CN115737484A - Bionic hair care composition with repairing effect and application thereof - Google Patents
Bionic hair care composition with repairing effect and application thereof Download PDFInfo
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- CN115737484A CN115737484A CN202211453323.7A CN202211453323A CN115737484A CN 115737484 A CN115737484 A CN 115737484A CN 202211453323 A CN202211453323 A CN 202211453323A CN 115737484 A CN115737484 A CN 115737484A
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- hair care
- bionic
- care composition
- hair
- biomimetic
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Landscapes
- Cosmetics (AREA)
Abstract
The invention provides a bionic hair care composition with a repairing effect and application thereof. The bionic hair care composition with the repairing effect comprises bionic lipid, wherein the bionic lipid simulates lipid in scalp cells and lipid in a water lipid membrane, the lipid state is more similar to that of the lipid state in a scalp barrier, when the hair care product containing the bionic lipid is applied to a human body, the effects in the aspects of moisturizing, relieving itching, removing dandruff, repairing hair quality and the like are good, and when the bionic lipid specifically comprises squalane, jojoba oil, butanediol dicaprylate/dicaprate, phytosterol oleate, tocopherol and ceramide, the effects in the aspects of moisturizing, relieving itching, removing dandruff, repairing hair quality and the like of the prepared hair care product are further enhanced.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to a bionic hair care composition with a repairing effect and application thereof.
Background
Hair is one of the important physiological characteristics of mammals, and the health and maintenance of hair is very important to the personal image. Hair can be divided into two parts, a hair shaft and a hair root, the hair root is responsible for the biosynthesis and directional growth of hair, and the hair shaft is the part exposed to the outside of the skin. The cross section of the hair shaft can be divided into a hair small skin, a cortex layer and a medulla layer, wherein the hair small skin and the cortex layer wrap the medulla, the hair small skin is at the outermost layer, and the cortex content in the three components is the most. In daily life, hair is often damaged to various degrees by environmental pollution, ultraviolet irradiation, chemical dyes or permanent wave agents, and the like.
The health of hair is closely related to the healthy ecological environment of scalp, scalp is the thinnest part of human skin, and the physiological environment of scalp such as sebum content, pH value and moisture content reflects the health degree of scalp. The scalp barrier structure is a brick wall structure and is composed of a sebum membrane, horny layer keratin, lipid, dermal mucopolysaccharide, mucopolysaccharide and the like. Biomimetic lipid technology mainly mimics the lipids between cells of the scalp and in the lipid membrane of the water. Intercellular lipids are mainly composed of ceramides, cholesterol and fatty acids. The lipid in the water lipid membrane mainly comprises squalene, linoleic acid, linolenic acid, triacylglycerol, etc. When the sebum secretion of the scalp is unbalanced, the scalp becomes greasy due to oil discharge; when the environment of scalp flora is unbalanced, a large amount of harmful bacteria are bred, and the phenomenon of scalp itch can occur; when the stratum corneum of the scalp is metabolized too rapidly, the desquamation can form macroscopic abnormal mass desquamation, namely dandruff. The scalp acts as the most important command control center-head natural barrier for the human body, being second to the eyelids in terms of fragility and sensitivity. The scalp is comprehensively, systematically and scientifically conditioned and maintained, scalp problems such as hair oil, dandruff, sensitivity, pruritus and the like can be fundamentally eliminated, and the health state of the scalp and the hair is maintained.
CN110585036A discloses a hair repair composition, which comprises the following components in percentage by mass: 0.5 to 5 percent of snow lotus juice; 1-5% of chicory root conditioner; 0.5 to 5 percent of green olive squalane; the balance of the solvent is 100 percent. The hair care product disclosed by the invention can be used for deeply repairing damaged hair without deposition by using natural conditioning and repairing components, and finally restoring the luster of the hair. Specifically, the hair restoration composition contains the components of the snow lotus juice, the green olive squalane and the chicory root conditioner, and can effectively restore damaged hair, smooth hair scales and restore luster of the hair.
CN111449991A discloses a hair restoration composition, a preparation method and an application thereof, wherein the hair restoration composition comprises the following raw material components: diphenyl dimethicone, argan oil, candida/glucose/rapeseed methyl oleate fermentation product, and bis-aminopropyl dimethicone. The beneficial effects of the invention are as follows: through compounding and reasonably proportioning 4 raw materials of diphenyl polydimethylsiloxane, argania spinosa kernel oil, candida/glucose/rapeseed methyl oleate fermentation products and bis-aminopropyl polydimethylsiloxane, on one hand, the hair can be helped to resist damage caused by ultraviolet rays, heat and the like and repair damaged hair scales, on the other hand, the hair brightness is improved, meanwhile, the hair is fresh and not greasy, the hair is enabled to be more smooth, and the dry-wet combing property of the hair is effectively improved. The invention provides a hair solution integrating functionality and practicability, raw materials are easy to obtain, and the preparation method is simple and suitable for popularization and application.
At present, the hair care and repair care product mostly contains hydrophobic components of bionic lipid, but hydrophilic active components and components of hair in the micro environment of the hair are ignored, so that the hair care and repair product which has comprehensive searching effect and is more consistent with the micro environment of the scalp is very significant.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a hair care composition and application thereof, and particularly provides a bionic hair care composition with a repairing effect and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a biomimetic hair care composition with restorative efficacy comprising biomimetic lipids including squalane, jojoba oil, butylene glycol dicaprylate/dicaprate, phytosterol oleate, tocopherols and ceramides.
