CN113786361B

CN113786361B - Eye cream composition with pouch removing effect and preparation method thereof

Info

Publication number: CN113786361B
Application number: CN202111126730.2A
Authority: CN
Inventors: 杨帆; 周紫燕; 祝希宇; 郭苗; 周正; 郭阳
Original assignee: Hubei Maishite Biotechnology Co Ltd
Current assignee: Hubei Maishite Biotechnology Co Ltd
Priority date: 2021-09-26
Filing date: 2021-09-26
Publication date: 2024-01-26
Anticipated expiration: 2041-09-26
Also published as: CN113786361A

Abstract

The invention discloses an eye cream composition with an eye pouch removing effect and a preparation method thereof. The eye cream composition with the eye pouch removing effect comprises the following raw material components: 1.0 to 35.0 percent of eye pouch removing functional components, 5.0 to 40.0 percent of emollient, 0.5 to 30.0 percent of emulsifier, 0.5 to 20.0 percent of filler, 0.1 to 10.0 percent of thickener, 0.3 to 5.0 percent of preservative, 0.01 to 1.0 percent of daily essence and the balance of deionized water. The eye pouch removing functional component consists of a kappaphycus alvarezii extract, tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, dipeptide diamino Ding Xianbian-yl amide diacetate and acetyl tetrapeptide-5. The pouch-dispelling functional component starts from the factors of eye skin relaxation and edema of the pouch, and can effectively alleviate the visible problem of eye pouch protrusion, so as to bring more attractive appearance.

Description

Eye cream composition with pouch removing effect and preparation method thereof

Technical Field

The invention relates to a cosmetic composition and a preparation method thereof, belongs to the technical field of daily chemicals, and in particular relates to an eye pouch removing eye cream composition containing various pouch removing effective components and a preparation method thereof.

Background

The eye bags are a skin problem that severely affects the aesthetic appearance of the face and are also a sign of aging. The occurrence of the pouch has two main factors: on the one hand, the skin of the eyes loses elasticity with the increase of age, and the muscles of the eyes relax, so that wrinkles are formed on the faces of the eyes, and the fat of the pad in the orbit is transferred out of the cavities of the eyes and gathered on the faces of the eyes to form eye bags. Yet another important reason is that impaired lymphatic circulation and increased capillary permeability lead to oedema and thus to the formation of bags. In life, the habit of work and rest is irregular, and the people stay up frequently, so that sleep is insufficient, and long-term fatigue causes unsmooth microcirculation of eyes and generation of eye bags. In addition, lack of water in the eye skin is also greatly related to the appearance of loose bags. Pouch is a facial problem that cosmetic technology is difficult to cover, severely affecting an individual's mental appearance.

However, the pouch-removing skin care products in the current market often have the defects of unobvious pouch-removing effect, long effective period, high sensitization and the like. In the current research, although some components are applied to cosmetics singly or in pairs, the components with the effect of eliminating the eye bags are not applied to eye cream in a combined mode, the effect of eliminating the eye bags is achieved in a synergistic mode, and meanwhile the effects of fading the dark circles of the eyes and the like are achieved.

Accordingly, there is an increasing need for non-invasive, effective and risk-free cosmetic formulations that can reduce and minimize the occurrence of ocular skin imperfections, thereby providing a perpetual youthful and revitalizing appearance. How to provide an eye cream skin care product with better eye bag removing performance is a technical problem which needs to be solved by the current technicians in the field.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide an eye pouch-removing eye cream composition which contains various effective components and can synergistically increase the pouch-removing effect.

The invention also aims to provide a preparation method of the eye cream composition with the eye bag removing effect.

The technical scheme adopted by the invention is as follows.

An eye cream composition with the effect of eliminating eye bags comprises the following raw material components by weight:

1.0-35.0% of an eye pouch removal active ingredient, the eye pouch removal active ingredient comprising: 0.1-30% of Kappaphycus alvarezii extract, 0.1-30% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 0.1-30% of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.1-30% of acetyl tetrapeptide;

5.0-40.0% emollient;

0.5-30.0% of an emulsifier;

0.5-20.0% filler;

0.1-10.0% of a thickener;

0.3-5.0% preservative;

0.01-1.0% of daily essence;

and the balance of deionized water.

