1) that concentration is 52%, soak 3h, historrhexis is carried out 2 times with the rotating speed of 5000r/min, each 5 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 5%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 15%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product.
Leaves of plants extract is obtained by following methods: finishing collecting Folium Nelumbinis, Folium Ginkgo, leaf of Herba Rosmarini Officinalis, Folium olive and Folium Perillae are positioned in pulverizer cylinder body, add ethanol mixing (liquid material mass ratio is 20:1) that concentration is 58%, soak 3h, historrhexis is carried out 3 times with the rotating speed of 8000r/min, each 8 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 15%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 28%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product.
Plant peel extract is obtained by following methods: finishing collecting pomelo peel and Cortex cinnamomi japonici (Ramulus Cinnamomi) are positioned in pulverizer cylinder body, add ethanol mixing (liquid material mass ratio is 10:1) that concentration is 55%, soak 3h, historrhexis is carried out 3 times with the rotating speed of 5000r/min, each 8 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 8%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 20%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product.
Embodiment 1 to 5, comparative example 1 to 3, concrete formula proportion is in table 1.The present invention has the hydrogel microcapsule controlling oily anti-acne effect and adopts dropping preparation method preparation, specifically comprises the steps: plant roots extract, Plant flawer extracts, leaves of plants extract and plant peel extract Homogeneous phase mixing to obtain plant Compositional antiseptic agent; The mixing of polymethylacrylic acid, hydroxypropyl emthylcellulose and silver color shimmering powder is dissolved in 100ml deionized water, and heated and stirred is even, obtains capsule wall solution; Oil suction powder, fresh aloe juice, Lac regis apis extract, Radix Salviae Miltiorrhizae extract, Radix Glycyrrhizae extract, sugared Thallus Laminariae (Thallus Eckloniae) extract, flower of Fructus Mali pumilae extract, allantoin, tea tree oil, Compositional antiseptic agent are added in deionized water, heated and stirred is even, and under the homogenization pressure of 45MPa, homogenizing 3min, obtains capsule-core solution.Dropping preparation method is used to prepare hydrogel microcapsule, the capsule wall solution stirred flows out from water dropper outside, the core materials that homogenizing is good flows out from water dropper inside, form a sandwich fluid column, then fluid column is cut off with sickle, form the drop that a series of diameter is 10mm, capsule-core is 1:3 with cyst wall diameter ratio, be prepared into hydrogel microcapsule.Wherein, described Compositional antiseptic agent is made up of the following each component with weight portion: plant roots extract 8 parts, Plant flawer extracts 10 parts, leaves of plants extract 20 parts and plant peel extract 5 parts, described plant roots extract is obtained by Radix Scutellariae 1 part, Radix Sophorae Flavescentis 1 part, 0.1 part, moss and Herba Houttuyniae 1 part of mixed extraction, described Plant flawer extracts is obtained by Flos Inulae 5 parts and Flos Hibisci Mutabilis 10 parts of mixed extraction, and described leaves of plants extract is obtained by 1 part, Folium Nelumbinis, Folium Ginkgo 5 parts, leaf of Herba Rosmarini Officinalis 2 parts, 2 parts, Folium olive and Folium Perillae 8 parts of mixed extraction; Described plant peel extract is obtained by pomelo peel 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5 parts of mixed extraction.
