CN107019655B - Oil control composition and application thereof - Google Patents
Oil control composition and application thereof Download PDFInfo
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- CN107019655B CN107019655B CN201710270928.5A CN201710270928A CN107019655B CN 107019655 B CN107019655 B CN 107019655B CN 201710270928 A CN201710270928 A CN 201710270928A CN 107019655 B CN107019655 B CN 107019655B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention relates to an oil control composition, which comprises caprylyl glycine, nicotinamide, inositol, sophorolipid fermentation liquor and a laminaria saccharina extract, wherein the oil control composition adopts nicotinamide, inositol, caprylyl glycine, laminaria saccharina extract and sophorolipid fermentation liquor, oil secretion regulation is carried out on the basis of moisture preservation, and a three-dimensional balance oil control technology is established aiming at the inhibition of the activities of three target points of lipase, 5 α -reductase and sebum flow regulation.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to an oil control composition and application thereof.
Background
The sebaceous gland is an important gland attached to the skin and is an important site for producing sebum. Excess sebum is not only unsightly, but also can cause skin disorders. The cause of sebaceous gland dysfunction is complex, and the formed pathological changes are diversified. Many factors affect sebum secretion, and relate to endocrine secretion, skin moisture, age, sex, dietary nutrition, and the like.
When the sebaceous glands are excessively active, large pores and purely oily skin can be caused, such as acne, seborrheic dermatitis and the like. Therefore, effective regulation of sebaceous gland secretion and controlled discharge of oil are important for maintaining healthy neutral skin conditions. Most oil-control daily chemical products in the market at present only simply clean oil, emphasize water replenishing and moisture keeping, and shrink pores through electrolytes, but only relieve oily skin to a certain extent, but cannot really enable the skin to get rid of oily light. To achieve a permanent cure, the unbalanced sebaceous glands are conditioned.
For abnormal sebaceous gland secretion caused by male hormone, it is also medically regulated by increasing female hormone, for example, progestational-estrol is a low-dose oral contraceptive approved by the U.S. food and drug administration for treating acne, which has obvious side effects of headache, nausea, bleeding, weight gain, chest tenderness, etc.
There is therefore a need to develop an oil-control composition which is safe and effective and does not cause any side effects on the human body and skin.
Disclosure of Invention
Based on this, it is an object of the present invention to provide an oil control composition uniClear.
The specific technical scheme is as follows:
an oil control composition comprising: octanoyl glycine, nicotinamide, inositol, sophorolipid fermentation liquor and Laminaria Saccharina extract.
In some of these embodiments, the oil control composition comprises the following components in parts by weight:
in some of these embodiments, the oil control composition comprises the following components in parts by weight:
in some of these embodiments, the oil control composition comprises the following components in parts by weight:
in some of these embodiments, the laminaria saccharina extract contains 1.0-2.5% active.
In some of these embodiments, the sophorolipid fermentation broth has an active content of 54-66%.
It is another object of the present invention to provide the use of the above oil control composition.
The application of the oil control composition in cosmetics.
In some of these embodiments, the cosmetic comprises a facial cleanser, a toner, a cream, a serum, a cream, a mask, or a color cosmetic.
Another object of the present invention is to provide a cosmetic.
A cosmetic comprises the above oil-controlling composition.
The principle analysis of the invention is as follows:
1 oily skin and sebaceous glands
The sebaceous gland is an important gland attached to the skin and is an important part for producing sebum, and the anatomy and the tissue structure of the human skin indicate that: the sebaceous gland is a vesicular gland which opens more into the upper part of the hair follicle and whose secretion is also increased after the development of the second characteristic, and is significantly affected by androgens. Sebaceous glands can secrete sebum, enter the skin sac through the catheter and then are discharged to the surface of the skin through pores.
Sebum is an oily semi-fluid mixture containing various lipids, mainly comprising triglyceride, fatty acid, phospholipid, cholesterol, etc. Normally excreted sebum has 3 effects: 1) moistening skin and hair; 2) the skin fat and sweat can form a lipid membrane together to protect the skin and prevent the skin moisture from evaporating; 3) sebum exhibits weak acidity and can inhibit and kill bacteria on the skin surface. In addition, sebaceous glands are also important as an epidermal appendage for the maintenance of a stable state of skin balance.
