CN110013445A - A kind of bionical sebum composition for skin barrier reparation - Google Patents
A kind of bionical sebum composition for skin barrier reparation Download PDFInfo
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- CN110013445A CN110013445A CN201910216769.XA CN201910216769A CN110013445A CN 110013445 A CN110013445 A CN 110013445A CN 201910216769 A CN201910216769 A CN 201910216769A CN 110013445 A CN110013445 A CN 110013445A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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Abstract
The invention discloses a kind of bionical sebum compositions for skin barrier reparation, according to parts by weight, including following components: 70-90 parts of white pond flower seed oil, 5-15 parts of saualane, 1-3 parts of phytosterols oletate, -4 parts of Cer EOS, 1-3 parts of lecithin, 1-3 parts of cholesterol, 0.1-0.8 parts of vitamin E, 0.1-0.7 parts of isooctadecanol.Products of the present invention is free of harmful industrial chemicals, and ingredient is close with human skin component, has supplement sebum, repairs skin damage barrier, in cosmetics or medical product.
Description
Technical field
The present invention relates to a kind of compositions, and in particular to a kind of bionical sebum composition for skin barrier reparation.
Background technique
With the improvement of people's living standards, people focus more on the nursing of skin.Safeguard the normal barrier function of skin
It is basis and the important component of skin nursing of skin nursing.Environmental pollution, hormonal readiness fluctuation, physical condition, outside
The factors such as boundary's stimulation are likely to that different degrees of skin barrier is caused to damage, and skin barrier is damaged and is easy to cause various skins
Disease.Therefore it needs to prevent skin barrier function damage, to take timely measure recovery barrier once skin barrier occurs and is damaged
Function.
Currently, people's daily use chemicals cleaning supplies used in everyday cause the sebum of skin surface excessively to be cleaned, and then cause
Skin surface sebum reduces and human body itself sebaceous glands is promoted to reinforce secretion, so requiring supplementation with for most of crowds
Certain sebum ingredient makes skin restore gloss and barrier function.Contain mineral mostly in existing bionical sebum substrate products
The raw material from petroleum, coal tar such as oil, synthetic dyestuff, compound essence or chemical preservative, these chemical raw materials have skin
Irritating effect.
Therefore it provides the non-stimulated bionical sebum composition of a kind of pair of skin come repair that skin barrier function extremely has must
It wants.
Summary of the invention
In view of the shortcomings of the prior art, the present invention provides a kind of bionical sebum composition for skin barrier reparation.It is described
Bionical sebum composition component is close with human sebaceous's component, can simulate sebum composition, repair damaged skin barrier, make skin
It gets well and dynamic.Bionical sebum composition of the present invention is without side-effects to human body, also non-stimulated to skin.Together
When, it can supplement because of sebum deficiency caused by excessively cleaning, restore smegma function, skin is allowed to restore natural gloss and barrier
Function, moreover it is possible to promote bioactivity and Medicated Permeation into internal, performance effect.
In addition, the present invention also provides a kind of preparation method of bionical sebum composition for skin barrier reparation, the party
Method is easy to operate, harmless.
A kind of bionical sebum composition for skin barrier reparation, according to parts by weight, including following components:
Preferably, a kind of bionical sebum composition for skin barrier reparation, according to parts by weight, including with the following group
Point:
It is further preferred that a kind of bionical sebum composition for skin barrier reparation, according to parts by weight, including with
Lower component:
Preferably, the ceramide is selected from Cer EOS, Cer NS, Cer NP, ceramide 4 or nerve
At least one of amide 6 II.
Optionally, the vitamin E can be substituted with vitamin e derivative.
Optionally, the vitamin E can be substituted with tocopherol.
