CN110200875A - A kind of antiallergic whitening mask and preparation method thereof - Google Patents

A kind of antiallergic whitening mask and preparation method thereof Download PDF

Info

Publication number
CN110200875A
CN110200875A CN201910614930.9A CN201910614930A CN110200875A CN 110200875 A CN110200875 A CN 110200875A CN 201910614930 A CN201910614930 A CN 201910614930A CN 110200875 A CN110200875 A CN 110200875A
Authority
CN
China
Prior art keywords
antiallergic
base fluid
whitening mask
skin
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201910614930.9A
Other languages
Chinese (zh)
Other versions
CN110200875B (en
Inventor
廖云麒
许亮
陈乾华
黄春辉
刘嫦娥
陈君炫
邹佛山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kasi Biological Guangdong Technology Co ltd
Original Assignee
Zhongshan Cassiey Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhongshan Cassiey Biotechnology Co Ltd filed Critical Zhongshan Cassiey Biotechnology Co Ltd
Priority to CN201910614930.9A priority Critical patent/CN110200875B/en
Publication of CN110200875A publication Critical patent/CN110200875A/en
Application granted granted Critical
Publication of CN110200875B publication Critical patent/CN110200875B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9733Lichens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/524Preservatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

Abstract

The invention belongs to cosmetic technical fields, and in particular to a kind of antiallergic whitening mask and preparation method thereof.Antiallergic whitening mask provided by the invention includes facial mask base fluid and non-woven fabrics, and the facial mask base fluid is mainly made of Sodium Hyaluronate, niacinamide, acetyl chitosamine, xanthan gum, dimethyl sulfone, the rough gentian anti-irritant factor, carnosine, nonapeptide -1, arbutin, dipotassium glycyrrhizinate, panthenol, glycerol, natural plant preservative and water.The antiallergic whitening mask that the present invention is prepared can inhibit the catalytic action of tyrosinase from source, melanin is reduced to generate, free radical is removed simultaneously and prevents tyrosine from converting to melanin from anti-oxidant approach, promotes the degradation of cuticula melanin, even skin tone, it lubricates the skin and muscle, bright color, has a significant whitening effect, at the same its also it is mild it is non-stimulated, moistening effect is good, the long advantage of moisture preserving time is a kind of pure natural, safe and harmless antiallergic whitening mask.

