CN108852939A - A kind of moisture-keeping composition and its cosmetics of preparation - Google Patents
A kind of moisture-keeping composition and its cosmetics of preparation Download PDFInfo
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- CN108852939A CN108852939A CN201810965824.0A CN201810965824A CN108852939A CN 108852939 A CN108852939 A CN 108852939A CN 201810965824 A CN201810965824 A CN 201810965824A CN 108852939 A CN108852939 A CN 108852939A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to cosmetic technical field more particularly to a kind of moisture-keeping composition and its moisturizing cosmetics of preparation.Composition provided by the invention is compounded by components such as butanediol, glycine betaine, glycerol, Sodium Hyaluronates, and the composition, which has, improves skin moisture content, reduces the lost effect of moisture of skin.Compared with each component or other comparative examples are used alone, composition provided by the invention is in terms of moistening effect with the raising of conspicuousness.Experiment shows that skin TEWL value reduces by 14.36% relative to behind cosmetics 7 days that before being not used, composition preparation is provided using the present invention；And cuticula moisture content is improved up to 59.78% after using 7 days.
Description
Technical field
The present invention relates to cosmetic technical field more particularly to a kind of moisture-keeping composition and its moisturizing cosmetics of preparation.
Background technique
Skin is the main protective film of human body, is consisted of three parts, by being followed successively by epidermis inward outside, corium and subcutaneous group
It knits.Wherein, epidermis is divided into four layers, i.e. basal cell layer, stratum spinosum epidermidis, granular cell layer and cuticula.Studies have shown that skin contains
Water number be the key that skin it is tender, plentiful, glossy with it is soft whether, and have dry skin true cause be in cuticula
Water deficient.
On the one hand with age, skin moisture-keeping mechanism is damaged, and skin tissue cell and intercellular moisture contain
Amount is reduced, and when cuticula moisture drops to 10% or less, skin, which will seem, dries, follows the string, wrinkles and accelerate skin
Skin aging.Another aspect skin is encroached on by sweltering heat, cold, wind, detergent and ultraviolet radiation etc., and surface layer can become more
It is dry.Therefore the moisture of skin how is kept, it is particularly significant to reduce moisture loss.
Currently, common cosmetic humectant mainly has：Natural moisturizing factor, amino acids, polyalcohols and macromolecule
Biochemical class, still, moisturizing class cosmetics available on the market are although many kinds of, but there are still moistening effect is unobvious and moisturizing
Time is short, the unabiding problem of moisturizing.Therefore, the hot spot that safely and effectively skin moisturizer is still research is further found.
Summary of the invention
In view of this, the technical problem to be solved in the present invention is that providing the moisturizing of a kind of moisture-keeping composition and its preparation
Cosmetic, rationally, moistening effect is significant and good security for the composition formula.
Moisture-keeping composition provided by the invention is grouped as by the group of following mass parts：
In the embodiment of the present invention, the moisture-keeping composition is grouped as by the group of following mass parts：
In some specific embodiments, the moisture-keeping composition is grouped as by the group of following mass parts：
In some specific embodiments, the moisture-keeping composition is grouped as by the group of following mass parts：
In some specific embodiments, the moisture-keeping composition is grouped as by the group of following mass parts：
The extractive composition by dried tremella extract, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract,
Tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, Watermelon Fruit extract, Apples
Real extract, Lens culinaris berry extract, heartsease extract and Radix Ophiopogonis root extract composition.
In the extractive composition, the mass ratio of each component is：Dried tremella extract, Gotu Kola P.E, polygoni cuspidati,radix mention
Take object, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, west
Melon fruit extract, Apple extract, Lens culinaris berry extract, heartsease extract and Radix Ophiopogonis root extract=(1~3)：
(0.1-0.3)：(0.1-0.3)：(0.1-0.3)：(0.05-0.1)：(0.1-0.6)：(0.05-0.2)：(0.05-0.2)：
(0.1-0.5)：(0.1-0.5)：(0.1-0.5)：(0.5~1.5)：(0.5~1.5).
In the extractive composition, the mass ratio of each component is：Dried tremella extract, Gotu Kola P.E, polygoni cuspidati,radix mention
Take object, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, west
Melon fruit extract, Apple extract, Lens culinaris berry extract, heartsease extract and Radix Ophiopogonis root extract=1：0.1：
0.1：0.1：0.05：0.2：0.05：0.05：0.1：0.1：0.1：0.5：0.5.
