CN108261376A - A kind of three-dimensional moisturizing factor - Google Patents
A kind of three-dimensional moisturizing factor Download PDFInfo
- Publication number
- CN108261376A CN108261376A CN201810181620.8A CN201810181620A CN108261376A CN 108261376 A CN108261376 A CN 108261376A CN 201810181620 A CN201810181620 A CN 201810181620A CN 108261376 A CN108261376 A CN 108261376A
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- CN
- China
- Prior art keywords
- malt
- moisturizing factor
- powder
- dimensional moisturizing
- dimensional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 24
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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Abstract
The present invention relates to daily chemical product fields, and in particular to a kind of three-dimensional moisturizing factor.The three-dimensional moisturizing factor, in parts by weight, including carbohydrate isomer 30, Ectoin 5~12, malt extract 1~5,0.1~1.5,1,2 hexylene glycol 0.1~0.4 of decoyl hydroximic acid, polyglutamic acid sodium 0.1~0.5, hyaluronic acid 0.01~0.5, Sodium Hyaluronate 0.01~0.1, water 68~80.
Description
Technical field
The present invention relates to daily chemical product fields, and in particular to a kind of three-dimensional moisturizing factor.
Background technology
The development in epoch now and the innovation progress of technology, quickly grow cosmetic industry, while people produce beauty
Product require also to be continuously improved, and the cosmetic product of various functions, dosage form and unique look attracts the eyeball of consumption.Cosmetics be with
Smearing, sprinkling or other similar methods, impose on any position of human body surface (such as skin, nail, lip, oral cavity etc.), with
Reach cleaning, the product for eliminating the purpose of bad smell, skin care, beauty and modification.When air themperature reduces, keratoderma
Enough moisturizing factors cannot be adjusted in time, and the liveness of grease gland declines, and grease, moisture decline on the face, and skin will appear tightly
Taut phenomenon or even below eyes and microgroove occurs in nose.Skin contained humidity accounts for the 18%~20% of whole body, skin
Moisture focuses primarily upon skin corium, and under normal circumstances, the water content of women's cuticula accounts for about more than the 20% of skin, remaining
Skin corium.Water content of stratum corneum height determines its skin sense and gloss etc., but the water content of skin corium is to provide water content of stratum corneum
Reliable sources, the two is inseparable.When water content of stratum corneum is relatively low, it is possible to be converted into dry skin.And dry skin meeting
Occur pachylosis, scurf increase, angleplied laminate thinning, a series of problems, such as antianaphylaxis of skin is weak, microgroove increases.
With the development of cosmetics industry, natural plant kind product is due to the use of safety, action temperature and with obvious effects
The advantages that and welcome.The plant extracts containing active ingredient is obtained, and be added to makeup generally by corresponding processing
In product.In addition, moisturizing class cosmetics there is a need for being able to reach the rapid function to skin moisturizing and exclusive clearly moist skin
Sense.At present, product on the market, in order to increase the moisture-keeping functions of such cosmetics, add a large amount of hygroscopic agents such as hyalomitome acids,
Biofermentation polysaccharide etc., however as usage amount is excessive, skin sense can be caused greasy clouding, usage amount is low, then moistening effect is not
Significantly, with common pure water it makes no odds.Moreover, moisture-keeping cosmetics on the market easily cause allergy, easily mouldy at present
Rotten, phenomena such as stability is poor.Therefore, which kind of plant is selected, and being applied in cosmetics for its safety is reached into better guarantor
Wet effect, is a problem to be solved.
Invention content
In order to solve the above-mentioned technical problem, the first aspect of the present invention provides a kind of three-dimensional moisturizing factor, the three-dimensional
Moisturizing factor, in parts by weight, including carbohydrate isomer 30, Ectoin 5~12, malt extract 1~5, decoyl hydroxyl
Oxime acid 0.1~1.5,1,2 hexylene glycols 0.1~0.4, polyglutamic acid sodium 0.1~0.5, hyaluronic acid 0.01~0.2, hyaluronic acid
Sodium 0.01~0.1, water 68~80.
As a kind of perferred technical scheme, the three-dimensional moisturizing factor, in parts by weight, including carbohydrate isomer
30th, Ectoin 8, malt extract 2,0.64,1,2 hexylene glycol 0.16 of decoyl hydroximic acid, polyglutamic acid sodium 0.2, hyaluronic acid
0.05th, Sodium Hyaluronate 0.02, water 75.
As a kind of perferred technical scheme, the preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：1.5~3.5 weight ratio is mixed to get the malt extract.