Description

A kind of antiallergic whitening mask and preparation method thereof
Technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of antiallergic whitening mask and preparation method thereof.
Background technique
With socio-economic development, life stress is growing day by day, and modern metropolitan cities crowd enters fast pace and diet work and rest not The life of rule, and current air pollution, city haze, ultraviolet light irradiation, and for a long time in face of electrical screens such as portable computers The status of the radiation of curtain, the case where causing modern female to be easy to appear obscure skin and skin darkening.To cope with the dark yellow hair of skin Black situation, domestic and international each skin care item brand side has released many whitening class products, but commercially available whitening product is mostly to add to inhibit The substance of tyrosinase activity is main counter-measure, effect because the absorption of skin care item is bad and the limitations such as additive amount not Have and play considerable effect, and commercially available skin care item are added to various essence, chemical preservative, mineral oil, the work of petroleum surface Property the ingredients such as agent, increase the irritation to skin, cause skin problem that cannot improve.
Facial mask is a kind of external application film of nutrition protection skin of face, easy to use, frequently as used for cosmetic in facial beauty Hold.Contact of the facial mask by barrier skin with air, inhibits sebum secretion and evaporation of perspiration increase skin temperature, skin temperature It after rising, will promote blood circulation, the effective component in facial mask is made to penetrate into epidermis.Blood circulation quickening can make skin red Profit, it is glossy, and skin absorbs more juicy, after nutrition essence and various effective components, skin water shortage and dark can be effectively improved Mute problem.
Patent document CN102940591A discloses a kind of witch hazel moisturizing antiallergic whitening mask, the witch hazel moisturizing antiallergic Whitening mask, including witch hazel extract, yellow chamomile extracting solution, marine algae extract, Angelica Dahurica extract, wheat-germ oil, dimension Raw element E and mineral water.The facial mask being prepared is mentioned with hazel extract, yellow chamomile extracting solution, marine algae extract, the root of Dahurain angelica Taking object is main component, and ingredient is natural, have high moisturizing, deep water supplement, restrain pore, antiallergic of releiving, anti-inflammatory antibacterial, whitening are dispelled The effect of spot.
Patent document CN104784099A discloses a kind of antiallergic face pack powder for skin whitening, the antiallergic face pack powder for skin whitening mainly by Chamomile, ginseng, Rhizoma Atractylodis Macrocephalae, PORIA ALBA, the larva of a silkworm with batrytis, Song Zhu and pearl composition.It is dark that the facemask powder solves skin sensitivity, colour of skin water shortage The problems such as yellow, improves moisture of skin and so that skin is become clear glossy, has effects that the tender skin of moisturizing, channels and collaterals of releiving, antiallergic anti-inflammatory, It to allergic reaction caused by bad cosmetics is used, pacifies, releive, repair function, being a kind of safety naturally effective skin care Product.
Although it is dark yellow to improve skin however, improving the moisture of skin in the presently commercially available antiallergic whitening mask energy short time The problem of, but its lasting moisture preserving time is shorter, and as time went on, moistening effect is lower, changes to the dark yellow problem of skin It is apt to ineffective, is not able to satisfy the requirement of modern.
Summary of the invention
In order to overcome defect existing for antiallergic whitening mask in the prior art, the purpose of the present invention is to provide a kind of antiallergics Whitening mask, the antiallergic whitening mask have significant whitening antiallergic effect, also have that moistening effect is good, moisture preserving time is long, warm With non-stimulated advantage, keeps skin whitening bright, full glossy, can effectively solve defect existing for existing product.
The present invention provides a kind of antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid include with Lower ingredient and its parts by weight:
0.1~0.5 part of Sodium Hyaluronate, 0.2~2.0 part of niacinamide, 0.2~2.0 part of acetyl chitosamine, xanthan gum 0.05 ~0.5 part, 0.2~2.0 part of dimethyl sulfone, 0.2~0.8 part of the rough gentian anti-irritant factor, 0.1~0.8 part of carnosine, nonapeptide -1 0.005 ~0.05 part, 0.05~0.8 part of arbutin, 0.05~0.5 part of dipotassium glycyrrhizinate, 0.05~0.5 part of panthenol, glycerol 1.0~5.0 Part, 0.2~0.8 part of natural plant preservative and 83.2~97.4 parts of water.
Further, the facial mask base fluid includes following component and its parts by weight:
0.3 part of Sodium Hyaluronate, 2.0 parts of niacinamide, 2.0 parts of acetyl chitosamine, 0.2 part of xanthan gum, 1.5 parts of dimethyl sulfone, 0.8 part of the rough gentian anti-irritant factor, 0.5 part of carnosine, 0.01 part of nonapeptide -1,0.8 part of arbutin, 0.3 part of dipotassium glycyrrhizinate, panthenol 0.3 part, 3.0 parts of glycerol, 0.4 part of natural plant preservative and 87.89 parts of water.
Further, the facial mask base fluid further includes 0.2~0.6 part of minerals yeast polypeptides.
Further, the complex compound that the minerals yeast polypeptides are yeast polypeptides complexing calcium, magnesium, potassium are formed.
Further, the arbutin is alpha-arbutin.
Further, the natural plant preservative is that long and thin hot pepper berry extract, pasque flower extract and palpus sunglo mention Take the combination of one or more of object.
Further, the natural plant preservative is white by long and thin hot pepper berry extract 10~20% (weight percent), Korea Head father-in-law's extract 10~20% (weight percent), palpus extractive of usnea 10~20% (weight percent) and excess water are made.
In addition, the present invention also provides the preparation methods of the antiallergic whitening mask, comprising the following steps:
S1 takes the water of half amount, and Sodium Hyaluronate, glycerol, xanthan gum, niacinamide and acetyl chitosamine are added to the water point It dissipates uniformly, is then added in reaction kettle and is heated to 80~85 DEG C, stir evenly;
Dimethyl sulfone is added in remaining water after dispersing and dissolving S2, is added in the reaction kettle of step S1 and stirs evenly, then 45 DEG C are cooled to, the rough gentian anti-irritant factor, carnosine, nonapeptide -1, natural plant preservative is added and stirs evenly;
Dipotassium glycyrrhizinate, arbutin and panthenol are added in the reaction kettle of step S2 and stir evenly by S3, obtain facial mask base fluid, will Non-woven fabrics be put into facial mask base fluid immersion treatment to get.
