CN114432179A - Formula and preparation method of chitosan water replenishing repair essence cosmetic - Google Patents
Formula and preparation method of chitosan water replenishing repair essence cosmetic Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention belongs to the technical field of cosmetics, solves the problem of poor compatibility of chitosan, realizes wide application of chitosan in the field of cosmetics, and particularly relates to a formula of a moisturizing and repairing essence containing chitosan and a preparation method of the moisturizing and repairing essence. The essence mainly comprises the following components: purified water, glycerol, chitosan, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, xanthan gum, allantoin, azone, caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerol. The chitosan moisturizing and repairing essence does not contain essence, alcohol, pigment and preservative, is safe and efficient, does not have any irritation to skin, and is suitable for all skin types. The skin care product is fresh and non-greasy, has the effects of efficiently moisturizing, remolding skin barriers, deeply repairing damaged epidermal cells, adsorbing heavy metal residues on the skin, nourishing and moisturizing the skin, preventing skin aging and brightening the skin color, and can make the skin feel silky and smooth after long-term use.
Description
Technical Field
The invention belongs to the technical field of cosmetics, provides a preparation method of a cosmetic containing a carboxymethyl chitosan component, and particularly relates to a preparation method of a cosmetic added with the carboxymethyl chitosan component.
Background
The human skin contains a large amount of water, the water content of the horny layer of the skin is about 15-30% under an ideal condition, the water plays a vital role in regulating the physiological function of a human body and the skin of the human body, and the skin contains enough water, so that the skin aging can be delayed, and certain skin diseases can be prevented. Meanwhile, the skin of the user looks flexible, soft and elastic, which is also a common pursuit of every beauty lover. Although the water content and water-holding function in the skin are a part of the innate factors, the acquired factors have a similarly great influence on the water content and water-holding function in the skin. Age, seasonal changes, ultraviolet rays, air-conditioning environment, computer radiation, self health conditions and other adverse factors can cause imbalance of water and oil in the skin of a human body and dryness of the skin. When the water content in the stratum corneum of the skin is less than 15%, the skin feels uncomfortable due to lack of water, and the symptoms are mainly manifested by tight and dark yellow skin, dry peeling of individual parts, and severe skin itching or inflammation.
Therefore, moisture retention research is the hot spot of cosmetic and dermatology research at present, and generally, a moisture retention agent is added into cosmetics for maintaining or increasing the water content of the stratum corneum of the skin, so as to improve and solve the common skin problems. Chitosan is a deacetylated product of natural chitin, is the only animal cellulose with positive charges in the nature, is known as the sixth element of life, has no endothelial irritation and cytotoxicity, has good biological safety, biodegradability, biocompatibility and heavy metal adsorbability, and is widely applied to the fields of food, medical treatment, cosmetics, artificial tissues, drug sustained release carriers, gene transfer carriers, drug development and the like. However, chitosan has limited use in the cosmetic field due to its poor compatibility.
The research of the invention finds that carboxymethyl chitosan is one of the high-grade derivatives of chitosan, and has good water solubility, film forming property, water replenishing and moisture preserving property, antibacterial property, wound healing property and strong heavy metal chelating effect. The carboxymethyl chitosan is prepared by reacting chitosan with chloroacetic acid under alkaline condition. According to the different substitution positions of carboxymethyl on chitosan, carboxymethyl chitosan can be divided into N-carboxymethyl chitosan, O-carboxymethyl chitosan and N, O-carboxymethyl chitosan, and the product is N, O-carboxymethyl chitosan. Carboxymethyl chitosan is an amphoteric polyelectrolyte, solves the flocculation of chitosan, increases the compatibility and stability of the product, has strong stability, is suitable for a wide pH range, and is very stable when being continuously heated at high temperature. The carboxymethyl chitosan has the moisture retention equivalent to hyaluronic acid and can be used as a humectant of cosmetics; the antibacterial and wound healing functions can efficiently repair damaged epidermal cells; the strong heavy metal chelating effect can adsorb heavy metal residues caused by color cosmetics or inferior cosmetics to skin.