As a kind of perferred technical scheme, the weight of the malt to germinate 2 days in the malt accounts for total malt weight
30%~40%.
As a kind of perferred technical scheme, the weight ratio of B powder and A powder is 1 in the malt extract：2.8.
As a kind of perferred technical scheme, the auxiliary agent is glycerine and/or tetrahydrochysene pipering.
The second aspect of the invention provides the application of three-dimensional moisturizing factor as described above, is led applied to skin care item
Domain.
The third aspect of the invention provides a kind of skin care item, the skin care item include three-dimensional moisturizing as described above because
Son.
The fourth aspect of the invention provides the malt extract that a kind of preparation method as described above is prepared.
The fifth aspect of the invention provides a kind of malt extract as described above and has whitening and/or guarantor in preparation
Application in the skin care item of wet effect.
Advantageous effect：It is environment friendly and pollution-free that three-dimensional moisturizing factor provided by the invention prepares raw material, non-stimulated to human skin
And allergy.In addition, the three-dimensional moisturizing factor that the application provides has very light replenishing water and preserving moisture ability, institute can not only be supplemented for skin
The moisture needed, while can also lock moisture avoids it from scattering and disappearing, keeps moistening, clearly for skin, is skin more rich in bullet
Property.Moreover, the three-dimensional moisturizing factor of the application offer also good stability while with strong moisturizing ability, wherein
Component there is included bacteriostasis property, be not required to add additional preservative and also can guarantee product preservation steady in a long-term.
Specific embodiment
The detailed description for preferred implementation method of the invention below of participating in the election of and including embodiment this hair can be more easily understood
Bright content.Unless otherwise defined, all technologies used herein and scientific terminology have common with fields of the present invention
The normally understood identical meaning of technical staff.When there is a conflict, the definition in this specification shall prevail.
As used herein term " by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " comprising ",
" having ", " containing " or its any other deformation, it is intended that cover including for non-exclusionism.For example, the combination comprising listed elements
Object, step, method, product or device are not necessarily limited to those elements, but can include not expressly listed other elements or
Such composition, step, method, product or the intrinsic element of device.
Conjunction " Consists of " excludes any element do not pointed out, step or component.If in claim, this
Phrase will make claim be closed, it be made not include the material in addition to the material of those descriptions, but relative normal
Except rule impurity.When being rather than immediately following after theme in the clause that phrase " Consists of " appears in claim main body,
It is only limited to the element described in the clause；Other elements are not excluded except the claim as a whole.
Equivalent, concentration or other values or parameter are excellent with range, preferred scope or a series of upper limit preferred values and lower limit
During the Range Representation that choosing value limits, this, which should be understood as, specifically discloses by any range limit or preferred value and any range
All ranges that any pairing of lower limit or preferred value is formed, regardless of whether the range separately discloses.For example, when open
During range " 1 to 5 ", described range should be interpreted as including range " 1 to 4 ", " 1 to 3 ", " 1 to 2 ", " 1 to 2 and 4 to
5 ", " 1 to 3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise range intention includes its end
Value and all integers and score in the range.
Singulative includes plural number and object is discussed, unless the context clearly dictates otherwise." optional " or it is " arbitrary
It is a kind of " refer to that the item described thereafter or event may or may not occur, and the description include situation that event occurs and
The situation that event does not occur.
Approximate term in specification and claims is used for modifying quantity, represents specific the present invention is not limited to this
Quantity further includes the modified part of the acceptable change without lead to related basic function close to the quantity.Phase
It answers, modifies a numerical value with " about ", " about " etc., mean that the present invention is not limited to the exact numericals.In some examples, it is approximate
Term likely corresponds to the precision of the instrument of measured value.In present specification and claims, range limits can be with
It combines and/or exchanges, these ranges include all subranges contained therebetween if not stated otherwise.
In addition, indefinite article " one kind " before element of the present invention or component and "one" quantitative requirement to element or component
(i.e. occurrence number) unrestriction.Therefore "one" or " one kind " should be read as including one or at least one, and odd number
The element or component of form also include plural form, unless the apparent purport of the quantity refers to singulative.
In order to solve the above-mentioned technical problem the first aspect of the present invention provides a kind of three-dimensional moisturizing factor, three maintenance
The wet factor, in parts by weight, including carbohydrate isomer 30, Ectoin 5~12, malt extract 1~5, decoyl hydroxyl oxime
Sour 0.1~1.5,1,2 hexylene glycols 0.1~0.4, polyglutamic acid sodium 0.1~0.5, hyaluronic acid 0.01~0.2, Sodium Hyaluronate
0.01~0.1, water 68~80.
