CN108685739A - It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics - Google Patents
It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics Download PDFInfo
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- CN108685739A CN108685739A CN201810826819.1A CN201810826819A CN108685739A CN 108685739 A CN108685739 A CN 108685739A CN 201810826819 A CN201810826819 A CN 201810826819A CN 108685739 A CN108685739 A CN 108685739A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The skin matrix of acne is reduced the invention discloses a kind of reparation skin barrier and its is prepared and its cosmetics, skin matrix is rich in multiple efficacies ingredient, several effect extract compoundings, it is mutually reconciled between each ingredient, synergistic effect, make the skin matrix while repairing skin barrier, additionally it is possible to effectively reduce acne.The skin matrix is applied in corresponding cosmetics, skin-care effect of the skin-protection product in terms of maintenance, reduction acne can be promoted.In addition preparation method process arrangement is reasonable, preparation process science, efficient, moderate cost, skin care compositions obtained have both the effect of repairing skin barrier and reducing acne, the composition that can promote structural lipid in human skin keratinocyte's layer, also can effectively inhibit the generation of acne.
Description
Technical field
The present invention relates to cosmetic field, especially a kind of skin matrix and its preparation repaired skin barrier and reduce acne
With its cosmetics.
Background technology
It is increasingly improved with the living standard of the people, people increasingly focus on the maintenance of appearance, and cosmetics are as a kind of skin
Skin maintenance means, used by more and more people, but due to the misleading in market or it is wrongful use skin care item, cause
People, the especially behavior of teenagers make excessive skin care, such as excessively cleaning, excessive face mask film cause skin excessive hydration, excessively stripping
Fall cuticula and cause cuticula excessively thin etc., it is a degree of impaired to cause skin barrier, and skin barrier structure and
Dysfunction is related with a variety of skin problems.
Skin barrier is mainly made of cuticula, structural lipid and water adipose membrane, plays various organizers in protection body
Official is from the invasion of extraneous adverse factor and the stabilization of holding organismic internal environment.And skin barrier is impaired can then cause cuticula
The reduction of water content, through epidermis fluid loss (TEWL) raising, skin sensitivity, grease abnormal secretion etc., it is a variety of to induce
Skin problem, such as drying, erythema, furfur, itch, acne, acne;
Acne is also known as whelk, is a kind of chronic inflammation disease of pilosebaceous follicle, with acne, papule, useless fellow, knot
Section, tumour and scar are characterized, and the skin of healthy brilliant white can bring fine mood and good interpersonal relationships, the generation of acne
The appearance and confidence of people are affected to a certain extent, it is particularly disadvantageous in teen-age healthy growth.The occurrence cause of acne has very
It is a variety of, the wherein impaired generation that can also promote acne of skin barrier.The present invention is for the impaired acne induced of skin barrier, invention
There is the skin care compositions repaired skin barrier and reduce acne simultaneously.
Present reparation class products most of on the market and anti-acne class product are to separate, and majority repairs class product matrix
Excessive oil or nutritional ingredient are moistened and added partially.Such as strong grease of dormant oil, vaseline closure is easy to block hair
Hole, to which the generation of acne be further aggravated, the crowd for being unfavorable for acne skin repairs, and anti-acne class product is again more on the market now
Relatively to stimulate, generally uses retinol, salicylic acid etc. compared with stimulation component, skin barrier is caused further to be damaged, and impaired skin
Skin barrier can lead to the generation of more serious acne again.
Invention content
In view of this, the object of the present invention is to provide skin matrix and its preparations that a kind of reparation skin barrier reduces acne
It, can be while repairing skin barrier, additionally it is possible to effectively reduce acne with its cosmetics.
To achieve the goals above, the present invention provides the following technical solutions:
A kind of skin matrix repaired skin barrier and reduce acne, is made of the raw material of following mass percent:
The present invention also provides a kind of above-mentioned preparation methods repaired skin barrier and reduce the skin matrix of acne, including with
Lower step:
A1) by lecithin and water input water phase pot, heating stirring is warming up to 80~85 DEG C, keeps the temperature 20min, and stirring is equal
It is even, the first water phase is obtained, it is spare;
B1 it) will pierce in A Gan trees benevolence oil, phytosterin ester input oil phase pot, and be heated to 75~80 DEG C, heat preservation
15min obtains the first oil phase, spare;
C1) step a1) made from the first water phase and step b1) made from the first oil phase be pumped into emulsification pot, in vacuum shape
Quickly stirred under state, middling speed emulsifying 2~3min, 7~9min stirred at 80 DEG C, turn to mix slowly be cooled to 45 DEG C successively by
Raw material niacinamide, Gotu Kola P.E, Radix Gentianae extract, peppery mint extract, rice chaff extract, ceramide is added in proportioning
III, β~glucan continues stirring and is cooled to 40 DEG C, detects sense organ physical and chemical index, after the assay was approved, 100 mesh filter screens filter out
Material, obtains skin matrix.
