CN108888561A - A kind of lightening compositions and its cosmetics of preparation - Google Patents
A kind of lightening compositions and its cosmetics of preparation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to cosmetic technical field more particularly to a kind of lightening compositions and its skin-lightening cosmetic of preparation.The present invention compounds the components such as ascorbic acid glucoside, niacinamide, and the composition has the improvement colour of skin, reduces the effect of dermal melanin content.Compared with each component or other comparative examples are used alone, composition provided by the invention is in terms of whitening effect with the raising of conspicuousness.Experiment shows have spot position melanin content to have dropped 8.08% relative to behind cosmetics 28 days that before being not used, composition preparation is provided using the present invention, and has dropped 8.16% without spot position melanin content, and the colour of skin improves significant.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of lightening compositions and its skin-lightening cosmetic of preparation.
Background technique
China as the saying goes " a white screening hundred is ugly " that whitening skin is to pursue lifetime of many Mies from ancient times with Bai Weimei.In recent years
Come, with the continuous improvement of living standards, pale skin increasingly constitutes the target of more and more people's pursuit.
Calm black pigment is almost melanin entirely on skin, in the melanocyte between epidermis and corium
It is generated in melanosome, the melanocyte of generation is spread by osmosis to flanking cell.The color of human skin is not depend on black
Chromatophore quantity, but depend on quantity, size, distribution and the melanocyte degree of melanosome.Cause dermal melanin raw
At the reason of mainly include the environmental factors such as inherent cause, ultraviolet light, exhaust gas, active oxygen；Vivo oxidation and anti-oxidant balance are lost
It adjusts；Endocrine disorder；Dysbiosis；Metabolic disorder；Body trace element content exception etc..
The effect of whitening agent is the oxidation way by inhibiting tyrosinase activity or blocking tyrosine to generate melanin
Diameter, so that reducing melanin production achievees the effect that skin whitening.Skin-whitening agents be exactly act on dermal melanin generate,
In metabolic process, inhibits melanin production and meet the substance of specification.Mercury chloride, mercuric iodixde can interfere amino acids in skin
The normal enzymatic conversion of melanin.Therefore all toxic heavy metal mercury or even some cosmetics also contains in many skin-lightening cosmetics
Arsenic.These substances all have high toxicity.Lead, arsenic, mercury content in cosmetics is exceeded, causes damages spy to human health
It is not the formation for inhibiting reproduction cell, influences the fertility of young man.
In addition, currently on the market there are also much with Chinese herbal medicine be main whitening composition whitening product, contained by whitening
Ingredient mainly includes：Arbutin, quinhydrones, vitamin C, kojic acid, azelaic acid, Porcine HGF etc..But these products or only
Can be effective to certain color spots, it is invalid to freckle if arbutin can only be effective to chloasma.Or there is stimulation and damage to skin
Evil, such as the cosmetics containing quinhydrones are easier to cause systemic toxicity, as kojic acid is easy to cause contact skin when additive amount is larger
It is scorching.Therefore, the hot spot that safely and effectively whitening product is still people's research is found.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is that providing the whitening of a kind of lightening compositions and its preparation
Cosmetics.The lightening compositions can be effectively reduced melanin content, improve skin shine, improve coloration, while can mention
High keratoderma moisture content, and there is good safety.
Lightening compositions provided by the invention are grouped as by the group of following mass parts：
In the embodiment of the present invention, the lightening compositions are grouped as by the group of following mass parts：
In some specific embodiments, the lightening compositions are grouped as by the group of following mass parts：
In some specific embodiments, the lightening compositions are grouped as by the group of following mass parts：
In some specific embodiments, the lightening compositions are grouped as by the group of following mass parts：
The extractive composition is grouped as by following group：Mushroom extract liquor, safflower extract, Gotu Kola P.E, tiger
Cane root extract, radix scutellariae root extract, tea extract, german chamomile flower extract, rosemary leaf extract, glycyrrhiza glabra root mention
Take object, Artemisia capillaris flower extract, mulberry root extract and jujube berry extract composition.
In the extractive composition, the mass ratio of each component is：Mushroom extract liquor, safflower extract, centella are extracted
Object, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary
Leaf extract, Artemisia capillaris flower extract, mulberry root extract and jujube berry extract=(0.5~1.5)：(0.001~0.003)：
(0.05-0.3)：(0.05-0.3)：(0.05-0.3)： (0.05-0.2)：(0.1-1)：(0.1-0.3)：(0.1-0.3)：
(0.03-0.2)：(0.02-0.3)：(0.05-0.5).
In the extractive composition, the mass ratio of each component is：Mushroom extract liquor, safflower extract, centella are extracted
Object, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary
Leaf extract, Artemisia capillaris flower extract, mulberry root extract and jujube berry extract=0.5：0.001：0.05：0.05：0.05：
0.05：0.6：0.1：0.1：0.03：0.02： 0.05.
In the extractive composition, the mass ratio of each component is：Mushroom extract liquor, safflower extract, centella are extracted
Object, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary
Leaf extract, Artemisia capillaris flower extract, mulberry root extract and jujube berry extract=1：0.002：0.2：0.2：0.2：0.1：0.8：
0.1：0.1：0.2：0.2：0.1.
In the extractive composition, the mass ratio of each component is：Mushroom extract liquor, safflower extract, centella are extracted
Object, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary
Leaf extract, Artemisia capillaris flower extract, mulberry root extract and jujube berry extract=1.5：0.003：0.3：0.3：0.3：0.2：1：
0.3：0.3：0.2：0.3：0.5.
The present invention compounds the components such as butanediol, ascorbic acid glucoside, extractive composition, niacinamide, is formed
Composition can be significantly reduced the melanin content in skin, improve the colour of skin.The effect is compared with being used alone each component
Or compared using traditional lightening compositions, all with the raising of conspicuousness.Illustrate under proportion appropriate, each component compounding
Synergistic effect is produced, to improve the effect of whitening.In extractive composition, each component close fit is indispensable.