In a preferred embodiment, the three-dimensional moisturizing factor, in parts by weight, including carbohydrate isomer
30th, Ectoin 8, malt extract 2,0.64,1,2 hexylene glycol 0.16 of decoyl hydroximic acid, polyglutamic acid sodium 0.2, hyaluronic acid
0.05th, Sodium Hyaluronate 0.02, water 75.
Carbohydrate isomer (saccharide isomerate) in the present invention is colourless or micro- yellow transparency liquid, one
Kind extraction contains the chemical composition similar to skin constituents, such as glucose, fruit from the carbohydrate of sugarcane carbohydrate synthesis
Sugar, lactose, lactose product, mannose, galactolipin, psicose etc..
Carbohydrate isomer has and the similar composition structure of human keratinous layer, assists the angle in moisture combined with stratum corneum
Albumen is a kind of good water-retaining agent and emollients to reach moistening effect, has and repair epidermal layer cells, promote skin moisturizing
Ability.Such as isomerization D- glucans are firmly tied using can be combined on the skin with epsilon-amino acid functional group just as magnetite
It closes, it can the long-acting hydromagnetic field energy power for maintaining skin.Carbohydrate isomer in the present invention can be from buying, preferably on the market
Selecting has moistening effect significantly Holland DSM chemistry carbohydrate isomers, trade name PENTAVITIN.
Ectoin chemical name is 2- methyl-1s, 4,5,6- tetrahydropyrimidine -4- carboxylic acids, due to its unique three-dimensional molecular knot
Structure, Ectoin have good hydrone complexing power, and four, five hydrones, Er Qie can be complexed in a molecule Ectoin
The lower free water structuring that can make in Skin Cell of other components interaction provided with the application, persistently improves skin moisture-keeping
The ability of water holding.In addition, Ectoin is conducive to equilibrium osmotic pressure, high halophagia bacterium in skin etc. is avoided under hypersaline environment
Dehydration is dead.Secondly, Ectoin can be promoted effectively in the case where acting synergistically with components such as carbohydrate isomer, hyaluronic acids
The immune protection ability of Skin Cell increases cell repair ability, allows the skin to effectively antagonize the invasion of microorganism and anaphylactogen,
Alleviate the various injuries suffered by skin, such as skin aging caused by ultraviolet injury, dry environment, skin caused by surfactant
Skin deterioration etc..Ectoin purchase in the present invention is in the Merck Chemical Engineering Technology Co., Ltd of Germany.
Decoyl hydroximic acid and 1 in the present invention, 2 hexylene glycols have good increase-volume hydrotropy and whitening effect, buy from moral
Merck Chemical Engineering Technology Co., Ltd of state.Polyglutamic acid sodium is the sodium salt of polyglutamic acid, and polyglutamic acid is also known as natto gum, more polyglutamics
Acid is a kind of water-soluble, biodegradable, without toxicity boiomacromolecule.Due to officials such as imino group, the carboxyls in its structure
Energy group and special molecular structure act synergistically with components such as hyaluronic acid, Sodium Hyaluronate, Ectoins, play very strong
Water suction moisturizing the effect of, make skin become water it is tender smooth, full of elasticity, promote the health of skin.Hyaluronic acid is a kind of acid
Property mucopolysaccharide, also known as sodium hyaluronate, the higher polysaccharides being made of unit D-Glucose aldehydic acid and N-acetyl-glucosamine.D-Glucose
It is connected between aldehydic acid and N-acetyl-glucosamine by β -1,3- glycosidic inkages, is connected between dissacharide units by β-Isosorbide-5-Nitrae-glycosidic inkage.It is transparent
Matter acid is one of main matrix ingredient of application on human skin epidermis and corium, moisture can be made to enter space between cells, and combined with protein
And protein gel is formed, cell is sticked together, the cell metabolism effect brought into normal play plays keeping cell moisture, and protection is thin
Born of the same parents are not encroached on by pathogen, accelerate to restore skin histology, skin are made to restore original smooth with elastic, raising Wound healing is again
The effects that raw ability, reduction scar, strengthen immunity.
