CN114796024A - Bionic sebum composition for skin barrier repair and preparation method and application thereof - Google Patents
Bionic sebum composition for skin barrier repair and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the technical field of cosmetics, and discloses a bionic sebum composition for skin barrier repair, and a preparation method and application thereof. The bionic sebum composition comprises the following components: grass cotton seed oil, glass chicory seed oil, evening primrose oil, tea seed oil and pepper fruit oil. The glass chicory seed oil and the evening primrose oil are rich in linoleic acid and gamma-linolenic acid and have good eliminating capacity on superoxide radical; the pepper fruit oil is rich in volatile oil, piperine, crude fat and various amide compounds, and can promote the osmotic absorption of nutrient substances; the grass cotton seed oil and the tea seed oil can play a role in astringing after the skin absorbs nutrient components, and inhibit harmful microorganisms from interfering the skin. The five components are used together, so that the skin absorption can be promoted, the skin barrier can be repaired, the oxidation resistance of the skin can be improved, and the loss of water and lipid substances can be reduced.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a bionic sebum composition for skin barrier repair, and a preparation method and application thereof.
Background
The skin barrier structure is a brick wall structure and is composed of a sebum membrane, horny layer keratin, lipid, dermal mucopolysaccharide, mucopolysaccharide and the like. The skin can not only prevent the invasion of harmful factors such as physical, chemical, biological and the like from the outside; and can avoid the loss of water, lipid and other substances in the epidermis and the dermis of the human body in daily life, and play the role of the skin barrier function through the skin. Skin sensitivity such as dry skin, skin aging, pigmentation, solar dermatitis, etc., all belong to impaired skin barrier. After the skin barrier is damaged, the loss of substances such as water, lipid and the like can be further accelerated, the skin barrier is more easily damaged by external stimulation and environmental change, and red swelling, local redness or other pathological changes and the like can be caused in severe cases.
At present, a variety of skin barrier function repairing cosmetics are available, and inflammation of damaged skin is reduced by enhancing the moisture retention of the surface layer of the skin or adding soothing components. For example, trehalose, hyaluronic acid, chitosan and other components are added to supplement water and moisturize, so that the effect of repairing the damaged skin barrier is achieved. This approach does not fundamentally address the problem of impaired skin barrier function. The normal function of the skin can be recovered through the effects of various plant essential oils, but many essential oils are easily absorbed by the skin, but the essential oils cannot play a role in repairing barriers and reducing the loss of water and lipid substances, and have the risk of causing skin allergy.
Therefore, there is a need to provide a biomimetic sebum composition for skin barrier repair that can promote absorption, repair skin barrier, improve skin oxidation resistance, and reduce water and lipid loss.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the bionic sebum composition for skin barrier repair provided by the invention can promote absorption, repair skin barriers, improve the oxidation resistance of skin and reduce the loss of water and lipid substances.
In a first aspect the present invention provides a biomimetic sebum composition for skin barrier repair.
Specifically, the bionic sebum composition for skin barrier repair comprises the following components: semen gossypii (Gossypium HERBACEUM) seed oil, herba Cichorii (Borago OFFICINALIS) seed oil, radix Oenotherae Erythrosepalae (Oenothera BIENNIS) oil, tea (CAMELLIA SINENSIS) seed oil, and fructus Piperis (Piper NIGRUM) fruit oil.
Preferably, the bionic sebum composition comprises the following components in parts by weight:
1-15 parts of grass cotton seed oil
5-20 parts of glass chicory seed oil
5-20 parts of evening primrose oil
1-20 parts of tea seed oil
0.5-10 parts of pepper fruit oil.
The invention can further promote absorption, repair skin barrier, improve skin oxidation resistance and reduce water and lipid loss by controlling the proportion of the components of the composition.
The bionic sebum composition comprises 1 part of grass cotton seed oil, 3 parts of grass cotton seed oil, 5 parts of grass cotton seed oil, 8 parts of grass cotton seed oil, 10 parts of grass cotton seed oil, 12 parts of grass cotton seed oil or 15 parts of grass cotton seed oil.
