CN105395438A - Acne-removal skin-care lotion and preparation method thereof - Google Patents

Abstract

The invention provides an acne-removal skin-care lotion and a preparation method thereof. A skin-care product composition is prepared from 0.5-1.8% of nicotinamide, 2-12% of propylene glycol, 0.01-0.2% of licorice root extract, 0.001-0.005% of polyquaternium-73, 2-5% of fitosterole, 0.1-0.8% of hydroxyethyl cellulose, 0.1-1.5% of allantoin, 0.08-0.11% of preservative and the balance water. The skin-care lotion is rich in natural herbal plant ingredient, and an acne-removal natural extract composition with oil control and acne removal effects and acne-removal cream prepared from the composition are provided. In addition, the invention further provides the preparation method of the acne-removal skin-care lotion, and the process is simple.

Description

A kind of anti-acne skin care liquid and preparation method thereof

Technical field

The invention belongs to cosmetic field, particularly a kind of anti-acne skin care liquid.

Background technology

Acne also claims comedo, is that one betides pilosebaceous chronic dermatosis, is mainly in Head And Face, the position that the sebaceous gland such as cervical region, shirtfront back are abundant.The main clinical manifestation of acne is blackhead, Whiteheads, inflamed papules, pustule, tuberosity, cyst, the even cicatrix sample infringement of easy formation pigmentation, corse sweat pore, not only affect attractive in appearance, severe patient can cause disfeaturing, and causes great mental pressure and psychic pain to youngster.Early discovery, the early treatment of primary disease are very important, and the infringement of skin can be avoided or reduce to the diagnosis and treatment of timely specification.Adolescence androgen increases, and smegma increases, and makes the different hyperkeratosis of hair follicle, sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls hair follicle infundibulum, is combined with sebum, produces mixture.If these mixture freely can not discharge skin surface, and deposit form fat bolt in hair follicle.When these dyskeratosis cell aggregationes, when lower hopper expands, just form ripe acne.Sebum is by the bacterial decomposition existed in hair follicle, and produce fatty acid, the latter's hair follicle stimulating causes inflammation, and causes follicular wall lesion ruptures, and hair follicle content enters corium, thus, cause the inflammatory reaction of perifollicolar varying degree.

At present, a lot of product for resolving poxes uses hormone, antibiotic, retinoic acid, the compositions such as fruit acid, and zest is large, and easily cause skin to the drug resistance of Propiobacterium, safety is constantly under suspicion.To sum up, this area is badly in need of a kind ofly can making up prior art defect and the good skin care formulation of technique effect.

Summary of the invention

The object of this invention is to provide one and contain natural herbs composition, there is the anti-acne skin care liquid of control oil and anti-acne effect, be in fact achieved through the following technical solutions: it comprises following raw material and each raw materials quality mark is: nicotiamide 0.5%-1.8%; Propylene glycol 2-12%; Licorice root extract 0.01%-0.2%; Polyquaternary ammonium salt-730.001%-0.005%; Phytosterol 2%-5%; Hydroxyethyl-cellulose 0.1%-0.8%; Allantoin 0.1%-1.5%; Antiseptic 0.08%-0.11%, surplus is water.

Preferably, each raw materials quality mark of described anti-acne skin care liquid is: nicotiamide 0.5%-1.8%; Propylene glycol 2%-12%; Licorice root extract 0.01%-0.2%; Methyl hydroxybenzoate 0.1%; Methylisothiazolinone 0.008%; Polyquaternary ammonium salt-730.001%-0.005%; Phytosterol 2%-5%; Hydroxyethyl-cellulose 0.1%-0.8%; Allantoin 0.1%-1.5%; Surplus is water.

Preferably, each raw materials quality mark is: nicotiamide 1%; Methylisothiazolinone 0.008%; Propylene glycol 10%; Licorice root extract 0.05%; Methyl hydroxybenzoate 0.1%; Polyquaternary ammonium salt-730.002%; Phytosterol 3%; Hydroxyethyl-cellulose 0.5%; Allantoin 0.2%; Surplus is water.

Preferably, described water is deionized water.

Preferably, described phytosterol is plant sterol or plant sterol ester.