A kind of preparation method of the bionical sebum composition for skin barrier reparation, comprising the following steps:
(1) each component is weighed by formula ratio, white pond flower seed oil, saualane, phytosterols oletate and ceramide is mixed
It closes, is put into constant-temperature heating magnetic stirring apparatus (Shanghai Hu Xi Industrial Co., Ltd. provides, model 85-2W), it is (excellent at 55-80 DEG C
Select 70 DEG C) at a temperature of be heated to being completely dissolved, be made mixed raw material A；
(2) lecithin, cholesterol, vitamin E are mixed, being put into constant-temperature heating magnetic stirring apparatus, (the analysis industry of Shanghai Shanghai has
Limit company provides, model 85-2W), 85-100 DEG C (preferably 90 DEG C) at a temperature of be heated to being completely dissolved, it is former that mixing is made
Expect B；
(3) mixed raw material A and mixed raw material B is mixed under 70-100 DEG C (preferably 85 DEG C), is dropped after mixing
Temperature adds isooctadecanol, is stirred for 40-50 DEG C (preferably 45 DEG C), is then cooled to 15-25 DEG C (preferably 20 DEG C), system
Obtain the bionical sebum composition.
A kind of application of the bionical sebum composition for skin barrier reparation, the bionical sebum composition are applied to system
In standby medical product (such as mucocutaneous external drug) and/or cosmetics.Wherein the dosage form of mucocutaneous external drug includes
But it is not limited to paste, patch, liniment, spray, suppository；Cosmetics include but is not limited to: cleaning, protection, nutrition, whitening, anti-ageing
It waits for a long time skin cosmetic；The hair-dressing cosmetics such as hair washing, hair care, hair dyeing, hair-waving；Toothpaste, the oral cavities such as mouthwash are used with health
Product；The cosmetics such as foundation cream, blush, eyebrow pencil, eye shadow, mascara, eyeliner, eye-liner；Sun-proof, nti-freckle, deodorization, depilation etc.
Special efficacy cosmetics.
Bionical sebum composition of the invention does efficient polyphenoils with white pond flower seed oil, and white pond flower seed oil is due to containing
98% or more the long chain fatty acids with oxidation resistant effect can reduce the oxidation of lipid and effectively extend bionical sebum combination
The pot-life of object.Meanwhile white pond flower seed oil or a kind of excellent emollients, the quality of bionical sebum composition can be made more
Add soft and moist, user is allowed to possess comfortable skin sense.Ceramide is dissolved using different hard ester alcohol, ceramide can be made to be easier to add
In the formula system for adding nearly cosmetics, the moistening effect of product is greatlyd improve.
Compared with the prior art, this product has the beneficial effect that:
(1) bionical sebum composition of the invention is chosen and the natural group split-phase in skin texture according to bionics principle
As ingredient, form mucocutaneous external preparation.Bionical sebum composition of the invention can replace existing external preparation
In by the industrial chemicals constituent such as petroleum, coal tar, avoid harm of the skin by industrial chemicals.
(2) bionical sebum composition of the invention can be supplemented because of sebum deficiency caused by excessively cleaning, and restore sebaceous glands
Secreting function allows skin to restore natural gloss and barrier function, moreover it is possible to promote biological active matter and Medicated Permeation into internal, performance
The effect of should having.
(3) bionical sebum composition of the invention, ingredient origin is natural, non-stimulated to skin, environmentally protective.
Specific embodiment
In order to allow those skilled in the art more to understand technical solution of the present invention, now enumerates following embodiment and said
It is bright, it should be pointed out that following embodiment does not constitute a limitation effect to the scope of protection of present invention.
Embodiment 1:
A kind of bionical sebum composition for skin barrier reparation, component meter, including following components by weight:
A kind of preparation method of the bionical sebum composition for skin barrier reparation, comprising the following steps:
(1) each component is weighed by formula ratio, white pond flower seed oil, saualane, phytosterols oletate and Cer NS is mixed
It closes, constant-temperature heating magnetic stirring apparatus (Shanghai Hu Xi Industrial Co., Ltd. provides, model 85-2W) is put into, in 65 DEG C of temperature
Under be heated to being completely dissolved, be made mixed raw material A；
(2) lecithin, cholesterol, vitamin E are mixed, being put into constant-temperature heating magnetic stirring apparatus, (the analysis industry of Shanghai Shanghai has
Limit company provide, model 85-2W), 85 DEG C at a temperature of be heated to being completely dissolved, be made mixed raw material B；
(3) mixed raw material A and mixed raw material B are mixed at 90 DEG C, are cooled to 40 DEG C after mixing, add
Isooctadecanol is stirred for, and is then cooled to 25 DEG C, and the bionical sebum composition is made.