The bionic sebum composition comprises 5 parts of glass chicory seed oil, 8 parts of glass chicory seed oil, 10 parts of glass chicory seed oil, 12 parts of glass chicory seed oil, 15 parts of glass chicory seed oil, 18 parts of glass chicory seed oil or 20 parts of glass chicory seed oil.
The bionic sebum composition comprises 5 parts of evening primrose oil, 8 parts of evening primrose oil, 10 parts of evening primrose oil, 12 parts of evening primrose oil, 15 parts of evening primrose oil, 18 parts of evening primrose oil or 20 parts of evening primrose oil.
The bionic sebum composition comprises 1 part of tea seed oil, 2 parts of tea seed oil, 3 parts of tea seed oil, 5 parts of tea seed oil, 8 parts of tea seed oil, 10 parts of tea seed oil, 12 parts of tea seed oil, 15 parts of tea seed oil, 18 parts of tea seed oil or 20 parts of tea seed oil.
The bionic sebum composition comprises 0.5 part of pepper fruit oil, 1 part of pepper fruit oil, 2 parts of pepper fruit oil, 3 parts of pepper fruit oil, 4 parts of pepper fruit oil, 5 parts of pepper fruit oil, 6 parts of pepper fruit oil, 7 parts of pepper fruit oil, 8 parts of pepper fruit oil, 9 parts of pepper fruit oil or 10 parts of pepper fruit oil.
Further preferably, the bionic sebum composition comprises the following components in parts by weight:
1-10 parts of grass cotton seed oil
10-20 parts of glass chicory seed oil
10-20 parts of evening primrose oil
1-15 parts of tea seed oil
1-6 parts of pepper fruit oil.
Preferably, the mass ratio of the glass chicory seed oil to the evening primrose oil is (1-2): 1. such as: the mass ratio of the glass chicory seed oil to the evening primrose oil is 1: 1; the mass ratio of the glass chicory seed oil to the evening primrose oil is 1.2: 1; the mass ratio of the glass chicory seed oil to the evening primrose oil is 1.5: 1; the mass ratio of the glass chicory seed oil to the evening primrose oil is 1.8: 1; the mass ratio of the glass chicory seed oil to the evening primrose oil is 2: 1. the witloof seed oil and the evening primrose oil are rich in linoleic acid, gamma-linolenic acid and the like, are similar in composition and efficacy, and have good eliminating capacity on superoxide radical. Generally, one of the two ingredients is selected from cosmetics, and the two ingredients can be used alternatively. However, the inventor finds that the two are used together, and when the dosage is controlled, the antioxidant capacity of the skin can be further improved, and the skin barrier repair is facilitated.
Preferably, the biomimetic sebum composition further comprises at least one of squalane, lecithin or cholesterol. The addition of squalane, lecithin and cholesterol can further reduce the loss of water and lipid substances.
Preferably, the squalane is 0.5 to 10 parts by weight. Such as 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts.
Preferably, the lecithin is 0.5-10 parts by weight. Such as 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts.
Preferably, the cholesterol is 0.5 to 10 parts by weight. Such as 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and 10 parts.
Preferably, the biomimetic sebum composition further comprises at least one of meadowfoam seed oil, phytosterol oleate, ceramide, vitamin E or hydrogenated polyisobutene. The addition of the meadowfoam seed oil, the phytosterol oleate, the ceramide, the vitamin E and the hydrogenated polyisobutene can further reduce the loss of water and lipid substances, and can brighten the skin and achieve the effects of whitening and nourishing.
Preferably, the amount of the meadowfoam seed oil is 5-20 parts by weight; more preferably, the white Potentilla seed oil accounts for 10-20 parts by weight.
Preferably, the phytosterol oleate accounts for 1-5 parts by weight; further preferably, the phytosterol oleate accounts for 1-3 parts by weight.
Preferably, the ceramide is 0.1 to 3 parts by weight; further preferably, the ceramide is 0.1 to 1 part by weight.
Preferably, the vitamin E accounts for 0.5 to 3 parts by weight; further preferably, the vitamin E is 0.5 to 1 part by weight.
Preferably, the hydrogenated polyisobutene is from 0.5 to 5 parts by weight; further preferably, the hydrogenated polyisobutene is from 1 to 5 parts by weight.
