CN115400034A - Moisturizing and repairing essence milk and preparation method thereof - Google Patents

Abstract

The invention provides moisturizing and repairing essence milk and a preparation method thereof, wherein the moisturizing and repairing essence milk comprises the following components: chitosan, oligopeptide-1, sodium hyaluronate, vitamin B-5, squalane, mussel mucin, butanediol, glycerol, potassium sorbate, xanthan gum and deionized water. The invention aims to provide a moisturizing essence makeup product which has low irritation and sensitization, can stabilize the skin state, repair moisturizing superficial barriers, promote the regeneration of collagen on the skin, and reduce inflammation, thereby achieving the moisturizing effects of moisturizing, anti-sensitization and relieving red swelling and dryness.

Description

Moisturizing and repairing essence milk and preparation method thereof

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to moisturizing and repairing essence milk and a preparation method thereof.

Background

With the progress of basic material life, people pay more and more attention to higher pursuit and enjoyment. Under the condition that the conditions allow, people have more and more increased proportion of health care and maintenance in daily life, such as diet exercise and skin care and beauty. Skin has always been the first focus of anti-aging, which is not only the basis of facial appearance, but also an important barrier to the contact of the human body with the outside. The skin of the face, which is the most seriously damaged part which is subjected to sunlight ultraviolet oxidation and the like every day, can generate various stimulation injuries along with the change of environmental climate, air quality pollution and the like, and can easily cause a plurality of skin problems such as acne, color spots, acne, dry lines, wrinkles and the like along with free radicals and excrement formed by normal metabolic oxidation of a human body. Among various problems, moisture retention is the key to protect the skin barrier, and various skin problems are caused by the fact that the skin barrier is damaged, metabolic function is abnormal, and meanwhile, the multiplication of various floras is abnormally increased, so that inflammatory reaction is caused. The skin is the largest organ of the human body, and intact and good skin has a natural barrier function, and can protect various organs and tissues in the body from being damaged by mechanical, physical, chemical and biological harmful factors in the external environment, and on the other hand, can also prevent the loss of various nutrients, electrolytes and moisture in the tissues. The skin barrier is mainly composed of the stratum corneum, structural lipids and the skin lipid membrane, wherein the former two constitute a brick wall-like structure and are important constituents of the skin barrier, and the skin lipid membrane is the outermost defensive line of the skin barrier. Studies have shown that when the skin barrier is damaged, the density of bacteria implanted on the skin is several tens of times that of healthy skin, which greatly increases the probability of skin infection. The moisturizing product is mainly used for supplementing water-fat membranes and intercellular mortar of stratum corneum by nutrition, reinforcing the urban wall structure of a skin barrier, resisting external risks, simultaneously locking water to prevent loss, and further avoiding the problems of dry skin, dermatitis, sensitivity and the like.

Disclosure of Invention

The invention aims to provide a moisturizing and repairing essence.

Still another object of the present invention is to: provides a preparation method of the moisturizing and repairing essence milk.

The purpose of the invention is realized by the following scheme: a moisturizing and repairing essence milk comprises: chitosan, oligopeptide-1, sodium hyaluronate, vitamin B-5, squalane, mussel mucin, butanediol, glycerol, potassium sorbate, xanthan gum and deionized water, wherein the components in percentage by mass are as follows: 0.1-2% of chitosan, 1-5% of oligopeptide-1, 0.01-0.5% of sodium hyaluronate, 1-10% of vitamin B-5, 1-5% of squalane, 0.05-0.15% of mussel mucin, 0.1-1.5% of butanediol, 1-5% of glycerol, 0.1-1% of potassium sorbate, 0.01-1% of xanthan gum and the balance of deionized water.

Preferably, the moisturizing and repairing essence milk comprises the following components in percentage by mass: 0.3-1% of chitosan, 2.5-5% of oligopeptide-1, 0.15-0.35% of sodium hyaluronate, 3-5% of vitamin B-5, 2-4% of squalane, 0.1-0.15% of mussel mucin, 0.5-1% of butanediol, 2-5% of glycerol, 0.5-1% of potassium sorbate, 0.05-0.5% of xanthan gum and the balance of deionized water.

Further, the pH value of the essence milk component mixture is 5.8-7.4, and preferably is slightly acidic.

