CN109223602A - The method for customizing of eye skin care item and eye maintenance method - Google Patents

The method for customizing of eye skin care item and eye maintenance method Download PDF

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Publication number
CN109223602A
CN109223602A CN201811400907.1A CN201811400907A CN109223602A CN 109223602 A CN109223602 A CN 109223602A CN 201811400907 A CN201811400907 A CN 201811400907A CN 109223602 A CN109223602 A CN 109223602A
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parts
skin
eye
xylitol
functional component
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Inventor
王娟
孙云起
孙怀庆
裴运林
聂艳峰
刘露
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Guangdong Marubi Biological Technology Co Ltd
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Guangdong Marubi Biological Technology Co Ltd
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Priority to CN201811400907.1A priority Critical patent/CN109223602A/en
Publication of CN109223602A publication Critical patent/CN109223602A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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Abstract

The present invention provides a kind of method for customizing of eye skin care item and eye maintenance methods, are related to the technical field of skin care item.The method for customizing of the eye skin care item includes: to match functional component according to the parameter of the characterization eye problems of customized objects, and the eye skin care item comprising the functional component are then made.The present invention uses the eye part skin problem of parameter characterization customized objects, so that the eye part skin problem of customized objects more intuitively can be reacted and be measured, then corresponding functional component, the eye part skin for solving the problems, such as customized objects for being directed to the eye skin care item produced more are matched according to parameter.The inventive concept of method for customizing based on above-mentioned eye skin care item, the present invention also provides a kind of eye maintenance methods, this method includes the skin care item nursing eye circumference skin being prepared using the preparation method of above-mentioned customization eye skin care item, this method can effectively alleviate eye circumference dry skin problem, restore eye circumference elasticity of skin and reduce wrinkle and black eye.

Description

The method for customizing of eye skin care item and eye maintenance method
Technical field
The present invention relates to technical field of skin care, method for customizing and eye maintenance more particularly, to a kind of eye skin care item Method.
Background technique
Eyes are the positions for revealing the age earliest on the face, and vigorous eyes can allow whole face all to show younger. But since eye part skin is most thin one of the skin of human body, the thickness on eye part skin surface layer is only the 1/3-1/5 of face, daily Blink about 1000 times, and 14 groups of muscle of circumference of eyes are employed, cause eye circumference skin to be easier than the skin at other facial positions Existing problem.
In acidity, have prevents from being dehydrated the water adipose membrane of the sweat of sweat gland secretion and fat composition, lubricates skin in general skin The effect of injury of the external environment to skin is divided in skin, blocking part, is the natural protective film of skin.And circumference of eyes only has sebaceous glands With abnormal sweat gland, it only has independent sweat gland without the distribution of sebum, thus water adipose membrane to the protective effect of eye part skin very It is small.In addition eye part skin fat content is few, and lack flexibility fiber and collagen structure in skin corium, therefore eye part skin is easy to lose bullet Property.Therefore there is allergy compared with influencing vulnerable to external factor, or even occur shifting to an earlier date aging phenomenon.
The nerve fibre and capillary distribution density of circumference of eyes are very high, enable the circulation and lymphatic system fortune of circumference of eyes Row is slower, be easy to cause the feeling of fatigue of eye, and poor blood circulation will cause extravasated blood, causes eye dim.Experiment shows to lead to It crosses and the test of eye circumference skin is carried out to Chinese women, the hemochrome protein content of palpebra inferior is higher than cheek, skin elasticity and cheek phase Decline than.
Since eye part skin has the characteristics that above, daily life system is abnormal, in bad health and improper etc. with eye Phenomena such as will causing eye part skin dimness, accelerated ageing, eye part skin relaxation, and along with black eye, eye pouch, canthus line, The eye problems such as ocular edema, fat granule.
Further, due to extraneous factors and operating pressure and bad lives such as ultraviolet light irradiation, the radiation of long-time computer Habit causes black eye, eye pouch, crow's feet and fat granule crowd gradually to increase.These eye part skin problems are listless to people, The mental attitude of fatigue, while the more aging that seems.Show according to the study in China, there are eye circumference skin to ask by 50% or more women The worry of topic, and with age, the crowd for the eye part skins problem such as black eye, wrinkle, eye pouch occur increases, therefore consumes The effects of person gradually focuses on eye part skin nursing, seeks the beautification of cosmetics, repairs is to reach compact, fine and smooth, flexible Eye skin state.
But an outstanding problem of existing eye cream is, single formula is not appropriate for owner, because of everyone gender The climatic season of different, age difference, locating region or working environment difference, location is different, and living habit is different, this is all It may cause single eye cream to be not quite similar to the effect of eye skin.Therefore, existing single formula eye cream unsuitable people Class skin physiology nurses Dermatology and proposes otherness demand.It is a kind of to customize eye cream according to the eye problems of applicable object Method is existing market needs.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of method for customizing of eye skin care item, and this method alleviates the prior art Present in lack there is the method for targetedly customizing eye cream for personalized eye problems.
The second object of the present invention is to provide a kind of eye maintenance method, and this method includes the above-mentioned customization eye of the right to use The skin care item that the preparation method of skin care item is prepared nurse eye circumference skin.
In order to solve the above technical problems, spy of the present invention adopts the following technical scheme that
A kind of method for customizing of eye skin care item, comprising: function is matched according to the parameter of the characterization eye problems of customized objects Ingredient is imitated, the eye skin care item comprising the functional component are then made.
Preferably, the eye problems include moisture content of skin, skin pigment content, skin elasticity, dermatoglyph degree and One or more of skin smoothness.
Preferably, if moisture content of skin≤40C.U, A1 group functional component is matched；If 40C.U < moisture content of skin≤ 60C.U matches A2 group functional component；If moisture content of skin > 60C.U, A3 group functional component is matched；
Preferably, the A1 group functional component, the A2 group functional component and the A3 group functional component be independently Including one or more of ceramide, Xylitol-based glucoside, anhydro xylitol, xylitol；
Preferably, the A1 group component include: in parts by weight -5 parts of Cer NP, it is glucoside 5-6 parts Xylitol-based, 5-6 parts and xylitol 5-6 parts of anhydro xylitol；
Preferably, the A2 group component include: in parts by weight -3 parts of Cer NS, it is glucoside 3-5 parts Xylitol-based, 3-5 parts and xylitol 3-5 parts of anhydro xylitol；
Preferably, the A3 group component include: in parts by weight -2 parts of Cer EOS, it is glucoside 1-3 parts Xylitol-based, 1-3 parts and xylitol 1-3 parts of anhydro xylitol.
Preferably, with skin elasticity R2 value characterize skin elasticity, if value≤0.5 skin elasticity R2, matching B1 group effect at Point；If 0.5 value≤0.7 < skin elasticity R2, B2 group functional component is matched；If skin elasticity R2 value > 0.7, B3 group effect is matched Ingredient；
Preferably, the B1 group functional component, the B2 group functional component and the B3 group functional component be independently Including tetrahydro methylpyrimidine carboxylic acid, safflower seed oil, golden button extract, Astragalus membranacus root extract, ubiquinone, vitamin E and water Solve one or more of elastin laminin；
Preferably, the B1 group component includes: 0.5-1 parts of tetrahydro methylpyrimidine carboxylic acid, safflower seed oil 3-4 in parts by weight Part, golden 3-4 parts of button extract, 3-4 parts of Astragalus membranacus root extract, 3-4 parts of ubiquinone, 3-4 parts of vitamin E and hydrolyzed elastin 4-5 parts of albumen；
Preferably, the B2 group component includes: 0.2-0.5 parts of tetrahydro methylpyrimidine carboxylic acid, safflower seed oil in parts by weight 2-3 parts, golden 2-3 parts of button extract, 2-3 parts of Astragalus membranacus root extract, 2-3 parts of ubiquinone, 2-3 parts of vitamin E and hydrolysis bullet 2-4 parts of albumen of property；
Preferably, the B3 group component includes: 0.1-0.2 parts of tetrahydro methylpyrimidine carboxylic acid, safflower seed oil in parts by weight 1-2 parts, golden 1-2 parts of button extract, 1-2 parts of Astragalus membranacus root extract, 1-2 parts of ubiquinone, 1-2 parts of vitamin E and hydrolysis bullet 1-2 parts of albumen of property.
Preferably, skin pigment content is characterized with dermal melanin content MI value, if dermal melanin content MI value > 200, match C1 group functional component；If value≤200 dermal melanin content MI, C2 group functional component is matched；
Preferably, the C1 group component includes: 3-4 parts of Wild soybean albumen, Xylitol-based glucoside 1-3 in parts by weight Part, 1-3 parts of anhydro xylitol and 1-3 parts of xylitol；
Preferably, the C2 group component includes: 1-3 parts of Wild soybean albumen, Xylitol-based glucoside 1-3 in parts by weight Part, 1-3 parts of anhydro xylitol and 1-3 parts of xylitol.
Preferably, dermatoglyph degree is characterized with canthus line area, if canthus line area is > 20mm2, match D1 group effect Ingredient；If 15mm2The canthus < line area≤20mm2, match D2 group functional component；If canthus line area≤15mm2, match D3 group Functional component；
Preferably, the D1 group component includes: dipeptides diaminobutyryl benzyl amide diacetin 3-5 in parts by weight Part, 0.5-1 parts of kappaphycus algae extract, 0.5-1 parts of Caesalpinia spinosaKuntze berry extract, 3-5 parts of safflower seed oil, golden button extract 3- 5 parts, 3-5 parts of Astragalus membranacus root extract, 3-5 parts of ubiquinone and 3-5 parts of vitamin E；
Preferably, the D2 group component includes: dipeptides diaminobutyryl benzyl amide diacetin 2-3 in parts by weight Part, 0.3-0.5 parts of kappaphycus algae extract, 0.3-0.5 parts of Caesalpinia spinosaKuntze berry extract, 2-3 parts of safflower seed oil, golden button extract 2-3 parts of object, 2-3 parts of Astragalus membranacus root extract, 2-3 parts of ubiquinone and 2-3 parts of vitamin E；
Preferably, the D3 group component includes: dipeptides diaminobutyryl benzyl amide diacetin 1-2 in parts by weight Part, 0.1-0.3 parts of kappaphycus algae extract, 0.1-0.3 parts of Caesalpinia spinosaKuntze berry extract, 1-2 parts of safflower seed oil, golden button extract 1-2 parts of object, 1-2 parts of Astragalus membranacus root extract, 1-2 parts of ubiquinone and 1-2 parts of vitamin E.