2 factors affecting sebum secretion
Many factors affect sebaceous gland secretion, mainly relating to endocrine quantity, skin moisture, age and sex, and dietary nutrition.
2.1 age and sex
The secretory function of sebaceous glands is relatively strong at birth, drops very low after 6 months, and remains low during childhood. At the beginning of puberty, sebaceous gland secretion increases gradually in both males and females, reaching a peak at age 16-20 and remaining at this level later, with females at age 40 and males after age 50 beginning to decrease sebaceous gland secretion. The sebum secretion rate is higher in men than in women, and this difference decreases with age.
2.2 endocrine secretion
Testosterone increases the volume of the sebaceous gland and increases the secretion, and particularly, 5 α -reductase is overactive in a human body, so that the secretion of dihydrotestosterone is increased, and the sebaceous gland is promoted to be abnormally increased.
The testosterone entering the sebaceous gland is converted into 5 α -dihydrotestosterone by intracellular 5 α -reductase, then is combined with steroid cells in cytoplasm, enters cell nucleus and is combined with chromatin.
2.3 diet and Nutrition
Low calorie foods can rapidly reduce sebum secretion rate, and simultaneously sebum composition changes, squalene content increases, and other components decrease. When obese people eat low calorie foods, the urine levels of DHEA and testosterone decrease. Thus, dietary changes affect sebaceous gland function, and oily and spicy foods and high-calorie foods can increase sebaceous gland secretion.
2.4 others
The secretion of sebaceous glands does not change along with the change of seasons, but the sweat on the surface of the skin is increased when the weather is hot, so that the surface tension of the skin is changed, and the sebum is more easily distributed on the face, so that the skin looks more greasy. Infrared rays and ultraviolet rays in sunlight enter hair follicles, and can directly stimulate glands to be active after contacting sebaceous glands, so that abnormal grease secretion is caused.
In addition, the moisture content of the skin surface can affect the secretory diffusion of sebum. When the skin surface has high humidity, the sebum emulsifies and diffusion becomes slow. Sebaceous glands are abnormally active when the skin is in a drier environment for a long period of time. If a part of human bodies are in a dry environment in winter, abnormal oil production and whelk frequently occur.
Regulation of oil secretion
3.1 Conditioning of sebaceous glands
When the sebaceous glands are overactive, in addition to the appearance of large pores, a purely oily skin can also cause other common skin problems, such as acne and seborrheic dermatitis. Therefore, effective regulation of sebaceous gland secretion and good control of lipid discharge are very important for maintaining healthy neutral skin conditions.
The components of the oil control composition are in the oil control mechanism and action target.
3.2 Nicotinamide
Nicotinamide, one of the B vitamins, has high safety and stable properties, and is not easily damaged by acid, alkali or heat.
Nicotinamide can keep skin energy balance, recover cell energy, and accelerate collagen synthesis, thereby avoiding melanin transpigmentation caused by low oil content and thin cuticle of skin. Nicotinamide promotes the exfoliation of keratinocytes by accelerating the renewal of the skin, and nicotinamide promotes the synthesis of epidermal proteins, enhances the self-defense ability of the skin, and increases the moisture content of the skin.
Nicotinamide enters human body to be converted with nicotinic acid, and the nicotinic acid has the functions of expanding blood vessels and promoting blood circulation. Therefore, the nicotinamide can promote blood microcirculation of hair follicles, regulate oil secretion and realize water-oil balance.
3.3 inositol
Inositol, alternative name of chinese: inositol; (ii) inositol; fibrol (inositol). Inositol is widely distributed in animals and plants and is a growth factor of animals and microorganisms. Was first isolated from the myocardium and liver. The inositol exists in nature in a plurality of cis-isomer and trans-isomer, and the naturally-existing isomer is cis-1, 2, 3, 5-trans-4, 6-inositol. Inositol obtained from water or acetic acid at 80 deg.C or higher is white crystal, has melting point of 253 deg.C, density of 1.752 g/cm 3(15 deg.C), sweet taste, solubility in water and acetic acid, and no optical activity.