The raw materials used in the invention can be purchased from the market, and the efficacy of each effective additive component is respectively as follows:

squalane, a very common biomimetic component, is widely used in the preparation of skin care cosmetic products, has high affinity with human skin as a hydride of squalene, which is a main constituent of human sebum, is similar to and more soluble in the sebum component, and forms a protective film on the surface to play a barrier role. The sebum membrane can effectively lock water to prevent dehydration, simultaneously shield infiltration of part of external impurities, humidify and soften the skin, increase the health and flexibility of the skin, prevent dry cracking and fine lines and further inhibit the growth of specific microorganisms. Squalane can be easily dissolved in a skin lipid membrane, is easier to store than squalene, is fast to absorb and prevents dryness, inhibits oxidation and repairs a skin barrier, and promotes blood microcirculation and cell metabolism, and can be called a universal medicine.

Oligopeptide-1, a synthetic peptide consisting of glycine, histidine and lysine and comprising 3 disulfide bonds. The molecular weight of the oligopeptide-1 precursor is 6KD, the volume of the oligopeptide-1 precursor is 3000 times smaller than that of bacteria, the oligopeptide-1 precursor can be easily absorbed by skin, and can be used as a raw material of the skin to participate in the extension of peptide chains and improve the synthesis of proteins, particularly dermal collagen and elastin, thereby helping the skin to improve metabolism and improving the repair capacity of the skin. The skin care product can effectively promote the water circulation of the skin, keep the skin elastic and tensile, enhance the activity of muscle bottom cells, eliminate melanin pox and dark ink, and has no stimulation and burden to the skin, and the long-term use nursing effect is mild and comprehensive.

Mussel mucin is extracted from marine mussel byssus, has a large amount of positive charges and a very unique dopa group, so the mussel mucin can be effectively attached to the surface of human skin to be effectively combined with cells in a body fluid or water isolation way, and the intercellular creeping substitution is promoted. Because all cells of the human body are negatively charged, and the mussel mucin is positively charged, in the range covered by the mussel mucin, the cells with negative charge can quickly crawl towards the direction with positive charge, so that the repairing speed promoted by the mussel mucin is remarkably increased compared with the repairing speed of the skin, and the effect of quickly repairing the skin barrier is further realized. Mussel mucin has antiallergic and desensitizing effects. Since mussel mucin is a macromolecular protein that itself has a very high charge of positive charge, while skin cells and tissues are negatively charged. The mussel mucin forms a bracket and a net on the surface layer of the skin through the interaction of positive electricity and negative electricity and dopa groups of the mussel mucin, and is firmly attached to the surface of the skin. The mussel mucin occupies a number of sites on the skin surface. Avoiding the exogenous allergens from binding to these sites on the skin surface of the human body. Has antiallergic effect. And then the skin cells are prevented from being oxidized by the self-inhibition effect of the generation of free radicals, the health state of the cells is improved, the thickness of a skin protection layer is gradually thickened, and the desensitization result is realized.

Chitosan, a high-molecular active ingredient extracted from marine organisms, has excellent characteristics of safety, no toxicity, antibiosis, moisture retention, oxidation resistance, degradability and the like, and is widely used. The glucosamine which is the component of the composition unit is similar to the important component ceramide of the human epidermal lipid membrane layer, and has good compatibility and film forming property; it can inhibit tyrosinase activity and melanin formation, has good water absorption and moisture retention due to amino groups bound with water molecules, and is beneficial to skin health.

Vitamin B-5, a group B antibiotic, acts on the skin to promote keratinization of the skin. In addition, the vitamin B-5 has the function of promoting the hydration of the horny layer of the skin, so that the moisture preservation and the water supplement of the horny layer can be realized. Vitamin B-5 also has anti-inflammatory effect, such as resisting erythema caused by ultraviolet rays and relieving itching, and has obvious effect on calming the skin. In addition, vitamin B-5 is also a nutritional supplement, and vitamin B-5 can also supplement the nutritional imbalance of skin when applied to the skin.

Xanthan gum is a biopolymer obtained by a series of microbial fermentation processes of starch as a raw material, and the main components of the biopolymer are glucose, mannose, glucuronic acid and the like, and the biopolymer has outstanding high viscosity and water solubility, excellent temperature and ph stability and compatible buffer performance. It is a polyol having a multi-side chain linear structure. The hydroxyl group of the emulsifier can be combined with water molecules to form a stable net structure, and the emulsifier has high viscosity at very low concentration, has obvious thickening effect and has super performance as an emulsifying thickener.