It has been found that although hyaluronic acid water suction moisturizing is very capable, addition is easy in skin care item
It is mouldy under the action of harmful bacteria in environment, go bad, seriously affect stability and the shelf-life of skin care item.Moreover, applicant is also
It was found that although the components water absorbing capacity such as polyglutamic acid sodium, carbohydrate isomer, hyaluronic acid is very strong, skin water can be made tender,
With elasticity, but the moisture that these components are absorbed can be lost in, especially with these component metabolic exhaustion skin again
The water shortage that can become, tarnishes.
The preparation side that malt extract in the present invention is provided for the fructus hordei germinatus of barley seed germination gained according to the application
The product of method extraction gained.Mainly contained in barley malt protein, fat, starch, amino acid, reducing sugar, beta glucan,
The ingredients such as the sour element such as soluble (insoluble) dietary fiber, vitamin, iron, phosphorus, calcium.Contain more albumen in barley seed
Matter, starch etc. are nitrogenous, the larger molecular organics of carbon etc., and these organic matters are in enzyme classes etc. in barley seed germination process
The lower ingredients such as the low molecular peptides of generation, amino acid, sugar that decompose or degrade of effect, and these are utilized for the hair of seed into branch
Bud provides nutriment.Therefore in barley seed, the moment carries out the decomposition of each original ingredient, new chemistry in germination process
The effects that generation and consumption of ingredient, therefore the selected time requirement come the malt raw material that extracts to germination in the present invention
It is high.
In a preferred embodiment, the preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：1.5~3.5 weight ratio is mixed to get the malt extract.
It has been found that when selecting the too short malt of germinating time, the wherein macromolecular components such as protein, fat are in the majority,
It decomposes and the obtained active ingredient of degradation is on the low side, and select the too long of malt of germinating time then macromolecular components are on the low side, Er Qie
Extracting the ingredients such as hordenine, candicine in the extract of gained can also increase accordingly, improve water suction moisture-retaining capacity
Stimulation may also can be generated to skin, toxic side effect is generated to skin simultaneously.Since barley seed structure and wheat, oat etc. have
It is distinguished, the structures such as embryo therein, endosperm are also different, lead to the chemical composition contained in barley seed and germinateing
The ingredients such as the new amino acid that generates in the process, carbohydrate also have has any different with other cereals, therefore is germinateed using different cereals
The extract component that extracts of seed and effect have any different with ingredient provided herein.And select germinating time different
Effect of the malt extract that extracts of fructus hordei germinatus played in moisturizing factor also make a big difference.Using germination 2
The mixing malt of it and germination 6 days absorbs water best with water lock and other effects for the extract that raw material extracts.
In a preferred embodiment, the weight of the malt to germinate 2 days in the malt accounts for total malt weight
30%~40%.
In a preferred embodiment, the weight ratio of B powder and A powder is 1 in the malt extract：2.8.
Applicant further found that provided according to the malt extract that the method that the application provides is extracted with the application three
The other ingredient compoundings of moisturizing factor are tieed up, the ability of its replenishing water and preserving moisture can not only be improved, moreover it is possible to improve the stabilization of three-dimensional moisturizing factor
Property, even if adding the ingredients such as appropriate mouldy hyaluronic acid apt to deteriorate wherein, the guarantor of three-dimensional moisturizing factor will not be influenced
The matter phase.In actual production, in order to improve the water absorbing capacity of such moisturizer, need to add some bibulous ingredients, but
It is that the additions of these ingredients often causes other unfavorable effects, such as improve product water imbibition while easily becomes product
It is unstable, easy moldy metamorphism etc..And the biocidal property of three-dimensional moisturizing factor that the application provides can solve this problem.
The three-dimensional moisturizing factor that the application provides, which has the possible cause of biocidal property, to be prepared by the method that the application provides
In malt extract containing some antipathogenic compositions, the increment of harmful bacteria is inhibited to break up or contain in malt extract
The compound of partial hydrophilicity macromolecular structure, film forming ability is strong, and three-dimensional moisturizing factor absorbs water the same of moisturizing in use
When, the absorbing membrane of three-dimensional network state can be also formed, maintains moisture, it is avoided to scatter and disappear, while from also coating hyaluronic acid etc.
The ingredient of harmful bacteria is easily grown, avoids its moldy metamorphism, stability is improved, extends the shelf life.
In a preferred embodiment, the auxiliary agent is glycerine and/or tetrahydrochysene pipering.Auxiliary agent in the present invention with
Microwave interactive promotes infiltration of the solvent toward cell inside malt, improves the dissolution of active ingredient in malt.When auxiliary agent is sweet
There is no particular/special requirement to its weight ratio when oil and tetrahydrochysene fagarine, wherein tetrahydrochysene fagarine can be bought from Nanjing Dao Sifusheng
Object Science and Technology Ltd..