The present invention also provides a kind of application of skin matrix in preparing cosmetics.
The present invention also provides a kind of cosmetics, including above-mentioned skin matrix.
Preferably, the cosmetics are lotion, and the lotion is made of the raw material of following mass percent:
The present invention provides a kind of preparation methods of cosmetics, include the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 80~85 DEG C, keeps the temperature 3~5min, obtains the second oil
Phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 80~85 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the second oil phase and step b2) obtained the second water phase is pumped into emulsification pot, in vacuum shape
Quickly stir 2~3min under state, middling speed emulsifying 1~2min, 7~9min of moderate-speed mixer at 80 DEG C turn to mix slowly cooling
To 45 DEG C;
D2) to step c2) it is added skin matrix and 1 in obtained mixture, the mixture of 2 hexylene glycols and fragrant fresh ketone, slowly
Speed stirring is cooled to 40 DEG C, detects sense organ physical and chemical index, after the assay was approved, 80 mesh filter screen filtering and dischargings are to get cosmetics.
Preferably, 1,2 hexylene glycols, fragrant fresh ketone are mixed and heated to 50~60 DEG C of dissolvings in step d), obtain 1,2 hexylene glycols and
The mixture of fragrant fresh ketone.
The skin matrix of acne is reduced the present invention provides a kind of reparation skin barrier and its is prepared and its cosmetics, shield
Skin matrix is rich in multiple efficacies ingredient, and several effect extracts compound, and are mutually reconciled between each ingredient, act synergistically, make the skin care
Matrix is while repairing skin barrier, additionally it is possible to effectively reduce acne.The skin matrix is applied in corresponding cosmetics,
Skin-care effect of the skin-protection product in terms of maintenance, reduction acne can be promoted.In addition preparation method process arrangement is reasonable, prepares
Cheng Kexue, efficient, moderate cost, skin care compositions obtained have both the effect of repairing skin barrier and reducing acne, can promote
Into the composition of structural lipid in human skin keratinocyte's layer, it also can effectively inhibit the generation of acne.
Specific implementation mode
A kind of skin matrix repaired skin barrier and reduce acne provided by the invention, by the raw material of following mass percent
Composition:
Skin matrix provided by the invention is rich in multiple efficacies ingredient, and several effect extracts compound, between each ingredient mutually
It reconciles, synergistic effect makes the skin matrix while repairing skin barrier, additionally it is possible to effectively reduce acne.By the skin care base
Matter is applied in corresponding cosmetics, can promote skin-care effect of the skin-protection product in terms of maintenance, reduction acne.
The dry fruit tree benevolence oil of Ci A:The dry fruit tree benevolence oil of Ci A contains 80% non-saturated fatty acid, wherein containing abundant Asia oil
Sour (35% or more), remaining has oleic acid (40% or more), saualane, octatecatrienoic acid, palmitic acid, stearic acid etc., can provide
Good alimentary and skin sense, thorn A Gan tree benevolence extract cell culture has facilitation to the generation of glutathione, to human body
There is preferable oxidation resistance, and repair the lipid barrier of skin, there is certain maintenance effect to sensibility skin.
Niacinamide also known as vitamin B3, nicotinic acid, niacinamide are a kind of common cosmetic materials, in vivo with
Ribose, phosphoric acid, adenine form two nucleic acid of nicotinamide adenine (NAD, cozymase) and nicotinamide-adenine dinucleotide phosphate
(NADP, codehydrogenase Ⅱ), plays intermediate hydrogen carrier in many biological oxidation-reductions, receives hydrogen ion and forms reduced form
Nicotinamide adenine dinucleotide (NADH, reduced coenzyme Ⅰ) and reduced nicotinamide adenine dinucleotide phosphate (NADHP,
Reduced Coenzyme II), participate in the metabolism of cell and the synthesis of fat, protein, DNA.
Niacinamide, there are many effect, can inhibit transfer of the melanin to cells of superficial layer, to there is skin whitening to skin
Function, this is also common one of the function of niacinamide, and in addition niacinamide also has significant anti-inflammatory effect and keeps skin energy flat
Weighing apparatus, while cellular energy can be restored, accelerate collagen synthesis, irritation is small, can preferably establish tolerance.