Also, experiment shows that composition provided by the invention can also improve keratoderma moisture content, and has good peace
Quan Xing.Through detecting, after providing cosmetics made from composition using the present invention, the dermal melanin content of subject significantly drops
Low, skin coloration L* value and ITA ° of value have apparent ascendant trend (P<0.001), b* value and a* value have certain decline to become
Gesture；And using after test product, the skin splash color of subject and the visual score of size all have apparent downward trend
(P<0.05), the colour of skin, which improves degree scoring, has the trend (P significantly risen<0.05), show that the present invention provides composition system
Standby cosmetics can have the effect of good lightening the stain and improve the colour of skin.
Lightening compositions provided by the invention are preparing the application in cosmetics.
The present invention also provides a kind of cosmetics, lightening compositions of the present invention.
In cosmetics provided by the invention the mass fraction of lightening compositions provided by the invention be 9.75%~
26.09%.
Further include in cosmetics provided by the invention：Water, thickener, pH adjusting agent, solubilizer, preservative, buffer,
Chelating agent and essence.
In the present invention, the thickener is xanthan gum and Ka Bo U-20；
The pH adjusting agent is arginine；
The solubilizer is PEG-60 rilanit special；
The preservative is methylparaben；
The buffer is sodium citrate and citric acid；
The chelating agent is EDETATE SODIUM.
In the embodiment of the present invention, the essence is made of orchid essence and aloe flavour, and the mass ratio of the two is 3~6.
In some embodiments, cosmetics provided by the invention are grouped as by the group of following mass fraction：
In some embodiments, cosmetics provided by the invention are grouped as by the group of following mass fraction：
In some embodiments, cosmetics provided by the invention are grouped as by the group of following mass fraction：
Cosmetics provided by the invention are facial mask.
Said components are present in the facial mask liquid of facial mask, and cosmetics further include mask matrix.
In the present invention, the mask matrix uses non-woven fabrics.
The present invention compounds the components such as butanediol, ascorbic acid glucoside, hyaluronic acid, niacinamide, the composition
With the colour of skin is improved, the effect of dermal melanin content is reduced.Compared with each component or other comparative examples are used alone, this hair
The composition of bright offer is in terms of whitening effect with the raising of conspicuousness.Experiment shows to use relative to before being not used
After the present invention provides cosmetics 28 days of composition preparation, there is spot position melanin content to have dropped 8.08%, and without spot position
Melanin content has dropped 8.16%, and the colour of skin improves significant.
Specific embodiment
The present invention provides a kind of lightening compositions and its skin-lightening cosmetics of preparation., those skilled in the art can borrow
Reflect present disclosure, is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to ability
It is it will be apparent that they are considered as being included in the present invention for field technique personnel.Method and application of the invention has been led to
Preferred embodiment is crossed to be described, related personnel obviously can not depart from the content of present invention, in spirit and scope to this paper's
Methods and applications are modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
The test material that the present invention uses is all common commercially available product, can all be bought in market.
In the extractive composition, the main component of mushroom extract liquor is polysaccharide；The main component of safflower extract is
Safflower flavone；The main component of Gotu Kola P.E is Asiaticoside；The main component of polygonum cuspidate root extract be resveratrol and
Rheum emodin；The main component of radix scutellariae root extract is baicalin；The main component of tea extract is tea polyphenols；Flos Chrysanthemi mentions
The main component for taking object is chrysanthemum flavones；The main component of rosemary leaf extract is Rosmarinic acid；Glycyrrhiza glabra root extract
Main component be that glycyrrhiza glabra plain (Glabrene) and glycyrrhiza glabra are determined；The main component of Artemisia capillaris flower extract is Cas
No：223747-93-1；The main component of mulberry root extract is flavones and polysaccharide；The main component of jujube berry extract is jujube soap
Glucoside I, II, III, jujuboside B.
Below with reference to embodiment, the present invention is further explained：
Examples 1 to 3
The mass fraction of each component such as table 1 in prescription：
1 Examples 1 to 3 prescription of table
Above-mentioned each component is mixed, through homogenizing facial mask liquid after stirring.
It after facial mask liquid is dispensed, is mixed with mask matrix, packs and facial mask is made.
Comparative example 1~2
The mass fraction of each component such as table 2 in prescription：
2 comparative example of table, 1~2 prescription
Above-mentioned each component is mixed, through homogenizing facial mask liquid after stirring.
It after facial mask liquid is dispensed, is mixed with mask matrix, packs and facial mask is made.
Effect assessment
1 subject's screening criteria
1.1 inclusion criteria
1.1.1. Health China women, the age was between 20~45 years old；
1.1.2. without severe chronic deeline (asthma, diabetes etc.)；
1.1.3. without skin injury, inflammation, eczema etc.；
1.1.4. bilateral cheek has dry skin and the colour of skin is obscure (tarnish)；
1.1.5. facial area has obvious color spot person；
1.1.6. subject does not participate in other clinical tests, and is ready to cooperate sun-proof measure during test；
1.1.7. subject according to test requirements document and can sign informed consent form.
1.2 exclusion criteria
1. being currently in pregnancy period, nursing period or the women in the pregnancy of next two monthly plans；
2. recipient site has the diseases such as dermatitis, scar or serious epifolliculitis, and may be to the test result person of impacting；
Receive antiallergic sense injection treatment 3. having, and last time injection is will to receive in past 8 days or during research
Such treatment；
4. having oral hormone class drug in nearly one month or using antihistaminic immune formulation person in nearly one week；
5. nearest 1 year progress laser beautifying, electric wave draw the nursing of the medical and beauty treatments such as skin or shaping cosmetic surgery person；
6. research starts the previous moon, subject begins to use the cosmetics with whitening effect；
7. once having done change within past two weeks to the cosmetics that recipient site uses or having changed the habit of skin care；
8. being included in the research same day in recipient site skin uses cosmetics or drug；
9. cannot as required, on time return visit person or be reluctant sign informed consent form person.