Furthermore, the eye cream composition with the eye pouch removing effect comprises the following components in terms of the total weight of the composition:

1.0-25.0% of eye pouch removing functional components, which comprises: 0.5-20% of Kappaphycus alvarezii extract, 0.5-20% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 5-20% of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.5-20% of acetyl tetrapeptide;

further, the eye pouch removing functional component comprises the following raw material components:

0.5-10% of Kappaphycus alvarezii extract, 0.5-10% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 0.5-10% of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.5-10% of acetyl tetrapeptide.

0.5-5% of Kappaphycus alvarezii extract, 0.5-5% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 0.5-5% of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.5-5% of acetyl tetrapeptide.

0.5-3% of Kappaphycus alvarezii extract, 0.5-3% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 0.5-3% of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.5-3% of acetyl tetrapeptide.

Further, the eye cream composition with the eye pouch removing effect comprises the following components in terms of the total weight of the composition:

2.5-9.0% of eye pouch removing functional components, which comprise: 1 to 5 percent of kappaphycus alvarezii extract, 0.5 to 1.0 percent of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 0.5 to 1.0 percent of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.5 to 1.5 percent of acetyl tetrapeptide;

further, the emollient is selected from at least one of caprylic capric triglyceride, squalane, avocado oil, shea butter, jojoba oil, glycerin, butylene glycol, hexylene glycol, 1, 2-pentanediol, panthenol, sodium hyaluronate, tocopherol, tocopheryl acetate, polydimethylsiloxane, dimethiconol, PEG-11 methyl ether dimethicone, C12-16 alcohol, phytosterol/octyldodecyl lauroyl glutamate, hydrogenated polyisobutylene, rapeseed oil, polydecene, soybean oil, olive oil, isododecane, isohexadecane, stearyl alcohol, behenyl alcohol. The content is selected from the range of 5-30%, preferably 8-15%.

The emulsifier is selected from at least one of olive oil, palmitic acid, cholesterol, PEG-7 esters, PEG-8 caprylic/capric glycerides, sorbitan olive oleate, polysorbate-20, octyldodecanol, laureth-23, stearic acid, hydrogenated lecithin, oleyl erucate, steareth-21, palmitols and mixtures of PEG-75 stearate and glyceryl stearate and steareth-20, polysorbate-80, soybean lecithin PC60, mixtures of glyceryl stearate and PEG-75 stearate, poloxamer 407, PEG-30 dimerized hydroxystearate, cetostearyl ether-25. The content is selected from the range of 0.5-15%, preferably 1-10%.

The filler is at least one selected from titanium dioxide, mica, boron nitride, polymethylsilsesquioxane, diatomite, kaolin, cellulose acetate, aluminum starch octyl succinate, talcum powder, zinc sulfate and volcanic ash. The content is selected from the range of 0.2-20%, preferably from the range of 0.5-15%, most preferably from the range of 1% -4%.

The thickener is at least one selected from hydroxyethyl cellulose, 1, 3-propylene glycol, xanthan gum, carbomer, acrylic acid (ester) copolymer, polymer EMT-10, polyacrylate crosslinked polymer-6, sodium acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (ester) C10-30 alkanol acrylate crosslinked polymer, acrylamide/VP copolymer, polyethylene and gum arabic. The content is in the range of 0.5-8%, preferably 1-5%.

In addition, the invention also discloses a preparation method of the eye cream composition with the eye pouch removing effect, which comprises the following process steps:

1) Wetting and dispersing the thickener in water completely to obtain a mixed solution;

2) Adding the eye pouch removing functional components, the emollient, the filler and the preservative into the mixed solution in the step 1), heating to 65 ℃, homogenizing for 3 minutes at 3000r/min to enable the mixed solution composition to be completely dispersed;

3) Adding an emulsifying agent and daily essence into the mixed liquid composition formed in the step 2), homogenizing for 3 minutes at 3000r/min to completely emulsify, and heating to 65 ℃ to obtain the eye cream composition with the eye bag removing effect.