In a second aspect, the present invention provides a method of preparing a biomimetic sebum composition for skin barrier repair.
Specifically, the preparation method of the bionic sebum composition for skin barrier repair comprises the following steps:
and mixing the grass cotton seed oil, the glass chicory seed oil, the evening primrose oil, the tea seed oil and the pepper fruit oil to prepare the bionic sebum composition.
In a third aspect the invention provides the use of a biomimetic sebum composition for skin barrier repair.
In particular to the application of the bionic sebum composition for skin barrier repair in cosmetics.
Preferably, the cosmetic is any one of essential oil, cream or lotion.
Preferably, the biomimetic sebum composition is added in an amount of 0.1 wt% to 25 wt% in the cosmetic. The addition amount of the bionic sebum composition is determined according to the type of the cosmetic. Generally, the addition amount in the essential oil is 3 to 25 weight percent; the addition amount of the cream and the emulsion is 1 to 15 weight percent.
In a fourth aspect, the invention provides a cream comprising the biomimetic sebum composition for skin barrier repair.
Preferably, the cream further comprises cetearyl glucoside, cetearyl alcohol, tocopherol acetate, sodium hyaluronate, xanthan gum and carbomer.
Preferably, the cream further comprises pentaerythritol tetra (ethyl hexanoate), glycerin, and polydimethylsiloxane.
Preferably, the cream further comprises 1, 3-butanediol, hexanediol and p-hydroxyacetophenone.
Further preferably, the cream comprises, by mass, 1-10 parts of the bionic sebum composition for skin barrier repair, 5-10 parts of pentaerythritol tetra (ethyl hexanoate), 1-10 parts of glycerol, 1-3 parts of polydimethylsiloxane, 1-3 parts of cetearyl glucoside, 1-3 parts of cetearyl alcohol, 1-3 parts of tocopherol acetate, 0.1-0.5 part of sodium hyaluronate, 0.1-0.5 part of xanthan gum, 0.5-3 parts of 1, 3-butanediol, 0.1-0.5 part of hexanediol, 0.1-0.5 part of p-hydroxyacetophenone, 0.1-0.3 part of carbomer and 60-80 parts of deionized water.
Compared with the prior art, the invention has the following beneficial effects:
the bionic sebum composition for skin barrier repair comprises grass cotton seed oil, glass chicory seed oil, evening primrose oil, tea seed oil and pepper fruit oil. The glass chicory seed oil and the evening primrose oil are rich in linoleic acid and gamma-linolenic acid and have good eliminating capacity on superoxide radical; and the grass cotton seed oil, the tea seed oil and the pepper fruit oil are compounded, so that the oxidation resistance of the bionic sebum composition can be improved, and the skin repairing capability can be improved. Meanwhile, the pepper fruit oil is rich in volatile oil, piperine, crude fat and various amide compounds, and can promote the osmotic absorption of nutrient substances; the grass cotton seed oil and the tea seed oil can play a role in astringing after the skin absorbs nutrient components, and inhibit harmful microorganisms from interfering the skin. The five components are used together, so that the skin absorption can be promoted, the skin barrier can be repaired, the oxidation resistance of the skin can be improved, and the loss of water and lipid substances can be reduced.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples are given for illustration. It should be noted that the following examples are not intended to limit the scope of the claimed invention.
The grass cotton seed oil used in the following examples or comparative examples was purchased from Jiangxi Hai Lin spices GmbH, Cichorium hybridum seed oil was purchased from supplier BOC Sciences, Oenothera biennis oil was purchased from Wohuana Tech GmbH, tea seed oil was purchased from Beijing Lingbao Techh GmbH, and Piper nigrum oil was purchased from Green-sourced Natural perfume oil refineries in Qingyuan region of Jian city. Other starting materials, reagents or equipment may be obtained from conventional commercial sources or may be obtained by known methods in the art, unless otherwise specified.