Further, the step S3 further includes that minerals yeast polypeptides are added.
Long and thin hot pepper (ZANTHOXYLUM PIPERITUM) berry extract of the present invention, pasque flower (PULSATILLA KOREANA) extract, must the extraction process of sunglo (USNEA BARBATA) extract be to add water to cook 2~3 times, merge filter Liquid, be concentrated and dried to get.
Antiallergic whitening mask base fluid provided by the invention is with acetyl chitosamine, niacinamide, dimethyl sulfone, arbutin, carnosine, nine Peptide -1 be main component, from source inhibit tyrosinase catalytic action, reduce melanin generate, while remove free radical from Anti-oxidant approach prevents tyrosine from converting to melanin, promotes the degradation of cuticula melanin, and even skin tone lubricates the skin and muscle, highlights The colour of skin, then the antianaphylaxis components such as the rough gentian anti-irritant factor and dipotassium glycyrrhizinate are added, it is impaired for skin sensitivity or skin barrier Crowd can also accomplish mild not allergy, be finally that skin supplements and latching moisture using Sodium Hyaluronate and xanthan gum, allow face Skin restores profit and plays full state, maintains eubolism, then cooperate the Transdermal absorption facilitation of dimethyl sulfone, allows effectively Ingredient enters skin and maximizes the effect for playing and highlighting whitening.
Antiallergic whitening mask base fluid provided by the invention has good moisturizing whitening effect, concrete principle are as follows: xanthan gum It is a kind of macromolecule glue of molecular weight 1,000,000 or more, a kind of netted protective film can be formed in skin surface, it is hydrophobic Property end and adhering skin, can lock skin water loss, while its light-water end is outwardly, the moisture in air can be absorbed, Good moistening effect can effectively be reached in a short time.And the micromolecular polysaccharide acetyl shell in facial mask base fluid of the present invention Osamine and hyaluronic acid are evenly distributed in inside xanthan gum protective film, and acetyl chitosamine passes through enhancing hyaluronic acid synthetase Activity promotes skin keratin to form the synthesis and secretion of cell and fibroblast to hyaluronic acid, improves in Skin Cell thoroughly Bright matter acid content, while simultaneously bi-directionally working with the hyaluronic acid of external source addition, so as to effectively eliminate skin lines, Keep skin more flexible, meanwhile, the dissacharide units in hyaluronic acid have very strong hydrophily since surface is in negative electrical charge, The water imbibition of xanthan gum protective film can be can be further improved, to improve moisture-keeping function in conjunction with a large amount of hydrone.
However, the water imbibition and moisture of polysaccharide are limited by the ability that aquaporin transports, polysaccharide is protected after saturation The moistening effect of cuticula also can constantly decline.In order to extend the moistening effect of facial mask, the present invention is added to minerals yeast polypeptides, The mineral ions such as calcium, magnesium, potassium in the minerals yeast polypeptides can regulate and control unlatching aquaporin, moisturize and transport The content of cuticula, so as to constantly improve the moisture content of skin, to achieve the effect that long-time moisturizing.
In addition, the acetyl chitosamine in antiallergic whitening mask base fluid provided by the invention can also inhibit the glycosyl of tyrosinase Change, to inhibit the synthesis of tyrosinase maturation reduction melanin.Local pigment calmness can be reduced with niacinamide synergistic effect, Desalinate skin color spot, mitigates UV-induced colour of skin intensification and colour of skin non-uniform phenomenon, it being capable of effective even skin tone.In addition, Acetyl chitosamine can also remove free radical, reduce injury of the free radical to skin, and crease-resistant, anti-aging enhances repairing for skin histology Reactivation power.And antiallergic whitening mask base fluid provided by the invention is not added with chemical preservative, using natural plant preservative, master Ingredient is wanted to mention for long and thin hot pepper (ZANTHOXYLUM PIPERITUM) berry extract, pasque flower (PULSATILLA KOREANA) Object, palpus sunglo (USNEA BARBATA) extract are taken, skin is not stimulated mildly, sensitization rate is low and has efficient antibacterial effect Fruit.
In short, compared with prior art, antiallergic whitening mask provided by the invention has the advantage that
(1) antiallergic whitening mask provided by the invention can inhibit the catalytic action of tyrosinase from source, reduce black Pigment generates, while removing free radical and preventing tyrosine from converting to melanin from anti-oxidant approach, promotes cuticula melanin drop Solution, even skin tone lubricate the skin and muscle, bright color, have significant whitening effect, while its also mild non-stimulated advantage, are A kind of pure natural, safe and harmless antiallergic whitening mask;
(2) antiallergic whitening mask provided by the invention also has the effect that moistening effect is good, and moisture preserving time is grown, and is conducive to increase Whitening, the antianaphylactic effect of strong facial mask.
Specific embodiment
The present invention is further described below by way of specific embodiment, the present invention is not limited only to following embodiment.In this hair In bright range or the contents of the present invention are not being departed from, in spirit and scope, the change that carries out to the present invention is combined or replaced It changes, will be apparent to the person skilled in the art, and be included within the scope of the present invention.Used in the present invention Ingredient is commercially available composition conventional in cosmetic industry.
Embodiment 1, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.1 part of Sodium Hyaluronate, 2.0 parts of niacinamide, 2.0 parts of acetyl chitosamine, 0.5 part of xanthan gum, 0.2 part of dimethyl sulfone, It is 0.2 part of the rough gentian anti-irritant factor, 0.2 part of carnosine, 0.005 part of nonapeptide -1,0.2 part of alpha-arbutin, 0.1 part of dipotassium glycyrrhizinate, general 0.1 part of alcohol, 1.0 parts of glycerol, 0.8 part of long and thin hot pepper berry extract and 92.595 parts of water.
Preparation method:
S1 takes the water of half amount, and Sodium Hyaluronate, glycerol, xanthan gum, niacinamide and acetyl chitosamine are added to the water point It dissipates uniformly, is then added in reaction kettle and is heated to 80~85 DEG C, stir evenly;
Dimethyl sulfone is added in remaining water after dispersing and dissolving S2, is added in the reaction kettle of step S1 and stirs evenly, then 45 DEG C are cooled to, the rough gentian anti-irritant factor, carnosine, nonapeptide -1, natural plant preservative is added and stirs evenly;