Preferably, the eye skin care item are made after the functional component being mixed with matrix components；
Preferably, the matrix components include moisturizer, surfactant, thickener, dispersing agent, antioxidant, flavouring agent, One or more of emollient, anti-allergic agent, pH adjusting agent, filler, carrier and solvent.
Preferably, in parts by weight, the matrix components include: 1-2 parts of cetostearyl alcohol, 1-2 parts of cocoyl glucoside, 1-3 parts of stearine, 1-3 parts of PEG-100 stearate, 1-3 parts of Sucrose Polystearic Acid Esters, 1-3 parts of Parleam, 1-3 parts of cetanol, 1-3 parts of stearyl alcohol, 2-5 parts of oleyl alcohol eruciate, 2-5 parts of isononyl isononanoate, dimethyl silicone polymer 2-5 Part, 0.2-1 parts of tocopherol acetate, 0.1-0.5 parts of carbomer, 5-10 parts of glycerol, 5-10 parts of dipropylene glycol, 3-5 parts of propylene glycol, 3-5 parts of beta glucan, 0.1-0.5 parts of dipotassium glycyrrhizinate and 0.1-0.5 parts of aminomethyl propanol.
Preferably, the eye skin care item include eye cream, lotion, essence, toner or eye mask.
The present invention also provides a kind of eye maintenance methods, and the method includes using the system of above-mentioned customization eye skin care item The skin care item that Preparation Method is prepared nurse eye circumference skin.
Compared with prior art, the invention has the following beneficial effects:
The present invention provides a kind of method for customizing of eye skin care item, which includes the characterization according to customized objects The parameter of eye problems matches functional component, and the eye skin care item comprising the functional component are then made.Due to eye problems It is closely related with personal hereditary capacity, gender, age, life and working environment and living habit, therefore everyone eye Problem is all not quite similar, thousand people of existing eye skin care skin, one side, cannot be suitable for the eye problems of different users well.This Invention uses the eye part skin problem of parameter characterization customized objects, so that the eye part skin problem of customized objects can be more intuitive Reaction and measurement, then match corresponding functional component according to parameter, and the solution for being directed to the eye skin care item produced more determines The eye part skin problem of object processed.The inventive concept of method for customizing based on above-mentioned eye skin care item, the present invention also provides one Kind eye maintenance method, this method include the skin care item nursing being prepared using the preparation method of above-mentioned customization eye skin care item Eye circumference skin, this method can effectively alleviate eye circumference dry skin problem, restore eye circumference elasticity of skin and reduce wrinkle and Black eye.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is that the customization eye cream that the embodiment of the present invention 1 provides is become using canthus test zone moisture content change in 1-8 weeks Gesture；
Fig. 2 is that the customization eye cream that the embodiment of the present invention 1 provides uses canthus test zone moisture content change in 1-8 weeks Rate；
Fig. 3 is that the customization eye cream that the embodiment of the present invention 1 provides is changed using eye circumference test zone skin elasticity R2 in 1-8 weeks Trend；
Fig. 4 is that the customization eye cream that the embodiment of the present invention 1 provides is changed using eye circumference test zone skin elasticity in 1-8 weeks Rate；
Fig. 5 is that the customization eye cream that the embodiment of the present invention 1 provides uses canthus test zone skin elasticity R2, Q1 in 1-8 weeks Variation tendency；
Fig. 6 is that the customization eye cream that the embodiment of the present invention 1 provides uses canthus test zone skin elasticity R2, Q1 in 1-8 weeks Change rate；
Fig. 7 is that the customization eye cream that the embodiment of the present invention 1 provides is changed using eyeground test zone melanin content in 1-8 weeks Trend；
Fig. 8 is that the customization eye cream that the embodiment of the present invention 1 provides is changed using eyeground test zone melanin content in 1-8 weeks Rate；
Fig. 9 is that the customization eye cream that the embodiment of the present invention 1 provides uses eye circumference test zone skin smoothness SEsm in 1-8 weeks It is worth variation tendency；
Figure 10 is that the customization eye cream that the embodiment of the present invention 1 provides uses eye circumference test zone skin smoothness in 1-8 weeks SEsm value change rate；
Figure 11 is that the customization eye cream that the embodiment of the present invention 1 provides uses canthus line area change trend in 1-8 weeks；
Figure 12 is that the customization eye cream that the embodiment of the present invention 1 provides uses canthus line area change rate in 1-8 weeks；
Figure 13 is that the customization eye cream that the embodiment of the present invention 1 provides uses canthus line test zone Ra, Rt, Rz value in 1-8 weeks Variation tendency；
Figure 14 is that the customization eye cream that the embodiment of the present invention 1 provides uses canthus line test zone Ra, Rt, Rz value in 1-8 weeks Change rate；
Figure 15 is that the customization eye cream that the embodiment of the present invention 1 provides uses tear rill area change trend in 1-8 weeks；
Figure 16 is that the customization eye cream that the embodiment of the present invention 1 provides uses tear rill area change rate in 1-8 weeks；
Figure 17 is that the customization eye cream that the embodiment of the present invention 1 provides uses test zone tear rill Ra, Rt, Rz value in 1-8 weeks Variation tendency；
Figure 18 is that the customization eye cream that the embodiment of the present invention 1 provides uses test zone tear rill Ra, Rt, Rz value in 1-8 weeks Change rate.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention. The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same or instrument are not Production firm person is indicated, is the conventional products that can be obtained by commercially available purchase.
In the present invention, if without particularly illustrating, all embodiments mentioned in this article and preferred implementation method It can be combined with each other to form new technical solution.
In the present invention, if without particularly illustrating, all technical characteristics and preferred feature mentioned in this article can be with Intercombination forms new technical solution.
In the present invention, if percentage (%) or part refer to the weight relative to composition without particularly illustrating Percentage or parts by weight.
In the present invention, if related each component or its preferred ingredient can be combined with each other shape without particularly illustrating The technical solution of Cheng Xin.
In the present invention, unless otherwise indicated, numberical range " a-b " indicates the breviary of any real combinings between a to b It indicates, wherein a and b is real number.Such as numberical range " 6-22 " expression has all listed between " 6-22 " herein Whole real numbers, " 6-22 " are that the breviary of these combinations of values indicates.
" range " disclosed in this invention can be respectively one or more lower limits and one in the form of lower and upper limit A or multiple upper limits.
Unless otherwise indicated, profession used herein and meaning phase known to scientific term and one skilled in the art Together.In addition, any method similar to or equal to what is recorded or material can also be applied in the present invention.
The present invention provides a kind of method for customizing of eye skin care item, which includes the characterization according to customized objects The parameter of eye problems matches functional component, and the eye skin care item comprising the functional component are then made.Due to eye problems It is closely related with personal hereditary capacity, gender, age, life and working environment and living habit, therefore everyone eye Problem is all not quite similar, existing thousand people of eye skin care item, one side, cannot be suitable for the eye problems of different users well.This Invention uses the eye part skin problem of parameter characterization customized objects, so that the eye part skin problem of customized objects can be more intuitive Reaction and measurement, then match corresponding functional component, the solution customized objects for being directed to the eye cream produced more according to parameter Eye part skin problem.It should be noted that method of the invention is related to skin care field rather than therapeutic treatment field, because This present invention is not intended to diagnosis or any disease for the treatment of, and is intended to improve user's periocualr skin problem, as black eye, eye pouch, The problems such as crow's feet.
It is of the present invention characterization eye problems parameter detected optionally from instrument parameter, professional couple Quantifiable scoring or classification that the assessment of subject's eye problems obtains and for one of questionnaire of subject or A variety of detect it is preferable to use instrument of person obtains parameter, detected using instrument it is reproducible, and instrument detected value have it is unified Standard, the scope of application are more extensive.The parameter for the characterization eye problems that instrument detects for example can be but be not limited to moisture Content, MI value, EI value, fat content, skin elasticity R2 value, skin elasticity R5 value, skin elasticity R7 value, laser-Doppler value, One or more of wrinkle area and infrared value.
Skin problem is usually embodied in skin elasticity decline, wrinkle increases and deepens, and skin roughness is increased and moistened The several respects such as degree reduction, eye problems are also especially prominent at above-mentioned several aspects, therefore in some preferred embodiments, institute Stating eye problems includes one of moisture content of skin, skin pigment content, skin elasticity, dermatoglyph degree and skin smoothness Or it is a variety of, subject's eye can be directed to using the eye problems for the parameter characterization subject for measuring above-mentioned eye problems to match The effect of portion's problem ingredient.
It is preferably carried out in mode some, with skin moisture content MMV value characterization moisture content of skin, it is preferable to use skin Moisture content tester (Corneometer CM 825, Courage and Khazaka, Germany) detection moisture content of skin, should The probe of tester is that the principle based on capacitor measures.The dielectric constant of water is 81, and the dielectric constant of other substances is usual Less than 7, water is the maximum substance of dielectric constant on skin.When moisture content changes, the capacitance of skin also becomes Change, therefore can be by measuring skin pricktest capacitance, the water content on analyzing skin surface.Measured value is a relative value.Unit C.U. (Corneometer Units) is indicated.
If moisture content of skin be≤40C.U, such as can be but be not limited to 10C.U, 20C.U, 25C.U, 30C.U, 32C.U, 35C.U, 37.5C.U or 40C.U match A1 group functional component；If 40C.U < moisture content of skin≤60C.U, such as can Think but be not limited to 42C.U, 45C.U, 47.5C.U, 50C.U, 52.5C.U, 55C.U, 58C.U or 60C.U, matches A2 group function Imitate ingredient；If moisture content of skin > 60C.U, for example, can be but be not limited to 62.5C.U, 65C.U, 68C.U, 70C.U, 73C.U, 75C.U, 77.5C.U, 80C.U or 85C.U match A3 group functional component.
Preferably, A1 group functional component, A2 group functional component and A3 group functional component are independently to include containing slow The effect of solving moisture content of skin deficiency problem ingredient, ingredient for example can be the effect of the alleviation moisture content of skin deficiency problem One or more of but be not limited to ceramide, Xylitol-based glucoside, anhydro xylitol, xylitol.
It is preferably carried out in mode some, the A1 group component includes: -5 parts of Cer NP, xylose in parts by weight 5-6 parts of alcohol radical glucoside, 5-6 parts of anhydro xylitol and 5-6 parts of xylitol；Wherein, the parts by weight of ceramide for example can be with For but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of Xylitol-based glucoside for example can be but unlimited In being 5 parts, 5.2 parts, 5.5 parts, 5.8 parts or 6 parts；The parts by weight of anhydro xylitol for example can be but be not limited to 5 parts, 5.2 parts, 5.5 parts, 5.8 parts or 6 parts；The parts by weight of xylitol for example can be but be not limited to 5 parts, 5.2 parts, 5.5 parts, 5.8 parts or 6 parts.