In the extractive composition, the mass ratio of each component is：Dried tremella extract, Gotu Kola P.E, polygoni cuspidati,radix mention
Take object, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, west
Melon fruit extract, Apple extract, Lens culinaris berry extract, heartsease extract and Radix Ophiopogonis root extract=2：0.2：
0.2：0.2：0.1：0.4：0.1：0.1：0.3：0.3：0.4：1：1.
In the extractive composition, the mass ratio of each component is：Dried tremella extract, Gotu Kola P.E, polygoni cuspidati,radix mention
Take object, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, west
Melon fruit extract, Apple extract, Lens culinaris berry extract, heartsease extract and Radix Ophiopogonis root extract=3：0.3：
0.3：0.3：0.1：0.6：0.2：0.2：0.5：0.5：0.5：1.5：1.5.
The present invention compounds the components such as butanediol, glycine betaine, glycerol, extractive composition, the composition energy of formation
Enough significant raising skin moisture contents, reduce moisture of skin and scatter and disappear.The effect compared with each component is used alone or using pass
The moisture-keeping composition of system is compared, all with the raising of conspicuousness.Illustrate under proportion appropriate, each component compounding produces synergy
Effect, to improve moistening effect.In extractive composition, each component close fit is indispensable.Through detecting, this is used
After invention provides cosmetics made from composition, the skin TEWL value of subject is significantly reduced, and keratoderma moisture content
It significantly rises, moreover the skin shine of subject is also obviously improved.It is investigated according to sense organ, subject thinks this hair
The bright cosmetics for providing composition preparation can have moisturizing, moisten, improve dermatoglyph, glossy effect, and have good
Safety.
Moisture-keeping composition provided by the invention is preparing the application in cosmetics.
The present invention also provides a kind of cosmetics comprising moisture-keeping composition of the present invention.
In cosmetics provided by the invention the mass fraction of moisture-keeping composition provided by the invention be 14.14%~
30.08%.
Further include in cosmetics provided by the invention：Water, thickener, pH adjusting agent, solubilizer, preservative, buffer, chela
Mixture and essence.
In some embodiments, cosmetics provided by the invention are grouped as by the group of following mass fraction：
In cosmetics provided by the invention, the thickener is xanthan gum and Ka Bo U-20；The pH adjusting agent is smart ammonia
Acid；The solubilizer is PEG-60 rilanit special；The preservative is methylparaben；The buffer be sodium citrate and
Citric acid；The chelating agent is EDETATE SODIUM；The essence is essence NJ239954.
In some embodiments, cosmetics provided by the invention are grouped as by the group of following mass fraction：
In some embodiments, cosmetics provided by the invention are grouped as by the group of following mass fraction：
Cosmetics provided by the invention are facial mask.
Said components are present in the facial mask liquid of facial mask, and cosmetics further include mask matrix.
In the present invention, the mask matrix uses non-woven fabrics.
Composition provided by the invention is compounded by components such as butanediol, glycine betaine, glycerol, extractive compositions, should
Composition, which has, improves skin moisture content, reduces the lost effect of moisture of skin.With exclusive use each component or other comparisons
Example is compared, and composition provided by the invention is in terms of moistening effect with the raising of conspicuousness.Experiment shows relative to unused
Before, behind cosmetics 7 days that composition preparation is provided using the present invention, skin TEWL value reduces by 14.36%；And after using 7 days
Cuticula moisture content is improved up to 59.78%.
Specific embodiment
The present invention provides a kind of moisture-keeping composition and its moisturizing cosmetic of preparation, those skilled in the art can be used for reference
Present disclosure is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to this field skill
It is it will be apparent that they are considered as being included in the present invention for art personnel.Method of the invention and application by compared with
Good embodiment is described, related personnel obviously can not depart from the content of present invention, in spirit and scope to methods herein
It is modified or appropriate changes and combinations with application, carrys out implementation and application the technology of the present invention.
The test material that the present invention uses is all common commercially available product, can all be bought in market.