Gotu Kola P.E:Centella is the herb of samphire centella.Centella originates in India, now divides extensively
It is distributed in the world torrid zone, subtropical zone area, south is distributed mainly in China, is the Chinese herbal medicine of China's tradition wound healing, cosmetics
Herb extract is dried using it.Centella herb adds containing asiatic acid, asiaticosid, madecassoside, betulinic acid, motor
This adds asiatic acid, vitamin C, mysoinositol and centellose, volatile oil, fat oil, accumulated snow potash etc..Gotu Kola P.E pair
Staphylococcus aureus, Hemolytic Type streptococcus, various shigella dysenteriaes, typhoid bacillus have inhibiting effect, asiaticosid that can carry
The synthetic quantity of high fibroblast DNA promotes fibroblastic proliferation, and can promote Collagen of Fibroblasts albumen
Synthesis.
Radix Gentianae extract:Rough gentian is Gentianaceae agueweed, and main product is in China Zhejiang, Jiangsu, Heilungkiang, Jilin, the Liao Dynasty
The ground such as peaceful.Rough gentian class extract has bacteriostasis, also has more apparent effect to specific skin inflammation and skin allergy, can inhibit
It is used in the cosmetics of stimulation, and plays anti-inflammatory effect, Radix Gentianae extract has the activation to aromatizing enzyme well, can adjust skin
The estrogen level of part, it is human sebaceous that Radix Gentianae extract secretion cholesteric to Skin Cell, which has facilitation, cholesterine,
In an important soft and moist ingredient, so the addition of Radix Gentianae extract can improve the state of oiliness coarse skin.
Peppery mint extract:Peppery peppermint also known as American mint, Labiatae herbaceos perennial is a kind of by extensively in a word
Hybridization peppermint, originate in Europe, there is introducing and planting with China all over the world now, there is peppery peppermint antibacterial and sterilization to make
With having well to bacillus subtilis, Propiobacterium, staphylococcus saprophyticus, staphylococcus aureus, Malassezia furfur
Inhibit.
Ceramide III:Ceramide III is a kind of lipid matter, it is close with the structure of matter of keratoderma is constituted,
It can penetrate into skin quickly, help the update of skin natural containment, in balance and cuticula that nature aquation can be promoted
Water combine, form a kind of reticular structure, lock moisture.There is good action to skin moisturizing maintenance, is important in cuticula
Skin-active ingredient, can enhance skin barrier, and reconstituted cell forms effective barrier to prevent water loss and reduce external environment
It influences.
Beta glucan:Beta glucan is natural plant glycan, and skin conditioning agent and moisturizer use in cosmetics, together
When the ingredient also have the effects that certain antiallergic is anti-inflammatory, no allergic reaction, moreover it is possible to improve skin moisture-keeping ability.The ingredient can also play
Effect that is anti-oxidant and protecting the skin from uv damage, can reduce wrinkle of skin, improve skin and resist external injury
Ability.
The present invention also provides the preparation methods that above-mentioned reparation skin barrier reduces the skin matrix of acne, including following step
Suddenly:
A1) by lecithin and water input water phase pot, heating stirring is warming up to 80~85 DEG C, keeps the temperature 20min, and stirring is equal
It is even, the first water phase is obtained, it is spare;
B1 it) will pierce in A Gan trees benevolence oil, phytosterin ester input oil phase pot, and be heated to 75~80 DEG C, heat preservation
15min obtains the first oil phase, spare;
C1) step a1) made from the first water phase and step b1) made from the first oil phase be pumped into emulsification pot, in vacuum shape
Quickly stirred under state, middling speed emulsifying 2~3min, 7~9min stirred at 80 DEG C, turn to mix slowly be cooled to 45 DEG C successively by
Raw material niacinamide, Gotu Kola P.E, Radix Gentianae extract, peppery mint extract, rice chaff extract, ceramide is added in proportioning
III, β~glucan continues stirring and is cooled to 40 DEG C, detects sense organ physical and chemical index, after the assay was approved, 100 mesh filter screens filter out
Material, obtains skin matrix.
The preparation method process arrangement of skin matrix provided by the invention is reasonable, preparation process science, can be effective, is made
Skin care compositions have both repair skin barrier and reduce acne the effect of, can promote human skin keratinocyte layer in structural fat
The composition of matter also can effectively inhibit the generation of acne.
The present invention also provides a kind of application of skin matrix in preparing cosmetics.
The present invention also provides a kind of cosmetics, including above-mentioned skin matrix.The cosmetics, which have, to be repaired, reduces acne
Skin-care effect.The cosmetics of the present invention are skin care category cosmetics, can be Essences, can also be lotion, can also be profit
Skin frost can also be other skin-protection products, such as facial mask.In an embodiment of the present invention, cosmetics of the invention are lotion.
Lotion is made of the raw material of following mass percent:
Materials safety used in the present invention has no toxic side effect, and by largely studying, scientific and reasonable compatibility is realized
Synergistic effect between each composition, makes formula have both the effect of repairing skin barrier and reducing acne.It is used in the present invention
Formula system can promote the composition of structural lipid in human skin keratinocyte's layer, also can effectively inhibit the generation of acne.