Inositol is a component contained in breast milk, is an intracellular tissue component, and is an important physiological characteristic material. Is also an important substrate component of skin tissues and can promote skin rejuvenation. The skin elasticity is improved, the skin moisturizing capability is improved, the skin grease secretion is regulated, and the water-oil balance is realized.
3.4 Octanylglycine
Octanoyl glycine is an amphiphilic molecular structure compound synthesized by acylation of octanoic acid and glycine. Glycine is an important amino acid found in protein, and an amphiphilic structure is a molecular structure consisting of a hydrophilic group and a lipophilic group, is a natural component contained in skin, and is easily absorbed and utilized by the skin.
(1) Reestablishing skin acid barrier
Healthy skin is acidic, unhealthy skin is alkaline, and caprylyl glycine contains free hydroxyl groups and can reestablish acidic pH of the skin;
(2) inhibiting seborrheic dermatitis
The octanoyl glycine can inhibit bacterial proliferation generated by hair follicles, and the component has a good inhibiting effect on staphylococcus aureus, staphylococcus epidermidis and propionibacterium acnes associated with sebum under low concentration. Thereby reducing inflammatory factors caused by bacterial proliferation and avoiding excessive secretion of sebaceous glands caused by inflammatory stimulation, and the inhibition data are as follows:
| germs (bacteria) | Octanoyl glycine (MIC) |
| Staphylococcus aureus (PH ═ 5) | 0.025％a.m |
| Staphylococcus epidermidis (PH ═ 5) | 0.12％a.m |
| Propionibacterium acnes (PH 7) | 0.06％a.m |
(3) Inhibition of 5- α reductase
The secretion of sebaceous gland oil and fat, 5 α -reductase plays a decisive role, and the patent adopts new acyl glycine to regulate the excessive secretion of sebaceous gland oil and fat by inhibiting the activity of 5 α -reductase.
The caprylyl glycine has good effect of inhibiting the activity of 5 α -reductase, thereby avoiding the excessive secretion of grease.
3.5 Laminaria Saccharina extract
Laminaria Saccharina belongs to brown algae extract, mainly contains glucuronide, can form biological membrane with excellent moisture keeping effect with protein in skin, and is rich in Na+And K+The ions can help the skin to keep osmotic pressure balance, reduce excessive secreted oil and regulate physiological balance.
The brown algae extract contains brown algae polyphenols produced in the golgi apparatus and are transported by oligomers in the algal vesicles and then excreted from the cell secretion. These molecules have ecological regulation function and inhibit bacterial infection. Based on the fact that large seaweeds are subject to biotic or abiotic infestation, they produce secondary metabolites in order to survive. The Laminaria Saccharina extract can remarkably reduce sebum secretion by inhibiting lipase and regulating sebum flow.
The laminaria saccharina extract used in the embodiment of the invention can be purchased from the market, and the performance indexes are as follows:
3.6 Sophora sugar ester fermentation broth
The sophorose ester fermentation liquor prepared by fermenting candida, glucose and rapeseed methyl oleate has the effects of inhibiting sebum secretion, better inhibiting the proliferation of propionibacterium acnes and inhibiting the proliferation of corynebacterium conjunctivae siccus.
The sophorolipid fermentation liquor used in the embodiment of the invention can be purchased from the market, and the performance indexes are as follows:
sophorolipid extract
| Item | Index (I) |
| Appearance of the product | Is transparent |
| Colour(s) | Amber colour |
| Smell(s) | Characteristic odor |
| PH | 4-6 |
| Active content (solid content) | 54％-66％ |
Inhibiting skin flora
| Bacterial flora | Microorganisms | Minimum inhibitory concentration MIC |
| Skin(s) | Propionibacterium acnes | 0.05％ |
| Axilla region | Corynebacterium xerosis conjunctivae | 0.2％ |
The invention has the following beneficial effects:
1. the oil control composition uniClear adopts nicotinamide, inositol, caprylyl glycine, laminaria saccharina extract and sophorose ester fermentation liquor to regulate oil secretion on the basis of moisture preservation, and constructs a three-dimensional balance oil control technology aiming at the inhibition of the activities of three target points of lipase, 5 α -reductase and sebum flow regulation.