This controls the hydrogel microcapsule efficacy test of oily anti-acne:
1. tester's data
At random patient is divided into embodiment 1 ~ 5 group, comparative example 1 ~ 3 group and 1 group, commercially available prod.Embodiment 1 group of 25 example, 17 ~ 38 years old age, 21.2 years old mean age, man 10 example, female 15 example; Embodiment 2 group of 25 example, 16 ~ 38 years old age, 22 years old mean age, man 11 example, female 14 example; Embodiment 3 group of 25 example, 18 ~ 37 years old age, 21.5 years old mean age, man 13 example, female 12 example; Embodiment 4 group of 25 example, 16 ~ 40 years old age, 24 years old mean age, man 8 example, female 17 example; Embodiment 5 group of 25 example, age 18 ~ 39,23 years old mean age, man 11 example, female 14 example.Comparative example 1 group of 25 example, 17 ~ 40 years old age, 22 years old mean age, man 15 example, female 10 example; Comparative example 2 group of 25 example, 16 ~ 38 years old age, 24 years old mean age, man 13 example, female 12 example; Comparative example 3 group of 25 example, 18 ~ 38 years old age, 22.8 years old mean age, man 9 example, female 16 example.1 group 25, commercially available prod example, 16 ~ 37 years old age, 23.6 years old mean age, man 12 example, female 13 example.
2. method of testing and effect standard
(1) with reference to " new Chinese medicine guideline of clinical investigations ", Evaluation of Synthetic Effect of Holistic calculates curative effect rate with the total mark of skin lesion degree, skin lesion distribution, symptom, sign.Skin lesion counting * 100% before curative effect=(before treatment the rear skin lesion counting of skin lesion counting-treatment)/treatment.Cure: skin lesion disappears more than 90%, only has a little pigmentation; Effective: skin lesion disappears 60% ~ 90%, and symptom alleviates; Effective: skin lesion disappears 20% ~ 60%, symptom is improved; Invalid: skin lesion disappears <20%, and clinical symptoms is not improved.Total effective rate=cure rate+obvious effective rate+effective percentage.Test result is in table 1.
(2) fat secretion reduction test: detect respectively with oils and fats measuring instrument and use before product and use product after 24 hours, skin surface fat content, the reduction of calculating skin surface fat content, average, test evaluation the results are shown in Table 1.
(3) lasting fat secretion reduction: use product 1 week continuously, with oils and fats measuring instrument detection of skin surface fat content, product of stopping using, after 28 days, then detection of skin surface fat content, calculate the lasting fat secretion reduction of skin, average, test evaluation the results are shown in Table 1.
(4) cure the time of acne: use product, see to look into and cure the time used, average, test evaluation the results are shown in Table 1.
Using method: be coated with hydrogel microcapsule after tester cleans face outside skin lesion place, every day each 1 time sooner or later.Not in shower, shave or use within 2 hours and 30 minutes afterwards before strenuous exercise (as causing perspiration).
Table 1 embodiment of the present invention 1 ~ 5 and comparative example 1 ~ 3 and test result
Embodiment 6
A capsule-core containing the oily anti-acne active component of control, is made up of the following each component with weight portion: 8 parts, oil suction powder, fresh aloe juice 45 parts, Lac regis apis extract 4 parts, Radix Salviae Miltiorrhizae extract 6 parts, Radix Glycyrrhizae extract 3 parts, sugared Thallus Laminariae (Thallus Eckloniae) extract 2 parts, flower of Fructus Mali pumilae extract 3 parts, allantoin 2 parts, tea tree oil 12 parts, Compositional antiseptic agent 0.05 part and deionized water 14.95 parts; Wherein Compositional antiseptic agent, be made up of the following each component with weight portion: plant roots extract 5 parts, Plant flawer extracts 10 parts, leaves of plants extract 15 parts and plant peel extract 10 parts, described plant roots extract is obtained by Radix Scutellariae 1 part, Radix Sophorae Flavescentis 0.1 part, 1 part, moss and Herba Houttuyniae 2 parts of mixed extraction, described Plant flawer extracts is obtained by Flos Inulae 5 parts and Flos Hibisci Mutabilis 10 parts of mixed extraction, and described leaves of plants extract is obtained by 1 part, Folium Nelumbinis, Folium Ginkgo 10 parts, leaf of Herba Rosmarini Officinalis 5 parts, 5 parts, Folium olive and Folium Perillae 8 parts of mixed extraction; Described plant peel extract is obtained by pomelo peel 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10 parts of mixed extraction.