It is preferably carried out in mode some, the A2 group component includes: -3 parts of Cer NS, xylose in parts by weight 3-5 parts of alcohol radical glucoside, 3-5 parts of anhydro xylitol and 3-5 parts of xylitol；Wherein, the parts by weight of ceramide for example can be with For but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.7 parts or 3 parts；The parts by weight of Xylitol-based glucoside for example can be but not It is limited to be 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of anhydro xylitol for example can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of xylitol for example can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts Or 5 parts.
It is preferably carried out in mode some, the A3 group component includes: -2 parts of Cer EOS, xylose in parts by weight 1-3 parts of alcohol radical glucoside, 1-3 parts of anhydro xylitol and 1-3 parts of xylitol；Wherein, the parts by weight of ceramide for example can be with For but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.8 parts or 2 parts；The parts by weight of Xylitol-based glucoside for example can be but not It is limited to be 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of anhydro xylitol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of xylitol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts Or 3 parts.
It is preferably carried out in mode some, detects skin elasticity, test equipment using skin elasticity tester MPA580 It is based on suction and to stretch former for skin elasticity tester (Cutometer dual MPA580, German CK company) test philosophy Reason generates a negative pressure in one fc-specific test FC probe of skin inspiration in tested skin surface, and skin is sucked into test Depth in probe is measured by a contactless optic testing system.Test probe in including light transmitter and The ratio (emitting the ratio between light and reception light) of receiver, light is directly proportional with the depth of skin is inhaled into, and then passes through MPA software point Analyse the elastic property to determine skin.Coefficient of skin elasticity R2 value, R5 value and R7 value can be obtained using MPA580: R2 is no negative pressure When skin springback capacity Ua and the ratio between maximum tension amount Uf when having a negative pressure；R5 is skin in the 1st cyclic process of skin test The elastic part Ur of skin recovery process and the ratio between the elastic part Ue for adding negative pressure process；R7 is that the 1st time of skin test is circulated throughout The ratio between the maximum tension amount Uf of the elastic part Ur of skin recovery process and skin in current cyclic process in journey.
It is preferred that skin elasticity is characterized with skin elasticity R2 value, if value≤0.5 skin elasticity R2, such as can be but be not limited to It is 0.1,0.2,0.3,0.4 or 0.5, matches B1 group functional component；If 0.5 value≤0.7 < skin elasticity R2, for example, can be but It is not limited to 0.5,0.55,0.6,0.65 or 0.7, matches B2 group functional component；If skin elasticity R2 value > 0.7, such as can be with For but be not limited to 0.7,0.75,0.8,0.85 or 0.9, match B3 group functional component.
Preferably, B1 group functional component, B2 group functional component and B3 group functional component are independently to include containing slow Solution skin lack flexibility problem the effect of ingredient, the alleviation skin lack flexibility problem the effect of ingredient for example can be but not It is limited in tetrahydro methylpyrimidine carboxylic acid, safflower seed oil, golden button extract, Astragalus membranacus root extract, ubiquinone and vitamin E One or more.
It is preferably carried out in mode some, the B1 group component includes: tetrahydro methylpyrimidine carboxylic acid in parts by weight 0.5-1 parts, 3-4 parts of safflower seed oil, golden 3-4 parts of button extract, 3-4 parts of Astragalus membranacus root extract, 3-4 parts of ubiquinone, dimension life Plain E 3-4 parts and elastin hydrolysis 4-5 parts；Wherein, the parts by weight of tetrahydro methylpyrimidine carboxylic acid for example can be but unlimited In being 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part；The parts by weight of safflower seed oil for example can be but be not limited to 3 parts, 3.2 parts, 3.5 parts, 3.75 parts or 4 parts；The parts by weight of golden button extract for example can be but be not limited to 3 parts, 3.2 Part, 3.5 parts, 3.75 parts or 4 parts；The parts by weight of Astragalus membranacus root extract for example can be but be not limited to 3 parts, 3.2 parts, 3.5 parts, 3.75 parts or 4 parts；The parts by weight of ubiquinone for example can be but be not limited to 3 parts, 3.2 parts, 3.5 parts, 3.75 parts or 4 Part；The parts by weight of vitamin E for example can be but be not limited to 3 parts, 3.2 parts, 3.5 parts, 3.75 parts or 4 parts；Hydrolyzed elastin The parts by weight of albumen for example can be but be not limited to 4 parts, 4.2 parts, 4.5 parts, 4.75 parts or 5 parts.
It is preferably carried out in mode some, the B2 group component includes: tetrahydro methylpyrimidine carboxylic acid in parts by weight 0.2-0.5 parts, 2-3 parts of safflower seed oil, golden 2-3 parts of button extract, 2-3 parts of Astragalus membranacus root extract, 2-3 parts of ubiquinone, dimension 2-3 parts and elastin hydrolysis 2-4 parts of raw element E.Wherein, the parts by weight of tetrahydro methylpyrimidine carboxylic acid for example can be but not It is limited to be 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part or 0.5 part；The parts by weight of safflower seed oil for example may be used Think but is not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；The parts by weight of golden button extract for example can be but It is not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；The parts by weight of Astragalus membranacus root extract for example can be but not It is limited to be 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；The parts by weight of ubiquinone for example can be but be not limited to 2 parts, 2.2 Part, 2.5 parts, 2.75 parts or 3 parts；The parts by weight of vitamin E for example can be but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；The parts by weight of elastin hydrolysis for example can be but be not limited to 2 parts, 2.5 parts, 3 parts, 3.5 parts or 4 Part.
It is preferably carried out in mode some, the B3 group component includes: tetrahydro methylpyrimidine carboxylic acid in parts by weight 0.1-0.2 parts, 1-2 parts of safflower seed oil, golden 1-2 parts of button extract, 1-2 parts of Astragalus membranacus root extract, 1-2 parts of ubiquinone, dimension 1-2 parts and elastin hydrolysis 1-2 parts of raw element E.Wherein, the parts by weight of tetrahydro methylpyrimidine carboxylic acid for example can be but not It is limited to be 0.1 part, 0.12 part, 0.15 part, 0.18 part or 0.2 part；The parts by weight of safflower seed oil for example can be but be not limited to It is 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts；The parts by weight of golden button extract for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts；The parts by weight of Astragalus membranacus root extract for example can be but be not limited to 1 part, 1.2 Part, 1.5 parts, 1.75 parts or 2 parts；The parts by weight of ubiquinone for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts Or 2 parts；The parts by weight of vitamin E for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts；Hydrolyze bullet The parts by weight of property albumen for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts.
It is preferably carried out in mode some, skin pigment content is characterized with dermal melanin content MI value, if melanin Index > 200, such as can be but be not limited to 210,220,230,240,250,260,270,280,290 or 300, matching C1 Group functional component；If melanin index≤200, such as can be but be not limited to 150,160,170,180,190 or 200, With C2 group functional component；
Preferably, C1 group functional component, C2 group functional component and C3 group functional component are independently to include containing subtracting The effect of few dermal melanin ingredient, ingredient for example can be but be not limited to Wild soybean the effect of the reduction dermal melanin One or more of albumen, Xylitol-based glucoside, anhydro xylitol and xylitol.
In some preferred embodiments, the C1 group component includes: 3-4 parts of Wild soybean albumen, wood in parts by weight 1-3 parts of sugar alcohol base glucoside, 1-3 parts of anhydro xylitol and 1-3 parts of xylitol.Wherein, the parts by weight of Wild soybean albumen are for example It can be but be not limited to 3 parts, 3.2 parts, 3.5 parts, 3.75 parts or 4 parts；The parts by weight of Xylitol-based glucoside for example can be with For but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of anhydro xylitol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of xylitol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts.
In some preferred embodiments, the C2 group component includes: 1-3 parts of Wild soybean albumen, wood in parts by weight 1-3 parts of sugar alcohol base glucoside, 1-3 parts of anhydro xylitol and 1-3 parts of xylitol.Wherein, the parts by weight of Wild soybean albumen are for example It can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of Xylitol-based glucoside for example can be but It is not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of anhydro xylitol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of xylitol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts Or 3 parts.
In some preferred embodiments, dermatoglyph degree is characterized with canthus line area, if canthus line area is > 20mm2, such as can be but be not limited to 21mm2、22mm2、23mm2、24mm2、25mm2、26mm2、27mm2、28mm2、29mm2 Or 30mm2, match D1 group functional component；If 15mm2The canthus < line area≤20mm2, such as can be but be not limited to 16mm2、 17mm2、18mm2、19mm2Or 20mm2, match D2 group functional component；If canthus line area≤15mm2, such as can be but unlimited In for 10mm2、11mm2、12mm2、13mm2、14mm2Or 5mm2, match D3 group functional component.
Preferably, D1 group functional component, D2 group functional component and D3 group functional component are independently to include containing slow The effect of solving canthus line problem ingredient, ingredient for example can be but be not limited to dipeptides two the effect of the alleviation canthus line problem Aminobutyryl benzyl amide diacetin, kappaphycus algae extract, Caesalpinia spinosaKuntze berry extract, safflower seed oil, golden button extract Object, Astragalus membranacus root extract and one or more of ubiquinone and vitamin E.
In some preferred embodiments, the D1 group component includes: dipeptides diaminobutyryl benzyl in parts by weight 3-5 parts of amide diacetin, 0.5-1 parts of kappaphycus algae extract, 0.5-1 parts of Caesalpinia spinosaKuntze berry extract, safflower seed oil 3-5 Part, golden 3-5 parts of button extract, 3-5 parts of Astragalus membranacus root extract, 3-5 parts of ubiquinone and 3-5 parts of vitamin E.Wherein, dipeptides The parts by weight of diaminobutyryl benzyl amide diacetin for example can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of kappaphycus algae extract for example can be but be not limited to 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 Part or 1 part；The parts by weight of Caesalpinia spinosaKuntze berry extract for example can be but be not limited to 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part；The parts by weight of safflower seed oil for example can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；Gold The parts by weight of button extract for example can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；Astragalus membranacus root mentions Taking the parts by weight of object for example can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of ubiquinone are for example It can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of vitamin E for example can be but be not limited to It is 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts.