In particular, the eye cream composition of the present invention having an eye-bag removing effect has a pH in the range of 4 to 10, preferably a pH in the range of 5 to 8, and most preferably a pH in the range of 5 to 7.

Specifically, the eye cream composition with the eye bag removing effect can be in a solvent dispersion or suspension mode, can be in the form of emulsified particles or can be in the form of polymer packages.

In particular, the cosmetics of the eye and pouch removing efficacy composition of the invention are skin care products, in particular, emulsions, essences, creams, eye creams, body milks, gels, sun protection milks.

By means of the technical scheme, the invention has the following advantages and beneficial technical effects:

1) The invention contains a plurality of active ingredients with detumescence and skin relaxation improving effects, such as the kappaphycus alvarezii extract, tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, dipeptide diamino Ding Xianbian amino diacetic acid, acetyl tetrapeptide-5 and the like, and can play a role in reducing the eye bags for the skin of eyes.

2) The eye pouch removing functional component composition is selected from the group consisting of a Kappaphycus alvarezii extract, tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, dipeptide diamino Ding Xianbian base amide diacetate and acetyl tetrapeptide-5, and cosmetics can pass the preferred combination and the efficacy test, find that the most preferred composition proportion is effective in removing the pouch.

3) Compared with most of cosmetics sold in the market at present, the eye cream composition for removing the eye bags provided by the embodiment of the invention has obvious synergistic effect, is suitable for more crowds with different skin types, and has wide application range, and after being used by a user, the eye bags are obviously reduced, and the skin elasticity is obviously increased. The components of the invention are mutually cooperated to achieve the safe and effective detumescence and eye bag removal effects.

4) The novel eye pouch-removing eye cream composition can relieve edema of lower eyelid, and provides many ideal benefits for eye care so as to bring younger face.

Drawings

FIG. 1 is a schematic view showing the reinforcement of collagen fibers by the composition for eliminating the pouch;

FIG. 2 is a graph showing the results of enhancement of proteoglycan expression by the pouch-dispelling efficacy composition;

FIG. 3 is a graph showing the comparison of the anterior and posterior pouch volume values using the eye cream composition of example 1;

FIG. 4 shows the relative change in the volume of the anterior and posterior eye bags using the eye cream composition of example 1;

fig. 5 shows the rate of change of the volume of the anterior and posterior eye bags using the eye cream composition of example 1.

Detailed Description

The invention discloses an eye cream composition with an eye pouch removing effect and a preparation method thereof. The eye pouch removing efficacy cream composition comprises the following raw material components:

1.0 to 35.0 percent of eye pouch removing functional components, 5.0 to 40.0 percent of emollient, 0.5 to 30.0 percent of emulsifier, 0.5 to 20.0 percent of filler, 0.1 to 10.0 percent of thickener, 0.3 to 5.0 percent of preservative, 0.01 to 1.0 percent of daily essence and the balance of deionized water.

The eye pouch removing functional component is prepared by mixing a kappaphycus alvarezii extract, tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, dipeptide diamino Ding Xianbian-yl amide diacetate and acetyl tetrapeptide-5.

Capparis longus is a red algae growing in tropical or subtropical regions, such as Hainan, xisha islands, taiwan, etc. in China. The extract contains carrageenan as main component, and contains rich amino acids (such as glycine, leucine, glutamic acid, etc.) and small amount of polyphenols. Therefore, the Kappaphycus alvarezii extract has good hygroscopicity, improves the structural integrity of horny layer and the biosynthesis function of epidermis of dry skin, provides sufficient moisture and nutrient mineral substances for the skin, helps to maintain the moisture level of the skin throughout the day, regulates the dynamic balance of the skin, and improves the phenomenon of water deficiency and relaxation of the skin.