In the extractive composition, the main component of dried tremella extract is tremella polysaccharides；Gotu Kola P.E it is main
Ingredient is Asiaticoside；The main component of polygonum cuspidate root extract is resveratrol and rheum emodin；Radix scutellariae root extract it is main at
It is divided into baicalin；The main component of tea extract is tea polyphenols；The main component of glycyrrhiza glabra root extract is glycyrrhiza glabra
Plain (Glabrene) and glycyrrhiza glabra are fixed；The main component of german chamomile flower extract is chrysanthemum flavones；The master of rosemary leaf extract
Wanting ingredient is Rosmarinic acid；The main component of Watermelon Fruit extract is citrulling；The main component of Apple extract is
Apple polyphenol；The main component of Lens culinaris berry extract is cas 90063-40-4；The main component of heartsease extract is three colors
Violet Huang glucoside；The main component of Radix Ophiopogonis root extract is ophiopogon saponin.
Below with reference to embodiment, the present invention is further explained：
Examples 1 to 3
The mass fraction of each component such as table 1 in prescription：
1 Examples 1 to 3 prescription of table
Above-mentioned each component is mixed, through homogenizing facial mask liquid after stirring.
It after facial mask liquid is dispensed, is mixed with mask matrix, packs and facial mask is made.
Comparative example 1~3
The mass fraction of each component such as table 2 in prescription：
2 comparative example of table, 1~3 prescription
| Comparative example 1 | Comparative example 2 | |
| 1,3 butylene glycol | 9.24% | 6.06% |
| Glycerin polyether -26 | 3.96% | 1.52% |
| Glycerol | 2.64% | 1.52% |
| Oat beta glucan | 1.32% | 1.52% |
| Glycine betaine | 1.32% | 1.14% |
| Parahydroxyacet-ophenone | 0.40% | 0.30% |
| 1,2- hexylene glycol | 0.40% | 0.30% |
| Trehalose | 0.66% | 1.14% |
| Hydroxylated lecithin | 0.66% | 1.14% |
| Oat peptide | 1.32% | 1.14% |
| Extractive composition | 7.92% | 6.82% |
| Allantoin | 0.07% | 0.04% |
| Sodium Hyaluronate | 0.08% | 0.08% |
| Dipotassium glycyrrhizinate | 0.04% | 0.02% |
| D-pantothenyl aleohol | 0.08% | 0.08% |
| Xanthan gum | 0.10% | 0.10% |
| Card wave U-20 | 0.10% | 0.10% |
| Arginine | 0.12% | 0.12% |
| PEG-60 rilanit special | 0.06% | 0.06% |
| Methylparaben | 0.05% | 0.05% |
| Sodium citrate | 0.03% | 0.03% |
| Citric acid | 0.02% | 0.02% |
| EDETATE SODIUM | 0.02% | 0.02% |
| Essence NJ239954 | 0.01% | 0.01% |
| Water | 69.41% | 76.69% |
Above-mentioned each component is mixed, through homogenizing facial mask liquid after stirring.
It after facial mask liquid is dispensed, is mixed with mask matrix, packs and facial mask is made.
Effect assessment
1 subject's screening criteria
1.1 inclusion criteria
1.1.1. Health China women, the age was between 20~50 years old；
1.1.2. without severe chronic deeline (asthma, diabetes etc.)；
1.1.3. without skin injury, inflammation, eczema etc.；
1.1.4. cheek moisture of skin is lower than 45a.u.；
1.1.5. subject does not participate in other clinical tests, and is ready to cooperate sun-proof measure during test；
1.1.6. subject according to test requirements document and can sign informed consent form；
1.2 exclusion criteria
1.2.1. pregnancy period, nursing period or the women in the pregnancy of next two monthly plans are currently in；
1.2.2. recipient site has the diseases such as dermatitis, scar or serious epifolliculitis, and may impact to test result
Person；
1.2.3. have and receive antiallergic sense injection treatment, and last time injection is in the past in 8 days or will be during research
Receive such treatment；
1.2.4. within past two weeks, change once has been done to the cosmetics that recipient site uses or has changed the habit of skin care
It is used；
1.2.5. being included in the research same day in recipient site skin uses cosmetics or drug；
1.2.6. research starts the previous moon, and subject begins to use the cosmetics with moistening effect.10.3 exiting mark
It is quasi-
1.3 exit standard
During test, there is adverse reaction, lost to follow-up without reason or violation research approach (as used other to research in subject
As a result influential cosmetics or drug) and it the case where other cause specifics, assesses and confirms by dermatologist, if should be by
Examination person has been no longer appropriate for the case where continuing this test, may require that the subject exits.