1.3 exit standard
During test, there is adverse reaction, lost to follow-up without reason or violate research approach (such as using other to grinding in subject
Study carefully the influential cosmetics of result or drug) and the case where other cause specifics, responsible person assesses confirmation after study, if
The subject has been no longer appropriate for the case where continuing this test, may require that the subject exits.
2 subjects
By as above screening, totally 150 female subjects are selected, are randomly divided into 5 groups, respectively experimental group and control group,
Experimental group 1~3 successively gives the facial mask of Examples 1 to 3 respectively；Control group 1~2 successively gives the face of comparative example 1~2 respectively
Film
3 test materials
3.1 test product
The facial mask of Examples 1 to 3 passes through normal individual trial progress whitening effect evaluation in 28 days.
Subject's normal skin nursing mildy wash used, moisturizer or suncream are all the same.
3.2 product application method and frequency
Test group：
Morning:Face cleaning → moisturizer → suncream (only use on daytime)
At night:Face cleaning → Examples 1 to 3 facial mask → moisturizer
Control group：
Morning:Face cleaning → moisturizer → suncream (only use on daytime)
At night:Facial mask → moisturizer of face cleaning → comparative example 1~2
(* subject is in and voluntarily uses, and spreads on face once a day)
3.3 environmental condition
22 DEG C ± 2 DEG C of temperature, relative humidity 55% ± 5%
3.4 test methods and result
3 evaluation method serial number of table
Data analysis uses SPSS21.0 statistical software.Using duplicate measurements variance analysis and Generalized estimating equation to each
The baseline value (D0) of a parameter and return visit numerical value (D3, D7, D14, D21 and D28) carry out difference analysis.Significance,statistical
Difference uses p<0.05*,p<0.01**,p<0.001*** mark.
3.4.1 safetyandsideeffect is evaluated
During test, adverse reaction observation and assessment have carried out seven times altogether, be respectively in D0, D3, D7, D14, D21 and
It is paid a return visit when D28.It is dry, oily to inquire whether subject face occurs during using test product by professional skin section doctor
The symptoms such as greasy, furfur, rubescent, shouting pain, and observe and record whether face has the phenomenon that fash, redness and furfur.Then according to table
1 standards of grading score, and score charges to case report form, and the being associated property of standard according to listed by table 4 is assessed.
The standards of grading of 4 adverse reaction of table score
The assessment of 5 test product of table is scored
By test in 28 days, adverse reaction occurs during test without subject, illustrates that the embodiment of the present invention is made
Facial mask safety it is higher.
3.4.2 the analysis of keratoderma water content
Keratoderma moisture content is measured by Corneometer；Its numerical value is bigger, then keratoderma moisture content
Higher, i.e. the replenishing water and preserving moisture effect of product is better.
After using test product, the testing result of cheek skin moisture content is as follows：
6 keratoderma moisture content change (A.U.) of table
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | 36.72±12.62 | 38.20±13.54 | 38.35±12.97 | 37.23±9.17 |
| D3 | 38.72±13.61 | 41.59±15.25 | 41.87±13.66 | 41.52±10.61 |
| D7 | 40.62±14.05 | 46.24±13.62 | 46.71±14.21 | 40.66±9.49 |
| D14 | 40.79±13.87 | 42.79±14.99 | 45.53±12.37 | 43.37±9.35 |
| D21 | 42.33±15.01 | 45.06±15.70 | 45.90±13.52 | -- |
| D28 | 43.33±14.22 | 46.52±13.05 | 46.78±14.38 | -- |
Test group 1：Compared with baseline value (D0), the moisture content point of skin when D3, D7, D14, D21 and D28 are paid a return visit
5.45%, 10.62%, 11.08%, 15.28% and 18.00% is not risen.Analysis of variance, in D3, D7, D14, D21 and
When D28 is paid a return visit there is apparent significant difference (P in the moisture content of cheek area skin compared with D0<0.05).
Test group 2：Compared with baseline value (D0), the moisture content point of skin when D3, D7, D14, D21 and D28 are paid a return visit
8.88%, 21.06%, 12.03%, 17.97% and 21.79% is not risen.Analysis of variance, in D3, D7, D14, D21 and
When D28 is paid a return visit there is apparent significant difference (P in the moisture content of cheek area skin compared with D0<0.05).
Test group 3：Compared with baseline value (D0), the moisture content point of skin when D3, D7, D14, D21 and D28 are paid a return visit
9.18%, 21.80%, 18.72%, 19.69% and 21.98% is not risen.Analysis of variance, in D3, D7, D14, D21 and
When D28 is paid a return visit there is apparent significant difference (P in the moisture content of cheek area skin compared with D0<0.05).
Control group 1：Compared with baseline value (D0), when D3, D7 and D14 are paid a return visit, the moisture content of skin rises respectively
11.53%, 9.23% and 16.50%.Analysis of variance, the moisture content of cheek area skin when D3, D7 and D14 are paid a return visit
There are significant difference (P compared with D0<0.05).The test result of control group 2 similarly, present by the moisture content of skin
The trend of liter, moisture content after 14 days before use compared with there is also significant difference (P<0.05).
Analysis of variance discovery, the moisture of skin when D7 is paid a return visit, between each test group (1~3)-control group (1~2) group
Changes of contents has apparent significant difference (P<0.01)；And wherein the skin moisture content of test group 3 is raised the most aobvious
It writes, there is also significant difference, (P compared with test group 1 or test group 2 for the effect<0.01).
3.4.3 skin shine is analyzed
The glossiness of skin of face is measured by Skin Glossmeter, and the numerical value the high, shows that skin is more glossy.
