CN110302081A - A kind of dual sodium hyaluronate stoste and preparation method thereof - Google Patents
A kind of dual sodium hyaluronate stoste and preparation method thereof Download PDFInfo
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- CN110302081A CN110302081A CN201910690856.9A CN201910690856A CN110302081A CN 110302081 A CN110302081 A CN 110302081A CN 201910690856 A CN201910690856 A CN 201910690856A CN 110302081 A CN110302081 A CN 110302081A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to cosmetic technical fields, disclose a kind of dual sodium hyaluronate stoste and preparation method thereof, raw material components including following weight percent: hyaluronic acid A 0.05%~0.5%, hyaluronic acid B 0.05%~5%, transparent xanthan gum 0.01%~1%, glycerol 3%~9%, butanediol 2%~6%, oat kernel extract 0.5%~5%, avenabeta glucosan 0.5%~5%, moisturizing factor 0.5%~5%, aloe barbadensis Miller leaf juice 1%~5%, polyacrylate cross-linked polymer -6 0.1%~0.5%, essence 0.005%~0.008%, solubilizer 0.02%~0.04%, preservative 0.4%~0.6%, deionized water surplus.The breakthrough proportion by reasonably adjusting two kinds of different molecular weight hyaluronic acids of the present invention, it is set just to form thin film in skin surface, effectively lock the moisture in skin, to achieve the effect that permanent moisturizing, there is sliding sense but non-greasy simultaneously, either in cold winter still in torridity summer, usage experience is good, and cost is relatively low be easy received by public group.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of dual sodium hyaluronate stoste and preparation method thereof.
Background technique
Aqua class moisturizer because without most of oil in moisturizing persistence all existing defects, if increased simply
Moisturizer extends moistening effect, and higher cost is not easy to be accepted by the public；Although emulsifying moisturizer contains oil, moisturizing
Effect is stronger, but hot season is easy to give people's greasy feeling, and usage experience is bad.So occurring sodium hyaluronate on the market now
As preferable moisturizer.Sodium hyaluronate is also known as hyaluronic acid, is a kind of ideal natural moisturizing factor, have promote nutrition at
Divide and absorbs, improve skin-nourishing metabolism, make the tender smooth effect of skin.Sodium hyaluronate can be divided into small molecule sodium hyaluronate by molecular weight
And sub-Q, the moistening effect of small molecule sodium hyaluronate is significantly larger than sub-Q, but it is expensive, works as addition
When measuring more, production cost is excessively high, and when additive amount is too low, skin effect is again unobvious, therefore, how in control reasonable cost
Under the premise of to promote the moistening effect of sodium hyaluronate product be a problem that current cosmetic industry faces.
Summary of the invention
For deficiency present in background technique, the present invention carries out targeted design, and it is former to provide a kind of dual sodium hyaluronate
Liquid can form thin film in skin surface, effectively lock the moisture in skin, to achieve the effect that permanent moisturizing, simultaneously
With sliding sense but non-greasy, usage experience is good, and cost is relatively low.
The present invention also provides a kind of preparation method of dual sodium hyaluronate stoste, this method is easy to operate, it is easy to accomplish, at
This is cheap, can carry out scale volume production.
To achieve the above object, the invention provides the following technical scheme:
A kind of dual sodium hyaluronate stoste, the raw material components including following weight percent: hyaluronic acid A0.05%~
0.5%, hyaluronic acid B 0.05%~5%, transparent xanthan gum 0.01%~1%, glycerol 3%~9%, butanediol 2%~
6%, oat kernel extract 0.5%~5%, avenabeta glucosan 0.5%~5%, moisturizing factor 0.5%~5%, Curacao reed
Luxuriant growth leaf juice 1%~5%, polyacrylate cross-linked polymer -6 0.1%~0.5%, essence 0.005%~0.008%, solubilising
Agent 0.02%~0.04%, preservative 0.4%~0.6%, deionized water surplus.