The squalane can effectively form a natural protective film, help the balance between skin and sebum, and further strengthen the repairing effect of repairing the skin. Squalane is a lipid closest to the sebum of the scalp, has strong affinity, can be integrated with the sebum membrane of human body, and forms a natural barrier on the surface of the scalp. Squalane can also inhibit the peroxidation of scalp lipid, can effectively permeate into skin, can promote the proliferation of basal cells of scalp, and has obvious physiological effects of delaying the aging of scalp, and improving and eliminating chloasma. Squalane also can open scalp pores, promote blood microcirculation, promote cell metabolism, and help repair damaged cells.
The seeds of the jojoba plant are rich in liquid waxes and essential fatty acids and have moisturizing properties. Jojoba oil is used in shampoo and hair conditioner to help soften and restore the luster of hair. In addition, it can help alleviate scalp dryness and help control dandruff production. The jojoba oil also plays an important role in preventing hair from being sunburned, softening hair, blackening hair and preventing split ends.
The butanediol dicaprylate/dicaprate is prepared by esterifying medium-chain fatty acid and glycerol or other dihydric alcohol, and the butanediol dicaprylate/dicaprate is a completely esterified (low hydroxyl value) and highly refined product, so that the butanediol dicaprylate/dicaprate is applied to skin care products, has low irritation, good ductility, low viscosity and fresh and non-greasy skin feel.
The phytosterol oleate has the composition similar to scalp natural lipid, has good permeability to stratum corneum, has strong moisturizing effect, and can keep scalp surface moisture; has effects of relieving irritation, tranquilizing mind, and relieving inflammation, and has excellent effect in resisting pruritus; can help other components to be absorbed, and reduce scalp oily feeling.
The natural mixed tocopherol is a natural antioxidant extracted from edible vegetable oil, has various biological activities, can protect the stability of a cell membrane by interrupting the chain reaction of free radicals, and prevents lipofuscin on the membrane from forming to delay the aging of an organism; can regulate the metabolic activity of organisms to be performed orderly by maintaining the stability of genetic materials and preventing the structural variation of chromosomes, and also can play a role in delaying senescence; has effects in maintaining the elasticity of connective tissue, and promoting blood circulation; regulating normal secretion of hormones in vivo; controlling consumption of acid in vivo; the natural mixed tocopherol is applied to a head care product, can moisten and healthily scalp, can improve hair follicle microcirculation, ensures nutrition supply and regenerates hair.
Ceramide is an amide compound formed by dehydrating long-chain fatty acid and the amino group of sphingosine, and mainly comprises ceramide phosphorylcholine and ceramide phosphorylethanolamine, phospholipid is a main component of cell membranes, 40% -50% of sebum in horny layer is composed of ceramide, and ceramide is a main part of intercellular matrix and plays an important role in keeping moisture balance of horny layer. Ceramide has strong ability to associate water molecules, and can maintain skin moisture by forming a network structure in the horny layer, thereby contributing to scalp water-oil balance and dandruff reduction. Ceramides occur naturally in the cuticle of the hair, and thus the use of natural hair care products containing ceramides helps to improve the texture of the hair.
The bionic hair care composition with the repairing effect comprises bionic lipid, wherein the bionic lipid simulates lipid in scalp cells and lipid in a water lipid membrane, the lipid state is more similar to that of the lipid state in a scalp barrier, when the hair care product containing the bionic lipid is applied to a human body, the effects in the aspects of moisturizing, relieving itching, removing dandruff, repairing hair quality and the like are good, and when the bionic lipid specifically comprises squalane, jojoba oil, butanediol dicaprylate/dicaprate, phytosterol oleate, tocopherol and ceramide, the effects in the aspects of moisturizing, relieving itching, removing dandruff, repairing hair quality and the like of the prepared hair care product are further enhanced. The phytosterol oleate and the ceramide are matched for use, have synergistic interaction, and can improve the repairing effect of the bionic hair care composition with the repairing effect on the head skin and the hair.
Preferably, the bionic lipid comprises, by mass, 5-40 parts of squalane, 5-40 parts of jojoba oil, 5-30 parts of butanediol dicaprylate/dicaprate, 1-10 parts of phytosterol oleate, 1-20 parts of tocopherol and 0.1-3 parts of ceramide.
The squalane can be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts or 40 parts by weight;
the jojoba oil can be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts or 40 parts by weight;
the butanediol dicaprylate/dicaprate can be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts or 30 parts by weight;
the mass parts of the phytosterol oleate can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts and the like;
the mass portion of the tocopherol can be 1 portion, 4 portions, 7 portions, 10 portions, 13 portions, 16 portions, 19 portions or 20 portions;
the mass portion of the ceramide can be 0.1 portion, 0.5 portion, 1 portion, 1.5 portions, 2 portions, 2.5 portions or 3 portions;
other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the biomimetic hair care composition with restorative efficacy further comprises a biomimetic hair ingredient.
The bionic hair-care composition with the repairing effect also comprises a bionic hair component, wherein the bionic hair component is used for simulating the microenvironment of the head, and the bionic hair-care composition containing the bionic hair component has a stronger hair quality repairing effect.
Preferably, the biomimetic hair component comprises an amino acid component and/or hydrolysed keratin.
Preferably, the biomimetic hair component comprises an amino acid component and hydrolyzed keratin.
The amino acid component can maintain normal growth of collagen fiber and elastic fiber in hair, and maintain flexibility and normal growth of hair. The amino acids can regulate water acid-base balance and oil balance of scalp, enhance immunity of scalp, and improve anti-allergy ability of sensitive scalp.