Dipotassium glycyrrhizinate, arbutin and panthenol are added in the reaction kettle of step S2 and stir evenly by S3, obtain facial mask base fluid, will Non-woven fabrics be put into facial mask base fluid immersion treatment to get.
Embodiment 2, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.2 part of Sodium Hyaluronate, 0.3 part of niacinamide, 0.4 part of acetyl chitosamine, 0.1 part of xanthan gum, 0.2 part of dimethyl sulfone, It is 0.3 part of the rough gentian anti-irritant factor, 0.2 part of carnosine, 0.05 part of nonapeptide -1,0.2 part of alpha-arbutin, 0.2 part of dipotassium glycyrrhizinate, general 0.2 part of alcohol, 2.0 parts of glycerol, 0.3 part of pasque flower extract, palpus 0.3 part of extractive of usnea, 0.2 part of minerals yeast polypeptides With water 94.85;The complex compound that the minerals yeast polypeptides are yeast polypeptides complexing calcium, magnesium, potassium are formed.
Preparation method is similar to Example 1.
Embodiment 3, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.3 part of Sodium Hyaluronate, 2.0 parts of niacinamide, 2.0 parts of acetyl chitosamine, 0.2 part of xanthan gum, 1.5 parts of dimethyl sulfone, 0.8 part of the rough gentian anti-irritant factor, 0.5 part of carnosine, 0.01 part of nonapeptide -1,0.8 part of arbutin, 0.3 part of dipotassium glycyrrhizinate, panthenol 0.3 part, 3.0 parts of glycerol, 0.4 part of natural plant preservative, 0.4 part of minerals yeast polypeptides and 87.49 parts of water;The minerals The complex compound that yeast polypeptides are yeast polypeptides complexing calcium, magnesium, potassium are formed;The natural plant preservative is by long and thin hot pepper berry extract 15% (weight percent), pasque flower extract 10% (weight percent), palpus 20% (weight percent of extractive of usnea Than) and excess water be made.
Preparation method is similar to Example 1.
Embodiment 4, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.5 part of Sodium Hyaluronate, 0.2 part of niacinamide, 0.2 part of acetyl chitosamine, 0.5 part of xanthan gum, 2.0 parts of dimethyl sulfone, It is 0.8 part of the rough gentian anti-irritant factor, 0.8 part of carnosine, 0.02 part of nonapeptide -1,0.8 part of alpha-arbutin, 0.5 part of dipotassium glycyrrhizinate, general 0.5 part of alcohol, 4.0 parts of glycerol, 0.2 part of natural plant preservative, 0.6 part of minerals yeast polypeptides and 88.38 parts of water;The mineral The complex compound that matter yeast polypeptides are yeast polypeptides complexing calcium, magnesium, potassium are formed;The natural plant preservative is by long and thin hot pepper berry extract 10% (weight percent), pasque flower extract 20% (weight percent), palpus 10% (weight percent of extractive of usnea Than) and excess water be made.
Preparation method is similar to Example 1.
Comparative example 1, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.3 part of Sodium Hyaluronate, 4.0 parts of acetyl chitosamine, 0.2 part of xanthan gum, 1.5 parts of dimethyl sulfone, rough gentian anti-irritant because Sub 0.8 part, 0.5 part of carnosine, 0.01 part of nonapeptide -1,0.8 part of arbutin, 0.3 part of dipotassium glycyrrhizinate, 0.3 part of panthenol, glycerol 3.0 Part, 0.4 part of natural plant preservative, 0.4 part of minerals yeast polypeptides and 87.49 parts of water;The minerals yeast polypeptides are ferment The complex compound that female polypeptide complexing calcium, magnesium, potassium are formed;The natural plant preservative is by 15% (weight percent of long and thin hot pepper berry extract Than), pasque flower extract 10% (weight percent), must extractive of usnea 20% (weight percent) and excess water system At.
Preparation method is similar to Example 1.
Difference with embodiment 3 is: the facial mask base fluid lacks niacinamide, increases the content of acetyl chitosamine.
Comparative example 2, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.5 part of Sodium Hyaluronate, 2.0 parts of niacinamide, 0.2 part of xanthan gum, 1.5 parts of dimethyl sulfone, the rough gentian anti-irritant factor 0.8 Part, 0.5 part of carnosine, 0.01 part of nonapeptide -1,0.8 part of arbutin, 0.3 part of dipotassium glycyrrhizinate, 0.3 part of panthenol, 3.0 parts of glycerol are planted 0.4 part of object natural antiseptic agent, 0.4 part of minerals yeast polypeptides and 89.29 parts of water;The minerals yeast polypeptides are yeast polypeptides The complex compound that complexing calcium, magnesium, potassium are formed;The natural plant preservative is by long and thin hot pepper berry extract 15% (weight percent), court Common Squill Bulb father-in-law extract 10% (weight percent), palpus extractive of usnea 20% (weight percent) and excess water are made.
Preparation method is similar to Example 1.
Difference with embodiment 3 is: the facial mask base fluid lacks acetyl chitosamine, increases the content of Sodium Hyaluronate.
Comparative example 3, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.3 part of Sodium Hyaluronate, 2.0 parts of niacinamide, 2.0 parts of acetyl chitosamine, 0.2 part of xanthan gum, 1.5 parts of dimethyl sulfone, 0.8 part of the rough gentian anti-irritant factor, 0.5 part of carnosine, 0.03 part of nonapeptide -1,0.3 part of dipotassium glycyrrhizinate, 0.3 part of panthenol, glycerol 3.0 Part, 0.4 part of natural plant preservative, 0.4 part of minerals yeast polypeptides and water 88.27;The minerals yeast polypeptides are yeast The complex compound that polypeptide complexing calcium, magnesium, potassium are formed;The natural plant preservative is by 15% (weight percent of long and thin hot pepper berry extract Than), pasque flower extract 10% (weight percent), must extractive of usnea 20% (weight percent) and excess water system At.
Preparation method is similar to Example 1.
Difference with embodiment 3 is: the facial mask base fluid lacks alpha-arbutin, increases the content of nonapeptide -1.
Comparative example 4, a kind of antiallergic whitening mask
The antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, the facial mask base fluid is by following component and its weight Number composition:
0.3 part of Sodium Hyaluronate, 2.0 parts of niacinamide, 2.0 parts of acetyl chitosamine, 0.2 part of Sodium Polyacrylate, dimethyl sulfone 1.5 It is part, 0.8 part of the rough gentian anti-irritant factor, 0.5 part of carnosine, 0.01 part of nonapeptide -1,0.8 part of arbutin, 0.3 part of dipotassium glycyrrhizinate, general 0.3 part of alcohol, 3.0 parts of glycerol, 0.4 part of natural plant preservative, 0.4 part of minerals yeast polypeptides and water 87.49;The mineral The complex compound that matter yeast polypeptides are yeast polypeptides complexing calcium, magnesium, potassium are formed;The natural plant preservative is by long and thin hot pepper berry extract 15% (weight percent), pasque flower extract 10% (weight percent), palpus 20% (weight percent of extractive of usnea Than) and excess water be made.
Preparation method is similar to Example 1.
Difference with embodiment 3 is: xanthan gum is replaced with Sodium Polyacrylate.
Test example one, safety testing
1, test material:
The antiallergic whitening mask that Examples 1 to 4 is prepared.
2, test method:
30 triers are selected, the antiallergic whitening mask that Examples 1 to 4 is prepared carries out patch test, passes through naked eyes Observation is observed dermoreaction, the extent of reaction and grade scoring standard and is shown in Table 1 after 24 hours.
1 dermoreaction of table, the extent of reaction and grade scoring standard
3, test result:
30 people in antiallergic whitening mask being prepared using the embodiment of the present invention 1~4 are negative, and 0 people is in can Reaction is doubted, according to 2015 editions " cosmetics safety technical specification " human skin patch judgment criterias, it was demonstrated that the present invention is implemented The antiallergic whitening mask that example 1~4 is prepared has no adverse reaction to human body.
Test example two, whitening effect test
1, test material:
It is prepared by embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 Obtained antiallergic whitening mask.
2, test method:
It is obscure that 80 skin are chosen in medical and beauty treatment mechanism, and have the spotted trier of facial skin, are randomly divided into 8 Group, every group of 10 people select the face of subject as tested region, and random rotation label uses test equipment by technical staff Initial value data acquisition is carried out, in the tested area (the same area) cleaned by clear water, applies a facial mask every night, is tested Period recipient site cannot be used except other any cosmetics in addition to by sample, the melanin of the using area of test subject Quantity calculates average value, obtains initial value, subsequent testing result is all calculated average value.Continuous use facial mask 2 Month, respectively at using 0 day, 7 days, 14 days, 28 days, 56 days, the dermal melanin and red sanguinin produced using German CK company is surveyed Instrument Mexameter MX 18 is tried, dermal melanin is tested, numerical value is smaller to illustrate that melanin content is fewer, shows skin It is whiter brighter.
3, test result:
Test result is as shown in table 2.
2 dermal melanin of table analyzes test result
As shown in Table 2, the melanin of face can be significantly reduced in antiallergic whitening mask provided by the invention, improves whitening effect Fruit, and the antiallergic whitening mask that antiallergic whitening mask that comparative example 1~4 is prepared is more of the invention to the reducing effect of melanin Difference illustrates that each ingredient interaction of the facial mask base fluid in antiallergic whitening mask provided by the invention plays a part of to reduce melanin.
The moisturizing test of test example three, antiallergic whitening mask
1, subjects:
The mouse for choosing 90 12-13 week old is provided by Nanjing Experimental Animal Center.
2, test material:
It is prepared by embodiment 1, embodiment 2, embodiment 3, embodiment 4, comparative example 1, comparative example 2, comparative example 3 and comparative example 4 Antiallergic whitening mask base fluid, butanediol solution.
3, test method:
90 mouse are shaved off into back coat with shaver, then the skin of exposure size about 2cm × 3cm is randomly divided into 9 Group, every group 10, using butanediol solution as blank control, respectively control group, example 1 group, 2 groups of embodiment, embodiment 3 Group, 4 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, 3 groups of comparative example and 4 groups of comparative example.The moisturizing water constituent of each group is as follows:
Each group facial mask base fluid is applied to the baring skin of mouse, then mouse is placed under dehumidifier environment and exposes, Exposure 6 hours daily, continue 15 days;Then the moisture determination of back of mice baring skin is carried out, after removing depilation with punch Skin histology 0.5g, precision claim skin weight in wet base, place 48h in 80 DEG C of drying boxes, claim skin dry weight.And skin is measured by following equation The skin percentage of moisture: the skin percentage of moisture=(skin weight in wet base-dry weight)/weight in wet base × 100%.
4, test result:
Test result is as shown in table 3.
The test data of 3 mouse skin water content of table
Group The skin percentage of moisture
Control group 35.98%
Example 1 group 76.43%
2 groups of embodiment 78.23%
3 groups of embodiment 81.56%
4 groups of embodiment 77.28%
1 group of comparative example 50.78%
2 groups of comparative example 55.67%
3 groups of comparative example 58.34%
4 groups of comparative example 45.12%
As shown in Table 3, the mouse skin for smearing antiallergic whitening mask base fluid prepared by the embodiment of the present invention 1~4 averagely contains Water percentage is greater than 70%, and the mouse skin for smearing antiallergic whitening mask base fluid prepared by addition comparative example 1~4 is average aqueous Percentage comparisons is low, illustrates that the formula of antiallergic whitening mask base fluid provided by the invention is reasonable, scientific, each component has cooperateed with enhancing The effect of moisturizing.
The moisturizing test of test example four, antiallergic whitening mask base fluid
1, subjects:
Select 48 female volunteers, the age 20-35 years old.
2, test material:
Antiallergic whitening mask base fluid prepared by embodiment 3, comparative example 1, comparative example 2, comparative example 3 and comparative example 4, butanediol Solution.
3, test method:
48 volunteers are randomly divided into 6 groups, using butanediol solution as blank control, every group of 8 people are respectively compareed Group, 3 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, 3 groups of comparative example and 4 groups of comparative example were used continuously 15 days, at the 15th day It is 25 DEG C in room temperature, humidity utilizes CK company, Germany moisture of skin tester Corneometer under conditions of being 50% after for 24 hours CM 825 measures the moisture content of cuticula after 1h and 8h.
4, test result:
Test result is as shown in table 4.
The moisturizing of 4 antiallergic whitening mask base fluid of table is tested
Group Moisture content after smearing 1h Moisture content after smearing 10h
Control group 32.4% 18.3%
3 groups of embodiment 77.8% 71.5%
1 group of comparative example 45.2% 30.6%
2 groups of comparative example 49.4% 32.4%
3 groups of comparative example 50.5% 36.2%
4 groups of comparative example 39.7% 26.6%
As shown in Table 4, after the moisture content using antiallergic whitening mask base fluid of the invention after 1h is 77.8%, 10h Moisture content be 71.5%, divide water content rate of descent be 8.3%, and use comparative example 1~4 prepare antiallergic whitening mask base Liquid moisture content decline after 10h is larger, illustrates that the formula of antiallergic whitening mask base fluid provided by the invention is reasonable, scientific, respectively Component cooperates with the moisture preserving time that can effectively extend antiallergic whitening mask base fluid, enhances moistening effect.