The preparation method of the kappaphycus alvarezii extract comprises the following steps:

1) Selecting algae: selecting fresh Kappaphycus alvarezii, removing impurities such as grass sticks and sediment attached to the leaves of the Kappaphycus alvarezii, soaking in 75% ethanol solution for 15-30 min, and air-drying for later use;

2) Drying and powdering: drying the pretreated Kappaphycus alvarezii in the step 1) in an environment of 50-80 ℃ for 36-48 h until the moisture content in algae leaves is reduced to below 8%, taking out the dried Kappaphycus alvarezii, pulverizing into powder, and sieving with a 80-200-mesh sieve to obtain algae powder;

3) Foaming and ultrasonic treatment: mixing the algae powder and water in the step 2) according to the mass ratio of 1:20, foaming for 8 hours to obtain a mixed solution, placing the mixed solution into an ultrasonic cell crusher, and performing ultrasonic treatment for 6-8 hours under the condition of 200-500W of power to obtain a Kappaphycus alvarezii ultrasonic solution;

4) And (3) enzymolysis and fermentation: adding citric acid into the alga ultrasonic solution in the step 3), adjusting the pH value of the solution to 4.0-6.0, adding 6X 104-8X 104U/L pectase and 0.1X 104-1X 104U/L cellulase into the alga ultrasonic solution, and carrying out enzymolysis for 3-5 hours at 40-60 ℃; heating the hydrolyzed alga ultrasonic solution to boiling, inactivating enzyme for 5-20 minutes, and cooling to room temperature to obtain alga enzymolysis solution;

5) And (3) filtering, decompressing, distilling and collecting: adding 90% ethanol into the algae enzymolysis liquid in the step 4), extracting for 12 hours at 30 ℃, filtering, taking filtrate, distilling under reduced pressure, and removing ethanol in the solution to obtain the Kappaphycus alvarezii extract.

The tetradecylamino Ding Xianxie amino butyric urea trifluoroacetate can promote the generation of basal membrane glycan and core protein glycan of dermis, endogenously promote the generation of epidermis and dermis hyaluronic acid, help skin absorb moisture from the body and the skin surface, enhance the long-time water retention capacity of the skin, improve the quality of collagen fiber after long-term use, and have the functions of remodelling and tightening the skin. Can act on dermis layer, promote synthesis of natural skin hyaluronic acid, and increase synthesis of collagen fiber, thereby improving skin relaxation phenomenon.

Dipeptide diamino Ding Xianbian-yl amid diacetate is a small peptide that mimics the activity of the snake venom Waglein I, acts on postsynaptic membranes, and is a reversible antagonist of the muscle nicotinic acetylcholine receptor (nmAChR). Dipeptide diamino Ding Xianbian-yl amidediacetate binds to the epsilon subunit of nmAChR thereby blocking the binding of acetylcholine to the receptor, eventually resulting in receptor blocking, inability of sodium ions to uptake, inability to depolarize, blockade of neuronal excitation transmission, and hence relaxation of the muscle. Therefore, the squeezing of the muscle to the skin can be reduced, and the state of loose skin around eyes can be relieved.

There are two routes to eliminating the pouch for acetyl tetrapeptide-5, the first of which is to inhibit glycosylation of the skin around the eye. Glycosylation often results in abnormal, chaotic crosslinking of collagen fibers. Instead of allowing all collagen fibers to work together in a uniform, organized manner, glycation results in a decrease in skin elasticity. Acetyl tetrapeptide-5 can increase vascular permeability and effectively eliminate edema. Acetyl tetrapeptide-5 acts against this situation by binding to a protein involved in glycosylation, preventing it from binding to the next substance needed to continue glycosylation, thus stopping glycation on its orbit. The second approach is to reduce the amount of accumulated fluid in the region by changing the permeability of the blood vessels in the region, by reducing the permeability of the blood vessels in the region.

The eye pouch removing effect composition consists of a Kappaphycus alvarezii extract, tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, dipeptide diamino Ding Xianbian amino diacetic acid salt and acetyl tetrapeptide-5. The Kappaphycus alvarezii extract in the composition provides sufficient water and nutrient minerals for skin, maintains skin elasticity, ensures skin smoothness and elasticity, retains moisture and water, nourishes skin, and prevents skin dryness and laxity. The acetyl tetrapeptide-5 can be used for diminishing inflammation and eliminating eye edema by changing vascular permeability, and then the tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, the dipeptide diamino Ding Xianbian amino diacetic acid and the acetyl tetrapeptide-5 can be used for playing roles in tightening skin and improving skin elasticity, and can be used for increasing the effect of eliminating eye bags by synergistic effect, and meanwhile, the eye fine wrinkles and melanin deposition can be reduced.