Keratin is one of a family of fibrous structural proteins, which is the major protein that makes up hair, horns, paws and the outer layers of human skin. When hydrolysed keratin is used topically on the hair, it helps to fill the tiny spaces throughout the hair shaft, including the spaces in the medulla, cortex and cuticle. Filling these fine gaps with hydrolyzed keratin can enhance the strength of the hair and achieve the effect of repairing damaged hair.
When the bionic hair ingredient comprises the combination of the amino acid ingredient and the hydrolyzed keratin, the two ingredients are matched for use and have synergistic interaction, and the hair quality repairing effect of the prepared bionic hair care composition with the repairing effect is further improved.
Preferably, the amino acid component includes any one or a combination of at least two of glycine, alanine, leucine, isoleucine, valine, cystine, cysteine, methionine, threonine, serine, phenylalanine, tyrosine, tryptophan, proline, hydroxyproline, glutamic acid, or aspartic acid, the combination of at least two includes a combination of glycine and alanine, a combination of alanine and leucine, or a combination of leucine or isoleucine, and the like, and any other combination can be selected, which is not described in detail herein.
Preferably, the bionic hair component comprises 0.1-3 parts of amino acid component and 0.1-3 parts of hydrolyzed keratin by mass.
The amino acid component can be 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts by weight;
the mass portion of the hydrolyzed keratin can be 0.1 portion, 0.5 portion, 1 portion, 1.5 portions, 2 portions, 2.5 portions or 3 portions, etc.;
other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the biomimetic hair care composition with repair function further comprises a function auxiliary ingredient.
Preferably, the efficacy auxiliary component comprises any one or a combination of at least two of epigallocatechin gallate, centella asiatica extract or rosemary extract, the combination of at least two of the epigallocatechin gallate and the centella asiatica extract, the combination of the centella asiatica extract and the rosemary extract or the combination of the epigallocatechin gallate and the rosemary extract, and the like, and any combination mode can be selected, and is not repeated herein.
Preferably, the efficacy adjunct ingredient comprises a combination of epigallocatechin gallate, centella asiatica extract and rosemary extract;
epigallocatechin gallate has antibacterial and antiviral effects, and can also be used as stabilizer and antioxidant in cosmetics. Epigallocatechin gallate has strong antioxidant effect, and can delay oxidative deterioration of bionic lipid, bionic hair components and other raw materials, and prolong product shelf life. Epigallocatechin gallate is a direct androgen antagonist and can help inactivate DHT receptors and inhibit 5-alpha reductase to promote hair growth, can help prevent hair loss and help hair regrowth.
The centella asiatica extract contains active ingredients such as asiatic acid, madecassic acid, asiaticoside and madecassoside, and has good anti-allergy, antioxidant, whitening, moisturizing and repairing functions.
The rosemary extract contains active ingredients such as rosmanol, carnosol and carnosic acid, has strong antioxidant activity, can effectively remove free radicals and protect elastin in scalp cells, and the carnosic acid can inhibit the activity of hyaluronidase to avoid the degradation of hyaluronic acid.
When the efficacy auxiliary component comprises epigallocatechin gallate, a centella asiatica extract or a rosemary extract, the three components are matched with each other and used in a combined way, so that the efficacy is enhanced in the aspects of anti-inflammation, itching relieving and dandruff removing.
Preferably, the efficacy auxiliary component comprises any one or the combination of at least two of 0.01 to 0.2 portion of epigallocatechin gallate, 0.1 to 3 portions of centella asiatica extract or 0.1 to 3 portions of rosemary extract in portion by mass.
Epigallocatechin gallate can be added in an amount of 0.01, 0.03, 0.05, 0.07, 0.09, 0.11, 0.13, 0.15, 0.17, 0.19 or 0.2 parts by mass;
the mass parts of the centella extract can be 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts;
the mass portion of the rosemary extract can be 0.1 portion, 0.5 portion, 1 portion, 1.5 portion, 2 portions, 2.5 portions or 3 portions;
other specific values within the above ranges can be selected, and are not described in detail herein.
In a second aspect, the present invention provides a bionic hair care preparation with a repairing function, which is prepared from the raw material comprising the bionic hair care composition with a repairing function according to the first aspect.
The invention provides a bionic hair care preparation with a repairing effect, wherein the preparation raw materials of the preparation contain the bionic hair care composition with the repairing effect in the first aspect, and the preparation can achieve better effects of moisturizing, relieving itching, removing dandruff and repairing hair.
Preferably, the formulation is in the form of a serum, lotion, cream, gel, spray or liquid dressing.
The preparation of the preparation can be any one of hair care products, such as essence, emulsion, cream, gel, spray or liquid dressing.
In a third aspect, the invention provides a preparation method of a bionic hair care emulsion with a repairing effect, wherein the preparation method comprises the following steps:
(1) Preparing an oil phase, wherein the preparation raw materials of the oil phase comprise the hydrophobic component, the emulsifier and the emulsification aid in the bionic hair care composition with the repairing efficacy; preparing an aqueous phase;
(2) And (3) uniformly mixing the oil phase and the water phase, homogenizing and emulsifying, and adding the rest components of the bionic hair care composition with the repairing efficacy in the first aspect to prepare the bionic hair care emulsion with the repairing efficacy.
The preparation method of the bionic hair care emulsion with the repairing effect only needs to add the hydrophobic ingredients in the bionic hair care composition with the repairing effect into the preparation process of the oil phase, and add the rest ingredients of the bionic hair care composition with the repairing effect after the oil phase and the water phase are emulsified.