Embodiment 7
A capsule-core containing the oily anti-acne active component of control, is made up of the following each component with weight portion: 8 parts, oil suction powder, fresh aloe juice 45 parts, Lac regis apis extract 4 parts, Radix Salviae Miltiorrhizae extract 6 parts, Radix Glycyrrhizae extract 3 parts, sugared Thallus Laminariae (Thallus Eckloniae) extract 2 parts, flower of Fructus Mali pumilae extract 3 parts, allantoin 2 parts, tea tree oil 12 parts, Compositional antiseptic agent 0.05 part and deionized water 14.95 parts; Wherein Compositional antiseptic agent, be made up of the following each component with weight portion: plant roots extract 8 parts, Plant flawer extracts 5 parts, leaves of plants extract 20 parts and plant peel extract 8 parts, described plant roots extract is obtained by Radix Scutellariae 3 parts, Radix Sophorae Flavescentis 0.5 part, 0.1 part, moss and Herba Houttuyniae 5 parts of mixed extraction, described Plant flawer extracts is obtained by Flos Inulae 8 parts and Flos Hibisci Mutabilis 6 parts of mixed extraction, and described leaves of plants extract is obtained by 5 parts, Folium Nelumbinis, Folium Ginkgo 5 parts, leaf of Herba Rosmarini Officinalis 4 parts, 3 parts, Folium olive and Folium Perillae 10 parts of mixed extraction; Described plant peel extract is obtained by pomelo peel 8 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 7 parts of mixed extraction.
Embodiment 8
A capsule-core containing the oily anti-acne active component of control, is made up of the following each component with weight portion: 8 parts, oil suction powder, fresh aloe juice 45 parts, Lac regis apis extract 4 parts, Radix Salviae Miltiorrhizae extract 6 parts, Radix Glycyrrhizae extract 3 parts, sugared Thallus Laminariae (Thallus Eckloniae) extract 2 parts, flower of Fructus Mali pumilae extract 3 parts, allantoin 2 parts, tea tree oil 12 parts, Compositional antiseptic agent 0.05 part and deionized water 14.95 parts; Wherein Compositional antiseptic agent, be made up of the following each component with weight portion: plant roots extract 10 parts, Plant flawer extracts 8 parts, leaves of plants extract 24 parts and plant peel extract 5 parts, described plant roots extract is obtained by Radix Scutellariae 5 parts, Radix Sophorae Flavescentis 1 part, 0.5 part, moss and Herba Houttuyniae 1 part of mixed extraction, described Plant flawer extracts is obtained by Flos Inulae 10 parts and Flos Hibisci Mutabilis 1 part of mixed extraction, and described leaves of plants extract is obtained by 10 parts, Folium Nelumbinis, Folium Ginkgo 1 part, leaf of Herba Rosmarini Officinalis 2 parts, 1 part, Folium olive and Folium Perillae 5 parts of mixed extraction; Described plant peel extract is obtained by pomelo peel 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 1 part of mixed extraction.
Comparative example 4
A capsule-core containing the oily anti-acne active component of control, is made up of the following each component with weight portion: 8 parts, oil suction powder, fresh aloe juice 45 parts, Lac regis apis extract 4 parts, Radix Salviae Miltiorrhizae extract 6 parts, Radix Glycyrrhizae extract 3 parts, sugared Thallus Laminariae (Thallus Eckloniae) extract 2 parts, flower of Fructus Mali pumilae extract 3 parts, allantoin 2 parts, tea tree oil 12 parts, Compositional antiseptic agent 0.05 part and deionized water 14.95 parts; Wherein Compositional antiseptic agent, be made up of the following each component with weight portion: plant roots extract 5 parts and Plant flawer extracts 10 parts, described plant roots extract is obtained by Radix Scutellariae 1 part, Radix Sophorae Flavescentis 0.1 part, 1 part, moss and Herba Houttuyniae 2 parts of mixed extraction, and described Plant flawer extracts is obtained by Flos Inulae 5 parts and Flos Hibisci Mutabilis 10 parts of mixed extraction.