After using test product, the testing result of skin shine is as follows：
The difference analysis of 7 skin shine of table
Test group 1：Compared with baseline value (D0), the glossiness difference of skin when D3, D7, D14, D21 and D28 are paid a return visit
Rise 3.62%, 5.61%, 7.44%, 7.69% and 8.09%.Analysis of variance, in each cheek skin for paying a return visit time point
There is apparent significant difference (P compared with D0 in the glossiness of skin<0.001).
Test group 2：Compared with baseline value (D0), the glossiness difference of skin when D3, D7, D14, D21 and D28 are paid a return visit
Rise 5.43%, 8.28%, 10.36%, 10.85% and 11.61%.Analysis of variance, in each cheek for paying a return visit time point
There is apparent significant difference (P compared with D0 in the glossiness of skin<0.001).
Test group 3：Compared with baseline value (D0), the glossiness difference of skin when D3, D7, D14, D21 and D28 are paid a return visit
Rise 6.09%, 10.00%, 12.87%, 13.68% and 14.82%.Analysis of variance, in each face for paying a return visit time point
There is apparent significant difference (P compared with D0 in the glossiness of cheek skin<0.001).
Control group 1：Compared with baseline value (D0), when D3, D7 and D14 are paid a return visit, the glossiness of skin rises respectively
2.40%, 3.01% and 2.39%.Analysis of variance, when D3 and D7 is paid a return visit, the skin shine at cheek position is compared with D0
There are significant difference (P<0.01).Similarly, the glossiness of skin is in rising trend for the test result of control group 2, and 14 days
Glossiness afterwards before use compared with there is also significant difference (P<0.05).
Analysis of variance discovery, when D3, D7 and D14 are paid a return visit, the glossiness of the skin between test group-control group group becomes
Changing has apparent significant difference (P<0.05)；And wherein the skin shine of test group 3 is raised the most significant, the effect
There is also significant difference, (P compared with test group 1 or test group 2 for fruit<0.01).
3.4.4 the analysis of dermal melanin content
The content of melanin is to determine an important factor of human body skin complexion, the more high then skin of melanin content
The colour of skin is more obscure.The melanin of skin of face is measured by Mexameter MX18, and numerical value is bigger, then melanin content is higher.
3.4.4.1 the analysis of target color spot position melanin content
After using test product, the melanin content testing result of facial target color spot area skin is as follows：
The difference analysis of 8 target color spot position melanin content of table
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | 221.38±30.21 | 229.19±31.38 | 220.56±30.67 | 222.32±31.61 |
| D3 | 217.97±32.03 | 223.25±3.95 | 213.81±31.44 | 221.08±33.01 |
| D7 | 216.99±31.33 | 221.69±32.55 | 211.16±31.28 | 220.10±30.98 |
| D14 | 213.98±31.14 | 217.38±31.50 | 205.28±30.72 | 218.34±30.44 |
| D21 | 213.60±30.08 | 216.31±31.27 | 202.94±32.08 | -- |
| D28 | 210.63±31.07 | 210.66±32.14 | 199.23±32.12 | -- |
Test group 1：Compared with baseline value (D0), the melanin content of target color spot area skin in D3, D7, D14, D21 and
D28 has dropped 1.54%, 1.98%, 3.34%, 3.51% and 4.86% when paying a return visit respectively.Analysis of variance discovery, with D0 phase
Than each target color spot area skin melanin content for paying a return visit time point shows apparent significant difference (P < 0.001).
Test group 2：Compared with baseline value (D0), the melanin content of target color spot area skin in D3, D7, D14, D21 and
D28 has dropped 2.59%, 3.27%, 5.15%, 5.62% and 8.08% when paying a return visit respectively.Analysis of variance discovery, with D0 phase
Than each target color spot area skin melanin content for paying a return visit time point shows apparent significant difference (P < 0.001).
Test group 3：Compared with baseline value (D0), the melanin content of target color spot area skin in D3, D7, D14, D21 and
D28 has dropped 3.06%, 4.26%, 6.93%, 7.99% and 9.67% when paying a return visit respectively.Analysis of variance discovery, with D0 phase
Than each target color spot area skin melanin content for paying a return visit time point shows apparent significant difference (P < 0.001).
Control group 1：Compared with baseline value (D0), when D3, D7 and D14 are paid a return visit, dermal melanin content has dropped respectively
0.56%, 1.00% and 1.79%.Analysis of variance, the dermal melanin content and D0 at cheek position when D3 and D7 is paid a return visit
Compared to there is no significant differences.Similarly, melanin content has certain decline to the test result of control group 2, and does not make
With before, significant difference is not present in the content after the 7th day compared with D0.
Analysis of variance discovery, wherein the dermal melanin content decline of test group 3 is the most significant, the effect and examination
Group 1~2 or control group 1~2 are tested compared to there is also significant difference, (P<0.01).
3.4.4.2 the analysis without spot control position melanin content
After using test product, melanin content testing result of the face without spot control area skin is as follows：
Difference analysis of the table 9 without color spot position melanin content
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | 170.98±20.88 | 175.84±22.69 | 170.45±21.97 | 169.98±20.08 |
| D3 | 169.07±21.22 | 171.72±22.30 | 165.44±20.76 | 168.88±21.79 |
| D7 | 168.09±20.91 | 169.41±22.65 | 162.31±21.78 | 168.32±21.86 |
| D14 | 167.01±21.35 | 166.78±21.45 | 158.88±20.69 | 167.51±21.47 |
| D21 | 166.48±21.38 | 165.03±21.89 | 156.85±21.08 | |
| D28 | 165.47±20.76 | 161.50±21.47 | 154.85±22.05 |
Test group 1：Compared with baseline value (D0), the melanin content of no spot control area skin is in D3, D7, D14, D21
1.12%, 1.69%, 2.32%, 2.63% and 3.22% is had dropped respectively when paying a return visit with D28.Analysis of variance discovery, with D0
It compares, each return visit time point shows apparent significant difference (P < without spot control position dermal melanin content
0.001)。
Test group 2：Compared with baseline value (D0), the melanin content of no spot control area skin is in D3, D7, D14, D21
2.34%, 3.66%, 5.15%, 6.15% and 8.16% is had dropped respectively when paying a return visit with D28.Analysis of variance discovery, with D0
It compares, each return visit time point shows apparent significant difference (P < without spot control position dermal melanin content
0.001)。
Test group 3：Compared with baseline value (D0), the melanin content of no spot control area skin is in D3, D7, D14, D21
2.94%, 4.79%, 6.79%, 7.98% and 9.15% is had dropped respectively when paying a return visit with D28.Analysis of variance discovery, with D0
It compares, each return visit time point shows apparent significant difference (P < without spot control position dermal melanin content
0.001)。
Control group：Compared with baseline value (D0), when D3, D7 and D14 are paid a return visit, dermal melanin content has dropped respectively
0.65%, 0.98% and 1.45%.Analysis of variance, the dermal melanin content and D0 at cheek position when D3 and D7 is paid a return visit
Compared to there is no significant differences.Similarly, melanin content has certain decline to the test result of control group 2, and does not make
With before, significant difference is not present in the content after the 7th day compared with D0.