The second aspect of the invention provides answering for the three-dimensional moisturizing factor as described in claim 1~6 any one
With applied to skin care field.
The third aspect of the invention provides a kind of skin care item, and the skin care item are included as claim 1~6 is any one
Three-dimensional moisturizing factor described in.
The fourth aspect of the invention provides the malt that a kind of preparation method as claimed in claim 4 is prepared and carries
Take object.
The fifth aspect of the invention provides a kind of malt extract as claimed in claim 9 and has whitening in preparation
And/or the application in the skin care item of moisture-keeping efficacy.
In the present invention, the skin care item can be various forms well known by persons skilled in the art cosmetics, comprising and
It is not limited to aqua, lotion, face cream, eye cream, mildy wash, facial mask, BB frosts, consummate liquid, suncream, sun water, acne water, acne
Dew, face cleaning water, face cleaning dew, essential oil, shampoo, moisture retention water, toner, astringent lotion, smoothing toner.The lotion, face cream are liquid frost
Class cosmetics.The mildy wash, face cleaning water, face cleaning dew refer generally to by oil phase thing, aqueous-phase material, surfactant, moisturizer, nutrition
The liquiform product that the ingredients such as agent are formed, including but not limited to facial cleanser, face cleaning cream, clean skin liquid.The facial mask is face beautifying health keeping product
A kind of carrier, including but not limited to mud cream type, tear-pull, gel-type, hygenic towelette type facial mask.The BB frosts refer to Blemish
Balm, effect include but not limited to hide the flaw, adjust the colour of skin, is sun-proof, careful pore.The consummate liquid refers to the high nutrition for including concentration
The forms such as substance, including but not limited to Essence, essence dew, essence facial mask, essence hormone injection, " Jinghuasu " essence capsule.It is described sun-proof
Frost for be added to can obstruct or absorb the sun-screening agent of ultraviolet light reach prevent skin by it is tanned, sunburn cosmetics.The Cuo
Sore water is the liquid for having effects that treat acne.The lotion for pimples is the liquid for having the function of to treat acne.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following embodiment is only used
In the invention will be further described, it is impossible to be interpreted as limiting the scope of the invention, professional and technical personnel in the field
Some the nonessential modifications and adaptations made according to the content of the invention described above, still fall within protection scope of the present invention.
If raw materials used to be all commercially available in addition, without other explanations, it is purchased from traditional Chinese medicines chemical reagent.
Embodiment
Embodiment 1
Embodiment 1 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 5, malt extract 1, decoyl hydroximic acid 0.1,1,2 hexylene glycols 0.1, polyglutamic acid sodium 0.1, thoroughly
Bright matter acid 0.01, Sodium Hyaluronate 0.01, water 68.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：1.5 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 30% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market, then and originally
The three-dimensional moisturizing factor that example provides is combined with use.Specifically used method is to take 3 parts of cosmetics bought on the market and 0.5 part
Use after the three-dimensional moisturizing factor mixing that this example provides.
Embodiment 2
Embodiment 2 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 12, malt extract 5, decoyl hydroximic acid 1.5,1,2 hexylene glycols 0.4, polyglutamic acid sodium 0.5, thoroughly
Bright matter acid 0.2, Sodium Hyaluronate 0.5, water 80.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：3.5 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 40% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market, then and originally
The three-dimensional moisturizing factor that example provides is combined with use.Specifically used method is to take 3 parts of cosmetics bought on the market and 0.5 part
Use after the three-dimensional moisturizing factor mixing that this example provides.
Embodiment 3
Embodiment 3 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market, then and originally
The three-dimensional moisturizing factor that example provides is combined with use.Specifically used method is to take 3 parts of cosmetics bought on the market and 0.5 part
Use after the three-dimensional moisturizing factor mixing that this example provides.
Embodiment 4
Embodiment 4 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
The auxiliary agent is tetrahydrochysene pipering；The weight of the malt to germinate 2 days in the malt accounts for total malt weight
38%.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market, then and originally
The three-dimensional moisturizing factor that example provides is combined with use.Specifically used method is to take 3 parts of cosmetics bought on the market and 0.5 part
Use after the three-dimensional moisturizing factor mixing that this example provides.
Comparative example 1
Comparative example 1 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.5, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market, then and originally
The three-dimensional moisturizing factor that example provides is combined with use.Specifically used method is to take 3 parts of cosmetics bought on the market and 0.5 part
Use after the three-dimensional moisturizing factor mixing that this example provides.