The effective components for eliminating the pouch can effectively alleviate the visible problem of protruding the pouch of the eye from the factors of eye skin relaxation and edema which induce the pouch of the eye, so as to bring more attractive appearance.

The invention is illustrated by the following examples which are given for further illustration of the invention and are not intended to limit the scope of the invention. Some insubstantial modifications and adaptations of the invention by others are within the scope of the invention.

The following percentages (%) are mass percentages unless otherwise indicated. All raw material components of the invention are commercial products.

Examples 1 to 4

An eye cream composition with eye pouch removing effect is prepared into eye pouch removing eye cream, and the contents of the raw material components are shown in the following table 1.

TABLE 1 raw material composition ratio (unit: mass%) of examples 1-4

Comparative examples 1 to 8

An eye cream composition with eye pouch removing effect is prepared into eye pouch removing eye cream, and the content of the raw materials in the composition ratio of comparative examples 1-8 is shown in the following table 2.

Table 2 proportion of raw material components (unit: mass%) of comparative examples 1 to 8

The preparation method of the eye pouch removing effect eye cream composition of the embodiment and the comparative example comprises the following process steps:

2) Adding the eye pouch removing functional components, the emollient, the filler and the preservative into the mixed solution in the step 1), heating to 65 ℃, homogenizing for 3 minutes at 3000r/min to enable the components to be completely dispersed;

3) Adding the emulsifying agent and the daily essence into the step 2), homogenizing for 3 minutes at 3000r/min to completely emulsify, and heating to 65 ℃ to obtain the eye cream composition with the eye pouch removing effect.

The pH of examples 1-4 was 6.0-7.0, respectively.

Effect verification test example

Test example 1 of the effect of enhancing proteoglycan expression by the efficacy Material

1) Test sample: the composition for eliminating the pouch in the eyes of the embodiment 1 comprises a Kappaphycus alvarezii extract, tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, dipeptide diamino Ding Xianbian-yl amide diacetate and acetyl tetrapeptide-5; two-by-two effective components; the specific composition is shown in Table 3.

TABLE 3 efficacy raw materials enhanced proteoglycan expression Effect test component ratio (Unit: concentration. Mu.M)

2) The testing method comprises the following steps: testing was performed on Normal Human Fibroblasts (NHF). Cells were cultured for three days in the absence of calf serum (FCS) and expression of decorin and zymosan was measured.

3) Test results:

the mechanism of strengthening collagen fibers by the composition for eliminating the pouch is shown in figure 1, and decorin and basilemma are two important proteoglycans in the dermis layer. Their protein portions will bind to the collagen fibers, while the glycosaminoglycan portions will separate and fill the spaces between the collagen fibers. Before the functional composition is added, collagen fiber pores of dermis layers of the skin are uneven, and the expression quantity of decorin and basilemma glycan with filling function is limited; after the composition with the eye bag dispelling efficacy is added, the levels of the decorin and the basilemma glycan are obviously improved, the connection of collagen fibers is enhanced, fine lines caused by fiber breakage are reduced, meanwhile, the glycosaminoglycan fills gaps among the collagen fibers, the pore diameters of the fibers are recovered to be normal, the collagen fibers are healthier, and the skin is recovered to be in a young state.

The experimental results are shown in fig. 2, and the effect of promoting the expression of two kinds of proteoglycan by the efficacy composition of the synergistic example 1 is greater than that of the efficacy composition of the synergistic example. Specifically, the efficacy composition increases the expression level of the basal lamina polysaccharide by 70%, increases the expression of the core protein polysaccharide by 77%, and the expression level of the two kinds of protein polysaccharide is higher than that of the efficacy raw materials combined two by two. Through the synergistic effect of the functional compositions, the expression of two kinds of protein sugar is obviously increased, so that collagen fibers can be finer, and the fiber quality and strength are better.