In some preferred embodiments, the D2 group component includes: dipeptides diaminobutyryl benzyl in parts by weight 2-3 parts of amide diacetin, 0.3-0.5 parts of kappaphycus algae extract, 0.3-0.5 parts of Caesalpinia spinosaKuntze berry extract, safflower seed oil 2-3 parts, golden 2-3 parts of button extract, 2-3 parts of Astragalus membranacus root extract, 2-3 parts of ubiquinone and 2-3 parts of vitamin E.Wherein, The parts by weight of dipeptides diaminobutyryl benzyl amide diacetin for example can be but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；The parts by weight of kappaphycus algae extract for example can be but be not limited to 0.3 part, 0.35 part, 0.4 part, 0.45 part or 0.5 part；The parts by weight of Caesalpinia spinosaKuntze berry extract for example can be but be not limited to 0.3 part, 0.35 part, 0.4 part, 0.45 part or 0.5 part；The parts by weight of safflower seed oil for example can be but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 Part；The parts by weight of golden button extract for example can be but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；Film pod The parts by weight of Radix Astragali root extract for example can be but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；Ubiquinone Parts by weight for example can be but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts；The parts by weight of vitamin E are for example It can be but be not limited to 2 parts, 2.2 parts, 2.5 parts, 2.75 parts or 3 parts.
In some preferred embodiments, the D3 group component includes: dipeptides diaminobutyryl benzyl in parts by weight 1-2 parts of amide diacetin, 0.1-0.3 parts of kappaphycus algae extract, 0.1-0.3 parts of Caesalpinia spinosaKuntze berry extract, safflower seed oil 1-2 parts, golden 1-2 parts of button extract, 1-2 parts of Astragalus membranacus root extract, 1-2 parts of ubiquinone and 1-2 parts of vitamin E.Wherein, The parts by weight of dipeptides diaminobutyryl benzyl amide diacetin for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts；The parts by weight of kappaphycus algae extract for example can be but be not limited to 0.1 part, 0.15 part, 0.2 part, 0.25 part or 0.3 part；The parts by weight of Caesalpinia spinosaKuntze berry extract for example can be but be not limited to 0.1 part, 0.15 part, 0.2 part, 0.25 part or 0.3 part；The parts by weight of safflower seed oil for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 Part；The parts by weight of golden button extract for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts；Film pod The parts by weight of Radix Astragali root extract for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts；Ubiquinone Parts by weight for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts；The parts by weight of vitamin E are for example It can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.75 parts or 2 parts.
It should be noted that A1 group, A2 group, A3 group, B1 group, B2 group, B3 group, C1 group, C2 group, D1 in above embodiment Group, D2 group and D3 group are only intended to the grouping of corresponding different efficacies ingredient under difference different parameters, are used for description purposes only, and It cannot be understood as indicating or implying relative importance.
The effect of above-mentioned use, ingredient had the following beneficial effects: that ceramide is the main component of horny layer of epidermis, had There is maintenance skin barrier, keep moisture of skin, reinforce skin anti-aging function, skin is enabled to keep elasticity, it is smooth careful, reduce face The effect that portion's wrinkle is formed.Xylitol-based glucoside, anhydro xylitol and xylitol are good moisturizer, can improve skin Skin moisture content reduces water loss while improving the moisture content of epidermis；Also have and promotes hyaluronic acid and chondroitin sulfate Cellulose content increases, and promotes ceramide synthesis, and enhancing skin barrier effect has both moisturizing and anti-ageing effect.Tetrahydro methyl is phonetic Pyridine carboxylic acid is a kind of natural maintenance cell protecting factor, can adjust cell water balance, forms water lock film, lock in skin surface Firmly skin moisture maintains skin humidity, softness and smoothness, and also there is protection cell and enhancing cell resistance UV light temperature to make With.Safflower seed oil is that have using the seed of safflower (CARTHAMUS TINCTORIUS) as the oil product of waste and promote skin new City metabolism, promotes skin to restore effect of elasticity；Safflower seed oil or a kind of natural, it to human body cell divide, Anti-aging important role；Safflower seed oil is suitble to various skin quality, has pore refining, and dry skin is alleviated in skin whitening, The effect of repairing the skin and delay skin aging of sunburn.Golden button (SPILANTHES ACMELLA) be composite family, Spilanthes, Quasi- Spilanthes oleracea kind plant, gold button extract of the present invention are at least one of golden bachelor's button, leaf and extract of stem, The isobutylamides and great active spilanthol that golden button extract is rich in, by the biomethanics function for intensifying fibrocyte Can, to reform the structure of corium, promote the density of skin and the degree of packing rapidly, reduces the roughness of skin, smooth skin Activity, can quickly reduce canthus fishtail line, there is effective crease-resistant effect, can effectively inhibit tyrosinase activity and black The synthesis of element achievees the effect that improve skin pigmentation and skin whitening.Astragalus membranacus (ASTRAGALUS MEMBRANACEUS) root extract is containing the lot of trace member such as saponin, sucrose, polysaccharide, a variety of amino acid, folic acid and selenium, zinc, copper Element: the physiological metabolism of cell can be made to act on enhancing, stimulate the proliferation of Skin Cell, there is conditioning skin and wrinkle resistant anti-ageing work With.Ubiquinone, also known as ubiquinone (CoQ), for a kind of fat-soluble quinones, ubiquinone has crease-resistant effect, has anti-oxidant, clear Except free radical, stablize the effects of biomembrane.Vitamin E: can effectively clear oxygen radical, and anti-lipid peroxidation can effectively subtract The formation of few pigment deposition and color spot has wrinkle resistant, water lock, promotes absorption and anti-wrinkle effect.Elastin hydrolysis: elastic egg White is the main component of elastomer in rawhide tissue, and elastin laminin plays the part of the role of rubber band in skin, allows skin to have and stretches The ability of exhibition and flatung.Elastin laminin molecular weight after hydrolysis is smaller, skin can be promoted adequately to absorb, and increases skin collagen egg White and elastin laminin content, significantly improves skin inner tensions and elastic force, reinforces the collagen activity of skin, keeps cutin Moisture, improvement from inside to outside simultaneously reduce wrinkle, improve compact sense, increase the effect of skin elasticity is to delay senescence.It is wild big Legumin has nti-freckle and oxidation resistant effect with that can significantly reduce melanin, bright color.Dipeptides diaminobutyryl benzyl Base amide diacetin is small molecule tripeptides, and activity has been imitated the activity of protein Waglerin-1 in the Pallas pit viper venom of mausoleum, can have been hindered Neurotransmission on disconnected acetylcholinergic receptor, to loosen pseudo wrinkle.It can imitate to anti-wrinkle, especially Eradicates except expression Line, smooth wrinkle, facial muscles are loosened in help, while not influencing facial expression.Kappaphycus alvarezi (KAPPAPHYCUS ALVAREZII) extract is under the jurisdiction of Rhodophyta, Rhodophyceae, Gigartinales, solieria section, Kappa Trentepohlia, and extract contains abundant Galactan sulfate, can smooth face and body immediately skin nan orelief, quickly and persistently desalinate wrinkle, reach immediately flat The effect of sliding firm skin has effects that extend the skin service life and delays its naturally-aged process；It can also melanin processed It generates, and has the function of anti-oxidant and moisturizing whitening.Caesalpinia spinosaKuntze (CAESALPINIA SPINOSA) berry extract contains abundant Galactomannans, flexible and non-blocking film can be formed in skin surface, there is compact lifting skin and instant crease-resistant Effect.Also, on the basis of the effect of effect ingredient in above-mentioned each group component respectively, by reasonable in present embodiment The dosage of effect ingredient and reasonably combined each component in selection each group component, which makes it also, has the function of synergy；Simultaneously In the present embodiment the collocation also according to the Rational Parameters of subject's eye problems and pick functional component and effect at The dosage divided is so that the eye skin care item after collocation can more effectively solve the eye problems of subject.By adjusting and optimization The selection of ingredient in each group component and the proportion of dosage can advanced optimize the using effect of customization eye skin care item.
In some alternative embodiments, the eye skin care is made after the functional component being mixed with matrix components Product, the production method of eye skin care item of the present invention, may be selected existing routine techniques in manufacture craft, such as plus Heat, stirring and homogeneous etc., the present invention to production method with no restrictions.
In some preferred embodiments, the matrix components include moisturizer, surfactant, thickener, dispersion One or more of agent, antioxidant, flavouring agent, emollient, anti-allergic agent, pH adjusting agent, filler, carrier and solvent.? In some preferred embodiments, in parts by weight, the matrix components include: 1-2 parts of cetostearyl alcohol, cocoyl glucoside 1-2 parts, 1-3 parts of stearine, 1-3 parts of PEG-100 stearate, 1-3 parts of Sucrose Polystearic Acid Esters, Parleam 1-3 parts, 1-3 parts of cetanol, 1-3 parts of stearyl alcohol, 2-5 parts of oleyl alcohol eruciate, 2-5 parts of isononyl isononanoate, polydimethylsiloxanes 2-5 parts of alkane, 0.2-1 parts of tocopherol acetate, 0.1-0.5 parts of carbomer, 5-10 parts of glycerol, 5-10 parts of dipropylene glycol, propylene glycol 3-5 parts, 3-5 parts of beta glucan, 0.1-0.5 parts of dipotassium glycyrrhizinate and 0.1-0.5 parts of aminomethyl propanol.
Wherein, the parts by weight of cetostearyl alcohol for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.8 parts or 2 Part；The parts by weight of cocoyl glucoside for example can be but be not limited to 1 part, 1.2 parts, 1.5 parts, 1.8 parts or 2 parts；Glycerol The parts by weight of stearate for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；PEG-100 stearic acid The parts by weight of ester for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The weight of Sucrose Polystearic Acid Esters Number for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of Parleam for example may be used Think but is not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of cetanol for example can be but be not limited to 1 Part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；The parts by weight of stearyl alcohol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 Part or 3 parts；The parts by weight that 1-3 parts of stearyl alcohol for example can be but be not limited to 1 part, 1.5 parts, 2 parts, 2.5 parts or 3 parts；Oil The parts by weight of alcohol eruciate for example can be but be not limited to 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；Different nonyl The parts by weight of the different nonyl ester of acid for example can be but be not limited to 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；Poly- two The parts by weight of methylsiloxane for example can be but be not limited to 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；It is raw Educate phenol acetic acid esters parts by weight for example can be but be not limited to 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part；The parts by weight of carbomer for example can be but be not limited to 0.1 part, 0.2 part, 0.3 part, 0.4 part With 0.5 part；The parts by weight of glycerol for example can be but be not limited to 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts；Dipropylene glycol Parts by weight for example can be but be not limited to 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts；The parts by weight of propylene glycol are for example It can be but be not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of beta glucan for example can be but be not limited to It is 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts；The parts by weight of dipotassium glycyrrhizinate for example can be but be not limited to 0.1 part, 0.2 Part, 0.3 part, 0.4 part and 0.5 part；The parts by weight of aminomethyl propanol for example can be but be not limited to 0.1 part, 0.2 part, 0.3 Part, 0.4 part and 0.5 part.By adjusting the selection and proportion of matrix components, the dosage form and enhancing skin of eye skin care item can adjust Absorption to wherein functional component.