2 subjects
By as above screening, totally 150 female subjects are selected, are randomly divided into 5 groups, respectively experimental group and control group,
Experimental group 1~3 successively gives the facial mask of Examples 1 to 3 respectively；Control group 1~2 successively gives the face of comparative example 1~2 respectively
Film.
3 test materials
3.1 test product
The facial mask of Examples 1 to 3 passes through normal individual trial progress anti-aging effects evaluation in 28 days.
Subject's normal skin nursing mildy wash used, moisturizer or suncream are all the same.
3.2 product application methods and frequency
Test group：
Morning:Face cleaning → moisturizer → suncream (only use on daytime)
At night:Face cleaning → Examples 1 to 3 facial mask → moisturizer
Control group：
Morning:Face cleaning → moisturizer → suncream (only use on daytime)
At night:Facial mask → moisturizer of face cleaning → comparative example 1~2
(* subject is in and voluntarily uses, and spreads on face once a day)
3.3 environmental condition
22 ± 1 DEG C of temperature, relative humidity 50 ± 3%
3.4 test methods and result
3 evaluation method serial number of table
Data analysis uses SPSS21.0 statistical software.Using duplicate measurements variance analysis and Generalized estimating equation to each
The baseline value (D0) of parameter and return visit numerical value (D0T30min, D0T2h, D0T4h, D0T8h and D3, D7) carry out difference analysis.
Statistical significant difference uses p<0.05*,p<0.01**,p<0.001*** mark.
3.4.1 safetyandsideeffect is evaluated
During test, adverse reaction observation and assessment carried out altogether seven times, be respectively D0, D0T30min, D0T2h,
It is paid a return visit when D0T4h, D0T8h and D3, D7.Inquire whether subject is gone out during using test product by professional skin section doctor
The symptoms such as existing facial dry, greasy, furfur, rubescent, shouting pain, and observe and record whether face has showing for fash, redness and furfur
As.It is then scored according to the standards of grading of table 2, score charges to case report form, and the standard according to listed by table 3 is closed
The assessment of connection property.
The standards of grading of 4 adverse reaction of table score
The assessment of 5 test product of table is scored
By test in 28 days, adverse reaction occurs during test without subject, illustrates that the embodiment of the present invention is made
Facial mask safety it is higher.
3.4.2 the analysis of skin transepidermal water loss rate (TEWL)
Skin transepidermal water loss rate (Trans-epidermal waterloss, TEWL) is measured by Tewameter, is reflection
The important parameter of skin barrier function.Measured numerical value is lower, then the barrier function of skin and repair ability are better.
After using test product, the testing result of cheek area skin TEWL value is as follows：
6 cheek skin TEWL value (g/hm of table2)
| Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 | |
| D0 | 16.41±2.46 | 16.51±2.73 | 15.42±2.27 | 15.95±2.99 |
| D3 | 15.09±2.27 | 14.65±2.57 | 13.01±2.19 | 17.21±4.13 |
| D7 | 14.98±2.36 | 14.14±2.25 | 12.59±2.41 | 17.25±4.12 |
As the result is shown：
Experimental group 1：Compared with a reference value (D0), when D3 and D7 is paid a return visit, skin TEWL value has respectively reduced 8.04% He
8.71%.Analysis of variance, when D3 and D7 is paid a return visit, there are apparent conspicuousnesses compared with D0 for the skin TEWL value at cheek position
Difference (P<0.01).
Experimental group 2：Compared with a reference value (D0), when D3 and D7 is paid a return visit, skin TEWL value has respectively reduced 11.27% He
14.35%.Analysis of variance, when D3 and D7 is paid a return visit, there are apparent conspicuousnesses compared with D0 for the skin TEWL value at cheek position
Difference (P<0.001).
Experimental group 3：Compared with a reference value (D0), when D3 and D7 is paid a return visit, skin TEWL value has respectively reduced 15.63% He
18.35%.Analysis of variance, when D3 and D7 is paid a return visit, there are apparent conspicuousnesses compared with D0 for the skin TEWL value at cheek position
Difference (P<0.01).
Control group 1：Compared with a reference value (D0), when D3 and D7 is paid a return visit, skin TEWL value rises 7.91% He respectively
8.13%.Analysis of variance, when D7 is paid a return visit, there are significant difference (P compared with D0 for the skin TEWL value at cheek position<
0.05).Similarly, the TEWL value of skin is in rising trend for the test result of control group 2, the TEWL and D0 when paying a return visit for D7 days
Compared to there is also significant difference (P<0.05).