Test example 2 of the effect of eliminating the pouch

1) The tester: 32 healthy people (20-45 years old), women: the face has no obvious redness, skin damage, scars and the like;

2) Test sample and site: example 1; periocular region;

3) Test instrument: primos is used for facial image acquisition and wrinkle and pouch analysis;

4) The test indexes are as follows: pouch volume; wherein, the rate of change= (post-use measurement-pre-use measurement)/(pre-use measurement x 100%;

the test results are shown in the following FIGS. 3-5 and tables 4-6:

table 4 shows the comparison of the eye pouch volume values before and after use of the eye cream composition of example 1

	Before use	After 7 days of use	After 14 days of use	After 28 days of use	After 42 days of use
						Example 1	73.74	66.13	64.3	67.97	61.32
Blank examples	74.89	81.15	73.16	75.89	75.25

Compared with the prior use: 7 days after the sample was used, the sample area pouch volume was significantly reduced by 7.61; the sample area had a significant decrease in the pouch volume of 9.44 after 14 days of sample use; after 28 days of using the sample, the pouch volume in the sample area was not significantly reduced by 5.77; after 42 days of sample use, the sample area pouch volume was significantly reduced by 12.42.

Table 5 change value of the eye cream composition of example 1 compared to the prior use

	After 7 days of use	After 14 days of use	After 28 days of use	After 42 days of use
					Example 1	-7.61	-9.44	-5.77	-12.42
Blank examples	6.26	-1.73	1.00	0.36

TABLE 6 rate of change before use of the eye cream composition of example 1

	After 7 days of use	After 14 days of use	After 28 days of use	After 42 days of use
					Example 1	-10.32％	-12.80％	-7.83％	-16.85％
Blank examples	8.36％	-2.31％	1.34％	0.48％

Meanwhile, the calculation result of the change rate shows that: after 7 days of using the sample, the volume of the eye bag of the sample area is obviously reduced by 10.32%, and the volume of the eye bag of the control area is not obviously increased by 8.36%; after 14 days of using the sample, the volume of the eye bag of the sample area is obviously reduced by 12.80%, and the volume of the eye bag of the control area is not obviously reduced by 2.31%; after 28 days of using the sample, the volume of the eye bag of the sample area is obviously reduced by 7.83%, and the volume of the eye bag of the control area is not obviously increased by 1.34%; after 42 days of sample application, the sample area pouch volume was significantly reduced by 16.85% and the control area pouch volume was not significantly increased by 0.48%.

As can be seen from the data in fig. 3-5 and tables 4-6, the effect of the invention for reducing the volume of the pouch in example 1 is obvious, and the effective components for eliminating the pouch used in the invention have good effect.

Ophthalmic doctor clinical evaluation trial 3

1. The tester: 30 healthy people (20-45 years old), female: the face has no obvious redness, skin damage, scars and the like;

2. test part: periocular region;

3. the evaluation criteria are shown in Table 7 below:

TABLE 7 ophthalmic clinical assessment scoring criteria table

4. The test results are shown in table 8 below:

TABLE 8 ophthalmic clinical evaluation results

During the use of the samples, 0 subjects developed adverse reactions at the eyelid, eyelid margin and eyelash, eyelid conjunctiva, cornea, anterior chamber, light reflex, etc.

Safety verification test example 4

1) Number of test persons: 30 healthy persons (20-45 years old), test case-like formula.

2) Test part: forearm curved side;

3) The testing method comprises the following steps: a suitable patch tester with the area not exceeding 50mm < 2 > and the depth of about 1mm is selected, and about 0.020-0.025 mL (g) of a test object is added into the patch tester by a closed patch test method. The patch tester was applied to the forearm of the subject, the test substance was removed after 24 hours, and skin reactions were observed at 0.5, 24, and 48 hours after the removal, and the results were recorded according to the skin reaction classification standard in cosmetic safety technical Specification 2015.

4) The evaluation criteria are shown in Table 9 below:

TABLE 9 skin reaction grading criteria

The results show that: the results of the human skin patch test showed that the score levels of 3 observation time points 0.5h, 24h and 48h after patch removal were all 0 points for 30 subjects. According to the specification of cosmetic safety technology (2015 edition), the test object does not cause adverse skin reaction to the subjects in the batch.