And wherein the dermal melanin content of test group 3 declines the most significant, the effect and test group 1 or test group 2
Compared to there is also significant difference, (P<0.01).
3.4.5 the analysis of skin coloration
Blee chromatic value L*, a* and b* value is detected to obtain by Chromameter CM-2600D instrument, the evaluation of L* value
The brightness of skin complexion, and a* and b* then respectively indicate the partially red and partially yellow degree of skin, ITA ° is known as coloration angle, indicates skin
The fairness of skin is calculated by L*, b* value；L* value is bigger or a* and b* value is smaller, then is more healthy skin complexion.
Then the bigger expression colour of skin of numerical value is more pale for ITA ° obtained by L*, b*.
3.4.5.1 the analysis of target color spot position coloration
After using test product, L*, b*, ITA ° of facial target color spot position, a* value testing result are as follows：
The difference analysis of 10 target color spot position coloration of table
Test group 1：Compared with baseline value (D0), target color spot position L* value pays a return visit the time-division in D3, D7, D14, D21 and D28
0.65%, 0.91%, 1.12%, 1.88% and 2.38% is not risen.B* value rises respectively when D3, D7 and D14 are paid a return visit
0.94%, 1.29% and 1.93%, and 0.59% and 1.04% are had dropped respectively when D21 and D28 is paid a return visit.ITA ° value D3,
D7, D14, D21 and D28 rise 4.13%, 5.93%, 6.51%, 11.39% and 14.64% when paying a return visit respectively.A* value exists
D3, D7, D14, D21 and D28 have dropped 2.10%, 2.51%, 3.21%, 5.31% and 5.61% when paying a return visit respectively.Classical prescription
Difference analysis discovery, L*, b*, ITA ° for respectively paying a return visit the target color spot position at time point compared with D0 or a* value show conspicuousness
Difference (P < 0.05).
Test group 2：Compared with baseline value (D0), target color spot position L* value is distinguished when D3, D7, D14, D21 and D28 are paid a return visit
Rise 0.91%, 1.28%, 1.60%, 2.18% and 2.71%.B* value rises respectively when D3 and D14 is paid a return visit
0.88%, 0.38% and 1.70%, and 0.17% and 2.20% are had dropped respectively when D21 and D28 is paid a return visit.ITA ° value D3,
D7, D14, D21 and D28 rise 7.79%, 12.10%, 13.56%, 20.86% and 27.29% when paying a return visit respectively.A* value
4.15%, 4.91%, 6.06%, 9.06% and 8.48% is had dropped respectively when D3, D7, D14, D21 and D28 are paid a return visit.Through
Variance analysis discovery, L*, b*, ITA ° for respectively paying a return visit the target color spot position at time point compared with D0 or a* value are shown significantly
Sex differernce (P < 0.05).
Test group 3：Compared with baseline value (D0), target color spot position L* value pays a return visit the time-division in D3, D7, D14, D21 and D28
1.08%, 1.51%, 2.03%, 2.33% and 2.93% is not risen.B* value rises respectively when D3, D7 and D14 are paid a return visit
0.21%, 0.11% and 0.05%, and 1.48% and 2.64% are had dropped respectively when D21 and D28 is paid a return visit.ITA ° value D3,
D7, D14, D21 and D28 rise 8.29%, 13.26%, 15.04%, 24.04% and 28.83% when paying a return visit respectively.A* value
5.02%, 6.11%, 7.88%, 9.85% and 10.05% is had dropped respectively when D3, D7, D14, D21 and D28 are paid a return visit.Through
Variance analysis discovery, L*, b*, ITA ° for respectively paying a return visit the target color spot position at time point compared with D0 or a* value are shown significantly
Sex differernce (P < 0.05).
Control group 1：Compared with baseline value (D0), target color spot position L* value pays a return visit the time-division in D3, D7, D14, D21 and D28
0.13%, 0.14%, 0.31%, 1.45% and 1.78% is not risen.B* value rises respectively when D3, D7 and D14 are paid a return visit
1.05%, 1.58% and 2.21%, and 0.21% and 0.79% are had dropped respectively when D21 and D28 is paid a return visit.ITA ° value D3,
D7, D14, D21 and D28 rise 1.76%, 3.00%, 3.65%, 4.23% and 7.52% when paying a return visit respectively.A* value D3,
D7, D14, D21 and D28 have dropped 1.07%, 1.17%, 1.46%, 2.63% and 2.73% when paying a return visit respectively.Classical prescription difference
Analysis discovery, compared with D0, it is poor that L*, b*, ITA ° of each target color spot position for paying a return visit time point or a* value do not show conspicuousness
Different (P > 0.05).The test result of control group 2 similarly, compared with baseline value, using rear D3, D7, D14, D21 and D28,
L*, b*, ITA ° of target color spot position, a* do not show significant difference (P > 0.05).