In some alternative embodiments, can according to specify multinomial use habit and eye problems by eye skin care Eye cream, lotion, essence, toner or eye mask is made in product, to adapt to the demand of different crowd.
The present invention also provides a kind of eye maintenance method, this method is included in eye circumference and smears using above-mentioned customization eye shield The skin care item that the preparation method of skin product is prepared.The preparation method base of the eye maintenance method and above-mentioned customization eye skin care item In identical inventive concept, all beneficial effects of the preparation method with above-mentioned customization eye skin care item, details are not described herein.
Beneficial effects of the present invention are further illustrated below with reference to preferred embodiment.
The test method that the parameter of eye part skin problem is respectively characterized in embodiment and comparative example is as follows:
Skin moisture content MMV value uses skin moisture content tester (Corneometer CM 825, Courage And Khazaka, Germany) measurement；Skin elasticity uses skin elasticity tester (Cutometer dual MPA580, German CK Company) measurement.
Pigment content, skin shine, skin elasticity and the skin smoothness of periocualr skin use VISIA skin detection instrument Detection, to avoid the accuracy for influencing to test, it is necessary to after keeping skin of face noresidue dressing, sit quietly in constant-temperature constant-humidity environment 20-30min makes skin be restored to normal physiological status.Broken hair is cleared up, headgear is taken, prevents broken hair from influencing detection data.? It in constant-temperature constant-humidity environment, after user head is fixed, takes pictures to the positive face of the user, analyzes eye part skin situation.It uses The ultra high-definition camera of detecting instrument VISIA, by white light, polarised light, ultraviolet light imaging, by the spot of eye part skin, wrinkle, The problems such as color spot, skin turgor, veins beneath the skin, is presented, thus obtain the skin pigment content of periocualr skin, skin shine, Skin elasticity, skin smoothness.
Skin pigment content: the principle (RGB) based on spectral absorption, by measuring the illumination of specific wavelength in human skin Volume reflection after upper determines the content of melanin and ferroheme in skin.Dermal melanin content MI value measurement numerical value is higher, Illustrate that melanin content is higher in skin.Skin content of hemachrome EI measurement numerical value is higher, illustrates blood red pigment content in skin It is higher.Unit: dimensionless.
Dermatoglyph degree: skin instant imaging analysis system Derma TOP uses fringe projection measuring technique (Fringe Projection the wrinkle of skin) is detected.It is a kind of non-contacting method for fast measuring, and it is rapid-result fastly to can be carried out three-dimensional cutaneous Picture completes measurement using blue-light source in one second.VISIOFACE V4 by head sensor, two ear sensors and Facial laser positioning function makes Derma TOP system have the secondary positioning function of extraordinary face.Unit: mm.
Ra value is arithmetic average roughness, refers on purported skin straight line grey scale curve to the range averaging of average gray value Value.I.e. within the scope of straight length, the arithmetic of absolute value of each point to profile middle line distance is flat on tested skin surface contours line Mean value.
Rt value skin roughness, in all sections of skin, between gray scale peak value maximum on straight line and minimal gray peak value Difference.The parameter is the maximum height of skin surface unevenness, i.e., top is to the height between lowest trough in measuring section.
Rz value skin mean roughness, in the arithmetic equal value of the baseline upper and lower skin mound profile of purported skin, i.e., in the limit In section, it is divided into 5 equal parts by the limitation of length, finds out every section first with skin mound under skin mound profile (maximum gradation value) on baseline and baseline Difference between profile (minimum gradation value), i.e. skin roughness ask the roughness average in the length baseline (to calculate again later Art average value) it is skin mean roughness.This parameter and the number of wrinkle of skin are how many, thickness, the depth have close relationship.
Image analysis: application face image analysis system VISIA-CR carries out Image Acquisition to subject, at image Reason enhancing analysis system Image-Plus Chinese Version 7.0.1 draws in face-image and takes equivalent surface area Carry out correlation analysis.
Skin smoothness: test equipment is skin microscope and viable skin surface analysis system (VisioScan VC98USB, German CK company), test equipment is tested by the skin image CCD with ultraviolet source in a special probe System is tested in skin surface, can be obtained by the activated state image of skin in this way.This black-and-white video signal is inputted It is handled, then is input in computer into the digitizer of test macro, it is soft by dedicated viable skin surface assessment Part SELS, which carries out analysis, can be obtained by the numerical parameter of evaluation viable skin surface appearance.SEsm value characterizes smoothness, more flat Sliding skin is narrower on the histogram picture traverse of intensity profile, and numerical value is smaller.
Embodiment 1
Moisture content of skin, skin elasticity R2 value, melanin content MI value and the canthus line area of test subject, is tied Fruit is as follows:
Moisture content of skin: 59.63C.U；Periocualr skin elasticity R2 value: 0.5328；Canthus skin elasticity R2 value: 0.5995；It is black Pigment content MI value: 202.87；Canthus line area: 24.94mm2；
The effect of obtaining formula composition proportion is as follows: .5 parts of Cer NS, 6 parts of Xylitol-based glucoside, anhydro xylitol 6 parts, 6 parts of xylitol, 0.5 part of tetrahydro methylpyrimidine carboxylic acid, 5 parts of safflower seed oil, golden 5 parts of button extract, Astragalus membranacus root mention Take 5 parts of object, 3 parts of ubiquinone, 3 parts of vitamin E, 3 parts of elastin hydrolysis, 3.5 parts of Wild soybean albumen, dipeptides diaminobutyryl benzyl 4 parts of base amide diacetin, 0.8 part of kappaphycus algae extract, 0.8 part of Caesalpinia spinosaKuntze berry extract；
Matrix components are as follows: 1.5 parts of cetostearyl alcohol, 1.5 parts of cocoyl glucoside, 2 parts of stearine, PEG- 100 2 parts of stearates, 2 parts of Sucrose Polystearic Acid Esters, 2 parts of Parleam, 2 parts of cetanol, 2 parts of stearyl alcohol, oleyl alcohol erucic acid 4 parts of ester, 4 parts of isononyl isononanoate, 3.5 parts of dimethyl silicone polymer, 1 part of tocopherol acetate, 0.5 part of carbomer, glycerol 10 Part, 8 parts of dipropylene glycol, 4 parts of propylene glycol, 4 parts of beta glucan, 0.4 part of dipotassium glycyrrhizinate and 0.4 part of aminomethyl propanol.
Above-mentioned functional component and matrix components are made to customization eye cream after mixing.Application method: it after morning and evening clean skin, takes Soya bean size is applied to eye circumference, is massaged into absorption.Subject pays a return visit the time: the 0th week, the 1st week, the 2nd week, the 4th week, the 8th week.
Effect example 1 improves canthus skin moisture content effect
Test method:
Skin moisture content MMV value, value is bigger, and moisture content is bigger, conversely, moisture content is smaller.Hydration rate becomes Rate, this value is higher, and moisturizing effect is more obvious.
The results are shown in Table 1 for skin moisture content MMV Data-Statistics；Subject's test area skin moisture changes of contents trend And change rate is as depicted in figs. 1 and 2, wherein * indicates p < 0.05, i.e., there were significant differences with the 0th week.It can be with by table 1, Fig. 1 and Fig. 2 Find out, within 8 weeks test periods, after subject uses test sample, canthus test area skin moisture content is used with sample Time gradually rises, and is above at the 1st week, the 2nd week, the 4th week and the 8th week before use, and there are significant difference (p < 0.05)； Canthus test zone skin hydration rate was positive value at the 1st week, the 2nd week, the 4th week and the 8th week, and was increased with sample using the time Add and increase, reaches 26.01% in the 8th week canthus improvement rate；Described above, test sample can significantly improve canthus region skin Skin moisture content, and using having positive effect (p < 0.05) after sample 1 week, be used continuously 8 weeks lasts significantly (p < 0.05)。
The statistical result of 1 skin moisture content MMV value of table
Skin moisture content 0th week 1st week 2nd week 4th week 8th week
Mean value 59.63 68.56 69.55 70.50 74.05
SD value 8.77 8.93 8.01 7.07 7.17
△ difference / 8.93 9.92 10.87 14.42
Change rate (%) / 16.25 17.87 19.84 26.01
Significance analysis / p<0.05 p<0.05 p<0.05 p<0.05
Note: it is replaced by vacancy with "/" in table
Effect example 2 improves periocualr skin elasticity
For skin elasticity R2 value closer to 1, skin elasticity is better；The change rate of R2 value is higher, and sample improves skin elasticity Effect is better.The results are shown in Table 2 for subjects skin elasticity R2 Data-Statistics；Subject is surveyed using eye circumference after customization eye cream 1-8 weeks Try area skin elasticity R2 variation tendency and skin elasticity change rate result it is as shown in Figure 3 and Figure 4, wherein wherein * indicate p < 0.05, i.e., there were significant differences with the 0th week.It can be seen from table 2, Fig. 3 and Fig. 4 within 8 weeks test periods, subject uses survey After test agent, eye circumference test zone skin elasticity R2 value is gradually risen with sample using the time, hence it is evident that is higher than before use, and existing Significant difference (p < 0.05)；The change rate of eye circumference test zone skin elasticity R2 value was at the 1st week, the 2nd week, the 4th week and the 8th week Shi Junwei positive value reaches 25.59% in the 8th week eye circumference improvement rate；Described above, test sample can significantly improve periocular area Skin elasticity, and using having positive effect (p < 0.05) after sample 1 week, it is significant (p < 0.05) that 8 weeks lasts are used continuously.