Claims (9)

1. a kind of antiallergic whitening mask, including facial mask base fluid and non-woven fabrics, which is characterized in that the facial mask base fluid include below at Point and its parts by weight:
0.1~0.5 part of Sodium Hyaluronate, 0.2~2.0 part of niacinamide, 0.2~2.0 part of acetyl chitosamine, xanthan gum 0.05~ 0.5 part, 0.2~2.0 part of dimethyl sulfone, 0.2~0.8 part of the rough gentian anti-irritant factor, 0.1~0.8 part of carnosine, nonapeptide -1 0.005~ 0.05 part, 0.05~0.8 part of arbutin, 0.05~0.5 part of dipotassium glycyrrhizinate, 0.05~0.5 part of panthenol, glycerol 1.0~5.0 Part, 0.2~0.8 part of natural plant preservative and 83.2~97.4 parts of water.
2. antiallergic whitening mask as described in claim 1, which is characterized in that the facial mask base fluid includes following component and its again Measure number:
0.3 part of Sodium Hyaluronate, 2.0 parts of niacinamide, 2.0 parts of acetyl chitosamine, 0.2 part of xanthan gum, 1.5 parts of dimethyl sulfone, rough gentian 0.8 part of the anti-irritant factor, 0.5 part of carnosine, 0.01 part of nonapeptide -1,0.8 part of arbutin, 0.3 part of dipotassium glycyrrhizinate, panthenol 0.3 Part, 3.0 parts of glycerol, 0.4 part and 87.89 parts of natural plant preservative.
3. antiallergic whitening mask as claimed in claim 1 or 2, which is characterized in that the facial mask base fluid further includes 0.2~0.6 Part minerals yeast polypeptides.
4. antiallergic whitening mask as claimed in claim 3, which is characterized in that the minerals yeast polypeptides are yeast polypeptides network Close the complex compound that calcium, magnesium, potassium are formed.
5. antiallergic whitening mask as claimed in claim 1 or 2, which is characterized in that the arbutin is alpha-arbutin.
6. antiallergic whitening mask as claimed in claim 1 or 2, which is characterized in that the natural plant preservative is prickly ash berries The combination of one or more of extract, pasque flower extract and palpus extractive of usnea.
7. antiallergic whitening mask as claimed in claim 6, which is characterized in that the natural plant preservative is extracted by prickly ash berries Object 10~20%, pasque flower extract 10~20%, palpus extractive of usnea 10~20% and excess water are made.
8. the preparation method of the antiallergic whitening mask as described in claim 1~7 is any, which comprises the following steps:
S1 takes the water of half amount, and it is equal that Sodium Hyaluronate, glycerol, xanthan gum, niacinamide and acetyl chitosamine are added to the water dispersion It is even, it is then added in reaction kettle and is heated to 80~85 DEG C, stir evenly;
Dimethyl sulfone is added in remaining water after dispersing and dissolving S2, is added in the reaction kettle of step S1 and stirs evenly, then cools down To 45 DEG C, the rough gentian anti-irritant factor, carnosine, nonapeptide -1, natural plant preservative is added and stirs evenly;
Dipotassium glycyrrhizinate, arbutin and panthenol are added in the reaction kettle of step S2 and stir evenly by S3, facial mask base fluid are obtained, by nonwoven Cloth be put into facial mask base fluid immersion treatment to get.
9. the preparation method of antiallergic whitening mask as claimed in claim 8, which is characterized in that the step S3 further includes being added Minerals yeast polypeptides.
CN201910614930.9A 2019-07-09 2019-07-09 Anti-allergy whitening mask and preparation method thereof Active CN110200875B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910614930.9A CN110200875B (en) 2019-07-09 2019-07-09 Anti-allergy whitening mask and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910614930.9A CN110200875B (en) 2019-07-09 2019-07-09 Anti-allergy whitening mask and preparation method thereof