Analysis of variance discovery, when D3 and D7 is paid a return visit, the skin TEWL variation between test group 1~3 and control group group is all
With significant difference (P<0.001)；And wherein the TEWL of test group 3 lowers the most significant, the effect and test group 1 or examination
Group 2 is tested compared to there is also significant difference, (P<0.01).
3.4.3 keratoderma moisture content analysis
Keratoderma moisture content is measured by Corneometer；Its numerical value is bigger, then keratoderma moisture content is got over
The moisturizing effect of height, i.e. product is better.
3.4.3.1 the analysis (eight hours moistening effects) of cheek skin moisture content
After using test product, the testing result of cheek skin moisture content (moisturizing in eight hours) is as follows：
7 keratoderma moisture content change (A.U.) of table (moisturizing in eight hours)
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | 19.67±9.25 | 19.88±8.93 | 20.13±8.88 | 19.58±10.02 |
| The rear 30min of D0 | 29.89±8.89 | 34.67±10.43 | 37.90±9.74 | 22.43±9.57 |
| The rear 2h of D0 | 25.43±10.36 | 27.79±9.70 | 29.86±10.32 | 21.65±8.88 |
| The rear 4h of D0 | 24.87±8.91 | 26.10±8.34 | 28.67±9.06 | 20.23±9.07 |
| The rear 8h of D0 | 21.96±10.25 | 24.07±8.38 | 27.01±8.62 | 20.38±10.13 |
Test group 1：Compared with a reference value (D0), the moisture of skin when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
Content rises 51.96%, 29.28%, 26.44% and 11.64% respectively.Analysis of variance, the cheek skin in each return visit
Moisture content there is significant difference (P compared with D0<0.001).
Test group 2：Compared with a reference value (D0), the moisture of skin when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
Content rises 74.40%, 39.79%, 31.29% and 21.08% respectively.Analysis of variance, the cheek skin in each return visit
Moisture content there is significant difference (P compared with D0<0.001).
Test group 3：Compared with a reference value (D0), the moisture of skin when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
Content rises 88.28%, 48.34%, 42.42% and 34.18% respectively.Analysis of variance, the cheek skin in each return visit
Moisture content there is significant difference (P compared with D0<0.001).Control group 1：Compared with a reference value (D0),
Skin moisture content rises 14.56%, 10.57%, 3.32% respectively when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
With 4.08%.Analysis of variance, in each return visit there is significant difference (P in the moisture content of cheek skin compared with D0<
0.01).Similarly, the moisture content of skin is in rising trend for the test result of control group 2, moisture content and use after 8h
It is preceding compared to there is also significant difference (P<0.05).
Analysis of variance discovery, in return visit in the 2nd~8 hour, the skin between test group 1~3 and 1~2 group of control group contained
Water all has significant difference (P<0.001)；And wherein the moisture content of skin of test group 3 improves the most significant, the effect
There is also significant difference, (P compared with test group 1 or test group 2<0.01).
3.4.3.2 the analysis of cheek skin moisture content
After using test product, the testing result of cheek skin moisture content is as follows：
8 keratoderma moisture content change (A.U.) of table
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | 20.06±9.09 | 19.88±8.93 | 20.75±9.41 | 20.90±9.05 |
| D3 | 27.62±9.78 | 28.53±10.02 | 30.58±10.00 | 23.07±10.92 |
| D7 | 29.88±8.93 | 31.77±9.66 | 33.62±8.79 | 22.96±9.86 |
Test group 1：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the moisture content of skin rises respectively
37.69% and 48.95%.Analysis of variance, when D3 and D7 is paid a return visit, the moisture content of cheek area skin exists compared with D0
Apparent significant difference (P<0.001).
Test group 2：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the moisture content of skin rises respectively
43.51% and 59.81%.Analysis of variance, when D3 and D7 is paid a return visit, the moisture content of cheek area skin exists compared with D0
Apparent significant difference (P<0.001).
Test group 3：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the moisture content of skin rises respectively
47.37% and 62.02%.Analysis of variance, when D3 and D7 is paid a return visit, the moisture content of cheek area skin exists compared with D0
Apparent significant difference (P<0.001).