Preferably, the emulsifier in step (1) comprises any one or a combination of at least two of cetostearyl alcohol, glyceryl monostearate, self-emulsifying glyceryl monostearate, peregal O-25, cetearyl alcohol PEG-20, ceteareth-21 or vegetable alkyl glycoside, the combination of at least two of cetostearyl alcohol and glyceryl monostearate, the combination of glyceryl monostearate and self-emulsifying glyceryl monostearate, the combination of peregal O-25 and cetearyl alcohol PEG-20, and the like, and any other combination mode can be selected, which is not described in detail herein.
Preferably, the emulsification aid in step (1) includes any one or a combination of at least two of an osmotic agent, a pH adjusting agent or a thickening agent, where the combination of at least two includes a combination of an osmotic agent and a pH adjusting agent, a combination of a pH adjusting agent and a thickening agent, or a combination of an osmotic agent and a thickening agent, and any other combination mode can be selected, and is not repeated here.
Preferably, the penetrating agent comprises any one or combination of at least two of bisabolol, isosorbide dimethyl ether or inositol, the combination of at least two comprises the combination of bisabolol and isosorbide dimethyl ether, the combination of isosorbide dimethyl ether and inositol or the combination of bisabolol and inositol, and the like, and any other combination mode can be selected, so that the repeated description is omitted.
Preferably, the raw material for preparing the water phase in the step (1) comprises water;
preferably, the raw materials for preparing the water phase in the step (1) further comprise a film forming agent and/or an antistatic agent;
preferably, the film forming agent includes any one or a combination of at least two of hydroxyethyl cellulose, polyvinyl acetate, acrylate/octylacrylamide copolymer, cationic guar gum, cationic cellulose or polyvinyl alcohol, and the combination of at least two includes a combination of hydroxyethyl cellulose and polyvinyl acetate, a combination of polyvinyl acetate and acrylate/octylacrylamide copolymer, a combination of cationic guar gum and cationic cellulose or a combination of polyvinyl acetate and polyvinyl alcohol, and any other combination can be selected, and will not be described in detail herein.
Preferably, the antistatic agent comprises any one or a combination of at least two of behenyl trimethyl ammonium chloride, octadecyl trimethyl ammonium chloride, dialkyl dimethyl ammonium chloride, trialkyl methyl ammonium chloride or diquaternary ammonium salt, the combination of at least two of behenyl trimethyl ammonium chloride and octadecyl trimethyl ammonium chloride, behenyl trimethyl ammonium chloride and trialkyl methyl ammonium chloride or octadecyl trimethyl ammonium chloride and trialkyl methyl ammonium chloride, and the like, and any combination mode can be selected, and is not repeated here.
Preferably, the homogenizing and emulsifying time of the step (2) is 5-20min, and the temperature is 30-90 ℃.
Specific values in the 5-20min can be selected from 5min, 7min, 9min, 11min, 13min, 15min, 17min, 19min or 20min, and other specific values in the above numerical range can be selected, and are not described in detail herein.
The specific value of 30-90 ℃ can be 30 ℃, 40 ℃, 50 ℃, 60 ℃, 70 ℃, 80 ℃, or 90 ℃ and the like, and other specific values in the above numerical range can be selected, which is not described in detail herein.
In a fourth aspect, the present invention provides a bionic hair care composition with a repairing effect as described in the first aspect, a bionic hair care preparation with a repairing effect as described in the second aspect, or a bionic hair care emulsion with a repairing effect as described in the third aspect, and its use in preparing a hair care product
Compared with the prior art, the invention has the following beneficial effects:
1. the bionic hair care composition with the repairing effect comprises bionic lipid which simulates lipid in scalp cells and lipid in a water lipid membrane, is more similar to the lipid state in a scalp barrier, has good effects on moisturizing, relieving itching, removing dandruff, repairing hair quality and the like when a hair care product containing the bionic lipid is applied to a human body, and further enhances the effects on the aspects of moisturizing, relieving itching, removing dandruff, repairing hair quality and the like when the bionic lipid specifically comprises squalane, jojoba oil, butanediol dicaprylate/dicaprate, phytosterol oleate, tocopherol and ceramide. The phytosterol oleate and the ceramide are matched for use, have synergistic interaction, and can improve the repairing effect of the bionic hair care composition with the repairing effect on the head skin and the hair.
2. The invention provides a bionic hair care preparation with a repairing effect, wherein the preparation raw materials of the preparation contain the bionic hair care composition with the repairing effect in the first aspect, and the preparation can achieve better effects of moisturizing, relieving itching, removing dandruff and repairing hair quality.
3. The preparation method of the bionic hair care emulsion with the repairing effect only needs to add the hydrophobic ingredients in the bionic hair care composition with the repairing effect into the preparation process of the oil phase, and add the rest ingredients of the bionic hair care composition with the repairing effect after the oil phase and the water phase are emulsified.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitation of the present invention.
The procedures, conditions, reagents, experimental methods and the like for carrying out the present invention are general knowledge and common general knowledge in the art except for the contents specifically mentioned below, and the present invention is not particularly limited. The experimental procedures in each example, in which the specific conditions are not specified, are generally carried out under the conventional conditions or under the conditions recommended by the manufacturers.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The following examples, comparative examples, application examples, and application comparative examples relate to squalane which is a plant squalane product available from sunlight in Japan; jojoba oil is a gold jojoba oil product available from guangzhou 26201temporarily Biotech limited; butanediol dicaprylate/dicaprate is a product from MIGLYOL 8810, CREMER, germany; phytosterol oleate is a phytosterol ester product purchased from sienna biosciences ltd; the natural mixed tocopherol is a product which is purchased from cereal biotechnology limited of Fengyichun and has the model number of MPT-95; cetostearyl alcohol is a product purchased from thailaceae; bisabolol is a product purchased from beijing beililess biotechnology limited; glyceryl monostearate is a product from queen; hydroxyethyl cellulose is a product available from Dow, USA under the model CELLOSIZE QP-100; behenyltrimethylammonium chloride is a product sold under the name BTAC-228KC from Guangzhou Kongshi Co.Ltd; epigallocatechin gallate is a product purchased from Shaanxi Zeylang Biotechnology GmbH with model number 589456 of 90% epigallocatechin gallate; the hydrolyzed keratin is a product from Biotech limited, aomori, xian, and Aomori; the Complex Amino acids are products of Amino Acid Complex (B) purchased from bailander Bioland korea; ceramide-3 is a water-soluble ceramide product available from Guangzhou Biotechnology Ltd, model 20; the herba Centellae extract is herba Centellae extractive solution from Bo-palm chemical industry, inc. of Guangzhou city; the herba Rosmarini officinalis extractive solution is purchased from Gnxianzhou Baizhentang Biotech limited.