The invention provides a safe and reliable water replenishing repair essence cosmetic for vast women who love beauty, which is purely natural, non-toxic, non-irritant, water replenishing and moisturizing, repairs damaged skin epidermal cells, adsorbs heavy metal residues on skin, has a wide PH adaptation range and excellent thermal stability, adapts to market demands, and has good market popularization prospect.
Disclosure of Invention
The invention aims to solve the problem of wide application of chitosan in cosmetics, and provides chitosan moisturizing repair essence with good moisturizing and repairing performances and a preparation method thereof.
Based on the purpose, the invention adopts the following technical scheme: the chitosan moisturizing and repairing essence consists of purified water, glycerol, chitosan, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, xanthan gum, allantoin, azone, caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin.
Further, the chitosan moisturizing and repairing essence comprises the following components in percentage by mass, based on 100% of the total mass of the components: 5-10% of glycerol, 0.1-1% of chitosan, 0.5-2% of betaine, 0.1-0.5% of ultra-low molecular sodium hyaluronate, 0.1-0.5% of medium molecular sodium hyaluronate, 0.1-0.4% of xanthan gum, 0.1-0.5% of allantoin, 0.5-2% of azone, 0.1-0.3% of caprylyl hydroximic acid, 0.35-0.6% of 1, 2-hexanediol, 0.05-0.1% of ethylhexyl glycerol and the balance of purified water to 100%.
Further, the chitosan moisturizing and repairing essence comprises the following components in percentage by mass, based on 100% of the total mass of the components: 5% of glycerol, 0.5% of chitosan, 1% of betaine, 0.15% of ultra-low molecular sodium hyaluronate, 0.15% of medium molecular sodium hyaluronate, 0.2% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethyl hexyl glycerol and the balance of purified water to 100%.
Further, the chitosan component contained in the raw material component of the chitosan moisturizing and repairing essence is carboxymethyl chitosan, and the chitosan is prepared by reacting chitosan with chloroacetic acid under an alkaline condition. According to the substitution position of carboxymethyl on chitosan, carboxymethyl chitosan can be classified into N-carboxymethyl chitosan, O-carboxymethyl chitosan and N, O-carboxymethyl chitosan.
Further, the carboxymethyl chitosan is N, O-carboxymethyl chitosan.
Further, the total adding proportion of three components, namely caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexyl glycerin in the raw material components in the chitosan moisturizing and repairing essence is 0.5-1%.
Further, the total adding proportion of three components, namely caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexyl glycerin in the raw materials of the chitosan moisturizing and repairing essence is 0.8%.
Further, the molecular weight of the ultra-low molecular sodium hyaluronate in the raw material components of the chitosan water replenishing and repairing essence is less than or equal to 5000 Da; the molecular weight of the medium molecular sodium hyaluronate is 800000-1300000 Da.
A preparation method of chitosan moisturizing and repairing essence comprises the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500-600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
Further, when the temperature reaches 75 ℃, the stirring time is controlled to be 20min, and the rotating speed of the stirrer is controlled to be 500-600 revolutions per minute.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a formula and a preparation method of chitosan-containing moisturizing and repairing essence, and realizes wide application of chitosan in the field of cosmetics.
The chitosan moisturizing and repairing essence provided by the invention is pure natural, non-toxic, non-irritant, refreshing and non-greasy, has a wide pH adaptation range and excellent thermal stability, adapts to market demands, and has a good market popularization prospect.
The chitosan, the sodium hyaluronate and the xanthan gum in the components of the chitosan moisturizing and repairing essence disclosed by the invention have a thickening effect, do not contain any chemical synthesis thickening agent, essence, alcohol, pigment, preservative and the like, do not have any irritation to skin, and have the advantages of safety and high efficiency.
The chitosan moisturizing repair essence disclosed by the invention has the effects of efficiently moisturizing, deeply repairing damaged epidermal cells, adsorbing heavy metal residues on skin, nourishing and moisturizing the skin, preventing skin aging and brightening skin color, and can make the skin silky and smooth in sense of double feeling after being used for a long time.