The statistical result of 2 periocualr skin elasticity R2 of table
R2 value 0th week 1st week 2nd week 4th week 8th week
Mean value ± SD value 0.5328 0.5841 0.5713 0.5930 0.6572
SD value 0.0740 0.0600 0.0554 0.0601 0.0693
△ difference / 0.0513 0.0385 0.0602 0.1244
Change rate (%) / 11.40 9.05 13.47 25.59
Significance analysis / p<0.05 p<0.05 p<0.05 p<0.05
Note: it is replaced by vacancy with "/" in table
Effect example 3 improves canthus skin elasticity
For skin elasticity R2 value closer to 1, skin elasticity is better；The change rate of R2 value is higher, and sample improves skin elasticity Effect is better；For skin elasticity Q1 value closer to 1, skin elasticity is better；The change rate of Q1 value is higher, and sample improves skin elasticity Effect is better.Subject is as shown in table 3 using the statistical result of customization 1-8 weeks canthus coefficient of skin elasticity of eye cream, canthus test Area skin elasticity R2, Q1 variation tendency and change rate are as shown in Figure 5 and Figure 6, wherein * indicate p < 0.05, i.e., with the 0th Zhou Youxian Write difference.It can be seen from table 3, Fig. 5 and Fig. 6 within 8 weeks test periods, after subject uses test sample, canthus test section Domain skin elasticity Q1 value, R2 value are gradually risen with sample using the time, hence it is evident that higher than before use, and there are significant difference (p < 0.05)；Canthus test zone skin elasticity Q1 value, R2 value change rate be positive the 1st week, the 2nd week, the 4th week and the 8th Zhou Shijun Value, and increased with sample using the time and increased, reach 17.09%, Q1 value improvement rate in the 8th week canthus R2 value improvement rate and reaches 21.11%；Described above, test sample can significantly improve canthus area skin elasticity, and obvious using having after sample 2 weeks It is significant (p < 0.05) that 8 weeks lasts are used continuously in effect (p < 0.05).
The statistical result of 3 canthus coefficient of skin elasticity of table
Note: it is replaced by vacancy with "/" in table
4 Vitamin K effect of effect example
MI value is dermal melanin content, and EI value is skin content of hemachrome, and numerical value is bigger, and pigment content is higher；MI value, EI value change rate, this value is lower, and sample reduces eyeground dermal melanin and the effect of ferroheme is better, Vitamin K effect It is more obvious.Subject is as shown in table 4 using eyeground test zone melanin content statistical result in customization eye cream 1-8 weeks, eyeground Test zone melanin content variation tendency and change rate are as shown in Figure 7 and Figure 8, and wherein * indicates p < 0.05, i.e., had with the 0th week Significant difference.It can be seen from table 4, Fig. 7 and Fig. 8 within 8 weeks test periods, after subject uses test sample, eyeground test Area skin melanin content MI value and content of hemachrome EI value are gradually decreased with sample using the time, hence it is evident that lower than use Before, and there are significant difference (p < 0.05)；The change rate of MI value and EI value was in the 1st week, the 2nd week, the 4th week and the 8th Zhou Shijun For negative value, and increased with sample using the time and reduced, it is (absolute to reach 15.92% in the 8th week eyeground dermal melanin improvement rate Value), skin ferroheme improvement rate reaches 4.69% (absolute value)；It is described above, test sample reduce eyeground dermal melanin and Content of hemachrome, the effect of Vitamin K are obvious (p < 0.05).
4 eyeground test zone melanin content statistical result of table
Note: it is replaced by vacancy with "/" in table
The smooth skin effect of effect example 5
SEsm value characterizes smoothness, and more smooth skin is narrower on the histogram picture traverse of intensity profile, and numerical value is smaller. SEsm value change rate is lower, and the smooth skin effect of test sample is better.Subject is flat using periocualr skin in customization eye cream 1-8 weeks The results are shown in Table 5 for slippery SEsm Data-Statistics, eye circumference test zone skin smoothness SEsm value variation tendency and change rate such as Fig. 9 With shown in Figure 10, wherein * indicates p < 0.05, i.e., there were significant differences with the 0th week.It is being tested it can be seen from table 5, Fig. 9 and Figure 10 In 8 weeks periods, after subject uses test sample, eye circumference test zone skin smoothness SEsm value was the 1st week, the 2nd week, the 4th Lower than before use, and there are significant difference (p < 0.05) at the 4th week and the 8th week when week and the 8th week；Skin smoothness SEsm value Change rate be negative value at the 1st week, the 2nd week, the 4th week and the 8th week, in changing for the 8th week periocualr skin smoothness SEsm value Kind rate reaches 8.00% (absolute value)；Described above, the effect of the smooth skin of test sample is obvious, and is using after sample 4 weeks Have positive effect (p < 0.05), it is significant (p < 0.05) that 8 weeks lasts are used continuously.
5 periocualr skin smoothness SEsm Data-Statistics result of table
Skin smoothness 0th week 1st week 2nd week 4th week 8th week
Mean value ± SD value 150.73±42.99 144.06±39.68 137.95±38.68 135.67±37.23 134.69±30.11
△ difference / -6.67 -12.78 -15.06 -16.04
Change rate (%) / -2.79 -6.17 -7.76 -8.00
Significance analysis / p>0.05 p>0.05 p<0.05 p<0.05
Note: it is replaced by vacancy with "/" in table
Effect example 6 desalinates canthus line effect
VISIA-CR analyzes result: canthus line area, numerical value is lower, illustrates that selected areas inner eye corner line area is smaller, eye The change rate of angle line area is lower, and it is better that sample desalinates canthus line effect.Subject uses canthus line face in customization eye cream 1-8 weeks Product statistical result it is as shown in table 6, canthus line area change trend and change rate as is illustrated by figs. 11 and 12, wherein * indicate p < 0.05, i.e., there were significant differences with the 0th week.It can be seen from table 6, Figure 11 and Figure 12 within 8 weeks test periods, subject is used After test sample, canthus line area is at the 1st week, the 2nd week, the 4th week and the 8th week lower than before use, and the 4th week and the 8th week There are significant difference (p < 0.05)；The change rate of canthus line area was negative the 1st week, the 2nd week, the 4th week and the 8th Zhou Shijun Value, reaches 10.35% (absolute value) in the improvement rate of the 8th week eye circumference canthus line area；Described above, test sample desalinates canthus The effect of line is obvious, and using having positive effect (p < 0.05) after sample 4 weeks, be used continuously 8 weeks lasts significantly (p < 0.05)。
6 canthus line area statistics result of table
Tear rill area 0th week 1st week 2nd week 4th week 8th week
Mean value ± SD value 24.94±12.09 23.93±11.77 23.28±11.61 21.61±10.12 20.92±9.88
△ difference / -1.01 -1.66 -3.33 -4.02
Change rate (%) / -2.63 -7.33 -12.89 -12.45
Significance analysis / p>0.05 p<0.05 p<0.05 p<0.05
Note: it is replaced by vacancy with "/" in table
Derma TOP analyzes result: Ra value is arithmetic average roughness, and Rt value is skin roughness, and Rz value is flat for skin Equal roughness, numerical value is lower, and dermatoglyph degree is lower, and change rate is lower, and it is better that sample improves wrinkle of skin effect.Subject makes It the results are shown in Table as shown in table 7 with canthus line test zone Ra, Rt, Rz Data-Statistics in customization eye cream 1-8 weeks, canthus line test zone Ra, Rt, Rz value variation tendency and change rate are as shown in Figure 13 and Figure 14, and wherein * indicates p < 0.05, i.e., had significance difference with the 0th week It is different.It can be seen from table 7, Figure 13 and Figure 14 within 8 weeks test periods, after subject uses test sample, canthus line Ra, Rt, Rz value at the 1st week, the 2nd week, the 4th week and the 8th week be lower than before use, and the 4th week and the 8th week there are significant difference (p < 0.05)；The change rate of canthus line Ra, Rt, Rz value was negative value at the 1st week, the 2nd week, the 4th week and the 8th week, in the 8th week eye The improvement rate of angle line Ra value, Rt value and Rz value is respectively 9.90%, 7.87% and 8.72% (absolute value)；It is described above, test The effect that sample desalinates canthus line is obvious, and using having positive effect (p < 0.05) after sample 4 weeks, 8 weeks effects are used continuously Continue significant (p < 0.05).
7 canthus line test zone Ra, Rt, Rz Data-Statistics result of table
Note: it is replaced by vacancy with "/" in table
Effect example 7 desalinates tear rill
VISIA-CR analyzes result: tear rill area, numerical value is lower, illustrates that tear rill area is smaller in selected areas, tear The change rate of rill area is lower, and it is better that sample desalinates tear rill effect.Subject uses tear rill face in customization eye cream 1-8 weeks Product statistical result it is as shown in table 8, tear rill area change trend and change rate are as shown in Figure 15 and Figure 16, wherein * indicate p < 0.05, i.e., there were significant differences with the 0th week.It can be seen from table 8, Figure 15 and Figure 16 within 8 weeks test periods, subject is used After test sample, tear rill area at the 1st week, the 2nd week, the 4th week and the 8th week be lower than before use, and at the 2nd week, the 4th week and There are significant difference (p < 0.05) within 8th week；The change rate of tear rill area was the 1st week, the 2nd week, the 4th week and the 8th Zhou Shijun For negative value, reach 12.45% (absolute value) in the improvement rate of the 8th week eye circumference tear rill area；It is described above, test sample desalination The effect of tear rill is obvious, and using having positive effect (p < 0.05) after sample 4 weeks, 8 weeks lasts of continuous use are significant (p<0.05)。
8 tear rill area statistics result of table
Tear rill area 0th week 1st week 2nd week 4th week 8th week
Mean value ± SD value 24.94±12.09 23.93±11.77 23.28±11.61 21.61±10.12 20.92±9.88
△ difference / -1.01 -1.66 -3.33 -4.02
Change rate (%) / -2.63 -7.33 -12.89 -12.45
Significance analysis / p>0.05 p<0.05 p<0.05 p<0.05
Note: it is replaced by vacancy with "/" in table
Derma TOP analyzes result: Ra value is arithmetic average roughness, and Rt value is skin roughness, and Rz value is flat for skin Equal roughness, numerical value is lower, and dermatoglyph degree is lower, and change rate is lower, and it is better that sample improves wrinkle of skin effect.Subject makes It the results are shown in Table as shown in table 9 with tear rill test zone Ra, Rt, Rz Data-Statistics in customization eye cream 1-8 weeks, tear rill test zone Ra, Rt, Rz value variation tendency and change rate are as shown in Figure 17 and Figure 18, and wherein * indicates p < 0.05, i.e., had significance difference with the 0th week It is different.It can be seen from table 9, Figure 17 and Figure 18 within 8 weeks test periods, after subject uses test sample, tear rill Ra, Rt, Rz value was lower than at the 1st week, the 2nd week, the 4th week and the 8th week before use, and that at the 2nd week, the 4th week and the 8th week, there are conspicuousnesses was poor Different (p < 0.05)；The change rate of tear rill Ra, Rt, Rz value was negative value at the 1st week, the 2nd week, the 4th week and the 8th week, the 8th The improvement rate of all tear rill Ra values, Rt value and Rz value is respectively 13.06%, 14.50% and 12.69% (absolute value)；It says above Bright, the effect that test sample desalinates tear rill is obvious, and using having positive effect (p < 0.05) after sample 2 weeks, is used continuously 8 All lasts are significant (p < 0.05).