Example 1
This example provides a biomimetic hair care composition with restorative efficacy, comprising the ingredients shown in table 1:
TABLE 1
Example 2
This example provides a biomimetic hair care composition with restorative efficacy, comprising the ingredients shown in table 2:
TABLE 2
Example 3
This example provides a biomimetic hair care composition with restorative efficacy, comprising the ingredients shown in table 3:
TABLE 3
Example 4
This example provides a bionic hair care composition with repair efficacy, which is different from example 1 only in that no amino acid component is included in the components, and the mass parts of the amino acid component are allocated to hydrolyzed keratin, and the rest is the same as example 1.
Example 5
This example provides a bionic hair care composition with restoration efficacy, which is different from example 1 only in that hydrolyzed keratin is not included and is distributed to amino acid components in parts by mass, and the rest is the same as example 1.
Example 6
This example provides a biomimetic hair care composition with restoration efficacy, which is composed of the same components as in example 1 except that epigallocatechin gallate is not included, and the parts by weight of epigallocatechin gallate are proportionally distributed to centella asiatica extract and rosemary extract, and the rest is the same as in example 1.
Example 7
This example provides a biomimetic hair care composition with restoration efficacy, which is composed of the same components as in example 1 except that the asiatic pennywort herb extract is not included, and the mass portion of the asiatic pennywort herb extract is proportionally distributed into epigallocatechin gallate and rosemary extract, and the rest is the same as in example 1.
Example 8
This example provides a biomimetic hair care composition with restoration efficacy, which is the same as that in example 1 except that rosemary extract is not included, and the rosemary extract is proportionally distributed into epigallocatechin gallate and centella asiatica extract in parts by weight.
Example 9
This example provides a biomimetic hair care composition with restoration efficacy, which is different from the biomimetic hair care composition in example 1 only in that epigallocatechin gallate and centella asiatica extract are not included, and epigallocatechin gallate and centella asiatica extract are all distributed to rosemary extract in parts by mass, and the rest is the same as example 1.
Example 10
This example provides a biomimetic hair care composition with restoration efficacy, which is composed of the same components as in example 1 except that it does not contain centella asiatica extract and rosemary extract, and the centella asiatica extract and rosemary extract are all distributed into epigallocatechin gallate in parts by mass, and the rest is the same as in example 1.
Example 11
This example provides a biomimetic hair care composition with restoration efficacy, which is composed of the same components as in example 1 except that epigallocatechin gallate and rosemary extract are not included, and the parts by weight of the epigallocatechin gallate and the rosemary extract are all distributed to the centella asiatica extract, and the rest is the same as example 1.
Example 12
This example provides a biomimetic hair care composition with restoration efficacy, which is composed of the same components as in example 1 except that epigallocatechin gallate is not included, and parts by weight of epigallocatechin gallate is distributed to natural mixed tocopherols, and the rest is the same as in example 1.
Comparative example 1
This comparative example provides a bionic hair care composition with restoration efficacy, which is different from example 1 only in that ceramide-3 is not contained and the portion by mass of ceramide-3 is distributed to phytosterol oleate, and the rest is the same as example 1.
Comparative example 2
This comparative example provides a bionic hair care composition with restoration efficacy, which is different from example 1 only in that it does not contain phytosterol oleate, and the phytosterol oleate is distributed to ceramide-3 in parts by mass, and the rest is the same as example 1.
Comparative example 3
This comparative example provides a biomimetic hair care composition with restoration efficacy, which is different from example 1 only in that natural mixed tocopherols are not included, and the natural mixed tocopherols are distributed to epigallocatechin gallate in parts by mass, and the rest is the same as example 1.
Application example 1
The application example provides a bionic hair care emulsion with a repairing effect, and the preparation method of the bionic hair care emulsion with the repairing effect is as follows:
(1) Mixing squalane, jojoba oil, butanediol dicaprylate/dicaprate, phytosterol oleate and natural mixed tocopherols as described in example 1;
(2) Sequentially adding the mixture prepared in the step (1), 4 parts of hexadecadecanol, 0.1 part of bisabolol and 1 part of glyceryl monostearate into an oil phase pot, heating to 80 ℃, dissolving and uniformly stirring;
(3) Sequentially adding 0.3 part of hydroxyethyl cellulose and 1 part of behenyl trimethyl ammonium chloride into a water phase pot, adding water to make up 100 parts of the total weight of the emulsion, heating to 85 ℃ to dissolve, and stirring uniformly;
(4) Pumping the mixture in the water phase pot in the step (3) into a main pot, pumping the oil phase into the main pot while stirring, stirring and homogenizing for 10min, vacuumizing, slowly stirring and cooling to 40 ℃;
(5) And (5) adding the rest components (ceramide-3, amino acid components, hydrolyzed keratin, epigallocatechin gallate, centella asiatica extract and rosemary extract) in the bionic hair care composition with the repairing effect in the embodiment 1 into the mixture in the step (4), uniformly stirring, cooling to 35 ℃, and subpackaging to obtain the bionic hair care emulsion with the repairing effect.