Synergistic test example 5

1) The tester: 90 healthy persons (20-45 years old), 9 groups of 10 persons each, women: the face has no obvious redness, skin damage, scars and the like; example 1, comparative examples 1-8 were used, respectively;

2) Test part: periocular region;

4) The test indexes are as follows: pouch volume.

The test results are shown in tables 10-11 below:

table 10 comparison of pouch volume values before and after use of the eye cream compositions of example 1 and comparative examples 1-8

Table 11 change in pouch volume values before and after use of the eye cream compositions of example 1 and comparative examples 1 to 8

	After 7 days of use	After 14 days of use	After 28 days of use	After 42 days of use
					Example 1	-7.06	-8.96	-10.07	-12.54
Comparative example 1	-4.53	-4.81	-5.06	-5.37
					Comparative example 2	-4.28	-4.52	-4.84	-5.03
Comparative example 3	-4.11	-4.32	-4.79	-4.91
					Comparative example 4	-4.47	-4.76	-4.93	-5.12
Comparative example 5	-4.02	-4.29	-4.67	-4.85
					Comparative example 6	-3.59	-3.78	-4.05	-4.11
Comparative example 7	-3.37	-3.64	-3.96	-4.05
					Comparative example 8	-3.86	-3.97	-4.16	-4.23

The pouch-removing effect test was performed on example 1 and comparative examples 1 to 8, and the test results are shown in tables 10 to 11.

As can be seen from table 10, after 7 days of use, the pouch volume sizes were ordered as: comparative example 7 > 6 > 8 > 5 > 3 > 2 > 4 > 1 > example 1. After 14 days of use, the pouch volume size was ordered as: comparative example 1 > 2 > 4 > 3 > example 1; after 28 days of use, the pouch volume size was ordered as: comparative example 7 > 6 > 8 > 5 > 3 > 2 > 4 > 1 > example 1. After 42 days of use, the pouch volume size was ordered as: comparative example 7 > 6 > 8 > 5 > 3 > 2 > 4 > 1 > example 1.

As can be seen from table 11, after 7 days of use, the pouch volume reduction values were ranked as: example 1 > comparative example 1 > 4 > 2 > 3 > 5 > 8 > 6 > 7. After 14 days of use, the pouch volume reduction values were ranked as: example 1 > comparative example 1 > 4 > 2 > 3 > 5 > 8 > 6 > 7. After 28 days of use, the pouch volume reduction values were ranked as: example 1 > comparative example 1 > 4 > 2 > 3 > 5 > 8 > 6 > 7. The pouch volume reduction values are ordered as: example 1 > comparative example 1 > 4 > 2 > 3 > 5 > 8 > 6 > 7.

The results of each period of use show that the volume reduction value of the eye bags in the embodiment 1 is obviously larger than that of the control group, and the four functional components of the invention have synergistic eye bag removal effect.

The eye and eye bag removing effect composition consisting of the Kappaphycus alvarezii extract, the tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate dipeptide diamino Ding Xianbian-yl amide diacetate and the acetyl tetrapeptide-5 can synergistically play the effect of removing the eye bag and mutually cooperate. Firstly, the kappaphycus alvarezii extract can effectively supplement water and preserve moisture, relieve dry skin relaxation and inhibit melanin generation; the acetyl tetrapeptide-5 can be used for diminishing inflammation and eliminating eye edema by changing vascular permeability, and then the tetradecylamino Ding Xianxie amino butyric acid urea trifluoroacetate, the dipeptide diamino Ding Xianbian amino diacetic acid and the acetyl tetrapeptide-5 can be used for playing roles in tightening skin and improving skin elasticity, and can be used for increasing the effect of eliminating eye bags by synergistic effect, and meanwhile, the eye fine wrinkles and melanin deposition can be reduced.

In conclusion, the pouch-removing efficacy compound has obvious pouch-removing effect through the synergistic effect among the components, and is more obvious than the pouch-removing effect of the combination of two components and three components.

The foregoing description is only a preferred embodiment of the present invention and is not intended to limit the invention in any way, so any simple modification, equivalent variation and modification made to the above embodiment according to the technical matter of the present invention will still fall within the scope of the technical scheme of the present invention.