Detailed Description
Example 1
1. Chitosan water replenishing and repairing essence and preparation method thereof
The chitosan water replenishing and repairing essence takes deionized purified water as a basic solvent, the total mass is 100%, and the addition amount of the components in percentage by mass is as follows: 5% of glycerol, 0.5% of chitosan, 1% of betaine, 0.15% of ultra-low molecular sodium hyaluronate, 0.15% of medium molecular sodium hyaluronate, 0.2% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethylhexyl glycerol and the balance of purified water to 100%.
Wherein the molecular weight of the ultra-low molecular sodium hyaluronate is 5000 Da; the molecular weight of the medium molecular sodium hyaluronate is 800000-1300000 Da.
The preparation method of the chitosan water replenishing and repairing essence comprises the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500 plus 600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
The prepared essence has moderate viscosity and stable property, and the viscosity of the essence is not obviously changed compared with the normal-temperature stored essence after being refrigerated at the low temperature of 2-5 ℃ for 48h and stored at the constant temperature of 40 ℃ for 48 h. The prepared essence is qualified according to the light industry standard QB/T2660-2004 through a microorganism detection experiment.
The chitosan has obvious functions of moisturizing, activating and repairing damaged body cells, preventing skin roughness and aging, inhibiting harmful bacteria on the surface of the skin from breeding, inhibiting bacteria and resisting skin diseases, adsorbing residual heavy metal on the skin and the like; the ultra-low molecular sodium hyaluronate is absorbed through the skin to directly reach the dermis, deeply moisturizes, resists aging and repairs after being dried in the sun; the sodium hyaluronate with the medium molecules has smooth skin feel, no stickiness, high elasticity, long-acting moisture retention and hyaluronidase degradation resistance, and can form a reticular water film on the surface of the skin, lock water, retain moisture, isolate pollution and protect the skin; the allantoin has the effects of shading, sterilizing, preventing corrosion, resisting inflammation and resisting oxidation, so that the skin can keep moisture, is moist and soft, and the moisturizing performance of the allantoin is further enhanced.
2. Effect test of chitosan water replenishing repair essence
The test subjects were: 20 patients with dry skin (10 men and women, respectively) aged 25 to 55 years, the test period is in the autumn and winter season where the skin is most easily dried and peeled, because the humidity in the air is low and the moisturizing environment is poor, so that the moisturizing effect of the invention can be better illustrated.
The test method comprises the following steps: the samples of the skin care and moisturizing lotion are selected for each user to be directly used after cleaning the face twice in the morning and in the evening, and the using amount of each time is moderate. And tracking and observing each user and recording the use condition in detail.
Test results show that after the moisturizing lotion is used for one week, compared with the prior phenomenon that the skin is dry and peeled, each user has obvious relief and does not have adverse reactions such as allergy and the like; after the skin care product is used for two weeks, the skin of each user becomes moist compared with the prior skin, the phenomenon of dry skin and desquamation basically does not exist, and adverse reactions such as allergy and the like do not exist; after the skin care product is used for three weeks, the skin of each user becomes abnormal and moist compared with the prior skin, the phenomenon of skin dryness and desquamation does not exist, and adverse reactions such as allergy and the like do not exist. Therefore, the skin-care moisturizing lotion is suitable for long-term use, can restore the elasticity of the skin and prevent premature senility while maintaining the skin moisturizing property, and has the beautifying effect.
Example 2
The chitosan moisturizing and repairing essence disclosed by the invention is different from the embodiment 1 only in the component difference, the chitosan moisturizing and repairing essence disclosed by the embodiment of the invention takes deionized purified water as a basic solvent, the total mass is 100%, and the addition amount of the components in percentage by mass is as follows: 8% of glycerol, 0.6% of chitosan, 1.5% of betaine, 0.2% of ultra-low molecular sodium hyaluronate, 0.2% of medium molecular sodium hyaluronate, 0.2% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethylhexyl glycerol and the balance of purified water to 100%.