Application examples 2 to 12
Application examples 2 to 12 provide a biomimetic hair care emulsion with repair efficacy, and the preparation method of the biomimetic hair care emulsion with repair efficacy is different from application example 1 only in that the biomimetic hair care composition with repair efficacy prepared in example 1 is replaced by the biomimetic hair care composition with repair efficacy prepared in examples 2 to 12, and the rest is the same as application example 1.
Application of comparative examples 1 to 3
Application comparative examples 1 to 3 provide a biomimetic hair care emulsion with a repairing effect, and the preparation method of the biomimetic hair care emulsion with the repairing effect is different from that of application example 1 only in that the biomimetic hair care composition with the repairing effect prepared in example 1 is replaced by the biomimetic hair care composition with the repairing effect prepared in comparative examples 1 to 3, and the rest is the same as that of application example 1.
Test example 1
Evaluation of anti-inflammatory Effect of biomimetic Hair Care composition having repairing Effect
RAW264.7 cells in logarithmic growth phase are plated on a 12-hole plate, cultured at 37 ℃ for 7h, then the culture medium is discarded, a basal medium containing 0.08 (v/v,%) of the composition of examples 1-3 and 6-11 is added for pretreatment for 1h, LPS with the final concentration of 100ng/mL is added for induction for 17h, and culture supernatants of each group of cells are collected and the NO content is detected. Wherein, blank group: without addition of composition and LPS, model group: LPS induced alone without the addition of composition, and 40. Mu.M dexamethasone was used as a positive control. The results are shown in Table 1. NO content difference = NO content of each example/NO content of model group × 100%.
TABLE 4
Group of | NO content Difference ratio (%) |
Example 1 | 75.6 |
Example 2 | 80.5 |
Example 3 | 77.1 |
Example 6 | 85.9 |
Example 7 | 81.3 |
Example 8 | 86.1 |
Example 9 | 89.8 |
Example 10 | 91.6 |
Example 11 | 88.2 |
Blank group | 46.3 |
Model set | 100.0 |
Positive control group | 66.8 |
NO is an important proinflammatory mediator, mediates the occurrence and development of various inflammatory reactions, and can inhibit the inflammatory reactions by reducing the content of NO, so that the anti-inflammatory effect is achieved. As can be seen from the data in Table 4, in examples 6-11, there is NO difference in the NO content of one or two of the epigallocatechin gallate, the centella asiatica extract and the rosemary extract, respectively, as compared to example 1, which indicates that there is NO difference in the NO content of the epigallocatechin gallate, the centella asiatica extract and the rosemary extract, and that the combination of the three components has synergistic effect in anti-inflammatory effect.
Test example 2
Evaluation of antioxidant Properties of biomimetic Hair Care composition with restorative efficacy
The compositions prepared in examples 1-3, 12 and comparative example 3 were evaluated for antioxidant properties by testing the removal efficiency of DPPH. The specific evaluation method comprises the following steps: 0.5g of the composition was immersed in 4mL of a DPPH (100. Mu.M in 99wt% ethanol) solution (using a DPPH-only solution as a control) and incubated in the dark for 60min. The absorbance value of the mixed solution at 517nm was then measured using an ultraviolet-visible spectrophotometer. Calculated using the following equation: DPPH clearance = (control absorbance-experimental absorbance)/control absorbance × 100%.
TABLE 5
Group of | DPPH clearance (%) |
Example 1 | 76.2 |
Example 2 | 64.3 |
Example 3 | 81.0 |
Example 12 | 55.7 |
Comparative example 3 | 49.2 |
As can be seen from the data in table 5, the biomimetic hair care composition with restoration efficacy of example 12 and comparative example 3 lack one of epigallocatechin gallate and natural mixed tocopherol, respectively, and the DPPH clearance rate is lower than that of example 1, indicating that the two components of epigallocatechin gallate and natural mixed tocopherol can synergistically enhance the antioxidant effect of the biomimetic hair care composition with restoration efficacy.
Test example 3
Evaluation of moisturizing, itching relieving and dandruff removing effects of bionic hair care emulsion with repairing effect
(1) 140 volunteers were selected, and the ages and sexes of the volunteers were determined at random and met the standards of technical standards for cosmetic safety (2015). Volunteers were randomly divided into 14 groups of 10 persons each, namely application examples 1-3, 6-12 groups, application comparative examples 1-3 groups and blank groups, wherein the volunteers of the application examples and application comparative examples groups used the biomimetic repair emulsions prepared in the corresponding groups, and the blank groups used deionized water for the same tests.
(2) The bionic hair care emulsion with the repairing efficacy is used by each group of volunteers for 1 time every 2 days, the dosage is the normal dosage of the hair care emulsion used by the volunteers at ordinary times, the volunteers score the scalp itching and dandruff degrees before the test and after the test on the 15 th day, the highest score is 10, the lowest score is 1, and the higher score is indicative of the lower degree of the itching and dandruff. The score of each volunteer was counted and the improvement rate of scalp itch and dandruff problems, scalp itch or dandruff improvement rate = (day 15-average scalp itch or dandruff score before test)/average scalp itch or dandruff score before test × 100%, and the results are shown in table 6.