The present invention also proposes a kind of preparation method of anti-acne skin care liquid, comprises the steps:

A: add water in emulsion tank, be heated to 80-85 DEG C, adds nicotiamide, Methylisothiazolinone makes it to be uniformly dissolved under stirring;

B: then propylene glycol, licorice root extract, methyl hydroxybenzoate, polyquaternary ammonium salt-73 are added to while stirring in the emulsion tank of steps A, then cool to 35 DEG C;

C: then add successively in the emulsion tank of step B by phytosterol, hydroxyethyl-cellulose, allantoin, carries out after stirring filtering out material, leaves standstill 12h;

D: detect qualified after, fill;

E: packaging;

Wherein, each raw material and content as follows: nicotiamide 0.5%-1.8%; Propylene glycol 2%-12%; Licorice root extract 0.01%-0.2%; Methyl hydroxybenzoate 0.1%; Methylisothiazolinone 0.008%; Polyquaternary ammonium salt-730.001%-0.005%; Phytosterol 2%-5%; Hydroxyethyl-cellulose 0.1%-0.8%; Allantoin 0.1-1.5%; Surplus is water.

Preferably, the preparation method of described skin care liquid comprises the steps:

A: add water in emulsion tank, adds nicotiamide, Methylisothiazolinone, is heated to 80-85 DEG C under stirring, make it to be uniformly dissolved;

B: then propylene glycol, licorice root extract, methyl hydroxybenzoate, polyquaternary ammonium salt-73 are added to while stirring in the emulsion tank of steps A, then cool to 35 DEG C;

C: then add successively in the emulsion tank of step B by phytosterol, hydroxyethyl-cellulose, allantoin, carries out after stirring filtering out material, leaves standstill 12h.

D: after the assay was approved, fill

E: packaging;

Wherein, each raw material and content as follows: nicotiamide 1%; Propylene glycol 10%; Licorice root extract 0.05%; Methyl hydroxybenzoate 0.1%; Methylisothiazolinone 0.008%; Polyquaternary ammonium salt-730.002%; Phytosterol 3%; Hydroxyethyl-cellulose 0.5%; Allantoin 0.2%; Surplus is water.

Licorice root extract in the present invention, containing multiple active ingredient, the pharmacy values such as its antiinflammatory, antiallergic, antiulcer, antioxidation, antiviral are studied in large quantities and are confirmed.The present invention's licorice root extract used is commercially available or general extraction methods extracts, and the present invention is not described further.

Allantoin can improve skin keratin metabolism, dredging hair follicle, simultaneously can accelerating wound healing, reduces irritated and moisturizing skin.

Plant sterol is conventional does Skin Cell promoter, antiinflammatory, Wound-healing agent.

Nicotiamide, has another name called vitamin B3, vitamin PP, niacin amide, is the one of vitamin B group.In the treatment of comedo and acne, mainly use antibiotic traditionally.Although the comedo of this Therapeutic Method to general or local has certain curative effect, life-time service can make bacterial resistance occurred.A result of study display of the state University Medical College in USA New York, can utilize the inflammatory properties of nicotiamide but not sterilization idiocratic reaches the object for the treatment of comedo.Control experiment is carried out with clindamycin (Clindamycin: a kind of antibiotic) ointment containing 1% with the nicotiamide ointment containing 4%, result is after 8 weeks, and the effect of nicotiamide in the minimizing etc. of the improvement to adolescence symptom, inflammation focus number exceedes clindamycin 20%.

Anti-acne skin care liquid prepared by the present invention contains natural herbs composition, effectively can dispel the dry aging cutin of skin surface, control skin oil and fat secretion excessive, dissolve pus in small pox and make its healing of closing up fast, having the effect of the skin that compacts simultaneously.In addition, skin care liquid preparation method of the present invention is simple, easy to operate, and the skin care liquid character of preparation is stablized, easy to use.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention will be further described.

The anti-acne skin care liquid of embodiment one, the present embodiment comprises following raw material and content: each raw materials quality mark is: nicotiamide 1%; Methylisothiazolinone 0.008%; Propylene glycol 10%; Licorice root extract 0.05%; Methyl hydroxybenzoate 0.1%; Polyquaternary ammonium salt-730.002%; Phytosterol 3%; Hydroxyethyl-cellulose 0.5%; Allantoin 0.2%; Water: 84.89%, the water in the present embodiment is deionized water.