Example 1
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
5 parts of grass cotton seed oil;
15 parts of glass chicory seed oil;
15 parts of evening primrose oil;
8 parts of tea seed oil;
3 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Example 2
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
5 parts of grass cotton seed oil;
20 parts of glass chicory seed oil;
10 parts of evening primrose oil;
8 parts of tea seed oil;
3 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Example 3
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
5 parts of grass cotton seed oil;
10 parts of glass chicory seed oil;
20 parts of evening primrose oil;
8 parts of tea seed oil;
3 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Example 4
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
10 parts of grass cotton seed oil;
10 parts of glass chicory seed oil;
10 parts of evening primrose oil;
10 parts of tea seed oil;
6 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Example 5
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
2 parts of grass cotton seed oil;
20 parts of glass chicory seed oil;
20 parts of evening primrose oil;
3 parts of tea seed oil;
8 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Example 6
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
5 parts of grass cotton seed oil;
15 parts of glass chicory seed oil;
15 parts of evening primrose oil;
8 parts of tea seed oil;
3 parts of pepper fruit oil;
3 parts of squalane;
3 parts of lecithin;
1 part of cholesterol;
0.3 part of ceramide;
3 parts of hydrogenated polyisobutene.
The components are uniformly mixed to prepare the bionic sebum composition.
Example 7
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
5 parts of grass cotton seed oil;
15 parts of glass chicory seed oil;
15 parts of evening primrose oil;
8 parts of tea seed oil;
3 parts of pepper fruit oil;
3 parts of squalane;
3 parts of lecithin;
1 part of cholesterol;
0.1 part of ceramide;
3 parts of hydrogenated polyisobutene;
0.5 part of vitamin E;
10 parts of meadowrue root oil.
The components are uniformly mixed to prepare the bionic sebum composition.
Comparative examples 1 to 5
Comparative examples 1-5 each contained only one component, as shown in Table 1.
TABLE 1
| Group of | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Components | Seed oil of grass cotton | Chicory seed oil | Evening primrose oil | Tea seed oil | Pepper fruit oil |
Comparative example 6
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
17 parts of chicory seed oil;
17 parts of evening primrose oil;
9 parts of tea seed oil;
3 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Comparative example 7
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
7 parts of grass cotton seed oil;
25 parts of evening primrose oil;
10 parts of tea seed oil;
4 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Comparative example 8
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
7 parts of grass cotton seed oil;
25 parts of chicory seed oil;
10 parts of tea seed oil;
4 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Comparative example 9
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
6 parts of grass cotton seed oil;
18 parts of chicory seed oil;
18 parts of evening primrose oil;
4 parts of pepper fruit oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Comparative example 10
A bionic sebum composition for skin barrier repair comprises the following components in parts by weight:
6 parts of grass cotton seed oil;
16 parts of glass chicory seed oil;
16 parts of evening primrose oil;
8 parts of tea seed oil;
the components are uniformly mixed to prepare the bionic sebum composition.
Application example 1
A cream comprises, by mass, 5 parts of the biomimetic sebum composition prepared in example 1, 8 parts of pentaerythritol tetra (ethyl hexanoate), 7 parts of glycerol, 3 parts of polydimethylsiloxane, 3 parts of cetearyl glucoside, 2 parts of cetearyl alcohol, 2 parts of tocopherol acetate, 0.2 part of sodium hyaluronate, 0.2 part of xanthan gum, 2 parts of 1, 3-butanediol, 0.5 part of hexanediol, 0.5 part of p-hydroxyacetophenone, 0.2 part of carbomer, and 66.4 parts of deionized water.
Application example 2
Application example 2 is different from application example 1 in that the biomimetic sebum composition prepared in example 1 was replaced with the biomimetic sebum composition prepared in example 2, and the remaining components were the same as application example 1.
Application example 3
Application example 3 is different from application example 1 in that the biomimetic sebum composition prepared in example 3 is used instead of the biomimetic sebum composition prepared in example 1, and the rest components are the same as application example 1.
Application example 4
Application example 4 is different from application example 1 in that the biomimetic sebum composition prepared in example 4 was used instead of the biomimetic sebum composition prepared in example 1, and the rest of the components were the same as application example 1.
Application example 5
Application example 5 is different from application example 1 in that the biomimetic sebum composition prepared in example 5 was used instead of the biomimetic sebum composition prepared in example 1, and the rest of the components were the same as application example 1.