(3) Scalp moisture test was carried out before and 15 days after the test using a skin moisture tester Corneometer CM825 from CK, germany, and 3 positions on the back side of the head were selected for the test, each test area was 5 cm. Times.5 cm, and the larger the test result, the higher the moisture content of the skin. The scalp moisture test results of each volunteer were counted, and the moisturizing difference rate, the moisturizing improvement rate = (day 15-average value of skin moisture test results before test)/average value of skin moisture test results before test × 100%, and the results are shown in table 6.
TABLE 6
As can be seen from the data in Table 6, the application examples 6-11 lack one or two of epigallocatechin gallate, centella asiatica extract and rosemary extract, and both the scalp itch improvement rate and the dandruff improvement rate are lower than those of the application example 1, which indicates that the combination of epigallocatechin gallate, centella asiatica extract and rosemary extract has synergistic effect, and the bionic repair hair care product with the combination of the three components has stronger dandruff-removing and itching-relieving effects.
The bionic hair care composition with the repairing effect, which is prepared by the application example 12 and the application comparative example 3, is lack of one of epigallocatechin gallate and natural mixed tocopherol respectively, and the scalp itching improvement rate and the dandruff improvement rate are lower than those of the application example 1, so that the combination of the epigallocatechin gallate and the natural mixed tocopherol is proved to have synergistic effect in the aspect of antioxidation effect, and further synergistic effect in the aspect of itching relieving and dandruff removing, and the hair care product containing the combination of the epigallocatechin gallate and the natural mixed tocopherol has stronger itching relieving and dandruff removing effects.
The bionic hair care composition with the repairing effect, which is applied to the comparative examples 1-2, is lack of one of ceramide-3 and phytosterol oleate, the improvement rate of scalp itching, the improvement rate of dandruff and the improvement rate of moisture retention are lower than those of the application example 1, and the fact that the ceramide-3 and the phytosterol oleate are matched for use shows that the bionic hair care composition has a synergistic effect on moisture retention, and the improvement of the moisture retention effect further promotes the enhancement of the effects of relieving itching and removing dandruff.
Test example 4
Evaluation of hair restoration effect of bionic hair care emulsion with restoration effect
Evaluating the hair quality repairing effect through a dynamic hair bundle combing test, wherein the specific evaluation method comprises the following steps: (1) Uniformly coating dry hair strands with the bionic hair care emulsion with the repairing effect in the application example or the application comparative example, not coating a hair care product in a blank group, washing with water after 10min, and drying; (2) The hair dressing effect of the examples of application and comparative examples of application of the present invention was evaluated using the results of the hair softness Tester SK-3A (Combing Tester SK-3A, techno Hashimoto Co., ltd.), and the lower the value, the better the Combing property, and the Combing property difference = the numerical value of each application example or comparative application example/numerical value of application example 1. Times.100%.
TABLE 7
Group of | Carding property difference ratio (%) |
Application example 1 | 100.0 |
Application example 2 | 108.6 |
Application example 3 | 105.7 |
Application example 4 | 126.0 |
Application example 5 | 145.7 |
Comparative application example 1 | 172.2 |
Comparative application example 2 | 139.0 |
As can be seen from the data in table 7, the raw materials for preparing the biomimetic hair care compositions with repairing effect of application examples 4-5 are respectively lack of one of the amino acid component and the hydrolyzed keratin component, the carding performance difference rate is higher than that of application example 1, the higher the value is, the poorer the combing property is, the more serious the hair quality damage is, the amino acid component and the hydrolyzed keratin component are used in combination, the synergy is realized, and the hair quality repairing effect is stronger;
the bionic hair care composition with the repairing effect, which is applied to the comparative examples 1-2, is lack of one of the ceramide-3 and the phytosterol oleate, the combing performance difference rate value of the comparative examples 1-2 is higher than that of the application example 1, the synergistic effect of the ceramide-3 and the phytosterol oleate on the aspect of repairing hair quality is shown, and the hair care product containing the combination of the ceramide-3 and the phytosterol oleate not only has a better scalp moisturizing effect, but also has a stronger hair quality repairing effect.
Test example 5
And (3) carrying out safety evaluation on the bionic hair care emulsion with the repairing effect prepared by the application example. The specific evaluation method comprises the following steps: the test was performed according to the human skin patch test method in the seventh chapter of human safety test methods in the cosmetic safety technical Specification 2015 edition. (1) Female volunteers required for 18-60 years old composite experiments were selected, with exclusion criteria: (a) Those who use antihistamines for nearly one week or immunosuppressants for nearly one month; (b) The tested part should be tested within two monthsThose with any anti-inflammatory drug; (c) a subject who has a clinical non-cure for an inflammatory skin disease; (d) insulin-dependent diabetic patients; (e) Patients suffering from asthma or other chronic respiratory diseases undergoing therapy; (f) subjects receiving anti-cancer chemotherapy within approximately 6 months; (g) patients with immunodeficiency or autoimmune disease; (h) lactating or pregnant women; (i) Bilateral mastectomy and bilateral underarm lymph node resection; (n) determining whether the skin part to be tested has affected the test result due to scar, pigment, atrophy, port wine stain or other flaws; (o) participation in other clinical trial investigators; (p) those with a high predisposition; (q) non-volunteer participants or those who are unable to complete the prescribed content on trial. (2) Each application example or application comparative example corresponds to one group, and each group contains 10 volunteers; the selected area is not more than 50mm 2 And qualified spot test equipment with the depth of about 1 mm. The formulations prepared in the application examples or application comparative examples were placed in a plaque tester cell in an amount of about 0.025g. The control wells were blanked without any material. The spot test device with the test substance is applied to the back or the forearm curve of the subject with hypoallergenic tape, and is applied to the skin uniformly by pressing with the palm for 24h. (3) Skin reactions were observed at 30min (after disappearance of the indentation), 24h and 48h after removal of the test article plaque test apparatus, respectively, according to the criteria of table 1. And evaluated according to the criteria of table 8.