Inulin lauryl carbamate has excellent emulsification, dispersibility, steady as the emulsification in skin care compositions
Determine agent.
Wheat-germ oil reduces the generation of wrinkle for reinforcing skin connective tissue.
Glycerine to skin have moist moisturizing, protection, frost-cracking-preventing benefit.
Sodium Hyaluronate prevents the generation of wrinkle of skin for moisturizing the skin.
Allantoin is with promotion epithelial cell growth, the flexibility of cutin-softening increase skin, elasticity and gloss
Effect.
Ammonium acryloyl taurate/VP copolymer has excellent emulsification, dispersion, thickening, film forming ability
1,2 hexylene glycols and fragrant fresh ketone play antisepsis in skin care compositions.
The present invention also provides a kind of above-mentioned preparation methods repaired skin barrier and reduce the lotion of acne, including following step
Suddenly:
A2) in wheat-germ oil input oil phase pot, 80~85 DEG C is heated to, 3~5min is kept the temperature, obtain the second oil
Phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 80~85 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the second oil phase and step b2) obtained the second water phase is pumped into emulsification pot, in vacuum shape
Quickly stir 2~3min under state, middling speed emulsifying 1~2min, 7~9min of moderate-speed mixer at 80 DEG C turn to mix slowly cooling
To 45 DEG C;
D2) to step c2) it is added skin matrix and 1 in obtained mixture, the mixture of 2 hexylene glycols and fragrant fresh ketone, slowly
Speed stirring is cooled to 40 DEG C, detects sense organ physical and chemical index, and after the assay was approved, 80 mesh filter screen filtering and dischargings are to get reparation skin screen
Barrier reduces the lotion of acne.
The preparation method process arrangement of lotion provided by the invention is reasonable, preparation process science, efficient, moderate cost, system
The skin care compositions obtained has both the effect of repairing skin barrier and reducing acne, can promote structural in human skin keratinocyte's layer
The composition of lipid also can effectively inhibit the generation of acne.
In the present embodiment, 1,2 hexylene glycols, fragrant fresh ketone are mixed and heated to 50~60 DEG C of dissolvings, obtain 1,2 hexylene glycols and
The mixture of fragrant fresh ketone.
In order to further illustrate the present invention, with reference to embodiment to a kind of reparation skin barrier reduction provided by the invention
The skin matrix of acne and its preparation are described in detail with its cosmetics, but cannot be interpreted as them to protect the present invention
Protect the restriction of range.
Embodiment 1
The skin matrix that skin barrier reduces acne is repaired, is made of the raw material of following mass percent:
1.0% thorn A Gan trees benevolence oil, 0.5% phytosterol esters, 1.0% lecithin, 2.0% niacinamide, 0.50% product
The careless extract of snow, 5.0% Radix Gentianae extract, 1.0% peppery mint extract, 1.0% rice chaff extract, 0.5% ceramide III,
15.0% beta glucan, surplus are water.
The preparation method that skin barrier reduces the skin matrix of acne is repaired, is included the following steps:
A1) by lecithin and water input water phase pot, heating stirring is warming up to 80 DEG C, keeps the temperature 20min, stirs evenly, obtain
It is spare to the first water phase
B1 it) will pierce in A Gan trees benevolence oil, phytosterin ester input oil phase pot, and be heated to 75 DEG C, keep the temperature 15min, obtain
It is spare to the first oil phase;
C1) step a1) made from the first water phase and step b1) made from the first oil phase be pumped into emulsification pot, in vacuum shape
Quickly stirred under state, middling speed emulsifying 2min, 8min stirred at 80 DEG C, turn to mix slowly be cooled to 45 DEG C successively according to the ratio plus
Enter raw material niacinamide, Gotu Kola P.E, Radix Gentianae extract, peppery mint extract, rice chaff extract, ceramide III, β~Portugal
Glycan continues stirring and is cooled to 40 DEG C, detects sense organ physical and chemical index, after the assay was approved, 100 mesh filter screen filtering and dischargings are protected
Skin matrix.