The preparation method of the chitosan water replenishing and repairing essence comprises the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500 plus 600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
The chitosan moisturizing and repairing essence provided by the embodiment has moderate viscosity, and the moisturizing and moisturizing effect of the chitosan moisturizing and repairing essence is the same as that of the chitosan moisturizing and repairing essence in the embodiment 1.
Example 3
The chitosan moisturizing and repairing essence disclosed by the invention is different from the embodiment 1 only in the component difference, the chitosan moisturizing and repairing essence disclosed by the embodiment of the invention takes deionized purified water as a basic solvent, the total mass is 100%, and the addition amount of the components in percentage by mass is as follows: 5% of glycerol, 0.8% of chitosan, 2% of betaine, 0.3% of ultra-low molecular sodium hyaluronate, 0.3% of medium molecular sodium hyaluronate, 0.15% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethylhexyl glycerol and the balance of purified water to 100%.
The preparation method of the chitosan water replenishing and repairing essence comprises the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500 plus 600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
The chitosan moisturizing and repairing essence provided by the embodiment has moderate viscosity, and the moisturizing and moisturizing effect of the chitosan moisturizing and repairing essence is the same as that of the chitosan moisturizing and repairing essence in the embodiment 1.
Example 4
The chitosan moisturizing and repairing essence disclosed by the invention is different from the embodiment 1 only in the component difference, the chitosan moisturizing and repairing essence disclosed by the embodiment of the invention takes deionized purified water as a basic solvent, the total mass is 100%, and the addition amount of the components in percentage by mass is as follows: 4% of glycerol, 0.4% of chitosan, 1% of betaine, 0.1% of ultra-low molecular sodium hyaluronate, 0.1% of medium molecular sodium hyaluronate, 0.2% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethyl hexyl glycerol and the balance of purified water to 100%.
The preparation method of the chitosan water replenishing and repairing essence comprises the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500 plus 600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
The chitosan moisturizing and repairing essence provided by the embodiment has moderate viscosity, and the moisturizing and moisturizing effect of the chitosan moisturizing and repairing essence is the same as that of the chitosan moisturizing and repairing essence in the embodiment 1.
Example 5
The chitosan moisturizing and repairing essence disclosed by the invention is different from the embodiment 1 only in the component difference, the chitosan moisturizing and repairing essence disclosed by the embodiment of the invention takes deionized purified water as a basic solvent, the total mass is 100%, and the addition amount of the components in percentage by mass is as follows: 5% of glycerol, 0.5% of chitosan, 1% of betaine, 0.2% of ultra-low molecular sodium hyaluronate, 0.2% of medium molecular sodium hyaluronate, 0.4% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethyl hexyl glycerol and the balance of purified water to 100%.
The preparation method of the chitosan water replenishing and repairing essence comprises the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500 plus 600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
The chitosan moisturizing repair essence provided by the embodiment has the same moisturizing effect as the chitosan moisturizing repair essence in the embodiment 1, but the viscosity is increased, so that the chitosan moisturizing repair essence is not suitable for filling.
Example 6
The chitosan moisturizing and repairing essence disclosed by the invention is different from the embodiment 1 only in the component difference, the chitosan moisturizing and repairing essence disclosed by the embodiment of the invention takes deionized purified water as a basic solvent, the total mass is 100%, and the addition amount of the components in percentage by mass is as follows: 5% of glycerol, 0.5% of chitosan, 1% of betaine, 0.1% of ultra-low molecular sodium hyaluronate, 0.1% of medium molecular sodium hyaluronate, 0.1% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethyl hexyl glycerol and the balance of purified water to 100%.
The preparation method of the chitosan water replenishing and repairing essence comprises the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500 plus 600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
The chitosan moisturizing repair essence provided by the embodiment has the same moisturizing effect as the chitosan moisturizing repair essence in the embodiment 1, but the viscosity is reduced, so that the chitosan moisturizing repair essence is not suitable for filling.