The butanediol is a micromolecular humectant with excellent performance, has the effects of a solvent and a preservative in a cosmetic product, has the functions of water locking and antibiosis, and can improve the water resistance of the product. The skin-care product has the characteristics of no influence of hydrolysis, temperature and ph value, can effectively improve the skin feel of the product, and has the problems of mildness, no stimulation and the like.

The potassium sorbate is a good component of an antiallergic agent and a freckle removing agent, has the effects of inhibiting bacteria, diminishing inflammation and resisting allergy, can promote the absorption of skin on nutrient substances, particularly minerals and trace elements, can promote the metabolism of the skin, and removes certain metabolic wastes, such as oxygen radicals and the like.

Glycerin, a commonly used small molecule moisture absorption component, has strong hygroscopicity, can isolate air, prevent moisture evaporation, absorb a certain amount of moisture from dermis or external environment, supplement cuticle moisture loss, lock water and preserve moisture, is widely developed and applied to the preparation of skin care products, is safe and mild, and does not need worry.

The product form related by the invention can be a moisturizing facial mask, a moisturizing emulsion, a moisturizing cream or a moisturizing essence.

The product of the invention simultaneously considers the aspects of oxidation resistance, bacteriostasis, inflammation diminishing and calming, simultaneously reduces the stimulation sensitivity, effectively and perfectly solves most of the skin problems encountered after the skin is too much illuminated and is damaged by oxidation, simultaneously maintains low negative effect and stable skin state, adopts the materials matched according to the properties of the materials, not only avoids the problems that certain components are easy to denaturalize when meeting the light sensitivity in the daytime but also causes stimulation and invalidation to the skin, but also properly selects an emulsifying solvent system with higher corresponding permeability according to the structure of the skin of a human body so as to improve the permeability and the absorption efficiency.

The natural non-burden moisturizing and repairing essence emulsion has the formula, and has the effects of regulating water and oil balance, resisting oxidation, stabilizing a cutin structure, locking water and simultaneously having low sensitization irritation in the process of supplementing nutrients required by skin. When the water content of the skin rises, the internal structure is stable, and after the barrier function is ensured, the skin can have a healthy and complete skin state. After the water content rises, the internal cutin is arranged tightly, and the skin looks fuller and more transparent, white and elastic.

The invention also provides a preparation method, which comprises the following steps:

(1) Mixing sodium hyaluronate, glycerol, deionized water, potassium sorbate and xanthan gum into a stirring container, fully mixing and uniformly stirring, slightly heating, and keeping stirring for 3-5 minutes while heating;

(2) After the temperature of the mixture container is reduced to 35-40 ℃, adding vitamin B-5, butanediol, chitosan, squalane, oligopeptide-1 and mussel mucin, and uniformly stirring to obtain a mixed product;

(3) Adding appropriate amount of citric acid, triethanolamine, ionized water, etc. to desired volume and adjust pH value, sterilizing under high pressure by ultraviolet irradiation after blending, vacuum emulsifying and homogenizing, and sealing the obtained essence milk in a container.

According to the preparation process method provided by the invention, the preparation of the mixed product at each stage and the addition sequence of the raw material components have a decisive promotion effect on the stability and efficacy of the resulting product, and the moisturizing essence emulsion product which is uniformly mixed and is convenient to store is obtained by adding and mixing step by step, finally adjusting the pH, carrying out ultraviolet high-pressure sterilization and emulsifying and homogenizing.

Preferably, in the step (1), the sodium hyaluronate, the glycerol, the deionized water, the potassium sorbate and the xanthan gum are mixed in a stirring container, fully mixed and stirred, heated to 80 ℃, and cooled to about 35 ℃ after being completely dissolved after waiting for about 30 minutes to obtain a mixed solution.

Preferably, in the step (2), after the mixed solution in the previous step is cooled to about 35 ℃, vitamin B-5, butanediol, chitosan, squalane, oligopeptide-1 and mussel mucin are added and stirred uniformly to obtain a mixed product.

The invention has the beneficial effects that: the moisturizing essence emulsion prepared by the method has light and smooth texture, is not stuffy and oily, adopts the active special components which are mostly natural active extract components, and is matched with auxiliary components such as glycerin, vitamin B-5 and the like with strictly controlled dosage so as to achieve the effects of no stimulation, good absorption, regulation of skin metabolic balance, moisturizing and water locking, resistance to external damage to a certain extent, stabilization of skin state, inflammation resistance and allergy resistance after long-term use.

Detailed Description

In order to facilitate further elucidation and understanding of the invention, embodiments of the invention will now be described in more detail with reference to the examples. The following examples are merely illustrative of the present invention and the scope of the invention described should not be limited to the examples.