Publications (2)

Publication Number Publication Date
CN110200875A true CN110200875A (en) 2019-09-06
CN110200875B CN110200875B (en) 2022-03-18

Family

ID=67797001

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910614930.9A Active CN110200875B (en) 2019-07-09 2019-07-09 Anti-allergy whitening mask and preparation method thereof

Country Status (1)

Country Link
CN (1) CN110200875B (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110917118A (en) * 2020-01-02 2020-03-27 广州博美芬生物科技有限公司 Mask for inhibiting melanin from refluxing and percutaneous absorption to balance microecology
CN110917061A (en) * 2019-12-26 2020-03-27 华熙生物科技股份有限公司 Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof
CN111388376A (en) * 2020-04-20 2020-07-10 广西诗琳茉莉生物科技集团有限公司 Jasmine herbal anti-allergy soothing mask and preparation method thereof
CN111686032A (en) * 2020-05-29 2020-09-22 广州新诚生物科技有限公司 Essence, preparation method and facial mask
CN112120959A (en) * 2020-10-16 2020-12-25 清远市华宝生物科技有限公司 Acne-removing skin-tendering whitening essence and preparation method thereof
CN112618397A (en) * 2021-01-04 2021-04-09 广东名兰化妆品制造有限公司 Rejuvenation anti-aging repair stock solution and preparation method thereof
CN113143795A (en) * 2021-05-18 2021-07-23 华熙生物科技股份有限公司 Composition containing gamma-aminobutyric acid and application thereof
CN113318013A (en) * 2021-06-16 2021-08-31 深圳莱特尼森生物科技有限公司 Mineral sea mud film for infants
CN113318046A (en) * 2021-06-08 2021-08-31 上海优康化妆品有限公司 Composite plant anti-allergy agent, composite plant anti-allergy composition, preparation method and application thereof
CN114848535A (en) * 2022-06-13 2022-08-05 杭州友丽医疗科技(集团)有限公司 Composition of melanin metabolic enzyme for fading color spots and preparation method
CN115887262A (en) * 2021-12-22 2023-04-04 株式会社Lg生活健康 Cosmetic composition for skin calming comprising palmitoylethanolamide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236631A (en) * 2016-08-17 2016-12-21 肇庆市凯捷科技有限公司 A kind of facial mask liquid of bright color and preparation method thereof
CN109431847A (en) * 2018-12-13 2019-03-08 广州润虹医药科技股份有限公司 A kind of peptide composition and its application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236631A (en) * 2016-08-17 2016-12-21 肇庆市凯捷科技有限公司 A kind of facial mask liquid of bright color and preparation method thereof
CN109431847A (en) * 2018-12-13 2019-03-08 广州润虹医药科技股份有限公司 A kind of peptide composition and its application