Control group 1：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the moisture content of skin rises respectively
10.38% and 9.86%.Analysis of variance, when D3 and D7 is paid a return visit, the moisture content of cheek area skin exists aobvious compared with D0
Write sex differernce (P<0.05).Similarly, the moisture content of skin is in rising trend for the test result of control group 2, D7 days water
Point content before use compared with there is also significant difference (P<0.05).
Analysis of variance finds that the skin moisture content variation between test group (1~3)-control group (1~2) group has bright
Aobvious significant difference (P<0.001)；And wherein the skin moisture content of test group 3 is raised the most significant, the effect and examination
It tests group 1~2 or control group 1~2 is compared and all there is significant difference, (P<0.01).
3.4.4 the analysis of skin shine
The glossiness of skin of face is measured by Skin Glossmeter, and the numerical value the high, shows that skin is more glossy.
3.4.4.1 the analysis (eight hours lightening effects) of cheek skin shine
After using test product, the testing result of cheek skin shine (eight hours glossy) is as follows：
9 skin shine of table changes (g/m2h)
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | 54.76±12.76 | 56.63±10.31 | 54.98±11.74 | 55.90±12.05 |
| The rear 30min of D0 | 68.51±16.90 | 77.40±18.83 | 78.11±15.80 | 59.79±15.34 |
| The rear 2h of D0 | 61.69±15.71 | 67.98±14.14 | 66.96±12.67 | 59.21±12.99 |
| The rear 4h of D0 | 59.33±15.56 | 63.66±12.79 | 63.03±10.65 | 57.22±11.43 |
| The rear 8h of D0 | 57.09±12.73 | 61.16±12.53 | 61.88±12.07 | 56.98±12.36 |
Test group 1：Compared with a reference value (D0), the light of skin when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
Damp degree rises 25.11%, 12.66%, 8.35% and 4.25% respectively.Analysis of variance, the cheek skin in each return visit
Glossiness has the tendency that obviously rising, and compared with D0, shows apparent significant difference, p<0.001.
Test group 2：Compared with a reference value (D0), the light of skin when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
Damp degree rises 36.68%, 20.05%, 12.42% and 8.01% respectively.Analysis of variance, the cheek skin in each return visit
Glossiness has the tendency that obviously rising, and compared with D0, shows apparent significant difference, p<0.001.
Test group 3：Compared with a reference value (D0), the light of skin when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
Damp degree rises 42.07%, 21.79%, 14.64% and 12.55% respectively.Analysis of variance, the cheek skin in each return visit
Glossiness have the tendency that obviously rising, and compared with D0, show apparent significant difference, p<0.001.
Control group 1：Compared with a reference value (D0), the light of skin when D0T30min, D0T2h, D0T4h and D0T8h are paid a return visit
Damp degree rises 6.96%, 5.92%, 2.36% and 1.93% respectively.Analysis of variance, the light of cheek skin in each return visit
Damp degree has the tendency that obviously rising, and compared with D0, shows apparent significant difference, p<0.01.The test knot of control group 2
Similarly, the glossiness of skin is in rising trend for fruit, the glossiness after 8h before use compared with there is also significant difference (P<
0.05)。
Analysis of variance finds that the skin shine variation between test group (1~3)-control group (1~2) group has obvious
Significant difference (P<0.001)；And wherein the skin shine of test group 3 is raised the most significant, the effect and test group 1
~2 or control group 1~2 compared to all there is significant difference, (P<0.01).
3.4.4.2 the analysis of cheek skin shine
After using test product, the testing result of cheek skin shine is as follows：
10 skin shine of table changes (g/m2h)
| Time | Experimental group 1 | Experimental group 2 | Experimental group 3 | Control group 1 |
| D0 | 52.69±11.07 | 56.63±10.31 | 55.78±11.30 | 54.38±11.46 |
| D3 | 56.96±9.88 | 62.23±9.21 | 62.82±10.23 | 55.71±10.47 |
| D7 | 60.08±10.86 | 66.06±8.75 | 66.85±8.97 | 56.12±10.93 |
Test group 1：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the glossiness of skin rises 8.10% He respectively
14.03%.Analysis of variance, when D3 and D7 is paid a return visit, there are apparent conspicuousnesses compared with D0 for the skin shine at cheek position
Difference (P<0.001).
Test group 2：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the glossiness of skin rises 9.89% He respectively
16.65%.Analysis of variance, when D3 and D7 is paid a return visit, there are apparent conspicuousnesses compared with D0 for the skin shine at cheek position
Difference (P<0.001).