2. The oil control composition adopts nicotinamide and inositol to improve the metabolism capability of cells and effectively regulate the secretion of sebaceous glands of skin.
3. The oil control composition adopts caprylyl glycine to construct a skin acidic skin barrier, inhibit the proliferation activity of staphylococcus epidermidis and propionibacterium acnes, inhibit the activity of 5- α reductase and effectively ensure the normal secretion of skin oil by reducing inflammatory factors.
4. The oil control composition adopts the laminaria saccharina extract and the sophorolipid fermentation liquor to regulate the skin sebum flow, inhibit lipase and reduce the sebum content, thereby effectively regulating sebum secretion and balancing oil control.
Drawings
Fig. 1 is a graph of the percentage increase in skin oil content.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The group distribution of the examples and the comparative examples was as follows:
the control samples 1-5, examples 1-3 were added with 0.1% carbomer 940, 0.1% arginine, and PHL 1% respectively, and the balance was supplemented to 100% with deionized water to prepare moisturizing essence liquids for evaluation.
Taking example 1 as an example, the preparation process of the moisturizing essence is as follows:
1. the mixture ratio of the embodiment 1 is distributed, and the corresponding percentage of glycerin, propylene glycol, butanediol, amino acid, betaine, allantoin, nicotinamide, inositol and caprylyl glycine are weighed;
2. weighing carbomer 940 and arginine (wherein the mass ratio of caprylyl glycine to arginine is 1: 1);
3. adding deionized water to 99%, heating to 80-85 deg.C, stirring at 200rpm for 30 min.
4. Cooling to 45 deg.C, adding Laminaria Saccharina extract, sophorolipid extract, and 1% antiseptic PHL, stirring at 80-100rpm for 10min, and cooling to room temperature.
Efficacy evaluation
Principle of testing
The invention adopts a skin oil tester Sebumeter SM815 of German CK to evaluate the efficacy of the using effect of the oil absorption paper. The oil content test adopts a world recognized SEBUMETER method, which is based on the principle of photometry, after a special extinction adhesive tape with the thickness of 0.1mm absorbs oil on the skin of a human body, the special extinction adhesive tape becomes a semitransparent adhesive tape, the light transmission quantity of the semitransparent adhesive tape changes, the more the absorbed oil is, the greater the light transmission quantity is, and thus, the content of the skin oil can be measured. The test probe has the greatest advantages of small volume and convenient use, and can test any part of the skin. This is an indirect measurement of the secretion of the oil glands, and the result can be used to distinguish between different skin types, making it possible to accurately understand the changes in oil caused by internal and external causes.
Test method
The test selects 21 test objects, 3 people are divided into 7 groups, 3 areas with the size of 3cm by 3cm are drawn on the forehead respectively, skin oil content evaluation is carried out on blank samples (without wiping samples), reference samples and example samples respectively, and the average value of three people of each reference sample is calculated to carry out relevant evaluation.
(1) The selected test subjects were aged 18 to 30 years and were informed and consented to the subjects, and after the subjects cleaned their faces for 15 minutes, the fat content in the forehead was determined as an initial value.
(2) The method comprises the following steps of (1) not coating a sample on the blank area of the forehead of a subject, weighing 0.5ml of essence in a control sample area and an example sample area, soaking and covering the skin with 3cm by 3cm non-woven fabric membrane cloth for 20min, taking down the non-woven fabric, standing for 10min, respectively measuring the oil content of three areas, testing once every 30min, and continuously evaluating for 2 h;
(3) and (3) testing environment: testing the environment temperature T of 25 ℃ and the humidity H of 50;
(4) and (3) testing time: cleaning the face before testing, testing the initial oil content in 15 minutes, and testing the oil content data in 30min,60min,90min and 120min respectively;
(5) testing parts: the forehead is marked with a blank, control, test area of example.