Application example 6
Application example 6 is different from application example 1 in that the biomimetic sebum composition prepared in example 6 is used instead of the biomimetic sebum composition prepared in example 1, and the rest components are the same as application example 1.
Application example 7
Application example 7 is different from application example 1 in that the biomimetic sebum composition prepared in example 7 was used instead of the biomimetic sebum composition prepared in example 1, and the rest of the components were the same as application example 1.
Comparative application examples 1 to 5
The bionic sebum compositions prepared in the comparative examples 6 to 10 were respectively used to prepare a cream, and the amounts and the remaining components were the same as in application example 1.
Product effectiveness testing
1. Acute skin irritation test
34 SPF-grade white rabbits (divided into 17 groups) were selected as test animals (purchased from the center of laboratory animals of Sichuan university) and the back hairs of the test animals were cut off to a range of 3 cm × 3 cm. The bionic sebum compositions prepared in examples 1 to 7 and comparative examples 6 to 10 and 0.5g of each of the single components in comparative examples 1 to 5 were applied to the unhaired skin of the test animal, and fixed with a non-irritating adhesive tape for 2 hours. The test composition was removed from the skin of the test animal and the skin reaction was continuously observed at the site of contact of the test animal with the composition.
The test results show that after 72 hours, no erythema or redness appeared on the skin of each test animal, and it was preliminarily judged that under the test conditions, the biomimetic sebum compositions prepared in examples 1-7 and comparative examples 6-10, and the single components in comparative examples 1-5 were all non-irritating according to the skin irritation intensity classification.
2. Oxidation resistance test
(1) Determination of superoxide anion radical scavenging ability
The biomimetic sebum compositions of examples 1-5 and comparative examples 6-10 were taken and tested on the individual components of comparative examples 1-5 (i.e., the samples to be tested). The specific determination method is as follows:
0.05mol/L of Tris-HCl buffer (4.5 mL) with pH 8.2 was preheated in a water bath at 25 ℃ for 20 min. Then adding 1mL of sample to be detected and 0.4mL of 25mmol/L pyrogallol solution, mixing uniformly, reacting for 5min in a water bath at 25 ℃, and adding 1.0mL of 8mol/L hydrochloric acid to terminate the reaction. Absorbance at 299nm with Tris-HCl buffer as referenceValue A 2 。
Blank control experiment: only 1mL of ethanol was used in place of the test sample, and the other steps were not changed. Absorbance A at 299nm 1 。
The superoxide anion radical scavenging ratio was calculated as follows:
for superoxide anion radical clearance (%) - [1- (A) 2 /A 1 )]×100％
(2) Determination of the scavenging ability of hydroxyl radicals
The biomimetic sebum compositions of examples 1-5 and comparative examples 6-10 were taken and tested on the individual components of comparative examples 1-5 (i.e., the samples to be tested). The specific test method is as follows:
3mL of FeSO with the concentration of 2mmol/L are sequentially added into a 25mL colorimetric tube 4 3mL of H with a concentration of 1mmol/L 2 O 2 Shaking, adding 3mL of salicylic acid 6mmol/L, shaking, heating in 37 deg.C water bath for 15min, taking out, and measuring absorbance A 1 ；
Adding samples to be tested with certain concentration, shaking, heating in water bath for 15min, taking out, and measuring absorbance A 2 。
Blank control experiment: only 1mL of ethanol is used for replacing the sample to be tested, and other steps do not change A 3 。
The clearance rate of the hydroxyl free radical is calculated according to the following formula:
(A) clearance of hydroxyl radical (%) - 3 -A 2 )/A 1 ×100％。
The test results are shown in table 2.
TABLE 2
As can be seen from table 2, compared with the comparative example, the biomimetic sebum composition provided by the invention has higher superoxide anion radical clearance rate and hydroxyl radical clearance rate, has excellent oxidation resistance, and can repair skin barrier and improve skin oxidation resistance.