Claims

1. An eye cream composition with the effect of eliminating eye bags, which is characterized in that: based on the total weight of the composition, the composition consists of the following raw materials:

1.0-25.0% of eye pouch removal efficacy components, wherein the eye pouch removal efficacy components comprise: 0.5-20% of Kappaphycus alvarezii extract, 0.5-20% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 0.5-20% of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.5-20% of acetyl tetrapeptide;

5.0-40.0% emollient;

0.5-30.0% of an emulsifier;

0.5-20.0% filler;

0.1-10.0% of a thickener;

0.3-5.0% preservative;

0.01-1.0% of daily essence and the balance of deionized water.

2. An eye cream composition with pouch-removing efficacy as claimed in claim 1, wherein: based on the total weight of the composition, the composition consists of the following components:

1.0-25.0% of eye pouch removing effective components, wherein the eye pouch removing effective components comprise: 0.5-20% of Kappaphycus alvarezii extract, 0.5-20% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 0.5-20% of dipeptide diamino Ding Xianbian-yl amidodiacetate and 0.5-20% of acetyl tetrapeptide;

5.0 to 30.0 percent of emollient;

0.5-25.0% of emulsifying agent;

1-15.0% of filler;

0.5-8.0% of thickener;

0.3-1.0% of preservative;

0.01-0.05% of daily essence;

the balance of deionized water was added to 100%.

3. An eye cream composition with pouch-removing efficacy as claimed in claim 1, wherein: the eye pouch removing functional components comprise:

1-10% of kappaphycus alvarezii extract, 1-10% of tetradecylamino Ding Xianxie amino amidobutyric acid urea trifluoroacetate, 1-10% of dipeptide diamino Ding Xianbian amidodiacetic acid and 5 1-10% of acetyl tetrapeptide.

4. An eye cream composition with pouch-removing efficacy as claimed in claim 1, wherein: the eye pouch removing functional components comprise:

5. An eye cream composition with pouch-removing efficacy as claimed in claim 1, wherein: the emollient is selected from at least one of caprylic capric triglyceride, squalane, avocado oil, shea butter, jojoba oil, glycerol, butylene glycol, hexylene glycol, 1, 2-pentanediol, panthenol, sodium hyaluronate, tocopherol, tocopheryl acetate, dimethicone, dimethiconol, PEG-11 methyl ether dimethicone, C12-16 alcohol, phytosterol/octyldodecyl lauroyl glutamate, hydrogenated polyisobutene, rapeseed oil, polydecene, soybean oil, olive oil, isododecane, isohexadecane, stearyl alcohol, behenyl alcohol;

the emulsifier is at least one selected from olive oil, palmitic acid, cholesterol, PEG-7 esters, PEG-8 caprylic/capric glycerides, sorbitan olive oleate, polysorbate-20, octyldodecanol, laureth-23, stearic acid, hydrogenated lecithin, oleyl erucate, steareth-21, palmitol and PEG-75 stearate and a mixture of glyceryl stearate and steareth-20, polysorbate-80, soybean lecithin PC60, a mixture of glyceryl stearate and PEG-75 stearate, poloxamer 407, PEG-30 dimerized hydroxystearate, cetostearyl ether-25;

the filler is at least one selected from titanium dioxide, mica, boron nitride, polymethylsilsesquioxane, diatomite, kaolin, cellulose acetate, starch octyl aluminum succinate, talcum powder, zinc sulfate and volcanic ash;

the thickener is at least one selected from hydroxyethyl cellulose, 1, 3-propylene glycol, xanthan gum, carbomer, acrylic acid (ester) copolymer, polymer EMT-10, polyacrylate crosslinked polymer-6, sodium acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (ester) C10-30 alkanol acrylate crosslinked polymer, ammonium acryloyldimethyl taurate/VP copolymer, polyethylene and gum arabic.

6. A method for preparing an eye cream composition with the effect of eliminating eye bags according to any one of claims 1 to 5, which comprises the following process steps:

7. A cosmetic product characterized by: the cosmetic comprises the eye cream composition with the eye pouch removing effect prepared by the preparation method of claim 6.

8. The cosmetic product of claim 7, wherein: the cosmetic is in the form of solvent dispersion or suspension, or in the form of emulsified particles, or in the form of polymer packages.