The preparation method of this skin care liquid comprises the steps: A: in emulsion tank, add water, adds nicotiamide, Methylisothiazolinone, be heated to 80-85 DEG C under stirring, makes it to be uniformly dissolved;

B: then propylene glycol, licorice root extract, methyl hydroxybenzoate, polyquaternary ammonium salt-73 are added to while stirring in the emulsion tank of steps A, then cool to 35 DEG C;

C: then add successively in the emulsion tank of step B by phytosterol, hydroxyethyl-cellulose, allantoin, carries out after stirring filtering out material, leaves standstill 12h.

D: after the assay was approved, fill

E: packaging, the product after packaging can be sold.

Embodiment two,

The anti-acne skin care liquid of the present embodiment comprises following component and content: 0.5% nicotiamide; 0.008% Methylisothiazolinone; 3% propylene glycol; 0.02% licorice root extract; 0.1% methyl hydroxybenzoate; 0.002% polyquaternary ammonium salt-73; 3.5% phytosterol; 0.15% hydroxyethyl-cellulose; 1% allantoin; 91.72% water.

Its preparation technology is identical with the preparation technology of embodiment one, does not repeat them here.

Embodiment three,

The anti-acne skin care liquid of the present embodiment comprises following component and content: 1.8% nicotiamide; 0.008% Methylisothiazolinone; 12% propylene glycol; 0.2% licorice root extract; 0.1% methyl hydroxybenzoate; 0.004% polyquaternary ammonium salt-73; 4.5% phytosterol; 0.75% hydroxyethyl-cellulose; 0.03% allantoin; Surplus is water.

Its preparation technology is identical with the preparation technology of embodiment one, does not repeat them here.

Embodiment four, utilizes the skin care liquid prepared by embodiment 1 to carry out compliance test result.

Using method: after clean skin, gets the skin care liquid that appropriate the present invention obtains and wipes in long pox position with spot printing method, and massage the several seconds gently.Every day 2-3 time.

Clinical trial:

This products application in light, in, the lanqin oral solutions of severe acne

1, with selecting data:

This group 168 example: routine female 90 example of man 78

Age 16-48 year

The course of disease 1 month-4 years

2, Therapeutic Method:

Get this product number to drip, in this checking each user get 2 (general 0.05ml) be applied to cleaning after acne hair follicle place, every day, spot printing 2-3 time, 10 days was a course for the treatment of, and setting 6-8 course for the treatment of is desired therapeutical effect scope.

3, therapeutic outcome

3.1 indications and criterion of therapeutical effect

Mild acne: papular type

Moderate acne: swollen bleb type

Severe acne: cyst, nodular type

Criterion of therapeutical effect:

Cure: deflorescence more than 95%, occurs without new erythra; Or inactive product more than 30 days, then inflamed papules≤3 of tissue regeneration promoting;

Effective: deflorescence more than 60%, occur without new erythra; Or inactive product is after 30 days, then inflamed papules≤3 of tissue regeneration promoting;

Invalid: deflorescence <50%, or new erythra constantly occurs, regenerates more acne after drug withdrawal.

3.2 result

In 168 examples, recovery from illness 156 example, accounts for 92%; Effective 9 examples, account for 0.5%; Invalid 3 examples, account for 0.17%; Total effective rate is 98.2%.

It should be noted that, refractory patient is skin nodules without regeneration patients with acne: because hair follicle is repeatedly by inflammatory infiltration, cause pilosebaceous unit structural deterioration to form the red tuberosity exceeding skin surface, cause hair follicle connective tissue proliferation, this type of patient generally must take effect really a 10-20 course for the treatment of side

Acne lesions is mainly distributed in face, part involves neck and upper breast, back, it causes main cause is that hair follicle sebum glandular secretion oils and fats is too much, keratinization thing and sebum are filled in pilosebaceous orifices, follicle keratinocytes is caused to block, and oils and fats and the attached work of antibacterial in hair follicle, the final reaction causing red swelling of the skin inflammation.

Therefore, solving acne lesions to clear up follicular keratosis thing, should dispel skin aging cutin, dissolves pus in hair follicle, controls and recovers hair follicle fat secretion balance.Therefore the application of this product, fundamentally can solve the generation of acne lesions, and acne large area can better be prevented to regenerate.

In process on probation, all on probation per capita without untoward reaction such as appearance allergy.