Embodiment 2
The skin matrix that skin barrier reduces acne is repaired, is made of the raw material of following mass percent:
2.0% thorn A Gan trees benevolence oil, 1.0% phytosterol esters, 2.0% lecithin, 5.0% niacinamide, 1.0% accumulated snow
Careless extract, 3.0% Radix Gentianae extract, 2.0% peppery mint extract, 2.0% rice chaff extract, 0.8% ceramide III,
10.0% beta glucan, surplus are water;
A1) by lecithin and water input water phase pot, heating stirring is warming up to 85 DEG C, keeps the temperature 20min, stirs evenly, obtain
It is spare to the first water phase;
B1 it) will pierce in A Gan trees benevolence oil, phytosterin ester input oil phase pot, and be heated to 80 DEG C, keep the temperature 15min, obtain
It is spare to the first oil phase;
C1) step a1) made from the first water phase and step b1) made from the first oil phase be pumped into emulsification pot, in vacuum shape
Quickly stirred under state, middling speed emulsifying 3min, 7min stirred at 80 DEG C, turn to mix slowly be cooled to 45 DEG C successively according to the ratio plus
Enter raw material niacinamide, Gotu Kola P.E, Radix Gentianae extract, peppery mint extract, rice chaff extract, ceramide III, β~Portugal
Glycan continues stirring and is cooled to 40 DEG C, detects sense organ physical and chemical index, after the assay was approved, 100 mesh filter screen filtering and dischargings are protected
Skin matrix.
Embodiment 3
The skin matrix that skin barrier reduces acne is repaired, is made of the raw material of following mass percent:
2.8% thorn A Gan trees benevolence oil, 0.2% phytosterol esters, 2.75% lecithin, 7.8% niacinamide, 3.0% product
The careless extract of snow, 5.0% Radix Gentianae extract, 3.0% peppery mint extract, 5.0% rice chaff extract, 1.0% ceramide III,
5.0% beta glucan, surplus are water;
A1) by lecithin and water input water phase pot, heating stirring is warming up to 85 DEG C, keeps the temperature 20min, stirs evenly, obtain
It is spare to the first water phase;
B1 it) will pierce in A Gan trees benevolence oil, phytosterin ester input oil phase pot, and be heated to 75 DEG C, keep the temperature 15min, obtain
It is spare to the first oil phase;
C1) step a1) made from the first water phase and step b1) made from the first oil phase be pumped into emulsification pot, in vacuum shape
Quickly stirred under state, middling speed emulsifying 2min, 9min stirred at 80 DEG C, turn to mix slowly be cooled to 45 DEG C successively according to the ratio plus
Enter raw material niacinamide, Gotu Kola P.E, Radix Gentianae extract, peppery mint extract, rice chaff extract, ceramide III, β~Portugal
Glycan continues stirring and is cooled to 40 DEG C, detects sense organ physical and chemical index, after the assay was approved, 100 mesh filter screen filtering and dischargings are protected
Skin matrix.
Embodiment 4
The lotion that skin barrier reduces acne is repaired, is made of the raw material of following mass percent:
Inulin lauryl carbamate 3%, wheat-germ oil 5%, glycerine 8%, Sodium Hyaluronate 0.1%, allantoin
0.2%, ammonium acryloyl taurate/VP copolymer 0.3%, skin matrix 30%, 1,2 hexylene glycols made from embodiment 1
0.5%, fragrant fresh ketone 0.5%.
The preparation method that skin barrier reduces the lotion of acne is repaired, is included the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 80 DEG C, 5min is kept the temperature, obtains the second oil phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 85 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the first oil phase and step b2) obtained the second water phase is pumped into emulsification pot, in vacuum shape
Quickly stir 2min under state, middling speed emulsifying 2min, moderate-speed mixer 7min at 80 DEG C turn to mix slowly to be cooled to 45 DEG C;
D2) to step c2) it is added skin matrix and 1 in obtained mixture, the mixture of 2 hexylene glycols and fragrant fresh ketone, slowly
Speed stirring is cooled to 40 DEG C, detects sense organ physical and chemical index, and after the assay was approved, 80 mesh filter screen filtering and dischargings are to get reparation skin screen
Barrier reduces the lotion of acne.
Embodiment 5
The lotion that skin barrier reduces acne is repaired, embodiment 2 is used to make compared with Example 4, in the present embodiment
The skin matrix obtained, other compositions, preparation method are same as Example 4.
Embodiment 6
The lotion that skin barrier reduces acne is repaired, embodiment 3 is used to make compared with Example 4, in the present embodiment
The skin matrix obtained, other compositions, preparation method are same as Example 4.
Embodiment 7
The lotion that skin barrier reduces acne is repaired, is made of the raw material of following mass percent:
Inulin lauryl carbamate 2%, wheat-germ oil 3%, glycerine 5%, Sodium Hyaluronate 0.5%, allantoin
0.3%, ammonium acryloyl taurate/VP copolymer 0.1%, skin matrix 50%, 1,2 hexylene glycols made from embodiment 1
1%, fragrant fresh ketone 0.1%.