The essence of hyaluronic acid is a kind of viscous polysaccharide, also known as sodium hyaluronate, belongs to skin conditioner, is naturally present in human body
Skin histology and connective tissue in, can absorb itself 1000 times of moisture of weight, with reach by retain moisture of skin, prevent
Moisture is lost through epidermis, and the barrier reparation when skin is damaged, and is enabled skin not feel drying after, is efficiently grabbed
Water keeps skin soft and moist glossy, is good skin penetration enhancer again while moisturizing, makes with the cooperation of other nutritional ingredients
With can play and promote nutrient absorption to more preferably effect.The hyaluronic acid of small molecule can penetrate into corium, have mild dilation
Capillary increases blood circulation, improves intermediate supersession, promotes skin-nourishing absorption, has the function of stronger wrinkle-chasing, can
Increase skin elasticity, delay skin aging, but it is expensive, higher cost；Sub-Q can be formed in skin surface
It is wet to make skin smooth, and can obstruct the intrusion of alien bacteria, dust, ultraviolet light for one layer of ventilative film, protects the skin from
Infringement, compact skin, permanent moisturizing, and sub-Q is cheap, and cost performance is high.
Transparent xanthan gum is also known as xanthan gum, is natural gum, is mainly used as thickener, emulsion stabilizer uses.Natural gum
Body do not stick it is greasy, it is soluble easily in water, and it is emulsifiable become hydrophily thick gel, as stabilizer or thickener in use, only needing
Addition can little by little increase product consistency.And also the use of approved xanthan gum is in food for U.S. FDA, therefore the ingredient is safe
Property is higher, can be safe to use.
Glycerol is also known as glycerine, with water sorption, adsorbs the hydrone in air with it in the present invention, it is enabled to cover
Keratoderma keeps wet.
Butanediol is gentle as moisturizer and solvent, can increase the smooth degree of product, no sensitization, CIR and FDA are extremely
It is all safety that the present, which assesses this ingredient,.It is used as small molecule moisturizing composition in the present invention, moisture can be stayed in cuticula, had good
Hygroscopicity, the absorbable moisture for being equivalent to quality 12.5% and 38.5% itself, while also having certain bacteriostasis.
Oat kernel extract is the natural products extracted from oat kernel, is used as antioxidant and moisturizer, is had
The effect of skin whitening, moisturizing and nursing skin.Energy growth-promoting natural collagen protein, promotes elasticity of skin, also has oxidation resistance, can
Effective delaying skin aging.
Avenabeta glucosan is present in the cell wall of oat bran, is that a kind of sugar that cellotriose is connected with cellotetrose is single
The poly- polysaccharide of body composition.The beta glucan extracted from grass family oat seed, it contains the water of the oat beta-glucan of purification
Insoluble portion is free of lipid, fiber and protein, is able to maintain the moisture of skin, and leucocyte is situated between can promote macrophage release
The acceleration of plain -1 pair of collagen synthesis, resists aging, reduces wrinkle of skin, improves skin elasticity, improves dermatoglyph,
With good Transdermal absorption performance, it can promote wound healing, the impaired skin of reparation.
Aloe barbadensis Miller leaf juice from the facilitation increased to fibrin, to the inhibition of elastin laminin, to collagen
Synthesis and scavenging effect to free radical, illustrate to have the function of good skin-active, anti-aging；There is rush to cholesterine synthesis
Into effect, facilitate the composition for changing sebum, reduces soft and moist degree that is glossy and increasing skin；There is antibacterial anti-inflammatory and guarantor simultaneously
Wet effect.
Polyacrylate cross-linked polymer -6 is a kind of high molecular polymer, is used for thickener and film forming agent in the present invention
It uses.
The measure further taken is: the hyaluronic acid A is 900,000 molecular weight, and hyaluronic acid B is 140 sub very much
Amount.
The measure further taken is: the moisturizing factor be selected from 1,2- hexylene glycol, Anjidew NL50, pungent glycol, tocopherol or
It is any one or more in lactic acid.
1,2- hexylene glycol belongs to polyalcohol, uses as moisturizer, has fungistatic effect, and additive amount has at 5% or so
There is anti-corrosion effect, but is not equal to preservative.
Anjidew NL50 is also known as pyrrolidone sodium carboxylate, makees moisturizer, skin conditioner and antistatic agent in the present invention and uses,
Be skin natural component and good moisturizer, have and strengthen cutin function, and the moisturizing energy to enhance skin itself
Power.
Pungent glycol is a good moisturizer, and has bacteria resistance function, can play the role of moisturizing, soft and moist, and reach
Mild corrosion-resistant effect.
Tocopherol, that is, vitamin E is to two kinds of chemical substances in fact: the general name of Tocopherol and triolefin Tocopherol, both
The biological effect of chemical substance in vivo is roughly the same, and only activity is different.Tocopherol has moisture-keeping efficacy and great
Antioxidant, can be to Anti-lipid peroxidation.