3. Skin hydration test
The creams prepared in application examples 1 to 7 and comparative application examples 1 to 5 were subjected to a moisture content test of the horny layer of cheek skin, and the test instrument was a moisture content meter (Corneometer) of the horny layer of skin. The specific test method comprises the following steps: each group of face cream was tried by 35 healthy women (age 28-35 years). The cream is applied to cheek within 3 min after washing face every day without using other skin care products. Before and after the cream is used for four weeks, the moisture content of the horny layer of the cheek skin is tested by an instrument for 3 times in parallel, and the moisture content value of the horny layer is recorded by taking an average value.
Wherein, the change rate is relative to the change rate before use, and the calculation formula is as follows:
delta after four weeks is T 4 -T 0 ；
Water content change rate of horny layer (T) 4 -T 0 )/T 0 ×100％；
In the formula, T 0 -stratum corneum moisture content value before application of cream to the test area;
T 4 the stratum corneum moisture content value after four weeks of application of the cream to the test area.
The higher the skin moisture content, the better the skin moisturizing properties and the better the skin barrier function. The comparative example is obviously different from the embodiment, and meanwhile, the skin barrier repairing composition has a good moisturizing effect. The test results are shown in Table 3.
TABLE 3
As can be seen from table 3, compared with the comparative application example, the cream provided by the application example of the present invention can effectively repair the skin barrier, and has excellent moisturizing and moisturizing effects. The cream of application example 7 is the best in effect, because the components in application example 7 are the most, and squalane, lecithin, cholesterol, ceramide, hydrogenated polyisobutene, vitamin E and meadowfoam seed oil are also contained on the basis of application example 1. It is more similar in composition to sebum of the skin. However, as is clear from application example 1, the cream in application example 1 does not contain these components, but the rate of change in moisture content of the stratum corneum after use is not so great as in application example 7, and therefore, in the present invention, the grass-cotton seed oil, the glass-chicory seed oil, the evening primrose oil, the tea seed oil, and the pepper fruit oil play a more important role in repairing the skin barrier and improving the skin moisture retention. The cream of comparative application example 5 is the worst in effect, and the main reason is that the cream does not contain pepper fruit oil, has weak penetration effect, and the rest components cannot well penetrate into the skin, so that the repair effect is weak.
Claims (10)
1. A biomimetic sebum composition comprising the following components: grass cotton seed oil, glass chicory seed oil, evening primrose oil, tea seed oil and pepper fruit oil.
2. The biomimetic sebum composition of claim 1, wherein the biomimetic sebum composition comprises the following components in parts by weight:
1-15 parts of grass cotton seed oil
5-20 parts of glass chicory seed oil
5-20 parts of evening primrose oil
1-20 parts of tea seed oil
0.5-10 parts of pepper fruit oil.
3. A biomimetic sebum composition according to claim 2, wherein the mass ratio of the chicory seed oil to the evening primrose oil is (1-2): 1.
4. the biomimetic sebum composition of claim 1 or 2, further comprising at least one of squalane, lecithin, or cholesterol.
5. The biomimetic sebum composition according to claim 4, wherein the squalane is present in an amount of 0.5 to 10 parts by weight; 0.5-10 parts of lecithin; 0.5-10 parts of cholesterol.
6. The biomimetic sebum composition of claim 4, further comprising at least one of meadowfoam seed oil, phytosterol oleate, ceramide, vitamin E, or hydrogenated polyisobutene.
7. A method of preparing a biomimetic sebum composition according to any of claims 1-6, comprising the steps of:
and mixing the grass cotton seed oil, the glass chicory seed oil, the evening primrose oil, the tea seed oil and the pepper fruit oil to prepare the bionic sebum composition.
8. Use of a biomimetic sebum composition according to any of claims 1-6 in a cosmetic product.
9. The use according to claim 8, wherein the cosmetic is any one of essential oils, creams or lotions; the addition amount of the bionic sebum composition in the cosmetic is 0.1-25 wt%.
10. A cream characterized in that it comprises a biomimetic sebum composition according to any of claims 1-6.
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| CN115844763A (en) * | 2022-10-10 | 2023-03-28 | 广州市小谭科技有限公司 | Bionic barrier repair emulsion and preparation method thereof |
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| CN115804743B (en) * | 2022-12-27 | 2024-02-23 | 广州环亚化妆品科技股份有限公司 | Scalp sebum bionic composition and preparation method and application thereof |
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