The test results are shown in the following table.
The calculation formula is O% (O2-O1)/O1 × 100%
Note: o% is the increment of the oil content;
o1 is the initial oil content;
o2 is the evaluation of oil content.
And (4) conclusion:
the oil secretion regulating component is developed on the basis of basic moisture preservation, the oil content is evaluated through the embodiment sample and the comparison samples 1-5, and test data fully prove that the embodiment sample can effectively reduce the oil content of the skin and regulate the oil secretion.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the patent of the invention is subject to the appended claims.
Claims (7)
1. The oil control composition is characterized by comprising the following components in parts by weight:
2. the oil control composition of claim 1, comprising the following components in parts by weight:
3. an oil control composition according to any one of claims 1-2, comprising the following components in parts by weight:
4. the oil control composition of any one of claims 1-2, wherein the sophorolipid fermentation broth has an active content of 54-66%.
5. Use of an oil control composition according to any one of claims 1 to 4 in cosmetics.
6. The use according to claim 5, characterized in that the cosmetic product comprises a face wash, a lotion, a cream, a serum, a cream, a mask or a makeup.
7. A cosmetic comprising the oil control composition of any one of claims 1 to 4.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107951823A (en) * | 2017-12-06 | 2018-04-24 | 懿奈(上海)生物科技有限公司 | It is a kind of that there is the composition of oil-control and its application |
| CN108478518A (en) * | 2018-03-28 | 2018-09-04 | 湖南御家化妆品制造有限公司 | A kind of composition and the acne-eliminating cosmetic containing the composition |
| CN109431912B (en) * | 2018-12-27 | 2019-12-31 | 湖南御家化妆品制造有限公司 | Skin oil balancing composition and application thereof |
| CN111763630A (en) * | 2019-03-27 | 2020-10-13 | 深圳微健康基因科技有限公司 | Staphylococcus epidermidis and application thereof |
| CN109966237A (en) * | 2019-04-30 | 2019-07-05 | 广州蜜妆生物科技有限公司 | A kind of intelligence adjusts the composition of skin oil-water balance |
| CN110123736A (en) * | 2019-06-27 | 2019-08-16 | 湖南御家化妆品制造有限公司 | Composition and its application in the personal-care supplies of preparation oil-control moisturizing |
| CN112120985A (en) * | 2020-10-22 | 2020-12-25 | 广州科盈化妆品有限公司 | Oil-control facial cleanser and preparation method thereof |
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| FR3203M (en) * | 1964-01-30 | 1965-03-22 | Carl Joachim Kleinwichs | Antiseptic hair dye, especially for the treatment of scalp conditions. |
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| FR3203E (en) * | 1902-06-04 | 1904-09-30 | Jules Lafaurie | Stenography machine |
| CN104922056A (en) * | 2015-05-29 | 2015-09-23 | 台山美环健芦荟制品有限公司 | Fresh aloe juice gel, as well as preparation method and application thereof |
| CN105125470A (en) * | 2015-10-14 | 2015-12-09 | 吴颖斯 | Hydrogel microcapsule for oil control and acne removal |
| CN105640804A (en) * | 2016-03-21 | 2016-06-08 | 浙江大学 | Skin care product containing sea buckthorn oil and hyaluronic acid |
| CN106265264A (en) * | 2016-08-26 | 2017-01-04 | 珀莱雅化妆品股份有限公司 | A kind of acne-removing composition and preparation method thereof |
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Address after: 410000 No. 390, Guyuan Road, Changsha hi tech Development Zone, Changsha City, Hunan Province Patentee after: Shuiyang Cosmetics Manufacturing Co.,Ltd. Address before: No. 668, Qingshan Road, Changsha hi tech Development Zone, Changsha City, Hunan Province, 410205 Patentee before: HUNAN YUJIA COSMETICS MANUFACTURING Co.,Ltd. |
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