The following examples are illustrative of the preferred embodiments of the present invention, but other changes, modifications, substitutions and simplifications which do not depart from the spirit and principles of the present invention should be construed as equivalents thereof.

The moisturizing essence milk comprises the following components in percentage by mass: 0.5 percent of chitosan, 2.5 percent of oligopeptide-1, 0.35 percent of sodium hyaluronate, 3.5 percent of vitamin B-5, 3 percent of squalane, 0.1 percent of mussel mucin, 1 percent of butanediol, 3.5 percent of glycerin, 0.5 percent of potassium sorbate, 0.35 percent of xanthan gum and the balance of deionized water, and the preparation method comprises the following steps:

(1) Putting sodium hyaluronate, glycerol, deionized water, potassium sorbate and xanthan gum into a stirring container, fully mixing and uniformly stirring, heating to 80 ℃, standing for about 30 minutes after the sodium hyaluronate, glycerol, deionized water, potassium sorbate and xanthan gum are completely dissolved, and cooling to about 40 ℃;

(2) Adding vitamin B-5, butanediol, chitosan, squalane, oligopeptide-1 and mussel mucin into the mixture obtained in the step (1), and uniformly stirring to obtain a mixed product;

(3) Adding pH regulator such as citric acid to the mixed product to stabilize pH at about 5.8, sterilizing under ultraviolet high pressure, emulsifying and homogenizing to obtain moisture-keeping essence milk, and storing in vacuum package.

According to the 'evaluation criteria of the declaration of efficacy of cosmetics' implemented by the national drug administration in 2021, 5 months, the patch experiment on human skin sealing is selected as a safety test item in the embodiment, 20 volunteers are selected, the moisturizing essence emulsion of the embodiment is applied to 10 of the experiencers, purified distilled water is applied to the other 10 of the experiencers, and the patch experiment is synchronously performed. The results were: no allergic stress reaction such as skin red swelling, hot pain and spots is found in the group 2, so that the use safety of the product is ensured to a certain extent, and no adverse skin reaction is caused in expectation.

Next, the product was tested for moisturizing efficacy: for 20 volunteers in the patch experiment, according to QB/T4256-2011 evaluation guidelines of cosmetic moisturizing efficacy, a certain amount of A moisturizing essence milk is respectively tried from every 10 groups of groups, B deionized water is used for being smeared on a 3 x 2cm area of cheek of a subject, and the content of water and oil in the stratum corneum of skin at 1h and 3h and the loss rate of water and oil in the stratum corneum of the skin at the time before the product is used (initial value), 0h after the product is used (test after beating 10s after smearing and wiping the sample) are respectively measured by an instrument MOISTURETERSC MSC1212 (DELFIN) and an instrument TAPOMETER SWL5167 (DELFIN), and the details are shown in the following table.

From the above table, in the experimental group using the moisturizing essence milk, the water content data is obviously improved in a short period after use compared with the control group, the water content of 2 groups is improved from the time before use to 0h, and the water content is gradually reduced along with the gradual lapse of time; the oil content is opposite to the oil content, the initial oil content is larger than the water content value, which indicates that most of the skin of the subject is unbalanced in water and oil, the water is low and the oil is high, which is the embodiment of the water shortage of the mixed type skin, by adding different products (A moisturizing essence milk and B deionized water), the water content is in an upward trend at the initial stage, the oil content is in a downward trend correspondingly, and along with the time length, the water content falls back to be close to the initial value, and the oil content is increased back to be close to the initial value.

In the last 3h interval, the water content and the oil content of the control group return to the levels which are closer to the initial values (before any product is used), the skin water content of the test subject in the experimental group still shows that the skin water content of the test subject is higher than that of the control group test subject, and the corresponding oil content is slightly lower than that of the control group test subject, which is enough to show that the moisturizing cream has the basic effects of water locking and moisturizing and water-oil balance adjustment.

Then, the experience person continues to use 2 products (namely, A moisturizing essence milk and B deionized water) respectively corresponding to the groups in the next 28 days, namely, one skin metabolism period according to the previous experiment and control grouping, the skin brightness of the test person is slightly improved, the conditions of color spots, darkness and the like are obviously slightly improved, and simultaneously the fragility and the sensitivity of uniform skin color, red blood filaments and the like are relieved to a certain extent. According to the reflection of a tester, the skin care product is generally considered to be mild, non-irritant, non-inflammatory, non-stuffy and non-sensitive to skin after being used.