Comparative example 2
Comparative example 2 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2, hyaluronic acid 0.05,
Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 1
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 3
Comparative example 3 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the addition 70wt% ethyl alcohol of 60ml and 2g auxiliary agents (glycerine) in the filter residue of (2) step filtering gained, and
Filtrate is collected in Microwave Extraction 45min under 480W power, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 1
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 4
Comparative example 4 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the addition 70wt% ethyl alcohol of 60ml and 2g auxiliary agents (glycerine) in the filter residue of (2) step filtering gained, and
Filtrate is collected in Microwave Extraction 45min under 480W power, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 3
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 5
Comparative example 5 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 3
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 6
Comparative example 6 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：0.5 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 3
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 7
Comparative example 7 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate, concentrate, and drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and in 480W power in the filter residue of (2) step filtering gained
Filtrate is collected in lower Microwave Extraction 45min, filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 3
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 8
Comparative example 8 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) it adds in the 25wt% ethyl alcohol of 60ml in the filter residue of (2) step filtering gained and 2g auxiliary agents, refluxing extraction 2 is small
When, filtrate is collected in filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 3
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 9
Comparative example 9 provides a kind of three-dimensional moisturizing factor, and the three-dimensional moisturizing factor is in parts by weight, same including carbohydrate
Enantiomers 30, Ectoin 8, malt extract 2, decoyl hydroximic acid 0.64,1,2 hexylene glycols 0.16, polyglutamic acid sodium 0.2,
Hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
The preparation method of the malt extract includes the following steps：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 are ultrasonically treated after being stirred
Minute, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titanium dioxide powders are added in gained filtrate
End, and filtered after being irradiated 15 seconds under low pressure mercury lamp, filtrate is collected, is concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml is added in the filter residue of (2) step filtering gained, and microwave carries under 480W power
45min is taken, is filtered, collects filtrate, is concentrated, drying obtains B powder；
(4) B powder and A powder are with 1：2.8 weight ratio is mixed to get the malt extract.
The auxiliary agent is glycerine；The weight of the malt to germinate 2 days in the malt accounts for the 38% of total malt weight.
This example also provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with embodiment 3
It is identical), the three-dimensional moisturizing factor then provided with this example is combined with use.Specifically used method is to take 3 parts to buy on the market
Use after cosmetics are mixed with the three-dimensional moisturizing factor that 0.5 part of this example provides.
Comparative example 10
Comparative example 10 provides a kind of skin care item, and the skin care item are a cosmetics arbitrarily bought on the market (with reality
It is identical to apply example 3).
Performance evaluation
1. performance of keeping humidity is tested
Due to the difference between the dielectric constant of other substances on water and human body's skin, lead to the flesh of different in moisture content
Skin capacitance is different, therefore the relative amount of moisture in skin can be understood by capacitance method.Specifically test method is：Each
Same amount of the embodiment of the present application and comparative example are smeared in the identical position of the clean inboard arm of subject and identical region
The three-dimensional moisturizing factor of offer, test period, during which subject did not used other any cosmetics within 48 hours.Then it uses
The skinanalysis apparatus of German CK models test respectively smear moisturizing factor after 2 hours and 48 hours when subject's skin
The moisture content value of cuticula.Each sample randomly selects the volunteer 10 of 22~40 years old, takes the average value of test result.Institute
For the moisture test value stated between 0~150, numerical value is higher to represent that moisture content in skin is more.
1 performance of keeping humidity of table tests table
| 2 one hour values | 48 one hour values | |
| Embodiment 1 | 113.2 | 57.7 |
| Embodiment 2 | 115.8 | 62.5 |
| Embodiment 3 | 124.1 | 81.9 |
| Embodiment 4 | 122.6 | 77.2 |
| Comparative example 1 | 139.4 | 39.0 |
| Comparative example 2 | 80.0 | 26.4 |
| Comparative example 3 | 88.5 | 42.5 |
| Comparative example 4 | 119.3 | 51.3 |
| Comparative example 5 | 107.2 | 45.0 |
| Comparative example 6 | 83.1 | 40.7 |
| Comparative example 7 | 85.0 | 37.4 |
| Comparative example 8 | 106.6 | 41.6 |
| Comparative example 9 | 103.3 | 41.3 |
2. stability test
(1) the three-dimensional moisturizing factor of the embodiment of the present application and comparative example offer is tested to staphylococcus aureus and large intestine bar
The inhibiting rate of bacterium.Concrete operation method is：1g above-described embodiments and the three-dimensional moisturizing factor of comparative example offer are provided, add in 20ml's
Three-dimensional moisturizing factor solution is obtained after 50wt% ethanol solutions after stirring and dissolving, is preserved with spare.