Embodiment 2:
A kind of bionical sebum composition for skin barrier reparation, component meter, including following components by weight:
A kind of preparation method of the bionical sebum composition for skin barrier reparation, comprising the following steps:
(1)) weigh each component by formula ratio, by white pond flower seed oil, saualane, phytosterols oletate, Cer NP and
Ceramide 4 mixes, and is put into constant-temperature heating magnetic stirring apparatus (Shanghai Hu Xi Industrial Co., Ltd. provides, model 85-2W),
It is heated to being completely dissolved at a temperature of 70 DEG C, mixed raw material A is made；
(2) lecithin, cholesterol, vitamin E are mixed, being put into constant-temperature heating magnetic stirring apparatus, (the analysis industry of Shanghai Shanghai has
Limit company provide, model 85-2W), 85 DEG C at a temperature of be heated to being completely dissolved, be made mixed raw material B；
(3) mixed raw material A and mixed raw material B are mixed at 95 DEG C, are cooled to 50 DEG C after mixing, add
Isooctadecanol is stirred for uniformly, being cooled to 20 DEG C, the bionical sebum composition being made.
Comparative example 1
Compared with Example 2, white pond flower seed oil, other components and preparation process and 2 phase of embodiment are not contained in comparative example
Together.
Comparative example 2
Be added 30 parts of saualanes according to parts by weight compared with embodiment 1 and comparative example, in comparative example 2, other components with
Preparation process is same as Example 1.
By bionical sebum composition obtained by embodiment 1-2, physical and chemical index detection is carried out, physical and chemical index standard is shown in Table 1, physics and chemistry
Index the results are shown in Table 2.
Table 1:
| Inspection project | Test basis | Criterion |
| PH value (25 DEG C) | QB/T2872-2017 | 4.0-8.5 |
Table 2:
| Serial number | Inspection result | Individual event evaluation |
| Embodiment 1 | 6.0 | It is qualified |
| Embodiment 2 | 6.4 | It is qualified |
Table 2 illustrates that embodiment 1-2 is complied with standard, to no skin irritation.
The product of embodiment 1-2 and comparative example 1-2 preparation and commercially available bionical sebum product are subjected to injury repair effect
Test: 300 people of volunteer (one full year of life at age 25-40) is randomly divided into 6 groups by the principle of parallel control, is respectively labeled as blank pair
According to group, embodiment group, comparative example group and commercial product group, 50 people/group, with 3 × 3cm of inboard arm2Place is to be washed using position
Only, using moisture of skin tester (German CK company provides, model C M825) and skin elasticity tester, (German CK company is mentioned
The case where testing skin moisture content and skin elasticity index respectively for model MPA580) is tested and is wiped with 50% ethanol solution
5min is wiped, embodiment group, comparative example group and commercial product group smear embodiment 1-2, comparative example after standing 15min indoors respectively
The sample of 1-2 and commercial product, are tested immediately, then after 1h, after 2h, are tested 1 time respectively again after 5h, are observed trial effect.
Blank control group personnel are without any processing after having been wiped with 50% ethanol solution, equally after 1h, after 2h, test respectively after 5h
1 time, observation of nature repairing effect.Wherein ethyl alcohol can be partly dissolved Stratum corneum lipids ingredient, destroy original structure, lead to barrier function
It can be impaired.Table 3 is the test result of each product, and wherein moisture restores normal number (hereinafter referred to as moisture), and elasticity restores normal
Number (hereinafter referred to as elastic)
Table 3:
As can be seen from Table 3, prepared in the volunteer of product using embodiment 1-2, moisture restore normal number and
Elasticity restores normal number and is apparently higher than volunteer's number using comparative example 1-2 and commercial product.Illustrate of the present invention
The skin barrier repairing performance of bionical sebum composition is more preferable.Therefore, bionical sebum composition of the present invention is used in skin
Impaired skin barrier can be more preferably repaired on skin faster.