The preparation method that skin barrier reduces the lotion of acne is repaired, is included the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 85 DEG C, 3min is kept the temperature, obtains the second oil phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 80 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the second oil phase and step b2) obtained the second water phase is pumped into emulsification pot, in vacuum shape
Quickly stir 3min under state, middling speed emulsifying 1min, moderate-speed mixer 9min at 80 DEG C turn to mix slowly to be cooled to 45 DEG C;
D2) to step c2) it is added skin matrix and 1 in obtained mixture, the mixture of 2 hexylene glycols and fragrant fresh ketone, slowly
Speed stirring is cooled to 40 DEG C, detects sense organ physical and chemical index, and after the assay was approved, 80 mesh filter screen filtering and dischargings are to get reparation skin screen
Barrier reduces the lotion of acne.
Embodiment 8
The lotion that skin barrier reduces acne is repaired, embodiment 2 is used to make compared with Example 7, in the present embodiment
The skin matrix obtained, other compositions, preparation method are same as Example 7.
Embodiment 9
The lotion that skin barrier reduces acne is repaired, embodiment 3 is used to make compared with Example 7, in the present embodiment
The skin matrix obtained, other compositions, preparation method are same as Example 7.
Embodiment 10
The lotion that skin barrier reduces acne is repaired, is made of the raw material of following mass percent:
Inulin lauryl carbamate 5%, wheat-germ oil 10%, glycerine 6%, Sodium Hyaluronate 0.05%, allantois
Element 0.05%, ammonium acryloyl taurate/VP copolymer 0.5%, skin matrix 40%, 1,2 made from embodiment 1 oneself two
Alcohol 0.8%, fragrant fresh ketone 0.8%.
The preparation method that skin barrier reduces the lotion of acne is repaired, is included the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 80 DEG C, 4min is kept the temperature, obtains the second oil phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 85 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the second oil phase and step b2) obtained the second water phase is pumped into emulsification pot, in vacuum shape
Quickly stir 3min under state, middling speed emulsifying 2min, moderate-speed mixer 7min at 80 DEG C turn to mix slowly to be cooled to 45 DEG C;
D2) to step c2) it is added skin matrix and 1 in obtained mixture, the mixture of 2 hexylene glycols and fragrant fresh ketone, slowly
Speed stirring is cooled to 40 DEG C, detects sense organ physical and chemical index, and after the assay was approved, 80 mesh filter screen filtering and dischargings are to get reparation skin screen
Barrier reduces the lotion of acne.
Embodiment 11
The lotion that skin barrier reduces acne is repaired, embodiment 2 is used to make compared with Example 10, in the present embodiment
The skin matrix obtained, other compositions, preparation method are same as in Example 10.
Embodiment 12
The lotion that skin barrier reduces acne is repaired, embodiment 3 is used to make compared with Example 10, in the present embodiment
The skin matrix obtained, other compositions, preparation method are same as in Example 10.
Comparative example 1
The lotion that skin barrier reduces acne is repaired, is made of the raw material of following mass percent:
Inulin lauryl carbamate 3%, wheat-germ oil 5%, glycerine 8%, Sodium Hyaluronate 0.1%, allantoin
0.2%, ammonium acryloyl taurate/VP copolymer 0.3%, 1,2 hexylene glycols 0.5%, fragrant fresh ketone 0.5%, surplus is water.
The preparation method that skin barrier reduces the lotion of acne is repaired, is included the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 80 DEG C, 5min is kept the temperature, obtains the second oil phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 85 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) the second water phase that the first obtained oil phases of step a) and step b) are obtained is pumped into emulsification pot, in vacuum state
Moderate-speed mixer 7min at lower quickly 2min, middling speed emulsifying 2min, 80 DEG C of stirring, turns to mix slowly to be cooled to 45 DEG C;
D2 the mixture of 1,2 hexylene glycols and fragrant fresh ketone) is added in the mixture obtained to step c), mixes slowly and is cooled to
40 DEG C, sense organ physical and chemical index is detected, after the assay was approved, 80 mesh filter screen filtering and dischargings are to get lotion.
Comparative example 2
Lotion is made of the raw material of following mass percent:
Inulin lauryl carbamate 2%, wheat-germ oil 3%, glycerine 5%, Sodium Hyaluronate 0.5%, allantoin
0.3%, ammonium acryloyl taurate/VP copolymer 0.1%, 1,2 hexylene glycols 1%, fragrant fresh ketone 0.1%, surplus is water.
The preparation method that skin barrier reduces the lotion of acne is repaired, is included the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 85 DEG C, 3min is kept the temperature, obtains the second oil phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 80 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the second oil phase and step b2) obtained the second water phase is pumped into emulsification pot, in vacuum shape
Quickly stir 3min under state, middling speed emulsifying 1min, moderate-speed mixer 9min at 80 DEG C turn to mix slowly to be cooled to 45 DEG C;
D2) to step c2) mixture of 1,2 hexylene glycols and fragrant fresh ketone is added in obtained mixture, mix slowly cooling
To 40 DEG C, sense organ physical and chemical index is detected, after the assay was approved, 80 mesh filter screen filtering and dischargings are to get lotion.