Test group 3：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the glossiness of skin rises 12.62% respectively
With 19.84%.Analysis of variance, when D3 and D7 is paid a return visit, the skin shine at cheek position exists apparent significant compared with D0
Sex differernce (P<0.001).
Control group 1：Compared with a reference value (D0), when D3 and D7 is paid a return visit, the glossiness of skin rises 2.44% He respectively
3.20%.Analysis of variance, when D3 and D7 is paid a return visit, cheek position obtains skin shine and significant difference is not present compared with D0
(P > 0.05).Similarly, the glossiness of skin is in rising trend for the test result of control group 2, the glossiness after 7 days with make
With preceding compared to also there is no significant difference (P > 0.05).
Analysis of variance finds that the glossiness variation of the skin between test group-control group group has apparent conspicuousness poor
Different (P<0.001).And wherein the skin shine of test group 3 is raised the most significant, the effect and test group 1 or test group 2
Compared to there is also significant difference, (P<0.05).
3.4.5 subject's self-appraisal questionnaire analysis
Each subject completes when D0, D3 and D7 are paid a return visit using the self-evaluation questionnaire after product.It is required that subject's root
According to the subjective feeling after test product is used, test product is evaluated.Score combines itself impression reference to comment by subject
Minute mark standard carries out.As a result scoring takes 1-9 points of systems (wherein：The using effect of the very dissatisfied test product of 1-, 9- are very satisfied
The using effect of test product).According to standards of grading, 31 subjects are after using test product, the effect of to test product
It is evaluated including product moisturizing, improvement dermatoglyph and skin gloss etc..
The result shows that using after the product of embodiment 2 after 7 days (D7), whole subjects for product water profit, nourish,
Moistening effect indicates very satisfied；It is tight caused by dry skin that about 97% subject thinks that the facial mask of embodiment 2 can improve
Impression；And the effect for having more than 96% subject and capable of improving dermatoglyph and skin glow for the product indicates full
Meaning；Most subjects (more than 93%) can allow face to seem that full, healthy effect is satisfied with product.But make
In subject with 3 facial mask of embodiment 1 or embodiment, only 72%, 78% think satisfied respectively.
The above is only the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of moisture-keeping composition, which is characterized in that be grouped as by the group of following mass parts：
2. moisture-keeping composition according to claim 1, which is characterized in that be grouped as by the group of following mass parts：
3. moisture-keeping composition according to claim 1 or 2, which is characterized in that the extractive composition is extracted by tremella
Object, Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, Flos Chrysanthemi
Extract, rosemary leaf extract, Watermelon Fruit extract, Apple extract, Lens culinaris berry extract, heartsease extract
It is formed with Radix Ophiopogonis root extract.
4. the described in any item moisture-keeping compositions of claims 1 to 3 are preparing the application in cosmetics.
5. a kind of cosmetics, which is characterized in that including the described in any item moisture-keeping compositions of claims 1 to 3.
6. cosmetics according to claim 5, which is characterized in that the wherein described in any item moisturizing groups of claims 1 to 3
The mass fraction for closing object is 14.14%~30.08%.
7. cosmetics according to claim 5, which is characterized in that wherein further include：Water, thickener, pH adjusting agent, solubilising
Agent, preservative, buffer, chelating agent and essence.
8. cosmetics according to claim 7, which is characterized in that be grouped as by the group of following mass fraction：
The described in any item moisture-keeping compositions 14.14%~30.08% of claims 1 to 3；
9. cosmetics according to claim 7 or 8, which is characterized in that
The thickener is xanthan gum and Ka Bo U-20；
The pH adjusting agent is arginine；
The solubilizer is PEG-60 rilanit special；
The preservative is methylparaben；
The buffer is sodium citrate and citric acid；
The chelating agent is EDETATE SODIUM；
The essence is essence NJ239954.
10. cosmetics according to claim 9, which is characterized in that be grouped as by the group of following mass fraction：
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| CN111481460A (en) * | 2020-04-14 | 2020-08-04 | 广州市暨新颜生物科技有限公司 | Polypeptide anti-wrinkle anti-aging essence and preparation method thereof |
| CN116183829A (en) * | 2023-02-24 | 2023-05-30 | 广州美域医学检验有限公司 | Cosmetic raw material moisturizing effect testing method and application thereof |
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