9 tear rill test zone Ra, Rt, Rz Data-Statistics result of table
Note: it is replaced by vacancy with "/" in table
Embodiment 2
Moisture content of skin, skin elasticity R2 value, melanin content MI value and the canthus line area of test subject, is tied Fruit is as follows:
Moisture content of skin: 75.45C.U；Periocualr skin elasticity R2 value: 0.7664；Canthus skin elasticity R2 value: 0.7784；It is black Pigment content MI value: 236.45；Canthus line area: 11.84mm2；
The effect of obtaining formula composition proportion is as follows: Cer EOS part, 3 parts of Xylitol-based glucoside, anhydro xylitol 3 Part, 3 parts of xylitol, 0.1 part of tetrahydro methylpyrimidine carboxylic acid, 1 part of safflower seed oil, golden 1 part of button extract, Astragalus membranacus root extract 1 part of object, 1 part of ubiquinone, 1 part of vitamin E, 1 part of elastin hydrolysis, 4 parts of Wild soybean albumen, dipeptides diaminobutyryl benzyl acyl 1 part of amine diacetin, 0.15 part of kappaphycus algae extract, 0.15 part of Caesalpinia spinosaKuntze berry extract；
Matrix components are as follows: 1 part of cetostearyl alcohol, 1 part of cocoyl glucoside, 1 part of stearine, PEG-100 are hard 1 part of resin acid ester, 1 part of Sucrose Polystearic Acid Esters, 1 part of Parleam, 1 part of cetanol, 1 part of stearyl alcohol, oleyl alcohol eruciate 2 It is part, 2 parts of isononyl isononanoate, 2 parts of dimethyl silicone polymer, 0.2 part of tocopherol acetate, 0.1 part of carbomer, 5 parts of glycerol, double Third 5 parts of glycol, 3 parts of propylene glycol, 3 parts of beta glucan, 0.1 part of dipotassium glycyrrhizinate and 0.1 part of aminomethyl propanol.
Above-mentioned functional component and matrix components are made to customization eye cream after mixing.
Embodiment 3
Moisture content of skin, skin elasticity R2 value, melanin content MI value and the canthus line area of test subject's second, obtain As a result as follows:
Moisture content of skin: 45.59C.U；Periocualr skin elasticity R2 value: 0.5785；Canthus skin elasticity R2 value: 0.5687；It is black Pigment content MI value: 180.58；Canthus line area: 14.58mm2；
The effect of obtaining formula composition proportion is as follows: 4 parts of ceramide, 6 parts of Xylitol-based glucoside, anhydro xylitol 6 Part, 6 parts of xylitol, 0.5 part of tetrahydro methylpyrimidine carboxylic acid, 4 parts of safflower seed oil, golden 5 parts of button extract, Astragalus membranacus root extract 5 parts of object, 5 parts of ubiquinone, 5 parts of vitamin E, 3 parts of elastin hydrolysis, 2 parts of Wild soybean albumen, dipeptides diaminobutyryl benzyl acyl 2 parts of amine diacetin, 0.3 part of kappaphycus algae extract, 0.3 part of Caesalpinia spinosaKuntze berry extract；
Matrix components are as follows: 1 part of cetostearyl alcohol, 2 parts of cocoyl glucoside, 1 part of stearine, PEG-100 are hard 3 parts of resin acid ester, 1 part of Sucrose Polystearic Acid Esters, 3 parts of Parleam, 1 part of cetanol, 3 parts of stearyl alcohol, oleyl alcohol eruciate 2 It is part, 5 parts of isononyl isononanoate, 2 parts of dimethyl silicone polymer, 1 part of tocopherol acetate, 0.1 part of carbomer, 10 parts of glycerol, double Third 5 parts of glycol, 5 parts of propylene glycol, 3 parts of beta glucan, 0.5 part of dipotassium glycyrrhizinate and 0.1 part of aminomethyl propanol.
Above-mentioned functional component and matrix components are made to customization eye cream after mixing,
Embodiment 4
Moisture content of skin, skin elasticity R2 value, melanin content MI value and the canthus line area of test subject third, obtains As a result as follows:
Moisture content of skin: 35.89C.U；Periocualr skin elasticity R2 value: 0.3582；Canthus skin elasticity R2 value: 0.3416；It is black Pigment content MI value: 170.56；Canthus line area: 28.63mm2；
The effect of obtaining formula composition proportion is as follows: 5 parts of ceramide, 8 parts of Xylitol-based glucoside, anhydro xylitol 8 Part, 8 parts of xylitol, 1 part of tetrahydro methylpyrimidine carboxylic acid, 9 parts of safflower seed oil, golden 9 parts of button extract, Astragalus membranacus root extract 9 parts, CoQ9 part, 9 parts of vitamin E, 5 parts of elastin hydrolysis, 1.5 parts of Wild soybean albumen, dipeptides diaminobutyryl benzyl acyl 5 parts of amine diacetin, 1 part of kappaphycus algae extract and 1 part of Caesalpinia spinosaKuntze berry extract；
Matrix components are as follows: 2 parts of cetostearyl alcohol, 1 part of cocoyl glucoside, 3 parts of stearine, PEG-100 are hard 1 part of resin acid ester, 3 parts of Sucrose Polystearic Acid Esters, 1 part of Parleam, 3 parts of cetanol, 1 part of stearyl alcohol, oleyl alcohol eruciate 5 It is part, 2 parts of isononyl isononanoate, 5 parts of dimethyl silicone polymer, 0.2 part of tocopherol acetate, 0.5 part of carbomer, 5 parts of glycerol, double Third 10 parts of glycol, 3 parts of propylene glycol, 5 parts of beta glucan, 0.1 part of dipotassium glycyrrhizinate and 0.5 part of aminomethyl propanol.
Above-mentioned functional component and matrix components are made to customization eye cream after mixing.
Comparative example 1
This comparative example provides a kind of eye cream, and functional component distribution ratio is as follows: 5 parts of ceramide, Xylitol-based glucoside 10 parts, 10 parts of anhydro xylitol, 10 parts of xylitol, 1 part of tetrahydro methylpyrimidine carboxylic acid, 10 parts of safflower seed oil, golden button extract 10 parts, 10 parts of Astragalus membranacus root extract, Ubidecarenone part, 10 parts of vitamin E, 5 parts of elastin hydrolysis, Wild soybean albumen 5 Part, 5 parts of dipeptides diaminobutyryl benzyl amide diacetin, 2 parts of kappaphycus algae extract and 2 parts of Caesalpinia spinosaKuntze berry extract； Matrix components obtain eye cream after mixing with embodiment 2.
Comparative example 2
This comparative example provides a kind of eye cream, and functional component distribution ratio is as follows: 5 parts of ceramide, Xylitol-based glucoside 10 parts, 10 parts of anhydro xylitol, 10 parts of xylitol, 1 part of tetrahydro methylpyrimidine carboxylic acid, 10 parts of safflower seed oil, golden button extract 10 parts, 10 parts of Astragalus membranacus root extract, Ubidecarenone part, 10 parts of vitamin E, 5 parts of elastin hydrolysis, Wild soybean albumen 5 Part, 5 parts of dipeptides diaminobutyryl benzyl amide diacetin, 2 parts of kappaphycus algae extract and 2 parts of Caesalpinia spinosaKuntze berry extract； Matrix components obtain eye cream after mixing with embodiment 3.
Comparative example 3
This comparative example provides a kind of eye cream, and functional component distribution ratio is as follows: 5 parts of ceramide, Xylitol-based glucoside 10 parts, 10 parts of anhydro xylitol, 10 parts of xylitol, 1 part of tetrahydro methylpyrimidine carboxylic acid, 10 parts of safflower seed oil, golden button extract 10 parts, 10 parts of Astragalus membranacus root extract, Ubidecarenone part, 10 parts of vitamin E, 5 parts of elastin hydrolysis, Wild soybean albumen 5 Part, 5 parts of dipeptides diaminobutyryl benzyl amide diacetin, 2 parts of kappaphycus algae extract and 2 parts of Caesalpinia spinosaKuntze berry extract； Matrix components obtain eye cream after mixing with embodiment 4.
Effect example 8
After subject's first morning and evening clean skin, the eye cream soya bean size of Example 2 and comparative example 1 is applied to eye circumference respectively, real The eye cream for applying example 2 is applied to right eye eye circumference skin, and the eye cream of comparative example 1 is applied to left eye eye circumference skin, is massaged into absorption；It is tested After person's second morning and evening clean skin, the eye cream soya bean size of Example 3 and comparative example 2 is applied to eye circumference respectively, and the eye cream of embodiment 3 applies It smears in right eye eye circumference skin, the eye cream of comparative example 2 is applied to left eye eye circumference skin, is massaged into absorption；Subject's the third morning and evening clean skin Afterwards, the eye cream soya bean size of Example 4 and comparative example 3 is applied to eye circumference respectively, and the eye cream of embodiment 4 is applied to right eye eye circumference Skin, the eye cream of comparative example 3 are applied to left eye eye circumference skin, are massaged into absorption.Test subject's first, second and third is distinguished after 8 weeks Each parameter of eyes periocualr skin, the results are shown in Table 10.
10 subject of table periocualr skin problem parameter statistics after 8 weeks
From above-described embodiment as can be seen that the custom ophthalmic that the method for customizing of eye skin care item provided by the invention is prepared Frost can effectively alleviate the eye problems of subject, can effectively be improved using preparation method provided by the invention tested The water content of person's periocualr skin reduces eye circumference wrinkle, alleviates black eye and improves periocualr skin elasticity.From embodiment 2 and comparison The comparison of example 1, the comparison of embodiment 3 and comparative example 2 and the comparison of embodiment 4 and comparative example 3 can be seen that according to characterization by The parameter of examination person's eye problems matches the effect of obtaining ingredient and the proportion of functional component is better than matching using unified functional component The eye cream just obtained, although and can be seen that the eye cream functional component dosage of comparative example offer compared with embodiment from comparative example 1-3 Used in functional component it is more, but do not obtain better skin effect.From the above, it can be seen that eye provided by the present application The method for customizing of portion's skin care item can be effectively prepared to obtain the eye cream suitable for subject's eye problems.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution The range of scheme.