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
F. GOROUHI, H. I. MAIBACH: "Role of topical peptides in preventing or treating", 《INTERNATIONAL JOURNAL OF COSMETIC SCIENCE》 *
俞学锋等: "《酵母营养的奥秘》", 30 April 2017, 电子科技大学出版社 *
吴悦,刘学,唐蔚,曹光群: "具有酪氨酸酶抑制作用的酵母多肽的", 《应用化工》 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110917061A (en) * 2019-12-26 2020-03-27 华熙生物科技股份有限公司 Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof
CN110917061B (en) * 2019-12-26 2022-12-30 华熙生物科技股份有限公司 Composition containing ergothioneine extracting solution, brown rice fermentation filtrate and acetyl chitosamine and application thereof
CN110917118A (en) * 2020-01-02 2020-03-27 广州博美芬生物科技有限公司 Mask for inhibiting melanin from refluxing and percutaneous absorption to balance microecology
CN111388376B (en) * 2020-04-20 2022-06-21 广西诗琳茉莉生物科技集团有限公司 Jasmine herbal anti-allergy soothing mask and preparation method thereof
CN111388376A (en) * 2020-04-20 2020-07-10 广西诗琳茉莉生物科技集团有限公司 Jasmine herbal anti-allergy soothing mask and preparation method thereof
CN111686032A (en) * 2020-05-29 2020-09-22 广州新诚生物科技有限公司 Essence, preparation method and facial mask
CN112120959A (en) * 2020-10-16 2020-12-25 清远市华宝生物科技有限公司 Acne-removing skin-tendering whitening essence and preparation method thereof
CN112618397A (en) * 2021-01-04 2021-04-09 广东名兰化妆品制造有限公司 Rejuvenation anti-aging repair stock solution and preparation method thereof
CN113143795A (en) * 2021-05-18 2021-07-23 华熙生物科技股份有限公司 Composition containing gamma-aminobutyric acid and application thereof
CN113318046A (en) * 2021-06-08 2021-08-31 上海优康化妆品有限公司 Composite plant anti-allergy agent, composite plant anti-allergy composition, preparation method and application thereof
CN113318013A (en) * 2021-06-16 2021-08-31 深圳莱特尼森生物科技有限公司 Mineral sea mud film for infants
CN115887262A (en) * 2021-12-22 2023-04-04 株式会社Lg生活健康 Cosmetic composition for skin calming comprising palmitoylethanolamide
CN115887262B (en) * 2021-12-22 2024-02-23 株式会社Lg生活健康 Cosmetic composition for skin calming comprising palmitoylethanolamide
CN114848535A (en) * 2022-06-13 2022-08-05 杭州友丽医疗科技(集团)有限公司 Composition of melanin metabolic enzyme for fading color spots and preparation method

Also Published As

Publication number Publication date
CN110200875B (en) 2022-03-18

Similar Documents

Publication Publication Date Title
CN110200875A (en) A kind of antiallergic whitening mask and preparation method thereof
CN112494406A (en) Whitening and freckle-removing cosmetic and preparation method thereof
CN109044929B (en) Skin care lotion with moisturizing, anti-aging, whitening and freckle removing functions
CN110755351A (en) Whitening, moisturizing and repairing composition and application thereof
CN106176511B (en) A kind of propolis pore cleanser nose film and its preparation method and application
CN107157880A (en) A kind of HERBA DENDROBII moisturizing sleep mask and preparation method thereof
CN113181085A (en) Composition matrix for improving skin problems after makeup and application of composition matrix in cosmetics
CN110974739A (en) Whitening and repairing mask containing alpine edelweiss extract and preparation method thereof
CN111991299A (en) Composition, preparation method and application thereof and cosmetic
CN108714126A (en) Skin care compositions and the preparation method and application thereof with moisturizing and anti-oxidation efficacy
CN112451439A (en) Skin conditioning composition and skin care product containing cannabidiol
KR101915655B1 (en) Cosmetic composition containing Croton Lechleri resin extract
CN110075053A (en) A kind of compound pilose antler moisturizing whitening mask and preparation method thereof suitable for plateau crowd
CN107802576A (en) A kind of natural animal-plant cell replenishers and preparation method thereof
CN108434053A (en) A kind of Essence and preparation method thereof to lubricate the skin and muscle that has effects that compact
CN108685739A (en) It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics
CN107854358A (en) A kind of anti-apolexis composition and the skin care item containing said composition
CN111870541A (en) Herbal whitening compound composition, mask and preparation method thereof
CN111450017A (en) Beautifying essence containing fullerene and preparation method thereof
CN113368003A (en) Composition with overnight muscle repairing effect and preparation method and application thereof
CN105168080B (en) A kind of dual whitening emulsion and preparation method thereof
CN111374919A (en) Plant extract with freckle removing effect and application thereof
KR102376523B1 (en) A cosmetic composition comprising Hibiscus syriacus bark extract
CN108514544A (en) Face's moisturizing liquid and preparation method thereof
CN108392449A (en) A kind of Khotan jade anti-aging lotion and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20220803

Address after: 528400 workshop 1, No. 13, Maonan Road, South China Modern Traditional Chinese medicine city, Nanlang street, Zhongshan City, Guangdong Province

Patentee after: Kasi biological (Guangdong) Technology Co.,Ltd.

Address before: 528400 Zone A and 4, floor 1, plant 2, Science Park, South China Modern Traditional Chinese medicine city, Nanlang Town, Zhongshan City, Guangdong Province

Patentee before: ZHONGSHAN CASSIEY BIOTECHNOLOGY Co.,Ltd.

TR01 Transfer of patent right