Comparative example 3
Lotion is made of the raw material of following mass percent:
Inulin lauryl carbamate 5%, wheat-germ oil 10%, glycerine 6%, Sodium Hyaluronate 0.05%, allantois
Element 0.05%, 0.5%, 1,2 hexylene glycol 0.8% of ammonium acryloyl taurate/VP copolymer, fragrant fresh ketone 0.8%, surplus are
Water.
The preparation method that skin barrier reduces the lotion of acne is repaired, is included the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 80 DEG C, 4min is kept the temperature, obtains the second oil phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, acryloyldimethyl taurine
In ammonium/VP copolymers, water input water phase pot, heating stirring is warming up to 85 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the second oil phase and step b2) obtained the second water phase is pumped into emulsification pot, in vacuum shape
Quickly stir 3min under state, middling speed emulsifying 2min, moderate-speed mixer 7min at 80 DEG C turn to mix slowly to be cooled to 45 DEG C;
D2) to step c2) mixture of 1,2 hexylene glycols and fragrant fresh ketone is added in obtained mixture, mix slowly cooling
To 40 DEG C, sense organ physical and chemical index is detected, after the assay was approved, 80 mesh filter screen filtering and dischargings are to get lotion.
Test crowd is general red, the bellding light of 75 faces and the volunteer with mild or moderate acne, one group of every 5 people are divided into
For 15 groups of test objects;Can be by specification normal use cosmetics, and there is certain ability of language expression, it can cooperating
Personnel complete the appraisal of cosmetics.
Test zone:Full face;
It uses:Daily sooner or later using twice.The 0th week is tested respectively using German CK company's Ts M300 testers and is persistently made
With the percutaneous moisture loss to cheek position after the 4th week, the 8th week, abbreviation TEWL (g/ ㎡ h), i.e. every square metre of area per hour
Scatter and disappear how many grams of water.Skin moisture is lost in TEWL and is very important parameter to the function of assessing skin moisture protective layer, in state
It has been obtained for widely approving on border, can be very good the integrality of reaction skin barrier function.The TEWL of standard is in skin
Skin is dried under lossless state, and in 24 DEG C of environment temperature, ambient humidity measures in the state of being 50%.
Evaluation criterion:Protective layer of skin is more intact, and the content of moisture content will be higher, the numerical value for the TEWL that skin moisture is lost in
Lower, i.e., skin barrier is repaired, and the results are shown in Table 1;The reduction of acne can be divided into:Significantly effectively, effective, invalid, wherein
Acne, which substantially eliminates, can be judged as significantly effectively;Part acne elimination is judged as effectively;Acne does not reduce or reduces unknown
It is aobvious to be judged as in vain, the results are shown in Table 2.
1 TEWL of table repairs result
2 anti-acne experimental result of table
As can be seen from the above data, Examples 1 to 3 skin matrix, 4~12 facial treatment milk of embodiment are when using one section
Between after can reduce percutaneous moisture loss value (TEWL), with comparative example 1-3 comparison, illustrate reparation and reduction acne it is with obvious effects.
Above description enables professional and technical personnel in the field to realize or using this to being stated in the disclosed embodiments
It is bright, it enables those skilled in the art to implement or use the present invention.Various modifications to these embodiments are to this field
It will be apparent for professional technician, the general principles defined herein can be in the spirit for not departing from the present invention
Or in the case of range, realize in other embodiments.Therefore, the present invention is not intended to be limited to these implementations shown in this article
Example, and it is to fit to the widest range consistent with principles disclosed herein and novel features.
Claims (7)
1. a kind of skin matrix repaired skin barrier and reduce acne, which is characterized in that by the raw material group of following mass percent
At:
2. a kind of preparation method as described in claim 1 repaired skin barrier and reduce the skin matrix of acne, feature exist
In including the following steps:
A1) by lecithin and water input water phase pot, heating stirring is warming up to 80~85 DEG C, keeps the temperature 20min, stirs evenly, obtain
It is spare to the first water phase;
B1 it) will pierce in A Gan trees benevolence oil, phytosterin ester input oil phase pot, and be heated to 75~80 DEG C, keep the temperature 15min, obtain
It is spare to the first oil phase;
C1) step a1) made from the first water phase and step b1) made from the first oil phase be pumped into emulsification pot, under vacuum conditions
Quickly stirring, middling speed emulsifying 2~3min stir 7~9min at 80 DEG C, turn to mix slowly to be cooled to 45 DEG C successively according to the ratio
Addition raw material niacinamide, Gotu Kola P.E, Radix Gentianae extract, peppery mint extract, rice chaff extract, ceramide III, β~
Glucan continues stirring and is cooled to 40 DEG C, detects sense organ physical and chemical index, after the assay was approved, 100 mesh filter screen filtering and dischargings obtain
Skin matrix.