In addition, embodiment two and embodiment three are applied to equally other similar test populations of symptom, result with to utilize embodiment one to obtain product effect consistent, therefore repeats no more.

Above embodiment only in order to technical scheme of the present invention to be described, but not is limited; Although with reference to previous embodiment to invention has been detailed description, for the person of ordinary skill of the art, still can modify to the technical scheme described in previous embodiment, or equivalent replacement is carried out to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.

Claims (7)

1. an anti-acne skin care liquid, is characterized in that, it comprises following raw material and each raw materials quality mark is:

Material content

Nicotiamide 0.5%-1.8%;

Propylene glycol 2%-12%;

Licorice root extract 0.01%-0.2%;

Polyquaternary ammonium salt-730.001%-0.005%;

Phytosterol 2%-5%;

Hydroxyethyl-cellulose 0.1%-0.8%;

Allantoin 0.1%-1.5%;

Antiseptic 0.08%-0.11%

Water surplus.

2. a kind of anti-acne skin care liquid according to claim 1, is characterized in that, each raw materials quality mark is:

Material content

Nicotiamide 0.5%-1.8%;

Propylene glycol 2%-12%;

Licorice root extract 0.01%-0.2%;

Methyl hydroxybenzoate 0.1%;

Methylisothiazolinone 0.008%;

Polyquaternary ammonium salt-730.001%-0.005%;

Phytosterol 25-5%;

Hydroxyethyl-cellulose 0.1%-0.8%;

Allantoin 0.1%-1.5%;

Water surplus.

3. a kind of anti-acne skin care liquid according to claim 2, is characterized in that, each raw materials quality mark is:

Material content

Nicotiamide 1%;

Methylisothiazolinone 0.008%;

Propylene glycol 10%;

Licorice root extract 0.05%;

Methyl hydroxybenzoate 0.1%;

Polyquaternary ammonium salt-730.002%;

Phytosterol 3%;

Hydroxyethyl-cellulose 0.5%;

Allantoin 0.2%;

Water surplus.

4. anti-acne skin care liquid according to claim 3, is characterized in that, described water is deionized water.

5. anti-acne skin care liquid according to claim 4, is characterized in that, described phytosterol is plant sterol or plant sterol ester.

6. a preparation method for anti-acne skin care liquid, is characterized in that, comprises the steps:

A: add water in emulsion tank, adds nicotiamide, Methylisothiazolinone, is heated to 80-85 DEG C under stirring, make it to be uniformly dissolved;

B: then propylene glycol, licorice root extract, methyl hydroxybenzoate, polyquaternary ammonium salt-73 are added to while stirring in the emulsion tank of steps A, then cool to 35 DEG C;

C: then add successively in the emulsion tank of step B by phytosterol, hydroxyethyl-cellulose, allantoin, carries out after stirring filtering out material, leaves standstill 12h;

D: detect qualified after, fill;

E: packaging;

Wherein, each component and content as follows: nicotiamide 0.5%-1.8%; Propylene glycol 2%-12%; Licorice root extract 0.01%-0.2%; Methyl hydroxybenzoate 0.1%; Methylisothiazolinone 0.008%; Polyquaternary ammonium salt-730.001%-0.005%; Phytosterol 2%-5%; Hydroxyethyl-cellulose 0.1%-0.8%; Allantoin 0.1-1.5%; Surplus is water.

7. anti-acne skin care liquid according to claim 6, is characterized in that, comprise the steps:

A: add water in emulsion tank, adds nicotiamide, Methylisothiazolinone, is heated to 80-85 DEG C under stirring, make it to be uniformly dissolved;

B: then propylene glycol, licorice root extract, methyl hydroxybenzoate, polyquaternary ammonium salt-73 are added to while stirring in the emulsion tank of steps A, then cool to 35 DEG C;

C: then add successively in the emulsion tank of step B by phytosterol, hydroxyethyl-cellulose, allantoin, carries out after stirring filtering out material, leaves standstill 12h;

D: detect qualified after, fill;

E: packaging;

Wherein, each component and content as follows: nicotiamide 1%; Propylene glycol 10%; Licorice root extract 0.05%; Methyl hydroxybenzoate 0.1%; Methylisothiazolinone 0.008%; Polyquaternary ammonium salt-730.002%; Phytosterol 3%; Hydroxyethyl-cellulose 0.5%; Allantoin 0.2%; Surplus is water.