Claims (8)
1. a kind of bionical sebum composition for skin barrier reparation, which is characterized in that according to parts by weight, including with the following group
Point:
2. bionical sebum composition according to claim 1, which is characterized in that according to parts by weight, including following components:
3. bionical sebum composition according to claim 1, which is characterized in that according to parts by weight, including following components:
4. bionical sebum composition according to any one of claim 1-3, which is characterized in that the ceramide is selected from
At least one of Cer EOS, Cer NS, Cer NP, ceramide 4 or Cer AP II.
5. a kind of method for preparing bionical sebum composition of any of claims 1-4, which is characterized in that including with
Lower step:
(1) each component is weighed by formula ratio, white pond flower seed oil, saualane, phytosterols oletate and ceramide is mixed, added
Mixed raw material A is made in heat of solution；
(2) lecithin, cholesterol, vitamin E are mixed, is dissolved by heating, mixed raw material B is made；
(3) isooctadecanol is added after mixed raw material A and mixed raw material B being mixed, is stirred for, cools down, is made described and imitates
Rawhide oil/fat composition.
6. according to the method described in claim 5, it is characterized in that, the temperature dissolved by heating in step (1) is 55-80 DEG C.
7. according to the method described in claim 5, it is characterized in that, the temperature dissolved by heating in step (2) is 85-100 DEG C.
8. a kind of application of bionical sebum composition described in any one of -4 according to claim 1, which is characterized in that described imitative
Rawhide oil/fat composition is applied to prepare in cosmetics and/or medical product.
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Cited By (11)
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|---|---|---|---|---|
| CN111557874A (en) * | 2020-04-29 | 2020-08-21 | 上海清轩生物科技有限公司 | Bionic skin barrier repairing composition containing camellia extract and application |
| CN112315819A (en) * | 2020-11-20 | 2021-02-05 | 烟台新时代健康产业日化有限公司 | Bionic skin lipid membrane compound and application thereof in soothing cosmetics |
| CN112932991A (en) * | 2020-12-31 | 2021-06-11 | 广州增城潮徽生物技术有限公司 | Phospholipid composition, preparation method thereof and scalp care solution containing same |
| CN113332181A (en) * | 2021-05-27 | 2021-09-03 | 上海北即电子商务有限公司 | Essential oil capable of repairing damaged sebum membrane and cuticle and preparation method thereof |
| CN113499284A (en) * | 2021-07-09 | 2021-10-15 | 上海北即电子商务有限公司 | Shampoo oil capable of purifying scalp hair follicles and preparation method thereof |
| CN113876633A (en) * | 2021-10-20 | 2022-01-04 | 杭州兰匠化妆品有限公司 | Natural vegetable fat compound formed by human body sebum lipid imitation and preparation method and application thereof |
| CN114796024A (en) * | 2022-04-14 | 2022-07-29 | 珠海金肽生物科技有限公司 | Bionic sebum composition for skin barrier repair and preparation method and application thereof |
| CN114848547A (en) * | 2022-04-21 | 2022-08-05 | 寒霜籽(上海)生物科技有限公司 | Leather lipid membrane composition with waxy breathable micro-channel and preparation method thereof |
| CN115737484A (en) * | 2022-11-21 | 2023-03-07 | 媞颂日化用品(广州)有限公司 | Bionic hair care composition with repairing effect and application thereof |
| CN115844763A (en) * | 2022-10-10 | 2023-03-28 | 广州市小谭科技有限公司 | Bionic barrier repair emulsion and preparation method thereof |
| CN117898969A (en) * | 2024-01-17 | 2024-04-19 | 宁波伯通伟达生物医药有限公司 | Ceramide composition with effects of repairing and thickening skin barrier and preparation method thereof |
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| CN111557874A (en) * | 2020-04-29 | 2020-08-21 | 上海清轩生物科技有限公司 | Bionic skin barrier repairing composition containing camellia extract and application |
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| CN111557874B (en) * | 2020-04-29 | 2022-01-04 | 上海清轩生物科技有限公司 | Bionic skin barrier repairing composition containing camellia extract and application |
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