3. a kind of application of skin matrix described in claim 1 in preparing cosmetics.
4. a kind of cosmetics, which is characterized in that including skin matrix described in claim 1.
5. cosmetics according to claim 4, which is characterized in that the cosmetics are lotion, and the lotion is by following matter
Measure the raw material composition of percentage:
6. a kind of preparation method of cosmetics as claimed in claim 5, which is characterized in that include the following steps:
A2) wheat-germ oil is put into oil phase pot, heats to 80~85 DEG C, 3~5min is kept the temperature, obtains the second oil phase;
B2) by inulin lauryl carbamate, glycerine, Sodium Hyaluronate, allantoin, ammonium acryloyldime-thyltaurate/VP
In copolymer, water input water phase pot, heating stirring is warming up to 80~85 DEG C, and constant temperature stirs 20min, obtains the second water phase;
C2) step a2) obtained the second oil phase and step b2) obtained the second water phase is pumped into emulsification pot, under vacuum conditions
Quickly stirring 2~3min, middling speed emulsifying 1~2min, 7~9min of moderate-speed mixer at 80 DEG C, turns to mix slowly to be cooled to 45
℃;
D2) to step c2) skin matrix and 1 is added in obtained mixture, the mixture of 2 hexylene glycols and fragrant fresh ketone stirs at a slow speed
It mixes and is cooled to 40 DEG C, detect sense organ physical and chemical index, after the assay was approved, 80 mesh filter screen filtering and dischargings are to get cosmetics.
7. preparation method as claimed in claim 6, which is characterized in that 1,2 hexylene glycols, fragrant fresh ketone are mixed and heated in step d)
50~60 DEG C of dissolvings, obtain the mixture of 1,2 hexylene glycols and fragrant fresh ketone.
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| CN201810826819.1A CN108685739A (en) | 2018-07-25 | 2018-07-25 | It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics |
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| CN201810826819.1A CN108685739A (en) | 2018-07-25 | 2018-07-25 | It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics |
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| CN108785197A (en) * | 2018-06-14 | 2018-11-13 | 上海棠美生物科技有限公司 | A kind of natural cosmetics preservative composition and preparation method thereof |
| CN111568837A (en) * | 2019-06-26 | 2020-08-25 | 李和伟 | Acne-removing dry towel and package |
| CN113041286A (en) * | 2019-12-27 | 2021-06-29 | 上海相宜本草化妆品股份有限公司 | Plant anti-allergic agent for skin |
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| EP2156822A1 (en) * | 2008-08-19 | 2010-02-24 | Imad Znagui | Plant composition for external use on hair and oily preparation comprising such a composition |
| CN105395438A (en) * | 2015-12-31 | 2016-03-16 | 青岛美博生物技术有限公司 | Acne-removal skin-care lotion and preparation method thereof |
| CN106177100A (en) * | 2016-08-29 | 2016-12-07 | 欧标（广州）化妆品有限公司 | A kind of compositions with anti-acne effect and application thereof |
| CN107823019A (en) * | 2017-12-19 | 2018-03-23 | 广东德新科技孵化器有限公司 | A kind of moisturizing emulsion of smoothing wrinkle and desalination scar and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2156822A1 (en) * | 2008-08-19 | 2010-02-24 | Imad Znagui | Plant composition for external use on hair and oily preparation comprising such a composition |
| CN105395438A (en) * | 2015-12-31 | 2016-03-16 | 青岛美博生物技术有限公司 | Acne-removal skin-care lotion and preparation method thereof |
| CN106177100A (en) * | 2016-08-29 | 2016-12-07 | 欧标（广州）化妆品有限公司 | A kind of compositions with anti-acne effect and application thereof |
| CN107823019A (en) * | 2017-12-19 | 2018-03-23 | 广东德新科技孵化器有限公司 | A kind of moisturizing emulsion of smoothing wrinkle and desalination scar and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108785197A (en) * | 2018-06-14 | 2018-11-13 | 上海棠美生物科技有限公司 | A kind of natural cosmetics preservative composition and preparation method thereof |
| CN111568837A (en) * | 2019-06-26 | 2020-08-25 | 李和伟 | Acne-removing dry towel and package |
| CN111568837B (en) * | 2019-06-26 | 2022-05-24 | 李和伟 | Acne-removing dry towel and package |
| CN113041286A (en) * | 2019-12-27 | 2021-06-29 | 上海相宜本草化妆品股份有限公司 | Plant anti-allergic agent for skin |
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Application publication date: 20181023 |