Claims (10)

1. a kind of method for customizing of eye skin care item characterized by comprising according to the ginseng of the characterization eye problems of customized objects Number matching functional component, is then made the eye skin care item comprising the functional component.
2. the method for customizing of eye skin care item according to claim 1, which is characterized in that the eye problems include skin One or more of water content, skin pigment content, skin elasticity, dermatoglyph degree and skin smoothness.
3. the method for customizing of eye skin care item according to claim 2, which is characterized in that if moisture content of skin≤40C.U, Match A1 group functional component；If 40C.U < moisture content of skin≤60C.U, A2 group functional component is matched；If moisture content of skin > 60C.U matches A3 group functional component；
Preferably, the A1 group functional component, the A2 group functional component and the A3 group functional component independently include One or more of ceramide, Xylitol-based glucoside, anhydro xylitol, xylitol；
Preferably, the A1 group component includes: -5 parts of Cer NP, glucoside 5-6 parts Xylitol-based, dehydration in parts by weight 5-6 parts and xylitol 5-6 parts of xylitol；
Preferably, the A2 group component includes: -3 parts of Cer NS, glucoside 3-5 parts Xylitol-based, dehydration in parts by weight 3-5 parts and xylitol 3-5 parts of xylitol；
Preferably, the A3 group component includes: -2 parts of Cer EOS, glucoside 1-3 parts Xylitol-based, dehydration in parts by weight 1-3 parts and xylitol 1-3 parts of xylitol.
4. the method for customizing of eye skin care item according to claim 2, which is characterized in that characterize skin with skin elasticity R2 value Skin elasticity matches B1 group functional component if value≤0.5 skin elasticity R2；If 0.5 value≤0.7 < skin elasticity R2, B2 group is matched Functional component；If skin elasticity R2 value > 0.7, B3 group functional component is matched；
Preferably, the B1 group functional component, the B2 group functional component and the B3 group functional component independently include Tetrahydro methylpyrimidine carboxylic acid, safflower seed oil, golden button extract, Astragalus membranacus root extract, ubiquinone, vitamin E and hydrolysis bullet One or more of property albumen；
Preferably, the B1 group component include: in parts by weight 0.5-1 parts of tetrahydro methylpyrimidine carboxylic acid, 3-4 parts of safflower seed oil, 3-4 parts of golden button extract, 3-4 parts of Astragalus membranacus root extract, 3-4 parts of ubiquinone, 3-4 parts of vitamin E and elastin hydrolysis 4-5 parts；
Preferably, the B2 group component includes: 0.2-0.5 parts of tetrahydro methylpyrimidine carboxylic acid, safflower seed oil 2-3 in parts by weight Part, golden 2-3 parts of button extract, 2-3 parts of Astragalus membranacus root extract, 2-3 parts of ubiquinone, 2-3 parts of vitamin E and hydrolyzed elastin 2-4 parts of albumen；
Preferably, the B3 group component includes: 0.1-0.2 parts of tetrahydro methylpyrimidine carboxylic acid, safflower seed oil 1-2 in parts by weight Part, golden 1-2 parts of button extract, 1-2 parts of Astragalus membranacus root extract, 1-2 parts of ubiquinone, 1-2 parts of vitamin E and hydrolyzed elastin 1-2 parts of albumen.
5. the method for customizing of eye skin care item according to claim 2, which is characterized in that with dermal melanin content MI value Skin pigment content is characterized, if dermal melanin content MI value > 200, matches C1 group functional component；If dermal melanin content Value≤200 MI match C2 group functional component；
Preferably, the C1 group component in parts by weight include: 3-4 parts of Wild soybean albumen, it is glucoside 1-3 parts Xylitol-based, de- 1-3 parts and xylitol 1-3 parts of water xylitol；
Preferably, the C2 group component in parts by weight include: 1-3 parts of Wild soybean albumen, it is glucoside 1-3 parts Xylitol-based, de- 1-3 parts and xylitol 1-3 parts of water xylitol.
6. the method for customizing of eye skin care item according to claim 2, which is characterized in that characterize skin with canthus line area Texture, if canthus line area is > 20mm2, match D1 group functional component；If 15mm2The canthus < line area≤20mm2, matching D2 group functional component；If canthus line area≤15mm2, match D3 group functional component；
Preferably, the D1 group component includes:, 3-5 parts of dipeptides diaminobutyryl benzyl amide diacetin, grows in parts by weight 0.5-1 parts of heart Kappa algae extract, 0.5-1 parts of Caesalpinia spinosaKuntze berry extract, 3-5 parts of safflower seed oil, golden 3-5 parts of button extract, 3-5 parts of Astragalus membranacus root extract, 3-5 parts of ubiquinone and 3-5 parts of vitamin E；
Preferably, the D2 group component includes: 2-3 parts of dipeptides diaminobutyryl benzyl amide diacetin, length in parts by weight 0.3-0.5 parts of heart Kappa algae extract, 0.3-0.5 parts of Caesalpinia spinosaKuntze berry extract, 2-3 parts of safflower seed oil, golden button extract 2-3 Part, 2-3 parts of Astragalus membranacus root extract, 2-3 parts of ubiquinone and 2-3 parts of vitamin E；
Preferably, the D3 group component includes: 1-2 parts of dipeptides diaminobutyryl benzyl amide diacetin, length in parts by weight 0.1-0.3 parts of heart Kappa algae extract, 0.1-0.3 parts of Caesalpinia spinosaKuntze berry extract, 1-2 parts of safflower seed oil, golden button extract 1-2 Part, 1-2 parts of Astragalus membranacus root extract, 1-2 parts of ubiquinone and 1-2 parts of vitamin E.
7. the method for customizing of eye skin care item according to claim 1 to 6, which is characterized in that by described effect The eye skin care item are made in ingredient after mixing with matrix components；
Preferably, the matrix components include moisturizer, surfactant, thickener, dispersing agent, antioxidant, flavouring agent, moisturizing One or more of agent, anti-allergic agent, pH adjusting agent, filler, carrier and solvent.
8. the method for customizing of eye skin care item according to claim 7, which is characterized in that in parts by weight, the matrix Ingredient includes: 1-2 parts of cetostearyl alcohol, 1-2 parts of cocoyl glucoside, 1-3 parts of stearine, PEG-100 stearate 1-3 parts, 1-3 parts of Sucrose Polystearic Acid Esters, 1-3 parts of Parleam, 1-3 parts of cetanol, 1-3 parts of stearyl alcohol, oleyl alcohol erucic acid 2-5 parts of ester, 2-5 parts of isononyl isononanoate, 2-5 parts of dimethyl silicone polymer, 0.2-1 parts of tocopherol acetate, carbomer 0.1- 0.5 part, 5-10 parts of glycerol, 5-10 parts of dipropylene glycol, 3-5 parts of propylene glycol, 3-5 parts of beta glucan, 0.1-0.5 parts of dipotassium glycyrrhizinate With 0.1-0.5 parts of aminomethyl propanol.
9. the method for customizing of eye skin care item according to claim 1 to 6, which is characterized in that the eye shield Skin product include eye cream, lotion, essence, toner or eye mask.
10. a kind of eye maintenance method, which is characterized in that of any of claims 1-9 described the method includes using The skin care item nursing eye circumference skin that the preparation method of customization eye skin care item is prepared.
CN201811400907.1A 2018-11-22 2018-11-22 The method for customizing of eye skin care item and eye maintenance method Pending CN109223602A (en)

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CN112137949A (en) * 2019-06-27 2020-12-29 东莞圣幸健康科技有限公司 Firming and anti-aging composition, application thereof and firming and anti-aging mask
CN112472637A (en) * 2019-10-09 2021-03-12 广东丸美生物技术股份有限公司 Firming essence containing Kappaphycus alvarezii extract and preparation method thereof
CN112603867A (en) * 2021-01-04 2021-04-06 广东名兰化妆品制造有限公司 Skin membrane repairing essence stock solution and preparation method thereof
CN113786361A (en) * 2021-09-26 2021-12-14 湖北省麦诗特生物科技有限公司 Eye cream composition with pouch removing effect and preparation method thereof
CN113797127A (en) * 2021-08-31 2021-12-17 珀莱雅化妆品股份有限公司 Plant fermentation product with anti-dark eye effect and preparation method thereof
CN114712251A (en) * 2022-03-18 2022-07-08 广东丸美生物技术股份有限公司 Moisturizing and anti-wrinkle eye cream and preparation method thereof
CN114948802A (en) * 2022-04-12 2022-08-30 露乐健康科技股份有限公司 Skin care composition for improving poor skin state of people with sleep deficiency, preparation method thereof and skin care product

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CN109820782A (en) * 2019-03-21 2019-05-31 伯德创研(广州)生物科技有限公司 A kind of microemulsion-type anti-wrinkle essence and preparation method thereof
CN109820782B (en) * 2019-03-21 2021-09-10 伯德创研(广州)生物科技有限公司 Microemulsion type wrinkle-removing essence and preparation method thereof
CN112137949A (en) * 2019-06-27 2020-12-29 东莞圣幸健康科技有限公司 Firming and anti-aging composition, application thereof and firming and anti-aging mask
CN112472637A (en) * 2019-10-09 2021-03-12 广东丸美生物技术股份有限公司 Firming essence containing Kappaphycus alvarezii extract and preparation method thereof
CN112603867A (en) * 2021-01-04 2021-04-06 广东名兰化妆品制造有限公司 Skin membrane repairing essence stock solution and preparation method thereof
CN113797127A (en) * 2021-08-31 2021-12-17 珀莱雅化妆品股份有限公司 Plant fermentation product with anti-dark eye effect and preparation method thereof
CN113797127B (en) * 2021-08-31 2023-03-03 珀莱雅化妆品股份有限公司 Plant fermentation product with black eye resisting effect and preparation method thereof
CN113786361A (en) * 2021-09-26 2021-12-14 湖北省麦诗特生物科技有限公司 Eye cream composition with pouch removing effect and preparation method thereof
CN113786361B (en) * 2021-09-26 2024-01-26 湖北省麦诗特生物科技有限公司 Eye cream composition with pouch removing effect and preparation method thereof
CN114712251A (en) * 2022-03-18 2022-07-08 广东丸美生物技术股份有限公司 Moisturizing and anti-wrinkle eye cream and preparation method thereof
CN114948802A (en) * 2022-04-12 2022-08-30 露乐健康科技股份有限公司 Skin care composition for improving poor skin state of people with sleep deficiency, preparation method thereof and skin care product

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