Comparative example 5
A capsule-core containing the oily anti-acne active component of control, is made up of the following each component with weight portion: 8 parts, oil suction powder, fresh aloe juice 45 parts, Lac regis apis extract 4 parts, Radix Salviae Miltiorrhizae extract 6 parts, Radix Glycyrrhizae extract 3 parts, sugared Thallus Laminariae (Thallus Eckloniae) extract 2 parts, flower of Fructus Mali pumilae extract 3 parts, allantoin 2 parts, tea tree oil 12 parts, Compositional antiseptic agent 0.05 part and deionized water 14.95 parts; Wherein Compositional antiseptic agent, is made up of the following each component with weight portion: leaves of plants extract 20 parts, and described leaves of plants extract is obtained by 5 parts, Folium Nelumbinis, Folium Ginkgo 5 parts, 3 parts, Folium olive and Folium Perillae 10 parts of mixed extraction.
Comparative example 6
A capsule-core containing the oily anti-acne active component of control, is made up of the following each component with weight portion: 8 parts, oil suction powder, fresh aloe juice 45 parts, Lac regis apis extract 4 parts, Radix Salviae Miltiorrhizae extract 6 parts, Radix Glycyrrhizae extract 3 parts, sugared Thallus Laminariae (Thallus Eckloniae) extract 2 parts, flower of Fructus Mali pumilae extract 3 parts, allantoin 2 parts, tea tree oil 12 parts, antiseptic 0.05 part and deionized water 14.95 parts; Described antiseptic is methyl parahydroxybenzoate.
Microorganism level detects: undertaken canned by the capsule-core dark brown vial that embodiment 6 to 8 and comparative example 4 to 6 obtain respectively, open wide bottle cap, under being placed in the environment of ambient temperature 40 DEG C, relative humidity 85%, continuous observation is also tested, and concrete outcome sees the following form; Test item, detection method and examination criteria carry out according to QB/T2872-2007.
| Observe phenomena | |
| Embodiment 6 | No abnormality seen after 60 days, pure in smell |
| Embodiment 7 | No abnormality seen after 60 days, pure in smell |
| Embodiment 8 | No abnormality seen after 60 days, pure in smell |
| Comparative example 4 | After 50 days, occur mildew, microorganism exceeds standard, and distributes unhappy abnormal smells from the patient |
| Comparative example 5 | After 40 days, occur mildew, microorganism exceeds standard, and distributes unhappy abnormal smells from the patient |
| Comparative example 6 | After 40 days, occur mildew, microorganism exceeds standard, and distributes unhappy abnormal smells from the patient |
| Do not add antiseptic | After 5 days, occur mildew, microorganism exceeds standard, and distributes unhappy abnormal smells from the patient |
The above embodiment only have expressed embodiments of the present invention; it describes comparatively concrete and detailed; but therefore can not be interpreted as the restriction to the scope of the claims of the present invention; in every case the technical scheme adopting the form of equivalent replacement or equivalent transformation to obtain, all should drop within protection scope of the present invention.