TABLE 8
The result shows that the bionic hair care emulsion with the repairing efficacy is safe, free of stimulation and high in use value.
The applicant states that the preparation process of the present invention is illustrated by the above examples, but the present invention is not limited to the above examples, i.e. it does not mean that the present invention must rely on the above examples to be implemented. It should be understood by those skilled in the art that any modifications of the present invention, equivalent substitutions of the raw materials of the product of the present invention, and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (10)
1. A biomimetic hair care composition with restorative efficacy, wherein the biomimetic hair care composition with restorative efficacy comprises biomimetic lipids including squalane, jojoba oil, butylene glycol dicaprylate/dicaprate, phytosterol oleate, tocopherol, and ceramide.
2. The bionic hair care composition with the repairing effect according to claim 1, wherein the bionic lipid comprises 5-40 parts of squalane, 5-40 parts of jojoba oil, 5-30 parts of butanediol dicaprylate/dicaprate, 1-10 parts of phytosterol oleate, 1-20 parts of tocopherol and 0.1-3 parts of ceramide by mass.
3. The biomimetic hair care composition with restoration efficacy according to claim 1 or 2, wherein the biomimetic hair care composition with restoration efficacy further comprises a biomimetic hair ingredient;
preferably, the biomimetic hair component comprises an amino acid component and/or hydrolysed keratin;
preferably, the biomimetic hair ingredient comprises an amino acid ingredient and a hydrolysed keratin;
preferably, the amino acid component comprises any one of glycine, alanine, leucine, isoleucine, valine, cystine, cysteine, methionine, threonine, serine, phenylalanine, tyrosine, tryptophan, proline, hydroxyproline, glutamic acid, or aspartic acid, or a combination of at least two thereof.
4. The bionic hair care composition with the repairing efficacy according to claim 3, wherein the bionic hair component comprises 0.1-3 parts of amino acid component and/or 0.1-3 parts of hydrolyzed keratin in parts by mass.
5. The biomimetic hair care composition with restoration efficacy according to any of claims 1-4, wherein the biomimetic hair care composition with restoration efficacy further comprises an efficacy assisting ingredient;
preferably, the efficacy auxiliary ingredient comprises any one or a combination of at least two of epigallocatechin gallate, centella asiatica extract or rosemary extract;
preferably, the efficacy adjunct ingredient comprises a combination of epigallocatechin gallate, centella asiatica extract and rosemary extract;
preferably, the efficacy auxiliary component comprises any one or the combination of at least two of 0.01 to 0.2 portion of epigallocatechin gallate, 0.1 to 3 portions of centella asiatica extract or 0.1 to 3 portions of rosemary extract in portion by mass.
6. A bionic hair care preparation with a repairing function, which is characterized in that a raw material for preparing the bionic hair care preparation with the repairing function comprises the bionic hair care composition with the repairing function of any one of claims 1-5.
7. The biomimetic hair care formulation with restoration efficacy according to claim 6, wherein the formulation is in a form of essence, lotion, cream, gel, spray, or liquid dressing.
8. A preparation method of a bionic hair care emulsion with a repairing effect is characterized by comprising the following steps:
(1) Preparing an oil phase, wherein the oil phase is prepared by using raw materials comprising the hydrophobic ingredient, the emulsifier and the emulsification aid in the bionic hair care composition with the repairing effect, wherein the raw materials comprise any one of the hydrophobic ingredient, the emulsifier and the emulsification aid in the bionic hair care composition with the repairing effect; preparing an aqueous phase;
(2) Mixing the oil phase and the water phase, homogenizing and emulsifying, and adding the rest ingredients of the bionic hair care composition with repairing effect of any one of claims 1-5 to obtain the bionic hair care emulsion with repairing effect.
9. The method of preparing a biomimetic hair care emulsion with restoration efficacy according to claim 8, wherein the emulsifier in step (1) comprises any one of or a combination of at least two of cetostearyl alcohol, glyceryl monostearate, self-emulsifying glyceryl monostearate, peregal O-25, cetearyl alcohol PEG-20, ceteareth-21, or vegetable alkyl glycoside;
preferably, the emulsification aid in step (1) comprises any one of or a combination of at least two of an osmotic agent, a pH adjusting agent or a thickening agent;
preferably, the osmotic agent comprises any one of bisabolol, dimethyl isosorbide or inositol or a combination of at least two of the same;
preferably, the raw material for preparing the water phase in the step (1) comprises water;
preferably, the raw materials for preparing the water phase in the step (1) further comprise a film forming agent and/or an antistatic agent;
preferably, the film former comprises any one of or a combination of at least two of hydroxyethyl cellulose, polyvinyl acetate, acrylate/octylamine acrylate copolymer, cationic guar gum, cationic cellulose, or polyvinyl alcohol;
preferably, the antistatic agent comprises any one of or a combination of at least two of behenyltrimethylammonium chloride, octadecyltrimethylammonium chloride, dialkyl dimethyl ammonium chloride, trialkyl methyl ammonium chloride or diquaternary ammonium salt;
preferably, the homogenizing and emulsifying time of the step (2) is 5-20min, and the temperature is 30-90 ℃.
10. Use of the biomimetic hair care composition with restoration efficacy according to any of claims 1-5, the biomimetic hair care formulation with restoration efficacy according to claim 6 or 7, or the biomimetic hair care emulsion with restoration efficacy according to claim 8 or 9 for preparing a hair care product.
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