For trying the preparation of bacterial suspension：By Escherichia coli and S. aureus Inoculate in Tube propagation base,
The distilled water of aseptic process is added in after being cultivated 48 hours at 37 DEG C in insulating box, concussion obtains experimental bacteria suspension.15ml is taken to melt
The SOB culture mediums of change, are placed in sterilizing plates, 1ml experimental strains are then added dropwise respectively, and it is made to pave plate bottom.It treats
After culture medium solidification, 4 Oxford cups are stood up on each tablet, 0.1ml three-dimensional moisturizing factor solution are then respectively adding, 37
DEG C culture measures the size (unit of antibacterial circle diameter respectively after 24 hours：mm).
(2) high-temperature stability：5g above-described embodiments and the skin care item (paste skin care item) of comparative example offer are provided, are placed in identical
Culture dish is placed in insulating box at 40 DEG C to preserve to take out after a week in the culture dish of dimensions, after striking off and observes the skin care item
Whether there are thinning, discoloration, layering, dehydration the apparent deterioration such as are hardened, are mouldy.
2 stability test result of table
3. use skin sensing examination
22~40 years old subject is randomly selected, the skin care item provided the embodiment of the present application and comparative example carry out skin sensing
Examination.Specific practice is：For 50 people of each sample using the skin care item, usage time is every morning 9：30~10：00 and afternoon 16：
30~17：00, persistently using surrounding, during this period without using other any cosmetics, record subject skin quality variation.
Skin is without there is the feature of the allergy such as stimulation, itch, erythema after the skin care item that subject is provided using the application.
Table 3 senses test result using skin
| The apparent neatly of skin | Skin slightly improves | Improve unobvious | |
| Embodiment 1 | 45 | 5 | 0 |
| Embodiment 2 | 46 | 4 | 0 |
| Embodiment 3 | 49 | 1 | 0 |
| Embodiment 4 | 49 | 1 | 0 |
| Comparative example 1 | 37 | 12 | 1 |
| Comparative example 2 | 33 | 15 | 2 |
| Comparative example 3 | 39 | 10 | 1 |
| Comparative example 4 | 40 | 10 | 0 |
| Comparative example 5 | 40 | 9 | 1 |
| Comparative example 6 | 39 | 10 | 1 |
| Comparative example 7 | 40 | 10 | 0 |
| Comparative example 8 | 38 | 10 | 2 |
| Comparative example 9 | 43 | 7 | 0 |
| Comparative example 10 | 27 | 15 | 8 |
By above table it can be seen that the three-dimensional moisturizing factor that the application provides has very strong replenishing water and preserving moisture characteristic.It protects
The moisture content of skin that the wet factor is smeared and reached when water suction aproll basically reaches balance (after smearing 2 hours or so) is very high, and
Still most moisture can be kept not scattered and disappeared after smearing primary wait for 48 hours.In addition the application provide three-dimensional moisturizing because
While son has very strong replenishing water and preserving moisture performance, also have a degree of bacteriostasis property, do not needed to when being used in cosmetics
Additional preservative can also be preserved and be never degenerated for a long time.Moreover, the three-dimensional moisturizing factor that the application provides has good skin sense
Experience, does not generate skin stimulation or allergy, makes skin refreshing, flexible etc..
Aforementioned example is merely illustrative, for explaining some features of the method for the invention.Appended right will
It asks and is intended to the range as wide as possible that requirement is contemplated that, and embodiments as presented herein is only according to all possible implementation
The explanation of the embodiment of the selection of the combination of example.Therefore, the purpose of applicant is that appended claim is not illustrated this hair
The exemplary selectional restriction of bright feature.Some numberical ranges used also include sub- model in the claims
It encloses, the variation in these ranges should be also construed in the conceived case by appended claim covering.
Claims (10)
1. a kind of three-dimensional moisturizing factor, which is characterized in that the three-dimensional moisturizing factor, it is in parts by weight, different with dividing including carbohydrate
Structure body 30, Ectoin 5~12, malt extract 1~5,0.1~1.5,1,2 hexylene glycol 0.1~0.4 of decoyl hydroximic acid, poly- paddy
Propylhomoserin sodium 0.1~0.5, hyaluronic acid 0.01~0.2, Sodium Hyaluronate 0.01~0.1, water 68~80.