From the tests and the results, the product of the embodiment can not cause adverse reactions to the skin of the subject, and shows that the ingredient combination formula of the moisturizing essence milk has low irritation and personal safety, and has the effects of moisturizing the skin, maintaining the skin stable, moisturizing and locking the water. Meanwhile, through the use comparison test of 28 days, namely a skin metabolism period, the improvement of the aspects of removing pigmentation, repairing barriers, metabolizing muscle bottom cells and the like of the skin of the subject can be seen from the improvement of the skin condition.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Those who do not specify specific conditions in the examples of the present invention follow conventional conditions or conditions recommended by the manufacturer. The raw materials or instruments of the reagents are not indicated by manufacturers, and all the reagents are conventional products which can be obtained by market purchase.

Claims (5)

1. The moisturizing and repairing essence milk is characterized by comprising the following components: comprises the following components: the skin care composition comprises chitosan, oligopeptide-1, sodium hyaluronate, vitamin B-5, squalane, mussel mucin, butanediol, glycerol, potassium sorbate, xanthan gum and deionized water, and comprises the following components in percentage by mass: 0.1-2% of chitosan, 1-5% of oligopeptide-1, 0.01-0.5% of sodium hyaluronate, 1-10% of vitamin B-5, 1-5% of squalane, 0.05-0.15% of mussel mucin, 0.1-1.5% of butanediol, 1-5% of glycerol, 0.1-1% of potassium sorbate, 0.01-1% of xanthan gum and the balance of deionized water.

2. The moisturizing and repairing essence milk according to claim 1, characterized in that: the weight percentages of the components are as follows: 0.3-1% of chitosan, 2.5-5% of oligopeptide-1, 0.15-0.35% of sodium hyaluronate, 3-5% of vitamin B-5, 2-4% of squalane, 0.1-0.15% of mussel mucin, 0.5-1% of butanediol, 2-5% of glycerol, 0.5-1% of potassium sorbate, 0.05-0.5% of xanthan gum and the balance of deionized water.

3. The moisturizing and repairing essence milk according to claim 1 or 2, wherein: making into facial mask, lotion, cream or essence.

4. The preparation method of the moisturizing and repairing essence milk according to any one of claims 1 to 3, which is characterized by comprising the following steps:

(1) Putting 0.01-0.5% of sodium hyaluronate, 1-5% of glycerin, 0.1-1% of potassium sorbate, 0.01-1% of xanthan gum and deionized water into a stirring container, fully mixing and stirring uniformly, heating to 80 ℃ and continuously stirring for 3-5 minutes, and standing and cooling the obtained mixed solution;

(2) After the temperature of the mixture is reduced to 35-40 ℃, 0.1-2% of chitosan, 1-5% of oligopeptide-1, 1-5% of squalane, 0.05-0.15% of mussel mucin, 1-10% of vitamin B-5 and 0.1-1.5% of butanediol are added and stirred uniformly to obtain a mixed product;

(3) Adding proper citric acid, triethanolamine and ionized water to fix the volume and adjust the pH value to 5.8-7.4, after blending, performing ultraviolet irradiation autoclaving and vacuum emulsification homogenization to obtain the moisturizing repair essence milk, and sealing and storing in a container.

5. The preparation method of the moisturizing and repairing essence milk according to claim 4, characterized by comprising the following components in percentage by mass: 0.5 percent of chitosan, 2.5 percent of oligopeptide-1, 0.35 percent of sodium hyaluronate, 3.5 percent of vitamin B-5, 3 percent of squalane, 0.1 percent of mussel mucin, 1 percent of butanediol, 3.5 percent of glycerol, 0.5 percent of potassium sorbate, 0.35 percent of xanthan gum and the balance of deionized water, and the preparation method comprises the following steps:

(1) Putting sodium hyaluronate, glycerol, deionized water, potassium sorbate and xanthan gum into a stirring container, fully mixing and uniformly stirring, heating to 80 ℃, standing the mixture until the mixture is cooled to 35-40 ℃ after the mixture is completely dissolved;

(2) Adding vitamin B-5, butanediol, chitosan, squalane, oligopeptide-1 and mussel mucin into the mixture obtained in the step (1), and uniformly stirring to obtain a mixed product;

(3) Adding citric acid as a pH regulator into the mixed product until the pH value is stabilized at 5.8, emulsifying and homogenizing after ultraviolet high-pressure sterilization to obtain the moisturizing and repairing essence milk, and storing in a vacuum package.