Lactic acid is also known as lactic acid, belongs to one kind of tartaric acid, has preferable moisture-keeping function, its irritation is compared with other tartaric acid
Irritation is small, is gentle.
Further step is: the solubilizer is selected from Cremophor RH40 and/or polysorbate -20.
Cremophor RH40 is used as solubilizer and surfactant, can more be slided after being added in the present invention
It is suitable, the oily matters such as essence can be evenly dispersed into water, form stable, transparent solution.
Polysorbate -20 belongs to fatty acid, is dissolvable in water water, does solubilizer use in the present invention, can increase production
Product smoothness.There are good solubilization, emulsification to the various grease types such as mineral oil, vegetable oil, animal fat and divides
Effect is dissipated, is mainly used as manufacture liquid preparation in the present invention.
Further, the preservative is selected from Phenoxyethanol and/or methyl hydroxybenzoate.
Phenoxyethanol slightly has aromatic odor, 80 DEG C or less stabilizations, and pH stablizes effectively 3~10, can be with anions and canons surface
Active ingredient.Phenoxyethanol corrosion-resistant mechanism is that the permeability of microbial film is caused to be lost, and cellular content is caused to ooze out,
Lose the energy that electronics power generates.Inhibition mainly is generated to bacterium, usually compounds the p-hydroxybenzoate of short chain, such as first
Ester, propyl ester, or polyalcohol etc., to achieve the effect that broad-spectrum antibacterial.
Preservative of the methyl hydroxybenzoate as parabens, it is stronger to the antibacterial action of yeast and mold, mainly pass through
Destroy microorganism cell membrane, make intracellular protein denaturation, and inhibit cellular respiration enzyme and transmit enzyme system activity and
Play antibacterial action.Faint ionization can occur for the H in molecule on phenolic hydroxyl group, and antibacterial action is influenced by H concentration in system,
Therefore p-hydroxybenzoate can play preferable antisepsis in the environment of slant acidity.In general, with alkyl carbon chain
The increase of length, antibacterial effect are better.
A kind of preparation method of dual sodium hyaluronate stoste, comprising the following steps:
S1: hyaluronic acid A, hyaluronic acid B and transparent xanthan gum is scattered spare in advance with glycerol respectively；
S2: deionized water and butanediol are added in emulsion pot, then by scattered hyaluronic acid A, hyaluronic acid B and thoroughly
Emulsion pot is added in Framingham raw rubber, opens heating；
S3: S2 mixture is warming up to T1DEG C stirring and dissolving, and the temperature is maintained to stir；
S4: S3 mixture is cooled to T2DEG C or less after, be added oat kernel extract, avenabeta glucosan, moisturizing factor,
Aloe barbadensis Miller leaf juice, polyacrylate cross-linked polymer -6, essence, solubilizer and preservative, stir evenly.
Specifically: T in S31It is 80~90 DEG C, optimum temperature is 85 DEG C, and the temperature is maintained to stir 15~20 points
Clock.
Specifically: T in S42It is 40~50 DEG C, optimum temperature is 45 DEG C.
Application method of the invention: it takes 2~3 drop this products to be uniformly applied to face after face cleaning, and is gently massaged into absorption
Or it is uniformly applied to face after taking 2~3 drop this products to mix with appropriate toner or lotion, and be gently massaged into absorption.
Design in this way, a kind of dual sodium hyaluronate stoste of the invention and preparation method thereof, compared with prior art,
Have it is following the utility model has the advantages that
1, the dual sodium hyaluronate stoste, the breakthrough proportion by reasonably adjusting two kinds of different molecular weight hyaluronic acids,
So that it is just formed thin film in skin surface, effectively locks the moisture in skin, to achieve the effect that permanent moisturizing, simultaneously
With sliding sense but non-greasy, either in cold winter still in torridity summer, usage experience is good, and cost is relatively low easy quilt
Public group receives.
2, the preparation method of the dual sodium hyaluronate stoste, it is easy to operate, it is easy to accomplish, it is low in cost, scale can be carried out
Volume production.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
Embodiment
A kind of dual sodium hyaluronate stoste, by weight percentage, raw material components and content are as shown in table 1 below:
The dual sodium hyaluronate stoste formula of table 1 (being formulated each raw material summation is 100%)
Embodiment through above 8 different ratios tests gained, and hyaluronic acid A i.e. 900,000 molecular weight and hyaluronic acid B are
When the weight percent of 1400000 molecular weight is 0.15%, the moistening effect of the dual sodium hyaluronate stoste is best, and it is permanent to reach
The effect of moisturizing.