Claims (9)
1. control the hydrogel microcapsule of oily anti-acne for one kind, be made up of cyst wall and capsule-core, described capsule-core is made up of the following each component with weight portion: 5 ~ 10 parts, oil suction powder, fresh aloe juice 40 ~ 50 parts, Lac regis apis extract 3 ~ 8 parts, Radix Salviae Miltiorrhizae extract 2 ~ 10 parts, Radix Glycyrrhizae extract 1 ~ 5 part, sugared Thallus Laminariae (Thallus Eckloniae) extract 1 ~ 5 part, flower of Fructus Mali pumilae extract 1 ~ 5 part, allantoin 1 ~ 5 part, tea tree oil 5 ~ 10 parts and Compositional antiseptic agent 0.01 ~ 0.1 part, surplus is deionized water, complements to 100 parts, described Compositional antiseptic agent is made up of the following each component with weight portion: plant roots extract 1 ~ 20 part, Plant flawer extracts 1 ~ 20 part, leaves of plants extract 10 ~ 30 parts and plant peel extract 1 ~ 10 part, described plant roots extract is by Radix Scutellariae 1 ~ 5 part, Radix Sophorae Flavescentis 0.1 ~ 1 part, 0.1 ~ 1 part, moss and Herba Houttuyniae 1 ~ 5 part of mixed extraction obtain, described Plant flawer extracts is obtained by Flos Inulae 5 ~ 10 parts and Flos Hibisci Mutabilis 1 ~ 10 part of mixed extraction, described leaves of plants extract is by 1 ~ 10 part, Folium Nelumbinis, Folium Ginkgo 5 ~ 10 parts, leaf of Herba Rosmarini Officinalis 2 ~ 5 parts, 1 ~ 5 part, Folium olive and Folium Perillae 5 ~ 10 parts of mixed extraction obtain, described plant peel extract is obtained by pomelo peel 5 ~ 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi) 1 ~ 5 part of mixed extraction.
2. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, it is characterized in that: described fresh aloe juice is obtained by following methods: select organic Aloe Barbadensis Miller fresh leaf as raw material, after cleaning, sterilizing, remove end to end, trimming peeling, grind process, one-step method process that Aloe gel after grinding is taked " stabilisation and sterilizing ", be cooled to less than 40 DEG C rapidly with liquid nitrogen again, be then aseptically separated by gravy, obtain the fresh juice of organic aloe; Wherein stabilisation sterilization treatment refers to that interpolation 0.23% citric acid and 0.085%EDTA-2Na are respectively as acidulant, chelating agen, carry out passivation by heat treatment to the enzyme in Aloe gel, to realize Aloe gel stabilisation sterilization treatment.
3. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, is characterized in that: described Lac regis apis extract is the AcnacidolBG purchased from ISP company.
4. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, it is characterized in that: described Radix Salviae Miltiorrhizae extract is obtained by following methods: get salvia piece, add 10 times of water gagings of Radix Salviae Miltiorrhizae dry weight, under reduced pressure, 75 DEG C of extractions 3 times of seething with excitement, each 2.5h, merge extractive liquid, filter, less than 60 DEG C concentrating under reduced pressure, be concentrated into the clear paste that relative density is 1.2, clear paste is 190 DEG C in spray dryer inlet temperature, outlet temperature is 80 DEG C, under moisture less than 8% condition, carry out spraying dry, the granule that spraying dry obtains is pulverized, cross 80 mesh sieves, obtain Radix Salviae Miltiorrhizae extract.
5. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, is characterized in that: described Radix Glycyrrhizae extract is obtained by following methods: according to 1:5 weight ratio, drops into ethanol and carries out extracting, filtering, obtain extracting solution in Radix Glycyrrhizae; Extracting solution is concentrated, makes the concentration ratio of extracting solution simmer down to 30 Brix degree; Add distilled water according to the ratio of 1:2 in extracting solution after above-mentioned concentrating, the extracting solution after concentrated is washed; Extracting solution after washing carries out concentrating under reduced pressure again; Extracting solution after concentrated is carried out drying, obtains Radix Glycyrrhizae extract.
6. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, it is characterized in that: described sugared Thallus Laminariae (Thallus Eckloniae) extract is purchased from MarineBiotech, France Féraud stamen gold and/or Féraud stamen gold BG or from the product designation of Ennagram, France company be HG657 product obtain.
7. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, it is characterized in that: described oil suction powder is the mixture of starch ocentyl succinic aluminum, acrylic copolymer, magnesium carbonate composition, and wherein the part by weight of starch ocentyl succinic aluminum, acrylic copolymer, magnesium carbonate is 3:2:1.
8. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, is characterized in that, described cyst wall is that silver color is translucent, and cyst material comprises gel like material, water soluble film-forming material and silver color shimmering powder.
9. the hydrogel microcapsule of the oily anti-acne of control according to claim 1, it is characterized in that, described plant roots extract is obtained by following methods: finishing collecting Radix Scutellariae, Radix Sophorae Flavescentis, moss and Herba Houttuyniae are positioned in pulverizer cylinder body, add the ethanol mixing that concentration is 64%, liquid material mass ratio is 25:1, soaks 3h, historrhexis is carried out 4 times with the rotating speed of 10000r/min, each 8 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 15%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 35%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product;
Described Plant flawer extracts is obtained by following methods: finishing collecting Flos Hibisci Mutabilis and Flos Inulae are positioned in pulverizer cylinder body, add the ethanol mixing that concentration is 52%, liquid material mass ratio is 12:1, soak 3h, historrhexis is carried out 2 times with the rotating speed of 5000r/min, each 5 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 5%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 15%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product;
Described leaves of plants extract is obtained by following methods: finishing collecting Folium Nelumbinis, Folium Ginkgo, leaf of Herba Rosmarini Officinalis, Folium olive and Folium Perillae are positioned in pulverizer cylinder body, add the ethanol mixing that concentration is 58%, liquid material mass ratio is 20:1, soak 3h, historrhexis is carried out 3 times with the rotating speed of 8000r/min, each 8 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 15%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 28%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product;
Described plant peel extract is obtained by following methods: finishing collecting pomelo peel and Cortex cinnamomi japonici (Ramulus Cinnamomi) are positioned in pulverizer cylinder body, add the ethanol mixing that concentration is 55%, liquid material mass ratio is 10:1, soak 3h, historrhexis is carried out 3 times with the rotating speed of 5000r/min, each 8 minutes, then leave standstill 3 hours, obtain mixed liquor; Then pour in countercurrent extraction machine and extract, obtain coarse filtration liquid; With membrane filtration, obtain preliminary filtrate; Concentrate with reverse osmosis membrane at normal temperatures, obtain the first concentrated solution of solid contents 8%; Get the vacuum concentration that half first concentrated solution carries out at 35 DEG C, obtain the second concentrated solution of solid content 20%; By dry after the first remaining concentrated solution and the mixing of the second concentrated solution, to obtain final product.
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| CN106137935A (en) * | 2016-08-27 | 2016-11-23 | 钱玉连 | A kind of hydrogel facial film controlling oil pore cleanser effect |
| CN107019655A (en) * | 2017-04-24 | 2017-08-08 | 湖南御家化妆品制造有限公司 | Oil control composition and application thereof |
| CN109125133A (en) * | 2018-10-24 | 2019-01-04 | 西安惟颐生物科技有限公司 | Female chest maintains compound essential oil |
| CN112521627A (en) * | 2020-10-14 | 2021-03-19 | 浙江树人学院（浙江树人大学） | Preparation method of green composite hydrogel with slow-release type purification and sterilization functions |
| CN114213676A (en) * | 2021-11-12 | 2022-03-22 | 上海应用技术大学 | Preparation method of natural deep eutectic perilla leaf extract hydrogel |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109125133A (en) * | 2018-10-24 | 2019-01-04 | 西安惟颐生物科技有限公司 | Female chest maintains compound essential oil |
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| CN112521627A (en) * | 2020-10-14 | 2021-03-19 | 浙江树人学院（浙江树人大学） | Preparation method of green composite hydrogel with slow-release type purification and sterilization functions |
| CN112521627B (en) * | 2020-10-14 | 2022-05-03 | 浙江树人学院（浙江树人大学） | Preparation method of green composite hydrogel with slow-release type purification and sterilization functions |
| CN114213676A (en) * | 2021-11-12 | 2022-03-22 | 上海应用技术大学 | Preparation method of natural deep eutectic perilla leaf extract hydrogel |
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Application publication date: 20151209 |