Analysis of variance discovery, when D3, D7, D14, D21 and D28 are paid a return visit, coloration between test group-control group group
Variation has apparent significant difference (P<0.05)；And wherein the skin coloration of test group 3 improves the most significant, the effect
There is also significant difference, (P compared with test group 1 or test group 2 for fruit<0.01).
3.4.5.2 the analysis without color spot position coloration
After using test product, L*, b*, ITA ° of facial target color spot position, a* value testing result are as follows：
Difference analysis of the table 11 without color spot position coloration
Test group 1：Compared with baseline value (D0), no color spot position L* value pays a return visit the time-division in D3, D7, D14, D21 and D28
0.36%, 0.58%, 0.95%, 1.04% and 1.12% is not risen.B* value rises respectively when D3, D7 and D14 are paid a return visit
2.39%, 2.74%, 3.27% and 3.33%, and 0.18% is had dropped when D28 is paid a return visit.ITA ° of value is in D3, D7, D14, D21
1.65%, 3.33%, 3.39%, 5.21% and 7.52% is risen respectively when paying a return visit with D28.A* value is in D3, D7, D14, D21
4.3%, 4.83%, 7.09%, 7.2% and 7.2% is had dropped respectively when paying a return visit with D28.Analysis of variance discovery, with D0 phase
Than each L*, b*, ITA without color spot position ° for paying a return visit time point or a* value show significant difference (P < 0.05).
Test group 2：Compared with baseline value (D0), no color spot position L* value pays a return visit the time-division in D3, D7, D14, D21 and D28
0.95%, 1.31%, 1.86%, 1.98% and 2.11% is not risen.B* value D3, D7, D14 and D21 pay a return visit when respectively on
2.20%, 2.50%, 2.99% and 1.04% has been risen, and has had dropped 0.43% when D28 return visit.ITA ° value D3, D7, D14,
D21 and D28 rises 2.19%, 3.45%, 5.00%, 6.96% and 8.53% when paying a return visit respectively.A* value D3, D7, D14,
D21 and D28 has dropped 6.37%, 7.90%, 11.34%, 11.34% and 10.44% when paying a return visit respectively.Analysis of variance hair
Existing, compared with D0, each L*, b*, ITA without color spot position ° for paying a return visit time point or a* value show significant difference (P <
0.05)。
Test group 3：Compared with baseline value (D0), no color spot position L* value pays a return visit the time-division in D3, D7, D14, D21 and D28
1.26%, 1.8%, 2.34%, 2.61% and 2.79% is not risen.B* value rises respectively when D3, D7 and D14 are paid a return visit
0.76%, 0.82% and 1.01%, and 0.70% and 0.76% are had dropped respectively when D21 and D28 is paid a return visit.ITA ° value D3,
D7, D14, D21 and D28 rise 2.43%, 5.04%, 5.70%, 7.83% and 9.65% when paying a return visit respectively.A* value D3,
D7, D14, D21 and D28 have dropped 7.51%, 9.76%, 13.64%, 14.89% and 15.52% when paying a return visit respectively.Classical prescription
Difference analysis discovery, compared with D0, each L*, b*, ITA without color spot position ° for paying a return visit time point or a* value show conspicuousness
Difference (P < 0.05).
Control group 1：Compared with baseline value (D0), no color spot position L* value has dropped respectively when D3, D7 and D14 are paid a return visit
0.31%, 0.49% and 0.37%.B* value has dropped 0.41% and 0.53% when D3 and D7 is paid a return visit respectively, and when D14 return visit
Rise 0.60%.ITA ° of value has dropped 1.00%, 1.88% and 2.20% when D3, D7 and D14 are paid a return visit respectively.A* value exists
Value rises 1.07%, 1.34% and 0.80% when D3, D7 and D14 are paid a return visit respectively.Analysis of variance discovery, compared with D0,
Each L*, b*, ITA without color spot position ° for paying a return visit time point or a* value do not show significant difference (P > 0.05).It is right
According to group 2 test result similarly, compared with baseline value, using rear D3, D7, D14, D21 and D28, no color spot position
L*, b*, ITA °, a* do not show significant difference (P > 0.05).
Analysis of variance discovery, when D3, D7, D14, D21 and D28 are paid a return visit, coloration between test group-control group group
Variation has apparent significant difference (P<0.05)；And wherein the skin coloration of test group 3 improves the most significant, the effect
There is also significant difference, (P compared with test group 1 or test group 2 for fruit<0.01).
3.4.6 the analysis of clinical visual score
Using before and after test product, degree is improved by color spot of the qualified dermatologist to subject's face and is carried out
Visual score.
Skin of face situation clinical assessment is by dermatologist's foundation《SKIN AGING ATLAS 2： ASIAN TYPE》
" Density of pigmentary spots's " in (R.Bazin&F.Flament, 2010 editions, MED ' COM publishing house)
0-7 grades, the 0-5 grade of " Contrast of isolated pigmentary of the face " and " Size of an
The standard diagram of the 0-7 grade of isolated spot " is evaluated, and the score value of this visual score is widely applied to clinic and comments
In estimating.
3.4.6.1 facial colour spot density analysis
Unilateral facial area is chosen by professional skin section doctor to visually assess.Score value is lower, indicates the color spot of facial area
Density is lower, product to lighten the stain effect better, after test product, the scoring of experimental group 2 and baseline value (D0)
' 3.66 ' compare, and facial colour spot density does not change when D3, D7, D14, D21 and D28 are paid a return visit, i.e. scoring mean value is
‘3.66'.Analysis of variance discovery does not show conspicuousness in each color spot density scores for paying a return visit time point compared with D0
Difference (P>0.05) effect of experimental group 1 and experimental group 3 is similarly.