Claims (10)
1. The chitosan moisturizing and repairing essence is characterized by consisting of purified water, glycerol, chitosan, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, xanthan gum, allantoin, azone, caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin.
2. The chitosan water replenishing and repairing essence of claim 1, wherein the total mass of raw material components in the essence is 100%, and the components comprise the following components in percentage by mass: 5-0% of glycerol, 0.1-1% of chitosan, 0.5-2% of betaine, 0.1-0.5% of ultra-low molecular sodium hyaluronate, 0.1-0.5% of medium molecular sodium hyaluronate, 0.1-0.4% of xanthan gum, 0.1-0.5% of allantoin, 0.5-2% of azone, 0.1-0.3% of caprylyl hydroximic acid, 0.35-0.6% of 1, 2-hexanediol, 0.05-0.1% of ethylhexyl glycerol and the balance of purified water to 100%.
3. The chitosan water replenishing and repairing essence of claim 2, wherein the total mass of the raw material components in the essence is 100%, and the addition amount of the components in percentage by mass is as follows: 5% of glycerol, 0.5% of chitosan, 1% of betaine, 0.15% of ultra-low molecular sodium hyaluronate, 0.15% of medium molecular sodium hyaluronate, 0.2% of xanthan gum, 0.2% of allantoin, 0.5% of azone, 0.2% of caprylyl hydroximic acid, 0.55% of 1, 2-hexanediol, 0.05% of ethyl hexyl glycerol and the balance of purified water to 100%.
4. The chitosan moisturizing and repairing essence of any one of claims 1-3, wherein the chitosan is N-carboxymethyl chitosan or O-carboxymethyl chitosan or N, O-carboxymethyl chitosan.
5. The chitosan moisturizing repair serum of claim 4, wherein the chitosan is N, O-carboxymethyl chitosan.
6. The chitosan moisturizing and repairing essence as claimed in claim 2 or 5, wherein the total addition ratio of the three components of the caprylyl hydroximic acid, the 1, 2-hexanediol and the ethylhexyl glycerin in the raw materials of the essence is 0.5-1%.
7. The chitosan essence for replenishing water and repairing according to claim 6, wherein the total adding proportion of three components of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexyl glycerin in the raw materials of the essence is 0.8%.
8. The chitosan moisturizing repair essence of any one of claims 1,2, 3 and 7, wherein the molecular weight of the ultra-low molecular sodium hyaluronate is less than or equal to 5000 Da; the molecular weight of the medium molecular sodium hyaluronate is 800000-1300000 Da.
9. The preparation method of the chitosan moisturizing and repairing essence is characterized by comprising the following steps:
adding glycerol into deionized purified water, uniformly stirring, simultaneously starting to heat, setting the temperature to be 75-80 ℃, setting the rotating speed of a stirrer to be 500-600 revolutions per minute, sequentially adding allantoin, azone, betaine, ultra-low molecular sodium hyaluronate, medium molecular sodium hyaluronate, chitosan and xanthan gum into the system under the state of continuous stirring, starting timing when the temperature reaches 75 ℃, stirring for 20-30min at 75 ℃, then cooling to 25-45 ℃, adding a mixed solution of caprylyl hydroximic acid, 1, 2-hexanediol and ethylhexylglycerin into the system, and fully and uniformly stirring to obtain the chitosan water replenishing repair essence.
10. The preparation method of the chitosan moisturizing and repairing essence as claimed in claim 9, wherein when the temperature reaches 75 ℃, the stirring time is controlled to be 20min, and the rotation speed of a stirrer is controlled to be 500-600 rpm.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115400034A (en) * | 2022-07-22 | 2022-11-29 | 上海纳米技术及应用国家工程研究中心有限公司 | Moisturizing and repairing essence milk and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115400034A (en) * | 2022-07-22 | 2022-11-29 | 上海纳米技术及应用国家工程研究中心有限公司 | Moisturizing and repairing essence milk and preparation method thereof |
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