2. three-dimensional moisturizing factor as described in claim 1, which is characterized in that the three-dimensional moisturizing factor, in parts by weight, packet
Include carbohydrate isomer 30, Ectoin 8, malt extract 2,0.64,1,2 hexylene glycol 0.16 of decoyl hydroximic acid, polyglutamic
Sour sodium 0.2, hyaluronic acid 0.05, Sodium Hyaluronate 0.02, water 75.
3. three-dimensional moisturizing factor as described in claim 1, which is characterized in that the preparation method of the malt extract is included such as
Lower step：
(1) it is raw material to choose the malt to germinate 2 days and 6 days, is crushed；
(2) malt of 10g crushing is weighed, and wherein adds in the 25wt% ethyl alcohol of 120ml, 10 points are ultrasonically treated after being stirred
Clock, then stirring extraction 3 hours at 75 DEG C, are collected by filtration filtrate；0.03g titania powders are added in gained filtrate,
And it is filtered after being irradiated 15 seconds under low pressure mercury lamp, collects filtrate, concentrated, drying obtains A powder；
(3) the 70wt% ethyl alcohol of 60ml and 2g auxiliary agents are added in, and micro- under 480W power in the filter residue of (2) step filtering gained
Wave extracts 45min, and filtrate is collected in filtering, is concentrated, and drying obtains B powder；
(4) B powder and A powder are with 1：1.5~3.5 weight ratio is mixed to get the malt extract.
4. three-dimensional moisturizing factor as claimed in claim 3, which is characterized in that the weight of the malt to germinate 2 days in the malt
Account for the 30%~40% of total malt weight.
5. three-dimensional moisturizing factor as claimed in claim 3, which is characterized in that B powder and A powder in the malt extract
Weight ratio is 1：2.8.
6. three-dimensional moisturizing factor as claimed in claim 3, which is characterized in that the auxiliary agent is glycerine and/or tetrahydrochysene pipering.
7. the application of the three-dimensional moisturizing factor as described in claim 1~6 any one, which is characterized in that applied to skin care item
Field.
8. a kind of skin care item, which is characterized in that the skin care item include three maintenances as described in claim 1~6 any one
The wet factor.
9. a kind of malt extract that preparation method as claimed in claim 3 is prepared.
10. a kind of malt extract as claimed in claim 9 has in preparation in the skin care item of whitening and/or moisture-keeping efficacy
Using.
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| CN108685759A (en) * | 2018-07-11 | 2018-10-23 | 华熙福瑞达生物医药有限公司 | A kind of composition of hyaluronic acid substance and tetrahydropyrimidine substance |
| CN108785125A (en) * | 2018-08-23 | 2018-11-13 | 广东丸美生物技术股份有限公司 | Has effects that moisturizing and the organic skin care matrix that highlights and preparation method thereof, cosmetic composition and application |
| CN109846748A (en) * | 2018-11-02 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of moisturiser containing black phycocolloid and preparation method thereof, application |
| CN109953902A (en) * | 2019-03-27 | 2019-07-02 | 山东智医智药生物科技有限公司 | A kind of maintenance process of the skin of face of non-treatment purpose |
| CN110812250A (en) * | 2019-11-12 | 2020-02-21 | 华熙生物科技股份有限公司 | Facial mask capable of rapidly gelling and preparation and application methods thereof |
| CN114469823A (en) * | 2021-06-24 | 2022-05-13 | 重庆米洛诊所管理有限公司 | Novel moisturizing factor composition and preparation and application thereof |
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| CN109846748A (en) * | 2018-11-02 | 2019-06-07 | 上海珈凯生物科技有限公司 | A kind of moisturiser containing black phycocolloid and preparation method thereof, application |
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| CN109953902B (en) * | 2019-03-27 | 2022-02-22 | 山东智医智药生物科技有限公司 | A method for caring facial skin for non-therapeutic purpose |
| CN110812250A (en) * | 2019-11-12 | 2020-02-21 | 华熙生物科技股份有限公司 | Facial mask capable of rapidly gelling and preparation and application methods thereof |
| CN114469823A (en) * | 2021-06-24 | 2022-05-13 | 重庆米洛诊所管理有限公司 | Novel moisturizing factor composition and preparation and application thereof |
| CN114469823B (en) * | 2021-06-24 | 2024-02-23 | 重庆米洛诊所管理有限公司 | Novel moisturizing factor composition and preparation and application thereof |
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