3.4.6.2 facial target color spot color, size analysis
Professional skin section doctor chooses unilateral face and visually assesses.Score value is lower, indicates the target color spot color of face
Lighter, the effect that product lightens the stain is better.Unilateral face is visually assessed, score value is lower, indicates the target color spot of face
It is smaller, product to lighten the stain effect better：After test product, the visual score of the facial target color spot color of subject
As a result as follows：
The analysis of 12 facial colour spot of table
Test group 1：Compared with the scoring ' 2.39 ' of baseline value (D0), facial target color spot color score is paid a return visit in D3 to be risen
To ' 2.40 ', and ' 2.35,2.24,2.18,2.04 ' are fallen to respectively when D7, D14, D21 and D28 are paid a return visit.In terms of size,
Compared with the scoring ' 3.17 ' of baseline value (D0), the scoring of facial target color spot size does not change when D3 is paid a return visit, D7,
D14, D21 and D28 fall to ' 3.15,3.11,2.93,2.91 ' when paying a return visit respectively.Analysis of variance discovery, compared with D0,
Target color spot color score and size scoring all have significant difference (P when D14, D21 and D28 are paid a return visit<0.05).
Test group 2：Compared with the scoring ' 2.47 ' of baseline value (D0), facial target color spot color score is paid a return visit in D3 to be risen
To ' 2.50 ', and ' 2.41,2.19,2.09 and 1.88 ' are fallen to respectively when D7, D14, D21 and D28 are paid a return visit.In terms of size,
Compared with the scoring ' 3.28 ' of baseline value (D0), the scoring of facial target color spot size does not change when D3 is paid a return visit, D7,
D14, D21 and D28 fall to ' 3.25,3.13,2.88 and 2.78 ' when paying a return visit respectively.Analysis of variance discovery, compared with D0,
When D14, D21 and D28 are paid a return visit, target color spot color score and size scoring all have significant difference (P<0.05).
Test group 3：Compared with the scoring ' 2.45 ' of baseline value (D0), facial target color spot color score is paid a return visit in D3 to be risen
To ' 2.46 ', and ' 2.27,1.86,1.74,1.46 ' are fallen to respectively when D7, D14, D21 and D28 are paid a return visit.In terms of size,
Compared with the scoring ' 3.27 ' of baseline value (D0), the scoring of facial target color spot size does not change when D3 is paid a return visit, D7,
D14, D21 and D28 fall to ' 3.23,3.02,2.71,2.53 ' when paying a return visit respectively.Analysis of variance discovery, compared with D0,
Target color spot color score and size scoring all have significant difference (P when D14, D21 and D28 are paid a return visit<0.05).
Control group 1：Compared with the scoring ' 2.37 ' of baseline value (D0), facial target color spot color score is paid a return visit in D3 to be risen
To ' 2.38 ', and ' 2.37,2.37,2.35,2.33 ' are fallen to respectively when D7, D14, D21 and D28 are paid a return visit.In terms of size,
Compared with the scoring ' 3.16 ' of baseline value (D0), the scoring of facial target color spot size does not change when D3 is paid a return visit, D7,
D14, D21 and D28 fall to ' 3.15,3.14,3.10,3.09 ' when paying a return visit respectively.Analysis of variance discovery, compared with D0,
Target color spot color score and size scoring do not have significant difference (P > 0.05) when D14, D21 and D28 are paid a return visit.Control group 2
Testing result similarly, compared with D0, D14, D21 and D28 pay a return visit when target color spot color score and size scoring does not have
There is significant difference (P > 0.05).
Analysis of variance discovery, the color spot face when D3, D7, D14, D21 and D28 are paid a return visit, between test group-control group group
The variation of color has apparent significant difference (P<0.05)；And wherein the scoring of test group 3 reduces the most significant, the effect
There is also significant difference, (P compared with test group 1 or test group 2 for fruit<0.01).
3.4.6.3 blee improves the analysis of degree scoring
Using before and after product, degree is improved by color spot of the qualified dermatologist to subject's face and carries out vision
Scoring, standards of grading are as shown in table 13：
13. blee of table improves the reference standard rank of degree scoring
| Reference standard | |
| 0 grade | There is no any improvement |
| 1 grade | It is slight to improve |
| 2 grades | Moderate improves |
| 3 grades | It is obviously improved |
After test product, the visual score result that the blee of subject improves degree is as follows：
14 blee of table improves the analysis of degree scoring
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | -- | |||
| D3 | 0.15±0.41 | 0.16±0.37 | 0.24±0.39 | 0.13±0.40 |
| D7 | 0.30±0.38 | 0.34±0.48 | 0.49±0.42 | 0.21±0.42 |
| D14 | 0.48±0.39 | 0.63±0.49 | 0.91±0.38 | 0.29±0.38 |
| D21 | 0.50±0.42 | 0.66±0.48 | 1.02±0.44 | 0.32±0.37 |
| D28 | 0.60±0.43 | 0.81±0.40 | 1.35±0.41 | 0.36±0.40 |
Test group 1：The colour of skin improve degree D3, D7, D14, D21 and D28 pay a return visit when scoring be 0.15,0.30,
0.48,0.50,0.60'.Analysis of variance discovery, compared with D3, when D7, D14, D21 and D28 are paid a return visit, the colour of skin improves degree
Scoring shows significant difference (P<0.05).
Test group 2：The colour of skin improve degree D3, D7, D14, D21 and D28 pay a return visit when scoring be ' 0.16,0.34,
0.63,0.66 and 0.81 '.Analysis of variance discovery, compared with D3, when D7, D14, D21 and D28 are paid a return visit, the colour of skin improves degree
Scoring shows significant difference (P<0.05).
Test group 3：The colour of skin improve degree D3, D7, D14, D21 and D28 pay a return visit when scoring be 0.24,0.49,
0.91,1.02,1.35'.Analysis of variance discovery, compared with D3, when D7, D14, D21 and D28 are paid a return visit, the colour of skin improves degree
Scoring shows significant difference (P<0.05).