The preparation method of Examples 1 to 8:
S1: hyaluronic acid A, hyaluronic acid B and transparent xanthan gum is scattered spare in advance with glycerol respectively；
S2: deionized water and butanediol are added in emulsion pot, then by scattered hyaluronic acid A, hyaluronic acid B and thoroughly
Emulsion pot is added in Framingham raw rubber, opens heating；
S3: being warming up to 85 DEG C of stirring and dissolvings for S2 mixture, and the temperature is maintained to stir 15 minutes；
S4: after S3 mixture is cooled to 45 DEG C or less, be added oat kernel extract, avenabeta glucosan, moisturizing factor,
Aloe barbadensis Miller leaf juice, polyacrylate cross-linked polymer -6, essence, solubilizer and preservative, stir evenly.
The breakthrough proportion by reasonably adjusting two kinds of different molecular weight hyaluronic acids of the present invention, makes it just in skin
Surface forms thin film, effectively locks the moisture in skin, to achieve the effect that permanent moisturizing, while having and sliding feeling but not oily
Greasy, either in cold winter still in torridity summer, usage experience is good, and cost is relatively low be easy received by public group.
The preparation method of the dual sodium hyaluronate stoste, it is easy to operate, it is easy to accomplish, it is low in cost, scale volume production can be carried out.
The above is only used to illustrate the technical scheme of the present invention and not to limit it, and those of ordinary skill in the art are to this hair
The other modifications or equivalent replacement that bright technical solution is made, as long as it does not depart from the spirit and scope of the technical scheme of the present invention,
It is intended to be within the scope of the claims of the invention.
Claims (8)
1. a kind of dual sodium hyaluronate stoste, which is characterized in that the raw material components including following weight percent: hyaluronic acid A
0.05%~0.5%, hyaluronic acid B 0.05%~5%, transparent xanthan gum 0.01%~1%, glycerol 3%~9%, butanediol
2%~6%, oat kernel extract 0.5%~5%, avenabeta glucosan 0.5%~5%, moisturizing factor 0.5%~5%, library
Drag-line aloe leaf juice 1%~5%, polyacrylate cross-linked polymer -60.1%~0.5%, essence 0.005%~0.008%,
Solubilizer 0.02%~0.04%, preservative 0.4%~0.6%, deionized water surplus.
2. a kind of dual sodium hyaluronate stoste according to claim 1, it is characterised in that: the hyaluronic acid A is 900,000
Molecular weight, hyaluronic acid B are 1,400,000 molecular weight.
3. a kind of dual sodium hyaluronate stoste according to claim 2, it is characterised in that: the moisturizing factor is selected from 1,2-
It is any one or more in hexylene glycol, Anjidew NL50, pungent glycol, tocopherol or lactic acid.
4. a kind of dual sodium hyaluronate stoste according to claim 3, it is characterised in that: the solubilizer is selected from PEG-40
Rilanit special and/or polysorbate -20.
5. a kind of dual sodium hyaluronate stoste according to claim 4, it is characterised in that: the preservative is selected from benzene oxygen second
Alcohol and/or methyl hydroxybenzoate.
6. a kind of described in any item preparation methods of dual sodium hyaluronate stoste of claim 1-5, which is characterized in that including following
Step:
S1: hyaluronic acid A, hyaluronic acid B and transparent xanthan gum is scattered spare in advance with glycerol respectively；
S2: deionized water and butanediol are added in emulsion pot, then by scattered hyaluronic acid A, hyaluronic acid B and the transparent Chinese
Emulsion pot is added in raw rubber, opens heating；
S3: S2 mixture is warming up to T1DEG C stirring and dissolving, and the temperature is maintained to stir；
S4: S3 mixture is cooled to T2DEG C or less after, be added oat kernel extract, avenabeta glucosan, moisturizing factor, Ku La
Rope aloe leaf juice, polyacrylate cross-linked polymer -6, essence, solubilizer and preservative, stir evenly.
7. a kind of preparation method of dual sodium hyaluronate stoste according to claim 6, it is characterised in that: T in S31For 80~
90 DEG C, optimum temperature is 85 DEG C, and the temperature is maintained to stir 15~20 minutes.
8. a kind of preparation method of dual sodium hyaluronate stoste according to claim 7, it is characterised in that: T in S42For 40~
50 DEG C, optimum temperature is 45 DEG C.
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Application publication date: 20191008 |
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