Control group 1：The colour of skin improve degree D3, D7, D14, D21 and D28 pay a return visit when scoring be 0.13,0.21,
0.29,0.32,0.36'.Analysis of variance discovery, compared with D3, when D7, D14, D21 and D28 are paid a return visit, the colour of skin improves degree
Scoring does not show significant difference (P > 0.05).Similarly, Analysis of variance is found, with D3 phase for the scoring of control group 2
Than when D7, D14, D21 and D28 are paid a return visit, colour of skin improvement degree scoring does not show significant difference (P > 0.05).
Analysis of variance discovery, when D7, D14, D21 and D28 are paid a return visit, color spot color between test group-control group group
Variation has apparent significant difference (P<0.05)；And wherein the scoring of test group 3 reduce it is the most significant, the effect with
Test group 1 or test group 2 are compared to there is also significant difference, (P<0.01).
3.4.7 subject's self-appraisal questionnaire analysis
Each subject completes when D7, D14 and D28 are paid a return visit using the self-evaluation questionnaire after product.It is required that subject
According to the subjective feeling after test product is used, test product is evaluated.Score combines itself impression to refer to by subject
Standards of grading carry out.As a result scoring takes 0-9 points of systems (wherein：The using effect of the very dissatisfied test product of 0-, 9- is very
It is satisfied with the using effect of test product).According to standards of grading, each subject is after using test product, to the matter of test product
The features such as ground and effect include product moistness, improve dermatoglyph, improve skin gloss, lighten the stain with bright color etc.
Aspect is evaluated.
After product using embodiment 2 while paying a return visit (D7), subject more than 84% for product feature such as smell,
The satisfaction with higher such as quality and texture, and have more than the absorption and property easy to use of 93% subject for product
It is satisfied with.No less than 78% subject is satisfied with for the nourishes rough skin of product, fine skin texture and other effects；Extremely
Rare 75% subject think product can even skin tone, so that skin is become pale glossy；Subject more than 62% recognizes
The problems such as capable of lightening the stain color for product, reduce color spot quantity, skin pockmark, spot can be made reduction.
Use nourishes rough skin, exquisiteness of the subject for product after 2 product of embodiment (when D28 is paid a return visit), more than 84%
Dermatoglyph and other effects is satisfied with；And at least 84% subject think product can even skin tone, so that skin is become white
It is fair-skinned glossy；Subject more than 78% think product can lighten the stain color, reduce color spot quantity, can make skin pockmark,
The problems such as spot, is reduced.Having more than 96% subject indicates to be satisfied with for the overall efficacy of product；Have at least 93%
Subject is ready to buy this test product in the case where not considering product price.
This effect can not be obtained using the product of embodiment 1 or embodiment 3, satisfaction is poor, and only carries out daily nursing
Control group subject indicate have no that the colour of skin has clear improvement.
3.5 conclusion
The whitening mask & moisturizer & suncream that 28 days are provided by the embodiment of the present invention 2 is used continuously by subject
Clinical white-skinned face function test, the results showed that：
1. the keratoderma moisture content of subject has apparent ascendant trend (P using after test product<0.05),
Show that test product has effects that replenishing water and preserving moisture and nourishes rough skin.
2. the skin shine of subject has the tendency that obviously rising (P using after test product<0.01)；Compared to control
Group, the whitening mask of test group have effects that preferably to promote skin gloss.
3. the dermal melanin content of subject has apparent downward trend (P using after test product<0.001),
Show that the whitening mask of test group has the effect of whitening skin lightening.
4. the skin coloration L* value of subject and ITA ° of value have apparent ascendant trend (P using after test product<
0.001), b* value and a* value have certain downward trend；Compared to the control group, the whitening mask of test group, which has, preferably improves
Skin coloration, the effect for promoting whitening skin degree.
5. using after test product, the skin splash color of subject and the visual score of size all have it is apparent under
Drop trend (P<0.05), the colour of skin, which improves degree scoring, has the trend (P significantly risen<0.05), show the whitening of test group
Facial mask has the effect of good lightening the stain and improve the colour of skin.
6. whitening mask has certain skin care, improves texture, highlights skin from the point of view of the result of subject's self-appraisal
Color, skin whitening and other effects.
7. tested products have preferable safety.
The above is only the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications should also regard
For protection scope of the present invention.
Claims (10)
1. a kind of lightening compositions, which is characterized in that be grouped as by the group of following mass parts：
2. lightening compositions according to claim 1, which is characterized in that be grouped as by the group of following mass parts：
3. lightening compositions according to claim 1 or 2, which is characterized in that the extractive composition is by following component
Composition：Mushroom extract liquor, safflower extract, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea extract,
German chamomile flower extract, rosemary leaf extract, glycyrrhiza glabra root extract, Artemisia capillaris flower extract, mulberry root extract and jujube fruit
Extract composition.
4. the described in any item lightening compositions of claims 1 to 3 are preparing the application in cosmetics.
5. a kind of cosmetics, which is characterized in that including the described in any item lightening compositions of claims 1 to 3.
6. cosmetics according to claim 5, which is characterized in that the wherein described in any item whitening groups of claims 1 to 3
The mass fraction for closing object is 9.75%~26.09%.
7. cosmetics according to claim 5, which is characterized in that wherein further include：Water, thickener, pH adjusting agent, solubilising
Agent, preservative, buffer, chelating agent and essence；
The thickener is xanthan gum and Ka Bo U-20；
The pH adjusting agent is arginine；
The solubilizer is PEG-60 rilanit special；
The preservative is methylparaben；
The buffer is sodium citrate and citric acid；
The chelating agent is EDETATE SODIUM.
8. the cosmetics according to claim 6 or 6, which is characterized in that
9. cosmetics according to claim 8, which is characterized in that be grouped as by the group of following mass fraction：
10. according to the described in any item cosmetics of claim 5~9, which is characterized in that it is facial mask.
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| CN114712260A (en) * | 2022-04-07 | 2022-07-08 | 上海新高姿化妆品有限公司 | Skin external composition with effects of relieving, repairing and whitening skin |
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